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[PMID]:28449077
[Au] Autor:Jor'dan AJ; Poole VN; Iloputaife I; Milberg W; Manor B; Esterman M; Lipsitz LA
[Ad] Endereço:Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts.
[Ti] Título:Executive Network Activation is Linked to Walking Speed in Older Adults: Functional MRI and TCD Ultrasound Evidence From the MOBILIZE Boston Study.
[So] Source:J Gerontol A Biol Sci Med Sci;72(12):1669-1675, 2017 Nov 09.
[Is] ISSN:1758-535X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background: Changes in cerebral blood flow velocity (CBF) in response to a cognitive task (task-related ΔCBF) have been shown by Transcranial Doppler ultrasonography (TCD) to be reduced in slow walkers. However, it is unknown whether reduced task-related ΔCBF is associated with reduced neural activity in specific brain regions, as measured by blood-oxygen-level dependent (BOLD) functional magnetic resonance imaging (fMRI). Methods: We assessed the regional changes in neural activity associated with reduced middle cerebral artery (MCA) task-related ΔCBF to an executive task and slow walking speed in 67 community-dwelling older adults from the MOBILIZE Boston Study. Participants underwent walking assessments and TCD ultrasonography measures of MCA ΔCBF during the n-back task of executive function. A subset of participants (n = 27) completed the same task during fMRI. Individual BOLD activation maps for the n-back task were correlated with TCD measures and network-level averages were associated with TCD and preferred walking speed. Results: Participants with diminished task-related ΔCBF walked more slowly (ß = .39, p = .001). fMRI revealed significant associations between task-related ΔCBF and regional BOLD activation in several brain regions/networks supplied by the MCA. Of these regions and networks, those within the executive network were most strongly associated with walking speed (ß = .36, p = .01). Conclusions: Task-related ΔCBF during an executive function task is related to activation in several neural networks and impairment in the ability to recruit the executive network in particular is associated with slow walking speed in older adults.
[Mh] Termos MeSH primário: Circulação Cerebrovascular/fisiologia
Função Executiva/fisiologia
Imagem por Ressonância Magnética
Ultrassonografia Doppler Transcraniana
Velocidade de Caminhada/fisiologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Masculino
Rede Nervosa/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1093/gerona/glx063


  2 / 221 MEDLINE  
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[PMID]:29294185
[Au] Autor:Gomes V; Carretero MA; Kaliontzopoulou A
[Ad] Endereço:CIBIO Research Centre in Biodiversity and Genetic Resources, InBIO, Universidade do Porto, Campus de Vairão, Rua Padre Armando Quintas, N° 7, 4485-661, Vairao, Vila do Conde, Portugal. veronica.a.s.g@gmail.com.
[Ti] Título:Run for your life, but bite for your rights? How interactions between natural and sexual selection shape functional morphology across habitats.
[So] Source:Naturwissenschaften;105(1-2):9, 2018 Jan 02.
[Is] ISSN:1432-1904
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A central issue in evolutionary biology is how morphology, performance, and habitat use coevolve. If morphological variation is tightly associated with habitat use, then differences in morphology should affect fitness through their effect on performance within specific habitats. In this study, we investigate how evolutionary forces mold morphological traits and performance differently given the surrounding environment, at the intraspecific level. For this purpose, we selected populations of the lizard Podarcis bocagei from two different habitat types, agricultural walls and dunes, which we expected to reflect saxicolous vs ground-dwelling habits. In the laboratory, we recorded morphological traits as well as performance traits by measuring sprint speed, climbing capacity, maneuverability, and bite force. Our results revealed fast-evolving ecomorphological variation among populations of P. bocagei, where a direct association existed between head morphology and bite performance. However, we could not establish links between limb morphology and locomotor performance at the individual level. Lizards from walls were better climbers than those from dunes, suggesting a very fast evolutionary response. Interestingly, a significant interaction between habitat and sex was detected in climbing performance. In addition, lizards from dunes bit harder than those from walls, although sexual differentiation was definitely the main factor driving variation in head functional morphology. Taking into account all the results, we found a complex interaction between natural and sexual selection on whole-organism performance, which are, in some cases, reflected in morphological variation.
[Mh] Termos MeSH primário: Ecossistema
Lagartos/anatomia & histologia
Lagartos/fisiologia
Preferência de Acasalamento Animal
Seleção Genética
[Mh] Termos MeSH secundário: Animais
Força de Mordida
Lagartos/classificação
Velocidade de Caminhada
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE
[do] DOI:10.1007/s00114-017-1537-6


  3 / 221 MEDLINE  
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[PMID]:28453849
[Au] Autor:Erlandson KM; Wu K; Koletar SL; Kalayjian RC; Ellis RJ; Taiwo B; Palella FJ; Tassiopoulos K
[Ad] Endereço:Department of Medicine, University of Colorado-Anschutz Medical Campus, Aurora, USA.
[Ti] Título:Association Between Frailty and Components of the Frailty Phenotype With Modifiable Risk Factors and Antiretroviral Therapy.
[So] Source:J Infect Dis;215(6):933-937, 2017 03 15.
[Is] ISSN:1537-6613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The impact of antiretroviral therapy (ART) on frailty among human immunodeficiency virus (HIV)-infected adults has not been well described. HIV-infected participants aged ≥40 years with initial ART receipt through a randomized, controlled AIDS Clinical Trials Group trial completed a frailty assessment. Ordinal logistic regression models examined factors associated with frailty. Of 1016 participants, 6% were frail, and 38% were prefrail. Frailty was associated with lower education, older age, Medicare/Medicaid, initial efavirenz, smoking, obesity, and neurocognitive impairment; physical activity and alcohol use were protective. The associations with ART require further investigation, and associations between frailty and modifiable factors provide targets for future interventions.
[Mh] Termos MeSH primário: Terapia Antirretroviral de Alta Atividade
Idoso Fragilizado/estatística & dados numéricos
Infecções por HIV/tratamento farmacológico
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Fenótipo
Fatores de Risco
Estados Unidos
Velocidade de Caminhada
Perda de Peso
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jix063


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[PMID]:28464791
[Au] Autor:Duggan BM; Rae AM; Clements DN; Hocking PM
[Ad] Endereço:The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK. Brendan.Duggan@roslin.ed.ac.uk.
[Ti] Título:Higher heritabilities for gait components than for overall gait scores may improve mobility in ducks.
[So] Source:Genet Sel Evol;49(1):42, 2017 05 02.
[Is] ISSN:1297-9686
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Genetic progress in selection for greater body mass and meat yield in poultry has been associated with an increase in gait problems which are detrimental to productivity and welfare. The incidence of suboptimal gait in breeding flocks is controlled through the use of a visual gait score, which is a subjective assessment of walking ability of each bird. The subjective nature of the visual gait score has led to concerns over its effectiveness in reducing the incidence of suboptimal gait in poultry through breeding. The aims of this study were to assess the reliability of the current visual gait scoring system in ducks and to develop a more objective method to select for better gait. RESULTS: Experienced gait scorers assessed short video clips of walking ducks to estimate the reliability of the current visual gait scoring system. Kendall's coefficients of concordance between and within observers were estimated at 0.49 and 0.75, respectively. In order to develop a more objective scoring system, gait components were visually scored on more than 4000 pedigreed Pekin ducks and genetic parameters were estimated for these components. Gait components, which are a more objective measure, had heritabilities that were as good as, or better than, those of the overall visual gait score. CONCLUSIONS: Measurement of gait components is simpler and therefore more objective than the standard visual gait score. The recording of gait components can potentially be automated, which may increase accuracy further and may improve heritability estimates. Genetic correlations were generally low, which suggests that it is possible to use gait components to select for an overall improvement in both economic traits and gait as part of a balanced breeding programme.
[Mh] Termos MeSH primário: Patos/genética
Característica Quantitativa Herdável
Velocidade de Caminhada/genética
[Mh] Termos MeSH secundário: Animais
Fenótipo
Seleção Artificial
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180218
[Lr] Data última revisão:
180218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1186/s12711-017-0317-2


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[PMID]:28941716
[Au] Autor:Kim J; Garcia-Esquinas E; Navas-Acien A; Choi YH
[Ad] Endereço:Department of Preventive Medicine, Gachon University College of Medicine, Incheon, Republic of Korea. Electronic address: junghoonkim@gachon.ac.kr.
[Ti] Título:Blood and urine cadmium concentrations and walking speed in middle-aged and older U.S. adults.
[So] Source:Environ Pollut;232:97-104, 2018 Jan.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Reduced physical performance is an important feature of aging, and walking speed is a valid measure of physical performance and mobility in older adults. Previous epidemiological studies suggest that cadmium exposure, even at low environmental levels, may contribute to vascular, musculoskeletal, and cognitive dysfunction, which may all be associated with reductions in physical performance. To this end, we investigated the associations of blood and urine cadmium concentrations with walking speed in middle-aged and older adults in the U.S. general population. We studied U.S. adults from the National Health and Nutrition Examination Survey 1999 to 2002 who were ≥50 years of age, who had determinations of cadmium in blood or in urine, and who had measurements of the time taken to walk 20 feet. Walking speed (ft/sec) was computed as walked distance (20 ft) divided by measured time to walk (in seconds). The weighted geometric means of blood and urine cadmium were 0.49 [95% confidence interval (CI): 0.47, 0.52] µg/L and 0.37 (95% CI: 0.34, 0.42) ng/mL, respectively. After adjusting for sociodemographic, anthropometric, health-related behavioral, and clinical risk factors and inflammation markers, the highest (vs. lowest) quintile of blood cadmium was associated with a 0.18 (95% CI: 0.10, 0.25) ft/sec reduction in walking speed (p-Trend <0.001). No association was observed for urine cadmium levels with walking speed. Cadmium concentrations in blood, but not in urine, were associated with slower gait speed. Our findings add to the growing volume of evidence supporting cadmium's toxicity even at low levels of exposure.
[Mh] Termos MeSH primário: Cádmio/metabolismo
Cádmio/toxicidade
Exposição Ambiental/análise
Poluentes Ambientais/toxicidade
Velocidade de Caminhada/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adulto
Idoso
Cádmio/sangue
Cádmio/urina
Exposição Ambiental/estatística & dados numéricos
Poluentes Ambientais/sangue
Poluentes Ambientais/metabolismo
Poluentes Ambientais/urina
Feminino
Seres Humanos
Masculino
Meia-Idade
Inquéritos Nutricionais
Fatores de Risco
Estados Unidos
Caminhada
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Environmental Pollutants); 00BH33GNGH (Cadmium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170925
[St] Status:MEDLINE


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[PMID]:28454071
[Au] Autor:Dingwell JB; Salinas MM; Cusumano JP
[Ad] Endereço:Department of Kinesiology & Health Education, University of Texas, Austin, TX 78712, United States. Electronic address: jdingwell@austin.utexas.edu.
[Ti] Título:Increased gait variability may not imply impaired stride-to-stride control of walking in healthy older adults: Winner: 2013 Gait and Clinical Movement Analysis Society Best Paper Award.
[So] Source:Gait Posture;55:131-137, 2017 Jun.
[Is] ISSN:1879-2219
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Older adults exhibit increased gait variability that is associated with fall history and predicts future falls. It is not known to what extent this increased variability results from increased physiological noise versus a decreased ability to regulate walking movements. To "walk", a person must move a finite distance in finite time, making stride length (L ) and time (T ) the fundamental stride variables to define forward walking. Multiple age-related physiological changes increase neuromotor noise, increasing gait variability. If older adults also alter how they regulate their stride variables, this could further exacerbate that variability. We previously developed a Goal Equivalent Manifold (GEM) computational framework specifically to separate these causes of variability. Here, we apply this framework to identify how both young and high-functioning healthy older adults regulate stepping from each stride to the next. Healthy older adults exhibited increased gait variability, independent of walking speed. However, despite this, these healthy older adults also concurrently exhibited no differences (all p>0.50) from young adults either in how their stride variability was distributed relative to the GEM or in how they regulated, from stride to stride, either their basic stepping variables or deviations relative to the GEM. Using a validated computational model, we found these experimental findings were consistent with increased gait variability arising solely from increased neuromotor noise, and not from changes in stride-to-stride control. Thus, age-related increased gait variability likely precedes impaired stepping control. This suggests these changes may in turn precede increased fall risk.
[Mh] Termos MeSH primário: Envelhecimento/fisiologia
Marcha/fisiologia
Caminhada/fisiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Simulação por Computador
Feminino
Seres Humanos
Masculino
Velocidade de Caminhada/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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[PMID]:28448899
[Au] Autor:Chia K; Sangeux M
[Ad] Endereço:Hugh Williamson Gait Analysis Laboratory, Royal Children's Hospital, Melbourne, Australia; Murdoch Childrens Research Institute, Melbourne, Australia. Electronic address: kohleth.chia@mcri.edu.au.
[Ti] Título:Undesirable properties of the dimensionless normalisation for spatio-temporal variables.
[So] Source:Gait Posture;55:157-161, 2017 Jun.
[Is] ISSN:1879-2219
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We used theory and empirical data to demonstrate three undesirable properties of the dimensionless normalisation technique for gait spatio-temporal parameters. Firstly, it may not fully remove the correlation between leg length and spatio-temporal parameters. Secondly, it induces spurious correlation among spatio-temporal parameters, which might obscure their true correlation structure. Thirdly, it induces spurious correlation with external covariates, which complicates further statistical modelling. Therefore, depending on the objectives, we propose alternatives. If the objective is to compare datasets but remove the confounding effect of leg length, residualisation may be an alternative, although the generalisability of the residualisation is less well established than dimensionless normalisation. If the objective is to build a regression model, the raw spatio-temporal parameters could be used with leg length, or a function of leg length, as an explicit regressor to avoid spurious correlation. If correlation is the objective, partial correlation can be used instead.
[Mh] Termos MeSH primário: Marcha/fisiologia
Modelos Estatísticos
[Mh] Termos MeSH secundário: Criança
Feminino
Seres Humanos
Extremidade Inferior/anatomia & histologia
Masculino
Velocidade de Caminhada/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE


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[PMID]:28465220
[Au] Autor:Sanjak M; Langford V; Holsten S; Rozario N; Patterson CGM; Bravver E; Bockenek WL; Brooks BR
[Ad] Endereço:Neuroscience Institute - Neurology, Carolinas Neuromuscular/ALS-MDA Center, Carolinas Healthcare System, Charlotte, NC; Department of Kinesiology, College of Health and Human Service, University of North Carolina, Charlotte, NC. Electronic address: Mohammed.Sanjak@carolinashealthcare.org.
[Ti] Título:Six-Minute Walk Test as a Measure of Walking Capacity in Ambulatory Individuals With Amyotrophic Lateral Sclerosis.
[So] Source:Arch Phys Med Rehabil;98(11):2301-2307, 2017 11.
[Is] ISSN:1532-821X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To determine the validity of the 6-minute walk test (6MWT) as an outcome measure to evaluate walking capacity in ambulatory patients with amyotrophic lateral sclerosis (ALS). DESIGN: Observational study. SETTING: Multidisciplinary ALS clinic at an academic medical center. PARTICIPANTS: Patients with ALS (N=186) who ambulate without (stage I) or with (stage II) an assistive device. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURE: Walking distance obtained from the 6MWT. RESULTS: Participants performed the 6MWT, 25-foot walk test (25FWT), Timed Up and Go (TUG) test, lower extremity maximum voluntary isometric contraction (MVIC), ALS Functional Rating Scale-Revised (ALSFRS-R), and forced vital capacity (FVC). Walking capacity was reduced to 66% predicted of healthy subjects (75.2%±22% in stage I; 42.6%±22% in stage II). The 6MWT correlated with all other outcome measures in ambulatory patients with ALS (25FWT: r=-.74, P≤.0001; TUG test: r=-.80, P≤.0001; MVIC: r=.64, P≤.0001; percent predicted FVC: r=.25, P≤.0007; ALSFRS-R: r=.52, P≤.0001; ALSFRS-R gross motor subscore: r=.71, P≤.0001). When ambulatory patients with ALS were stratified by stage of ambulation, the 6MWT was associated with all other outcome measures in stage I (25FWT: r=-.56, P≤.0001; TUG test: r=-.66, P≤.0001; MVIC: r=.51, P≤.0001; percent predicted FVC: r=.40, P≤.02; ALSFRS-R: r=.52, P≤.0001; ALSFRS-R gross motor subscore: r=.61, P≤.0001). In stage II, the 6MWT correlated with the 25FWT (r=-.83, P≤.0001), TUG test (r=-.77, P≤.0001), MVIC (r=.47, P≤.0001), and ALSFRS gross motor subscore (r=.61, P≤.0001), but not with percent predicted FVC (r=.09, P≤.513) or ALSFRS-R (r=.21, P≤.141). CONCLUSIONS: The 6MWT is a valid measure of walking capacity of ambulatory patients with ALS that is associated with measures of lower extremity muscle strength and function in both stages of ambulation. The discordance between the 6MWT with the ALSFRS-R and percent predicted FVC in stage II ambulatory patients with ALS indicates that the 6MWT is an independent measure of ambulatory function in both stages of ambulation. The 6MWT may provide a quantitative, simple, and inexpensive outcome measure of walking capacity for early stage clinical trials in ambulatory patients with ALS.
[Mh] Termos MeSH primário: Esclerose Amiotrófica Lateral/reabilitação
Modalidades de Fisioterapia/normas
Capacidade Vital/fisiologia
Caminhada/fisiologia
[Mh] Termos MeSH secundário: Centros Médicos Acadêmicos
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Força Muscular/fisiologia
Equilíbrio Postural
Reprodutibilidade dos Testes
Velocidade de Caminhada
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


  9 / 221 MEDLINE  
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[PMID]:29205208
[Au] Autor:Guzik A; Druzbicki M; Przysada G; Kwolek A; Brzozowska-Magon A; Sobolewski M
[Ad] Endereço:Institute of Physiotherapy, University of Rzeszów, Rzeszów, Poland.
[Ti] Título:Relationships between walking velocity and distance and the symmetry of temporospatial parameters in chronic post-stroke subjects.
[So] Source:Acta Bioeng Biomech;19(3):147-154, 2017.
[Is] ISSN:1509-409X
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Subjects with post-stroke hemiparesis frequently present with asymmetric gait patterns. Symmetry, reflecting similarities in temporospatial, kinematic parameters, is an important measure of gait assessment. The study was designed to examine the relationships between asymmetry of temporal, spatial and kinematic gait parameters and walking velocity and distance. METHODS: Temporospatial and kinematic gait parameters were examined in a group of 50 chronic post-stroke subjects and in a group of 25 healthy controls. Symmetry ratio was calculated for all the parameters. Gait velocity was measured during 10-metre test, the walking distance during 2-Minute Walk Test, and balance during Up and Go Test. RESULTS: The relationship between stance phase duration symmetry and gait speed was at a moderate level (r = -0.43, p = 0.0173). There was a moderate relationship between swing phase symmetry and walking velocity and distance. The findings did not show a significant correlation between step length symmetry versus gait speed and distance. CONCLUSIONS: There is a mild relationship between self-selected gait velocity and walking distance versus temporal parameters symmetry. The findings do not confirm a relationship between self-selected gait velocity and walking distance versus spatial and kinematic parameters as well as balance. Likewise, no evidence confirms that asymmetry of temporal, spatial, kinematic gait parameters changes with the age of post-stroke subjects or is related to the length of time from stroke onset. Given the above, gait symmetry may be recognized as an important indicator of the level of gait control in post-stroke patients because it enables unique gait assessment, independent from other parameters.
[Mh] Termos MeSH primário: Lateralidade Funcional
Transtornos Neurológicos da Marcha/fisiopatologia
Paresia/fisiopatologia
Esforço Físico
Acidente Vascular Cerebral/fisiopatologia
Velocidade de Caminhada
[Mh] Termos MeSH secundário: Doença Crônica
Simulação por Computador
Feminino
Transtornos Neurológicos da Marcha/etiologia
Seres Humanos
Perna (Membro)/fisiopatologia
Masculino
Meia-Idade
Modelos Biológicos
Paresia/etiologia
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Análise Espaço-Temporal
Acidente Vascular Cerebral/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE


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[PMID]:29244874
[Au] Autor:Grobelny A; Behrens JR; Mertens S; Otte K; Mansow-Model S; Krüger T; Gusho E; Bellmann-Strobl J; Paul F; Brandt AU; Schmitz-Hübsch T
[Ad] Endereço:Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, NeuroCure Cluster of Excellence, NeuroCure Clinical Research Center, Berlin, Germany.
[Ti] Título:Maximum walking speed in multiple sclerosis assessed with visual perceptive computing.
[So] Source:PLoS One;12(12):e0189281, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Gait is often impaired in people with multiple sclerosis (PwMS), but detailed assessment of gait impairment in research and care remains challenging. In a previous pilot study we reported the feasibility of visual perceptive computing (VPC) for gait assessment in PwMS using the Short Maximum Speed Walk (SMSW), which assesses gait on recording distances confined to less than 4 meters. OBJECTIVE: To investigate the equivalence of SMSW to rater-based timed 25ft. walk (T25FW) in a large cohort of PwMS, and to investigate the association of SMSW-derived gait parameters with clinical disability, as well as subjective and objective gait impairment, in order to validate the SMSW as a quick and objective measure of clinical relevance possibly superior to T25FW. METHODS: 95 PwMS and 60 healthy controls (HC) performed the SMSW using a VPC system with Microsoft Kinect. All participants received two immediate retests to establish test-retest-reliability. Both PwMS and HC performed the T25FW. PwMS were rated according to the Expanded Disability Status Scale (EDSS) and answered the 12-item Multiple Sclerosis Walking Scale (MSWS-12) as a measure of self-perceived walking impairment. RESULTS: PwMS showed reduced average speed (p<0.001) and higher mediolateral deviation (p = 0.002) during SMSW than HC. Average speed was the most reliable SMSW parameter in PwMS and HC (intra-class correlation coefficient (ICC) in PwMS = 0.985, and in HC = 0.977). Average speed declined with age in PwMS and HC (r in PwMS = -0.648, and in HC = -0.452, both p<0.001). Correlation of SMSW average speed and T25FW speed was high in both groups (r in PwMS = 0.783, and in HC = 0.747, both p<0.001) and mean difference (0.0013 m/s) between methods was below smallest detectable change. Average speed correlated well with both clinical disability based on EDSS (r = -0.586, p<0.001) and self-perceived walking impairment based on MSWS-12 (r = -0.546, p<0.001). CONCLUSION: VPC-assessed walking parameters during SMSW can reliably detect gait disturbance in PwMS over very short distance. Specifically, maximum gait speed can be obtained with high accuracy in this simple test set-up. Cross-sectional associations with disability and self-perceived walking impairment support clinical relevance. Given its objectivity in a simple test set-up, SMSW is superior to T25FW.
[Mh] Termos MeSH primário: Transtornos Neurológicos da Marcha/diagnóstico por imagem
Esclerose Múltipla/diagnóstico por imagem
Velocidade de Caminhada
[Mh] Termos MeSH secundário: Adulto
Idoso
Estudos de Casos e Controles
Estudos Transversais
Avaliação da Deficiência
Feminino
Transtornos Neurológicos da Marcha/fisiopatologia
Seres Humanos
Interpretação de Imagem Assistida por Computador
Masculino
Meia-Idade
Esclerose Múltipla/fisiopatologia
Reprodutibilidade dos Testes
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189281



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