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[PMID]: 29305450 [Au] Autor: Kono K; Tomita T; Futai K; Yamazaki T; Tanaka S; Yoshikawa H; Sugamoto K [Ad] Endereço: Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan and Department of Orthopaedic Biomaterial Science, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan. [Ti] Título: three-dimensional kinematics of normal knees during different high-flexion activities. [So] Source: Bone Joint J;100-B(1):50-55, 2018 Jan. [Is] ISSN: 2049-4408 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: AIMS: In Asia and the Middle-East, people often flex their knees deeply in order to perform activities of daily living. The purpose of this study was to investigate the 3D kinematics of normal knees during high-flexion activities. Our hypothesis was that the femorotibial rotation, varus-valgus angle, translations, and kinematic pathway of normal knees during high-flexion activities, varied according to activity. MATERIALS AND METHODS: We investigated the kinematics of eight normal knees in four male volunteers (mean age 41.8 years; 37 to 53) using 2D and 3D registration technique, and modelled the knees with a computer aided design program. Each subject squatted, kneeled, and sat cross-legged. We evaluated the femoral rotation and varus-valgus angle relative to the tibia and anteroposterior translation of the medial and lateral side, using the transepicodylar axis as our femoral reference relative to the perpendicular projection on to the tibial plateau. This method evaluates the femur medially from what has elsewhere been described as the extension facet centre, and differs from the method classically applied. RESULTS: During squatting and kneeling, the knees displayed femoral external rotation. When sitting cross-legged, femurs displayed internal rotation from 10° to 100°. From 100°, femoral external rotation was observed. No significant difference in varus-valgus angle was seen between squatting and kneeling, whereas a varus position was observed from 140° when sitting cross-legged. The measure kinematic pathway using our methodology found during squatting a medial pivoting pattern from 0° to 40° and bicondylar rollback from 40° to 150°. During kneeling, a medial pivot pattern was evident. When sitting cross-legged, a lateral pivot pattern was seen from 0° to 100°, and a medial pivot pattern beyond 100°. CONCLUSION: The kinematics of normal knees during high flexion are variable according to activity. Nevertheless, our study was limited to a small number of male patients using a different technique to report the kinematics than previous publications. Accordingly, caution should be observed in generalizing our findings. Cite this article: 2018;100-B:50-5. [Mh] Termos MeSH primário: Fenômenos Biomecânicos/fisiologia Articulação do Joelho/fisiologia [Mh] Termos MeSH secundário: Atividades Cotidianas Adulto Simulação por Computador Projeto Auxiliado por Computador Fluoroscopia Seres Humanos Imagem Tridimensional/métodos Articulação do Joelho/diagnóstico por imagem Masculino Meia-Idade Modelos Anatômicos Amplitude de Movimento Articular/fisiologia Rotação [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180311 [Lr] Data última revisão: 180311 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180107 [St] Status: MEDLINE [do] DOI: 10.1302/0301-620X.100B1.BJJ-2017-0553.R2

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[PMID]: 29390376 [Au] Autor: Han SB; Kyung HS; Seo IW; Shin YS [Ad] Endereço: Department of Orthopedic Surgery, Korea University Anam Hospital, Korea University College of Medicine, Seoul. [Ti] Título: Better clinical outcomes after unicompartmental knee arthroplasty when comparing with high tibial osteotomy. [So] Source: Medicine (Baltimore);96(50):e9268, 2017 Dec. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Both high tibial osteotomy (HTO) and unicompartmental knee arthroplasty (UKA) are well-established treatments for medial knee osteoarthritis (OA). However, it is unclear whether HTO or UKA leads to better clinical outcomes and lower complication rates. This meta-analysis compared the clinical outcomes and complications of HTO and UKA in patients with medial knee OA. METHODS: All studies comparing the functional outcome, postoperative pain, revision rate to total knee arthroplasty (TKA), postoperative complications, postoperative velocity, and postoperative range of motion (ROM) as assessed with various measurement tools in patients with medial knee OA treated with HTO or UKA were included. RESULTS: Sixteen studies were included in the meta-analysis. The proportion of patients who underwent revision to TKA (OR 1.56, 95% CI: 0.61-3.98; P = .35) did not differ significantly between HTO and UKA. In contrast, functional outcome (OR 0.47, 95% CI: 0.24 to 0.95; P = .04), postoperative pain (OR 0.28, 95% CI: 0.12 to 0.62; P = .002), postoperative complications (OR 2.48, 95% CI: 1.26 to 4.90; P = .009), postoperative velocity (95% CI: -0.11 to -0.00; P = .03), and postoperative ROM (95% CI: 2.02 to 15.23; P = .01) were significantly different between the 2 groups. CONCLUSIONS: There were no significant differences in the revision rate to TKA between HTO and UKA. However, results from subgroup analyses suggested that opening-wedge HTO resulted in a lower revision rate to TKA than did UKA, whereas closing-wedge HTO resulted in a higher revision rate to TKA than did UKA. In addition, UKA resulted in significantly better functional outcomes and postoperative velocity, along with less postoperative pain, fewer postoperative complications, and lower postoperative ROM. Based on the findings of current meta-analysis, UKA appears to be as efficacious and safe as HTO in the treatment of medial knee OA. [Mh] Termos MeSH primário: Artroplastia do Joelho/métodos Osteoartrite do Joelho/cirurgia Osteotomia/métodos Tíbia/cirurgia [Mh] Termos MeSH secundário: Seres Humanos Amplitude de Movimento Articular Reoperação [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE; META-ANALYSIS [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180301 [Lr] Data última revisão: 180301 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180203 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000009268

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[PMID]: 29304163 [Au] Autor: Takeuchi Y [Ad] Endereço: Department of Rehabilitation Science, Faculty of Health Care Science, Chiba Prefectural University of Health Sciences, Chuoku, Chiba, Japan. [Ti] Título: A successful backward step correlates with hip flexion moment of supporting limb in elderly people. [So] Source: PLoS One;13(1):e0190797, 2018. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: PURPOSE: The objective of this study was to determine the positional relationship between the center of mass (COM) and the center of pressure (COP) at the time of step landing, and to examine their relationship with the joint moments exerted by the supporting limb, with regard to factors of the successful backward step response. METHODS: The study population comprised 8 community-dwelling elderly people that were observed to take successive multi steps after the landing of a backward stepping. Using a motion capture system and force plate, we measured the COM, COP and COM-COP deviation distance on landing during backward stepping. In addition, we measured the moment of the supporting limb joint during backward stepping. The multi-step data were compared with data from instances when only one step was taken (single-step). Variables that differed significantly between the single- and multi-step data were used as objective variables and the joint moments of the supporting limb were used as explanatory variables in single regression analyses. RESULTS: The COM-COP deviation in the anteroposterior was significantly larger in the single-step. A regression analysis with COM-COP deviation as the objective variable obtained a significant regression equation in the hip flexion moment (R2 = 0.74). CONCLUSIONS: The hip flexion moment of supporting limb was shown to be a significant explanatory variable in both the PS and SS phases for the relationship with COM-COP distance. This study found that to create an appropriate backward step response after an external disturbance (i.e. the ability to stop after 1 step), posterior braking of the COM by a hip flexion moment are important during the single-limbed standing phase. [Mh] Termos MeSH primário: Articulação do Quadril/fisiologia Amplitude de Movimento Articular Caminhada [Mh] Termos MeSH secundário: Idoso Feminino Seres Humanos Masculino Meia-Idade [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180223 [Lr] Data última revisão: 180223 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180106 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0190797

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[PMID]: 29390497 [Au] Autor: Lee JH [Ti] Título: The short-term effectiveness of balance taping on acute nonspecific low-back pain: A case report. [So] Source: Medicine (Baltimore);96(51):e9304, 2017 Dec. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: RATIONALE: Low back pain has a significant socioeconomic impact. Repetitive lifting, with combined twisting and flexion motions of the lumbar spine, increases the risk for low-back pain and injury to the supporting tissues. PATIENT CONCERNS: A 60-year-old male who presented with acute low-back pain, with a pain intensity of 6/10 on the visual analog scale (VAS) and an Oswestry disability index (ODI) score of 70%. The range of motion (ROM) of the lumbar spine on initial examination, relative to the normal peak ROM, was as follows: extension, 12°/30°; flexion, 15°/80°; left rotation, 15°/45°; and right rotation, 25°/45°. DIAGNOSES: He was diagnosed as acute nonspecific low-back pain sustained with repetitive lifting, combining motions of flexion and twisting. INTERVENTIONS: The balance taping was applied for 16 h/day, on average, for 3 consecutive days was used as the primary treatment to manage the patient's low-back pain. OUTCOMES: The application of balance taping increased the range of motion of the lumbar spine as follows: flexion, from 15° to 77°; extension, from 12° to 27°; right rotation, from 25° to 45°; and left rotation, from 15° to 45°. The ODI score decreased from 70% to 0%, and the VAS score from 6/10 to 0. LESSONS: We propose that balance taping using kinesiology tape could serve as a complementary approach to other treatments for the treatment of acute nonspecific low-back pain. [Mh] Termos MeSH primário: Fita Atlética Dor Lombar/reabilitação [Mh] Termos MeSH secundário: Avaliação da Deficiência Seres Humanos Dor Lombar/fisiopatologia Masculino Meia-Idade Amplitude de Movimento Articular/fisiologia Escala Visual Analógica [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180220 [Lr] Data última revisão: 180220 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180203 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000009304

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[PMID]: 29384947 [Au] Autor: Park EH; Lee KB [Ad] Endereço: Department of Radiology. [Ti] Título: Usefulness of black boundary artifact on opposed-phase imaging from turbo spin-echo two-point mDixon MRI for delineation of an arthroscopically confirmed small fracture of the lateral talar dome: A case report. [So] Source: Medicine (Baltimore);96(52):e9497, 2017 Dec. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: RATIONALE: A nondisplaced chip fracture can be missed on MRI. Opposed-phase imaging from mDixon MRI produces an interesting artifact called black boundary artifact. This artifact can provide better contrast at the fracture line resulting in better depiction of a small chip fracture on MRI. PATIENT CONCERNS: We present a case of small nondisplaced chip fracture at the lateral talar dome that was well delineated only with the aid of a black boundary artifact after using T2-weighted opposed-phase imaging from turbo spin-echo two-point modified Dixon ankle MRI. In other sequences, the lesion demonstrated a focal full thickness cartilage defect, subtle cortical irregularity, or subcortical bone marrow edema but the full delineation of the fracture line was not possible. DIAGNOSES: Opposed-phase imaging from mDixon MRI aided in the diagnosis of lateral talar dome osteochondral fracture (osteochondral lesion), which was confirmed arthroscopically. INTERVENTIONS: The osteochondral fragment was removed by arthroscopy. OUTCOMES: The patient did well with recovery of full range of motion after 2 months. LESSONS: We have identified a black boundary artifact using opposed-phase imaging from mDixon MRI that can aid in detection of small fracture, which can be missed by conventional MRI, by providing a dark linear signal at the fracture line. [Mh] Termos MeSH primário: Fraturas Ósseas/diagnóstico por imagem Interpretação de Imagem Assistida por Computador/métodos Imagem por Ressonância Magnética/métodos Tálus/diagnóstico por imagem Tálus/lesões [Mh] Termos MeSH secundário: Artroscopia/métodos Fraturas Ósseas/cirurgia Seres Humanos Masculino Meia-Idade Amplitude de Movimento Articular Tálus/cirurgia [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180220 [Lr] Data última revisão: 180220 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180201 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000009497

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[PMID]: 29381917 [Au] Autor: Zhou L; Fan J; Cheng L; Jiang T; Yun B; Tang G; Yin J; Fang J; Yin G [Ad] Endereço: Department of Orthopedics, the First Affiliated Hospital of Nanjing Medical University. [Ti] Título: Changes of cervical sagittal alignments during motions in patients with cervical kyphosis. [So] Source: Medicine (Baltimore);96(47):e8410, 2017 Nov. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Changes of cervical sagittal alignment during motion in cervical kyphosis patients have never been published before. This study was to investigate the changes and provide a better reference for orthopedic treatment.Randomized double-blind repeat trial was carried out on 60 patients with cervical kyphosis. On standard position, hyper flexion, and hyper extension sagittal radiographs, the following measurements were made: the C2-7 vertebral body spatial alignment angle (∠A), C2-7 vertebral lower terminal lamina tilt angle (∠B), C2/3 to C6/7 segmental intervertebral space angle (∠C), the distance from the posterior edge of odontoid to C7 vertebral body (D value), and the difference of angle A, B, and C between cervical flexion and extension movement. Another 60 healthy volunteers were enrolled, of whom the cervical curve apex was determined using Borden's method to compare change and distribution characteristics to patients with cervical kyphosis and C value.In standard lateral position, ∠A was positive and increased from C2 to C7. In hyper extension position, ∠A decreased with reducing amplitude from C2 to C7 compared with the standard position, whereas in hyper flexion position, the average value of ∠A increased with decreasing amplitude from C2 to C7. ∠B followed similar change regularities as ∠A with a larger mean value. In cervical flexion and extension movement, ∠A change of upper vertebral body (∠D) was almost equal to ∠A change of lower vertebral body and ∠C change between the adjacent 2 vertebral bodies (∠E). The curve apex distribution was almost between C4 and C5 in cervical kyphosis patients. A significant difference was observed between cervical kyphosis patients and normal people in C value and D value.The correction of the cervical kyphosis can be carried out from the apex of the cervical spine that provides a solid theoretical foundation for the correction of the cervical kyphosis. [Mh] Termos MeSH primário: Vértebras Cervicais Cabeça/fisiologia Cifose/fisiopatologia Amplitude de Movimento Articular/fisiologia [Mh] Termos MeSH secundário: Adolescente Adulto Idoso Fenômenos Biomecânicos Método Duplo-Cego Feminino Seres Humanos Masculino Meia-Idade Movimento (Física) Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180220 [Lr] Data última revisão: 180220 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180201 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000008410

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[PMID]: 28095747 [Au] Autor: Casanova N; Reis JF; Vaz JR; Machado R; Mendes B; Button DC; Pezarat-Correia P; Freitas SR [Ad] Endereço: a CIPER, Faculdade de Motricidade Humana , Universidade de Lisboa, Estrada da Costa , Cruz Quebrada , Dafundo , Portugal. [Ti] Título: Effects of roller massager on muscle recovery after exercise-induced muscle damage. [So] Source: J Sports Sci;36(1):56-63, 2018 Jan. [Is] ISSN: 1466-447X [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Two experiments (n = 10) were conducted to determine the effects of roller massager (RM) on ankle plantar flexor muscle recovery after exercise-induced muscle damage (EIMD). Experiment 1 examined both functional [i.e., ankle plantar flexion maximal isometric contraction and submaximal (30%) sustained force; ankle dorsiflexion maximal range of motion and resistance to stretch; and medial gastrocnemius pain pressure threshold] and morphological [cross-sectional area, thickness, fascicle length, and fascicle angle] variables, before and immediately, 1, 24, 48, and 72 h after an EIMD stimulus. Experiment 2 examined medial gastrocnemius deoxyhaemoglobin concentration kinetics before and 48 h after EIMD. Participants performed both experiments twice: with (RM) and without (no-roller massager; NRM) the application of a RM (6 × 45 s; 20-s rest between sets). RM intervention did not alter the functional impairment after EIMD, as well as the medial gastrocnemius morphology and oxygenation kinetics (P > 0.05). Although, an acute increase of ipsilateral (RM = + 19%, NRM = -5%, P = 0.032) and a strong tendency for contralateral (P = 0.095) medial gastrocnemius pain pressure threshold were observed. The present results suggest that a RM has no effect on plantar flexors performance, morphology, and oxygenation recovery after EIMD, except for muscle pain pressure threshold (i.e., a soreness). [Mh] Termos MeSH primário: Massagem/métodos Músculo Esquelético/lesões Mialgia/terapia [Mh] Termos MeSH secundário: Traumatismos do Tornozelo/patologia Traumatismos do Tornozelo/fisiopatologia Traumatismos do Tornozelo/terapia Articulação do Tornozelo/fisiopatologia Feminino Seres Humanos Contração Isométrica/fisiologia Masculino Massagem/instrumentação Músculo Esquelético/diagnóstico por imagem Músculo Esquelético/patologia Músculo Esquelético/fisiopatologia Mialgia/patologia Mialgia/fisiopatologia Consumo de Oxigênio Limiar da Dor/fisiologia Amplitude de Movimento Articular/fisiologia Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180220 [Lr] Data última revisão: 180220 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170119 [St] Status: MEDLINE [do] DOI: 10.1080/02640414.2017.1280609

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[PMID]: 29390517 [Au] Autor: Tong MJ; Xiang GH; He ZL; Xu HZ; Tian NF [Ad] Endereço: Department of Spine Surgery, Zhejiang Spine Research Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. [Ti] Título: Cervical digit in a child: A case report. [So] Source: Medicine (Baltimore);96(51):e9348, 2017 Dec. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: A "digit-like" bone is a rare developmental anomaly that is usually seen in the pelvic or thoracic regions. Such an anomaly in the cervical spine is extremely rare and few cases have been reported. We present a patient with an anomalous bone posterior to a cervical vertebra. The patient was admitted to our hospital with a gradually growing hard neck mass and esthetic complaints. Physical examination, radiographs, reconstructed computed tomography, and magnetic resonance imaging revealed a digit-like bone posterior to the cervical spine. The patient was diagnosed with a "cervical digit." Through a posterior midline approach, the anomalous bone was excised because of its gradually increasing size and esthetic complaints. RESULTS: Intraoperatively, the bony mass was found to have a pseudoarticulation with the spinous process of C5 (the fifth cervical vertebra). The specimen consisted of normal bone and cartilage. The child returned to a normal life postoperatively with no symptoms. There was no recurrence at the 2-year follow-up. CONCLUSION: A congenital cervical digit is a rare deformity. A detailed clinical workup and advanced imaging examinations are useful for diagnosing such conditions. Esthetic complaints contribute to surgical indications. This is the first cervical digit managed with surgical excision of the anomalous bone and had a favorable outcome. [Mh] Termos MeSH primário: Vértebras Cervicais/anormalidades Imagem Tridimensional Anormalidades Musculoesqueléticas/diagnóstico por imagem Osteotomia/métodos Amplitude de Movimento Articular/fisiologia [Mh] Termos MeSH secundário: Vértebras Cervicais/diagnóstico por imagem Criança Seguimentos Seres Humanos Masculino Anormalidades Musculoesqueléticas/cirurgia Doenças Raras Medição de Risco Tomografia Computadorizada por Raios X/métodos Resultado do Tratamento [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180219 [Lr] Data última revisão: 180219 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180203 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000009348

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[PMID]: 29437062 [Au] Autor: Gaspar MP; Pham PP; Pankiw CD; Jacoby SM; Shin EK; Osterman AL; Kane PM [Ad] Endereço: Philadelphia Hand to Shoulder Center, Thomas Jefferson University, 834 Chestnut Street, The Franklin Building, Suite G114, Philadelphia, PA 19107, USA and Darden School of Business, University of Virginia, 100 Darden Boulevard, Charlottesville, Virginia 22903, USA. [Ti] Título: Mid-term outcomes of routine proximal row carpectomy compared with proximal row carpectomy with dorsal capsular interposition arthroplasty for the treatment of late-stage arthropathy of the wrist. [So] Source: Bone Joint J;100-B(2):197-204, 2018 Feb. [Is] ISSN: 2049-4408 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: AIMS: The aims of this study were to compare the mid-term outcomes of patients with late-stage arthritis of the wrist treated with proximal row carpectomy (PRC) and dorsal capsular interposition (DCI) arthroplasty with a matched cohort treated with routine PRC alone. PATIENTS AND METHODS: A total of 25 arthritic wrists (24 patients) with pre-existing degenerative changes of the proximal capitate and/or the lunate fossa of the radius were treated with PRC + DCI over a ten-year period. This group of patients were matched 1:2 with a group of 50 wrists (48 patients) without degenerative changes in the capitate or lunate fossa that were treated with a routine PRC alone during the same period. The mean age of the patients at the time of surgery was 56.8 years (25 to 81), and the demographics and baseline range of movement of the wrist, grip strength, Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH) score, and Patient-Rated Wrist Evaluation (PRWE) score were similar in both groups. RESULTS: At a mean follow-up of 5.9 years (1.8 to 11.8), significant improvements in mean grip strength, the flexion-extension arc of movement of the wrist, QuickDASH, and PRWE scores were seen in both groups. There was no diifference between the groups for any of the outcomes. One patient in the PRC + DCI group required additional surgery for a deep infection, while two in the PRC group had complications (one wound dehiscence requiring revision closure, one transient radial sensory neuritis). One patient in each group required total arthrodesis of the wrist for progressive degenerative radiocarpal changes. A total of 70 patients (93%) were satisfied with the outcomes. CONCLUSION: PRC with DCI is an effective form of treatment for late-stage arthritis of the wrist involving the capitolunate joint, with mid-term outcomes that are similar to those in patients without degenerative changes affecting the capitate or lunate fossa who are treated with a routine PRC alone. Cite this article: 2018;100-B:197-204. [Mh] Termos MeSH primário: Artroplastia/métodos Ossos do Carpo/cirurgia Osteoartrite/cirurgia Articulação do Punho/cirurgia [Mh] Termos MeSH secundário: Adulto Idoso Idoso de 80 Anos ou mais Avaliação da Deficiência Feminino Seguimentos Força da Mão Seres Humanos Masculino Meia-Idade Satisfação do Paciente Amplitude de Movimento Articular Retalhos Cirúrgicos Resultado do Tratamento [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180216 [Lr] Data última revisão: 180216 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180214 [St] Status: MEDLINE [do] DOI: 10.1302/0301-620X.100B2.BJJ-2017-0816.R2

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[PMID]: 29316908 [Au] Autor: Haroyan A; Mukuchyan V; Mkrtchyan N; Minasyan N; Gasparyan S; Sargsyan A; Narimanyan M; Hovhannisyan A [Ad] Endereço: "Erebuni" Medical Center, 14 Titogradian Street, 0087, Yerevan, Armenia. rheumo_arm@yahoo.com. [Ti] Título: Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study. [So] Source: BMC Complement Altern Med;18(1):7, 2018 Jan 09. [Is] ISSN: 1472-6882 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: The aim of this clinical trial was to assess the efficacy and safety of curcuminoid complex extract from turmeric rhizome with turmeric volatile oil (CuraMed®) and its combination with boswellic acid extract from Indian frankincense root (Curamin®) vs placebo for the treatment of 40- to 70-year-old patients with osteoarthritis (OA). METHODS: The effects of CuraMed® 500-mg capsules (333 mg curcuminoids) and Curamin® 500-mg capsules (350 mg curcuminoids and 150 mg boswellic acid) taken orally three times a day for 12 weeks in 201 patients was investigated in a three-arm, parallel-group, randomized, double-blinded, placebo-controlled trial. Primary outcome efficacy measures included OA physical function performance-based tests, the WOMAC recommended index of joint pain, morning stiffness, limitations of physical function, and the patients' global assessment of disease severity. RESULTS: Favorable effects of both preparations compared to placebo were observed after only 3 months of continuous treatment. A significant effect of Curamin® compared to placebo was observed both in physical performance tests and the WOMAC joint pain index, while superior efficacy of CuraMed vs placebo was observed only in physical performance tests. The effect size compared to placebo was comparable for both treatment groups but was superior in the Curamin® group. The treatments were well tolerated. CONCLUSIONS: Twelve-week use of curcumin complex or its combination with boswellic acid reduces pain-related symptoms in patients with OA. Curcumin in combination with boswellic acid is more effective. Combining Curcuma longa and Boswellia serrata extracts in Curamin® increases the efficacy of OA treatment presumably due to synergistic effects of curcumin and boswellic acid. TRIAL REGISTRATION: This trial is registered at the database www.clinicaltrials.gov . https://clinicaltrials.gov/ct2/show/NCT02390349?term=EuroPharma&rank=1 . Study registration number: NCT02390349 . [Mh] Termos MeSH primário: Curcumina Osteoartrite/tratamento farmacológico Triterpenos [Mh] Termos MeSH secundário: Idoso Curcumina/administração & dosagem Curcumina/efeitos adversos Curcumina/uso terapêutico Método Duplo-Cego Feminino Seres Humanos Masculino Meia-Idade Osteoartrite/fisiopatologia Amplitude de Movimento Articular Triterpenos/administração & dosagem Triterpenos/efeitos adversos Triterpenos/uso terapêutico [Pt] Tipo de publicação: CLINICAL TRIAL, PHASE II; COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL [Nm] Nome de substância: 0 (Triterpenes); 631-69-6 (boswellic acid); IT942ZTH98 (Curcumin) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180216 [Lr] Data última revisão: 180216 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180111 [Cl] Clinical Trial: ClinicalTrial [St] Status: MEDLINE [do] DOI: 10.1186/s12906-017-2062-z

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