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[PMID]:29338164
[Au] Autor:Novkovic D; Petrovic M; Zivkovic V; Baletic N
[Ti] Título:The relation between nonspecific hyperreactivity of the airways and atopic constitution in asthmatics.
[So] Source:Vojnosanit Pregl;73(11):1056-9, 2016 Nov.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Background/Aim: Hyperreactivity of the airways caused by inflammation in asthmatics is the most important pathophysiological change. It represents a suitable ground that in the presence of risk factors and the drivers of asthma, asthmatic attack occurs. Atopic constitution is one of the most important risk factors for the development and expression of asthma. The aim of our study was to investigate the relationship between nonspecific airway hyperreactivity and atopic constituton in asthmatics. Methods: This retrospective analysis was conducted considering the results of nonspecific bronchoprovocative test with histamine, skin tests to inhalant allergens and total IgE levels in the serum of asthmatic patients with controlled bronchial asthma. The sample consisted of 162 asthmatics examined during one-year period. Results: The examinees were male asthmatic patients, aged between 18 and 30 years. We found that the examinees with a pronounced non-specific hyperreactivity had more significant skin reaction to inhaled allergens and higher levels of total IgE in serum. Conclusion: The results of our study show that the intensity of airway hyperresponsiveness to histamine in asthmatics is directly related to atopic constitution.
[Mh] Termos MeSH primário: Asma/fisiopatologia
Hiper-Reatividade Brônquica/fisiopatologia
Broncoconstrição
Dermatite Atópica/imunologia
Pulmão/fisiopatologia
[Mh] Termos MeSH secundário: Administração por Inalação
Adolescente
Adulto
Asma/diagnóstico
Asma/imunologia
Biomarcadores/sangue
Hiper-Reatividade Brônquica/diagnóstico
Hiper-Reatividade Brônquica/imunologia
Testes de Provocação Brônquica
Dermatite Atópica/sangue
Dermatite Atópica/diagnóstico
Histamina/administração & dosagem
Seres Humanos
Imunoglobulina E/sangue
Pulmão/imunologia
Masculino
Estudos Retrospectivos
Fatores de Risco
Testes Cutâneos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 37341-29-0 (Immunoglobulin E); 820484N8I3 (Histamine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.2298/VSP141029120N


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[PMID]:29211208
[Au] Autor:Meneghini AC; Paulino ACB; Pereira LP; Vianna EO
[Ad] Endereço:MSc. Doctoral Student, Department of Social Medicine, Faculdade de Medicina de Ribeirão Preto (FMRP), Universidade de São Paulo (USP), Ribeirão Preto (SP), Brazil.
[Ti] Título:Accuracy of spirometry for detection of asthma: a cross-sectional study.
[So] Source:Sao Paulo Med J;135(5):428-433, 2017 Sep-Oct.
[Is] ISSN:1806-9460
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Asthma is a chronic inflammatory disease with airway hyperresponsiveness. Spirometry is the most commonly used test among asthmatic patients. Another functional test used for diagnosing asthma is the bronchial challenge test. The aim of this study was to analyze the accuracy of spirometry for detecting asthma in the general population. DESIGN AND SETTING: Cross-sectional study with data analysis to evaluate the accuracy of spirometry through calculating sensitivity, specificity and predictive values and through the kappa agreement test. METHODS: Subjects who constituted a birth cohort were enrolled at the age of 23 to 25 years. Spirometric abnormality was defined as reduced forced expiratory volume in one second, i.e. lower than 80% of the predicted value. Measurement of bronchial responsiveness was performed by means of the bronchial challenge test with methacholine. The gold-standard diagnosis of asthma was defined as the presence of bronchial hyperresponsiveness in association with respiratory symptoms. RESULTS: Asthma was detected in 200 subjects (10.4%) out of the sample of 1922 individuals. Spirometric abnormality was detected in 208 subjects (10.9%) of the sample. The specificity of spirometric abnormality for detecting asthma was 90%, sensitivity was 23%, positive predictive value was 22%, and negative predictive value was 91%. The kappa test revealed weak agreement of 0.13 (95% confidence interval, CI: 0.07-0.19) between spirometry and the diagnosis of asthma. CONCLUSION: Spirometry, as a single test, has limitations for detecting asthma in the general population.
[Mh] Termos MeSH primário: Asma/diagnóstico
Espirometria
[Mh] Termos MeSH secundário: Adolescente
Asma/epidemiologia
Brasil/epidemiologia
Testes de Provocação Brônquica
Broncoconstritores
Criança
Pré-Escolar
Estudos Transversais
Feminino
Seres Humanos
Lactente
Masculino
Cloreto de Metacolina
Valor Preditivo dos Testes
Sensibilidade e Especificidade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bronchoconstrictor Agents); 0W5ETF9M2K (Methacholine Chloride)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


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[PMID]:28787742
[Au] Autor:Singh U; Bernstein JA; Lorentz H; Sadoway T; Nelson V; Patel P; Salapatek AM
[Ad] Endereço:University of Cincinnati Medical Center, Cincinnati, OH, USA.
[Ti] Título:A Pilot Study Investigating Clinical Responses and Biological Pathways of Azelastine/Fluticasone in Nonallergic Vasomotor Rhinitis before and after Cold Dry Air Provocation.
[So] Source:Int Arch Allergy Immunol;173(3):153-164, 2017.
[Is] ISSN:1423-0097
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Nonallergic vasomotor rhinitis (NAVMR) has been considered a diagnosis by exclusion due to unknown mechanisms or lack of diagnostic biomarkers. METHODS: To determine clinical responses and biological pathways in NAVMR subjects challenged to cold dry air (CDA) in an environmental exposure chamber (EEC) pre- and posttreatment with azelastine/fluticasone (AzeFlu), 30 NAVMR subjects, prescreened for CDA-induced symptoms (approx. 14°C, <15% relative humidity, ×1 h) were randomized to treatment with AzeFlu (n = 20) or placebo (n = 10) for 2 weeks. Total nasal symptoms scores, minimum cross-sectional area, cough, and conjunctival redness were recorded at visit 1 (pretreatment) and visit 2 (posttreatment) before, during, and after CDA challenge. At both visits, nasal lavage fluid (NLF) and nasal scrapings (NS) were collected pre- and post-CDA challenge. Substance P, neurokinin-A, and calcitonin gene-related peptide concentrations in NLF were analyzed pre- and postchallenge at each visit. Their relationship with CDA-induced symptoms was determined by statistical analysis. MicroRNA sequencing from NS determined differentially expressed miRNA between the treatment groups post-CDA challenge at each visit. RESULTS: The minimum cross-sectional area (p < 0.05), cough count (p < 0.05), and substance P (p < 0.01) improved posttreatment with AzeFlu versus placebo. Gene targets for differentially expressed miRNAs at visit 1 were enriched for biological pathways regulating epithelial ciliogenesis and cell integrity that were modified in the AzeFlu-treated group versus placebo posttreatment. CONCLUSIONS: This study demonstrated the feasibility of an EEC model to investigate CDA-induced clinical responses and pathobiology in NAVMR subjects pre- and posttreatment with AzeFlu. NAVMR disease mechanisms for other nonallergic triggers can be investigated similarly.
[Mh] Termos MeSH primário: Anti-Inflamatórios/uso terapêutico
Testes de Provocação Brônquica
Tosse/tratamento farmacológico
Fluticasona/uso terapêutico
Ftalazinas/uso terapêutico
Rinite Vasomotora/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Ar
Temperatura Baixa
Tosse/metabolismo
Feminino
Seres Humanos
Masculino
MicroRNAs/metabolismo
Meia-Idade
Mucosa Nasal/metabolismo
Projetos Piloto
Rinite Vasomotora/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (MicroRNAs); 0 (Phthalazines); CUT2W21N7U (Fluticasone); ZQI909440X (azelastine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170809
[St] Status:MEDLINE
[do] DOI:10.1159/000478698


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[PMID]:28583260
[Au] Autor:Galant SP; Komarow HD; Shin HW; Siddiqui S; Lipworth BJ
[Ad] Endereço:Children's Hospital of Orange County, Orange, California. Electronic address: sgalant@choc.org.
[Ti] Título:The case for impulse oscillometry in the management of asthma in children and adults.
[So] Source:Ann Allergy Asthma Immunol;118(6):664-671, 2017 Jun.
[Is] ISSN:1534-4436
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To provide a clinical rationale for including impulse oscillometry (IOS) as a part of standard office-based asthma assessment. DATA SOURCES: PubMed and Google search, limited to English language and human disease, with the keywords IOS and asthma. STUDY SELECTIONS: Articles included in this review were based on the expert opinion and previous publications by the authors. RESULTS: In children, IOS was more useful than spirometry in identifying asthma and uncontrolled asthma and predicting loss of control and exacerbations. IOS predicts young children at risk for loss of lung function with age and the potential for early intervention to prevent further sequelae. In adults, peripheral airway impairment detected by IOS or spirometry (ie, forced expiratory flow between 25% and 75%) commonly occurs across severity, and each measure may be complementary in predicting loss of control even with normal forced expiratory volume in 1 second. Extrafine inhaled corticosteroids with or without long-acting ß-agonists proved superior to standard particle aerosols in improving IOS-detected peripheral airway obstruction. Our data also suggest that currently available commercial reference values for lung resistance at 5 Hz and lung reactance at 5 Hz are applicable across diverse populations, but further studies are needed. CONCLUSION: The findings of this review suggest that IOS can add value to traditional clinical and spirometric assessment and thus improve management of asthma in children and adults, as well as have the potential to detect early dysfunction of the peripheral airways, which may result in better outcomes.
[Mh] Termos MeSH primário: Asma/diagnóstico
Oscilometria/métodos
[Mh] Termos MeSH secundário: Corticosteroides/uso terapêutico
Adulto
Asma/tratamento farmacológico
Asma/fisiopatologia
Testes de Provocação Brônquica
Criança
Seres Humanos
Valores de Referência
Espirometria
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170607
[St] Status:MEDLINE


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[PMID]:28561329
[Au] Autor:Fux M; von Garnier C
[Ad] Endereço:University Institute of Clinicla Chemistry, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
[Ti] Título:Sputum basophils and asthma diagnosis: dawn of a new era?
[So] Source:Allergy;72(10):1437-1439, 2017 10.
[Is] ISSN:1398-9995
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Mh] Termos MeSH primário: Basófilos
Escarro
[Mh] Termos MeSH secundário: Asma
Testes de Provocação Brônquica
Seres Humanos
Contagem de Leucócitos
[Pt] Tipo de publicação:EDITORIAL; COMMENT
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE
[do] DOI:10.1111/all.13214


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Registro de Ensaios Clínicos
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[PMID]:28514613
[Au] Autor:Cahill KN; Katz HR; Cui J; Lai J; Kazani S; Crosby-Thompson A; Garofalo D; Castro M; Jarjour N; DiMango E; Erzurum S; Trevor JL; Shenoy K; Chinchilli VM; Wechsler ME; Laidlaw TM; Boyce JA; Israel E
[Ad] Endereço:From Brigham and Women's Hospital, Harvard Medical School, Boston (K.N.C., H.R.K., J.C., J.L., A.C.-T., D.G., T.M.L., J.A.B., E.I.), and Novartis Institutes for BioMedical Research, Cambridge (S.K.) - both in Massachusetts; Washington University, St. Louis (M.C.); University of Wisconsin, Madison (N
[Ti] Título:KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma.
[So] Source:N Engl J Med;376(20):1911-1920, 2017 05 18.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Mast cells are present in the airways of patients who have severe asthma despite glucocorticoid treatment; these cells are associated with disease characteristics including poor quality of life and inadequate asthma control. Stem cell factor and its receptor, KIT, are central to mast-cell homeostasis. We conducted a proof-of-principle trial to evaluate the effect of imatinib, a KIT inhibitor, on airway hyperresponsiveness, a physiological marker of severe asthma, as well as on airway mast-cell numbers and activation in patients with severe asthma. METHODS: We conducted a randomized, double-blind, placebo-controlled, 24-week trial of imatinib in patients with poorly controlled severe asthma who had airway hyperresponsiveness despite receiving maximal medical therapy. The primary end point was the change in airway hyperresponsiveness, measured as the concentration of methacholine required to decrease the forced expiratory volume in 1 second by 20% (PC ). Patients also underwent bronchoscopy. RESULTS: Among the 62 patients who underwent randomization, imatinib treatment reduced airway hyperresponsiveness to a greater extent than did placebo. At 6 months, the methacholine PC increased by a mean (±SD) of 1.73±0.60 doubling doses in the imatinib group, as compared with 1.07±0.60 doubling doses in the placebo group (P=0.048). Imatinib also reduced levels of serum tryptase, a marker of mast-cell activation, to a greater extent than did placebo (decrease of 2.02±2.32 vs. 0.56±1.39 ng per milliliter, P=0.02). Airway mast-cell counts declined in both groups. Muscle cramps and hypophosphatemia were more common in the imatinib group than in the placebo group. CONCLUSIONS: In patients with severe asthma, imatinib decreased airway hyperresponsiveness, mast-cell counts, and tryptase release. These results suggest that KIT-dependent processes and mast cells contribute to the pathobiologic basis of severe asthma. (Funded by the National Institutes of Health and others; ClinicalTrials.gov number, NCT01097694 .).
[Mh] Termos MeSH primário: Asma/tratamento farmacológico
Mesilato de Imatinib/uso terapêutico
Mastócitos/metabolismo
Inibidores de Proteínas Quinases/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Asma/imunologia
Asma/fisiopatologia
Hiper-Reatividade Brônquica/tratamento farmacológico
Testes de Provocação Brônquica
Contagem de Células
Método Duplo-Cego
Feminino
Volume Expiratório Forçado/efeitos dos fármacos
Seres Humanos
Mesilato de Imatinib/efeitos adversos
Masculino
Cloreto de Metacolina
Meia-Idade
Inibidores de Proteínas Quinases/efeitos adversos
Qualidade de Vida
Triptases/sangue
Triptases/secreção
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Protein Kinase Inhibitors); 0W5ETF9M2K (Methacholine Chloride); 8A1O1M485B (Imatinib Mesylate); EC 3.4.21.59 (Tryptases)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171118
[Lr] Data última revisão:
171118
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170518
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMoa1613125


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[PMID]:28407251
[Au] Autor:Mangin D; Bequignon E; Zerah-Lancner F; Isabey D; Louis B; Adnot S; Papon JF; Coste A; Boyer L; Devars du Mayne M
[Ad] Endereço:Department of Otorhinolaryngology and Facial Cervical Surgery, Intercommunal Hospital Center of Créteil, Créteil, France.
[Ti] Título:Investigating hyperventilation syndrome in patients suffering from empty nose syndrome.
[So] Source:Laryngoscope;127(9):1983-1988, 2017 Sep.
[Is] ISSN:1531-4995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES/HYPOTHESIS: Patients with empty nose syndrome (ENS) following turbinate surgery often complain about breathing difficulties. We set out to determine if dyspnea in patients with ENS was associated with hyperventilation syndrome (HVS). We hypothesized that lower airway symptoms in ENS could be explained by HVS. STUDY DESIGN: Observational prospective study. METHODS: All consecutive patients referred to our center for ENS over 1 year were invited to participate. Patients completed the Nijmegen score and underwent a hyperventilation provocation test (HVPT) and arterial blood gas and cardiopulmonary tests. HVS was defined by a delayed return of the end-tidal partial pressure of carbon dioxide in the expired gas to baseline during HVPT. Patients with HVS were asked to complete the Sinonasal Outcome Test (SNOT)-16 questionnaire before and after a specific eight-session respiratory rehabilitation program. RESULTS: Twenty-two of the 29 patients referred for ENS during the study period were eligible for inclusion and underwent a complete workup. HVS was diagnosed in 17 of these patients (77.3%). In the five patients who completed the SNOT-16, the score was significantly lower after rehabilitation. CONCLUSIONS: This study suggests that HVS is frequent in patients with ENS, and that symptoms can be improved by respiratory rehabilitation. Pathophysiological links between ENS and HVS deserve to be further explored. LEVEL OF EVIDENCE: 2b Laryngoscope, 127:1983-1988, 2017.
[Mh] Termos MeSH primário: Hiperventilação/fisiopatologia
Obstrução Nasal/fisiopatologia
Procedimentos Cirúrgicos Nasais/efeitos adversos
Complicações Pós-Operatórias/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Monitorização Transcutânea dos Gases Sanguíneos
Testes de Provocação Brônquica
Dispneia/etiologia
Dispneia/fisiopatologia
Dispneia/reabilitação
Feminino
Seres Humanos
Hiperventilação/etiologia
Masculino
Meia-Idade
Obstrução Nasal/etiologia
Obstrução Nasal/reabilitação
Procedimentos Cirúrgicos Nasais/reabilitação
Complicações Pós-Operatórias/etiologia
Complicações Pós-Operatórias/reabilitação
Estudos Prospectivos
Inquéritos e Questionários
Síndrome
Volume de Ventilação Pulmonar
Resultado do Tratamento
Conchas Nasais/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE
[do] DOI:10.1002/lary.26599


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[PMID]:28300726
[Au] Autor:Foy BH; Kay D
[Ad] Endereço:Department of Computer Science, University of Oxford, Oxford, Oxfordshire, United Kingdom. Electronic address: brody.foy@new.ox.ac.uk.
[Ti] Título:A computational comparison of the multiple-breath washout and forced oscillation technique as markers of bronchoconstriction.
[So] Source:Respir Physiol Neurobiol;240:61-69, 2017 Jun.
[Is] ISSN:1878-1519
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Many types of lung disease lead to constriction of airways within the conducting zone, causing increases in airway resistance and ventilation heterogeneity (VH). The multiple-breath washout (MBW) and forced oscillation technique (FOT) are two clinical measures of small airway bronchoconstriction. Within this study computational modelling of the MBW and FOT was applied to the analysis of thousands of bronchoconstriction scenarios in the conducting zone of the lungs. The simulations show that MBW indices primarily respond to the severity of constriction, while FOT indices may be able to distinguish between constrictions at differing airway depths. Following this, we show the potential utility in the joint interpretation of indices from the two tests, providing motivations for future clinical investigations.
[Mh] Termos MeSH primário: Resistência das Vias Respiratórias/fisiologia
Broncoconstrição/fisiologia
Simulação por Computador
Volume Expiratório Forçado/fisiologia
Modelos Biológicos
[Mh] Termos MeSH secundário: Testes de Provocação Brônquica
Seres Humanos
Ventilação Pulmonar/fisiologia
Testes de Função Respiratória
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170426
[Lr] Data última revisão:
170426
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE


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[PMID]:28214133
[Au] Autor:Mediano O; Casitas R; Villasante C; Martínez-Cerón E; Galera R; Zamarrón E; García-Río F
[Ad] Endereço:Respiratory Diseases Section, Guadalajara University Hospital, Guadalajara, Spain.
[Ti] Título:Dynamic hyperinflation in patients with asthma and exercise-induced bronchoconstriction.
[So] Source:Ann Allergy Asthma Immunol;118(4):427-432, 2017 Apr.
[Is] ISSN:1534-4436
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Little is known about the behavior of operative lung volumes during exercise in patients with asthma and exercise-induced bronchoconstriction (EIB). OBJECTIVE: To compare the presence of dynamic hyperinflation (DH) in patients with mild asthma with and without EIB and in healthy individuals and to relate the changes in end-expiratory lung volume (EELV) with postexercise airflow reduction. METHODS: A total of 122 consecutive stable patients (>12 years of age) with mild asthma and 38 controls were studied. Baseline lung volumes were measured, and all patients performed an exercise bronchial challenge. At each minute of exercise, EELV and end-inspiratory lung volume (EILV) were estimated from inspiratory capacity measurements to align the tidal breathing flow-volume loops to within the maximal expiratory curve. RESULTS: DH was more frequent in patients with asthma and EIB (76%) than in patients with asthma but without EIB (11%) or controls (18%). The EELV increased in patients with asthma and EIB and decreased in patients with asthma without EIB and controls during exercise. In the patients with asthma, the decrease in forced expiratory volume in 1 second after the exercise challenge correlated with age (r = -0.179, P = .05), baseline forced vital capacity (r = 0.255, P = .005), EELV increase (r = 0.447, P < .001), and EILV increase (r = 0.246, P = .007). Age, baseline forced vital capacity, and magnitude of DH were retained as independent predictors of EIB intensity. CONCLUSION: In patients with asthma and EIB, the development of DH is very frequent and related to the intensity of postexercise bronchoconstriction. This finding could implicate DH in the development of EIB.
[Mh] Termos MeSH primário: Asma Induzida por Exercício/diagnóstico
Asma Induzida por Exercício/fisiopatologia
Broncoconstrição
[Mh] Termos MeSH secundário: Adolescente
Adulto
Testes de Provocação Brônquica
Estudos de Casos e Controles
Criança
Feminino
Volume Expiratório Forçado
Seres Humanos
Incidência
Masculino
Testes de Função Respiratória
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170219
[St] Status:MEDLINE


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[PMID]:28211350
[Au] Autor:Jara-Gutiérrez P; Zafra MP; Sanz V; Del Pozo V; Fernandez-Nieto M
[Ad] Endereço:Allergy Department Fundación Jiménez Díaz, Madrid, Spain.
[Ti] Título:Asthma Due to Swiss Chard: Identification of a New Allergen.
[So] Source:J Investig Allergol Clin Immunol;27(1):67-68, 2017.
[Is] ISSN:1018-9068
[Cp] País de publicação:Spain
[La] Idioma:eng
[Mh] Termos MeSH primário: Alérgenos/efeitos adversos
Asma/induzido quimicamente
Beta vulgaris/efeitos adversos
Proteínas de Ligação à Clorofila/efeitos adversos
Hipersensibilidade Alimentar/etiologia
Folhas de Planta/efeitos adversos
[Mh] Termos MeSH secundário: Corticosteroides/administração & dosagem
Alérgenos/imunologia
Asma/diagnóstico
Asma/tratamento farmacológico
Asma/imunologia
Beta vulgaris/imunologia
Biomarcadores/sangue
Testes de Provocação Brônquica
Proteínas de Ligação à Clorofila/imunologia
Feminino
Hipersensibilidade Alimentar/diagnóstico
Hipersensibilidade Alimentar/tratamento farmacológico
Hipersensibilidade Alimentar/imunologia
Seres Humanos
Imunoglobulina E/sangue
Testes Intradérmicos
Meia-Idade
Folhas de Planta/imunologia
Indução de Remissão
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Allergens); 0 (Biomarkers); 0 (Chlorophyll Binding Proteins); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE
[do] DOI:10.18176/jiaci.0120



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