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[PMID]:29465542
[Au] Autor:Huang L; Huang Z; Tai Y; Wang P; Hu B; Tang C
[Ad] Endereço:Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.
[Ti] Título:The small bowel diseases detected by capsule endoscopy in patients with chronic abdominal pain: A retrospective study.
[So] Source:Medicine (Baltimore);97(8):e0025, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chronic abdominal pain (CAP) remains a particular challenge because of its complicated causes, especially when the disorders involve the small bowel, where it is quite difficult to intubate the flexible endoscopes. This study was to investigate the small bowel diseases detected by capsule endoscopy (CE) in CAP patients to evaluate the role of CE on CAP, and analyzed the relationship among the clinical characteristics of CAP patients and the positive rates of CE findings to search for the indications of CE for CAP patients.This retrospective study included 341 patients with CAP defined as recurrent abdominal pain for no <3 months. Each patient underwent CE after a negative diagnostic work-up. All CE images were reviewed by 3 gastroenterologists independently. The positive findings were defined as abnormal findings in the small bowel that might have been the causes of CAP. The final diagnosis was confirmed by CE findings, clinical features, histopathology, and a response to the treatment during the follow-up for at least 3 months after CE.The overall positive rate of CE findings was 28.15% (96/341). The positive rate in CAP-A (CAP with associated symptoms) group was significantly higher than that in CAP-O (CAP only) group (33.16% vs 21.38%, P = .017). Multivariate logistic regression analysis revealed that weight loss (odds ratio [OR] = 2.827, 95% confidence interval (CI) = 1.938-4.926), hypoalbuminemia (OR = 6.142, 95%IC = 4.129-8.274), elevated erythrocyte sedimentation rate (ESR) (OR = 4.025, 95%IC = 3.178-6.892), or increased C-reactive protein (CRP) (OR = 7.539, 95%CI = 5.365-11.723) were significantly associated with high positive rates. On follow-up, final diagnosis was confirmed in 56 of 69 (81.16%) patients with positive CE findings. About half of these patients (46.38%, 32/69) were diagnosed as inflammatory diseases, including Crohn disease (12), tuberculosis (5), NSAID enteropathy (4), etc. Tumors were proved in 21.74% (15/69) patients, including malignant in 7 cases and benign in 8 cases. Parasitosis was found in 9 (13.04%) patients.This study suggests that CE may be helpful for CAP patients to detect the small bowel diseases, half of which were comprised of inflammatory diseases. Besides, weight loss, hypoalbuminemia, elevated ESR, or increased CRP may be regarded as the indications of CE for CAP patients.
[Mh] Termos MeSH primário: Dor Abdominal/etiologia
Endoscopia por Cápsula/métodos
Dor Crônica/etiologia
Enteropatias/diagnóstico por imagem
Intestino Delgado/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Sedimentação Sanguínea
Proteína C-Reativa/análise
Feminino
Seres Humanos
Hipoalbuminemia/complicações
Modelos Logísticos
Masculino
Meia-Idade
Estudos Retrospectivos
Perda de Peso
Adulto Jovem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
9007-41-4 (C-Reactive Protein)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180222
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000010025


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[PMID]:29368483
[Au] Autor:Ahmed R; Davitt J; Rayyan Y
[Ti] Título:Using Capsule Endoscopy at an Academic Teaching Hospital in West Virginia: A Descriptive Analysis of our 7 year Experience and Determination of Diagnostic Yield for Obscure Gastrointestinal Bleeding.
[So] Source:W V Med J;112(5):54-8, 2016 Sep-Oct.
[Is] ISSN:0043-3284
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background: The aim of our study was to describe, analyze, and evaluate results of wireless capsule endoscopy (CE) as an imaging modality for various indications. Methods: We conducted a retrospective chart review study of all CE studies performed between January 1, 2007 and June 30, 2014 at Marshall University. The study included 272 patients between the ages of 21-85 years old. Results: The most common finding in our study was a normal study (57.7%) followed by small bowel erosions (14.3%), neoplasms (11.4%), Arteriovenous malformations (10.7%), inflammatory bowel disease (2.6%), and nonspecific findings (3.3%). Discussion: 90/209 patients who had indications for IDA, melena, or heme-positive stools demonstrated positive findings by CE; our diagnostic yield for obscure GI bleeding was therefore 43.1%.
[Mh] Termos MeSH primário: Endoscopia por Cápsula
Hemorragia Gastrointestinal/diagnóstico
Hospitais Universitários
[Mh] Termos MeSH secundário: Centros Médicos Acadêmicos
Adulto
Idoso
Idoso de 80 Anos ou mais
Endoscopia por Cápsula/métodos
Diagnóstico Diferencial
Feminino
Seres Humanos
Enteropatias/diagnóstico
Neoplasias do Jejuno/diagnóstico
Masculino
Meia-Idade
Valor Preditivo dos Testes
Reprodutibilidade dos Testes
Estudos Retrospectivos
Sensibilidade e Especificidade
West Virginia
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE


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[PMID]:29390483
[Au] Autor:Kim JH; Yoon HH; Jeong SH; Woo HS; Lee WS; Choi SJ; Kim SG; Ha SY; Kwon KA
[Ad] Endereço:Department of Internal Medicine, Gachon University Gil Medical Center, Gachon University School of Medicine, Incheon.
[Ti] Título:Spontaneous peeled ileal giant lipoma caused by lower gastrointestinal bleeding: A case report.
[So] Source:Medicine (Baltimore);96(51):e9253, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Gastrointestinal subepithelial tumors (SETs) with endoscopic features such as ulceration, a red color change, a peeled mucosal layer, and spontaneous bleeding could have malignant potential. However, we encountered a case of a lipoma that presented features different from the generally known features of gastrointestinal SETs. Therefore, we report an interesting rare case of a terminal ileal giant lipoma with a unique feature of spontaneous peeled ulceration on the surface on endoscopy that caused gastrointestinal bleeding. PATIENT: An 82-year-old woman with a 1-week history of abdominal pain and hematochezia presented to our hospital. DIAGNOSES: Ileocolonoscopy revealed a SET with a peeled surface and erythematous and ulcerative mucosal changes as well as exposed a submucosal mass at the terminal ileum. Macroscopically, the lesion appeared as a yellowish pedunculated polypoid mass measuring 3 × 2 cm with a peeled mucosal ulceration. Histopathological findings revealed a submucosal lipoma of the terminal ileum. INTERVENTION: We thought that the endoscopic finding indicated malignant SETs or those with malignant potential rather than benign SETs. Therefore, the patient underwent an elective laparoscopic ileocecectomy. LESSONS: We encountered a lipoma that did not present with the typical features of gastrointestinal SETs. Our findings suggest that clinicians should consider that benign SETs in the terminal ileum may present with various endoscopic findings similar to those of malignant SETs, which can cause fatal symptoms and signs.
[Mh] Termos MeSH primário: Hemorragia Gastrointestinal/etiologia
Íleo/cirurgia
Neoplasias Intestinais/patologia
Laparoscopia/métodos
Lipoma/patologia
[Mh] Termos MeSH secundário: Dor Abdominal/diagnóstico
Dor Abdominal/etiologia
Idoso de 80 Anos ou mais
Endoscopia por Cápsula/métodos
Feminino
Seguimentos
Hemorragia Gastrointestinal/cirurgia
Seres Humanos
Íleo/patologia
Mucosa Intestinal/patologia
Mucosa Intestinal/cirurgia
Neoplasias Intestinais/complicações
Neoplasias Intestinais/diagnóstico por imagem
Neoplasias Intestinais/cirurgia
Lipoma/complicações
Lipoma/diagnóstico por imagem
Lipoma/cirurgia
Medição de Risco
Índice de Gravidade de Doença
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009253


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[PMID]:29390561
[Au] Autor:Liu T; Zhang S; Mao H
[Ad] Endereço:Department of Gastroenterology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
[Ti] Título:Gastrointestinal malignant neoplasms disguised as pneumatosis cystoids intestinalis: A case report and literature review.
[So] Source:Medicine (Baltimore);96(51):e9410, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Pneumatosis cystoids intestinalis (PCI) is a rare disease in which gas develops in the mucosa or submucosa of the digestive tract. The etiology and pathogenesis of this disease, at present, remain unclear, and gastrointestinal malignant neoplasms may be a potentially important cause. Herein, we report a case of mantle cell lymphoma presenting as PCI as well as present a literature review of cases of suspect PCI that was definitively diagnosed as gastrointestinal neoplasms. In doing so, we highlighted cases of neoplastic pathogenesis that present as PCI. PATIENT CONCERNS: A 55-year-old man was referred to our gastrointestinal department with complaints of intermittent abdominal pain, distention, diarrhea, and occasional melena that persisted for 2 months. He has a history of nasopharyngeal carcinoma. DIAGNOSES: Intensive, translucent, grape-like cystoids of the whole colon and small intestine were disguised as PCI upon colonoscopy and capsule endoscopy. INTERVENTIONS: Right hemicolectomy and ileocecectomy were performed for intussusception and to confirm the diagnosis. Final pathology indicated that the mass was mantle cell lymphoma. OUTCOMES: After surgery and subsequent chemotherapy, the patient showed good recovery and no abnormal lesions were detected on colonoscopy. LESSONS: As shown through this case and a literature review of similar cases of apparent PCI that was definitively diagnosed as gastrointestinal neoplasm, gastrointestinal malignant neoplasms might rarely present as PCI and neoplastic etiologies should also be considered once PCI is detected. Because most patients with malignant PCIs might inevitably experience severe complications, abdominal surgery should be considered and applied timely after unsuccessful resolution by conservative medical therapies and symptomatic treatments.
[Mh] Termos MeSH primário: Neoplasias Gastrointestinais/diagnóstico
Linfoma de Célula do Manto/diagnóstico
Pneumatose Cistoide Intestinal/diagnóstico
[Mh] Termos MeSH secundário: Endoscopia por Cápsula
Colonoscopia
Diagnóstico Diferencial
Feminino
Neoplasias Gastrointestinais/patologia
Seres Humanos
Linfoma de Célula do Manto/patologia
Meia-Idade
Pneumatose Cistoide Intestinal/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009410


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[PMID]:29069003
[Au] Autor:Chen HB; Lian-Xiang P; Yue H; Chun H; Shu-Ping X; Rong-Pang L; Xiao-Zong W; Xiao-Lin L
[Ad] Endereço:aDepartment of Gastroenterology, Sanming First Hospital Affiliated to Fujian Medical University, Sanming bDepartment of Gastroenterology, Fujian Medical University Union Hospital, Fuzou cDepartment of Cardiology, Fu Wai Hospital of Chinese Academy of Medical Sciences of Peking Union Medical College, Peking, China.
[Ti] Título:Randomized controlled trial of 3 days fasting and oral senna, combined with mannitol and simethicone, before capsule endoscopy.
[So] Source:Medicine (Baltimore);96(43):e8322, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND STUDY AIMS: The approach to small bowel preparation before capsule endoscopy (CE) is still suboptimal. PATIENTS AND METHODS: One hundred eighty patients were randomly allocated to 3 groups. Patients in Group A took 250 mL 20% mannitol and 1 L 0.9% saline orally at 05:00 hours on the day of the procedure. In Group B the same preparation was taken at 20:00 on the day before, and at 05:00 on the day of CE; in addition, 20 mL oral simethicone was taken 30 minutes before CE. Group C was treated identically to Group B, except that the patients fasted for 3 days and took 3 g senna orally 3 times daily before CE. The length of bowel containing green luminal contents was assessed by ImageJ software and bowel cleanliness was evaluated by computed assessment of the cleansing score. RESULTS: Cleansing of the whole small bowel and the distal small bowel were significantly different between the 3 groups (χ = 22.470, P = .000; χ = 17.029, P = .000, respectively). There were also significant differences between the 3 groups in the length of small bowel and specifically the length of the distal small bowel containing green luminal contents (χ = 12.390, P = .000, χ = 15.141, P = .000, respectively), but not with regard to the proximal small bowel (χ = 0.678, P = .509). CONCLUSIONS: Three days fasting and oral senna, combined with 20% mannitol and simethicone, before CE, can reduce the effects of bile on the small bowel and improve small bowel cleansing, especially in the distal small intestine.
[Mh] Termos MeSH primário: Endoscopia por Cápsula
Catárticos/administração & dosagem
Intestino Delgado
Manitol/administração & dosagem
Extrato de Sena/administração & dosagem
Simeticone/administração & dosagem
[Mh] Termos MeSH secundário: Administração Oral
Adulto
Idoso
Endoscopia por Cápsula/efeitos adversos
Endoscopia por Cápsula/métodos
Esquema de Medicação
Jejum
Feminino
Gastroenteropatias/diagnóstico
Seres Humanos
Intestino Delgado/efeitos dos fármacos
Intestino Delgado/fisiopatologia
Masculino
Meia-Idade
Planejamento de Assistência ao Paciente
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Cathartics); 3OWL53L36A (Mannitol); 8013-11-4 (Senna Extract); 8050-81-5 (Simethicone)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171123
[Lr] Data última revisão:
171123
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008322


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[PMID]:28957388
[Au] Autor:von Volkmann HL; Brønstad I; Gilja OH; R Tronstad R; Sangnes DA; Nortvedt R; Hausken T; Dimcevski G; Fiskerstrand T; Nylund K
[Ad] Endereço:National Centre for Ultrasound in Gastroenterology, Haukeland University Hospital, Bergen, Norway.
[Ti] Título:Prolonged intestinal transit and diarrhea in patients with an activating GUCY2C mutation.
[So] Source:PLoS One;12(9):e0185496, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Increased intestinal hydration by activation of the epithelial enzyme linked receptor guanylate cyclase C (GC-C) is a pharmacological principle for treating constipation. Activating mutations in the GUCY2C gene encoding GC-C cause Familial GUCY2C diarrhea syndrome (FGDS) which has been diagnosed with severe dysmotility. AIM: To investigate gut motility and hormones before and after a meal in FGDS patients and compare with healthy controls (HC). SUBJECTS AND METHODS: Bristol stool chart and stool frequency was assessed. Before and after a meal occlusive and non-occlusive contractions were obtained using ultrasound. A wireless motility capsule (WMC) recorded gut transit time, pH, contractions and pressure. Plasma levels of selected gut hormones were measured at different time points. RESULTS: The FGDS patients had 4 (range 1-10) loose stools/day and prolonged total gut transit time compared to HC, 55.5 h vs 28.5 h, respectively,with significantly increased colon transit time. In FGDS patients, pH in duodenum, small bowel and colon was increased and the number of contractions and the intraluminal pressure were significantly decreased, measured by WMC. Ultrasound showed in small bowel increased number of non-occlusive contractions in the FGDS patients. Serotonin (5-HT) plasma levels in the HC peaked 30 min after the meal, while the FGDS patients had no response. CONCLUSION: Despite having diarrhea, the FGDS patients have prolonged transit time through the gut compared to HC, particularly in colon. The reduced number of intestinal contractions and lack of 5-HT release after a meal in FGDS patients surprisingly resemble colonic motility disturbances seen in patients with constipation.
[Mh] Termos MeSH primário: Diarreia/genética
Diarreia/fisiopatologia
Trânsito Gastrointestinal/fisiologia
Mutação/genética
Receptores Acoplados a Guanilato Ciclase/genética
Receptores de Peptídeos/genética
[Mh] Termos MeSH secundário: Adulto
Idoso
Líquidos Corporais
Endoscopia por Cápsula
Diarreia/sangue
Diarreia/diagnóstico por imagem
Feminino
Hormônios/sangue
Seres Humanos
Concentração de Íons de Hidrogênio
Intestinos/patologia
Intestinos/fisiopatologia
Masculino
Meia-Idade
Contração Muscular
Variações Dependentes do Observador
Pressão
Receptores de Enterotoxina
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hormones); 0 (Receptors, Peptide); EC 4.6.1.2 (GUCY2C protein, human); EC 4.6.1.2 (Receptors, Enterotoxin); EC 4.6.1.2 (Receptors, Guanylate Cyclase-Coupled)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170929
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185496


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[PMID]:28917455
[Au] Autor:Bissonnette R; Tamaz R; Bolduc C; Maari C; Robillard C; Nigen S; Delorme I; Lynde C
[Ad] Endereço:Innovaderm Research, Hôpital du Sacre-Coeur de Montréal, Montréal, Ontario, Canada. Electronic address: Rbissonnette@innovaderm.ca.
[Ti] Título:Use of capsule endoscopy to identify lesions suggestive of Crohn's disease in patients with moderate to severe psoriasis.
[So] Source:J Am Acad Dermatol;77(4):755-756, 2017 10.
[Is] ISSN:1097-6787
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Adalimumab/uso terapêutico
Endoscopia por Cápsula/métodos
Doença de Crohn/diagnóstico
Doença de Crohn/epidemiologia
Mucosa Intestinal/efeitos dos fármacos
Psoríase/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Comorbidade
Doença de Crohn/tratamento farmacológico
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Psoríase/diagnóstico
Psoríase/tratamento farmacológico
Medição de Risco
Índice de Gravidade de Doença
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; LETTER
[Nm] Nome de substância:
FYS6T7F842 (Adalimumab)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170918
[St] Status:MEDLINE


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[PMID]:28826553
[Au] Autor:Van de Bruaene C; Hindryckx P; De Looze D
[Ad] Endereço:Department of Gastroenterology, Ghent University Hospital, Ghent, Belgium.
[Ti] Título:Capsule endoscopy in obscure GI bleeding: better to be negative, but let us not be too positive.
[So] Source:Gastrointest Endosc;86(3):574-575, 2017 09.
[Is] ISSN:1097-6779
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Endoscopia por Cápsula
Hemorragia Gastrointestinal
[Mh] Termos MeSH secundário: Endoscopia Gastrointestinal
Seres Humanos
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE


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[PMID]:28826552
[Au] Autor:Kopylov U; Yung DE; Koulaouzidis A; Eliakim R
[Ad] Endereço:Department of Gastroenterology, Sheba Medical Center, Ramat Gan, Israel; Sackler Medical School, Tel Aviv University, Tel Aviv, Israel.
[Ti] Título:Retention rate in small-bowel capsule endoscopy.
[So] Source:Gastrointest Endosc;86(3):573, 2017 09.
[Is] ISSN:1097-6779
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Endoscopia por Cápsula
Intestino Delgado
[Mh] Termos MeSH secundário: Cápsulas Endoscópicas
Seres Humanos
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE


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[PMID]:28816962
[Au] Autor:He C; Zhang J; Chen Z; Feng X; Luo Z; Wan T; Li A; Liu S; Ren Y
[Ad] Endereço:Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
[Ti] Título:Relationships of capsule endoscopy Lewis score with clinical disease activity indices, C-reactive protein, and small bowel transit time in pediatric and adult patients with small bowel Crohn's disease.
[So] Source:Medicine (Baltimore);96(33):e7780, 2017 Aug.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Relationships between the capsule endoscopy Lewis score (LS) and clinical disease activity indices and C-reactive protein (CRP) are controversial in adult patients with Crohn's disease (CD). Also, data on pediatric patients are relatively less. However, correlation between LS and small bowel transit time (SBTT) remains investigational. The aim of the present study was to explore the correlations between LS and clinical disease activity indices, CRP, SBTT in pediatric, and adult patients with small bowel CD.Retrospective, single-center study on consecutive inpatients with established small bowel CD was conducted. The clinical disease activity index was determined using the abbreviated Pediatric Crohn's Disease Activity Index (aPCDAI) in patients aged <18 years and the Harvey-Bradshaw Simple Index (HBI) in adults. Spearman's rank correlation coefficient was used to assess the correlations of LS with aPCDAI, HBI, CRP, and SBTT, respectively.150 patients were enrolled (30 children and adolescents). In pediatric patients, correlations between LS and aPCDAI, CRP were moderate (r1 = 0.413; r2 = 0.379; P1 = .023; P2 = .044). There was no correlation between LS and SBTT (r = -0.029; P = .88). In adults, weak correlations were found between LS and HBI, SBTT (r1 = 0.213; r2 = 0.237; P1 = .019; P2 = .009). Correlation between LS and CRP was moderate (r = 0.326; P < .001). Strong correlations were found between CRP and HBI, aPCDAI (r1 = 0.522; r2 = 0.650; P < .001). The follow-up patients were all in clinical remission after treatment within 4 months, whereas only a minority reached mucosal healing. HBI, aPCDAI, CRP, and LS in all patients were reduced after treatment, whereas difference in CRP in pediatric patients and difference in LS in adults between baseline and follow-up were not found to be statistically significant. Also, the average SBTT at baseline was not found to be different from that at follow-up in all patients.The role of capsule endoscopy should be emphasized both in pediatric and adult patients with small bowel CD. Furthermore, the small bowel transit time may not be affected by the grade of small intestinal inflammation.
[Mh] Termos MeSH primário: Endoscopia por Cápsula/métodos
Doença de Crohn/patologia
Trânsito Gastrointestinal
Índice de Gravidade de Doença
[Mh] Termos MeSH secundário: Adolescente
Adulto
Biomarcadores
Proteína C-Reativa/análise
Criança
China
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Biomarkers); 9007-41-4 (C-Reactive Protein)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007780



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