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[PMID]:28464481
[Au] Autor:Hack CC; Stoll MJ; Jud SM; Heusinger K; Adler W; Haeberle L; Ganslandt T; Heindl F; Schulz-Wendtland R; Cavallaro A; Uder M; Beckmann MW; Fasching PA; Bayer CM
[Ad] Endereço:Department of Gynecology and Obstetrics, Erlangen University Hospital, Comprehensive Cancer Center Erlangen/European Metropolitan Area Nuremberg (CCC ER-EMN), Erlangen, Germany.
[Ti] Título:Correlation of mammographic density and serum calcium levels in patients with primary breast cancer.
[So] Source:Cancer Med;6(6):1473-1481, 2017 Jun.
[Is] ISSN:2045-7634
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Percentage mammographic breast density (PMD) is one of the most important risk factors for breast cancer (BC). Calcium, vitamin D, bisphosphonates, and denosumab have been considered and partly confirmed as factors potentially influencing the risk of BC. This retrospective observational study investigated the association between serum calcium level and PMD. A total of 982 BC patients identified in the research database at the University Breast Center for Franconia with unilateral BC, calcium and albumin values, and mammogram at the time of first diagnosis were included. PMD was assessed, using a semiautomated method by two readers. Linear regression analyses were conducted to investigate the impact on PMD of the parameters of serum calcium level adjusted for albumin level, and well-known clinical predictors such as age, body mass index (BMI), menopausal status and confounder for serum calcium like season in which the BC was diagnosed. Increased calcium levels were associated with reduced PMD (P = 0.024). Furthermore, PMD was inversely associated with BMI (P < 0.001) and age (P < 0.001). There was also an association between PMD and menopausal status (P < 0.001). The goodness-of-fit of the regression model was moderate. This is the first study assessing the association between serum calcium level and PMD. An inverse association with adjusted serum calcium levels was observed. These findings add to previously published data relating to vitamin D, bisphosphonates, denosumab, and the RANK/RANKL signaling pathway in breast cancer risk and prevention.
[Mh] Termos MeSH primário: Densidade da Mama
Neoplasias da Mama/sangue
Neoplasias da Mama/diagnóstico por imagem
Cálcio/sangue
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Mamografia
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
SY7Q814VUP (Calcium)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1002/cam4.1066


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[PMID]:29182397
[Au] Autor:Lecler A; Dunant A; Delaloge S; Wehrer D; Moussa T; Caron O; Balleyguier C
[Ad] Endereço:1 Department of Radiology, Fondation Ophtalmologique Rothschild , Fondation Ophtalmologique Rothschild , Paris , France.
[Ti] Título:Breast tissue density change after oophorectomy in BRCA mutation carrier patients using visual and volumetric analysis.
[So] Source:Br J Radiol;91(1083):20170163, 2018 Feb.
[Is] ISSN:1748-880X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: BRCA1/2 mutations account for 30-50% of hereditary breast cancers and bilateral oophorectomy is associated with a reduced risk of breast cancer in these patients. Breast density is a well-established breast cancer risk factor and is also associated with increased risk in BRCA carriers. The aim of the study was to evaluate the impact of oophorectomy on mammographic breast density and to assess which method of breast density assessment is more sensitive to change over time. METHODS: Retrospective study of 50 BRCA1/2 patients who underwent bilateral oophorectomy and had at least a baseline and post-surgery mammogram. Mammographic breast density was determined by Volpara and consensus visual assessment by two radiologists. The primary endpoint was change in density between baseline and the first mammogram post-surgery. RESULTS: At baseline, there was a non-significant trend for decreased density with increasing age. Volumetric breast density (VBD) significantly decreased after oophorectomy from a median VBD of 12.5% at baseline to 10.2% post-surgery which was driven by a reduction in fibroglandular volume. There was a higher absolute decrease in VBD in patients aged between 40-50 (p < 0.01). Using Volpara Density Grades (analogous to BI-RADS 4th edition density categories), 84% of females displayed a decrease in density category over the study period compared to only 76% using the radiologists' visual classification (p < 0.001) Conclusion: Oophorectomy is associated with a decrease in breast density and younger patients exhibit a larger absolute decrease. Volpara is more sensitive to identify change over time compared to visual assessment. Advances in knowledge: Oophorectomy is associated with a significant decrease in VBD in patients with BRCA mutations and Volpara Density Grades were more sensitive to identify decreases in density compared to visually assessed BI-RADS categories. Decreases in breast density following oophorectomy surgery in BRCA patients may be one of the mechanisms contributing to the observed decreased breast cancer risk after surgery. However, further studies are needed to investigate the relationship between breast density, oophorectomy and breast cancer risk in BRCA patients.
[Mh] Termos MeSH primário: Densidade da Mama
Neoplasias da Mama/genética
Genes BRCA1
Genes BRCA2
Ovariectomia
[Mh] Termos MeSH secundário: Adulto
Algoritmos
Neoplasias da Mama/diagnóstico por imagem
Feminino
Seres Humanos
Interpretação de Imagem Assistida por Computador
Estudos Longitudinais
Mamografia
Meia-Idade
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1259/bjr.20170163


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[PMID]:27776557
[Au] Autor:Huo CW; Waltham M; Khoo C; Fox SB; Hill P; Chen S; Chew GL; Price JT; Nguyen CH; Williams ED; Henderson M; Thompson EW; Britt KL
[Ad] Endereço:Department of Surgery, University of Melbourne, St Vincent's Hospital, Melbourne, VIC, 3156, Australia.
[Ti] Título:Mammographically dense human breast tissue stimulates MCF10DCIS.com progression to invasive lesions and metastasis.
[So] Source:Breast Cancer Res;18(1):106, 2016 10 25.
[Is] ISSN:1465-542X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: High mammographic density (HMD) not only confers a significantly increased risk of breast cancer (BC) but also is associated with BCs of more advanced stages. However, it is unclear whether BC progression and metastasis are stimulated by HMD. We investigated whether patient-derived HMD breast tissue could stimulate the progression of MCF10DCIS.com cells compared with patient-matched low mammographic density (LMD) tissue. METHODS: Sterile breast specimens were obtained immediately after prophylactic mastectomy from high-risk women (n = 10). HMD and LMD regions of each specimen were resected under radiological guidance. Human MCF10DCIS.com cells, a model of ductal carcinoma in situ (DCIS), were implanted into silicone biochambers in the groins of severe combined immunodeficiency mice, either alone or with matched LMD or HMD tissue (1:1), and maintained for 6 weeks. We assessed biochamber weight as a measure of primary tumour growth, histological grade of the biochamber material, circulating tumour cells and metastatic burden by luciferase and histology. All statistical tests were two-sided. RESULTS: HMD breast tissue led to increased primary tumour take, increased biochamber weight and increased proportions of high-grade DCIS and grade 3 invasive BCs compared with LMD. This correlated with an increased metastatic burden in the mice co-implanted with HMD tissue. CONCLUSIONS: Our study is the first to explore the direct effect of HMD and LMD human breast tissue on the progression and dissemination of BC cells in vivo. The results suggest that HMD status should be a consideration in decision-making for management of patients with DCIS lesions.
[Mh] Termos MeSH primário: Densidade da Mama
Neoplasias da Mama/diagnóstico por imagem
Neoplasias da Mama/patologia
Mamografia
[Mh] Termos MeSH secundário: Adulto
Animais
Biomarcadores Tumorais
Neoplasias da Mama/cirurgia
Linhagem Celular Tumoral
Modelos Animais de Doenças
Progressão da Doença
Feminino
Xenoenxertos
Seres Humanos
Mamografia/métodos
Camundongos
Meia-Idade
Mutação
Invasividade Neoplásica
Metástase Neoplásica
Mastectomia Profilática
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180126
[Lr] Data última revisão:
180126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


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[PMID]:28843166
[Au] Autor:García-Pérez J; Pollán M; Pérez-Gómez B; González-Sánchez M; Cortés Barragán RA; Maqueda Blasco J; González-Galarzo MC; Alba MÁ; van der Haar R; Casas S; Vicente C; Medina P; Ederra M; Santamariña C; Moreno MP; Casanova F; Pedraz-Pingarrón C; Moreo P; Ascunce N; García M; Salas-Trejo D; Sánchez-Contador C; Llobet R; Lope V
[Ad] Endereço:Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain; Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Spain. Electronic address: jgarcia@isciii.es.
[Ti] Título:Occupation and mammographic density: A population-based study (DDM-Occup).
[So] Source:Environ Res;159:355-361, 2017 11.
[Is] ISSN:1096-0953
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: High mammographic density is one of the main risk factors for breast cancer. Although several occupations have been associated with breast cancer, there are no previous occupational studies exploring the association with mammographic density. Our objective was to identify occupations associated with high mammographic density in Spanish female workers. METHODS: We conducted a population-based cross-sectional study of occupational determinants of high mammographic density in Spain, based on 1476 women, aged 45-68 years, recruited from seven screening centers within the Spanish Breast Cancer Screening Program network. Reproductive, family, personal, and occupational history data were collected. The latest occupation of each woman was collected and coded according to the 1994 National Classification of Occupations. Mammographic density was assessed from the cranio-caudal mammogram of the left breast using a semi-automated computer-assisted tool. Association between mammographic density and occupation was evaluated by using mixed linear regression models, using log-transformed percentage of mammographic density as dependent variable. Models were adjusted for age, body mass index, menopausal status, parity, smoking, alcohol intake, educational level, type of mammography, first-degree relative with breast cancer, and hormonal replacement therapy use. Screening center and professional reader were included as random effects terms. RESULTS: Mammographic density was higher, although non-statistically significant, among secondary school teachers (e = 1.41; 95%CI = 0.98-2.03) and nurses (e = 1.23; 95%CI = 0.96-1.59), whereas workers engaged in the care of people (e = 0.81; 95%CI = 0.66-1.00) and housewives (e = 0.87; 95%CI = 0.79-0.95) showed an inverse association with mammographic density. A positive trend for every 5 years working as secondary school teachers was also detected (p-value = 0.035). CONCLUSIONS: Nurses and secondary school teachers were the occupations with the highest mammographic density in our study, showing the latter a positive trend with duration of employment. Future studies are necessary to confirm if these results are due to chance or are the result of a true association whose causal hypothesis is, for the moment, unknown.
[Mh] Termos MeSH primário: Densidade da Mama
Ocupações/classificação
[Mh] Termos MeSH secundário: Idoso
Estudos Transversais
Feminino
Seres Humanos
Modelos Lineares
Mamografia
Meia-Idade
Espanha
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170827
[St] Status:MEDLINE


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[PMID]:28816987
[Au] Autor:Ko KH; Jung HK; Kim I
[Ad] Endereço:Department of Radiology, CHA Bundang Medical Center, CHA University, School of Medicine, Gyeonggi-do, South Korea.
[Ti] Título:Analysis of background parenchymal echogenicity on breast ultrasound: Correlation with mammographic breast density and background parenchymal enhancement on magnetic resonance imaging.
[So] Source:Medicine (Baltimore);96(33):e7850, 2017 Aug.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to analyze the background parenchymal echotexture (BP echo) on breast ultrasound in detail and to evaluate the relation BP echo with menopausal status. In addition, we correlated BP echo with mammographic breast density (MGD) and background parenchymal enhancement (BPE) on magnetic resonance imaging (MRI).The institutional review board of our hospital approved this retrospective study, and the requirement of informed consent was waived. We studied 138 women (mean age 51.6 years, range from 26 to 79 years) with newly diagnosed invasive breast cancer, who had performed preoperative mammography, ultrasound, and MR from June 2013 to June 2015. BP echo was classified as homogeneous and heterogeneous according to the BI-RADS US lexicon. MGD was described into fatty, scattered, heterogeneously dense, and extremely dense. BPE was categorized as minimal, mild, moderate, and marked. The relationship between the BP echo and menopausal status was investigated. Associations between the degree of BP echo with MGD grades and BPE grades were also evaluated.Of the 138 women, 74 (54%) were premenopausal and 64 (46%) were postmenopausal. Premenopausal women were more likely to have heterogeneous BP echo (60/74, 81%) compared with postmenopausal women (10/64, 16%) (P = .000). BP echo showed significant correlation with BPE in both premenopausal and postmenopausal women (P = .000). However, MGD showed no significant correlation with BP echo or BPE, regardless of menopausal states. In the postmenopausal group, 70% women (21/30) with dense MGD showed homogeneous BP echo and 77% women (23/30) with dense MGD showed nondense BPE.In conclusion, we demonstrated that the BP echo was influenced by menopausal status. Our data support the concept that BP echo is influenced by breast hormonal changes. Because there was a significant association between BP echo and BPE in pre- and post-menopausal women, the BP echo might be a good predictor for BPE.
[Mh] Termos MeSH primário: Densidade da Mama/fisiologia
Mama/patologia
Interpretação de Imagem Assistida por Computador/métodos
Imagem por Ressonância Magnética/métodos
Ultrassonografia Mamária/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Menopausa/fisiologia
Meia-Idade
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007850


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[PMID]:28796548
[Au] Autor:Irshad A; Leddy R; Lewis M; Cluver A; Ackerman S; Pavic D; Collins H
[Ad] Endereço:1 Department of Radiology, Medical University of South Carolina, 169 Ashley Ave, Charleston, SC 29425.
[Ti] Título:Changes in Breast Density Reporting Patterns of Radiologists After Publication of the 5th Edition BI-RADS Guidelines: A Single Institution Experience.
[So] Source:AJR Am J Roentgenol;209(4):943-948, 2017 Oct.
[Is] ISSN:1546-3141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The objective of our study was to determine the impact of 5th edition BI-RADS breast density assessment guidelines on density reporting patterns in our clinical practice. MATERIALS AND METHODS: PenRad reporting system was used to collect mammographic breast density data reported by five radiologists: 16,907 density assignments using 5th edition BI-RADS guidelines were compared with 19,066 density assessments using 4th edition guidelines. Changes in the density assessment pattern were noted between the 4th and 5th edition guidelines, and agreement in density distribution was compared using the intraclass correlation coefficient. A chi-square analysis was conducted for each reader to examine the change in the proportion of dense versus nondense assignments and on each category type to examine specific changes in proportion of density assignments from the 4th to the 5th edition. All reported p values are two-sided, and statistical significance was considered at the p < 0.001 threshold. RESULTS: Using the 5th edition, there was an overall 5.0% decrease in fatty assessments (p < 0.001), 2.8% increase in scattered densities (p < 0.001), 2.6% increase in heterogeneously dense (p < 0.001), and 0.4% decrease in extremely dense assessments (p = 0.15). Comparing the dense with nondense categories, there was a 2.3% overall increase in the dense assessments (p < 0.001) using 5th edition guidelines, mainly in the heterogeneously dense category. Two radiologists showed increased dense assessments (p < 0.001) using the 5th edition, and three radiologists showed no change (p = 0.39, 0.67, and 0.76). CONCLUSION: There was an overall increase in the dense assessments using the 5th edition, but individual radiologists in our clinical practice showed a variable adaptation to new guidelines.
[Mh] Termos MeSH primário: Densidade da Mama
Mamografia
Guias de Prática Clínica como Assunto
Padrões de Prática Médica/normas
Radiologia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Meia-Idade
Projetos de Pesquisa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170811
[St] Status:MEDLINE
[do] DOI:10.2214/AJR.16.17518


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[PMID]:28767986
[Au] Autor:Mauro Secco J; Elias S; Valletta de Carvalho C; Dale Cotrim Guerreiro da Silva I; Jung de Campos K; Facina G; Celso Pinto Nazário A
[Ad] Endereço:MD, PhD. Researcher, Universidade Federal de São Paulo (Unifesp), São Paulo (SP), and Adjunct Professor, Universidade Federal do Amapá (Unifap), Amapá (AP), Brazil.
[Ti] Título:Mammographic density among indigenous women in forested areas in the state of Amapá, Brazil: a cross-sectional study.
[So] Source:Sao Paulo Med J;135(4):355-362, 2017 Jul-Aug.
[Is] ISSN:1806-9460
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:CONTEXT AND OBJECTIVE:: There is no register of breast cancer cases among indigenous populations in Brazil. The objective here was to evaluate the association of clinical and demographic characteristics with mammographic density among indigenous women. DESIGN AND SETTING:: Cross-sectional analytical study conducted in indigenous territories in the state of Amapá, Brazil. METHODS:: Women were recruited from three indigenous territories and underwent bilateral mammography and blood collection for hormonal analysis. They were interviewed with the aid of an interpreter. Mammographic density was calculated using computer assistance, and was expressed as dense or non-dense. RESULTS:: A total of 137 indigenous women were included in this study, with an average age of 50.4 years, and an average age at the menarche of 12.8 years. Half (50.3%) of the 137 participants had not reached the menopause at the time of this study. The women had had an average of 8.7 children, and only two had never breastfed. The average body mass index of the population as a whole was 25.1 kg/m2. The mammographic evaluation showed that 82% of women had non-dense breasts. The clinical characteristics associated with mammographic density were age (P = 0.0001), follicle-stimulating hormone (FSH) (P < 0.001) and estrogen levels (P < 0.01). CONCLUSIONS:: The majority of the indigenous women had non-dense breasts. Age, menopausal status and FSH and estrogen levels were associated with mammographic density.
[Mh] Termos MeSH primário: Densidade da Mama/fisiologia
Índios Sul-Americanos/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adulto
Brasil
Estudos Transversais
Estrogênios/sangue
Feminino
Hormônio Foliculoestimulante/sangue
Florestas
Seres Humanos
Mamografia
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Estrogens); 9002-68-0 (Follicle Stimulating Hormone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE


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[PMID]:28719794
[Au] Autor:Dung Yun Trieu P; Mello-Thoms C; Peat JK; Doan Do T; Brennan PC
[Ad] Endereço:1 The University of Sydney, Lidcombe, New South Wales, Australia.
[Ti] Título:Associations of Breast Density With Demographic, Reproductive, and Lifestyle Factors in a Developing Southeast Asian Population.
[So] Source:Asia Pac J Public Health;29(5):377-387, 2017 Jul.
[Is] ISSN:1941-2479
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to investigate how breast density interacted with demographic, reproductive, and lifestyle features among Vietnamese women. Mammographic density and established risk factors for breast cancer were collected from 1651 women (345 cancer cases and 1306 normal cases) in Vietnam. The association of breast density categories with potential risk factors was investigated using Spearman's test for continuous variables and χ tests for categorical variables. Independent factors associated with high breast density and breast cancer in specific density groupings were assessed using logistic regression. Results showed that high breast density was significantly associated with young age, low body mass index, low number of children, early age at having the last child, premenopausal status, and increased vegetable consumption. Reproductive factors were key agents associated with breast cancer for women with high breast density, which was not so evident for women with low breast density.
[Mh] Termos MeSH primário: Densidade da Mama
Neoplasias da Mama/epidemiologia
Estilo de Vida
História Reprodutiva
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Estudos de Casos e Controles
Feminino
Seres Humanos
Mamografia
Meia-Idade
Estudos Prospectivos
Fatores de Risco
Vietnã/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.1177/1010539517717313


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[PMID]:28707989
[Au] Autor:Abdolell M; Tsuruda KM; Brown P; Caines JS; Iles SE
[Ad] Endereço:1 Department of Diagnostic Imaging, Nova Scotia Health Authority , Halifax , NS, Canada.
[Ti] Título:Breast density scales: the metric matters.
[So] Source:Br J Radiol;90(1078):20170307, 2017 Oct.
[Is] ISSN:1748-880X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Measures of percent mammographic density (PMD) are often categorized using various density scales. The purpose of this study was to examine information loss associated with the use of categorical density scales. METHODS: Baseline PMD was assessed at 1% precision for 2,374 females. The data were used to create 21-category, 4-category and 2-category density scales. R-squared and root mean square error were used to evaluate the effect of categorizing PMD. The area under the receiver operator characteristic curves were compared between cancer risk models employing solely categorical PMD scales and solely baseline PMD for a subset of females (424 cases, 848 controls). RESULTS: R-squared value decreased from 1.00 (1% PMD) to 0.56 (2-category scale), while root mean square error increased from 0.00 (1% PMD) to 10.83 (2-category scale). The area under the receiver operator characteristic curve decreased from 0.64 for a cancer risk model using 1% PMD to 0.58 for a risk model using a 21-category density scale (p < 0.0001), 0.55 for a 4-category Breast Imaging, Reporting and Data System-like scale (p < 0.0001) and 0.50 for a 2-category Breast Imaging, Reporting and Data System-like scale (high vs low) (p < 0.0001). CONCLUSION: Categorizing PMD measures into categorical density scales leads to a significant loss of information. Indeed, a simple high versus low split of PMD using a 50% cut point yields a cancer risk model with no discriminatory power. Advances in knowledge: Use of categorical mammographic density scales rather than continuous percent mammographic density measures leads to significant loss of information. Breast cancer risk models using categorical mammographic density scales perform more poorly than models using continuous PMD measures.
[Mh] Termos MeSH primário: Densidade da Mama
Neoplasias da Mama/diagnóstico por imagem
Neoplasias da Mama/patologia
Mamografia
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE
[do] DOI:10.1259/bjr.20170307


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[PMID]:28670157
[Au] Autor:Kim YJ; Lee EH; Jun JK; Shin DR; Park YM; Kim HW; Kim Y; Kim KW; Lim HS; Park JS; Kim HJ; Jo HM; Alliance for Breast Cancer Screening in Korea (ABCS-K)
[Ad] Endereço:Department of Radiology, Konyang University Hospital, Konyang University College of Medicine, Daejeon 35365, Korea.
[Ti] Título:Analysis of Participant Factors That Affect the Diagnostic Performance of Screening Mammography: A Report of the Alliance for Breast Cancer Screening in Korea.
[So] Source:Korean J Radiol;18(4):624-631, 2017 Jul-Aug.
[Is] ISSN:2005-8330
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To analyze participant factors that affect the diagnostic performance of screening mammography. MATERIALS AND METHODS: We enrolled 128756 cases from 10 hospitals between 2005 and 2010. We analyzed recall rate, cancer detection rate (CDR) per 1000 examinations, positive predictive value (PPV), sensitivity, specificity, false positive rate (FPR), and interval cancer rate (ICR) per 1000 negative examinations according to participant factors including age, breast density, and number of visit to the same institution, and adjusted for confounding variables. RESULTS: Increasing age improved recall rates (27.4% in 40's, 17.5% in 50's, 11.1% in 60's, and 8.6% in 70's), CDR (2.7, 3.2, 2.0, and 2.4), PPV (1.0, 1.8, 1.8, and 2.8%), sensitivity (81.3, 88.8, 90.3, and 94.7%), specificity (72.7, 82.7, 89.0, and 91.7%), and FPR (27.3, 17.3, 11.0, and 8.4%) ( < 0.05). Higher breast density impaired recall rates (4.0% in P1, 9.0% in P2, 28.9% in P3, and 27.8% in P4), PPV (3.3, 2.3, 1.2, and 1.3%), specificity (96.1, 91.2, 71.4, and 72.5%), and FPR (3.9, 8.9, 28.6, and 27.6%) ( < 0.001). It also increased CDR (1.3, 2.1, 3.3, and 3.6) and ICR (0.2, 0.3, 0.6, and 1.6) ( < 0.05). Successive visits to the same institution improved recall rates (20.9% for one visit, 10.7% for two visits, 7.7% for more than three visits), PPV (1.6, 2.8, and 2.7%), specificity (79.4, 89.6, and 92.5%), and FPR (20.6, 10.4, and 7.5%) ( < 0.001). CONCLUSION: Young age and dense breasts negatively affected diagnostic performance in mammography screening, whereas successive visits to the same institution had a positive effect. Examinee education for successive visits to the same institution would improve the diagnostic performance.
[Mh] Termos MeSH primário: Neoplasias da Mama/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Densidade da Mama
Neoplasias da Mama/diagnóstico por imagem
Bases de Dados Factuais
Detecção Precoce de Câncer
Feminino
Seres Humanos
Mamografia
Meia-Idade
República da Coreia
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170704
[St] Status:MEDLINE
[do] DOI:10.3348/kjr.2017.18.4.624



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