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[PMID]: 28453637 [Au] Autor: Daymont C; Ross ME; Russell Localio A; Fiks AG; Wasserman RC; Grundmeier RW [Ad] Endereço: Departments of Pediatrics and Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA. [Ti] Título: Automated identification of implausible values in growth data from pediatric electronic health records. [So] Source: J Am Med Inform Assoc;24(6):1080-1087, 2017 Nov 01. [Is] ISSN: 1527-974X [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Objective: Large electronic health record (EHR) datasets are increasingly used to facilitate research on growth, but measurement and recording errors can lead to biased results. We developed and tested an automated method for identifying implausible values in pediatric EHR growth data. Materials and Methods: Using deidentified data from 46 primary care sites, we developed an algorithm to identify weight and height values that should be excluded from analysis, including implausible values and values that were recorded repeatedly without remeasurement. The foundation of the algorithm is a comparison of each measurement, expressed as a standard deviation score, with a weighted moving average of a child's other measurements. We evaluated the performance of the algorithm by (1) comparing its results with the judgment of physician reviewers for a stratified random selection of 400 measurements and (2) evaluating its accuracy in a dataset with simulated errors. Results: Of 2 000 595 growth measurements from 280 610 patients 1 to 21 years old, 3.8% of weight and 4.5% of height values were identified as implausible or excluded for other reasons. The proportion excluded varied widely by primary care site. The automated method had a sensitivity of 97% (95% confidence interval [CI], 94-99%) and a specificity of 90% (95% CI, 85-94%) for identifying implausible values compared to physician judgment, and identified 95% (weight) and 98% (height) of simulated errors. Discussion and Conclusion: This automated, flexible, and validated method for preparing large datasets will facilitate the use of pediatric EHR growth datasets for research. [Mh] Termos MeSH primário: Algoritmos Registros Eletrônicos de Saúde Gráficos de Crescimento Crescimento [Mh] Termos MeSH secundário: Adolescente Estatura Peso Corporal Criança Pré-Escolar Conjuntos de Dados como Assunto Feminino Seres Humanos Lactente Masculino Atenção Primária à Saúde Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE; VALIDATION STUDIES [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170429 [St] Status: MEDLINE [do] DOI: 10.1093/jamia/ocx037

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[PMID]: 29390353 [Au] Autor: Bourgeois B; Watts K; Thomas DM; Carmichael O; Hu FB; Heo M; Hall JE; Heymsfield SB [Ad] Endereço: Pennington Biomedical Research Center, LSU System, Baton Rouge, LA. [Ti] Título: Associations between height and blood pressure in the United States population. [So] Source: Medicine (Baltimore);96(50):e9233, 2017 Dec. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The mechanisms linking short stature with an increase in cardiovascular and cerebrovascular disease risk remain elusive. This study tested the hypothesis that significant associations are present between height and blood pressure in a representative sample of the US adult population.Participants were 12,988 men and women from a multiethnic sample (age ≥ 18 years) evaluated in the 1999 to 2006 National Health and Nutrition Examination Survey who were not taking antihypertensive medications and who had complete height, weight, % body fat, and systolic and diastolic arterial blood pressure (SBP and DBP) measurements; mean arterial blood pressure and pulse pressure (MBP and PP) were calculated. Multiple regression models for men and women were developed with each blood pressure as dependent variable and height, age, race/ethnicity, body mass index, % body fat, socioeconomic status, activity level, and smoking history as potential independent variables.Greater height was associated with significantly lower SBP and PP, and higher DBP (all P < .001) in combined race/ethnic-sex group models beginning in the 4th decade. Predicted blood pressure differences between people who are short and tall increased thereafter with greater age except for MBP. Socioeconomic status, activity level, and smoking history did not consistently contribute to blood pressure prediction models.Height-associated blood pressure effects were present in US adults who appeared in the 4th decade and increased in magnitude with greater age thereafter. These observations, in the largest and most diverse population sample evaluated to date, provide support for postulated mechanisms linking adult stature with cardiovascular and cerebrovascular disease risk. [Mh] Termos MeSH primário: Pressão Sanguínea/fisiologia Estatura [Mh] Termos MeSH secundário: Adulto Fatores Etários Antropometria Diástole Grupos Étnicos Feminino Seres Humanos Masculino Inquéritos Nutricionais Fatores de Risco Sístole Estados Unidos [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180302 [Lr] Data última revisão: 180302 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180203 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000009233

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[PMID]: 28451759 [Au] Autor: Gurzkowska B; Kulaga Z; Grajda A; Gózdz M; Wojtylo M; Litwin M [Ad] Endereço: Public Health Department, The Children's Memorial Health Institute, al. Dzieci Polskich 20, 04-730, Warsaw, Poland. [Ti] Título: The relationship between selected socioeconomic factors and thinness among Polish school-aged children and adolescents. [So] Source: Eur J Pediatr;176(6):797-806, 2017 Jun. [Is] ISSN: 1432-1076 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: The analysis was performed on a database including 17,427 records of subjects aged 7-18 years, randomly sampled from a population of Polish students. Thinness was determined using international cut-off points, defined to pass through body mass index of 18.5 kg/m at the age of 18. The weighted prevalence of thinness and odds ratios with 95% confidence interval were estimated for gender, birth weight, level of schooling and school location, gross domestic product (GDP) per inhabitant, family income and maternal education. Body height was analysed according to body mass and birth weight categories. The prevalence of thinness was higher among children with low birth weight and among girls. The prevalence of thinness decreased with increasing GDP per inhabitant. In analysis by level of schooling: primary-middle-secondary, prevalence of thinness decreased among boys and increased among girls. Thin students were significantly shorter than other students, and thin girls less likely participated in physical education. CONCLUSION: Gender and socioeconomic factors are important determinants of thinness among Polish children and adolescents. Public health strategies should address family eating practices to prevent negative effects of weight deficit, especially among girls/children from low GDP regions. What is Known: • Socioeconomic factors and gender influence weight status of children and adolescents. What is New: • The first time the prevalence and determinants of thinness based on data from a nationally representative, weighted sample of Polish children aged 7-18 years were presented. • The analysis shows how gender and socioeconomics determinants influence the prevalence of thinness among children and adolescent in post-transformation country and can be used to international comparisons. [Mh] Termos MeSH primário: Fatores Socioeconômicos Magreza/etiologia [Mh] Termos MeSH secundário: Adolescente Peso ao Nascer Estatura Criança Bases de Dados Factuais Feminino Seres Humanos Modelos Lineares Modelos Logísticos Masculino Razão de Chances Polônia/epidemiologia Prevalência Fatores de Risco Fatores Sexuais Magreza/epidemiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180301 [Lr] Data última revisão: 180301 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170429 [St] Status: MEDLINE [do] DOI: 10.1007/s00431-017-2912-1

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[PMID]: 29293634 [Au] Autor: Devaraj S; Quigley NR; Patel PC [Ad] Endereço: Center for Business and Economic Research, Ball State University, Muncie, Indiana, United States of America. [Ti] Título: The effects of skin tone, height, and gender on earnings. [So] Source: PLoS One;13(1):e0190640, 2018. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Using a theoretical approach grounded in implicit bias and stereotyping theories, this study examines the relationship between observable physical characteristics (skin tone, height, and gender) and earnings, as measured by income. Combining separate streams of research on the influence of these three characteristics, we draw from a sample of 31,356 individual-year observations across 4,340 individuals from the National Longitudinal Study of Youth (NLSY) 1997. We find that skin tone, height, and gender interact such that taller males with darker skin tone attain lower earnings; those educated beyond high school, endowed with higher cognitive ability, and at the higher income level (>75th percentile) had even lower levels of earnings relative to individuals with lighter skin tone. The findings have implications for implicit bias theories, stereotyping, and the human capital literature within the fields of management, applied psychology, and economics. [Mh] Termos MeSH primário: Estatura Renda Pigmentação da Pele [Mh] Termos MeSH secundário: Adolescente Feminino Seres Humanos Estudos Longitudinais Masculino Estados Unidos Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180221 [Lr] Data última revisão: 180221 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180103 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0190640

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[PMID]: 29220676 [Au] Autor: Abadi A; Alyass A; Robiou du Pont S; Bolker B; Singh P; Mohan V; Diaz R; Engert JC; Yusuf S; Gerstein HC; Anand SS; Meyre D [Ad] Endereço: Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON L8S 4L8, Canada. [Ti] Título: Penetrance of Polygenic Obesity Susceptibility Loci across the Body Mass Index Distribution. [So] Source: Am J Hum Genet;101(6):925-938, 2017 Dec 07. [Is] ISSN: 1537-6605 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: A growing number of single-nucleotide polymorphisms (SNPs) have been associated with body mass index (BMI) and obesity, but whether the effects of these obesity-susceptibility loci are uniform across the BMI distribution remains unclear. We studied the effects of 37 BMI-associated SNPs in 75,230 adults of European ancestry across BMI percentiles by using conditional quantile regression (CQR) and meta-regression (MR) models. The effects of nine SNPs (24%)-rs1421085 (FTO; p = 8.69 × 10 ), rs6235 (PCSK1; p = 7.11 × 10 ), rs7903146 (TCF7L2; p = 9.60 × 10 ), rs11873305 (MC4R; p = 5.08 × 10 ), rs12617233 (FANCL; p = 5.30 × 10 ), rs11672660 (GIPR; p = 1.64 × 10 ), rs997295 (MAP2K5; p = 3.25 × 10 ), rs6499653 (FTO; p = 6.23 × 10 ), and rs3824755 (NT5C2; p = 7.90 × 10 )-increased significantly across the sample BMI distribution. We showed that such increases stemmed from unadjusted gene interactions that enhanced the effects of SNPs in persons with a high BMI. When 125 height-associated SNPs were analyzed for comparison, only one (<1%), rs6219 (IGF1, p = 1.80 × 10 ), showed effects that varied significantly across height percentiles. Cumulative gene scores of these SNPs (GS-BMI and GS-height) showed that only GS-BMI had effects that increased significantly across the sample distribution (BMI: p = 7.03 × 10 ; height: p = 0.499). Overall, these findings underscore the importance of gene-gene and gene-environment interactions in shaping the genetic architecture of BMI and advance a method for detecting such interactions by using only the sample outcome distribution. [Mh] Termos MeSH primário: Estatura/genética Índice de Massa Corporal Herança Multifatorial/genética Obesidade/genética Penetrância [Mh] Termos MeSH secundário: Adulto Idoso Idoso de 80 Anos ou mais Grupo com Ancestrais do Continente Europeu/genética Frequência do Gene Interação Gene-Ambiente Predisposição Genética para Doença/genética Seres Humanos Meia-Idade Polimorfismo de Nucleotídeo Único/genética Locos de Características Quantitativas/genética Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180221 [Lr] Data última revisão: 180221 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171209 [St] Status: MEDLINE

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[PMID]: 29198721 [Au] Autor: Ning Z; Lee Y; Joshi PK; Wilson JF; Pawitan Y; Shen X [Ad] Endereço: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, SE-171 77 Stockholm, Sweden. [Ti] Título: A Selection Operator for Summary Association Statistics Reveals Allelic Heterogeneity of Complex Traits. [So] Source: Am J Hum Genet;101(6):903-912, 2017 Dec 07. [Is] ISSN: 1537-6605 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: In recent years, as a secondary analysis in genome-wide association studies (GWASs), conditional and joint multiple-SNP analysis (GCTA-COJO) has been successful in allowing the discovery of additional association signals within detected loci. This suggests that many loci mapped in GWASs harbor more than a single causal variant. In order to interpret the underlying mechanism regulating a complex trait of interest in each discovered locus, researchers must assess the magnitude of allelic heterogeneity within the locus. We developed a penalized selection operator for jointly analyzing multiple variants (SOJO) within each mapped locus on the basis of LASSO (least absolute shrinkage and selection operator) regression derived from summary association statistics. We found that, compared to stepwise conditional multiple-SNP analysis, SOJO provided better sensitivity and specificity in predicting the number of alleles associated with complex traits in each locus. SOJO suggested causal variants potentially missed by GCTA-COJO. Compared to using top variants from genome-wide significant loci in GWAS, using SOJO increased the proportion of variance prediction for height by 65% without additional discovery samples or additional loci in the genome. Our empirical results indicate that human height is not only a highly polygenic trait, but also has high allelic heterogeneity within its established hundreds of loci. [Mh] Termos MeSH primário: Estatura/genética Herança Multifatorial/genética Polimorfismo de Nucleotídeo Único/genética [Mh] Termos MeSH secundário: Alelos Índice de Massa Corporal Estudo de Associação Genômica Ampla Seres Humanos Locos de Características Quantitativas [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180221 [Lr] Data última revisão: 180221 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171205 [St] Status: MEDLINE

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[PMID]: 28453057 [Au] Autor: Benjumea-Rincón MV; Parra-Sánchez JH; Ocampo-Téllez PR [Ad] Endereço: Universidad de Caldas, Manizales, Colombia. [Ti] Título: [Correlation of size and age in Colombian indigenous children based on WHO and NCHS references]. [Ti] Título: Concordancia en la talla para la edad entre referencias NCHS y OMS en indígenas colombianos.. [So] Source: Rev Salud Publica (Bogota);18(4):503-515, 2016 Aug. [Is] ISSN: 0124-0064 [Cp] País de publicação: Colombia [La] Idioma: spa [Ab] Resumo: Objective To evaluate the correlation of size, according to age, of the anthropometric growth references of Colombian indigenous children studied in Encuesta Nacional de la Situación Nutricional de Colombia 2010 -ENSIN 2010 (National Survey of Nutrition in Colombia - 2010). Method A secondary analysis of 2598 data of indigenous Colombian children under five years of age, evaluated by ENSIN in 2010, was performed. The considered variables were size according to age, gender, height, place of residence, department and socioeconomic position. The classification of the deficit in size, based on the references of the National Center for Health Statistics (NCHS) and the World Health Organization (WHO), was made by using the Z <-2 score and the Anthro software. The Kappa coefficient was estimated to assess the correlation between anthropometric categories and was classified taking into account the proposal of Altman DG. Results One in four children had a deficit in size in the light of both anthropometric references. The prevalence of the deficit was higher when using the WHO standard, increased with age and was higher in children who resided in low altitude (m). The correlation between the two references was good (kappa ≥0,688, p=0,000) for children of both genders and all ages; the exception corresponded to children of age two, since it was moderate (kappa=0,601, p=0,000). The greatest disagreement in the classification was observed in the category "tall". Conclusion According to the statistical correlation found between the two anthropometric references (WHO vs. NCHS), any reference could be used for assessment of size according to for age. [Mh] Termos MeSH primário: Fatores Etários Estatura/etnologia Índios Sul-Americanos [Mh] Termos MeSH secundário: Pré-Escolar Colômbia Estudos Transversais Feminino Seres Humanos Lactente Recém-Nascido Masculino National Center for Health Statistics (U.S.) Estado Nutricional Valores de Referência Reprodutibilidade dos Testes Estudos Retrospectivos Fatores Sexuais Estados Unidos Organização Mundial da Saúde [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180216 [Lr] Data última revisão: 180216 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170429 [St] Status: MEDLINE

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[PMID]: 29328563 [Au] Autor: Dragovic T; Duran Z; Jelic S; Marinkovic D; Kikovic S; Kuzmic-Jankovic S; Hajdukovic Z [Ti] Título: Coexisting diseases modifying each other's presentation - lack of growth failure in Turner syndrome due to the associated pituitary gigantism. [So] Source: Vojnosanit Pregl;73(10):961-6, 2016 Oct. [Is] ISSN: 0042-8450 [Cp] País de publicação: Serbia [La] Idioma: eng [Ab] Resumo: Introduction: Turner syndrome presents with one of the most frequent chromosomal aberrations in female, typically presented with growth retardation, ovarian insufficiency, facial dysmorphism, and numerous other somatic stigmata. Gigantism is an extremely rare condition resulting from an excessive growth hormone (GH) secretion that occurs during childhood before the fusion of epiphyseal growth plates. The major clinical feature of gigantism is growth acceleration, although these patients also suffer from hypogonadism and soft tissue hypertrophy. Case report: We presented a girl with mosaic Turner syndrome, delayed puberty and normal linear growth for the sex and age, due to the simultaneous GH hypersecretion by pituitary tumor. In the presented case all the typical phenotypic stigmata related to Turner syndrome were missing. Due to excessive pituitary GH secretion during the period while the epiphyseal growth plates of the long bones are still open, characteristic stagnation in longitudinal growth has not been demonstrated. The patient presented with delayed puberty and primary amenorrhea along with a sudden appearance of clinical signs of hypersomatotropinism, which were the reasons for seeking medical help at the age of 16. Conclusion: Physical examination of children presenting with delayed puberty but without growth arrest must include an overall hormonal and genetic testing even in the cases when typical clinical presentations of genetic disorder are absent. To the best of our knowledge, this is the first reported case of simultaneous presence of Turner syndrome and gigantism in the literature. [Mh] Termos MeSH primário: Adenoma/complicações Desenvolvimento do Adolescente Estatura Gigantismo/etiologia Adenoma Hipofisário Secretor de Hormônio do Crescimento/complicações Síndrome de Turner/complicações [Mh] Termos MeSH secundário: Adenoma/sangue Adenoma/fisiopatologia Adenoma/cirurgia Adolescente Amenorreia/etiologia Amenorreia/fisiopatologia Biomarcadores/sangue Feminino Gigantismo/sangue Gigantismo/fisiopatologia Adenoma Hipofisário Secretor de Hormônio do Crescimento/sangue Adenoma Hipofisário Secretor de Hormônio do Crescimento/fisiopatologia Adenoma Hipofisário Secretor de Hormônio do Crescimento/cirurgia Terapia de Reposição Hormonal Hormônio do Crescimento Humano/sangue Seres Humanos Fator de Crescimento Insulin-Like I/metabolismo Imagem por Ressonância Magnética Mosaicismo Puberdade Tardia/etiologia Puberdade Tardia/fisiopatologia Resultado do Tratamento Síndrome de Turner/tratamento farmacológico Síndrome de Turner/genética Síndrome de Turner/fisiopatologia [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biomarkers); 0 (IGF1 protein, human); 12629-01-5 (Human Growth Hormone); 67763-96-6 (Insulin-Like Growth Factor I) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180213 [Lr] Data última revisão: 180213 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180113 [St] Status: MEDLINE [do] DOI: 10.2298/VSP150620014D

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[PMID]: 28452131 [Au] Autor: Floyd B [Ad] Endereço: Anthropology, School of Social Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand. [Ti] Título: The influence of variation in parental height dimorphism on same-sex parent-offspring height differences. [So] Source: Am J Phys Anthropol;163(3):627-632, 2017 07. [Is] ISSN: 1096-8644 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: OBJECTIVE: This study evaluates how adjusting for parental height dimorphism influences height differences among parents and same-sex offspring distinguished by parents' early backgrounds. PARTICIPANTS AND METHODS: Regression analyses using data from independent groups of Taiwanese families, 56 with sons and 51 with daughters, evaluate how adjusting for parental height dimorphism influences same-sex parent-offspring height differences among families grouped by grandfathers' occupations into three status categories reflecting good to relatively poor early parental environments. RESULTS: Parental height dimorphism was statistically significantly associated with same-sex parent-offspring height differences (father-son: mean Δ = 3.88 cm, ß = -71.47 ± 11.49 SE, t = -6.22, p ≤ .0005; mother-daughter: mean Δ = 4.15 cm, ß = 80.46 ± 18.52 SE, t = 4.35, p ≤ .0005). Adjusted mean father-son differences increased significantly across grandfathers' occupation categories (Privileged, Δ = 0.60, Business, Δ = 4.06, Farming & Labor, Δ = 5.28; p = .011). Mother-daughter differences were substantial, from 3.33 cm to 5.06 cm, but did not differ significantly across occupational categories (p = .63). DISCUSSION: Adjustments here for variation in parent height dimorphism did not alter original interpretations that while female growth may be more canalized, it is similarly capable of responding to improvements in developmental contexts. Patterns of same-sex parent-offspring height differences across grandfathers' occupational categories remain best accounted for by Taiwan's rapidly expanding economy, substantial income equity and reductions in biases favoring sons over daughters. Adjustment for sub-group variation in parental height dimorphism should be considered in similar studies in the future. [Mh] Termos MeSH primário: Estatura/fisiologia [Mh] Termos MeSH secundário: Antropologia Física Feminino Seres Humanos Masculino Pais Fatores Sexuais Taiwan/epidemiologia [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 180214 [Lr] Data última revisão: 180214 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170429 [St] Status: MEDLINE [do] DOI: 10.1002/ajpa.23227

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[PMID]: 29236916 [Au] Autor: Regueiro MRKB; Nascimento WV; Parreira LC; Dantas RO [Ad] Endereço: Departamento de Oftalmologia, Otorrinolaringologia, Cirurgia de Cabeca e Pescoco, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, BR. [Ti] Título: Videofluoroscopic analysis of different volumes of liquid bolus swallowing in healthy individuals: comparison between height and sex. [So] Source: Clinics (Sao Paulo);72(11):693-697, 2017 Nov. [Is] ISSN: 1980-5322 [Cp] País de publicação: Brazil [La] Idioma: eng [Ab] Resumo: OBJECTIVE: The volume of swallowed bolus affects the pharyngeal transit duration. The sex and corporal height of individuals may likely influence this effect. The aim of this investigation was to determine the influence of sex and corporal height on the pharyngeal transit modification produced by the swallowed bolus volume. METHODS: Forty healthy volunteers, 20 men and 20 women, including tall (10 men and 10 women, corporal height: 1.71--2.07m) and short (10 men and 10 women, corporal height: 1.52--1.70m) persons, ranging in age between 20 and 50 years, were included in the study. Videofluoroscopic evaluation of swallowing was performed with the subjects in the sitting position. Each individual swallowed three 5 mL and three 10 mL boluses of liquid barium in a random sequence. The durations of oral transit, pharyngeal transit, pharyngeal clearance, hyoid movement, upper esophageal sphincter opening and oral-pharyngeal transit were evaluated. RESULTS: In men and women, and in taller and shorter individuals, the increase of the swallowed liquid bolus volume from 5 mL to 10 mL causes a faster transit of the bolus tail from the oral-pharyngeal transition to the upper esophageal sphincter and an increase in the duration of the upper esophageal sphincter opening, with similar alteration in men and women and in taller and shorter individuals. CONCLUSION: An increase in the swallowed liquid bolus volume from 5 mL to 10 mL causes a faster pharyngeal bolus transit and a longer bolus transit through the upper esophageal sphincter, with similar alterations in men and women and in shorter and taller individuals. [Mh] Termos MeSH primário: Estatura Deglutição/fisiologia Fatores Sexuais [Mh] Termos MeSH secundário: Adulto Feminino Fluoroscopia/métodos Voluntários Saudáveis Seres Humanos Masculino Meia-Idade Valores de Referência Gravação em Vídeo Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180129 [Lr] Data última revisão: 180129 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171214 [St] Status: MEDLINE

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