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[PMID]:29337391
[Au] Autor:Ishii T; Niikura Y; Kurata K; Muroi M; Tanamoto K; Nagase T; Sakaguchi M; Yamashita N
[Ad] Endereço:Department of Pharmacotherapy, Research Institute of Pharmaceutical Sciences, Musashino University, Tokyo, Japan.
[Ti] Título:Time-dependent distinct roles of Toll-like receptor 4 in a house dust mite-induced asthma mouse model.
[So] Source:Scand J Immunol;87(3), 2018 Mar.
[Is] ISSN:1365-3083
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:House dust mites (HDMs) are a common source of allergens that trigger both allergen-specific and innate immune responses in humans. Here, we examined the effect of allergen concentration and the involvement of Toll-like receptor 4 (TLR4) in the process of sensitization to house dust mite allergens in an HDM extract-induced asthma mouse model. Intranasal administration of HDM extract induced an immunoglobulin E response and eosinophilic inflammation in a dose-dependent manner from 2.5 to 30 µg/dose. In TLR4-knockout mice, the infiltration of eosinophils and neutrophils into the lung was decreased compared with that in wild-type mice in the early phase of inflammation (total of three doses). However, in the late phase of inflammation (total of seven doses), eosinophil infiltration was significantly greater in TLR4-knockout mice than in wild-type mice. This suggests that the roles of TLR4 signaling are different between the early phase and the later phase of HDM allergen-induced inflammation. Thus, innate immune response through TLR4 regulated the response to HDM allergens, and the regulation was altered during the phase of inflammation.
[Mh] Termos MeSH primário: Alérgenos/imunologia
Antígenos de Dermatophagoides/imunologia
Asma/imunologia
Imunidade Inata/imunologia
Pyroglyphidae/imunologia
Receptor 4 Toll-Like/imunologia
[Mh] Termos MeSH secundário: Resistência das Vias Respiratórias/imunologia
Animais
Líquido da Lavagem Broncoalveolar/citologia
Modelos Animais de Doenças
Eosinófilos/patologia
Feminino
Imunização
Imunoglobulina E/imunologia
Inflamação/imunologia
Pulmão/citologia
Pulmão/imunologia
Pulmão/patologia
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Infiltração de Neutrófilos/imunologia
Neutrófilos/patologia
Transdução de Sinais/imunologia
Receptor 4 Toll-Like/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Antigens, Dermatophagoides); 0 (Tlr4 protein, mouse); 0 (Toll-Like Receptor 4); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE
[do] DOI:10.1111/sji.12641


  2 / 12897 MEDLINE  
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[PMID]:29360426
[Au] Autor:Di Vece L; Doldo T; Faleri G; Picciotti M; Salerni L; Ugolini A; Goracci C
[Ti] Título:Rhinofibroscopic and Rhinomanometric Evaluation of Patients with Maxillary Contraction Treated with Rapid Maxillary Expansion. A Prospective Pilot Study.
[So] Source:J Clin Pediatr Dent;42(1):27-31, 2018.
[Is] ISSN:1053-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The aim of this study was to evaluate through nasal fiber optic endoscopy and rhinomanometry the patency of upper nasal airways in patients treated with rapid palatal expansion Study design: 30 patients (12 males and 18 females) aged 7-11 years with transverse maxillary constriction underwent rhinomanometric and fiberoptic examination before (T0) and after rapid palatal expansion (T1).The amount of nasopharynx obstruction was quantified with reference to the full choanal surface. Nasal resistance was recorded separately for right and left sides, and combined for both sides. The differences in nasopharynx obstruction and in nasal resistance between T0 and T1 were statistically evaluated. RESULTS: The amount of nasopharynx obstruction significantly decreased after palatal expansion (p<0.001). Total nasal inspiration and expiration resistance significantly decreased at T1 (p<0.001). The reduction ranged between 0. 23 and 0. 66 Pa/cm /s for inspiration and between 0. 20 and 0,.58 Pa/cm /s for expiration. A statistically significant positive correlation existed between the T1-T0 differences in the amount of nasopharynx obstruction and the T1-T0 differences in expiration nasal airway resistance (Spearman's correlation coefficient rho = 0.38; p = 0.03). CONCLUSIONS: Rapid maxillary expansion has an influence on nasal resistance and improves the patency of upper airways in patients with minor or moderate breathing problems.
[Mh] Termos MeSH primário: Endoscopia
Técnica de Expansão Palatina
Rinomanometria
[Mh] Termos MeSH secundário: Resistência das Vias Respiratórias/fisiologia
Criança
Feminino
Seres Humanos
Masculino
Obstrução Nasal/terapia
Projetos Piloto
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:180124
[St] Status:MEDLINE
[do] DOI:10.17796/1053-4628-42.1.5


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[PMID]:29365388
[Au] Autor:Zhou YQ; Ye JY
[Ad] Endereço:Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
[Ti] Título:[Neuromuscular properties of genioglossus activity in healthy adults and obstructive sleep apnea patients].
[So] Source:Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi;53(1):70-72, 2018 Jan 07.
[Is] ISSN:1673-0860
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:Upper airway patency closely contact with neuromuscular airway regulation during respiratory, especially the activity of the pharyngeal dilators. The genioglossus is the largest pharyngeal dilators with its contraction playing the most important role in keeping the pharyngeal airway open. In healthy individuals, genioglossus activation shows a negative correlation with pharyngeal collapsibility and upper airway resistance. Negative pressure during inspiration can stimulate airway mechanoreceptors to produce a muscle reflex activity. However, in obstructive sleep apnea (OSA) patients, the muscles cannot always compensate for the increased mechanical load, resulting in frequent obstructive breathing events. A number of studies have shown that the collapsibility of upper airway during sleep in OSA patients is closely related to the activity of genioglossus electromyography(GGEMG). The present article describes the current understanding regarding the characters of GGEMG during sleep in healthy adults, as well as the pathophysiology of GGEMG in OSA patients.
[Mh] Termos MeSH primário: Músculos Faríngeos/fisiologia
Apneia Obstrutiva do Sono/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Resistência das Vias Respiratórias/fisiologia
Eletromiografia
Seres Humanos
Masculino
Músculos Faríngeos/fisiopatologia
Respiração
Sono/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1673-0860.2018.01.018


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[PMID]:28651794
[Au] Autor:Genta PR; Sands SA; Butler JP; Loring SH; Katz ES; Demko BG; Kezirian EJ; White DP; Wellman A
[Ad] Endereço:Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Pulmonary Division, Heart Institute (InCor), Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil. Electronic address: p
[Ti] Título:Airflow Shape Is Associated With the Pharyngeal Structure Causing OSA.
[So] Source:Chest;152(3):537-546, 2017 Sep.
[Is] ISSN:1931-3543
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: OSA results from the collapse of different pharyngeal structures (soft palate, tongue, lateral walls, and epiglottis). The structure involved in collapse has been shown to impact non-CPAP OSA treatment. Different inspiratory airflow shapes are also observed among patients with OSA. We hypothesized that inspiratory flow shape reflects the underlying pharyngeal structure involved in airway collapse. METHODS: Subjects with OSA were studied with a pediatric endoscope and simultaneous nasal flow and pharyngeal pressure recordings during natural sleep. The mechanism causing collapse was classified as tongue-related, isolated palatal, lateral walls, or epiglottis. Flow shape was classified according to the degree of negative effort dependence (NED), defined as the percent reduction in inspiratory flow from peak to plateau. RESULTS: Thirty-one subjects with OSA (mean apnea-hypopnea index score ± SD, 54 ± 27 events/h) who were 50 ± 9 years of age were studied. NED was associated with the structure causing collapse (P < .001). Tongue-related obstruction (n = 13) was associated with a small amount of NED (median, 19; interquartile range [IQR], 14%-25%). Moderate NED was found among subjects with isolated palatal collapse (median, 45; IQR, 39%-52%; n = 8) and lateral wall collapse (median, 50; IQR, 44%-64%; n = 8). The epiglottis was associated with severe NED (median, 89; IQR, 78%-91%) and abrupt discontinuities in inspiratory flow (n = 9). CONCLUSIONS: Inspiratory flow shape is influenced by the pharyngeal structure causing collapse. Flow shape analysis may be used as a noninvasive tool to help determine the pharyngeal structure causing collapse.
[Mh] Termos MeSH primário: Inalação/fisiologia
Faringe/patologia
Apneia Obstrutiva do Sono/etiologia
Apneia Obstrutiva do Sono/patologia
[Mh] Termos MeSH secundário: Adulto
Resistência das Vias Respiratórias/fisiologia
Broncoscopia
Epiglote/patologia
Epiglote/fisiopatologia
Feminino
Seres Humanos
Capacidade Inspiratória
Masculino
Pressões Respiratórias Máximas
Meia-Idade
Palato/patologia
Palato/fisiopatologia
Faringe/fisiopatologia
Apneia Obstrutiva do Sono/fisiopatologia
Língua/patologia
Língua/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE


  5 / 12897 MEDLINE  
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[PMID]:28539354
[Au] Autor:Kay VL; Sprick JD; Rickards CA
[Ad] Endereço:Institute for Cardiovascular and Metabolic Diseases, University of North Texas Health Science Center, Fort Worth, Texas.
[Ti] Título:Cerebral oxygenation and regional cerebral perfusion responses with resistance breathing during central hypovolemia.
[So] Source:Am J Physiol Regul Integr Comp Physiol;313(2):R132-R139, 2017 Aug 01.
[Is] ISSN:1522-1490
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Resistance breathing improves tolerance to central hypovolemia induced by lower body negative pressure (LBNP), but this is not related to protection of anterior cerebral blood flow [indexed by mean middle cerebral artery velocity (MCAv)]. We hypothesized that inspiratory resistance breathing improves tolerance to central hypovolemia by maintaining cerebral oxygenation (ScO ), and protecting cerebral blood flow in the posterior cerebral circulation [indexed by posterior cerebral artery velocity (PCAv)]. Eight subjects (4 male/4 female) completed two experimental sessions of a presyncopal-limited LBNP protocol (3 mmHg/min onset rate) with and without (Control) resistance breathing via an impedance threshold device (ITD). ScO (via near-infrared spectroscopy), MCAv and PCAv (both via transcranial Doppler ultrasound), and arterial pressure (via finger photoplethysmography) were measured continuously. Hemodynamic responses were analyzed between the Control and ITD condition at baseline (T1) and the time representing 10 s before presyncope in the Control condition (T2). While breathing on the ITD increased LBNP tolerance from 1,506 ± 75 s to 1,704 ± 88 s ( = 0.003), both mean MCAv and mean PCAv were similar between conditions at T2 ( ≥ 0.46), and decreased by the same magnitude with and without ITD breathing ( ≥ 0.53). ScO also decreased by ~9% with or without ITD breathing at T2 ( = 0.97), and there were also no differences in deoxygenated (dHb) or oxygenated hemoglobin (HbO ) between conditions at T2 ( ≥ 0.43). There was no evidence that protection of regional cerebral blood velocity (i.e., anterior or posterior cerebral circulation) nor cerebral oxygen extraction played a key role in the determination of tolerance to central hypovolemia with resistance breathing.
[Mh] Termos MeSH primário: Resistência das Vias Respiratórias
Velocidade do Fluxo Sanguíneo
Volume Sanguíneo
Encéfalo/metabolismo
Circulação Cerebrovascular
Hipovolemia/fisiopatologia
Oxigênio/sangue
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Consumo de Oxigênio
Mecânica Respiratória
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
S88TT14065 (Oxygen)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1152/ajpregu.00385.2016


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[PMID]:28483609
[Au] Autor:Zider AD; Wang X; Buhr RG; Sirichana W; Barjaktarevic IZ; Cooper CB
[Ad] Endereço:Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA.
[Ti] Título:Reduced COPD Exacerbation Risk Correlates With Improved FEV : A Meta-Regression Analysis.
[So] Source:Chest;152(3):494-501, 2017 Sep.
[Is] ISSN:1931-3543
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The mechanism by which various classes of medication reduce COPD exacerbation risk remains unknown. We hypothesized a correlation between reduced exacerbation risk and improvement in airway patency as measured according to FEV . METHODS: By systematic review, COPD trials were identified that reported therapeutic changes in predose FEV (dFEV ) and occurrence of moderate to severe exacerbations. Using meta-regression analysis, a model was generated with dFEV as the moderator variable and the absolute difference in exacerbation rate (RD), ratio of exacerbation rates (RRs), or hazard ratio (HR) as dependent variables. RESULTS: The analysis of RD and RR included 119,227 patients, and the HR analysis included 73,475 patients. For every 100-mL change in predose FEV , the HR decreased by 21% (95% CI, 17-26; P < .001; R = 0.85) and the absolute exacerbation rate decreased by 0.06 per patient per year (95% CI, 0.02-0.11; P = .009; R = 0.05), which corresponded to an RR of 0.86 (95% CI, 0.81-0.91; P < .001; R = 0.20). The relationship with exacerbation risk remained statistically significant across multiple subgroup analyses. CONCLUSIONS: A significant correlation between increased FEV and lower COPD exacerbation risk suggests that airway patency is an important mechanism responsible for this effect.
[Mh] Termos MeSH primário: Doença Pulmonar Obstrutiva Crônica/complicações
Doença Pulmonar Obstrutiva Crônica/fisiopatologia
[Mh] Termos MeSH secundário: Resistência das Vias Respiratórias/fisiologia
Progressão da Doença
Volume Expiratório Forçado/fisiologia
Seres Humanos
Análise de Regressão
Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170510
[St] Status:MEDLINE


  7 / 12897 MEDLINE  
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[PMID]:28399782
[Au] Autor:Zhang C; Song Y; Wang C; Zhao L; Kang H; Ma X; Wang J; Zhang T; Shumin W; Ma C
[Ad] Endereço:a Department of Cardiology , the Second Affiliated Hospital, Medical School of Xi?an Jiaotong University , Xi'an , P.R. China.
[Ti] Título:The effects of chrysophanol on ovalbumin (OVA)-induced chronic lung toxicology by inhibiting Th17 response.
[So] Source:Toxicol Mech Methods;27(5):327-334, 2017 Jun.
[Is] ISSN:1537-6524
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Chrysophanol (CH), extracted from plants of Rheum genus, possesses various pharmacological effects including anti-inflammatory activity. The purpose of the present study was to evaluate the protective effects and the underlying mechanisms of CH on ovalbumin (OVA)-induced asthma in mice. Fifty mice were randomly assigned to five experimental groups: control group, model group, dexamethasone (2 mg/kg) group and CH (5 and 10 mg/kg) groups. The number of eosinophil cells and the production of interleukin-6 (IL-6), IL-1ß, IL-17 A and tumor necrosis factor-α in bronchoalveolar lavage fluid (BALF) were measured. In addition, pulmonary histopathology, airway resistance (Raw), T-helper17 (Th17) cells frequency and RORγt expression were evaluated. Our study demonstrated that CH effectively decreased eosinophil count and inflammatory cytokines production in BALF. In addition, treatment with CH significantly inhibited the Raw, Th17 percentage and RORγt expression in OVA-induced animals compared with those in model group. Histological studies also demonstrated that CH significantly suppressed OVA-induced eosinophilia in lung tissue compared with model group. Our findings supported that CH can prevent allergic asthma in the mouse model.
[Mh] Termos MeSH primário: Antraquinonas/uso terapêutico
Anti-Inflamatórios/uso terapêutico
Asma/tratamento farmacológico
Ovalbumina/imunologia
Células Th17/efeitos dos fármacos
[Mh] Termos MeSH secundário: Resistência das Vias Respiratórias/efeitos dos fármacos
Resistência das Vias Respiratórias/imunologia
Animais
Antraquinonas/administração & dosagem
Antraquinonas/isolamento & purificação
Anti-Inflamatórios/administração & dosagem
Anti-Inflamatórios/isolamento & purificação
Asma/imunologia
Líquido da Lavagem Broncoalveolar/citologia
Líquido da Lavagem Broncoalveolar/imunologia
Citocinas/metabolismo
Modelos Animais de Doenças
Feminino
Citometria de Fluxo
Camundongos Endogâmicos BALB C
Rheum/química
Células Th17/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthraquinones); 0 (Anti-Inflammatory Agents); 0 (Cytokines); 9006-59-1 (Ovalbumin); N1ST8V8RR2 (chrysophanic acid)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170413
[St] Status:MEDLINE
[do] DOI:10.3109/15376516.2015.1053653


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[PMID]:28364453
[Au] Autor:Sankari A; Pranathiageswaran S; Maresh S; Hosni AM; Badr MS
[Ad] Endereço:Sleep research Laboratory, Division of Pulmonary, Critical Care, and Sleep Medicine, John D. Dingell VA Medical Center & Wayne State University, Detroit, MI.
[Ti] Título:Characteristics and Consequences of Non-apneic Respiratory Events During Sleep.
[So] Source:Sleep;40(1), 2017 Jan 01.
[Is] ISSN:1550-9109
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Rationale: Current scoring criteria of non-apneic events (ie, hypopnea) require the presence of oxyhemoglobin desaturation and/or arousal. However, other sleep study parameters may help to identify abnormal respiratory events (REs) and assist in making more accurate diagnosis. Objectives: To investigate whether non-apneic REs without desaturation or cortical arousal are associated with respiratory and cardiac consequences. Methods: Thirteen participants with sleep disturbances (snoring and/or excessive day time sleepiness), were screened using attended in laboratory polysomnography (PSG) while monitoring pressure and airflow via a nasal mask with an attached pneumotach. To separate the contribution of the upper airway resistance (RUA) and total pulmonary resistance (RL), supraglottic and esophageal pressures were measured using Millar pressure catheters. RL and RUA were calculated during baseline and hypopneas. RL was defined as the resistive pressure divided by the maximal flow during inspiration and expiration. Hypopnea was defined 30% decrease in flow with 3% desaturation and/or cortical arousal. REs was defined as 30% decrease in the flow without desaturation and/or cortical arousal. In eight subjects continuous positive airway pressure (CPAP) was titrated to optimal pressure. R-R interval (RRI) was defined as consecutive beat-to-beat intervals on single lead electrocardiograph (ECG) during baseline, RE/hypopnea and on optimal CPAP. Results: REs associated with increased expiratory RUA (14.6 ± 11.3 vs. 7.5 ± 4.5 cmH2O L-1 s-1; p < .05), and increased expiratory RL relative to baseline (29.2 ± 14.6 vs. 20.9 ± 11.0 and 23.7 ± 12.1 vs. 14.3 ± 5.6 cmH2O L-1 s-1 during inspiration and expiration, respectively; p < .05). RRI decreased significantly following RE and hypopnea relative to baseline (804.8 ± 33.1 vs. 806.4 ± 36.3 vs. 934.3 ± 45.8 ms; p < .05). Optimal CPAP decreased expiratory RUA (4.0 ± 2.5 vs. 7.5 ± 4.5 cmH2O L-1 s-1; p < .05), decreased inspiratory RL (12.6 ± 14.1 vs. 7.5 ± 4.5 cmH2O L-1 s-1; p < .05), and allowed RRI to return to baseline (p < .05). RRI dips index was an independent predictor of sleep-disordered breathing (SDB) when non-apneic REs were accounted for in symptomatic patients (p < .05). Conclusions: Non-apneic REs without cortical arousal or desaturation are associated with significant respiratory and heart rate changes. Optimal CPAP and the reduction of resistive load are associated with the normalization of heart rate indicating potential clinical benefit.
[Mh] Termos MeSH primário: Síndromes da Apneia do Sono/fisiopatologia
Sono/fisiologia
[Mh] Termos MeSH secundário: Adulto
Resistência das Vias Respiratórias/fisiologia
Pressão Positiva Contínua nas Vias Aéreas
Eletrocardiografia
Feminino
Frequência Cardíaca/fisiologia
Seres Humanos
Masculino
Meia-Idade
Polissonografia
Respiração
Síndromes da Apneia do Sono/diagnóstico
Síndromes da Apneia do Sono/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170402
[St] Status:MEDLINE
[do] DOI:10.1093/sleep/zsw024


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[PMID]:28360111
[Au] Autor:Larcombe AN; Janka MA; Mullins BJ; Berry LJ; Bredin A; Franklin PJ
[Ad] Endereço:Telethon Kids Institute, University of Western Australia, Subiaco, Western Australia, Australia; alexander.larcombe@telethonkids.org.au.
[Ti] Título:The effects of electronic cigarette aerosol exposure on inflammation and lung function in mice.
[So] Source:Am J Physiol Lung Cell Mol Physiol;313(1):L67-L79, 2017 Jul 01.
[Is] ISSN:1522-1504
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Electronic cigarette usage is increasing worldwide, yet there is a paucity of information on the respiratory health effects of electronic cigarette aerosol exposure. This study aimed to assess whether exposure to electronic cigarette (e-cigarette) aerosol would alter lung function and pulmonary inflammation in mice and to compare the severity of any alterations with mice exposed to mainstream tobacco smoke. Female BALB/c mice were exposed for 8 wk to tobacco smoke, medical air (control), or one of four different types of e-cigarette aerosol. E-cigarette aerosols varied depending on nicotine content (0 or 12 mg/ml) and the main excipient (propylene glycol or glycerin). Twenty-four hours after the final exposure, we measured pulmonary inflammation, lung volume, lung mechanics, and responsiveness to methacholine. Mice exposed to tobacco cigarette smoke had increased pulmonary inflammation and responsiveness to methacholine compared with air controls. Mice exposed to e-cigarette aerosol did not have increased inflammation but did display decrements in parenchymal lung function at both functional residual capacity and high transrespiratory pressures. Mice exposed to glycerin-based e-cigarette aerosols were also hyperresponsive to methacholine regardless of the presence or absence of nicotine. This study shows, for the first time, that exposure to e-cigarette aerosol during adolescence and early adulthood is not harmless to the lungs and can result in significant impairments in lung function.
[Mh] Termos MeSH primário: Aerossóis/efeitos adversos
Sistemas Eletrônicos de Liberação de Nicotina/efeitos adversos
Inflamação/patologia
Inflamação/fisiopatologia
Pulmão/patologia
Pulmão/fisiopatologia
[Mh] Termos MeSH secundário: Resistência das Vias Respiratórias/efeitos dos fármacos
Animais
Peso Corporal/efeitos dos fármacos
Elasticidade
Feminino
Capacidade Residual Funcional/efeitos dos fármacos
Cromatografia Gasosa-Espectrometria de Massas
Mediadores da Inflamação/metabolismo
Cloreto de Metacolina/farmacologia
Camundongos Endogâmicos BALB C
Tamanho do Órgão
Pletismografia
Hipersensibilidade Respiratória/complicações
Hipersensibilidade Respiratória/patologia
Hipersensibilidade Respiratória/fisiopatologia
Fumar/efeitos adversos
Tórax/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aerosols); 0 (Inflammation Mediators); 0W5ETF9M2K (Methacholine Chloride)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE
[do] DOI:10.1152/ajplung.00203.2016


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[PMID]:28352168
[Au] Autor:Tajti G; Gesztelyi R; Pak K; Papp C; Keki S; Szilasi ME; Mikaczo A; Fodor A; Szilasi M; Zsuga J
[Ad] Endereço:Department of Health Systems Management and Quality Management for Health Care, Faculty of Public Health; Department of Pulmonology, Faculty of Medicine.
[Ti] Título:Positive correlation of airway resistance and serum asymmetric dimethylarginine level in COPD patients with systemic markers of low-grade inflammation.
[So] Source:Int J Chron Obstruct Pulmon Dis;12:873-884, 2017.
[Is] ISSN:1178-2005
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:The major feature of COPD is a progressive airflow limitation caused by chronic airway inflammation and consequent airway remodeling. Modified arginase and nitric oxide synthase (NOS) pathways are presumed to contribute to the inflammation and fibrosis. Asymmetric dimethylarginine (ADMA) may shunt L-arginine from the NOS pathway to the arginase one by uncoupling and competitive inhibition of NOS and by enhancing arginase activity. To attest the interplay of these pathways, the relationship between ADMA and airflow limitation, described by airway resistance (R ), was investigated in a cohort of COPD patients. Every COPD patient willing to give consent to participate (n=74) was included. Case history, laboratory parameters, serum arginine and ADMA, pulmonary function (whole-body plethysmography), and disease-specific quality of life (St George's Respiratory Questionnaire) were determined. Multiple linear regression was used to identify independent determinants of R . The final multiple model was stratified based on symptom control. The log R showed significant positive correlation with log ADMA in the whole sample (Pearson's correlation coefficient: 0.25, =0.03). This association remained significant after adjusting for confounders in the whole data set ( : 0.42; confidence interval [CI]: 0.06, 0.77; =0.022) and in the worse-controlled stratum ( : 0.84; CI: 0.25, 1.43; =0.007). Percent predicted value of forced expiratory flow between 25% and 75% of forced vital capacity showed that significant negative, elevated C-reactive protein exhibited significant positive relationship with R in the final model. Positive correlation of R with ADMA in COPD patients showing evidence of a systemic low-grade inflammation implies that ADMA contributes to the progression of COPD, probably by shunting L-arginine from the NOS pathway to the arginase one.
[Mh] Termos MeSH primário: Resistência das Vias Respiratórias
Arginina/análogos & derivados
Proteína C-Reativa/análise
Mediadores da Inflamação/sangue
Pulmão/fisiopatologia
Doença Pulmonar Obstrutiva Crônica/sangue
[Mh] Termos MeSH secundário: Idoso
Resistência das Vias Respiratórias/efeitos dos fármacos
Arginina/sangue
Biomarcadores/sangue
Broncodilatadores/uso terapêutico
Distribuição de Qui-Quadrado
Estudos Transversais
Progressão da Doença
Feminino
Seres Humanos
Modelos Lineares
Pulmão/efeitos dos fármacos
Masculino
Fluxo Máximo Médio Expiratório
Meia-Idade
Pletismografia Total
Doença Pulmonar Obstrutiva Crônica/diagnóstico
Doença Pulmonar Obstrutiva Crônica/tratamento farmacológico
Doença Pulmonar Obstrutiva Crônica/fisiopatologia
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Bronchodilator Agents); 0 (Inflammation Mediators); 63CV1GEK3Y (N,N-dimethylarginine); 9007-41-4 (C-Reactive Protein); 94ZLA3W45F (Arginine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170330
[St] Status:MEDLINE
[do] DOI:10.2147/COPD.S127373



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