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  1 / 9279 MEDLINE  
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[PMID]:29388831
[Au] Autor:Radder JE; Shapiro SD
[Ad] Endereço:1 University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania.
[Ti] Título:Reply to: Quantitative Histology Seriously Flawed by Lack of Lung Volume Measurement.
[So] Source:Am J Respir Cell Mol Biol;58(2):274-275, 2018 02.
[Is] ISSN:1535-4989
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Fumar Cigarros/efeitos adversos
Medidas de Volume Pulmonar
Pulmão/fisiologia
Fumaça/efeitos adversos
[Mh] Termos MeSH secundário: Animais
Pulmão/anatomia & histologia
Camundongos
[Pt] Tipo de publicação:LETTER
[Nm] Nome de substância:
0 (Smoke)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180202
[St] Status:MEDLINE
[do] DOI:10.1165/rcmb.2017-0394LE


  2 / 9279 MEDLINE  
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[PMID]:29388832
[Au] Autor:Mitzner W; Ochs M
[Ad] Endereço:1 Johns Hopkins Bloomberg School of Public Health Baltimore, Maryland and.
[Ti] Título:Quantitative Histology Seriously Flawed by Lack of Lung Volume Measurement.
[So] Source:Am J Respir Cell Mol Biol;58(2):273-274, 2018 02.
[Is] ISSN:1535-4989
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Fumar Cigarros/efeitos adversos
Medidas de Volume Pulmonar
Pulmão/fisiologia
Fumaça/efeitos adversos
[Mh] Termos MeSH secundário: Animais
Pulmão/anatomia & histologia
Camundongos
[Pt] Tipo de publicação:LETTER
[Nm] Nome de substância:
0 (Smoke)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180202
[St] Status:MEDLINE
[do] DOI:10.1165/rcmb.2017-0380LE


  3 / 9279 MEDLINE  
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[PMID]:28451990
[Au] Autor:Solav D; Meric H; Rubin MB; Pradon D; Lofaso F; Wolf A
[Ad] Endereço:Faculty of Mechanical Engineering, Technion Israel Institute of Technology, 32000, Haifa, Israel. danask@mit.edu.
[Ti] Título:Chest Wall Kinematics Using Triangular Cosserat Point Elements in Healthy and Neuromuscular Subjects.
[So] Source:Ann Biomed Eng;45(8):1963-1973, 2017 08.
[Is] ISSN:1573-9686
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Optoelectronic plethysmography (OEP) is a noninvasive method for assessing lung volume variations and the contributions of different anatomical compartments of the chest wall (CW) through measurements of the motion of markers attached to the CW surface. The present study proposes a new method for analyzing the local CW kinematics from OEP measurements based on the kinematics of triangular Cosserat point elements (TCPEs). 52 reflective markers were placed on the anterior CW to create a mesh of 78 triangles according to an anatomical model. Each triangle was characterized by a TCPE and its kinematics was described using four time-variant scalar TCPE parameters. The total CW volume ([Formula: see text]) and the contributions of its six compartments were also estimated, using the same markers. The method was evaluated using measurements of ten healthy subjects, nine patients with Pompe disease, and ten patients with Duchenne muscular dystrophy (DMD), during spontaneous breathing (SB) and vital capacity maneuvers (VC) in the supine position. TCPE parameters and compartmental volumes were compared with [Formula: see text] by computing the phase angles [Formula: see text] (for SB) and the correlation r (for VC) between them. Analysis of [Formula: see text] and r of the outward translation parameter [Formula: see text] of each TCPE revealed that for healthy subjects it provided similar results to those obtained by compartmental volumes, whereas for the neuromuscular patients the TCPE method was capable of detecting local asynchronous and paradoxical movements also in cases where they were undistinguished by volumes. Therefore, the TCPE approach provides additional information to OEP that may enhance its clinical evaluation capabilities.
[Mh] Termos MeSH primário: Medidas de Volume Pulmonar/métodos
Modelos Biológicos
Doenças Neuromusculares/fisiopatologia
Fotopletismografia/métodos
Mecânica Respiratória
Parede Torácica/fisiopatologia
Volume de Ventilação Pulmonar
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Simulação por Computador
Feminino
Análise de Elementos Finitos
Doença de Depósito de Glicogênio Tipo II
Seres Humanos
Masculino
Meia-Idade
Doenças Neuromusculares/diagnóstico
Valores de Referência
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1007/s10439-017-1840-6


  4 / 9279 MEDLINE  
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[PMID]:27773445
[Au] Autor:Lens E; Gurney-Champion OJ; Tekelenburg DR; van Kesteren Z; Parkes MJ; van Tienhoven G; Nederveen AJ; van der Horst A; Bel A
[Ad] Endereço:Department of Radiation Oncology, Academic Medical Center/University of Amsterdam, The Netherlands. Electronic address: e.lens@amc.uva.nl.
[Ti] Título:Abdominal organ motion during inhalation and exhalation breath-holds: pancreatic motion at different lung volumes compared.
[So] Source:Radiother Oncol;121(2):268-275, 2016 11.
[Is] ISSN:1879-0887
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Contrary to what is commonly assumed, organs continue to move during breath-holding. We investigated the influence of lung volume on motion magnitude during breath-holding and changes in velocity over the duration of breath-holding. MATERIALS AND METHODS: Sixteen healthy subjects performed 60-second inhalation breath-holds in room-air, with lung volumes of ∼100% and ∼70% of the inspiratory capacity, and exhalation breath-holds, with lung volumes of ∼30% and ∼0% of the inspiratory capacity. During breath-holding, we obtained dynamic single-slice magnetic-resonance images with a time-resolution of 0.6s. We used 2-dimensional image correlation to obtain the diaphragmatic and pancreatic velocity and displacement during breath-holding. RESULTS: Organ velocity was largest in the inferior-superior direction and was greatest during the first 10s of breath-holding, with diaphragm velocities of 0.41mm/s, 0.29mm/s, 0.16mm/s and 0.15mm/s during BH , BH , BH and BH , respectively. Organ motion magnitudes were larger during inhalation breath-holds (diaphragm moved 9.8 and 9.0mm during BH and BH , respectively) than during exhalation breath-holds (5.6 and 4.3mm during BH and BH , respectively). CONCLUSION: Using exhalation breath-holds rather than inhalation breath-holds and delaying irradiation until after the first 10s of breath-holding may be advantageous for irradiation of abdominal tumors.
[Mh] Termos MeSH primário: Suspensão da Respiração
Inalação/fisiologia
Pulmão/fisiologia
Movimento/fisiologia
Pâncreas/fisiologia
[Mh] Termos MeSH secundário: Adulto
Diafragma/diagnóstico por imagem
Diafragma/fisiologia
Expiração/fisiologia
Feminino
Seres Humanos
Pulmão/diagnóstico por imagem
Medidas de Volume Pulmonar/métodos
Imagem por Ressonância Magnética/métodos
Masculino
Pâncreas/diagnóstico por imagem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  5 / 9279 MEDLINE  
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[PMID]:28796825
[Au] Autor:Shin JM; Kim TH; Haam S; Han K; Byun MK; Chang YS; Kim HJ; Park CH
[Ad] Endereço:Department of Radiology and the Research Institute of Radiological Science, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
[Ti] Título:The repeatability of computed tomography lung volume measurements: Comparisons in healthy subjects, patients with obstructive lung disease, and patients with restrictive lung disease.
[So] Source:PLoS One;12(8):e0182849, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this study, we examined the repeatability of computed tomography (CT) lung volume measurements in healthy individuals and patients with obstructive and restrictive lung diseases. To do this, we retrospectively enrolled 200 healthy individuals (group 1), 100 patients with obstructive lung disease (group 2), and 100 patients with restrictive lung disease (group 3) who underwent two consecutive chest CT scans within a 1-year period. The CT lung volume was measured using a threshold-based, three-dimensional auto-segmentation technique at a default range from -200 to -1024 HU. The within-subject standard deviation, repeatability coefficient, within-subject coefficient variability, and intraclass correlation coefficient were evaluated. No significant differences were identified between the two consecutive CT lung volume measurements in any of the groups (p> 0.05). The within-subject standard deviations for groups 1, 2, and 3 were 441.1, 387.0, and 288.6, respectively, while the repeatability coefficients were 1222.6, 1072.6, and 800.1, respectively. The within-subject coefficient variabilities for groups 1, 2, and 3 were 0.097, 0.083, and 0.090, respectively, while the intraclass correlation coefficients were 0.818, 0.881, and 0.910, respectively. The two CT lung volume measurements showed excellent agreement in healthy individuals and patients with obstructive or restrictive lung disease. However, the repeatability was lower in healthy individuals than it was in patients with lung diseases.
[Mh] Termos MeSH primário: Pneumopatias/diagnóstico por imagem
Pulmão/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Voluntários Saudáveis
Seres Humanos
Pneumopatias Obstrutivas/diagnóstico por imagem
Medidas de Volume Pulmonar
Masculino
Meia-Idade
Reprodutibilidade dos Testes
Estudos Retrospectivos
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170811
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182849


  6 / 9279 MEDLINE  
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[PMID]:28759656
[Au] Autor:Montesantos S; Katz I; Venegas J; Pichelin M; Caillibotte G
[Ad] Endereço:Medical R&D, Air Liquide Santé International, Paris Saclay, France.
[Ti] Título:The effect of disease and respiration on airway shape in patients with moderate persistent asthma.
[So] Source:PLoS One;12(7):e0182052, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Computational models of gas transport and aerosol deposition frequently utilize idealized models of bronchial tree structure, where airways are considered a network of bifurcating cylinders. However, changes in the shape of the lung during respiration affect the geometry of the airways, especially in disease conditions. In this study, the internal airway geometry was examined, concentrating on comparisons between mean lung volume (MLV) and total lung capacity (TLC). A set of High Resolution CT images were acquired during breath hold on a group of moderate persistent asthmatics at MLV and TLC after challenge with a broncho-constrictor (methacholine) and the airway trees were segmented and measured. The airway hydraulic diameter (Dh) was calculated through the use of average lumen area (Ai) and average internal perimeter (Pi) at both lung volumes and was found to be systematically higher at TLC by 13.5±9% on average, with the lower lobes displaying higher percent change in comparison to the lower lobes. The average internal diameter (Din) was evaluated to be 12.4±6.8% (MLV) and 10.8±6.3% (TLC) lower than the Dh, for all the examined bronchi, a result displaying statistical significance. Finally, the airway distensibility per bronchial segment and per generation was calculated to have an average value of 0.45±0.28, exhibiting high variability both between and within lung regions and generations. Mixed constriction/dilation patterns were recorded between the lung volumes, where a number of airways either failed to dilate or even constricted when observed at TLC. We conclude that the Dh is higher than Din, a fact that may have considerable effects on bronchial resistance or airway loss at proximal regions. Differences in caliber changes between lung regions are indicative of asthma-expression variability in the lung. However, airway distensibility at generation 3 seems to predict distensibility more distally.
[Mh] Termos MeSH primário: Asma/diagnóstico por imagem
Pulmão/diagnóstico por imagem
Respiração
[Mh] Termos MeSH secundário: Adolescente
Asma/fisiopatologia
Estudos de Casos e Controles
Feminino
Seres Humanos
Pulmão/fisiologia
Medidas de Volume Pulmonar
Masculino
Tomografia Computadorizada por Raios X
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182052


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[PMID]:28669608
[Au] Autor:Schopper MA; Walkup LL; Tkach JA; Higano NS; Lim FY; Haberman B; Woods JC; Kingma PS
[Ad] Endereço:Section of Neonatology, Perinatal and Pulmonary Biology, The Perinatal Institute, Cincinnati, OH.
[Ti] Título:Evaluation of Neonatal Lung Volume Growth by Pulmonary Magnetic Resonance Imaging in Patients with Congenital Diaphragmatic Hernia.
[So] Source:J Pediatr;188:96-102.e1, 2017 Sep.
[Is] ISSN:1097-6833
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate postnatal lung volume in infants with congenital diaphragmatic hernia (CDH) and determine if a compensatory increase in lung volume occurs during the postnatal period. STUDY DESIGN: Using a novel pulmonary magnetic resonance imaging method for imaging neonatal lungs, the postnatal lung volumes in infants with CDH were determined and compared with prenatal lung volumes obtained via late gestation magnetic resonance imaging. RESULTS: Infants with left-sided CDH (2 mild, 9 moderate, and 1 severe) were evaluated. The total lung volume increased in all infants, with the contralateral lung increasing faster than the ipsilateral lung (mean ± SD: 4.9 ± 3.0 mL/week vs 3.4 ± 2.1 mL/week, P = .005). In contrast to prenatal studies, the volume of lungs of infants with more severe CDH grew faster than the lungs of infants with more mild CDH (Spearman's ρ=-0.086, P = .01). Although the contralateral lung volume grew faster in both mild and moderate groups, the majority of total lung volume growth in moderate CDH came from increased volume of the ipsilateral lung (42% of total lung volume increase in the moderate group vs 32% of total lung volume increase in the mild group, P = .09). Analysis of multiple clinical variables suggests that increased weight gain was associated with increased compensatory ipsilateral lung volume growth (ρ = 0.57, P = .05). CONCLUSIONS: These results suggest a potential for postnatal catch-up growth in infants with pulmonary hypoplasia and suggest that weight gain may increase the volume growth of the more severely affected lung.
[Mh] Termos MeSH primário: Hérnias Diafragmáticas Congênitas/fisiopatologia
Pulmão/fisiopatologia
Imagem por Ressonância Magnética/métodos
[Mh] Termos MeSH secundário: Feminino
Idade Gestacional
Seres Humanos
Recém-Nascido
Pulmão/crescimento & desenvolvimento
Medidas de Volume Pulmonar/métodos
Masculino
Gravidez
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170704
[St] Status:MEDLINE


  8 / 9279 MEDLINE  
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[PMID]:28632593
[Au] Autor:Johnston CE; Tran DP; McClung A
[Ad] Endereço:1Texas Scottish Rite Hospital, Dallas, Texas.
[Ti] Título:Functional and Radiographic Outcomes Following Growth-Sparing Management of Early-Onset Scoliosis.
[So] Source:J Bone Joint Surg Am;99(12):1036-1042, 2017 Jun 21.
[Is] ISSN:1535-1386
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In this study, we sought to evaluate radiographic, functional, and quality-of-life outcomes of patients who have completed growth-sparing management of early-onset scoliosis. METHODS: This prospective study involved patients with early-onset scoliosis who underwent growth-sparing treatment and either "final" fusion or observation for ≥2 years since the last lengthening procedure. Demographics, radiographic parameters, pulmonary function test (PFT) values, and scores of patient-reported assessments (Early-Onset Scoliosis Questionnaire [EOSQ] and Scoliosis Research Society [SRS]-30) were obtained. At the most recent follow-up, patients performed 2 additional functional outcome tests: step-activity monitoring and a treadmill exercise-tolerance test. RESULTS: Twelve patients were evaluated as "graduates" of growth-sparing management of early-onset scoliosis (mean of 37 months since the most recent surgery). The major scoliosis curve measurement averaged 88° before treatment and 47° at the most recent follow-up. T1-S1 height increased from a mean of 22.3 cm to 34.7 cm and T1-T12 height, from 13.3 to 22.3 cm. At the most recent follow-up, the mean forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) as a percentage of the predicted volume were 52.1% and 55.3%, respectively, and were essentially unchanged from the earliest PFT that patients could perform (FEV1 = 53.8% of predicted and FVC = 53.5% of predicted). There was no difference between graduates and controls with respect to activity time or total steps in step-activity monitoring, and in the exercise-tolerance test, graduates walked at the same speed but at a higher heart rate and at a significantly higher (p <0.001) VO2 cost (rate of oxygen consumed per distance traveled). The EOSQ mean score was 102.2 of a possible 120 points, and the SRS mean score was 4.1 of a possible 5 points. CONCLUSIONS: A realistic long-term goal for the management of early-onset scoliosis appears to be spine elongation and maintenance of pulmonary function at a level that is no less than the percentage of normal at initial presentation. Functional testing and patient-reported outcomes at a mean of 3 years from the last surgery suggest that activity levels were generally equal to those of controls but required greater physiologic demand. General health and physical function outcomes revealed continued impairment in these domains. LEVEL OF EVIDENCE: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
[Mh] Termos MeSH primário: Escoliose/cirurgia
Fusão Vertebral/métodos
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Fixadores Externos
Volume Expiratório Forçado/fisiologia
Seres Humanos
Lactente
Medidas de Volume Pulmonar/métodos
Osteogênese por Distração/instrumentação
Osteogênese por Distração/métodos
Consumo de Oxigênio/fisiologia
Medidas de Resultados Relatados pelo Paciente
Estudos Prospectivos
Escoliose/diagnóstico por imagem
Escoliose/fisiopatologia
Capacidade Vital/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE
[do] DOI:10.2106/JBJS.16.00796


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[PMID]:28545875
[Au] Autor:Bhatia R; Davis PG; Tingay DG
[Ad] Endereço:Newborn Research, The Royal Women's Hospital, Melbourne, Australia; Neonatal Research, Murdoch Childrens Research Institute, Melbourne, Australia; The University of Melbourne, Melbourne, Australia; Monash Newborn, Monash Children's Hospital, Melbourne, Australia. Electronic address: risha.bhatia@monashhealth.org.
[Ti] Título:Regional Volume Characteristics of the Preterm Infant Receiving First Intention Continuous Positive Airway Pressure.
[So] Source:J Pediatr;187:80-88.e2, 2017 Aug.
[Is] ISSN:1097-6833
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To determine whether applying nasal continuous positive airway pressure (CPAP) using systematic changes in continuous distending pressure (CDP) results in a quasi-static pressure-volume relationship in very preterm infants receiving first intention CPAP in the first 12-18 hours of life. STUDY DESIGN: Twenty infants at <32 weeks' gestation with mild respiratory distress syndrome (RDS) managed exclusively with nasal CPAP had CDP increased from 5 to 8 to 10 cmH O, and then decreased to 8 cmH O and returned to baseline CDP. Each CDP was maintained for 20 min. At each CDP, relative impedance change in end-expiratory thoracic volume (ΔZEEV) and tidal volume (ΔZV ) were measured using electrical impedance tomography. Esophageal pressure (P ) was measured as a proxy for intrapleural pressure to determine transpulmonary pressure (P ). RESULTS: Overall, there was a relationship between P and global ΔZEEV representing the pressure-volume relationship in the lungs. There were regional variations in ΔZEEV, with 13 infants exhibiting hysteresis with the greatest gains in EEV and tidal volume in the dependent lung with no hemodynamic compromise. Seven infants did not demonstrate hysteresis during decremental CDP changes. CONCLUSION: It was possible to define a pressure-volume relationship of the lung and demonstrate reversal of atelectasis by systematically manipulating CDP in most very preterm infants with mild RDS. This suggests that CDP manipulation can be used to optimize the volume state of the preterm lung.
[Mh] Termos MeSH primário: Pressão Positiva Contínua nas Vias Aéreas/métodos
Pulmão/fisiopatologia
Síndrome do Desconforto Respiratório do Recém-Nascido/terapia
[Mh] Termos MeSH secundário: Impedância Elétrica
Feminino
Seres Humanos
Recém-Nascido
Recém-Nascido Prematuro
Unidades de Terapia Intensiva Neonatal
Medidas de Volume Pulmonar/métodos
Masculino
Estudos Prospectivos
Síndrome do Desconforto Respiratório do Recém-Nascido/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170527
[St] Status:MEDLINE


  10 / 9279 MEDLINE  
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[PMID]:28471738
[Au] Autor:Horn FC; Marshall H; Collier GJ; Kay R; Siddiqui S; Brightling CE; Parra-Robles J; Wild JM
[Ad] Endereço:From the Unit of Academic Radiology, Department of Infection, Immunity and Cardiovascular Disease, C Floor, Royal Hallamshire Hospital, University of Sheffield, Glossop Rd, Sheffield S10 2JF, England (F.C.H., H.M., G.J.C., J.P., J.M.W.); Novartis, Basel, Switzerland (R.K.); Department of Respiratory
[Ti] Título:Regional Ventilation Changes in the Lung: Treatment Response Mapping by Using Hyperpolarized Gas MR Imaging as a Quantitative Biomarker.
[So] Source:Radiology;284(3):854-861, 2017 Sep.
[Is] ISSN:1527-1315
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose To assess the magnitude of regional response to respiratory therapeutic agents in the lungs by using treatment response mapping (TRM) with hyperpolarized gas magnetic resonance (MR) imaging. TRM was used to quantify regional physiologic response in adults with asthma who underwent a bronchodilator challenge. Materials and Methods This study was approved by the national research ethics committee and was performed with informed consent. Imaging was performed in 20 adult patients with asthma by using hyperpolarized helium 3 ( He) ventilation MR imaging. Two sets of baseline images were acquired before inhalation of a bronchodilating agent (salbutamol 400 µg), and one set was acquired after. All images were registered for voxelwise comparison. Regional treatment response, ΔR(r), was calculated as the difference in regional gas distribution (R[r] = ratio of inhaled gas to total volume of a voxel when normalized for lung inflation volume) before and after intervention. A voxelwise activation threshold from the variability of the baseline images was applied to ΔR(r) maps. The summed global treatment response map (ΔR ) was then used as a global lung index for comparison with metrics of bronchodilator response measured by using spirometry and the global imaging metric percentage ventilated volume (%VV). Results ΔR showed significant correlation (P < .01) with changes in forced expiratory volume in 1 second (r = 0.70), forced vital capacity (r = 0.84), and %VV (r = 0.56). A significant (P < .01) positive treatment effect was detected with all metrics; however, ΔR showed a lower intersubject coefficient of variation (64%) than all of the other tests (coefficient of variation, ≥99%). Conclusion TRM provides regional quantitative information on changes in inhaled gas ventilation in response to therapy. This method could be used as a sensitive regional outcome metric for novel respiratory interventions. RSNA, 2017 Online supplemental material is available for this article.
[Mh] Termos MeSH primário: Hélio/uso terapêutico
Medidas de Volume Pulmonar/métodos
Pulmão/diagnóstico por imagem
Imagem por Ressonância Magnética/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Albuterol/uso terapêutico
Algoritmos
Asma/diagnóstico por imagem
Asma/tratamento farmacológico
Biomarcadores
Broncodilatadores/uso terapêutico
Feminino
Seres Humanos
Processamento de Imagem Assistida por Computador
Masculino
Meia-Idade
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Bronchodilator Agents); 206GF3GB41 (Helium); QF8SVZ843E (Albuterol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1148/radiol.2017160532



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