Base de dados : MEDLINE
Pesquisa : E01.370.386.550 [Categoria DeCS]
Referências encontradas : 1527 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 153 ir para página                         

  1 / 1527 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29278026
[Au] Autor:Tokodi M; Csábi E; Kiricsi Á; Kollár E; Molnár AH; Rovó L; Bella Z
[Ad] Endereço:1 Department of Oto-Rhino-Laryngology and Head-Neck Surgery, University of Szeged , Szeged, Hungary.
[Ti] Título:The effect of nasal provocation with a single-dose allergen on the physical and cognitive performance of patients with ragweed allergy.
[So] Source:Physiol Int;104(4):334-343, 2017 Dec 01.
[Is] ISSN:2498-602X
[Cp] País de publicação:Hungary
[La] Idioma:eng
[Ab] Resumo:Purpose This study aims to compare the impact of active allergic rhinitis on physical and cognitive abilities of trained allergic athletes to untrained allergic patients. Methods Cognitive, respiratory, and fitness functions were assessed before and after allergen exposure. Participants in both groups were provoked intranasally with ragweed allergen. Results The group of athletes revealed significantly higher average values in peak inspiratory flow and fitness index before and after provocation. In neuropsychological assessments, athletes performed significantly better after allergen provocation in complex working memory capacity. Due to single acute allergen exposure, the size of the nasal cavity and nasal inspiratory peak flow significantly decreased in both groups. The physical performance of both groups did not change after provocation. Executive functions and complex working memory capacity of athletes significantly improved resulting from provocation. Conclusions A single-shot allergen in high dose might cause an increase in mental concentration, which was more pronounced in the group of athletes. This study indicates that acute exposure to allergen cannot affect the physical performance and may result in increased mental focus in patients with allergy notwithstanding the declining respiratory functions.
[Mh] Termos MeSH primário: Alérgenos/administração & dosagem
Antígenos de Plantas/administração & dosagem
Desempenho Atlético
Cognição/efeitos dos fármacos
Testes de Provocação Nasal/métodos
Extratos Vegetais/administração & dosagem
Desempenho Psicomotor/efeitos dos fármacos
Rinite Alérgica/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Relação Dose-Resposta a Droga
Esquema de Medicação
Feminino
Seres Humanos
Masculino
Rinite Alérgica/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Antigens, Plant); 0 (Plant Extracts); 0 (ragweed pollen)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171227
[St] Status:MEDLINE
[do] DOI:10.1556/2060.104.2017.4.6


  2 / 1527 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28787729
[Au] Autor:Krajewska-Wojtys A; Jarzab J; Zawadzinska K; Pyrkosz K; Bozek A
[Ad] Endereço:Clinical Department of Internal Diseases, Dermatology, and Allergology, Medical University of Silesia, Zabrze, Poland.
[Ti] Título:Local Allergic Rhinitis in Adult Patients with Chronic Nasal Symptoms.
[So] Source:Int Arch Allergy Immunol;173(3):165-170, 2017.
[Is] ISSN:1423-0097
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Local allergic rhinitis (LAR) remains an underdiagnosed condition characterized by the local production of IgE antibodies during the natural exposure to aeroallergens. The prevalence of LAR in adult patients with a previous diagnosis of non-AR was assessed. MATERIAL AND METHODS: Eighty-four patients with perennial nasal allergy symptoms but a negative skin prick test and specific IgE antibodies against common inhalant allergens were included in the study. Nasal provocation tests were performed with the inhalant allergens Dermatophagoides pteronyssinus, Alternaria, and cat allergen, followed by the detection of nasal-specific IgE antibodies in the lavage during the challenge. RESULTS: LAR was confirmed in 21 (25%) study patients. In the remaining 63 (75%) patients, non-AR was diagnosed. In addition, LAR was found following exposure to D. pteronyssinus in 19 (22.6%) patients, Alternaria in 3 (3.6%) patients, and the cat allergen in 1 (1.2%) patient. In 2 patients, concomitant allergies to D. pteronyssinus and Alternaria were observed. CONCLUSION: LAR can be a form of chronic perennial rhinitis that has previously been considered to be non-AR.
[Mh] Termos MeSH primário: Rinite Alérgica/diagnóstico
Rinite Alérgica/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Alérgenos/imunologia
Alternaria/imunologia
Animais
Antígenos de Dermatophagoides/imunologia
Antígenos de Fungos/imunologia
Gatos/imunologia
Doença Crônica
Feminino
Seres Humanos
Imunoglobulina E/sangue
Imunoglobulina E/imunologia
Masculino
Mucosa Nasal/imunologia
Testes de Provocação Nasal
Prevalência
Rinite Alérgica/sangue
Rinite Alérgica/imunologia
Testes Cutâneos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Antigens, Dermatophagoides); 0 (Antigens, Fungal); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170809
[St] Status:MEDLINE
[do] DOI:10.1159/000478656


  3 / 1527 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28477789
[Au] Autor:Cook KA; Modena BD; Wineinger NE; Woessner KM; Simon RA; White AA
[Ad] Endereço:Division of Allergy, Asthma and Immunology, Scripps Clinic, San Diego, California. Electronic address: cook.kevin@scrippshealth.org.
[Ti] Título:Use of a composite symptom score during challenge in patients with suspected aspirin-exacerbated respiratory disease.
[So] Source:Ann Allergy Asthma Immunol;118(5):597-602, 2017 May.
[Is] ISSN:1534-4436
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Aspirin-exacerbated respiratory disease is characterized by asthma, chronic rhinosinusitis, nasal polyposis, and sensitivity to aspirin and other nonsteroidal anti-inflammatory drugs. Confirmation of the diagnosis requires provocation challenge with resulting upper and/or lower airways reactivity. Currently, determination of a positive challenge result is based solely on clinical judgment that synthesizes subjective symptoms and objective measures, as a concomitant increase in nasal or bronchial airways resistance is measured in only half of patients. OBJECTIVE: To describe a quantitative scoring system, based on symptoms typically reported during provocation challenge, used to identify a positive challenge result. METHODS: A total of 115 patients were asked to record 10 symptoms, rated on a scale from 1 (mild) to 10 (most severe), at regular intervals during intranasal ketorolac with modified oral aspirin challenge performed in our office. Composite scores, a simple sum of all individual scores, were calculated at each time point and compared with baseline, prechallenge values. RESULTS: One hundred of the 115 patients were determined to have a positive challenge result. A statistically significant difference in composite scores was observed in reactors vs nonreactors. All nonreactors recorded an increase in composite score of less than 5, whereas 69% of reactors recorded an increase of 5 or more. CONCLUSION: Our 10-symptom composite score provides a quantitative and comparable measure of symptoms that typically present during a challenge with a positive result. Although an external validation is needed to confirm its diagnostic performance characteristics, a change in composite score of 5 or more appears to be specific to reactors.
[Mh] Termos MeSH primário: Aspirina/efeitos adversos
Hipersensibilidade a Drogas/diagnóstico
Hipersensibilidade a Drogas/imunologia
Fenótipo
Hipersensibilidade Respiratória/diagnóstico
Hipersensibilidade Respiratória/imunologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Imunização
Imunoglobulina E/sangue
Imunoglobulina E/imunologia
Masculino
Meia-Idade
Testes de Provocação Nasal
Testes de Função Respiratória
Sensibilidade e Especificidade
Índice de Gravidade de Doença
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
37341-29-0 (Immunoglobulin E); R16CO5Y76E (Aspirin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170508
[St] Status:MEDLINE


  4 / 1527 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28284536
[Au] Autor:Badorrek P; Müller M; Koch W; Hohlfeld JM; Krug N
[Ad] Endereço:Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany. Electronic address: philipp.badorrek@item.fraunhofer.de.
[Ti] Título:Specificity and reproducibility of nasal biomarkers in patients with allergic rhinitis after allergen challenge chamber exposure.
[So] Source:Ann Allergy Asthma Immunol;118(3):290-297, 2017 Mar.
[Is] ISSN:1534-4436
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Allergic rhinitis is an inflammatory disease that causes cellular influx and mediator release in the nose. These inflammatory changes might be used as nasal biomarkers to assess the efficacy of novel anti-allergic treatments. OBJECTIVE: To assess the specificity and reproducibility of nasal biomarkers in patients with allergic rhinitis after grass pollen exposure in an allergen challenge chamber. METHODS: In a monocenter pilot study, 15 patients with allergic rhinitis and 19 healthy individuals underwent two 4-hour Dactylis glomerate pollen challenges in the challenge chamber with an interval of 21 days. Before challenge, on exit, and after 2 and 22 hours, a nasal lavage was performed and nasal secretions were collected on filter paper to determine a wide panel of cells and mediators. Furthermore, total nasal symptom score, nasal flow, and nasal nitric oxide were measured. RESULTS: Pollen exposure significantly increased eosinophil, interleukin (IL) 5, IL-6, IL-13, and macrophage inflammatory protein 1ß levels in allergic patients but not in healthy individuals. The effect could be reproduced for eosinophils, IL-5, IL-6, and macrophage inflammatory protein 1ß after the second allergen challenge. By contrast, the IL-13 levels were higher and eotaxin levels first increased after repetitive allergen challenge. There was no correlation between total nasal symptom score and elevated cell or cytokine levels. Nasal nitric oxide levels were nonspecifically elevated in both patients with allergy and healthy controls. CONCLUSION: A subset of cellular and soluble biomarkers in nasal lavage and secretion reveals specificity and reproducibility in patients with allergic rhinitis. These can be used to measure the immunologic efficacy of antiallergic treatments in an allergen challenge chamber. Carryover effects attributable to priming must be considered when designing cross-over studies. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00297843.
[Mh] Termos MeSH primário: Alérgenos/imunologia
Biomarcadores
Mucosa Nasal/imunologia
Mucosa Nasal/metabolismo
Rinite Alérgica/imunologia
Rinite Alérgica/metabolismo
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Citocinas/metabolismo
Feminino
Seres Humanos
Imunização
Mediadores da Inflamação/metabolismo
Contagem de Leucócitos
Masculino
Líquido da Lavagem Nasal/imunologia
Testes de Provocação Nasal
Óxido Nítrico/metabolismo
Projetos Piloto
Pólen/imunologia
Rinite Alérgica/diagnóstico
Rinomanometria
Índice de Gravidade de Doença
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Biomarkers); 0 (Cytokines); 0 (Inflammation Mediators); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170313
[St] Status:MEDLINE


  5 / 1527 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Solé, Dirceu
Texto completo
[PMID]:28234142
[Au] Autor:Matsumoto FY; Gonçalves TR; Solé D; Wandalsen GF
[Ad] Endereço:Division of Allergy, Clinical Immunology and Rheumatology, Department of Pediatrics, Federal University of São Paulo, São Paulo, Brazil.
[Ti] Título:Specific nasal provocation test with , monitored by acoustic rhinometry, in children with rhinitis.
[So] Source:Am J Rhinol Allergy;31(1):7-11, 2017 Jan 01.
[Is] ISSN:1945-8932
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Currently, the diagnosis of allergic rhinitis (AR) is arrived at predominantly by a clinical history and by systemic sensitization tests, but specific nasal provocation tests (NPT) may establish a better direct correlation between etiologic surveyed allergens and nasal symptoms. OBJECTIVES: To standardize the specific NPT with one of the most important house-dust mites, Dermatophagoides pteronyssinus, monitored by acoustic rhinometry, in children and adolescents, and propose a simplified specific NPT to improve its clinical applicability as a diagnostic tool. METHODS: Sixteen controls (group 1) and 17 patients with an AR diagnosis sensitized to D. pteronyssinus (group 2) underwent a specific NPT with D. pteronyssinus. The acoustic rhinometry was performed after instillation of 0.15 mL of increasing concentrations of D. pteronyssinus (5000 BU/mL). The test was finalized after (1) instillation of the final concentration of D. pteronyssinus, or (2) after a 20% or more reduction in the volume of the first 5 cm of the nasal cavity (V5), or (3) a score of >3 in the symptoms questionnaire (a score from 0 to 7). A simplified specific NPT with two concentrations was proposed and implemented in a group of 10 patients with AR (group 3). RESULTS: At the end of the specific NPT, the median (range) variation in V5 was -5.7% (-9 to 4%) in the control group and -22.8% (-24 to -20%) in group 2. None of the patients in the control group and 88% of group 2 (15/17) showed positive specific NPT results. The simplified specific NPT triggered a positive response in 80% of patients in group 3, with median (range) V5 variation of -30.4% (-36 to -20%). CONCLUSION: This protocol has been proven safe and useful to differentiate between children and adolescents with AR and controls. Concentrations of 1:1000 and 1:100 D. pteronyssinus were the best for use in simplified specific NPT, which made it simpler and faster, and expanded its clinical applicability.
[Mh] Termos MeSH primário: Testes de Provocação Nasal/métodos
Rinite Alérgica/diagnóstico
Rinometria Acústica/métodos
[Mh] Termos MeSH secundário: Adolescente
Animais
Antígenos de Dermatophagoides/imunologia
Criança
Dermatophagoides pteronyssinus/imunologia
Feminino
Seres Humanos
Imunização
Imunoglobulina E/sangue
Masculino
Rinite Alérgica/imunologia
Testes Cutâneos
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Dermatophagoides); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170421
[Lr] Data última revisão:
170421
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170225
[St] Status:MEDLINE
[do] DOI:10.2500/ajra.2017.31.4392


  6 / 1527 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:28031122
[Au] Autor:Liu Y; Chen Y; Zheng J; Wang S
[Ad] Endereço:Department of Allergy, Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China.
[Ti] Título:[Increased eosinophils in nasal exudation after allergic rhinitis nasal provocation are positively correlated with serum level of specific IgE].
[So] Source:Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi;33(1):85-88, 2017 Jan.
[Is] ISSN:1007-8738
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:Objective To study the relationship between specific nasal provocation test (SNPT) and serum specific IgE level in the patients with allergic rhinitis, and analyze the correlation between the eosinophil (EOS) percentage in nasal secretion and serum specific IgE level. Methods SNPT was performed in 80 cases of perennial allergic rhinitis due to dust mites. Specific IgE in the serum of those patients was detected by Unicap. EOS percentage in nasal secretions was recorded before and after SNPT. The correlation of EOS percentage and serum level of specific IgE was analyzed by Kendall's tau-b test. Results The positive result of SNPT had a concordance with serum specific IgE in recruited patients. And the increased EOS percentage in nasal secretions after SNPT had a positive correlation with the level of serum specific IgE. Conclusion Positive SNPT can be used as a diagnostic index of allergic rhinitis. And the increased percentage of EOS in nasal secretions after SNPT can also help evaluate the severity of allergic rhinitis.
[Mh] Termos MeSH primário: Eosinófilos/imunologia
Imunoglobulina E/sangue
Mucosa Nasal/imunologia
Rinite Alérgica/imunologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Feminino
Seres Humanos
Masculino
Meia-Idade
Testes de Provocação Nasal/métodos
Rinite Alérgica/sangue
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161230
[St] Status:MEDLINE


  7 / 1527 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27915210
[Au] Autor:Metzger FG; Ehlis AC; Haeussinger FB; Schneeweiss P; Hudak J; Fallgatter AJ; Schneider S
[Ad] Endereço:Department of Psychiatry and Psychotherapy, University Hospital of Tuebingen, Calwerstraße 14, 72076 Tuebingen, Germany; Geriatric Center, University Hospital of Tuebingen, Calwerstraße 14, 72076 Tuebingen, Germany. Electronic address: florian.Metzger@med.uni-tuebingen.de.
[Ti] Título:Functional brain imaging of walking while talking - An fNIRS study.
[So] Source:Neuroscience;343:85-93, 2017 Feb 20.
[Is] ISSN:1873-7544
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Since functional imaging of whole body movements is not feasible with functional magnetic resonance imaging (fMRI), the present study presents in vivo functional near-infrared spectroscopy (fNIRS) as a suitable technique to measure body movement effects on fronto-temporo-parietal cortical activation in single- and dual-task paradigms. Previous fNIRS applications in studies addressing whole body movements were typically limited to the assessment of prefrontal brain areas. The current study investigated brain activation in the frontal, temporal and parietal cortex of both hemispheres using functional near-infrared spectroscopy (fNIRS) with two large 4×4 probe-sets with 24 channels each during single and dual gait tasks. 12 young healthy adults were measured using fNIRS walking on a treadmill: the participants performed two single-task (ST) paradigms (walking at different speeds, i.e. 3 and 5km/h) and a dual task (DT) paradigm where a verbal fluency task (VFT) had to be executed while walking at 3km/h. The results show an increase of activation in Broca's area during the more advanced conditions (ST 5km/h vs. ST 3km/h, DT vs. ST 3km/h, DT vs. 5km/h), while the corresponding area on the right hemisphere was also activated. DT paradigms including a cognitive task in conjunction with whole body movements elicit wide-spread cortical activation patterns across fronto-temporo-parietal areas. An elaborate assessment of these activation patterns requires more extensive fNIRS assessments than the traditional prefrontal investigations, e.g. as performed with portable fNIRS devices.
[Mh] Termos MeSH primário: Córtex Cerebral/fisiologia
Fala/fisiologia
Caminhada/fisiologia
[Mh] Termos MeSH secundário: Adulto
Estudos de Viabilidade
Feminino
Neuroimagem Funcional
Seres Humanos
Masculino
Testes de Provocação Nasal
Projetos Piloto
Espectroscopia de Luz Próxima ao Infravermelho
Caminhada/psicologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161205
[St] Status:MEDLINE


  8 / 1527 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27758759
[Au] Autor:Quiralte-Castillo J; Ávila-Castellano MR; Cimbollek S; Benaixa P; Leguisamo S; Baynova K; Labella M; Quiralte J
[Ad] Endereço:Allergy Section, Hospital Universitario Virgen del Rocío, Sevilla, Spain.
[Ti] Título:Nasal Ketorolac Challenge Using Acoustic Rhinometry in Patients With Aspirin-Exacerbated Respiratory Disease.
[So] Source:J Investig Allergol Clin Immunol;27(3):169-174, 2017.
[Is] ISSN:1018-9068
[Cp] País de publicação:Spain
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVE: Safer and less time-consuming alternatives to single-blind placebo-controlled oral challenge (SBPCOC) have been sought for the diagnosis of aspirin-exacerbated respiratory disease (AERD). Nasal challenges with various nonsteroidal anti-inflammatory drugs and assessment methods have been developed. Objective: Our objective was to evaluate the utility and safety of nasal ketorolac challenge (NKC) using acoustic rhinometry in patients with suspected AERD. METHODS: The study population comprised 36 patients with suspected AERD. NKC was performed with placebo (saline) and 13 mg of ketorolac sprayed as aerosol into both nostrils. A positive challenge result was defined as an increase of ≥30% in nasal symptoms (recorded using a visual analog scale) and a 30% drop in the sum of the volumes of both nasal cavities at 2-8 cm. Patients with a negative NKC result underwent SBPCOC with aspirin (cumulative dose of 750 mg). RESULTS: A naso-ocular reaction during NKC was detected in 21 patients. Four patients also developed mild asthma exacerbations (although only 1 experienced a decrease in FEV1 >15%). No other significant adverse events occurred. The remaining 15 patients with a negative NKC result had a negative response during aspirin SBPCOC. CONCLUSIONS: NKC assessed using acoustic rhinometry is a reliable method for the study of patients with AERD. We suggest that NKC assessed with acoustic rhinometry was useful and safe for selection of candidates for safe oral aspirin challenge.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides
Asma Induzida por Aspirina/diagnóstico
Cetorolaco
Testes de Provocação Nasal/métodos
Rinometria Acústica/métodos
[Mh] Termos MeSH secundário: Administração Intranasal
Adolescente
Adulto
Idoso
Asma Induzida por Aspirina/fisiopatologia
Feminino
Volume Expiratório Forçado
Seres Humanos
Masculino
Meia-Idade
Cavidade Nasal
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); YZI5105V0L (Ketorolac)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161021
[St] Status:MEDLINE
[do] DOI:10.18176/jiaci.0118


  9 / 1527 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27822506
[Au] Autor:Webber ES; Mankin DE; Cromwell HC
[Ad] Endereço:Department of Psychology, Bowling Green State University, Bowling Green, Ohio 43403; J.P. Scott Center for Neuroscience, Mind & Behavior, Bowling Green State University, Bowling Green, Ohio 43403.
[Ti] Título:Striatal Activity and Reward Relativity: Neural Signals Encoding Dynamic Outcome Valuation.
[So] Source:eNeuro;3(5), 2016 Sep-Oct.
[Is] ISSN:2373-2822
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The striatum is a key brain region involved in reward processing. Striatal activity has been linked to encoding reward magnitude and integrating diverse reward outcome information. Recent work has supported the involvement of striatum in the valuation of outcomes. The present work extends this idea by examining striatal activity during dynamic shifts in value that include different levels and directions of magnitude disparity. A novel task was used to produce diverse relative reward effects on a chain of instrumental action. Rats ( ) were trained to respond to cues associated with specific outcomes varying by food pellet magnitude. Animals were exposed to single-outcome sessions followed by mixed-outcome sessions, and neural activity was compared among identical outcome trials from the different behavioral contexts. Results recording striatal activity show that neural responses to different task elements reflect incentive contrast as well as other relative effects that involve generalization between outcomes or possible influences of outcome variety. The activity that was most prevalent was linked to food consumption and post-food consumption periods. Relative encoding was sensitive to magnitude disparity. A within-session analysis showed strong contrast effects that were dependent upon the outcome received in the immediately preceding trial. Significantly higher numbers of responses were found in ventral striatum linked to relative outcome effects. Our results support the idea that relative value can incorporate diverse relationships, including comparisons from specific individual outcomes to general behavioral contexts. The striatum contains these diverse relative processes, possibly enabling both a higher information yield concerning value shifts and a greater behavioral flexibility.
[Mh] Termos MeSH primário: Corpo Estriado/fisiologia
Neurônios/fisiologia
Recompensa
[Mh] Termos MeSH secundário: Potenciais de Ação
Animais
Condicionamento Operante/fisiologia
Discriminação (Psicologia)/fisiologia
Ingestão de Alimentos/fisiologia
Ingestão de Alimentos/psicologia
Eletrodos Implantados
Alimentos
Generalização (Psicologia)/fisiologia
Masculino
Testes de Provocação Nasal
Ratos Sprague-Dawley
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161109
[St] Status:MEDLINE


  10 / 1527 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27788883
[Au] Autor:Tiotiu A; Brazdova A; Longé C; Gallet P; Morisset M; Leduc V; Hilger C; Broussard C; Couderc R; Sutra JP; Sénéchal H; Poncet P
[Ad] Endereço:Pneumology-Allergology Department, University Hospital, Nancy, France.
[Ti] Título:Urtica dioica pollen allergy: Clinical, biological, and allergomics analysis.
[So] Source:Ann Allergy Asthma Immunol;117(5):527-534, 2016 Nov.
[Is] ISSN:1534-4436
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The most emblematic members of Urticaceae at allergic risk level are wall pellitories (Parietaria), whereas nettle (Urtica) pollen is considered as poorly allergenic. No allergen from nettle pollen has yet been characterized, whereas 4 are listed for Parietaria pollen by the International Union of Immunological Societies. Clinical and biological profiles of 2 adult men who developed symptoms against nettle pollen and/or leaves were studied. OBJECTIVE: To characterize the allergic reaction and identify the potential nettle pollen sensitizing allergens. METHODS: IgE-mediated reaction to nettle pollen extract was evaluated by skin prick test, immunoassay, nasal provocation, and basophil activation test. To characterize specific nettle pollen allergens, an allergomic (IgE immunoproteomic) analysis was performed combining 1- and 2-dimensional electrophoresis, IgE immunoblots of nettle pollen extract, identification of allergens by mass spectrometry, and database queries. RESULTS: The results of biological and immunochemical analyses revealed that the allergic rhinitis was due to Urtica dioica pollen in both patients. The allergomic analysis of nettle pollen extract allowed the characterization of 4 basic protein allergens: a thaumatin-like protein (osmotin) with a relative molecular mass of 27 to 29 kDa, a pectinesterase (relative molecular mass, 40 kDa), and 2 other basic proteins with relative molecular masses of 14 to 16 kDa and 43 kDa. There is no or only very weak allergen associations between pellitory and nettle pollen. CONCLUSION: Exposure to nettle pollen can be responsible of allergic symptoms, and several allergens were characterized. Unravelling the allergens of this underestimated allergy might help to improve diagnosis and care for patients, to predict cross-reactivities and design adapted specific immunotherapy.
[Mh] Termos MeSH primário: Alérgenos/imunologia
Conjuntivite/imunologia
Pólen/imunologia
Rinite Alérgica Sazonal/imunologia
Urtica dioica/imunologia
[Mh] Termos MeSH secundário: Conjuntivite/sangue
Seres Humanos
Imunoglobulina E/imunologia
Masculino
Meia-Idade
Testes de Provocação Nasal
Rinite Alérgica Sazonal/sangue
Testes Cutâneos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161030
[St] Status:MEDLINE



página 1 de 153 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde