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[PMID]:28459622
[Au] Autor:Martinez CH; Murray S; Barr RG; Bleecker E; Bowler RP; Christenson SA; Comellas AP; Cooper CB; Couper D; Criner GJ; Curtis JL; Dransfield MT; Hansel NN; Hoffman EA; Kanner RE; Kleerup E; Krishnan JA; Lazarus SC; Leidy NK; O'Neal W; Martinez FJ; Paine R; Rennard SI; Tashkin DP; Woodruff PG; Han MK; Subpopulations and Intermediate Outcome Measures in COPD Study Investigators
[Ad] Endereço:1 Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, Michigan.
[Ti] Título:Respiratory Symptoms Items from the COPD Assessment Test Identify Ever-Smokers with Preserved Lung Function at Higher Risk for Poor Respiratory Outcomes. An Analysis of the Subpopulations and Intermediate Outcome Measures in COPD Study Cohort.
[So] Source:Ann Am Thorac Soc;14(5):636-642, 2017 May.
[Is] ISSN:2325-6621
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Ever-smokers without airflow obstruction scores greater than or equal to 10 on the COPD Assessment Test (CAT) still have frequent acute respiratory disease events (exacerbation-like), impaired exercise capacity, and imaging abnormalities. Identification of these subjects could provide new opportunities for targeted interventions. OBJECTIVES: We hypothesized that the four respiratory-related items of the CAT might be useful for identifying such individuals, with discriminative ability similar to CAT, which is an eight-item questionnaire used to assess chronic obstructive pulmonary disease impact, including nonrespiratory questions, with scores ranging from 0 to 40. METHODS: We evaluated ever-smoker participants in the Subpopulations and Intermediate Outcomes in COPD Study without airflow obstruction (FEV /FVC ≥0.70; FVC above the lower limit of normal). Using the area under the receiver operating characteristic curve, we compared responses to both CAT and the respiratory symptom-related CAT items (cough, phlegm, chest tightness, and breathlessness) and their associations with longitudinal exacerbations. We tested agreement between the two strategies (κ statistic), and we compared demographics, lung function, and symptoms among subjects identified as having high symptoms by each strategy. RESULTS: Among 880 ever-smokers with normal lung function (mean age, 61 yr; 52% women) and using a CAT cutpoint greater than or equal to 10, we classified 51.8% of individuals as having high symptoms, 15.3% of whom experienced at least one exacerbation during 1-year follow-up. After testing sensitivity and specificity of different scores for the first four questions to predict any 1-year follow-up exacerbation, we selected cutpoints of 0-6 as representing a low burden of symptoms versus scores of 7 or higher as representing a high burden of symptoms for all subsequent comparisons. The four respiratory-related items with cutpoint greater than or equal to 7 selected 45.8% participants, 15.6% of whom experienced at least one exacerbation during follow-up. The two strategies largely identified the same individuals (agreement, 88.5%; κ = 0.77; P < 0.001), and the proportions of high-symptoms subjects who had severe dyspnea were similar between CAT and the first four CAT questions (25.9% and 26.8%, respectively), as were the proportions reporting impaired quality of life (66.9% and 70.5%, respectively) and short walking distance (22.4% and 23.1%, respectively). There was no difference in area under the receiver operating characteristic curve to predict 1-year follow-up exacerbations (CAT score ≥10, 0.66; vs. four respiratory items from CAT ≥7 score, 0.65; P = 0.69). Subjects identified by either method also had more depression/anxiety symptoms, poor sleep quality, and greater fatigue. CONCLUSIONS: Four CAT items on respiratory symptoms identified high-risk symptomatic ever-smokers with preserved spirometry as well as the CAT did. These data suggest that simpler strategies can be developed to identify these high-risk individuals in primary care.
[Mh] Termos MeSH primário: Progressão da Doença
Pulmão/fisiopatologia
Doença Pulmonar Obstrutiva Crônica/fisiopatologia
Fumar/fisiopatologia
[Mh] Termos MeSH secundário: Idoso
Biomarcadores
Estudos Transversais
Feminino
Volume Expiratório Forçado
Seres Humanos
Estudos Longitudinais
Masculino
Meia-Idade
Avaliação de Resultados (Cuidados de Saúde)
Estudos Prospectivos
Qualidade de Vida
Curva ROC
Índice de Gravidade de Doença
Fumar/efeitos adversos
Espirometria
Inquéritos e Questionários
Estados Unidos
Capacidade Vital
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1513/AnnalsATS.201610-815OC


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[PMID]:29317387
[Au] Autor:Keeley D; Baxter N
[Ad] Endereço:Primary Care Respiratory Society UK, Solihull, UK duncan.keeley@nhs.net.
[Ti] Título:Conflicting asthma guidelines cause confusion in primary care.
[So] Source:BMJ;360:k29, 2018 01 09.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Asma/diagnóstico
Asma/terapia
Guias de Prática Clínica como Assunto
Atenção Primária à Saúde/normas
[Mh] Termos MeSH secundário: Administração por Inalação
Corticosteroides/administração & dosagem
Corticosteroides/uso terapêutico
Asma/economia
Asma/epidemiologia
Inglaterra/epidemiologia
Seres Humanos
Antagonistas de Leucotrienos/uso terapêutico
Espirometria
[Pt] Tipo de publicação:EDITORIAL
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Leukotriene Antagonists)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.k29


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[PMID]:29297639
[Au] Autor:Tikhonova IV; Kosyakova NI; Tankanag AV; Chemeris NK
[Ti] Título:Effects of the Airway Obstruction on the Skin Microcirculation in Patients with Bronchial Asthma.
[So] Source:Vestn Ross Akad Med Nauk;71(3):233-9, 2016.
[Is] ISSN:0869-6047
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:Background: Pulmonary hemodynamic disorders depend on the inflammatory phases and severity of the obstructive syndrome. However, the effect of asthma bronchial obstruction on the state of peripheral hemodynamics remains insufficiently known. Aims: To study the effects of airway obstruction on skin blood flow parameters and its regulatory systems in patients with persistent atopic bronchial asthma in the remission state. Materials and Methods: A comparative study of the skin peripheral blood flow in patients with bronchial asthma with severe airway obstruction (1st group) and without obstruction (2nd group) was conducted. 20 patients with confirmed diagnosis of atopic asthma of 50­74 years old participated in the study. All patients received basic therapy in a constant dosing of high doses of inhaled glucocorticosteroids/long-acting beta-2-agonists. The control group included 20 healthy volunteers without evidence of bronchial obstruction. The study lasted for 3 months. The forced expiratory volume in 1 s (FEV1) was used to evaluate the bronchial obstruction by spirometry technique. Skin blood perfusion changes were recorded by laser Doppler flowmetry at rest and in response to short-term local ischemia. Registered peripheral blood flow signals were examined using the amplitude temporal filtering in five frequency intervals to identify the functional features of the peripheral blood flow regulation systems. Results: Consistent two-fold decrease of the oscillation amplitudes was found in the neurogenic interval at rest (p=0.031), as well as in the myogenic (p=0.043; p=0.031) and endothelial intervals (p=0.037; p≤0.001) both at rest and during the postocclusive reactive hyperemia respectively in the 1st group of patients with bronchial obstruction (FEV1 <80%) compared with the control group. No significant changes were revealed for skin blood flow parameters in the 2nd patient group (without obstruction, FEV1 >80%) in comparison to control subjects. Conclusions: The presence of bronchial obstruction has a significant impact on the changes of the amplitudes of skin blood flow oscillations in patients with bronchial asthma in the myogenic, neurogenic and endothelial intervals.
[Mh] Termos MeSH primário: Obstrução das Vias Respiratórias
Asma/fisiopatologia
Microcirculação
Pele
[Mh] Termos MeSH secundário: Idoso
Obstrução das Vias Respiratórias/diagnóstico
Obstrução das Vias Respiratórias/etiologia
Obstrução das Vias Respiratórias/fisiopatologia
Asma/complicações
Feminino
Seres Humanos
Hiperemia/diagnóstico
Fluxometria por Laser-Doppler/métodos
Masculino
Meia-Idade
Pele/irrigação sanguínea
Pele/fisiopatologia
Espirometria/métodos
Estatística como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE
[do] DOI:10.15690/vramn661


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[PMID]:27776510
[Au] Autor:Nitschke M; Appleton SL; Li Q; Tucker GR; Shah P; Bi P; Pisaniello DL; Adams RJ
[Ad] Endereço:Department for Health and Ageing, 11 Hindmarsh Square, Adelaide, South Australia, Australia. monika.nitschke@health.sa.gov.au.
[Ti] Título:Lung function reductions associated with motor vehicle density in chronic obstructive pulmonary disease: a cross-sectional study.
[So] Source:Respir Res;17(1):138, 2016 10 24.
[Is] ISSN:1465-993X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Motor vehicle-related air pollution can potentially impair lung function. The effect of pollution in people with compromised pulmonary function such as in COPD has not been previously investigated. To examine the association of lung function with motor vehicle density in people with spirometrically determined COPD in a cross-sectional study. METHODS: In 2004-06, The North West Adelaide Health Study (NWAHS), a biomedical cohort of adults assessed pre and post-bronchodilator spirometry (n = 3,103). Traffic density, obtained from the motor vehicle inventory maintained by the South Australian Environment Protection Authority, was expressed as the daily numbers of vehicles travelling within a 200 m diameter zone around participants' geocoded residences. RESULTS: In subjects with COPD (FEV /FVC <0.7, n = 221, 7.1 %), increasing daily vehicle density was associated with statistically significant decreases in lung function parameters after adjustment for smoking and socio-economic variables. Mean (95 % CI) post-bronchodilator % predicted FEV was 81 % (76-87) in the low (≤7179/day) compared with 71 % (67-75) in the high (≥15,270/day) vehicle exposure group (p < 0.05). Linear regression analysis in all subjects with COPD showed significant decrements in post-bronchodilator FEV /FVC ratio and % predicted FEV of 0.03 and 0.05 % respectively per daily increase in 1000 vehicles. In men with COPD (n = 150), the corresponding reductions were 0.03 and 0.06 %. Smaller, non-significant decrements were seen in females. No difference was seen in those without COPD. CONCLUSIONS: Vehicle traffic density was associated with significant reductions in lung function in people with COPD. Urban planning should consider the health impacts for those with pre-existing respiratory conditions.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/efeitos adversos
Exposição por Inalação/efeitos adversos
Pulmão/efeitos dos fármacos
Doença Pulmonar Obstrutiva Crônica/fisiopatologia
Emissões de Veículos/toxicidade
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Estudos Transversais
Progressão da Doença
Monitoramento Ambiental
Feminino
Volume Expiratório Forçado
Seres Humanos
Modelos Lineares
Pulmão/fisiopatologia
Masculino
Meia-Idade
Veículos Automotores
Doença Pulmonar Obstrutiva Crônica/diagnóstico
Doença Pulmonar Obstrutiva Crônica/epidemiologia
Fatores de Risco
Austrália do Sul/epidemiologia
Espirometria
Saúde da População Urbana
Capacidade Vital
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Vehicle Emissions)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


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[PMID]:29320566
[Au] Autor:Voldby C; Green K; Rosthøj S; Kongstad T; Philipsen L; Buchvald F; Skov M; Pressler T; Gustafsson P; Nielsen KG
[Ad] Endereço:CF-Centre Copenhagen, Paediatric Pulmonary Service, University of Copenhagen, Copenhagen, Denmark.
[Ti] Título:The effect of time-of-day and chest physiotherapy on multiple breath washout measures in children with clinically stable cystic fibrosis.
[So] Source:PLoS One;13(1):e0190894, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In this pilot study we investigated daytime variation of multiple breath nitrogen washout (N2MBW) measures in children with clinically stable cystic fibrosis. To our knowledge the effect of time-of-day on multiple breath washout measures in patients with cystic fibrosis has not previously been reported. Furthermore, we assessed the influence of chest physiotherapy on N2MBW measures. METHODS: Ten school children with cystic fibrosis performed N2MBW followed by spirometry and plethysmography in the morning and afternoon at three visits that were one month apart. Chest physiotherapy was performed immediately before the afternoon measurements at visit 2 and immediately before morning and afternoon measurements at visit 3. The influence of time-of-day and chest physiotherapy on the measures was evaluated using linear mixed models. RESULTS: There were adequate quality data from 8 children with median age (range) 9.6 (6.0; 15.1) years. Baseline lung clearance index (LCI) (range) was 9.0 (7.1; 13.0) and baseline FEV1% predicted was 97.5 (78.5; 117.9). No N2MBW measures were significantly influenced by time-of-day or chest physiotherapy. LCI (95% confidence interval) decreased non-significantly 0.05 (-0.32; 0.22) during the day and increased non-significantly 0.08 (-0.26; 0.42) after chest physiotherapy. All spirometric measures were unaffected by time-of-day and chest physiotherapy. For plethysmographic measures FRCpleth decreased significantly (p<0.01) 110 mL during the day, whereas a borderline significant (p = 0.046) decrease in ΔFRCpleth-MBW during the day and a borderline significant (p = 0.03) increase in TLC after CPT were observed. CONCLUSION: This study demonstrated that the time-of-day as well as chest physiotherapy performed immediately prior to N2MBW had no consistent or significant influence on N2MBW measures. However, we emphasize that further studies of the effect of both daytime variation and the effect of chest physiotherapy on multiple breath washout measures are warranted.
[Mh] Termos MeSH primário: Fibrose Cística/fisiopatologia
Fibrose Cística/reabilitação
Modalidades de Fisioterapia
[Mh] Termos MeSH secundário: Adolescente
Testes Respiratórios
Criança
Feminino
Seres Humanos
Masculino
Nitrogênio/metabolismo
Projetos Piloto
Pletismografia
Estudos Prospectivos
Respiração
Espirometria
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
N762921K75 (Nitrogen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190894


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[PMID]:29211208
[Au] Autor:Meneghini AC; Paulino ACB; Pereira LP; Vianna EO
[Ad] Endereço:MSc. Doctoral Student, Department of Social Medicine, Faculdade de Medicina de Ribeirão Preto (FMRP), Universidade de São Paulo (USP), Ribeirão Preto (SP), Brazil.
[Ti] Título:Accuracy of spirometry for detection of asthma: a cross-sectional study.
[So] Source:Sao Paulo Med J;135(5):428-433, 2017 Sep-Oct.
[Is] ISSN:1806-9460
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Asthma is a chronic inflammatory disease with airway hyperresponsiveness. Spirometry is the most commonly used test among asthmatic patients. Another functional test used for diagnosing asthma is the bronchial challenge test. The aim of this study was to analyze the accuracy of spirometry for detecting asthma in the general population. DESIGN AND SETTING: Cross-sectional study with data analysis to evaluate the accuracy of spirometry through calculating sensitivity, specificity and predictive values and through the kappa agreement test. METHODS: Subjects who constituted a birth cohort were enrolled at the age of 23 to 25 years. Spirometric abnormality was defined as reduced forced expiratory volume in one second, i.e. lower than 80% of the predicted value. Measurement of bronchial responsiveness was performed by means of the bronchial challenge test with methacholine. The gold-standard diagnosis of asthma was defined as the presence of bronchial hyperresponsiveness in association with respiratory symptoms. RESULTS: Asthma was detected in 200 subjects (10.4%) out of the sample of 1922 individuals. Spirometric abnormality was detected in 208 subjects (10.9%) of the sample. The specificity of spirometric abnormality for detecting asthma was 90%, sensitivity was 23%, positive predictive value was 22%, and negative predictive value was 91%. The kappa test revealed weak agreement of 0.13 (95% confidence interval, CI: 0.07-0.19) between spirometry and the diagnosis of asthma. CONCLUSION: Spirometry, as a single test, has limitations for detecting asthma in the general population.
[Mh] Termos MeSH primário: Asma/diagnóstico
Espirometria
[Mh] Termos MeSH secundário: Adolescente
Asma/epidemiologia
Brasil/epidemiologia
Testes de Provocação Brônquica
Broncoconstritores
Criança
Pré-Escolar
Estudos Transversais
Feminino
Seres Humanos
Lactente
Masculino
Cloreto de Metacolina
Valor Preditivo dos Testes
Sensibilidade e Especificidade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bronchoconstrictor Agents); 0W5ETF9M2K (Methacholine Chloride)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


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[PMID]:27779308
[Au] Autor:Flunker JC; Clouser JM; Mannino D; Swanberg J
[Ad] Endereço:Department of Epidemiology, College of Public Health, University of Kentucky, Lexington, Kentucky.
[Ti] Título:Pulmonary function among Latino thoroughbred horse farmworkers.
[So] Source:Am J Ind Med;60(1):35-44, 2017 Jan.
[Is] ISSN:1097-0274
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Latino thoroughbred workers may be at risk for developing abnormal pulmonary function related to occupational exposures. METHODS: Eighty worker participants were recruited via community-based purposive sampling. Questionnaires and spirometry tests were administered by trained lay health promoters. Demographic and occupational factors were assessed for associations with respiratory outcomes via multivariable logistic regression. RESULTS: Twenty-seven percent of participants exhibited abnormal pulmonary function (primarily restrictive), 79% reported any respiratory symptoms, and 94% infrequently used dust masks. Shorter duration of both current horse farm employment (≤5 years) and time living in the United States (≤10 years) increased the odds of abnormal pulmonary function. Shorter time living in the United States increased the odds of upper respiratory symptoms and shorter duration of current horse farm employment increased the odds of lower respiratory symptoms. CONCLUSIONS: Abnormal pulmonary function was high among this vulnerable worker group, suggesting the need for increased dust mask usage and further exposure assessment. Am. J. Ind. Med. 60:35-44, 2017. © 2016 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Doenças dos Trabalhadores Agrícolas/epidemiologia
Poluição do Ar em Ambientes Fechados/efeitos adversos
Criação de Animais Domésticos
Hispano-Americanos
Exposição por Inalação/efeitos adversos
Doenças Respiratórias/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Doenças dos Trabalhadores Agrícolas/etiologia
Doenças dos Trabalhadores Agrícolas/fisiopatologia
Animais
Tosse/epidemiologia
Tosse/etiologia
Estudos Transversais
Poeira
Dispneia/epidemiologia
Dispneia/etiologia
Feminino
Volume Expiratório Forçado
Inquéritos Epidemiológicos
Cavalos
Seres Humanos
Kentucky/epidemiologia
Pulmão/fisiopatologia
Masculino
Meia-Idade
Projetos Piloto
Sons Respiratórios/etiologia
Doenças Respiratórias/etiologia
Doenças Respiratórias/fisiopatologia
Autorrelato
Espirometria
Capacidade Vital
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dust)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180109
[Lr] Data última revisão:
180109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1002/ajim.22667


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[PMID]:29095316
[Au] Autor:Suh Y; Lee C
[Ad] Endereço:Department of Bioinformatics and Life Science, Soongsil University, Seoul, Korea.
[Ti] Título:Genome-wide association study for genetic variants related with maximal voluntary ventilation reveals two novel genomic signals associated with lung function.
[So] Source:Medicine (Baltimore);96(44):e8530, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Genome-wide association studies (GWAS) for spirometry parameters have been limited to forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and their ratio. This study examined to identify genetic variants associated with maximal voluntary ventilation (MVV), an important spirometry parameter presenting inspiratory muscle strength.A total of 8842 Korean subjects participated in the Korean Association REsource Consortium were used to identify nucleotide variants associated with MVV and other spirometry parameters through a GWAS. Genetic associations were determined by employing a mixed model that can control background polygenic effects.The analysis revealed 3 nucleotide variants associated with MVV (P < 5 × 10). One (rs1496255) was also associated with FVC and FEV1. The other 2 variants were identified only for MVV and located in the genes of LOC102724340 (rs41434646) and FHIT (rs9833533). In particular, FHIT represses transcriptional activity of ß-catenin, a critical protein for growth of skeletal muscle, and thus might have influenced the level of MVV.The current study revealed 2 novel nucleotide variants as genetic association signals for MVV. The association signals were suggested specific for neuromuscular diseases with a restrictive ventilatory impairment. Further studies are required to understand underlying mechanisms for their influence to restrictive lung diseases.
[Mh] Termos MeSH primário: Hidrolases Anidrido Ácido/genética
Grupo com Ancestrais do Continente Asiático/genética
Variação Genética
Pneumopatias/genética
Ventilação Voluntária Máxima/genética
Proteínas de Neoplasias/genética
[Mh] Termos MeSH secundário: Proteínas de Transporte/genética
Feminino
Volume Expiratório Forçado/genética
Estudo de Associação Genômica Ampla
Seres Humanos
Pulmão/fisiologia
Masculino
Glicoproteínas de Membrana/genética
República da Coreia
Espirometria/métodos
Capacidade Vital/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carrier Proteins); 0 (HHIP protein, human); 0 (Membrane Glycoproteins); 0 (Neoplasm Proteins); 0 (fragile histidine triad protein); EC 3.6.- (Acid Anhydride Hydrolases)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171103
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008530


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[PMID]:29065164
[Au] Autor:Gjellesvik TI; Brurok B; Tjønna AE; Tørhaug T; Askim T
[Ad] Endereço:Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Science, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
[Ti] Título:Oxygen uptake during functional activities after stroke-Reliability and validity of a portable ergospirometry system.
[So] Source:PLoS One;12(10):e0186894, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: People with stroke have a low peak aerobic capacity and experience increased effort during performance of daily activities. The purpose of this study was to examine test-retest reliability of a portable ergospirometry system in people with stroke during performance of functional activities in a field-test. Secondary aims were to examine the proportion of oxygen consumed during the field-test in relation to the peak-test and to analyse the correlation between the oxygen uptake during the field-test and peak-test in order to support the validity of the field-test. METHODS: With simultaneous measurement of oxygen consumption, participants performed a standardized field-test consisting of five activities; walking over ground, stair walking, stepping over obstacles, walking slalom between cones and from a standing position lifting objects from one height to another. All activities were performed in self-selected speed. Prior to the field-test, a peak aerobic capacity test was performed. The field-test was repeated minimum 2 and maximum 14 days between the tests. ICC2,1 and Bland Altman tests (Limits of Agreement, LoA) were used to analyse test-retest reliability. RESULTS: In total 31 participants (39% women, mean (SD) age 54.5 (12.7) years and 21.1 (14.3) months' post-stroke) were included. The ICC2,1 was ≥ 0.80 for absolute V̇O2, relative V̇O2, minute ventilation, CO2, respiratory exchange ratio, heart rate and Borgs rating of perceived exertion. ICC2,1 for total time to complete the field-test was 0.99. Mean difference in steady state V̇O2 during Test 1 and Test 2 was -0.40 (2.12) The LoAs were -3.75 and 4.51. Participants spent 60.7% of their V̇O2peak performing functional activities. Correlation between field-test and peak-test was 0.689, p = 0.001 for absolute and 0.733, p = 0.001 for relative V̇O2. CONCLUSIONS: This study presents first evidence on reliability of oxygen uptake during performance of functional activities after stroke, showing very good test-retest reliability. The secondary analysis showed that the amount of energy spent during the field-test relative to the peak-test was high and the correlation between the two test was good, supporting the validity of this method.
[Mh] Termos MeSH primário: Oxigênio/metabolismo
Espirometria/instrumentação
Acidente Vascular Cerebral/metabolismo
[Mh] Termos MeSH secundário: Adulto
Cognição
Feminino
Marcha
Seres Humanos
Masculino
Meia-Idade
Consumo de Oxigênio
Equilíbrio Postural
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
S88TT14065 (Oxygen)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171025
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186894


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[PMID]:29016655
[Au] Autor:Reinhold D; Morrow JD; Jacobson S; Hu J; Ringel B; Seibold MA; Hersh CP; Kechris KJ; Bowler RP
[Ad] Endereço:Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Denver, Aurora, Colorado, United States of America.
[Ti] Título:Meta-analysis of peripheral blood gene expression modules for COPD phenotypes.
[So] Source:PLoS One;12(10):e0185682, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chronic obstructive pulmonary disease (COPD) occurs typically in current or former smokers, but only a minority of people with smoking history develops the disease. Besides environmental factors, genetics is an important risk factor for COPD. However, the relationship between genetics, environment and phenotypes is not well understood. Sample sizes for genome-wide expression studies based on lung tissue have been small due to the invasive nature of sample collection. Increasing evidence for the systemic nature of the disease makes blood a good alternative source to study the disease, but there have also been few large-scale blood genomic studies in COPD. Due to the complexity and heterogeneity of COPD, examining groups of interacting genes may have more relevance than identifying individual genes. Therefore, we used Weighted Gene Co-expression Network Analysis to find groups of genes (modules) that are highly connected. However, module definitions may vary between individual data sets. To alleviate this problem, we used a consensus module definition based on two cohorts, COPDGene and ECLIPSE. We studied the relationship between the consensus modules and COPD phenotypes airflow obstruction and emphysema. We also used these consensus module definitions on an independent cohort (TESRA) and performed a meta analysis involving all data sets. We found several modules that are associated with COPD phenotypes, are enriched in functional categories and are overrepresented for cell-type specific genes. Of the 14 consensus modules, three were strongly associated with airflow obstruction (meta p ≤ 0.0002), and two had some association with emphysema (meta p ≤ 0.06); some associations were stronger in the case-control cohorts, and others in the cases-only subcohorts. Gene Ontology terms that were overrepresented included "immune response" and "defense response." The cell types whose type-specific genes were overrepresented in modules (p < 0.05) included natural killer cells, dendritic cells, and neutrophils. Together, this is the largest investigation of gene blood expression in COPD with 469 cases in COPDGene, ECLIPSE and TESRA combined, with 6267 genes common to all data sets. Additional, we have 42 and 83 controls in COPDGene and ECLIPSE, respectively.
[Mh] Termos MeSH primário: Interação Gene-Ambiente
Genômica
Doença Pulmonar Obstrutiva Crônica/sangue
Enfisema Pulmonar/sangue
[Mh] Termos MeSH secundário: Epistasia Genética
Expressão Gênica/genética
Ontologia Genética
Seres Humanos
Monócitos/metabolismo
Monócitos/patologia
Neutrófilos/metabolismo
Neutrófilos/patologia
Doença Pulmonar Obstrutiva Crônica/genética
Doença Pulmonar Obstrutiva Crônica/fisiopatologia
Enfisema Pulmonar/genética
Fatores de Risco
Espirometria
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171011
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185682



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