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[PMID]:29214783
[Au] Autor:Lee SM; Namgung R; Eun HS; Lee SM; Park MS; Park KI
[Ad] Endereço:Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
[Ti] Título:Effective Tidal Volume for Normocapnia in Very-Low-Birth-Weight Infants Using High-Frequency Oscillatory Ventilation.
[So] Source:Yonsei Med J;59(1):101-106, 2018 Jan.
[Is] ISSN:1976-2437
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Removal of CO2 is much efficient during high-frequency oscillatory ventilation (HFOV) for preterm infants. However, an optimal carbon dioxide diffusion coefficient (DCO2) and tidal volume (VT) have not yet been established due to much individual variance. This study aimed to analyze DCO2 values, VT, and minute volume in very-low-birth-weight (VLBW) infants using HFOV and correlates with plasma CO2 (pCO2). MATERIALS AND METHODS: Daily respiratory mechanics and ventilator settings from twenty VLBW infants and their two hundred seventeen results of blood gas analysis were collected. Patients were treated with the Dräger Babylog VN500 ventilator (Drägerwerk Ag & Co.) in HFOV mode. The normocapnia was indicated as pCO2 ranging from 45 mm Hg to 55 mm Hg. RESULTS: The measured VT was 1.7 mL/kg, minute volume was 0.7 mL/kg, and DCO2 was 43.5 mL²/s. Mean results of the blood gas test were as follows: pH, 7.31; pCO2, 52.6 mm Hg; and SpO2, 90.5%. In normocapnic state, the mean VT was significantly higher than in hypercapnic state (2.1±0.5 mL/kg vs. 1.6±0.3 mL/kg), and the mean DCO2 showed significant difference (68.4±32.7 mL²/s vs. 32.4±15.7 mL²/s). The DCO2 was significantly correlated with the pCO2 (p=0.024). In the receiver operating curve analysis, the estimated optimal cut-off point to predict the remaining normocapnic status was a VT of 1.75 mL/kg (sensitivity 73%, specificity 80%). CONCLUSION: In VLBW infants treated with HFOV, VT of 1.75 mL/kg is recommended for maintaining proper ventilation.
[Mh] Termos MeSH primário: Ventilação de Alta Frequência
Recém-Nascido de muito Baixo Peso/fisiologia
[Mh] Termos MeSH secundário: Gasometria
Dióxido de Carbono/análise
Feminino
Seres Humanos
Hipercapnia/fisiopatologia
Incidência
Lactente
Recém-Nascido
Masculino
Curva ROC
Volume de Ventilação Pulmonar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
142M471B3J (Carbon Dioxide)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.3349/ymj.2018.59.1.101


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[PMID]:29237524
[Au] Autor:Li L; Chen Q; Zhang F; Zhu SG; Hu CL; Wu AM
[Ad] Endereço:Department of Respiration, Jiangxi Children's Hospital, Nanchang 330000, China. nclilan@163.com.
[Ti] Título:[Characteristics of tidal breathing pulmonary function in children with tracheobronchomalacia].
[So] Source:Zhongguo Dang Dai Er Ke Za Zhi;19(12):1248-1251, 2017 Dec.
[Is] ISSN:1008-8830
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To investigate the characteristics of tidal breathing pulmonary function in children with tracheobronchomalacia (TBM). METHODS: In this study, 30 children who were diagnosed with TBM using electronic bronchoscopy were enrolled in the observation group; 30 healthy children were recruited in the normal control group. For individuals in each group, the assessment of tidal breath pulmonary function was performed at diagnosis and 3, 6, 9, and 12 months after diagnosis. RESULTS: There were no significant differences in tidal volume, inspiratory time, expiratory time, and inspiratory to expiratory ratio between the two groups (P>0.05). Compared with the control group, the observation group had a significantly higher respiratory rate and significantly lower ratio of time to peak tidal expiratory flow to total expiratory time (TPTEF/TE) and ratio of volume to peak tidal expiratory flow to total expiratory volume (VPTEF/VE). There was a time-dependent increase in TPTEF/TE and VPTEF/VE for TBM children from the time of initial diagnosis to 12 months after diagnosis. CONCLUSIONS: Tidal breathing pulmonary function has characteristic changes in children with TBM. Tidal breathing pulmonary function tends to be recovered with increased age in children with TBM.
[Mh] Termos MeSH primário: Pulmão/fisiopatologia
Respiração
Volume de Ventilação Pulmonar
Traqueobroncomalácia/fisiopatologia
[Mh] Termos MeSH secundário: Fatores Etários
Feminino
Seres Humanos
Lactente
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE


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[PMID]:28451990
[Au] Autor:Solav D; Meric H; Rubin MB; Pradon D; Lofaso F; Wolf A
[Ad] Endereço:Faculty of Mechanical Engineering, Technion Israel Institute of Technology, 32000, Haifa, Israel. danask@mit.edu.
[Ti] Título:Chest Wall Kinematics Using Triangular Cosserat Point Elements in Healthy and Neuromuscular Subjects.
[So] Source:Ann Biomed Eng;45(8):1963-1973, 2017 08.
[Is] ISSN:1573-9686
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Optoelectronic plethysmography (OEP) is a noninvasive method for assessing lung volume variations and the contributions of different anatomical compartments of the chest wall (CW) through measurements of the motion of markers attached to the CW surface. The present study proposes a new method for analyzing the local CW kinematics from OEP measurements based on the kinematics of triangular Cosserat point elements (TCPEs). 52 reflective markers were placed on the anterior CW to create a mesh of 78 triangles according to an anatomical model. Each triangle was characterized by a TCPE and its kinematics was described using four time-variant scalar TCPE parameters. The total CW volume ([Formula: see text]) and the contributions of its six compartments were also estimated, using the same markers. The method was evaluated using measurements of ten healthy subjects, nine patients with Pompe disease, and ten patients with Duchenne muscular dystrophy (DMD), during spontaneous breathing (SB) and vital capacity maneuvers (VC) in the supine position. TCPE parameters and compartmental volumes were compared with [Formula: see text] by computing the phase angles [Formula: see text] (for SB) and the correlation r (for VC) between them. Analysis of [Formula: see text] and r of the outward translation parameter [Formula: see text] of each TCPE revealed that for healthy subjects it provided similar results to those obtained by compartmental volumes, whereas for the neuromuscular patients the TCPE method was capable of detecting local asynchronous and paradoxical movements also in cases where they were undistinguished by volumes. Therefore, the TCPE approach provides additional information to OEP that may enhance its clinical evaluation capabilities.
[Mh] Termos MeSH primário: Medidas de Volume Pulmonar/métodos
Modelos Biológicos
Doenças Neuromusculares/fisiopatologia
Fotopletismografia/métodos
Mecânica Respiratória
Parede Torácica/fisiopatologia
Volume de Ventilação Pulmonar
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Simulação por Computador
Feminino
Análise de Elementos Finitos
Doença de Depósito de Glicogênio Tipo II
Seres Humanos
Masculino
Meia-Idade
Doenças Neuromusculares/diagnóstico
Valores de Referência
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1007/s10439-017-1840-6


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[PMID]:28742774
[Au] Autor:Josephs SA; Lemmink GA; Strong JA; Barry CL; Hurford WE
[Ad] Endereço:From the Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, Ohio.
[Ti] Título:Improving Adherence to Intraoperative Lung-Protective Ventilation Strategies at a University Medical Center.
[So] Source:Anesth Analg;126(1):150-160, 2018 01.
[Is] ISSN:1526-7598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Intraoperative lung-protective ventilation (ILPV) is defined as tidal volumes <8 mL/kg ideal bodyweight and is increasingly a standard of care for major abdominal surgical procedures performed under general anesthesia. In this study, we report the result of a quality improvement initiative targeted at improving adherence to ILPV guidelines in a large academic teaching hospital. METHODS: We performed a time-series study to determine whether anesthesia provider adherence to ILPV was affected by certain improvement interventions and patient ideal body weight (IBW). Tidal volume data were collected at 3 different time points for 191 abdominal surgical cases from June 2014 through April 2015. Improvement interventions during that period included education at departmental grand rounds, creation of a departmental ILPV policy, feedback of tidal volume and failure rate data at grand rounds sessions, and reducing default ventilator settings for tidal volume. Mean tidal volume per kilogram of ideal body weight (VT/kg IBW) and rates of noncompliance with ILPV were analyzed before and after the interventions. A survey was administered to assess provider attitudes after implementation of improvement interventions. Responses before and after interventions and between physician and nonphysician providers were analyzed. RESULTS: Reductions in mean VT/kg IBW and rates of failure for providers to use ILPV occurred after improvement interventions. Patients with IBW <65 kg received higher VT/kg IBW and had higher rates of failure to use ILPV than patients with IBW >65 kg. Surveyed providers demonstrated stronger agreement to having knowledge and practice consistent with ILPV after interventions. CONCLUSIONS: Our interventions improved anesthesia provider adherence to low tidal volume ILPV. IBW was found to be an important factor related to provider adherence to ILPV. Provider attitudes about their knowledge and practice consistent with ILPV also changed with our interventions.
[Mh] Termos MeSH primário: Centros Médicos Acadêmicos/normas
Fidelidade a Diretrizes/normas
Pulmão/fisiologia
Monitorização Intraoperatória/normas
Ventilação Pulmonar/fisiologia
Respiração Artificial/normas
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Análise de Séries Temporais Interrompida/métodos
Análise de Séries Temporais Interrompida/normas
Masculino
Meia-Idade
Monitorização Intraoperatória/métodos
Respiração Artificial/métodos
Estudos Retrospectivos
Volume de Ventilação Pulmonar/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1213/ANE.0000000000002299


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[PMID]:27776149
[Au] Autor:Flueck JL; Schaufelberger F; Lienert M; Schäfer Olstad D; Wilhelm M; Perret C
[Ad] Endereço:Institute of Sports Medicine, Swiss Paraplegic Centre, Nottwil, Switzerland.
[Ti] Título:Acute Effects of Caffeine on Heart Rate Variability, Blood Pressure and Tidal Volume in Paraplegic and Tetraplegic Compared to Able-Bodied Individuals: A Randomized, Blinded Trial.
[So] Source:PLoS One;11(10):e0165034, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Caffeine increases sympathetic nerve activity in healthy individuals. Such modulation of nervous system activity can be tracked by assessing the heart rate variability. This study aimed to investigate the influence of caffeine on time- and frequency-domain heart rate variability parameters, blood pressure and tidal volume in paraplegic and tetraplegic compared to able-bodied participants. Heart rate variability was measured in supine and sitting position pre and post ingestion of either placebo or 6 mg caffeine in 12 able-bodied, 9 paraplegic and 7 tetraplegic participants in a placebo-controlled, randomized and double-blind study design. Metronomic breathing was applied (0.25 Hz) and tidal volume was recorded during heart rate variability assessment. Blood pressure, plasma caffeine and epinephrine concentrations were analyzed pre and post ingestion. Most parameters of heart rate variability did not significantly change post caffeine ingestion compared to placebo. Tidal volume significantly increased post caffeine ingestion in able-bodied (p = 0.021) and paraplegic (p = 0.036) but not in tetraplegic participants (p = 0.34). Systolic and diastolic blood pressure increased significantly post caffeine in able-bodied (systolic: p = 0.003; diastolic: p = 0.021) and tetraplegic (systolic: p = 0.043; diastolic: p = 0.042) but not in paraplegic participants (systolic: p = 0.09; diastolic: p = 0.33). Plasma caffeine concentrations were significantly increased post caffeine ingestion in all three groups of participants (p<0.05). Plasma epinephrine concentrations increased significantly in able-bodied (p = 0.002) and paraplegic (p = 0.032) but not in tetraplegic participants (p = 0.63). The influence of caffeine on the autonomic nervous system seems to depend on the level of lesion and the extent of the impairment. Therefore, tetraplegic participants may be less influenced by caffeine ingestion. TRIAL REGISTRATION: ClinicalTrials.gov NCT02083328.
[Mh] Termos MeSH primário: Pressão Sanguínea/efeitos dos fármacos
Cafeína/efeitos adversos
Frequência Cardíaca/efeitos dos fármacos
Paraplegia/fisiopatologia
Quadriplegia/fisiopatologia
Respiração/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adulto
Sistema Nervoso Autônomo/efeitos dos fármacos
Determinação da Pressão Arterial
Cafeína/sangue
Método Duplo-Cego
Epinefrina/sangue
Feminino
Seres Humanos
Masculino
Meia-Idade
Paraplegia/metabolismo
Quadriplegia/metabolismo
Volume de Ventilação Pulmonar/efeitos dos fármacos
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
3G6A5W338E (Caffeine); YKH834O4BH (Epinephrine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0165034


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[PMID]:29189358
[Au] Autor:Slinger PD
[Ad] Endereço:From the Department of Anesthesia, University of Toronto, Toronto General Hospital, Toronto, Ontario, Canada.
[Ti] Título:The Search for the Optimal Tidal Volume: Why Do We Use Body Weight?
[So] Source:Anesth Analg;125(6):1831-1832, 2017 12.
[Is] ISSN:1526-7598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Síndrome do Desconforto Respiratório do Adulto
Volume de Ventilação Pulmonar
[Mh] Termos MeSH secundário: Peso Corporal
Seres Humanos
Respiração Artificial
[Pt] Tipo de publicação:EDITORIAL; COMMENT
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180111
[Lr] Data última revisão:
180111
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1213/ANE.0000000000002046


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[PMID]:29253019
[Au] Autor:Toida C; Muguruma T; Miyamoto M
[Ad] Endereço:Division of Critical Care Medicine, National Medical Center for Children and Mothers, Tokyo, Japan.
[Ti] Título:Detection and validation of predictors of successful extubation in critically ill children.
[So] Source:PLoS One;12(12):e0189787, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Availability of objective criteria for predicting successful extubation could avoid unnecessary prolongation of mechanical ventilation and/or inadvertent premature extubation, but the predictors of successful extubation in children are unclear. This study was performed to detect and validate respiratory function predictors of successful extubation in children admitted to the pediatric critical care unit. METHODS: A retrospective chart review from 2010 to 2012 identified 463 patients, who were divided into a derivation cohort (n = 294) and a validation cohort (n = 169). RESULTS: The incidence rate of failed extubation was 5% and 9% in the derivation and validation cohorts, respectively. The optimal cut-off values of crying vital capacity (CVC), peak inspiratory flow rate (PIFR), and maximum inspiratory pressure (MIP) were 17 ml/kg, 3.5 ml/sec/cm, and 50 cmH2O, respectively. The pass rates of CVC, PIFR, and MIP were 54.2%, 92.7%, and 55.5%, respectively. In the validation cohort, the successful extubation rate was 97.9% for patients who passed all 3 respiratory tests, 88.8% for those who passed at least one test, and 66.7% for those who failed all of the tests. Extubation failed in 5 patients who passed all three respiratory tests and failure was due to postoperative respiratory muscle fatigue or upper airway impairment. CONCLUSIONS: We detected and validated predictors of successful extubation in critically ill children. A combination of CVC, PIFR, and MIP may be used to predict successful extubation for critically ill children. It is necessary to pay attention when extubating patients with postoperative respiratory muscle fatigue or upper airway impairment due to disturbance of consciousness and/or glottal edema even if they pass the respiratory function tests.
[Mh] Termos MeSH primário: Extubação/métodos
Estado Terminal
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Edema/cirurgia
Seres Humanos
Lactente
Unidades de Terapia Intensiva Pediátrica
Curva ROC
Respiração
Respiração Artificial
Testes de Função Respiratória
Estudos Retrospectivos
Volume de Ventilação Pulmonar
Desmame do Respirador
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189787


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[PMID]:28742783
[Au] Autor:Biais M; Larghi M; Henriot J; de Courson H; Sesay M; Nouette-Gaulain K
[Ti] Título:End-Expiratory Occlusion Test Predicts Fluid Responsiveness in Patients With Protective Ventilation in the Operating Room.
[So] Source:Anesth Analg;125(6):1889-1895, 2017 12.
[Is] ISSN:1526-7598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: End-expiratory occlusion test (EEOT) has been proposed to predict fluid responsiveness in mechanically ventilated intensive care unit patients. The utility of this test during low-tidal-volume ventilation remains uncertain. This study aimed to determine whether hemodynamic variations induced by EEOT could predict the effect of volume expansion in patients with protective ventilation in the operating room. METHODS: Forty-one patients undergoing neurosurgery were included. Stroke volume and pulse pressure variations were continuously recorded using pulse contour analysis before and immediately after a 30-second EEOT and after volume expansion (250 mL saline 0.9% given over 10 minutes). Patients with an increase in stroke volume ≥ 10% after volume expansion were defined as responders. RESULTS: Twenty patients were responders to fluid administration. EEOT induced a significant increase in stroke volume, which was correlated with the stroke volume changes induced by volume expansion (r = 0.55, P < .0001). A 5% increase in stroke volume during EEOT discriminated responders to volume expansion with a sensitivity of 100% (95% confidence interval [CI], 83%-100%), a specificity of 81% (95% CI, 58%-95%), a positive predictive value of 84% (95% CI, 64%-96%), and a negative predictive value of 100% (95% CI, 80%-100%). The gray zone ranged from 4% to 8%, including 17% of patients. The best pulse pressure variation threshold was 9%, with a sensitivity of 60% (95% CI, 36%-81%) and specificity of 86% (95% CI, 64%-97%). The area under the receiver operating characteristics curve generated for changes in stroke volume induced by EEOT (0.91, 95% CI, 0.81-1.00) was significantly higher than the one obtained for pulse pressure variations (0.75, 95% CI, 0.60-0.90); P < .05. CONCLUSIONS: Changes in stroke volume index induced by EEOT can predict fluid responsiveness in patients with protective ventilation in the operating room. This test may have potential applications.
[Mh] Termos MeSH primário: Expiração/fisiologia
Hidratação/métodos
Salas Cirúrgicas/métodos
Respiração Artificial/métodos
Volume Sistólico/fisiologia
Volume de Ventilação Pulmonar/fisiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Respiração com Pressão Positiva/métodos
Valor Preditivo dos Testes
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1213/ANE.0000000000002322


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[PMID]:27772682
[Au] Autor:Grock A; Weinstock MB; Jhun P; Herbert M
[Ad] Endereço:Department of Emergency Medicine, University of Southern California, Los Angeles, CA. Electronic address: andygrock@gmail.com.
[Ti] Título:Aortic Dissection! Or Is It? Sigh.
[So] Source:Ann Emerg Med;68(5):640-642, 2016 11.
[Is] ISSN:1097-6760
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Aneurisma Aórtico
Volume de Ventilação Pulmonar
[Mh] Termos MeSH secundário: Aneurisma Dissecante
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171201
[Lr] Data última revisão:
171201
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:29040312
[Au] Autor:Lin HJ; Huang CT; Hsiao HF; Chiang MC; Jeng MJ
[Ad] Endereço:Department of Respiratory Therapy, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
[Ti] Título:End-tidal carbon dioxide measurement in preterm infants with low birth weight.
[So] Source:PLoS One;12(10):e0186408, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: There are conflicting data regarding the use of end-tidal carbon dioxide (PetCO2) measurement in preterm infants. The aim of this study was to evaluate the effects of different dead space to tidal volume ratios (VD/VT) on the correlation between PetCO2 and arterial carbon dioxide pressure (PaCO2) in ventilated preterm infants with respiratory distress syndrome (RDS). METHODS: We enrolled ventilated preterm infants (with assist control mode or synchronous intermittent mandatory mode) with RDS who were treated with surfactant in this prospective study. Simultaneous PetCO2 and PaCO2 data pairs were obtained from ventilated neonates monitored using mainstream capnography. Data obtained before and after surfactant treatment were also analyzed. RESULTS: One-hundred and one PetCO2 and PaCO2 pairs from 34 neonates were analyzed. There was a moderate correlation between PetCO2 and PaCO2 values (r = 0.603, P < 0.01). The correlation was higher in the post-surfactant treatment group (r = 0.786, P < 0.01) than the pre-surfactant treatment group (r = 0.235). The values of PaCO2 and PetCO2 obtained based on the treatment stage of surfactant therapy were 42.4 ± 8.6 mmHg and 32.6 ± 7.2 mmHg, respectively, in pre-surfactant treatment group, and 37.8 ± 10.3 mmHg and 33.7 ± 9.3 mmHg, respectively, in the post-surfactant treatment group. Furthermore, we found a significant decrease in VD/VT in the post-surfactant treatment group when compared to the pre-surfactant treatment group (P = 0.003). CONCLUSIONS: VD/VT decreased significantly after surfactant therapy and the correlation between PetCO2 and PaCO2 was higher after surfactant therapy in preterm infants with RDS.
[Mh] Termos MeSH primário: Dióxido de Carbono/análise
Surfactantes Pulmonares/uso terapêutico
Síndrome do Desconforto Respiratório do Recém-Nascido/diagnóstico
Síndrome do Desconforto Respiratório do Recém-Nascido/terapia
[Mh] Termos MeSH secundário: Gasometria
Dióxido de Carbono/metabolismo
Feminino
Idade Gestacional
Seres Humanos
Recém-Nascido de Baixo Peso
Recém-Nascido
Recém-Nascido Prematuro
Masculino
Monitorização Fisiológica
Pressão Parcial
Estudos Prospectivos
Respiração Artificial
Espaço Morto Respiratório/fisiologia
Síndrome do Desconforto Respiratório do Recém-Nascido/fisiopatologia
Volume de Ventilação Pulmonar/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pulmonary Surfactants); 142M471B3J (Carbon Dioxide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171018
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186408



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