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[PMID]:29384940
[Au] Autor:Hong SM; Hur YI
[Ad] Endereço:Department of Internal Medicine.
[Ti] Título:Relationship between obesity and depression in Korean adults: Korea National Health and Nutrition Examination Survey 2014.
[So] Source:Medicine (Baltimore);96(52):e9478, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Previous studies on the relationship between obesity and depression have produced conflicting results. And only a limited number of studies have been conducted in Asians, and few large-scale nationwide studies have been conducted in Korean populations.We investigated the relationship between obesity and depression in Korean adults using data from a population-based sample from the 2014 Korea National Health and Nutritional Examination Survey (KNHANES) by cross-sectional study.In total, 4026 subjects (1692 men, 2334 women) aged 19 to 69 years participated in the 2014 KNHANES. Current depression was defined as a score ≥10 on the 9-item Patient Health Questionnaire. Height and weight were measured and the body mass index (BMI) was calculated. The participants were asked to complete questionnaires about socio-demographic factors and disease comorbidities, and health-related behaviors. The chi-squared test and multivariate logistic regression analyses were performed to examine the relationship between obesity and depression.Depression was diagnosed in 5.7% of the study participants (3.9% of men, 7.0% of women). According to body weight status, there was a significant difference in the prevalence of depression (underweight: 16.2%, normal weight: 5.5%, overweight: 4.3%, obese [BMI ≥30]: 6.9%). Compared with the normal weight group, the underweight group had a higher adjusted odds ratio (OR) for depression (OR = 3.27, 95% confidence interval [CI]: 1.22, 8.75 in men; OR = 2.00, 95% CI: 1.12, 3.57 in women). Overweight (OR = 0.60, 95% CI: 0.32, 1.13) and obese (OR = 0.62, 95% CI: 0.17, 2.27) men had lower ORs for depression, but this trend was not significant. Compared with normal weight women, obese women had higher adjusted ORs for depression (OR = 1.75, 95% CI: 0.79, 3.88), while overweight women had lower ORs for depression (OR = 0.90, 95% CI: 0.56, 1.45), but these trends were not significant.This study shows differences in the risk of depression depending upon body weight status. Being underweight was correlated with a high risk of developing depression in both men and women, but obesity cannot be ruled out as a risk factor for this condition.
[Mh] Termos MeSH primário: Transtorno Depressivo/epidemiologia
Obesidade/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Índice de Massa Corporal
Pesos e Medidas Corporais
Estudos Transversais
Feminino
Seres Humanos
Masculino
Meia-Idade
Inquéritos Nutricionais
Sobrepeso/epidemiologia
Prevalência
República da Coreia/epidemiologia
Fatores de Risco
Distribuição por Sexo
Fatores Socioeconômicos
Magreza/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009478


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[PMID]:29381952
[Au] Autor:Song SJ; Han K; Lee SS; Park JB
[Ad] Endereço:Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine.
[Ti] Título:Association between the number of natural teeth and diabetic retinopathy among type 2 diabetes mellitus: The Korea national health and nutrition examination survey.
[So] Source:Medicine (Baltimore);96(47):e8694, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to investigate the relationship between the number of teeth and diabetic retinopathy among Korean population.This was a retrospective analysis using data of total 45,811 individuals who participated in the Korea National Health and Nutrition Examination Survey (KNHANES) 2008 to 2012. Among these, 2593 (5.7%) participants were identified as having type 2 diabetes mellitus. After excluding participants without ophthalmic evaluation or other variables, 2078 (80%) participants were included. Demographic factors including dental status were analyzed and compared between participants with and without diabetic retinopathy.Among the 2078 type 2 diabetes, 358 (17.2%) had diabetic retinopathy. Type 2 diabetes with fewer teeth were more likely to have diabetic retinopathy (P < .001). Multivariate analysis showed that type 2 diabetes with < 20 teeth had an 8.7-fold risk of having vision-threatening diabetic retinopathy when compared with type 2 diabetes with ≥28 teeth (95% confidence interval: 2.69-28.3) after adjusting for age, sex, body mass index, smoking, drinking, exercise, hypertension, diabetes mellitus duration, and glycated hemoglobin level.The number of teeth was found to be an independent risk factor for diabetic retinopathy. Thus, a comprehensive approach of dentists and ophthalmologists is needed to minimize the complications of diabetes mellitus. Whether the teeth number reflects microvascular changes of the retina among type 2 diabetes warrants further investigation.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/epidemiologia
Retinopatia Diabética/epidemiologia
Perda de Dente/epidemiologia
[Mh] Termos MeSH secundário: Idoso
Consumo de Bebidas Alcoólicas/epidemiologia
Pesos e Medidas Corporais
Exercício
Feminino
Seres Humanos
Masculino
Meia-Idade
Inquéritos Nutricionais
República da Coreia/epidemiologia
Estudos Retrospectivos
Fumar/epidemiologia
Fatores Socioeconômicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008694


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[PMID]:27774807
[Au] Autor:Stepanikova I; Oates GR; Bateman LB
[Ad] Endereço:a Department of Sociology , University of Alabama at Birmingham , Birmingham , AL , USA.
[Ti] Título:Does one size fit all? The role of body mass index and waist circumference in systemic inflammation in midlife by race and gender.
[So] Source:Ethn Health;22(2):169-183, 2017 04.
[Is] ISSN:1465-3419
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: This study investigates the associations of body mass index (BMI) and waist circumference (WC) with markers of systemic inflammation in midlife by race and gender. DESIGN: Data were obtained from the Survey of Midlife in the United States, a cross-sectional, observational study of Americans 35 years old or older (White men: N = 410; White women: N = 490; Black men: N = 58; Black women: N = 117). Inflammation was measured by concentrations of fibrinogen and C-reactive protein (CRP) in fasting plasma and concentrations of E-selectin and interleukin-6 (IL-6) in fasting serum. Anthropometric data were used to obtain BMI and WC. Socio-demographic and health-related factors were assessed with a survey. Multivariate models by race and gender were estimated to test the roles of BMI and WC for each inflammation marker. RESULTS: Compared to White men, Black women have higher BMI and higher levels of all four inflammation markers; White women have lower BMI, lower WC, and lower E-selectin and fibrinogen but higher CRP; and Black men have higher fibrinogen. After adjusting for socio-demographic and health-related covariates as well as perceived discrimination, WC is associated with all four markers of inflammation among White men and women; with three markers (fibrinogen, CRP, and IL-6) of inflammation among Black women; and with CRP (and marginally with fibrinogen and E-selectin) among Black men. BMI is associated with higher CRP and fibrinogen among Black men (marginally so for White men) but not for women of either race. CONCLUSIONS: WC shows more consistent associations with inflammation markers than BMI, although the relationships vary by inflammation marker and population group. Our findings suggest that WC is a risk factor for systemic inflammation among White and Black men and women, and BMI is an additional risk factor for Black men.
[Mh] Termos MeSH primário: Afroamericanos/estatística & dados numéricos
Índice de Massa Corporal
Grupo com Ancestrais do Continente Europeu/estatística & dados numéricos
Inflamação/etnologia
Circunferência da Cintura
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Biomarcadores
Pesos e Medidas Corporais
Proteína C-Reativa/biossíntese
Estudos Transversais
Selectina E/biossíntese
Feminino
Fibrinogênio/biossíntese
Seres Humanos
Inflamação/fisiopatologia
Mediadores da Inflamação
Interleucina-6/biossíntese
Masculino
Meia-Idade
Fatores de Risco
Fatores Sexuais
Fatores Socioeconômicos
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biomarkers); 0 (E-Selectin); 0 (Inflammation Mediators); 0 (Interleukin-6); 9001-32-5 (Fibrinogen); 9007-41-4 (C-Reactive Protein)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1080/13557858.2016.1235681


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Registro de Ensaios Clínicos
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[PMID]:28468687
[Au] Autor:De Cocker K; De Bourdeaudhuij I; Cardon G; Vandelanotte C
[Ad] Endereço:Department of Movement and Sports Sciences, Ghent University, Watersportlaan 2, B-9000, Ghent, Belgium.
[Ti] Título:What are the working mechanisms of a web-based workplace sitting intervention targeting psychosocial factors and action planning?
[So] Source:BMC Public Health;17(1):382, 2017 05 03.
[Is] ISSN:1471-2458
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Office workers demonstrate high levels of sitting on workdays. As sitting is positively associated with adverse health risks in adults, a theory-driven web-based computer-tailored intervention to influence workplace sitting, named 'Start to Stand,' was developed. The intervention was found to be effective in reducing self-reported workplace sitting among Flemish employees. The aim of this study was to investigate through which mechanisms the web-based computer-tailored intervention influenced self-reported workplace sitting. METHODS: Employees (n = 155) participated in a clustered randomised controlled trial and reported socio-demographics (age, gender, education), work-related (hours at work, employment duration), health-related (weight and height, workplace sitting and physical activity) and psychosocial (knowledge, attitudes, self-efficacy, social support, intention regarding (changing) sitting behaviours) variables at baseline and 1-month follow-up. The product-of-coefficients test of MacKinnon based on multiple linear regression analyses was conducted to examine the mediating role of five psychosocial factors (knowledge, attitudes, self-efficacy, social support, intention). The influence of one self-regulation skill (action planning) in the association between the intervention and self-reported workplace sitting time was investigated via moderation analyses. RESULTS: The intervention had a positive influence on knowledge (p = 0.040), but none of the psychosocial variables did mediate the intervention effect on self-reported workplace sitting. Action planning was found to be a significant moderator (p < 0.001) as the decrease in self-reported workplace sitting only occurred in the group completing an action plan. CONCLUSIONS: Future interventions aimed at reducing employees' workplace sitting are suggested to focus on self-regulatory skills and promote action planning when using web-based computer-tailored advice. TRIAL REGISTRATION: Clinicaltrials.gov NCT02672215 ; (Archived by WebCite at https://clinicaltrials.gov/ct2/show/NCT02672215 ).
[Mh] Termos MeSH primário: Exercício
Promoção da Saúde/métodos
Postura
Estilo de Vida Sedentário
Local de Trabalho/organização & administração
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Pesos e Medidas Corporais
Computadores
Feminino
Conhecimentos, Atitudes e Prática em Saúde
Seres Humanos
Internet
Masculino
Meia-Idade
Saúde do Trabalhador
Autoeficácia
Autorrelato
Fatores Sexuais
Apoio Social
Sociobiologia
Local de Trabalho/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180121
[Lr] Data última revisão:
180121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1186/s12889-017-4325-5


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[PMID]:29245334
[Au] Autor:Chua CS; Huang SY; Cheng CW; Bai CH; Hsu CY; Chiu HW; Hsu JL
[Ad] Endereço:aGraduate Institute of Biomedical Informatics, Taipei Medical UniversitybDivision of Gastroenterology, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, TaiwancWestern Medicine Division, Hospital Lam Wah Ee, Penang, MalaysiadSchool of Nutrition and Health Sciences, Taipei Medical UniversityeDepartment of Transportation and Logistics Management, National Chiao Tung UniversityfDepartment of Public Health, School of Medicine, College of Medicine, Taipei Medical UniversitygSchool of Public Health, College of Public Health and Nutrition, Taipei Medical UniversityhDepartment of Information Management, National Taipei University of Nursing and Health SciencesiMaster Program in Global Health and Development, College of Public Health and Nutrition, Taipei Medical UniversityjDepartment of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and College of Medicine, Chang-Gung University, TaoyuankGraduate Institute of Humanities in Medicine, Taipei Medical University, Taipei, Taiwan.
[Ti] Título:Fatty acid components in Asian female patients with irritable bowel syndrome.
[So] Source:Medicine (Baltimore);96(49):e9094, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Abdominal pain is one of the key symptoms of irritable bowel syndrome (IBS). Studies have indicated an increase in the incidence of IBS in Asia. However, yet the pathophysiology of this disease remains unknown. Women are more likely to develop the condition than men, especially the constipation-predominant type. Essential fatty acid (EFA) malnutrition is one of several theories discussing the mechanism of IBS.The authors hypothesized that significant EFA deficiency may cause abdominal pain in patients with IBS. However, because patterns in the oral intake of EFAs differ between cultures, the authors narrowed this study to examine the nutritional status of Asian female patients with IBSThe authors investigated Asian female patients with IBS and compared them with a group of healthy controls. Thirty patients with IBS and 39 healthy individuals were included in this study. The participants' age, height, weight, and waist size were recorded. The 24-item Hamilton Depression Rating Scale was documented. Both erythrocyte and plasma fatty acid content were analyzed through gas-liquid chromatography.The authors found that patients with IBS exhibited significantly higher scores for depression, higher proportions of plasma saturated fatty acids and monounsaturated fatty acids, and lower proportions of docosahexaenoic acid and total omega-3 polyunsaturated fatty acids in plasma are associated with IBS in Asian female patients. Further study is indicated to confirm the causality of this association.
[Mh] Termos MeSH primário: Depressão/epidemiologia
Ácidos Graxos/sangue
Síndrome do Intestino Irritável/sangue
Síndrome do Intestino Irritável/epidemiologia
[Mh] Termos MeSH secundário: Dor Abdominal/sangue
Adulto
Grupo com Ancestrais do Continente Asiático
Pesos e Medidas Corporais
Eritrócitos/metabolismo
Ácidos Graxos Essenciais
Ácidos Graxos Monoinsaturados/sangue
Ácidos Graxos Ômega-3/sangue
Ácidos Graxos Insaturados/sangue
Feminino
Seres Humanos
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Fatty Acids, Essential); 0 (Fatty Acids, Monounsaturated); 0 (Fatty Acids, Omega-3); 0 (Fatty Acids, Unsaturated)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009094


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[PMID]:28464868
[Au] Autor:Galgamuwa LS; Iddawela D; Dharmaratne SD; Galgamuwa GLS
[Ad] Endereço:Department of Parasitology, Faculty of Medicine, University of Peradeniya, Peradeniya, 20400, Sri Lanka.
[Ti] Título:Nutritional status and correlated socio-economic factors among preschool and school children in plantation communities, Sri Lanka.
[So] Source:BMC Public Health;17(1):377, 2017 05 02.
[Is] ISSN:1471-2458
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Child malnutrition is a major public health concern worldwide, leading to higher morbidity and mortality. It is mostly preventable through public health and economic development. The aim of the present study was to determine socio-economic factors associated with nutritional status among children in plantation communities, Sri Lanka. METHODS: A cross-sectional study was performed among preschool and school going children in three rural communities of Sri Lanka from January to August 2014. Demographic and household characteristics were documented and anthropometric measurements were collected to calculate weight-for-age (WAZ), height-for-age (HAZ) and BMI-for-age (BAZ). Anthroplus, epiinfo and SPSS versions were used for the analysis of data. RESULTS: A total of 547 children (aged 1-15 years, mean 7.0 ± 3.6 years, 53% female) participated in the study. 35.6%, 26.9% and 32.9% of children were underweight, stunting and wasting respectively. Undernutrition was more common in primary school children. Maternal employment, high number of siblings, high birth orders and female children were significantly associated with undernutrition among preschool children. Living in small houses, large number of family members, low monthly income and maternal employment were significantly associated with undernutrition among school children. CONCLUSIONS: Child undernutrition is a major public health concern in the plantation sector, Sri Lanka. Health education programs among the study population could be effective for solving the problem.
[Mh] Termos MeSH primário: Transtornos da Nutrição Infantil/epidemiologia
População Rural
Magreza/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Ordem de Nascimento
Pesos e Medidas Corporais
Criança
Pré-Escolar
Estudos Transversais
Feminino
Seres Humanos
Lactente
Masculino
Estado Nutricional
Fatores Socioeconômicos
Sri Lanka/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1186/s12889-017-4311-y


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[PMID]:28465054
[Au] Autor:Manuyakorn W; Bamrungchaowkasem B; Ruangwattanapaisarn N; Kamchaisatian W; Benjaponpitak S
[Ad] Endereço:Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. Electronic address: wiparatm@gmail.com.
[Ti] Título:Optimal needle length for epinephrine prefilled syringe in children.
[So] Source:Ann Allergy Asthma Immunol;118(6):740-741.e1, 2017 06.
[Is] ISSN:1534-4436
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Broncodilatadores/administração & dosagem
Epinefrina/administração & dosagem
Injeções Intramusculares/instrumentação
Agulhas
[Mh] Termos MeSH secundário: Pesos e Medidas Corporais
Pré-Escolar
Estudos Transversais
Feminino
Seres Humanos
Lactente
Masculino
Seringas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bronchodilator Agents); YKH834O4BH (Epinephrine)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171212
[Lr] Data última revisão:
171212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


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[PMID]:28886047
[Au] Autor:Nguyen KA; Peer N; de Villiers A; Mukasa B; Matsha TE; Mills EJ; Kengne AP
[Ad] Endereço:Non-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town, South Africa.
[Ti] Título:Optimal waist circumference threshold for diagnosing metabolic syndrome in African people living with HIV infection.
[So] Source:PLoS One;12(9):e0183029, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The applicability of the internationally advocated cut-off points of waist circumference (WC) derived from Caucasians to diagnose metabolic syndrome (MS) in HIV-infected Africans is unknown. This study aimed to determine the optimal WC cutoffs for MS diagnosis in HIV-infected people receiving care at public healthcare facilities in the Western Cape Province in South Africa. METHODS: Data from 748 randomly selected participants (591 women), with a median age of 38 years, were analysed. The Youden's index and the top-left-point approaches were used to determine the optimal cutoffs of WC for predicting ≥2 non-adipose MS components. RESULTS: The two approaches generated the same WC cut-off point in women, 92 cm (sensitivity 64%, specificity 64%) but different cut-off points in men: 87 cm (sensitivity 48%, specificity 85%) based on the Younden's index and 83 cm (sensitivity 59%, specificity 74%) by the top-left-point method. The advocated thresholds of 94 cm in men had low sensitivity (30%) but high specificity (92%) whereas 80 cm in women showed low specificity (32%) but high sensitivity (85%) for diagnosing MS in this sample. Most African-specific cut-off points performed well, with 90 cm providing acceptable performance in both men (sensitivity 43%, specificity 88%) and women (sensitivity 66%, specificity 59%). CONCLUSIONS: This study underlines the sub-optimal performance of internationally recommended WC thresholds for MS diagnosis in HIV-infected Africans, and supports the need to revisit the guidelines on WC criterion in African population across the board. A single threshold of 90 cm for both genders would be a practical suggestion.
[Mh] Termos MeSH primário: Infecções por HIV/complicações
Síndrome Metabólica/complicações
Síndrome Metabólica/diagnóstico
Circunferência da Cintura
[Mh] Termos MeSH secundário: Adiposidade
Adulto
Biomarcadores
Pressão Sanguínea
Pesos e Medidas Corporais
Estudos Transversais
Feminino
Infecções por HIV/epidemiologia
Seres Humanos
Masculino
Síndrome Metabólica/epidemiologia
Meia-Idade
Curva ROC
Valores de Referência
Reprodutibilidade dos Testes
África do Sul/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183029


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[PMID]:28886024
[Au] Autor:Pelusi C; Giagulli VA; Baccini M; Fanelli F; Mezzullo M; Fazzini A; Bianchi N; Carbone MD; De Pergola G; Mastroroberto M; Morselli Labate AM; Pasquali R
[Ad] Endereço:Division of Endocrinology and Center for Applied Biomedical Research, Department of Medical & Surgical Sciences, Alma Mater Studiorum, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.
[Ti] Título:Clomiphene citrate effect in obese men with low serum testosterone treated with metformin due to dysmetabolic disorders: A randomized, double-blind, placebo-controlled study.
[So] Source:PLoS One;12(9):e0183369, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Low testosterone (T) levels are often found in obese men with impaired glucose tolerance (IGT) and overt type 2 diabetes (T2DM); however, the mechanisms underlying this condition and its correct therapy are still under debate. OBJECTIVE: To evaluate the effectiveness of clomiphene citrate (CC) in increasing endogenous T levels in obese men with low serum T and with IGT or T2DM treated with metformin (MET). DESIGN: Cross-over, randomized, double-blind, placebo-controlled study. METHODS: 24 obese men, aged 47.3 ±. 6.3 (range 35-55 years), with low T level (≤3 ng/mL) and naïve diagnosis of IGT or T2DM were included. Subjects were randomized to CC 25 mg/day or placebo (Plac) with MET 2 g/day for 3 months. After a 6-week wash-out period, subjects were moved to the alternative arm for additional 3 months. Clinical evaluation and blood exams performed prior to and at the end of treatment. RESULTS: Of 24 randomized, 21 were evaluable, classified as IGT (n = 11) or T2DM (n = 10). Compared to baseline levels, T levels increased significantly after 3 months of CC treatment (3.03±0.80 to 5.99±1.67 ng/mL P<0.001) but not after the Plac treatment (2.87±0.78 to 3.09±0.84 ng/mL P<0.001 between the treatments). T changes were similar in IGT and T2DM subjects. Gonadotropins as well raised significantly after CC treatment (LH 3.83±1.45 to 8.53±6.40 mU/mL; FSH 4.84±1.67 to 10.15±5.08 mU/mL P<0.001 respectively), whereas no changes for LH (3.51±1.59 to 3.63±1.39 mU/mL) but a smooth increased for FSH (4.61±2.49 to 5.39±2.65 mU/mL; P = 0.004) were shown after Plac treatment (LH P = 0.001 and FSH P = 0.002 between treatments). Furthermore, fasting glucose (106.8±23.2 to 101.1±25.7 mg/dL; P = 0.004), insulin (19.3±12.1 to 15.6±10.1 µU/mL; P = 0.010) and HOMA-IR (4.94±2.89 to 3.69±2.12; P = 0.001) decreased significantly during the CC treatment period, whereas no significant changes were observed in any of these parameters in the Plac treatment. CONCLUSIONS: A low dose of CC therapy was able to significantly increase serum T levels in all participants with mild modifications of clinical and metabolic parameters. TRIAL REGISTRATION: EudraCT 2011-000439-10.
[Mh] Termos MeSH primário: Clomifeno/uso terapêutico
Hipoglicemiantes/uso terapêutico
Metformina/uso terapêutico
Obesidade/sangue
Obesidade/tratamento farmacológico
Moduladores Seletivos de Receptor Estrogênico/uso terapêutico
Testosterona/sangue
[Mh] Termos MeSH secundário: Adulto
Biomarcadores
Pesos e Medidas Corporais
Clomifeno/administração & dosagem
Clomifeno/efeitos adversos
Metabolismo Energético/efeitos dos fármacos
Hormônios/sangue
Seres Humanos
Hipoglicemiantes/administração & dosagem
Hipoglicemiantes/efeitos adversos
Masculino
Metformina/administração & dosagem
Metformina/efeitos adversos
Meia-Idade
Obesidade/diagnóstico
Moduladores Seletivos de Receptor Estrogênico/administração & dosagem
Moduladores Seletivos de Receptor Estrogênico/efeitos adversos
Resultado do Tratamento
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Biomarkers); 0 (Hormones); 0 (Hypoglycemic Agents); 0 (Selective Estrogen Receptor Modulators); 1HRS458QU2 (Clomiphene); 3XMK78S47O (Testosterone); 9100L32L2N (Metformin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183369


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[PMID]:28834889
[Au] Autor:Lee YB; Yu J; Choi HH; Jeon BS; Kim HK; Kim SW; Kim SS; Park YG; Chae HS
[Ad] Endereço:aDepartment of Dermatology, The Catholic University of Korea bDepartment of Internal Medicine, HeeMyoung General Hospital cDepartment of Internal Medicine dDepartment of Medical Statistics, The Catholic University of Korea, Seoul, South Korea.
[Ti] Título:The association between peptic ulcer diseases and mental health problems: A population-based study: a STROBE compliant article.
[So] Source:Medicine (Baltimore);96(34):e7828, 2017 Aug.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study aimed to investigate the association between the prevalence of peptic ulcer disease (PUD) and mental health problems, such as severe stress, depressive mood, and suicidal ideation.The population-based cross-sectional study was comprised of 14,266 subjects participating in the fourth annual Korea National Health and Nutrition Examination survey from 2007 to 2009. The participants were divided into 2 groups according to the self-reported questionnaires: the PUD group and the non-PUD group. The association between PUD and mental health problems, such as severe stress, depressed mood, suicidal ideation, and psychological counseling history, were evaluated by using multivariate analysis and logistic regression.Among the 14,266 participants over 19-years old, 813 participants (5.6%) had PUD. Compared to the non-PUD group (n = 13,453), the PUD group had a significantly higher percentage of males, current smokers, and heavy drinkers, lower education status, lower income, and greater presence of diabetes mellitus, hypertension, metabolic syndrome and mental health problems, including severe stress, depressed mood, suicidal ideation, and psychological counseling history. After adjustment for lifestyle and medical and environmental factors, mental health problems were found to be associated with a significantly higher risk for PUD.Psychological problems, such as severe stress, depressed mood, suicidal ideation, and psychological counseling, were associated with PUD prevalence.
[Mh] Termos MeSH primário: Depressão/epidemiologia
Saúde Mental/estatística & dados numéricos
Úlcera Péptica/epidemiologia
Estresse Psicológico/epidemiologia
Ideação Suicida
[Mh] Termos MeSH secundário: Adulto
Idoso
Consumo de Bebidas Alcoólicas/epidemiologia
Pesos e Medidas Corporais
Comorbidade
Aconselhamento/estatística & dados numéricos
Estudos Transversais
Feminino
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Prevalência
República da Coreia/epidemiologia
Fatores de Risco
Distribuição por Sexo
Fumar/epidemiologia
Fatores Socioeconômicos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007828



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