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  1 / 1600 MEDLINE  
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[PMID]:29338058
[Au] Autor:Khalis M; Charbotel B; Chajès V; Rinaldi S; Moskal A; Biessy C; Dossus L; Huybrechts I; Fort E; Mellas N; Elfakir S; Charaka H; Nejjari C; Romieu I; El Rhazi K
[Ad] Endereço:Department of Epidemiology, Faculty of Medicine and Pharmacy, Fez, Morocco.
[Ti] Título:Menstrual and reproductive factors and risk of breast cancer: A case-control study in the Fez region, Morocco.
[So] Source:PLoS One;13(1):e0191333, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Breast cancer is the most common cancer in women worldwide. In the Moroccan context, the role of well-known reproductive factors in breast cancer remains poorly documented. The aim of this study was to explore the relationship between menstrual and reproductive factors and breast cancer risk in Moroccan women in the Fez region. METHODS: A case-control study was conducted at the Hassan II University Hospital of Fez between January 2014 and April 2015. A total of 237 cases of breast cancer and 237 age-matched controls were included. Information on sociodemographic characteristics, menstrual and reproductive history, family history of breast cancer, and lifestyle factors was obtained through a structured questionnaire. Conditional logistic regression models were used to estimate odds ratios and 95% confidence intervals for breast cancer by menstrual and reproductive factors adjusted for potential confounders. RESULTS: Early menarche (OR = 1.60, 95% CI: 1.08-2.38) and nulliparity (OR = 3.77, 95% CI: 1.98-7.30) were significantly related to an increased risk of breast cancer, whereas an early age at first full-term pregnancy was associated with a decreased risk of breast cancer (OR = 0.41, 95% CI: 0.25-0.65). CONCLUSION: The results of this study confirm the role of established reproductive factors for breast cancer in Moroccan women. It identified some susceptible groups at high risk of breast cancer. Preventive interventions and screening should focus on these groups as a priority. These results should be confirmed in a larger, multicenter study.
[Mh] Termos MeSH primário: Neoplasias da Mama/epidemiologia
Menstruação
[Mh] Termos MeSH secundário: Adulto
Neoplasias da Mama/fisiopatologia
Estudos de Casos e Controles
Feminino
Seres Humanos
Meia-Idade
Marrocos/epidemiologia
História Reprodutiva
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191333


  2 / 1600 MEDLINE  
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[PMID]:28886034
[Au] Autor:Mekango DE; Alemayehu M; Gebregergs GB; Medhanyie AA; Goba G
[Ad] Endereço:Wachemo University, College of Medicine and Health Sciences, Department of Public Health, Hosanna, Ethiopia.
[Ti] Título:Determinants of maternal near miss among women in public hospital maternity wards in Northern Ethiopia: A facility based case-control study.
[So] Source:PLoS One;12(9):e0183886, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In Ethiopia, 20,000 women die each year from complications related to pregnancy, childbirth and post-partum. For every woman that dies, 20 more experience injury, infection, disease, or disability. "Maternal near miss" (MNM), defined by the World Health Organization (WHO) as a woman who nearly dies, but survives a complication during pregnancy, childbirth or within 42 days of a termination, is a proxy indicator of maternal mortality and quality of obstetric care. In Ethiopia, few studies have examined MNM. This study aims to identify determinants of MNM among a small population of women in Tigray, Ethiopia. METHODS: Unmatched case-control study was conducted in hospitals in Tigray Region, Northern Ethiopia, from January 30-March 30, 2016. The sample included 103 cases and 205 controls recruited from among women seeking obstetric care at six (6) public hospitals. Clients with life-threatening obstetric complications, including hemorrhage, hypertensive diseases of pregnancy, dystocia, infection, and anemia or clinical signs of severe anemia (in women without hemorrhage) were taken as cases and those with normal obstetric outcomes were controls. Cases were selected based on proportion to size allocation while systematic sampling was employed for controls. Binary and multiple variable logistic regression ("odds ratio") analyses were calculated at 95% CI. RESULTS: Roughly 90% of cases and controls were married and 25% experienced their first pregnancy before the age of 16 years. About two-thirds of controls and 45.6% of cases had gestational ages between 37-41 weeks. Among cases, severe obstetric hemorrhage (44.7%), hypertensive disorders (38.8%), dystocia (17.5%), sepsis (9.7%) and severe anemia (2.9%) were leading causes of MNM. Histories of chronic maternal medical problems like hypertension, diabetes were reported in 55.3% of cases and 33.2% of controls. Women with no formal education [AOR = 3.2;95%CI:1.24, 8.12], being less than 16 years of age at first pregnancy [AOR = 2.5;95%CI:1.12,5.63], induced labor[AOR = 3.0; 95%CI:1.44, 6.17], history of cesarean section[AOR = 4.6; 95% CI: 1.98, 7.61] or chronic medical disorder[AOR = 3.5;95%CI:1.78, 6.93], and women who traveled more than 60 minutes before reaching their final place of care[AOR = 2.8;95% CI: 1.19,6.35] had higher odds of experiencing MNM. CONCLUSIONS: Macro-developments like increasing road and health facility access as well as expanding education will all help reduce MNM. Work should be continued to educate women and providers about common predictors of MNM like history of C-section and chronic illness as well as teenage pregnancy. These efforts should be carried out at the facility, community, and individual levels. Targeted follow-up with women with history of chronic disease and C-section could also help reduce MNM.
[Mh] Termos MeSH primário: Hospitais Públicos
Período Pós-Parto
Complicações na Gravidez/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Comorbidade
Etiópia/epidemiologia
Feminino
Maternidades
Seres Humanos
Mortalidade Materna
Gravidez
Complicações na Gravidez/mortalidade
História Reprodutiva
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183886


  3 / 1600 MEDLINE  
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[PMID]:28859327
[Au] Autor:Alpizar-Rodriguez D; Mueller RB; Möller B; Dudler J; Ciurea A; Zufferey P; Kyburz D; Walker UA; von Mühlenen I; Roux-Lombard P; Mahler M; Lamacchia C; Courvoisier DS; Gabay C; Finckh A
[Ad] Endereço:Division of Rheumatology, Department of Internal Medicine Specialties, University Hospitals of Geneva, Geneva.
[Ti] Título:Female hormonal factors and the development of anti-citrullinated protein antibodies in women at risk of rheumatoid arthritis.
[So] Source:Rheumatology (Oxford);56(9):1579-1585, 2017 Sep 01.
[Is] ISSN:1462-0332
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objectives: To analyse the association between female hormonal factors and the development of systemic autoimmunity associated with RA in women at increased risk for RA, namely first-degree relatives of patients with RA (RA-FDRs). Methods: In an ongoing cohort study of RA-FDRs, we analysed all women with available ACPA status. The primary outcome was ACPA positivity. The predictors of interest were female hormonal factors, such as oral contraceptives, breastfeeding, post-menopausal status, early post-menopausal period and total number of ovulatory years. Results: A total of 768 female RA-FDRs were analysed, of which 42 (5%) had developed ACPA positivity. ACPA-positive women were older (52 vs 44 years, P = 0.001). Hormonal factors significantly and independently associated with the presence of ACPA were the post-menopausal (P < 0.001) and the early post-menopausal periods (P = 0.040). Conclusions: In women at increased risk of RA, characteristic systemic autoimmunity was associated with menopause, suggesting that the acute decline in ovarian function might contribute to the development of autoimmunity associated with RA and potentially to the increased risk of RA in women.
[Mh] Termos MeSH primário: Artrite Reumatoide/imunologia
Autoanticorpos/sangue
Peptídeos Cíclicos/imunologia
História Reprodutiva
[Mh] Termos MeSH secundário: Adulto
Autoimunidade
Estudos de Coortes
Feminino
Seres Humanos
Masculino
Meia-Idade
Paridade
Pós-Menopausa/imunologia
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Autoantibodies); 0 (Peptides, Cyclic); 0 (cyclic citrullinated peptide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170902
[St] Status:MEDLINE
[do] DOI:10.1093/rheumatology/kex239


  4 / 1600 MEDLINE  
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[PMID]:28799272
[Au] Autor:Wilson MSJ; Powell-Bowns M; Robertson AG; Luhmann A; Richards CH; Scottish Surgical Research Group
[Ad] Endereço:Department of General Surgery, NHS Tayside, Ninewells Hospital, Dundee, UK.
[Ti] Título:Results of a national multicenter audit assessment of gynecologic history in surgical patients.
[So] Source:Int J Gynaecol Obstet;139(2):197-201, 2017 Nov.
[Is] ISSN:1879-3479
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To determine the adequacy of assessing gynecologic history for females of reproductive age (FRA) admitted to a general surgery department. METHODS: The present prospective multicenter audit included FRA who were admitted for elective or emergency procedures to general surgery departments in Scotland between May 11 and May 25, 2015. Data were compared between patients who were admitted for elective and emergency treatment. RESULTS: There were 530 FRA included from 18 centers, including 169 (31.9%) and 361 (68.1%) elective and emergency admissions, respectively. The date of last menstrual period was document for 203 (38.3%) patients, use of contraception for 149 (28.1%), sexual activity for 83 (15.7%), pregnancy status for 274 (51.7%), and the possibility of pregnancy for 237 (44.7%). A higher incidence of documented date of last menstrual period (P=0.002) and pregnancy status (P<0.001) were identified among emergency admissions, and the possibility of pregnancy was documented more commonly among elective admissions (P<0.001). CONCLUSIONS: Key factors required for gynecologic assessment were often not documented for FRA admitted to general surgery both as elective and emergency admissions. Surgical teams and medical undergraduates require educating regarding the importance of obtaining gynecologic history for all FRA.
[Mh] Termos MeSH primário: Auditoria Médica
Avaliação de Resultados (Cuidados de Saúde)
Admissão do Paciente
Medição de Risco
Procedimentos Cirúrgicos Operatórios/normas
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Gravidez
Testes de Gravidez
Estudos Prospectivos
História Reprodutiva
Escócia
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170812
[St] Status:MEDLINE
[do] DOI:10.1002/ijgo.12296


  5 / 1600 MEDLINE  
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[PMID]:28719794
[Au] Autor:Dung Yun Trieu P; Mello-Thoms C; Peat JK; Doan Do T; Brennan PC
[Ad] Endereço:1 The University of Sydney, Lidcombe, New South Wales, Australia.
[Ti] Título:Associations of Breast Density With Demographic, Reproductive, and Lifestyle Factors in a Developing Southeast Asian Population.
[So] Source:Asia Pac J Public Health;29(5):377-387, 2017 Jul.
[Is] ISSN:1941-2479
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to investigate how breast density interacted with demographic, reproductive, and lifestyle features among Vietnamese women. Mammographic density and established risk factors for breast cancer were collected from 1651 women (345 cancer cases and 1306 normal cases) in Vietnam. The association of breast density categories with potential risk factors was investigated using Spearman's test for continuous variables and χ tests for categorical variables. Independent factors associated with high breast density and breast cancer in specific density groupings were assessed using logistic regression. Results showed that high breast density was significantly associated with young age, low body mass index, low number of children, early age at having the last child, premenopausal status, and increased vegetable consumption. Reproductive factors were key agents associated with breast cancer for women with high breast density, which was not so evident for women with low breast density.
[Mh] Termos MeSH primário: Densidade da Mama
Neoplasias da Mama/epidemiologia
Estilo de Vida
História Reprodutiva
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Estudos de Casos e Controles
Feminino
Seres Humanos
Mamografia
Meia-Idade
Estudos Prospectivos
Fatores de Risco
Vietnã/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.1177/1010539517717313


  6 / 1600 MEDLINE  
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[PMID]:28521890
[Au] Autor:Hall PS; Nah G; Howard BV; Lewis CE; Allison MA; Sarto GE; Waring ME; Jacobson LT; Manson JE; Klein L; Parikh NI
[Ad] Endereço:Division of Cardiology, University of California, San Francisco, San Francisco, California.
[Ti] Título:Reproductive Factors and Incidence of Heart Failure Hospitalization in the Women's Health Initiative.
[So] Source:J Am Coll Cardiol;69(20):2517-2526, 2017 May 23.
[Is] ISSN:1558-3597
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Reproductive factors reflective of endogenous sex hormone exposure might have an effect on cardiac remodeling and the development of heart failure (HF). OBJECTIVES: This study examined the association between key reproductive factors and the incidence of HF. METHODS: Women from a cohort of the Women's Health Initiative were systematically evaluated for the incidence of HF hospitalization from study enrollment through 2014. Reproductive factors (number of live births, age at first pregnancy, and total reproductive duration [time from menarche to menopause]) were self-reported at study baseline in 1993 to 1998. We employed Cox proportional hazards regression analysis in age- and multivariable-adjusted models. RESULTS: Among 28,516 women, with an average age of 62.7 ± 7.1 years at baseline, 1,494 (5.2%) had an adjudicated incident HF hospitalization during an average follow-up of 13.1 years. After adjusting for covariates, total reproductive duration in years was inversely associated with incident HF: hazard ratios (HRs) of 0.99 per year (95% confidence interval [CI]: 0.98 to 0.99 per year) and 0.95 per 5 years (95% CI: 0.91 to 0.99 per 5 years). Conversely, early age at first pregnancy and nulliparity were significantly associated with incident HF in age-adjusted models, but not after multivariable adjustment. Notably, nulliparity was associated with incident HF with preserved ejection fraction in the fully adjusted model (HR: 2.75; 95% CI: 1.16 to 6.52). CONCLUSIONS: In post-menopausal women, shorter total reproductive duration was associated with higher risk of incident HF, and nulliparity was associated with higher risk for incident HF with preserved ejection fraction. Whether exposure to endogenous sex hormones underlies this relationship should be investigated in future studies.
[Mh] Termos MeSH primário: Insuficiência Cardíaca
Hospitalização/estatística & dados numéricos
História Reprodutiva
Remodelação Ventricular/fisiologia
[Mh] Termos MeSH secundário: Idoso
Estudos de Coortes
Feminino
Hormônios Esteroides Gonadais/metabolismo
Insuficiência Cardíaca/diagnóstico
Insuficiência Cardíaca/epidemiologia
Insuficiência Cardíaca/metabolismo
Seres Humanos
Incidência
Menarca/metabolismo
Meia-Idade
Pós-Menopausa/metabolismo
Fatores de Risco
Estatística como Assunto
Volume Sistólico/fisiologia
Estados Unidos/epidemiologia
Saúde da Mulher
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gonadal Steroid Hormones)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170520
[St] Status:MEDLINE


  7 / 1600 MEDLINE  
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[PMID]:28441434
[Au] Autor:Brady E; Hill K
[Ad] Endereço:Johns Hopkins School of Public Health, Baltimore, Maryland, United States of America.
[Ti] Título:Testing survey-based methods for rapid monitoring of child mortality, with implications for summary birth history data.
[So] Source:PLoS One;12(4):e0176366, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Under-five mortality estimates are increasingly used in low and middle income countries to target interventions and measure performance against global development goals. Two new methods to rapidly estimate under-5 mortality based on Summary Birth Histories (SBH) were described in a previous paper and tested with data available. This analysis tests the methods using data appropriate to each method from 5 countries that lack vital registration systems. SBH data are collected across many countries through censuses and surveys, and indirect methods often rely upon their quality to estimate mortality rates. METHODS AND FINDINGS: The Birth History Imputation method imputes data from a recent Full Birth History (FBH) onto the birth, death and age distribution of the SBH to produce estimates based on the resulting distribution of child mortality. DHS FBHs and MICS SBHs are used for all five countries. In the implementation, 43 of 70 estimates are within 20% of validation estimates (61%). Mean Absolute Relative Error is 17.7.%. 1 of 7 countries produces acceptable estimates. The Cohort Change method considers the differences in births and deaths between repeated Summary Birth Histories at 1 or 2-year intervals to estimate the mortality rate in that period. SBHs are taken from Brazil's PNAD Surveys 2004-2011 and validated against IGME estimates. 2 of 10 estimates are within 10% of validation estimates. Mean absolute relative error is greater than 100%. CONCLUSIONS: Appropriate testing of these new methods demonstrates that they do not produce sufficiently good estimates based on the data available. We conclude this is due to the poor quality of most SBH data included in the study. This has wider implications for the next round of censuses and future household surveys across many low- and middle- income countries.
[Mh] Termos MeSH primário: Mortalidade da Criança
Inquéritos Epidemiológicos
[Mh] Termos MeSH secundário: Distribuição por Idade
Criança
Países em Desenvolvimento
Feminino
Seres Humanos
Masculino
História Reprodutiva
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170426
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0176366


  8 / 1600 MEDLINE  
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[PMID]:28440542
[Au] Autor:Ben Khedher S; Neri M; Papadopoulos A; Christiani DC; Diao N; Harris CC; Olivo-Marston S; Schwartz AG; Cote M; Koushik A; Siemiatycki J; Landi MT; Hung RJ; McLaughlin J; Duell EJ; Andrew AS; Orlow I; Park BJ; Brenner H; Saum KU; Pesatori AC; Stücker I
[Ad] Endereço:Université Paris Saclay, Université Paris Sud, UVSQ, CESP, INSERM, Villejuif, France.
[Ti] Título:Menstrual and reproductive factors and lung cancer risk: A pooled analysis from the international lung cancer consortium.
[So] Source:Int J Cancer;141(2):309-323, 2017 Jul 15.
[Is] ISSN:1097-0215
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Many clinical features of lung cancer are different in women and men. Sex steroid hormones exert effects in nonreproductive organs, such as the lungs. The association between menstrual and childbearing factors and the risk of lung cancer among women is still debated. We performed a pooled analysis of eight studies contributing to the International Lung Cancer Consortium (4,386 cases and 4,177 controls). Pooled associations between menstrual or reproductive factors and lung cancer were estimated using multivariable unconditional logistic regression. Subgroup analyses were done for menopause status, smoking habits and histology. We found no strong support for an association of age at menarche and at menopause with lung cancer, but peri/postmenopausal women were at higher risk compared to premenopausal (OR 1.47, 95% CI 1.11-1.93). Premenopausal women showed increased risks associated with parity (OR 1.74, 95% CI 1.03-2.93) and number of children (OR 2.88, 95% CI 1.21-6.93 for more than 3 children; p for trend 0.01) and decreased with breastfeeding (OR 0.54, 95% CI 0.30-0.98). In contrast, peri/postmenopausal subjects had ORs around unity for the same exposures. No major effect modification was exerted by smoking status or cancer histology. Menstrual and reproductive factors may play a role in the genesis of lung cancer, yet the mechanisms are unclear, and smoking remains the most important modifiable risk factor. More investigations in large well-designed studies are needed to confirm these findings and to clarify the underlying mechanisms of gender differences in lung cancer risk.
[Mh] Termos MeSH primário: Neoplasias Pulmonares/epidemiologia
Menstruação
História Reprodutiva
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Estudos de Casos e Controles
Feminino
Seres Humanos
Modelos Logísticos
Menarca
Menopausa
Meia-Idade
Pré-Menopausa
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170426
[St] Status:MEDLINE
[do] DOI:10.1002/ijc.30750


  9 / 1600 MEDLINE  
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[PMID]:28426980
[Au] Autor:Cordina-Duverger E; Leux C; Neri M; Tcheandjieu C; Guizard AV; Schvartz C; Truong T; Guénel P
[Ad] Endereço:CESP (Center for Research in Epidemiology and Population Health), INSERM U1018, Cancer and Environment Team, Université Paris-Saclay, Université Paris-Sud, Villejuif, France.
[Ti] Título:Hormonal and reproductive risk factors of papillary thyroid cancer: A population-based case-control study in France.
[So] Source:Cancer Epidemiol;48:78-84, 2017 Jun.
[Is] ISSN:1877-783X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The three times higher incidence of thyroid cancer in women compared to men points to a role of female sex hormones in its etiology. However the effects of these factors are poorly understood. We analyzed the association between thyroid cancer and hormonal and reproductive factors among women enrolled in CATHY, a population-based case-control study conducted in France. The study included 430 cases of papillary thyroid cancer and 505 controls frequency-matched on age and area of residence. The odds ratios for thyroid cancer increased with age at menarche (p trend 0.05). Postmenopausal women were at increased risk, as compared to premenopausal women, particularly if menopause followed an ovariectomy, and for women with age at menopause <55years. In addition, use of oral contraceptives and menopausal hormone therapy reduced the association with thyroid cancer by about one third, and breastfeeding by 27%. Overall, these findings provide evidence that the risk of thyroid cancer increases with later age at menarche and after menopause, and decreases with use of oral contraceptives and menopausal hormone therapy. These findings confirm an implication of hormonal factors in papillary thyroid cancer risk, whose mechanisms need to be elucidated.
[Mh] Termos MeSH primário: Carcinoma Papilar/complicações
Terapia de Reposição Hormonal/métodos
Neoplasias da Glândula Tireoide/complicações
[Mh] Termos MeSH secundário: Adulto
Idoso
Estudos de Casos e Controles
Feminino
França
Seres Humanos
Meia-Idade
História Reprodutiva
Projetos de Pesquisa
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170421
[St] Status:MEDLINE


  10 / 1600 MEDLINE  
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[PMID]:28415992
[Au] Autor:Stücker I; Martin D; Neri M; Laurent-Puig P; Blons H; Antoine M; Guiochon-Mantel A; Brailly-Tabard S; Canonico M; Wislez M; Trédaniel J; WELCA study group
[Ad] Endereço:Université Paris-Saclay, Univ. Paris-Sud, UVSQ, CESP, Inserm UMRS1018, 94807, Villejuif, France. isabelle.stucker@inserm.fr.
[Ti] Título:Women Epidemiology Lung Cancer (WELCA) study: reproductive, hormonal, occupational risk factors and biobank.
[So] Source:BMC Public Health;17(1):324, 2017 Apr 17.
[Is] ISSN:1471-2458
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Lung cancer aetiology and clinical aspects have been mainly studied in men, although specific risk factors probably exist in women. Here we present the rationale, design and organization of the WELCA study (Women Epidemiology Lung CAncer) that has been launched to investigate lung cancer in women, focusing particularly on hormonal and occupational factors. METHODS/DESIGN: WELCA is a population based case-control study and planned to recruit 1000 cases and 1000 controls in three years, based on study power calculation. Eligible cases are female patients newly diagnosed with lung cancer, living in Paris and the Ile de France area and aged up to 75 years. Almost all Parisian pneumology and oncology clinical departments are involved. The control group is a random sample of the population living in the same area, frequency-matched on age and additionally stratified on the distribution of socio-professional categories of women residing there. After acquisition of written consent, research nurses administer standardized computer assisted questionnaires to all the subjects in face-to-face interviews and acquire anthropometric measures. Besides usual socio-demographic characteristics, information is gathered about menstrual and reproductive factors, hormonal treatments, lifestyle and leisure characteristics, occupational history, personal and familial medical history. Biological samples are also collected, in order to establish a biobank for molecular epidemiology studies. Molecular characteristics of the tumours will be obtained and patients will be followed up for five years. DISCUSSION: The WELCA study aims to answer key questions in lung cancer aetiology and clinical characteristics specifically in women. The role of hormonal impregnation is investigated, and the interactions with cigarette smoking or body mass index (BMI) will be analyzed in detail. The occupational history of the subjects is carefully reconstructed, focusing in particular on the service sector. The creation of a biobank for collection of serum, plasma, DNA and tumour tissue will allow the genetic and biochemical characterization of both the subjets and the tumours. The follow-up of the patients will help in disentangling the role of hormonal factors and tumour molecular characteristics in survival.
[Mh] Termos MeSH primário: Bancos de Espécimes Biológicos
Terapia de Reposição Hormonal/efeitos adversos
Neoplasias Pulmonares/epidemiologia
Neoplasias Pulmonares/etiologia
Exposição Ocupacional/efeitos adversos
História Reprodutiva
Saúde da Mulher
[Mh] Termos MeSH secundário: Adulto
Idoso
Índice de Massa Corporal
Estudos de Casos e Controles
Feminino
Seguimentos
França/epidemiologia
Seres Humanos
Meia-Idade
Doenças Profissionais/epidemiologia
Doenças Profissionais/etiologia
Paris/epidemiologia
Fatores de Risco
Fumar/epidemiologia
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170727
[Lr] Data última revisão:
170727
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE
[do] DOI:10.1186/s12889-017-4191-1



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