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[PMID]: 28453783 [Au] Autor: Ferré Á; Poca MA; de la Calzada MD; Moncho D; Romero O; Sampol G; Sahuquillo J [Ad] Endereço: Clinical Neurophysiology Department, Barcelona, Spain. [Ti] Título: Sleep-Related Breathing Disorders in Chiari Malformation Type 1: A Prospective Study of 90 Patients. [So] Source: Sleep;40(6), 2017 Jun 01. [Is] ISSN: 1550-9109 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Study objective: The aim of the present study is to describe the prevalence of sleep disorders in a large group of patients with Chiari malformation type 1 (CM-1) and determine the presence of risk factors associated with these abnormalities. Methods: Prospective study with consecutive patient selection. We included 90 adult patients with CM-1, defined by the presence of a cerebellar tonsillar descent (TD) ≥3 mm. Clinical, neuroradiological studies, and nocturnal polysomnography (PSG) was carried out. In addition, patients were also subclassified into 2 CM subtypes: CM-1, with the obex above the foramen magnum (FM) and CM-1.5, in which along with a TD ≥3 mm, the obex was located below the FM. Results: We observed a high prevalence (50%) of sleep-related breathing disorders (SRBDs) with predominant hypopnea. Only six patients showed a central apnea index of ≥5. Hypoventilation was observed in only three patients. SRBD severity was associated with male sex, older age, excess weight, and the presence of hydrocephalus. No differences in clinical or PSG parameters were found when comparing CM subtypes (CM-1 and CM-1.5). Sleep architecture study showed decreased sleep efficiency with an increase in arousal and waking after sleep onset. The presence of SRBDs was found to be associated with poorer sleep architecture parameters. Conclusions: This study confirms a high prevalence of SRBDs in patients with CM-1 and CM-1.5, with a predominant obstructive component. Nocturnal PSG recordings should be systematically conducted in these patients, especially those who are male, older, or overweight or those who present hydrocephalus. [Mh] Termos MeSH primário: Malformação de Arnold-Chiari/epidemiologia Dissonias/epidemiologia Dissonias/fisiopatologia [Mh] Termos MeSH secundário: Adulto Distribuição por Idade Malformação de Arnold-Chiari/classificação Nível de Alerta Feminino Seres Humanos Hidrocefalia/epidemiologia Hipoventilação/epidemiologia Masculino Sobrepeso/epidemiologia Polissonografia Prevalência Estudos Prospectivos Fatores de Risco Caracteres Sexuais Síndromes da Apneia do Sono/epidemiologia Síndromes da Apneia do Sono/fisiopatologia Vigília [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170429 [St] Status: MEDLINE [do] DOI: 10.1093/sleep/zsx069

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[PMID]: 28451755 [Au] Autor: Bosi M; De Vito A; Bellini C; D'Agostino G; Firinu E; Gobbi R; Pacella A; Filograna Pignatelli G; Zeccardo E; Poletti V; Vicini C [Ad] Endereço: Department of Diseases of the Thorax, GB Morgagni-Pierantoni Hospital, AUSL of Romagna, Forlì, Italy. [Ti] Título: The interpretation of compact polysomnography/polygraphy in sleep breathing disorders patients: a validation's study. [So] Source: Eur Arch Otorhinolaryngol;274(8):3251-3257, 2017 Aug. [Is] ISSN: 1434-4726 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: The Otorhinolaryngologist (ENT) frequently has to deal with OSA or suspicious OSA patients and undergone polysomnography (PSG) or portable monitoring (PM) and should be confident about the quality and consistency of the polysomnographic diagnosis. The main polysomnographic traces compressed in a unique epoch, defined as compact PSG/PM (CP), could represent an efficient tool to confirm the quality of PSG/PM Sleep Breathing Disorders diagnosis. This is a validation's study of a CP interpretation's method, analyzing the learning curve, the level of diagnostic accuracy, and the inter-operator agreement in interpreting the CP pattern between a group of ENT specialists not skilled in PSG/PM scoring, but managing SBD patients during daily practice. Seven ENT specialists have been enrolled in the study. 50 CP traces (ranging from normal to all main SBD patterns) have been showed to each participant for the interpretation and scoring process, before and after a 2-h theoretical-practical interactive lesson, focusing on the recognition of the four main oximetric patterns on CP traces (normal, phasic, prolonged, and overlap patterns). RESULTS: before and after the theoretical-practical interactive lesson, the whole diagnostic accuracy in interpreting the 50 CP has been reported improved from 0.12 to 0.80 (median 0.52) to 0.82-0.96 (median 0.92) (p = 0.006) and the inter-scorers' agreement showed a kappa value increased from of 0.18 to 0.75 (p < 0.0001). A complete clinical diagnostic evaluation is essential in OSA patients and the ENT specialist should be concerned to verify if the patient, suitable for surgical therapy, is affected really by an isolated form of OSA. The CP interpretation allows a checking of the proper nosographic SBD framework and could be significantly important for all ENT specialists not skilled in PSG/PM scoring, but managing SBD patients during daily practice. The data reported in our validation's study showed that the CP interpretation's method is easy to apply, with a rapid learning curve. The level of diagnostic accuracy is high with a high inter-scorer agreement in interpreting the CP patterns. [Mh] Termos MeSH primário: Otolaringologia/educação Testes Imediatos/normas Polissonografia Síndromes da Apneia do Sono/diagnóstico [Mh] Termos MeSH secundário: Precisão da Medição Dimensional Feminino Seres Humanos Itália Curva de Aprendizado Masculino Meia-Idade Oximetria/métodos Administração dos Cuidados ao Paciente/métodos Administração dos Cuidados ao Paciente/normas Polissonografia/métodos Polissonografia/normas Desenvolvimento de Pessoal/métodos [Pt] Tipo de publicação: JOURNAL ARTICLE; VALIDATION STUDIES [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180307 [Lr] Data última revisão: 180307 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170429 [St] Status: MEDLINE [do] DOI: 10.1007/s00405-017-4578-8

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[PMID]: 29386443 [Au] Autor: Nakano N; Kinoshita F; Takada H; Nakayama M [Ad] Endereço: Good Sleep Center Nagoya City University Hospital. [Ti] Título: [Electromyography Analysis of Rapid Eye Movement Sleep Behavior Disorder]. [So] Source: Nihon Eiseigaku Zasshi;73(1):27-33, 2018. [Is] ISSN: 1882-6482 [Cp] País de publicação: Japan [La] Idioma: jpn [Ab] Resumo: Polysomnography (PSG), which records physiological phenomena including brain waves, breathing status, and muscle tonus, is useful for the diagnosis of sleep disorders as a gold standard. However, measurement and analysis are complex for several specific sleep disorders, such as rapid eye movement (REM) sleep behavior disorder (RBD). Usually, brain waves during REM sleep indicate an awakening pattern under relaxed conditions of skeletal and antigravity muscles. However, these muscles are activated during REM sleep when patients suffer from RBD. These activated muscle movements during REM, so-called REM without atonia (RWA) recorded by PSG, may be related to a neurodegenerative disease such as Parkinson's disease. Thus, careful analysis of RWA is significant not only physically, but also clinically. Commonly, manual viewing measurement analysis of RWA is time-consuming. Therefore, quantitative studies on RWA are rarely reported. A software program, developed from Microsoft Office Excel , was used to semiautomatically analyze the RWA ratio extracted from PSG to compare with manual viewing measurement analysis. In addition, a quantitative muscle tonus study was carried out to evaluate the effect of medication on RBD patients. Using this new software program, we were able to analyze RWA on the same cases in approximately 15 min as compared with 60 min in the manual viewing measurement analysis. This software program can not only quantify RWA easily but also identify RWA waves for either phasic or tonic bursts. We consider that this software program will support physicians and scientists in their future research on RBD. We are planning to offer this software program for free to physicians and scientists. [Mh] Termos MeSH primário: Eletromiografia/métodos Músculo Esquelético/fisiopatologia Transtorno do Comportamento do Sono REM/diagnóstico Transtorno do Comportamento do Sono REM/fisiopatologia Sono REM/fisiologia [Mh] Termos MeSH secundário: Idoso Feminino Seres Humanos Masculino Tono Muscular Polissonografia Software [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180228 [Lr] Data última revisão: 180228 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180202 [St] Status: MEDLINE [do] DOI: 10.1265/jjh.73.27

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[PMID]: 29370207 [Au] Autor: Tranah GJ; Yaffe K; Nievergelt CM; Parimi N; Glymour MM; Ensrud KE; Cauley JA; Ancoli-Israel S; Mariani S; Redline S; Stone KL; Osteoporotic Fractures in Men Study (MrOS) Research Group [Ad] Endereço: Research Institute, California Pacific Medical Center, San Francisco, California, United States of America. [Ti] Título: APOEε4 and slow wave sleep in older adults. [So] Source: PLoS One;13(1):e0191281, 2018. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Slow wave (or stage N3) sleep has been linked to a variety of cognitive processes. However, the role of stage N3 in the elderly is debated. The link between stage N3 and episodic memory may be weakened or changed in the older adult population, possibly due to several altered mechanisms impacting the cellular structure of the brain. The bases for the age-related dissociation between stage N3 and cognition are not understood. Since APOEε4 status is the strongest genetic risk factor for cognitive decline, we assessed whether the ε4 allele is associated with stage N3 sleep. Participants were from the population-based Osteoporotic Fractures in Men (MrOS) cohort with polysomnography and APOEε4 genotype data (n = 2,302, 100% male, mean age 76.6 years). Sleep stages were objectively measured using overnight in-home polysomnography and central electroencephalogram data were used to score stage N3 sleep. Cognitive function was assessed using the Modified Mini Mental State Exam (3MS). The APOE rs429358 single nucleotide polymorphism, which defines the APOEε4 allele, was genotyped using a custom genotyping array. Total time in stage N3 sleep was significantly higher (p<0.0001) among the 40 MrOS participants carrying two copies of the ε4 allele (62±5.2 minutes) compared with 43±1.5 minutes for carriers of one ε4 allele (n = 515) and 40±0.8 minutes for ε4 non-carriers (n = 1747). All results were independent of sleep efficiency, number of sleep cycles, and apnea hypopnea index. These findings support an association between APOEε4 genotype and sleep stage N3 in the elderly. Increased total stage N3 duration among ε4/ε4 carriers does not appear to reflect compensation for prior cognitive decline and may reflect overactive downscaling of synapses during sleep. If confirmed, these results might in part explain the high risk of age-related cognitive decline and AD among APOE ε4/ε4 carriers. [Mh] Termos MeSH primário: Apolipoproteína E4/genética Sono/genética [Mh] Termos MeSH secundário: Idoso Alelos Técnicas de Genotipagem Seres Humanos Masculino Polissonografia Sono/fisiologia [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Apolipoprotein E4) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180226 [Lr] Data última revisão: 180226 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180126 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0191281

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[PMID]: 29273274 [Au] Autor: Saur JS; Brietzke SE [Ad] Endereço: Walter Reed National Military Medical Center, Bethesda, MD 20889, United States. [Ti] Título: Response to Letter to the Editor regarding article titled "Polysomnography results versus clinical factors to predict postoperative respiratory complications following pediatric adenotonsillectomy". [So] Source: Int J Pediatr Otorhinolaryngol;105:189-190, 2018 02. [Is] ISSN: 1872-8464 [Cp] País de publicação: Ireland [La] Idioma: eng [Mh] Termos MeSH primário: Adenoidectomia Polissonografia [Mh] Termos MeSH secundário: Criança Seres Humanos Complicações Pós-Operatórias Período Pós-Operatório Apneia Obstrutiva do Sono/cirurgia Tonsilectomia [Pt] Tipo de publicação: LETTER; COMMENT [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180226 [Lr] Data última revisão: 180226 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171224 [St] Status: MEDLINE

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[PMID]: 29233563 [Au] Autor: Hsueh WY; Lee CF; Lee CH; Kang KT [Ad] Endereço: Department of Otolaryngology, Hsinchu Cathay General Hospital, Hsinchu, Taiwan; School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Yuanpei University of Medical Technology, Department of Biomedical Engineering, Hsinchu, Taiwan. [Ti] Título: Polysomnography results versus clinical factors to predict post-operative respiratory complications following pediatric adenotonsillectomy. [So] Source: Int J Pediatr Otorhinolaryngol;105:187-188, 2018 02. [Is] ISSN: 1872-8464 [Cp] País de publicação: Ireland [La] Idioma: eng [Mh] Termos MeSH primário: Adenoidectomia Polissonografia [Mh] Termos MeSH secundário: Criança Seres Humanos Complicações Pós-Operatórias Período Pós-Operatório Estudos Retrospectivos Apneia Obstrutiva do Sono/cirurgia Tonsilectomia [Pt] Tipo de publicação: LETTER; COMMENT [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180226 [Lr] Data última revisão: 180226 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171214 [St] Status: MEDLINE

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[PMID]: 29384937 [Au] Autor: Zhang W; Huang Z; Jin Y [Ad] Endereço: Department of Rehabilitation Medicine, Panyu Central Hospital, Guangzhou, China. [Ti] Título: Acupuncture as a primary and independent treatment for a patient with chronic insomnia: One-year follow-up case report. [So] Source: Medicine (Baltimore);96(52):e9471, 2017 Dec. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: RATIONALE: Insomnia is a common disease. Till date, no study has reported the long-term (up to 1 year) outcomes of acupuncture as a primary and independent treatment in patients with insomnia. This report aims to present response of patient who was treated by acupuncture. This patient was evaluated with polysomnography. PATIENT CONCERNS: A 40-year-old patient had been diagnosed with insomnia for 2 years and getting worse since 1 month ago. He had undergone depression and anxiety emotion, but refused to take medical treatment for chronic insomnia. DIAGNOSES: In this study, the diagnosis of chronic insomnia was based on the International Classification of Sleep Disorders insomnia. The patient had no obvious differential diagnosis. INTERVENTIONS: Acupuncture treatment was planned for this patient who refused to take medical treatment with chronic insomnia. So the patient received 1 hour of acupuncture treatment for 12 weeks. OUTCOME: Polysomnographic evaluation was performed at baseline and 3 months, and 1 year after acupuncture treatment. He was asked to keep a diary of all his insomnia-related symptoms. All outcome measures substantially improved. Moreover, during the observation period, the patient's sleep quality did not worsen. LESSONS: After acupuncture treatment, improvements of subjective symptoms such as unrefreshing sleep, sleep disturbances, accompanied symptoms (morning headache, fatigue, and mood worsening) were observed. Remarkable improvement was recorded by polysomnographic parameters. The costs of the treatment of insomnia may be reduced, if this therapy was proved useful in future controlled studies. [Mh] Termos MeSH primário: Terapia por Acupuntura/métodos Distúrbios do Início e da Manutenção do Sono/terapia [Mh] Termos MeSH secundário: Adulto Doença Crônica Fadiga/etiologia Seguimentos Cefaleia/etiologia Seres Humanos Masculino Polissonografia Distúrbios do Início e da Manutenção do Sono/complicações [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180220 [Lr] Data última revisão: 180220 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180201 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000009471

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[PMID]: 28449915 [Au] Autor: Lisabeth LD; Sánchez BN; Chervin RD; Morgenstern LB; Zahuranec DB; Tower SD; Brown DL [Ad] Endereço: Department of Epidemiology, University of Michigan School of Public Health, MI, USA; Stroke Program, University of Michigan Health System, MI, USA. Electronic address: llisabet@umich.edu. [Ti] Título: High prevalence of poststroke sleep-disordered breathing in Mexican Americans. [So] Source: Sleep Med;33:97-102, 2017 May. [Is] ISSN: 1878-5506 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: OBJECTIVE: The purpose of this study is to compare sleep-disordered breathing (SDB) prevalence and severity after stroke between Mexican Americans (MAs) and non-Hispanic whites (NHWs). PATIENTS/METHODS: Ischemic stroke (IS) patients within ∼30 days of onset were identified from the population-based BASIC Project (2010-2014) and offered screening with an overnight cardiopulmonary monitoring device, ApneaLink Plus™. The number of apneas and hypopneas per hour, as reflected by the apnea/hypopnea index (AHI), was used to measure SDB severity; SDB was defined as AHI ≥10. Ethnicity, demographics, and risk factors were collected from interviews and medical records. Log and negative-binomial regression models were used to determine prevalence ratios (PRs) and apnea/hypopnea event rate ratios (RRs) comparing MAs with NHWs after adjustment for demographics, risk factors, and stroke severity. RESULTS: A total of 549 IS cases had AHI data. The median age was 65 years (interquartile range (IQR): 57-76), 55% were men, and 65% were MA. The MAs had a higher prevalence of SDB (68.5%) than NHWs (49.5%) in unadjusted (PR = 1.38; 95% confidence interval (CI): 1.14-1.67) and adjusted analyses (PR = 1.21; 95% CI: 1.01-1.46). The median AHI was 16 (IQR: 7-31) in MAs and nine (IQR: 5-24) in NHWs. The severity of SDB (rate of apneas/hypopneas) was higher in MAs than NHWs in unadjusted (RR = 1.31; 95% CI: 1.09-1.58) but not adjusted analysis (RR = 1.14; 95% CI: 0.95-1.38). There was no ethnic difference in severity among subjects with SDB. CONCLUSION: More than two-thirds of MA stroke patients had SDB, which was almost 40% more common among MAs than NHWs. Physicians treating MA patients after stroke should have a high index of suspicion for SDB, a treatable condition that could otherwise have adverse impact. [Mh] Termos MeSH primário: Isquemia Encefálica/complicações Americanos Mexicanos/estatística & dados numéricos Polissonografia/instrumentação Prevalência Síndromes da Apneia do Sono/complicações Acidente Vascular Cerebral/complicações [Mh] Termos MeSH secundário: Idoso Grupos de Populações Continentais/etnologia Grupo com Ancestrais do Continente Europeu/estatística & dados numéricos Feminino Seres Humanos Masculino Meia-Idade Polissonografia/métodos Fatores de Risco Índice de Gravidade de Doença Síndromes da Apneia do Sono/epidemiologia Síndromes da Apneia do Sono/fisiopatologia Acidente Vascular Cerebral/epidemiologia Acidente Vascular Cerebral/etnologia [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180216 [Lr] Data última revisão: 180216 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170429 [St] Status: MEDLINE

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[PMID]: 28449908 [Au] Autor: Fisser C; Marcinek A; Hetzenecker A; Debl K; Luchner A; Sterz U; Priefert J; Zeman F; Kohler M; Maier LS; Buchner S; Arzt M [Ad] Endereço: Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany. Electronic address: christoph.fisser@ukr.de. [Ti] Título: Association of sleep-disordered breathing and disturbed cardiac repolarization in patients with ST-segment elevation myocardial infarction. [So] Source: Sleep Med;33:61-67, 2017 May. [Is] ISSN: 1878-5506 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: OBJECTIVE: In patients with ST-segment elevation myocardial infarction (STEMI), disturbed cardiac repolarization before percutaneous coronary intervention (PCI) is a risk factor for malignant ventricular arrhythmia. We tested the hypothesis that sleep-disordered breathing (SDB) in patients with STEMI is associated with disturbed cardiac repolarization. METHODS: Thirty-three patients with STEMI who underwent PCI were prospectively enrolled. To assess cardiac repolarization, the heart-rate corrected interval from the peak of the T wave to the end of the T wave (TpTec) and QTc intervals were assessed with 12-lead electrocardiography before PCI, within 24 h after PCI, and 12 weeks after PCI. SDB defined as an apnea-hypopnea index (AHI) ≥15 per hour was diagnosed by polysomnography. RESULTS: Before PCI, patients with SDB had a significantly prolonged TpTec interval compared to patients without SDB (133 vs 104 ms, p = 0.035). Within 24 h after PCI, the TpTec interval was 107 vs 92 ms (p = 0.178). QTc intervals showed a similar pattern (pre-PCI: 443 vs 423 ms, p = 0.199; post-PCI: 458 vs 432 ms, p = 0.115). In multiple linear regression analyses, AHI was significantly associated with prolonged TpTec intervals (pre-PCI: B-coefficient = 1.11, 95% confidence interval (CI) 0.48-1.74, p = 0.001; post-PCI: B = 0.97, 95% CI 0.29-1.65, p = 0.007), prolonged QTc intervals (pre-PCI: B = 1.05, 95% CI 0.20-1.91, p = 0.018; post-PCI: B = 1.37, 95% CI 0.51-2.24, p = 0.003), and higher TpTe/QT-ratios (pre-PCI: B = 0.16, 95% CI 0.05-0.27, p = 0.007; post-PCI: B = 0.13, 95% CI < 0.01-0.25, p = 0.036), independent of known risk factors for cardiac arrhythmia. CONCLUSION: In patients with STEMI, SDB was significantly associated with disturbed cardiac repolarization before and after PCI, independent of known risk factors. These findings suggest that SDB may contribute to the risk of developing malignant ventricular arrhythmia. [Mh] Termos MeSH primário: Arritmias Cardíacas/complicações Infarto do Miocárdio/complicações Intervenção Coronária Percutânea/métodos Síndromes da Apneia do Sono/complicações [Mh] Termos MeSH secundário: Adulto Idoso Arritmias Cardíacas/fisiopatologia Eletrocardiografia/métodos Feminino Alemanha/epidemiologia Coração/fisiopatologia Seres Humanos Masculino Meia-Idade Infarto do Miocárdio/fisiopatologia Intervenção Coronária Percutânea/efeitos adversos Polissonografia/métodos Estudos Prospectivos Fatores de Risco Síndromes da Apneia do Sono/diagnóstico Síndromes da Apneia do Sono/fisiopatologia [Pt] Tipo de publicação: JOURNAL ARTICLE; OBSERVATIONAL STUDY [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180216 [Lr] Data última revisão: 180216 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170429 [St] Status: MEDLINE

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[PMID]: 28449905 [Au] Autor: Xu X; Wu H; Zhuang J; Chen K; Huang B; Zhao Z; Zhao Z [Ad] Endereço: Department of Neurology, Changzheng Hospital, Second Military Medical University of PLA, Shanghai, PR China. [Ti] Título: Sleep-wake patterns, non-rapid eye movement, and rapid eye movement sleep cycles in teenage narcolepsy. [So] Source: Sleep Med;33:47-56, 2017 May. [Is] ISSN: 1878-5506 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: BACKGROUND: To further characterize sleep disorders associated with narcolepsy, we assessed the sleep-wake patterns, rapid eye movement (REM), and non-REM (NREM) sleep cycles in Chinese teenagers with narcolepsy. METHODS: A total of 14 Chinese type 1 narcoleptic patients (13.4 ± 2.6 years of age) and 14 healthy age- and sex-matched control subjects (13.6 ± 1.8 years of age) were recruited. Ambulatory 24-h polysomnography was recorded for two days, with test subjects adapting to the instruments on day one and the study data collection performed on day two. RESULTS: Compared with the controls, the narcoleptic patients showed a 1.5-fold increase in total sleep time over 24 h, characterized by enhanced slow-wave sleep and REM sleep. Frequent sleep-wake transitions were identified in nocturnal sleep with all sleep stages switching to wakefulness, with more awakenings and time spent in wakefulness after sleep onset. Despite eight cases of narcolepsy with sleep onset REM periods at night, the mean duration of NREM-REM sleep cycle episode and the ratio of REM/NREM sleep between patients and controls were not significantly different. CONCLUSION: Our study identified hypersomnia in teenage narcolepsy despite excessive daytime sleepiness. Sleep fragmentation extended to all sleep stages, indicating impaired sleep-wake cycles and instability of sleep stages. The limited effects on NREM-REM sleep cycles suggest the relative conservation of ultradian regulation of sleep. [Mh] Termos MeSH primário: Narcolepsia/diagnóstico Narcolepsia/fisiopatologia Fases do Sono/fisiologia Sono REM/fisiologia [Mh] Termos MeSH secundário: Adolescente Estudos de Casos e Controles Criança China/epidemiologia Ritmo Circadiano/fisiologia Distúrbios do Sono por Sonolência Excessiva/complicações Distúrbios do Sono por Sonolência Excessiva/epidemiologia Distúrbios do Sono por Sonolência Excessiva/etiologia Feminino Seres Humanos Masculino Narcolepsia/epidemiologia Polissonografia/métodos Privação do Sono/diagnóstico Privação do Sono/fisiopatologia Ritmo Ultradiano/fisiologia Vigília/fisiologia [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180216 [Lr] Data última revisão: 180216 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170429 [St] Status: MEDLINE

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1			PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
2	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

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