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[PMID]:28448500
[Au] Autor:Graff M; Scott RA; Justice AE; Young KL; Feitosa MF; Barata L; Winkler TW; Chu AY; Mahajan A; Hadley D; Xue L; Workalemahu T; Heard-Costa NL; den Hoed M; Ahluwalia TS; Qi Q; Ngwa JS; Renström F; Quaye L; Eicher JD; Hayes JE; Cornelis M; Kutalik Z; Lim E; Luan J; Huffman JE; Zhang W; Zhao W; Griffin PJ; Haller T; Ahmad S; Marques-Vidal PM; Bien S; Yengo L; Teumer A; Smith AV; Kumari M; Harder MN; Justesen JM; Kleber ME; Hollensted M; Lohman K; Rivera NV; Whitfield JB; Zhao JH; Stringham HM; Lyytikäinen LP; Huppertz C; Willemsen G; Peyrot WJ; CHARGE Consortium; EPIC-InterAct Consortium; PAGE Consortium
[Ad] Endereço:Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
[Ti] Título:Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.
[So] Source:PLoS Genet;13(4):e1006528, 2017 Apr.
[Is] ISSN:1553-7404
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.
[Mh] Termos MeSH primário: Adiposidade/genética
Dioxigenase FTO Dependente de alfa-Cetoglutarato/genética
Exercício
Obesidade/genética
[Mh] Termos MeSH secundário: Adiposidade/fisiologia
Índice de Massa Corporal
Epigenômica
Feminino
Predisposição Genética para Doença
Estudo de Associação Genômica Ampla
Genótipo
Seres Humanos
Masculino
Obesidade/fisiopatologia
Circunferência da Cintura
Relação Cintura-Quadril
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Nm] Nome de substância:
EC 1.14.11.33 (Alpha-Ketoglutarate-Dependent Dioxygenase FTO); EC 1.14.11.33 (FTO protein, human)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:180303
[Lr] Data última revisão:
180303
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pgen.1006528


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[PMID]:29261727
[Au] Autor:Sarrafzadegan N; Hassannejad R; Marateb HR; Talaei M; Sadeghi M; Roohafza HR; Masoudkabir F; Oveisgharan S; Mansourian M; Mohebian MR; Mañanas MA
[Ad] Endereço:Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
[Ti] Título:PARS risk charts: A 10-year study of risk assessment for cardiovascular diseases in Eastern Mediterranean Region.
[So] Source:PLoS One;12(12):e0189389, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study was designed to develop a risk assessment chart for the clinical management and prevention of the risk of cardiovascular disease (CVD) in Iranian population, which is vital for developing national prevention programs. The Isfahan Cohort Study (ICS) is a population-based prospective study of 6504 Iranian adults ≥35 years old, followed-up for ten years, from 2001 to 2010. Behavioral and cardiometabolic risk factors were examined every five years, while biennial follow-ups for the occurrence of the events was performed by phone calls or by verbal autopsy. Among these participants, 5432 (2784 women, 51.3%) were CVD free at baseline examination and had at least one follow-up. Cox proportional hazard regression was used to predict the risk of ischemic CVD events, including sudden cardiac death due to unstable angina, myocardial infarction, and stroke. The model fit statistics such as area under the receiver-operating characteristic (AUROC), calibration chi-square and the overall bias were used to assess the model performance. We also tested the Framingham model for comparison. Seven hundred and five CVD events occurred during 49452.8 person-years of follow-up. The event probabilities were calculated and presented color-coded on each gender-specific PARS chart. The AUROC and Harrell's C indices were 0.74 (95% CI, 0.72-0.76) and 0.73, respectively. In the calibration, the Nam-D'Agostino χ2 was 10.82 (p = 0.29). The overall bias of the proposed model was 95.60%. PARS model was also internally validated using cross-validation. The Android app and the Web-based risk assessment tool were also developed as to have an impact on public health. In comparison, the refitted and recalibrated Framingham models, estimated the CVD incidence with the overall bias of 149.60% and 128.23% for men, and 222.70% and 176.07% for women, respectively. In conclusion, the PARS risk assessment chart is a simple, accurate, and well-calibrated tool for predicting a 10-year risk of CVD occurrence in Iranian population and can be used in an attempt to develop national guidelines for the CVD management.
[Mh] Termos MeSH primário: Doenças Cardiovasculares/epidemiologia
Medição de Risco
[Mh] Termos MeSH secundário: Estudos de Coortes
Feminino
Seguimentos
Seres Humanos
Masculino
Região do Mediterrâneo/epidemiologia
Meia-Idade
Fatores de Risco
Relação Cintura-Quadril
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180218
[Lr] Data última revisão:
180218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189389


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[PMID]:29239470
[Au] Autor:Valmórbida JL; Goulart MR; Busnello FM; Pellanda LC
[Ad] Endereço:Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil.
[Ti] Título:Nutritional knowledge and body mass index: A cross-sectional study.
[So] Source:Rev Assoc Med Bras (1992);63(9):736-740, 2017 Sep.
[Is] ISSN:1806-9282
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To verify the knowledge about food and nutrition and its association with the nutritional status of obese patients with noncommunicable diseases (NCDs), and to identify the relationship between information sources and level of knowledge. METHOD: Cross-sectional study that included 263 outpatients of a cardiology referral hospital in Porto Alegre, Rio Grande do Sul, Brazil. The participants filled out a questionnaire on socioeconomic data and knowledge about food and nutrition and had their nutritional status evaluated by body mass index (BMI), waist circumference (WC) and waist-hip ratio (WHR). RESULTS: BMI showed a significant inverse association with the percentage of correct answers (p=0.002), as well as WC (p=0.000) and WHR (p<0.001). This was also true for education (p<0.001) and female gender (p=0.005) compared to males. More than 60% of patients reported using television and 23% reported using newspaper as sources of nutritional information. CONCLUSION: Our study revealed a significant association between BMI and the level of knowledge about foods, showing that there is need for more information on obesity-related NCDs for greater understanding by patients.
[Mh] Termos MeSH primário: Comportamento Alimentar
Conhecimentos, Atitudes e Prática em Saúde
Estado Nutricional
Obesidade
[Mh] Termos MeSH secundário: Índice de Massa Corporal
Doença Crônica
Estudos Transversais
Feminino
Seres Humanos
Masculino
Meia-Idade
Fatores de Risco
Fatores Socioeconômicos
Circunferência da Cintura
Relação Cintura-Quadril
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE


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[PMID]:29183889
[Au] Autor:Klaver M; de Blok CJM; Wiepjes CM; Nota NM; Dekker MJHJ; de Mutsert R; Schreiner T; Fisher AD; T'Sjoen G; den Heijer M
[Ad] Endereço:Department of Endocrinology and Center of Expertise on Gender DysphoriaVU University Medical Center, Amsterdam, the Netherlands.
[Ti] Título:Changes in regional body fat, lean body mass and body shape in trans persons using cross-sex hormonal therapy: results from a multicenter prospective study.
[So] Source:Eur J Endocrinol;178(2):165-173, 2018 Feb.
[Is] ISSN:1479-683X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Cross-sex hormonal therapy (CHT) in trans persons affects their total body fat and total lean body mass. However, it is unknown how separate body regions are affected and whether these changes alter body shape. Therefore, the aim of this study was to determine the effects on body fat and lean body mass in separate body regions and on body shape after one year of CHT. DESIGN AND METHODS: In a multicenter prospective study at university hospitals, 179 male-to-female gender dysphoric persons, referred to as transwomen, and 162 female-to-male gender dysphoric persons, referred to as transmen, were included. All underwent whole-body dual-energy X-ray absorptiometry and anthropometric measurements before and after one year of CHT. RESULTS: In transwomen, increases in body fat ranged from +18% (95% CI: 13%;23%) in the android region to +42% (95% CI: 37%;46%) in the leg region and +34% (95% CI: 29%;38%) in the gynoid region. In transmen, changes in body fat ranged from -16% (95% CI: -19;-14%) in the leg region and -14% in the gynoid region (95% CI: -16%;-12) to no change in the android region (+1%, 95% CI: -3%;5%). Waist-to-hip ratio (WHR) decreased in transwomen (-0.03, 95% CI: -0.04;-0.02) mainly due to an increase in hip circumference (+3.2 cm, 95% CI: 2.3;4.0). Transmen have a decrease in hip circumference (-1.9 cm, 95% CI: -3.1;-0.7) resulting in an increase in WHR (+0.01, 95% CI: 0.00;0.02). CONCLUSIONS: CHT causes a more feminine body fat distribution and a lower WHR in transwomen and a more masculine body fat distribution with a lower hip circumference in transmen.
[Mh] Termos MeSH primário: Composição Corporal/efeitos dos fármacos
Hormônios Esteroides Gonadais/administração & dosagem
Pessoas Transgênero
[Mh] Termos MeSH secundário: Absorciometria de Fóton
Adolescente
Adulto
Idoso
Antropometria
Distribuição da Gordura Corporal
Índice de Massa Corporal
Acetato de Ciproterona/administração & dosagem
Estradiol/administração & dosagem
Estradiol/sangue
Feminino
Hormônios Esteroides Gonadais/sangue
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Testosterona/administração & dosagem
Testosterona/sangue
Circunferência da Cintura/efeitos dos fármacos
Relação Cintura-Quadril
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Gonadal Steroid Hormones); 3XMK78S47O (Testosterone); 4KM2BN5JHF (Cyproterone Acetate); 4TI98Z838E (Estradiol)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180110
[Lr] Data última revisão:
180110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1530/EJE-17-0496


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[PMID]:28958344
[Au] Autor:Raynor HA; Davidson PG; Burns H; Nadelson MDH; Mesznik S; Uhley V; Moloney L
[Ti] Título:Medical Nutrition Therapy and Weight Loss Questions for the Evidence Analysis Library Prevention of Type 2 Diabetes Project: Systematic Reviews.
[So] Source:J Acad Nutr Diet;117(10):1578-1611, 2017 Oct.
[Is] ISSN:2212-2672
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Eleven recommendations, based on systematic reviews, were developed for the Evidence Analysis Library's prevention of type 2 diabetes project. Two recommendations, medical nutrition therapy (MNT) and weight loss, were rated strong. OBJECTIVE: Present the basis of systematic reviews for MNT and weight loss recommendations. METHODS: Literature searches using Medline were conducted to identify studies that met eligibility criteria. The MNT literature search covered a time span of 1995 to 2012, the weight loss literature search covered 2008 to 2012 due to inclusion of a Cochrane Review meta-analysis of randomized controlled trials (RCTs) published in 2008. Eligibility criteria for inclusion of articles included original research using higher-quality study designs (ie, RCTs, case control, cohort, crossover, and nonrandomized trials) with participants aged >18 years and meeting prediabetes or metabolic syndrome diagnostic criteria. MNT was defined as individualized and delivered by a registered dietitian nutritionist or international equivalent and length of weight loss interventions was ≥3 months. MAIN OUTCOME MEASURES: Two-hour postprandial blood glucose level, glycated hemoglobin level, albumin-to-creatinine ratio (metabolic syndrome samples only), fasting blood glucose level, high-density lipoprotein cholesterol level, systolic and diastolic blood pressure, triglyceride levels, urinary albumin excretion rate (metabolic syndrome samples only), waist circumference (WC), and waist-to-hip ratio were evaluated. RESULTS: For MNT, 11 publications were included, with all 11 using an RCT study design and 10 including participants with prediabetes. A majority of publications reported significant improvements in glycemic outcomes, WC, and blood pressure. For weight loss, 28 publications were identified, with one meta-analysis (only included RCTs) and 20 publications using an RCT study design, with the meta-analysis and 10 RCTs including participants with prediabetes. A majority of publications reported significant improvements in glycemic outcomes, triglyceride level, WC, and blood pressure. CONCLUSIONS: Systematic reviews provided strong evidence that MNT and weight loss alter clinical parameters in ways that should reduce the risk of developing type 2 diabetes.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/prevenção & controle
Terapia Nutricional/métodos
Comportamento de Redução do Risco
Perda de Peso
[Mh] Termos MeSH secundário: Glicemia/análise
Diabetes Mellitus Tipo 2/etiologia
Hemoglobina A Glicada/análise
Seres Humanos
Ensaios Clínicos Controlados Aleatórios como Assunto
Literatura de Revisão como Assunto
Fatores de Risco
Circunferência da Cintura
Relação Cintura-Quadril
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Glycated Hemoglobin A); 0 (hemoglobin A1c protein, human)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170930
[St] Status:MEDLINE


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[PMID]:28830368
[Au] Autor:Bienertová-Vasku J; Zlámal F; Pohoralá A; Mikes O; Goldbergová-Pávková M; Novák J; Splíchal Z; Pikhart H
[Ad] Endereço:Research Centre for Toxic Compounds in the Environment, Faculty of Sciences, Masaryk University, Kamenice A29, Brno, Czech Republic. vasku.julie@seznam.cz.
[Ti] Título:Allelic variants in vitamin D receptor gene are associated with adiposity measures in the central-European population.
[So] Source:BMC Med Genet;18(1):90, 2017 Aug 22.
[Is] ISSN:1471-2350
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: There is an increasing body of evidence suggesting that vitamin D is involved in ethiopathogenesis of obesity and therefore the aim of the study was to investigate whether 5 selected SNPs in VDR (vitamin D receptor) gene are associated also with anthropometry in the obese and non-obese Central-European population. METHODS: A total of 882 Central European Caucasian individuals of Czech origin were recruited (n = 882, 232 M/650 F) and weight, height, BMI, lean body mass, fat mass, body fat, waist and hip circumference, waist-hip ratio (WHR) and skinfold thickness were measured. Univariate and multivariate models were constructed in order to investigate the relationship between anthropometry and VDR polymorphisms. RESULTS: In the univariate modeling, the CC genotype of FokI SNP was associated with reduced waist circumference (ß = -3.48; 95%CI:-7.11;0.15; p = 0.060), sum of skin fold thickness (ß = -6.53, 95% CI: -12.96;-0.11; p = 0.046) as well as total % of body fat (ß = -3.14, 95% CI: -5.18;-1.09; p = 0.003) compared to TT genotype. The AC genotype of ApaI SNP was associated with reduced waist circumference compared to AA genotype (ß = -4.37, 95% CI: -7.54;-1.20; p = 0.007). GG genotype of EcoRV SNP was associated with reduced sum of skin fold thickness compared to AA genotype (ß = -7.77, 95% CI: -14.34;-1.21; p = 0.020). In the multivariate modelling, multiple significant associations of VDR with investigated traits were observed, too. CONCLUSION: Our study suggests that genetic variability in the VDR region may be an important factor influencing anthropometric characteristics associated with obesity.
[Mh] Termos MeSH primário: Adiposidade/genética
Grupo com Ancestrais do Continente Europeu/genética
Polimorfismo de Nucleotídeo Único
Receptores de Calcitriol/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Alelos
Índice de Massa Corporal
Feminino
Técnicas de Genotipagem
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Análise Multivariada
Obesidade/sangue
Obesidade/genética
Receptores de Calcitriol/metabolismo
Circunferência da Cintura
Relação Cintura-Quadril
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Calcitriol); 0 (VDR protein, human)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1186/s12881-017-0454-z


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[PMID]:28820080
[Au] Autor:Ribeiro RV; Hirani V; Senior AM; Gosby AK; Cumming RG; Blyth FM; Naganathan V; Waite LM; Handelsman DJ; Kendig H; Seibel MJ; Simpson SJ; Stanaway F; Allman-Farinelli M; Le Couteur DG
[Ad] Endereço:1School of Life and Environmental Sciences,Charles Perkins Centre,University of Sydney,Sydney,NSW, 2006,Australia.
[Ti] Título:Diet quality and its implications on the cardio-metabolic, physical and general health of older men: the Concord Health and Ageing in Men Project (CHAMP).
[So] Source:Br J Nutr;118(2):130-143, 2017 Jul.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The revised Dietary Guideline Index (DGI-2013) scores individuals' diets according to their compliance with the Australian Dietary Guideline (ADG). This cross-sectional study assesses the diet quality of 794 community-dwelling men aged 74 years and older, living in Sydney, Australia participating in the Concord Health and Ageing in Men Project; it also examines sociodemographic and lifestyle factors associated with DGI-2013 scores; it studies associations between DGI-2103 scores and the following measures: homoeostasis model assessment - insulin resistance, LDL-cholesterol, HDL-cholesterol, TAG, blood pressure, waist:hip ratio, BMI, number of co-morbidities and medications and frailty status while also accounting for the effect of ethnicity in these relationships. Median DGI-2013 score was 93·7 (54·4, 121·2); most individuals failed to meet recommendations for vegetables, dairy products and alternatives, added sugar, unsaturated fat and SFA, fluid and discretionary foods. Lower education, income, physical activity levels and smoking were associated with low scores. After adjustments for confounders, high DGI-2013 scores were associated with lower HDL-cholesterol, lower waist:hip ratios and lower probability of being frail. Proxies of good health (fewer co-morbidities and medications) were not associated with better compliance to the ADG. However, in participants with a Mediterranean background, low DGI-2013 scores were not generally associated with poorer health. Older men demonstrated poor diet quality as assessed by the DGI-2013, and the association between dietary guidelines and health measures and indices may be influenced by ethnic background.
[Mh] Termos MeSH primário: Envelhecimento/fisiologia
Dieta
Nível de Saúde
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Austrália
Pressão Sanguínea
Índice de Massa Corporal
Colesterol/sangue
HDL-Colesterol/sangue
Estudos Transversais
Grupos Étnicos
Idoso Fragilizado
Grécia/etnologia
Seres Humanos
Vida Independente
Resistência à Insulina
Itália/etnologia
Estilo de Vida
Masculino
Política Nutricional
Triglicerídeos/sangue
Relação Cintura-Quadril
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cholesterol, HDL); 0 (Triglycerides); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170819
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517001738


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[PMID]:28759582
[Au] Autor:Grant JF; Chittleborough CR; Shi Z; Taylor AW
[Ad] Endereço:School of Public Health and Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia.
[Ti] Título:The association between A Body Shape Index and mortality: Results from an Australian cohort.
[So] Source:PLoS One;12(7):e0181244, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:It is well recognised that obesity increases the risk of premature death. A Body Shape Index (ABSI) is a formula that uses waist circumference (WC), body mass index (BMI) and height to predict risk of premature mortality, where a high score (Quartile 4) indicates that a person's WC is more than expected given their height and weight. Our study examines the association between ABSI quartiles and all-cause-, cardiovascular- and cancer-related mortality, and primary cause of death. Self-reported demographic and biomedically measured health-related risk factor and weight data was from the baseline stage of the North West Adelaide Health Study (1999-2003, n = 4056), a longitudinal cohort of Australian adults. Death-related information was obtained from the National Death Index. Primary cause of death across ABSI quartiles was examined. The association between mortality and ABSI (quartile and continuous scores) was investigated using a Cox proportional hazards survival model and adjusting for socioeconomic, and self-reported and biomedical risk factors. The proportion of all three types of mortality steadily increased from ABSI Quartile 1 through to Quartile 4. After adjusting for demographic and health-related risk factors, the risk of all-cause mortality was higher for people in ABSI Quartile 4 (HR 2.64, 95% CI 01.56-4.47), and ABSI Quartile 3 (HR 1.95, 95% CI 1.15-3.33), with a moderate association for the continuous ABSI score (HR 1.32, 95% CI 1.18-1.48). ABSI is therefore positively associated with mortality in Australian adults. Different combined measures of obesity such as the ABSI are useful in examining mortality risk.
[Mh] Termos MeSH primário: Antropometria/métodos
Tamanho Corporal
Mortalidade
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Austrália
Índice de Massa Corporal
Peso Corporal
Feminino
Seres Humanos
Estudos Longitudinais
Masculino
Meia-Idade
Obesidade/diagnóstico
Sistema de Registros
Fatores de Risco
Circunferência da Cintura
Relação Cintura-Quadril
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181244


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[PMID]:28749953
[Au] Autor:Winkler TW; Justice AE; Cupples LA; Kronenberg F; Kutalik Z; Heid IM; GIANT consortium
[Ad] Endereço:Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
[Ti] Título:Approaches to detect genetic effects that differ between two strata in genome-wide meta-analyses: Recommendations based on a systematic evaluation.
[So] Source:PLoS One;12(7):e0181038, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Genome-wide association meta-analyses (GWAMAs) conducted separately by two strata have identified differences in genetic effects between strata, such as sex-differences for body fat distribution. However, there are several approaches to identify such differences and an uncertainty which approach to use. Assuming the availability of stratified GWAMA results, we compare various approaches to identify between-strata differences in genetic effects. We evaluate type I error and power via simulations and analytical comparisons for different scenarios of strata designs and for different types of between-strata differences. For strata of equal size, we find that the genome-wide test for difference without any filtering is the best approach to detect stratum-specific genetic effects with opposite directions, while filtering for overall association followed by the difference test is best to identify effects that are predominant in one stratum. When there is no a priori hypothesis on the type of difference, a combination of both approaches can be recommended. Some approaches violate type I error control when conducted in the same data set. For strata of unequal size, the best approach depends on whether the genetic effect is predominant in the larger or in the smaller stratum. Based on real data from GIANT (>175 000 individuals), we exemplify the impact of the approaches on the detection of sex-differences for body fat distribution (identifying up to 10 loci). Our recommendations provide tangible guidelines for future GWAMAs that aim at identifying between-strata differences. A better understanding of such effects will help pinpoint the underlying mechanisms.
[Mh] Termos MeSH primário: Estudo de Associação Genômica Ampla
[Mh] Termos MeSH secundário: Simulação por Computador
Feminino
Seres Humanos
Masculino
Relação Cintura-Quadril
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181038


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[PMID]:28723954
[Au] Autor:Campbell R; Tasevska N; Jackson KG; Sagi-Kiss V; di Paolo N; Mindell JS; Lister SJ; Khaw KT; Kuhnle GGC
[Ad] Endereço:Department of Food & Nutritional Sciences, University of Reading, Reading, United Kingdom.
[Ti] Título:Association between urinary biomarkers of total sugars intake and measures of obesity in a cross-sectional study.
[So] Source:PLoS One;12(7):e0179508, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Obesity is an important modifiable risk factor for chronic diseases. While there is increasing focus on the role of dietary sugars, there remains a paucity of data establishing the association between sugar intake and obesity in the general public. The objective of this study was to investigate associations of estimated sugar intake with odds for obesity in a representative sample of English adults. We used data from 434 participants of the 2005 Health Survey of England. Biomarkers for total sugar intake were measured in 24 h urine samples and used to estimate intake. Linear and logistic regression analyses were used to investigate associations between biomarker-based estimated intake and measures of obesity (body mass intake (BMI), waist circumference and waist-to-hip ratio) and obesity risk, respectively. Estimated sugar intake was significantly associated with BMI, waist circumference and waist-to-hip ratio; these associations remained significant after adjustment for estimated protein intake as a marker of non-sugar energy intake. Estimated sugar intake was also associated with increased odds for obesity based on BMI (OR 1.02; 95%CI 1.00-1.04 per 10g), waist-circumference (1.03; 1.01-1.05) and waist-to-hip ratio (1.04; 1.02-1.06); all OR estimates remained significant after adjusting for estimated protein intake. Our results strongly support positive associations between total sugar intake, measures of obesity and likelihood of being obese. It is the first time that such an association has been shown in a nationally-representative sample of the general population using a validated biomarker. This biomarker could be used to monitor the efficacy of public health interventions to reduce sugar intake.
[Mh] Termos MeSH primário: Sacarose na Dieta/urina
Obesidade/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Biomarcadores/urina
Índice de Massa Corporal
Estudos Transversais
Ingestão de Energia
Inglaterra
Feminino
Inquéritos Epidemiológicos
Seres Humanos
Masculino
Meia-Idade
Obesidade/urina
Fatores de Risco
Circunferência da Cintura/fisiologia
Relação Cintura-Quadril
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Dietary Sucrose)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179508



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