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[PMID]: 29287889 [Au] Autor: Cesca F; Bettella E; Polli R; Cama E; Scimemi P; Santarelli R; Murgia A [Ad] Endereço: Laboratory of Molecular Genetics of Neurodevelopment, Department of Women's and Children's Health, University of Padova, Italy. [Ti] Título: A novel mutation of the EYA4 gene associated with post-lingual hearing loss in a proband is co-segregating with a novel PAX3 mutation in two congenitally deaf family members. [So] Source: Int J Pediatr Otorhinolaryngol;104:88-93, 2018 Jan. [Is] ISSN: 1872-8464 [Cp] País de publicação: Ireland [La] Idioma: eng [Ab] Resumo: OBJECTIVES: This work was aimed at establishing the molecular etiology of hearing loss in a 9-year old girl with post-lingual non-syndromic mild sensorineural hearing loss with a complex family history of clinically heterogeneous deafness. METHODS: The proband's DNA was subjected to NGS analysis of a 59-targeted gene panel, with the use of the Ion Torrent PGM platform. Conventional Sanger sequencing was used for segregation analysis in all the affected relatives. The proband and all the other hearing impaired members of the family underwent a thorough clinical and audiological evaluation. RESULTS: A new likely pathogenic mutation in the EYA4 gene (c.1154C > T; p.Ser385Leu) was identified in the proband and in her 42-year-old father with post-lingual non-syndromic profound sensorineural hearing loss. The EYA4 mutation was also found in the proband's grandfather and uncle, both showing clinical features of Waardenburg syndrome type 1. A novel pathogenic splice-site mutation (c.321+1G > A) of the PAX3 gene was found to co-segregate with the EYA4 mutation in these two subjects. CONCLUSION: The identified novel EYA4 mutation can be considered responsible of the hearing loss observed in the proband and her father, while a dual molecular diagnosis was reached in the relatives co-segregating the EYA4 and the PAX3 mutations. In these two subjects the DFNA10 phenotype was masked by Waardenburg syndrome. The use of NGS targeted gene-panel, in combination with an extensive clinical and audiological examination led us to identify the genetic cause of the hearing loss in members of a family in which different forms of autosomal dominant deafness segregate. These results provide precise and especially important prognostic and follow-up information for the future audiologic management in the youngest affected member. [Mh] Termos MeSH primário: Surdez/genética Perda Auditiva Neurossensorial/genética Fator de Transcrição PAX3/genética Transativadores/genética Síndrome de Waardenburg/genética [Mh] Termos MeSH secundário: Adulto Audiometria Criança Família Feminino Sequenciamento de Nucleotídeos em Larga Escala Seres Humanos Masculino Mutação Linhagem Fenótipo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (EYA4 protein, human); 0 (PAX3 Transcription Factor); 0 (PAX3 protein, human); 0 (Trans-Activators) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171231 [St] Status: MEDLINE

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[PMID]: 29400027 [Au] Autor: Montava M; Curto CL; Mancini J; Collin M; Lavieille JP [Ti] Título: [Comparison of stapes protheses: A prospective analysis of audiometric results obtained after stapedotomy by implantation of a teflon piston and a Soft-CliP® piston]. [So] Source: Rev Laryngol Otol Rhinol (Bord);136(3):97-102, 2015. [Is] ISSN: 0035-1334 [Cp] País de publicação: France [La] Idioma: fre [Ab] Resumo: A wide variety of pistons are available for stapes surgery in otosclerosis. The objective of this work was to analyze the short-term and medium-term results of Soft-CliP® piston in prima­ry stapes surgery and to compare it with a conventional prosthesis. The study was prospective, monocentric, rando­mi­zed, based on efficiency of Soft-CliP® prosthesis (11 patients) versus Causse® Teflon prosthesis (9 patients) in otosclerosis surgery. Epidemiological data, treatment modalities, pure-tone audiometric results and outcome of patients were studied. Mean follow-up was 10 months. Soft-CliP® placement was statisti­cally longer. The mean postoperative air-bone gap was within 10 dB in 73% and 67% of cases at 2 months and in 82% and 89% of cases at medium-term in Soft-CliP® and Teflon groups respectively. A statistically significant decrease in mean air-bone gap and for all frequencies was observed at 2 months and at medium term, with no difference between the 2 groups. The main result was the demonstration of the reliability and safety of Soft-CliP® prosthesis. With a new design, Soft-CliP® place­ment was easy. The biomechanics of ossicular chain should be better preserved, and the risk of incus erosion and necrosis decreased. A study on a larger population in the long-term would validate these results. [Mh] Termos MeSH primário: Audiometria Prótese Ossicular Otosclerose/cirurgia Cirurgia do Estribo [Mh] Termos MeSH secundário: Adulto Idoso Feminino Seres Humanos Masculino Meia-Idade Estudos Prospectivos Desenho de Prótese Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180206 [St] Status: MEDLINE

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[PMID]: 27770624 [Au] Autor: Rocchi F; Dylla ME; Bohlen PA; Ramachandran R [Ad] Endereço: Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN 37212, USA. [Ti] Título: Spatial and temporal disparity in signals and maskers affects signal detection in non-human primates. [So] Source: Hear Res;344:1-12, 2017 Feb. [Is] ISSN: 1878-5891 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Detection thresholds for auditory stimuli (signals) increase in the presence of maskers. Natural environments contain maskers/distractors that can have a wide range of spatiotemporal properties relative to the signal. While these parameters have been well explored psychophysically in humans, they have not been well explored in animal models, and their neuronal underpinnings are not well understood. As a precursor to the neuronal measurements, we report the effects of systematically varying the spatial and temporal relationship between signals and noise in macaque monkeys (Macaca mulatta and Macaca radiata). Macaques detected tones masked by noise in a Go/No-Go task in which the spatiotemporal relationships between the tone and noise were systematically varied. Masked thresholds were higher when the masker was continuous or gated on and off simultaneously with the signal, and lower when the continuous masker was turned off during the signal. A burst of noise caused higher masked thresholds if it completely temporally overlapped with the signal, whereas partial overlap resulted in lower thresholds. Noise durations needed to be at least 100 ms before significant masking could be observed. Thresholds for short duration tones were significantly higher when the onsets of signal and masker coincided compared to when the signal was presented during the steady state portion of the noise (overshoot). When signal and masker were separated in space, masked signal detection thresholds decreased relative to when the masker and signal were co-located (spatial release from masking). Masking release was larger for azimuthal separations than for elevation separations. These results in macaques are similar to those observed in humans, suggesting that the specific spatiotemporal relationship between signal and masker determine threshold in natural environments for macaques in a manner similar to humans. These results form the basis for future investigations of neuronal correlates and mechanisms of masking. [Mh] Termos MeSH primário: Comportamento Animal Sinais (Psicologia) Ruído/efeitos adversos Mascaramento Perceptivo Nível de Percepção Sonora Detecção de Sinal Psicológico Localização de Som [Mh] Termos MeSH secundário: Estimulação Acústica Animais Audiometria Vias Auditivas/fisiologia Limiar Auditivo Macaca mulatta Macaca radiata Masculino Modelos Animais Periodicidade Psicoacústica Fatores de Tempo [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180226 [Lr] Data última revisão: 180226 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161023 [St] Status: MEDLINE

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[PMID]: 29328642 [Au] Autor: Mihailovic D; Duric N; Kovacevic I; Mihailovic D [Ti] Título: The effects of industrial noise of higher spectrum on the workers' auditory perception abilities. [So] Source: Vojnosanit Pregl;73(11):1030-7, 2016 Aug. [Is] ISSN: 0042-8450 [Cp] País de publicação: Serbia [La] Idioma: eng [Ab] Resumo: Background/Aim: Results of previous studies gave support to the idea that machines in power plants produce noise of different levels of loudness and frequency, and that it could cause deterioration of the hearing ability of workers. As a matter of fact, noiseinduced hearing loss is the most widespread occupational disease nowadays. As noise is a complex acoustic phenomenon, more factors have to be considered when studying it, such as frequency, intensity and the period of exposure. The aim of this study was to find if there are differences in the absolute threshold of hearing between workers in the factory production lines that are constantly exposed to the industrial noise of higher spectrum and those exposed to the noise of standard spectrum at different frequencies of sound. Methods: In the research plan, there were 308 workers employed in the production line of the Factory "Knjaz Milos", Arandelovac. A total of 205 of them were working in the conditions of higher spectrum noise (4,000 Hz ­ 8,000 Hz) and 103 workers were exposed to standard noise spectrum (31.5 Hz ­ 2,000.0 Hz). The objective measures of noise (frequency and amplitude) were acquired by phonometer, and measures of absolute threshold of hearing for both ears were obtained by audiometer by exposure to nine sound frequency levels. Data were statistically analyzed by establishing the significance of differences between absolute thresholds of hearing for both groups and for all nine frequency levels. Results: It was found that the absolute threshold of hearing is significantly higher for the group exposed to highfrequency noise at the 4,000 Hz and 8,000 Hz levels of frequency. Conclusion: Reduction of hearing sensitivity is evident for those exposed to higher spectrum noise, which is particularly evident at the higher frequency levels. Employees are often unaware of its effects because they are the results of prolonged exposure. Therefore, working in those conditions requires preventive measures and regular testing of the hearing ability. [Mh] Termos MeSH primário: Percepção Auditiva Perda Auditiva Provocada por Ruído/etiologia Perda Auditiva Provocada por Ruído/psicologia Ruído/efeitos adversos Doenças Profissionais/etiologia Exposição Ocupacional/efeitos adversos Pessoas com Deficiência Auditiva/psicologia [Mh] Termos MeSH secundário: Estimulação Acústica Acústica Audiometria Limiar Auditivo Feminino Perda Auditiva Provocada por Ruído/diagnóstico Seres Humanos Estudos Longitudinais Masculino Doenças Profissionais/diagnóstico Doenças Profissionais/psicologia Fatores de Risco Espectrografia do Som Fatores de Tempo [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180213 [Lr] Data última revisão: 180213 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180113 [St] Status: MEDLINE [do] DOI: 10.2298/VSP140416119M

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[PMID]: 29224748 [Au] Autor: Bianchi PM; Bianchi A; Digilio MC; Tucci FM; Sitzia E; De Vincentiis GC [Ad] Endereço: Surgery Department, Otorhinolaryngology Unit, Bambino Gesù Paediatric Hospital, Scientific Research Institute, 00100 Rome, Italy. Electronic address: piermarco.bianchi@opbg.net. [Ti] Título: Audiological findings in a de novo mutation of ANKRD11 gene in KBG syndrome: Report of a case and review of the literature. [So] Source: Int J Pediatr Otorhinolaryngol;103:109-112, 2017 Dec. [Is] ISSN: 1872-8464 [Cp] País de publicação: Ireland [La] Idioma: eng [Ab] Resumo: KBG syndrome is a rare genetic disorder, due to a mutation of ANKRD11, characterized by specific craniofacial dysmorphism, short stature and macrodontia of upper central incisors, intellectual disability and skeletal anomalies. We report a de novo mutation of ANKRD11 gene in a 7-years old girl, affected by KBG syndrome with bilateral conductive hearing loss. The aim of this article was to review the audiological findings of this syndrome. [Mh] Termos MeSH primário: Anormalidades Múltiplas/diagnóstico Doenças do Desenvolvimento Ósseo/diagnóstico Perda Auditiva Condutiva/etiologia Deficiência Intelectual/diagnóstico Proteínas Repressoras/genética Anormalidades Dentárias/diagnóstico [Mh] Termos MeSH secundário: Anormalidades Múltiplas/genética Audiometria Doenças do Desenvolvimento Ósseo/complicações Doenças do Desenvolvimento Ósseo/genética Criança Facies Feminino Seres Humanos Deficiência Intelectual/complicações Deficiência Intelectual/genética Mutação Fenótipo Anormalidades Dentárias/complicações Anormalidades Dentárias/genética [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (ANKRD11 protein, human); 0 (Repressor Proteins) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180104 [Lr] Data última revisão: 180104 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171212 [St] Status: MEDLINE

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[PMID]: 29258540 [Au] Autor: Choi HJ; Lee JS; Yu S; Cha DH; Gee HY; Choi JY; Lee JD; Jung J [Ad] Endereço: Department of Otorhinolaryngology, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, 03722, South Korea. [Ti] Título: Whole-exome sequencing identified a missense mutation in WFS1 causing low-frequency hearing loss: a case report. [So] Source: BMC Med Genet;18(1):151, 2017 12 19. [Is] ISSN: 1471-2350 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: Low-frequency nonsyndromic hearing loss (LF-NSHL) is a rare, inherited disorder. Here, we report a family with LF-NSHL in whom a missense mutation was found in the Wolfram syndrome 1 (WFS1) gene. CASE PRESENTATION: Family members underwent audiological and imaging evaluations, including pure tone audiometry and temporal bone computed tomography. Blood samples were collected from two affected and two unaffected subjects. To determine the genetic background of hearing loss in this family, genetic analysis was performed using whole-exome sequencing. Among 553 missense variants, c.2419A → C (p.Ser807Arg) in WFS1 remained after filtering and inspection of whole-exome sequencing data. This missense mutation segregated with affected status and demonstrated an alteration to an evolutionarily conserved amino acid residue. Audiological evaluation of the affected subjects revealed nonprogressive LF-NSHL, with early onset at 10 years of age, but not to a profound level. CONCLUSION: This is the second report to describe a pathological mutation in WFS1 among Korean patients and the second to describe the mutation in a different ethnic background. Given that the mutation was found in independent families, p.S807R possibly appears to be a "hot spot" in WFS1, which is associated with LF-NSHL. [Mh] Termos MeSH primário: Surdez/genética Perda Auditiva Bilateral/genética Proteínas de Membrana/genética Mutação de Sentido Incorreto/genética [Mh] Termos MeSH secundário: Adolescente Grupo com Ancestrais do Continente Asiático/genética Audiometria Feminino Seres Humanos Masculino Meia-Idade República da Coreia Osso Temporal/diagnóstico por imagem Tomografia Computadorizada por Raios X Sequenciamento Completo do Exoma [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Membrane Proteins); 0 (wolframin protein) [Em] Mês de entrada: 1712 [Cu] Atualização por classe: 171231 [Lr] Data última revisão: 171231 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171221 [St] Status: MEDLINE [do] DOI: 10.1186/s12881-017-0511-7

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[PMID]: 29020061 [Au] Autor: Niklasson M; Norlander T; Niklasson I; Rasmussen P [Ad] Endereço: Center for Research and Development, Evidens University College, Göteborg, Sweden. [Ti] Título: Catching-up: Children with developmental coordination disorder compared to healthy children before and after sensorimotor therapy. [So] Source: PLoS One;12(10):e0186126, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The aims of the present study were to (a) compare healthy children in terms of sensorimotor maturity to untreated children diagnosed with developmental coordination disorder (DCD) and (b) compare healthy children to diagnosed children following completed treatment with sensorimotor therapy. Participants were 298 children, 196 boys and 102 girls, distributed into a Norm group of healthy children (n = 99) and a group of children diagnosed with DCD (n = 199) with a total mean age of 8.77 years (SD = 2.88). Participants in both groups were assessed on instruments aimed to detect sensorimotor deviations. The children in the DCD group completed, during on average 36 months, sensorimotor therapy which comprised stereotypical fetal- and infant movements, vestibular stimulation, tactile stimulation, auditory stimulation, complementary play exercises, gross motor milestones, and sports-related gross motor skills. At the final visit a full assessment was once more performed. Results showed that the Norm group performed better on all sensorimotor tests as compared to the untreated children from the DCD group, with the exception of an audiometric test where both groups performed at the same level. Girls performed better on tests assessing proprioceptive and balance abilities. Results also showed, after controls for natural maturing effects, that the children from the DCD group after sensorimotor therapy did catch up with the healthy children. The concept of "catching-up" is used within developmental medicine but has not earlier been documented with regard to children and youth in connection with DCD. [Mh] Termos MeSH primário: Transtornos das Habilidades Motoras/fisiopatologia Transtornos das Habilidades Motoras/terapia Córtex Sensório-Motor/fisiopatologia [Mh] Termos MeSH secundário: Adolescente Audiometria Estudos de Casos e Controles Criança Pré-Escolar Feminino Seres Humanos Masculino Orientação/fisiologia Equilíbrio Postural/fisiologia Reflexo/fisiologia [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171031 [Lr] Data última revisão: 171031 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171012 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0186126

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[PMID]: 28964301 [Au] Autor: Martínez-Cruz CF; Poblano A; García-Alonso Themann P [Ad] Endereço: Department of Pediatric Follow-up, National Institute of Perinatology, "Dr. Isidro Espinosa de los Reyes", Mexico City, Mexico. Electronic address: drmtzcarlos@yahoo.com.mx. [Ti] Título: Changes in tonal audiometry in children with progressive sensorineural hearing loss and history of Neonatal Intensive Care Unit discharge. A 20 year long-term follow-up. [So] Source: Int J Pediatr Otorhinolaryngol;101:235-240, 2017 Oct. [Is] ISSN: 1872-8464 [Cp] País de publicação: Ireland [La] Idioma: eng [Ab] Resumo: OBJECTIVE: Newborns from Neonatal intensive care units (NICU) are at high-risk for sensorineural hearing loss (SNHL) a follow-up is needed for early diagnosis and intervention. Our objective here was to describe the features and changes of SNHL at different periods during a follow-up of almost 20 years. METHODS: Risk factors for SNHL during development were analyzed. The audiological examination included: Brainstem auditory evoked potentials (BAEP), and Transient evoked otoacoustic emissions (TEOAE). At birth; tonal audiometry (between 125 and 8000 Hz), and tympanometry were performed at 5, 10, 15, and 20 years of age. RESULTS: Sixty-five percent of cases presented bilateral absence of BAEP. At 5 years of age, the most frequent SNHL level was severe (42.5%), followed by moderate (22.5%), and profound level (20%), in all cases, the SNHL was symmetrical with a predominance of lesion for the high frequencies. Exchange transfusion was associated with a higher degree of SNHL (OR = 6.00, CI = 1.11-32.28, p < 0.02). In 55%, SNHL remained stable, but in 40% of the cases it was progressive. At the end of the study six cases with moderate loss progressed to the severe level and seven cases with severe level progressed to profound. CONCLUSIONS: Forty percent of infants with SNHL discharged from NICU may present a progression in the hearing loss. Exchange transfusion was associated with a higher degree of SNHL. NICU graduates with SNHL merit a long-term audiological follow-up throughout their lifespan. [Mh] Termos MeSH primário: Audiometria/métodos Perda Auditiva Neurossensorial/diagnóstico Unidades de Terapia Intensiva Neonatal/estatística & dados numéricos Alta do Paciente/estatística & dados numéricos [Mh] Termos MeSH secundário: Testes de Impedância Acústica/métodos Adolescente Criança Pré-Escolar Potenciais Evocados Auditivos do Tronco Encefálico/fisiologia Feminino Seguimentos Seres Humanos Lactente Recém-Nascido Masculino Triagem Neonatal Emissões Otoacústicas Espontâneas/fisiologia Fatores de Risco Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171016 [Lr] Data última revisão: 171016 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171002 [St] Status: MEDLINE

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[PMID]: 28832812 [Au] Autor: Silva KD; Zuanetti PA; Borcat VTR; Guedes-Granzotti RB; Kuroishi RCS; Domenis DR; Fukuda MTH [Ad] Endereço: Universidade Federal de Sergipe - UFS - Lagarto (SE), Brasil. [Ti] Título: Relation between arithmetic performance and phonological working memory in children. [Ti] Título: Relação entre o desempenho em aritmética e a memória de trabalho fonológica em crianças.. [So] Source: Codas;29(4):e20160128, 2017 Aug 17. [Is] ISSN: 2317-1782 [Cp] País de publicação: Brazil [La] Idioma: por; eng [Ab] Resumo: Purpose: To compare the results of Loop Phonological Working Memory (LPWM) in children without global learning alterations, with lower and average/higher arithmetic performance. Methods: The study was conducted with 30 children, between the ages of seven and nine years old, who attended the second or third grade of elementary school in the public network. Exclusion criteria were children with suggestive signs of hearing loss, neurological disorders, poor performance in the reading comprehension test or in speech therapy. The children included in the study were submitted to the subtest of arithmetic of Academic Achievement Test for division into two groups (G1 and G2). The G1 was composed of children with low performance in arithmetic and G2 for children with average/higher performance in arithmetic. All children were submitted to PWM assessment through the repetition of pseudowords test. Statistical analysis was performed using the Mann-Whitney test and a p-value <0.05 was considered significant. Results: The study included 20 girls and 10 boys, mean age 8.7 years. The G1 was composed of 17 children and G2 of 13 children. There was a statistically significant difference between the groups studied for the repetition of pseudowords with three and four syllables. Conclusion: The results of this study provide support for the hypothesis that changes in phonological working memory are related to difficulties in arithmetic tests. [Mh] Termos MeSH primário: Cognição/fisiologia Matemática Memória de Curto Prazo/fisiologia Fala/fisiologia [Mh] Termos MeSH secundário: Audiometria/métodos Criança Feminino Seres Humanos Testes de Linguagem Masculino Fonética Resolução de Problemas/fisiologia Valores de Referência Estatísticas não Paramétricas Baixo Rendimento Escolar [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171016 [Lr] Data última revisão: 171016 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170824 [St] Status: MEDLINE

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[PMID]: 28807086 [Au] Autor: Hussein A; Fathy H; Amin SM; Elsisy N [Ad] Endereço: Department of Otorhinolaryngology,Faculty of Medicine,Cairo University,Egypt. [Ti] Título: Oral steroids alone or followed by intranasal steroids versus watchful waiting in the management of otitis media with effusion. [So] Source: J Laryngol Otol;131(10):907-913, 2017 Oct. [Is] ISSN: 1748-5460 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: OBJECTIVE: To evaluate the effects of oral steroids alone or followed by intranasal steroids versus watchful waiting on the resolution of otitis media with effusion in children aged 2-11 years. METHODS: A total of 290 children with bilateral otitis media with effusion were assigned to 3 groups: group A was treated with oral steroids followed by intranasal steroids, group B was treated with oral steroids alone and group C was managed with watchful waiting. Patients were evaluated with audiometry and tympanometry. RESULTS: The complete resolution rates of otitis media with effusion were higher in groups A and B than in group C at six weeks. There were no significant differences in otitis media with effusion resolution rates between the groups at three, six and nine months. CONCLUSION: Oral steroids lead only to a quick resolution of otitis media with effusion, with no long-term benefits. There was no benefit of using intranasal steroids in the management of otitis media with effusion. [Mh] Termos MeSH primário: Glucocorticoides/administração & dosagem Otite Média com Derrame/terapia Conduta Expectante/métodos [Mh] Termos MeSH secundário: Testes de Impedância Acústica Administração Intranasal Administração Oral Audiometria Criança Pré-Escolar Feminino Glucocorticoides/uso terapêutico Seres Humanos Masculino Estudos Prospectivos Método Simples-Cego Resultado do Tratamento [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL [Nm] Nome de substância: 0 (Glucocorticoids) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171010 [Lr] Data última revisão: 171010 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170816 [St] Status: MEDLINE [do] DOI: 10.1017/S0022215117001700

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