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[PMID]:27776225
[Au] Autor:Matt F; Cole-Hunter T; Donaire-Gonzalez D; Kubesch N; Martínez D; Carrasco-Turigas G; Nieuwenhuijsen M
[Ad] Endereço:ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Rudolf Boehm Institute of Pharmacology and Toxicology, PGS Toxicology and Environmental Protection, University of Leipzig, Leipzig, Germany; Biological Safety & Risk Management, Institute Straumann AG, Basel,
[Ti] Título:Acute respiratory response to traffic-related air pollution during physical activity performance.
[So] Source:Environ Int;97:45-55, 2016 12.
[Is] ISSN:1873-6750
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Physical activity (PA) has beneficial, whereas exposure to traffic related air pollution (TRAP) has adverse, respiratory effects. Few studies, however, have examined if the acute effects of TRAP upon respiratory outcomes are modified depending on the level of PA. OBJECTIVES: The aim of our study was to disentangle acute effects of TRAP and PA upon respiratory outcomes and assess the impact of participants TRAP pre-exposure. METHODS: We conducted a real-world crossover study with repeated measures of 30 healthy adults. Participants completed four 2-h exposure scenarios that included either rest or intermittent exercise in high- and low-traffic environments. Measures of respiratory function were collected at three time points. Pre-exposure to TRAP was ascertained from land-use-modeled address-attributed values. Mixed-effects models were used to estimate the impact of TRAP and PA on respiratory measures as well as potential effect modifications. RESULTS: We found that PA was associated with a statistically significant increases of FEV (48.5mL, p=0.02), FEV /FVC (0.64%, p=0.005) and FEF (97.8mL, p=0.02). An increase in exposure to one unit (1µg/m ) of PM was associated with a decrease in FEV (-1.31mL, p=0.02) and FVC (-1.71mL, p=0.01), respectively. On the other hand, for an otherwise equivalent exposure an increase of PA by one unit (1%Heart rate max) was found to reduce the immediate negative effects of particulate matter (PM) upon PEF (PM , 0.02L/min, p=0.047; PM , 0.02L/min p=0.02; PM , 0.03L/min, p=0.02) and the several hours delayed negative effects of PM upon FVC (PM , 0.11mL, p=0.02). The negative impact of exposure to TRAP constituents on FEV /FVC and PEF was attenuated in those participants with higher TRAP pre-exposure levels. CONCLUSIONS: Our results suggest that associations between various pollutant exposures and respiratory measures are modified by the level of PA during exposure and TRAP pre-exposure of participants.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/toxicidade
Poluição do Ar/efeitos adversos
Exercício
Material Particulado/toxicidade
Respiração/efeitos dos fármacos
Emissões de Veículos/toxicidade
[Mh] Termos MeSH secundário: Adulto
Poluentes Atmosféricos/análise
Poluição do Ar/análise
Estudos Cross-Over
Feminino
Frequência Cardíaca/efeitos dos fármacos
Seres Humanos
Masculino
Meia-Idade
Modelos Teóricos
Veículos Automotores
Material Particulado/análise
Testes de Função Respiratória
Emissões de Veículos/análise
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Particulate Matter); 0 (Vehicle Emissions)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180311
[Lr] Data última revisão:
180311
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:29447167
[Au] Autor:Bryant RA; Hutanamon T
[Ad] Endereço:University of New South Wales, New South Wales, Australia.
[Ti] Título:Activating attachments enhances heart rate variability.
[So] Source:PLoS One;13(2):e0151747, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Although activating mental representations of attachment figures is beneficial for psychological health, there is a paucity of knowledge of the underlying mechanisms. We investigated how priming attachment figures may modulate parasympathetic stress response. Participants (N = 62) with varying degrees of attachment security underwent a cold pressor test, and then imagined an attachment or non-attachment figure. Heart rate variability was assessed throughout the study. Participants with low avoidant attachment levels displayed less negative affect and greater heart rate variability following the attachment prime than those who imagined the non-attachment prime. This beneficial effect of attachment priming was not observed in participants with high avoidant attachment levels. These findings highlight that activating attachment representations can enhance the parasympathetic stress response in people with secure attachment styles, and provides one explanation for the psychological benefits of attachment proximity.
[Mh] Termos MeSH primário: Frequência Cardíaca
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Masculino
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180216
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0151747


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[PMID]:28743567
[Au] Autor:Junior JFCR; Silva AS; Cardoso GA; Silvino VO; Martins MCC; Santos MAP
[Ad] Endereço:Universidade Federal do Piauí(UFPI), Campus Universitário Ministro Petrônio Portella, Department of Biophysics and Physiology, Teresina, PI, Brazil.
[Ti] Título:Androgenic-anabolic steroids inhibited post-exercise hypotension: a case control study.
[So] Source:Braz J Phys Ther;22(1):77-81, 2018 Jan - Feb.
[Is] ISSN:1809-9246
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: There is evidence of hypertensive effects caused by anabolic androgenic steroids (AAS). A single exercise session promotes the acute reduction of blood pressure, but the effects of AAS on this phenomenon are unknown. OBJECTIVES: To investigate the post-exercise blood pressure response in androgenic-anabolic steroid users. METHODS: Thirteen AAS users (23.9±4.3 years old) and sixteen controls (22.1±4.5 years old) performed a session of aerobic exercise. Heart rate and blood pressure were assessed before exercise and during a 60min post-exercise resting period. Repeated ANOVA measures were used to determine differences between the groups. RESULTS: While the control group had a significant reduction in post-exercise systolic blood pressure of up to 13.9±11.6mmHg at 40min, this phenomenon was limited among AAS users who reached a maximum of 6.2±11.5mmHg at 60min. The between groups comparison revealed significant higher post-exercise hypotension (PEH) for the control group at 30min (-12.9±14.1mmHg versus -2.9±7.6mmHg), 40min (-13.9±11.6mmHg versus -2.5±8.3mmHg), 50min (-13.9±13.9mmHg versus -5.0±7.9mmHg) and 60min (-12.5±12.8mmHg versus -6.2±11.5mmHg). There was no significant diastolic PEH in any of the groups. CONCLUSIONS: This study demonstrated impaired systolic post-exercise hypotension as a new adverse effect of AAS usage.
[Mh] Termos MeSH primário: Anabolizantes/uso terapêutico
Androgênios/uso terapêutico
Hipotensão Pós-Exercício/prevenção & controle
Hipotensão Pós-Exercício/fisiopatologia
Congêneres da Testosterona/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Anabolizantes/farmacologia
Androgênios/farmacologia
Pressão Sanguínea/efeitos dos fármacos
Estudos de Casos e Controles
Frequência Cardíaca/efeitos dos fármacos
Frequência Cardíaca/fisiologia
Seres Humanos
Sístole/efeitos dos fármacos
Sístole/fisiologia
Congêneres da Testosterona/farmacologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anabolic Agents); 0 (Androgens); 0 (Testosterone Congeners)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE


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[PMID]:27776979
[Au] Autor:Salman IM; Hildreth CM; Phillips JK
[Ad] Endereço:Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia. Electronic address: ibraheem_muhammed@yahoo.com.
[Ti] Título:Chronic kidney disease impairs renal nerve and haemodynamic reflex responses to vagal afferent input through a central mechanism.
[So] Source:Auton Neurosci;204:65-73, 2017 05.
[Is] ISSN:1872-7484
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:We investigated age- and sex-related changes in reflex renal sympathetic nerve activity (RSNA) and haemodynamic responses to vagal afferent stimulation in a rodent model of chronic kidney disease (CKD). Using anaesthetised juvenile (7-8weeks) and adult (12-13weeks) Lewis Polycystic Kidney (LPK) and Lewis control rats of either sex (n=63 total), reflex changes in RSNA, heart rate (HR) and mean arterial pressure (MAP) to vagal afferent stimulation (5-s train, 4.0V, 2.0-ms pulses, 1-16Hz) were measured. In all groups, stimulation of the vagal afferents below 16Hz produced frequency-dependent reductions in RSNA, HR and MAP, while a 16Hz stimulus produced an initial sympathoinhibition followed by sympathoexcitation. In juvenile LPK versus age-matched Lewis, sympathoinhibition was reduced when responses were expressed as % baseline (P<0.05), but not as microvolts, while bradycardic responses were greater. Reflex depressor responses were greater (P=0.015) only in juvenile female LPK. In adult LPK, reflex sympathoinhibition (%) was blunted (P<0.05), and an age-related decline apparent (when expressed as microvolts). Reflex reductions in HR and MAP were only diminished (P<0.05) in adult female LPK versus age-matched Lewis. Peak reflex sympathoexcitation at 16Hz did not differ between groups; however, area under the curve values were greater in the LPK versus Lewis (overall, 9±1 versus 19±3µVs, P<0.05) irrespective of age, suggestive of enhanced sympathoexcitatory drive in the LPK. Our data demonstrates a progressive deficit in the central processing of vagal afferent input and a differential sex influence on reflex regulation of autonomic function and blood pressure homeostasis in CKD.
[Mh] Termos MeSH primário: Hemodinâmica/fisiologia
Rim/inervação
Rim/fisiopatologia
Reflexo/fisiologia
Insuficiência Renal Crônica/fisiopatologia
Nervo Vago/fisiopatologia
[Mh] Termos MeSH secundário: Vias Aferentes/fisiopatologia
Animais
Área Sob a Curva
Pressão Sanguínea/fisiologia
Estudos de Coortes
Modelos Animais de Doenças
Feminino
Frequência Cardíaca/fisiologia
Masculino
Ratos Endogâmicos Lew
Especificidade da Espécie
Sistema Nervoso Simpático/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


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[PMID]:29397598
[Au] Autor:Yu C; Liu DW; Wang XT; He HW; Pan P; Xing ZQ
[Ad] Endereço:Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
[Ti] Título:[The clinical significance of microcirculation and oxygen metabolism evaluation in acute kidney injury assessment in patients with septic shock after resuscitation].
[So] Source:Zhonghua Nei Ke Za Zhi;57(2):123-128, 2018 Feb 01.
[Is] ISSN:0578-1426
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To evaluate the value of microcirculation and oxygen metabolism evaluation (MicrOME) in acute kidney injury(AKI) evaluation in patients with septic shock after resuscitation. Consecutive patients with septic shock after resuscitation and mechanical ventilation were enrolled from October 2016 to February 2017 in ICU at Peking Union Medical College Hospital.Patients were divided into 3 groups based on 10 min transcutaneous oxygen challenge test transcutaneous partial pressure of oxygen(PtcO(2))and venoarterial pressure of carbon dioxide difference (Pv-aCO(2)) /arteriovenous O(2) content difference (Ca-vO(2)) by blood gas analysis, i.e. group A [ΔPtcO(2)>66 mmHg(1 mmHg=0.133 kPa) and Pv-aCO(2)/Ca-vO(2)≤1.23], group B (ΔPtcO(2)≤66 mmHg), group C (ΔPtcO(2)>66 mmHg and Pv-aCO(2)/Ca-vO(2)>1.23). Heart rate,mean arterial pressure,central venous pressure,noradrenaline dose,lactate,Pv-aCO(2),Ca-vO(2), lactate clearance, central venous oxygen saturation(ScvO(2)) and liquid equilibrium were assessed after resuscitation.AKI staging based on Kidney Disease Global Improving Outcomes (KDIGO) clinical practice guideline was analyzed. The predictive value of lactate, ScvO(2), Pv-aCO(2)/Ca-vO(2) to progression of AKI after resuscitation was determined using receiver operating characteristic(ROC)curve analysis. A total of 49 septic shock patients were enrolled including 30 males and 19 females with mean age of (61.10±17.10)years old.There were 19 patients in group A,21 patients in group B, and 9 patients in group C. Acute physiology and chronic health evaluation â…¡ score was 20.92±7.19 and sequential organ failure assessment score 12.02±3.28. There were 4 patients with AKI and 1 progressed in group A, 11 patients with AKI and 2 progressed in group B, 6 patients with AKI and 4 progressed in group C. The cutoff value of Pv-aCO(2)/Ca-vO(2) was equal or more than 2.20 for predicting progression of AKI, resulting in a sensitivity of 85.7% and a specificity of 73.8%. MicrOME is a significant parameter to predict the progression of AKI in patients with septic shock after resuscitation. Pv-aCO(2)/Ca-vO(2) is also a good predictive factor.
[Mh] Termos MeSH primário: Lesão Renal Aguda/complicações
Pressão Venosa Central
Microcirculação
Oxigênio/metabolismo
Choque Séptico/complicações
[Mh] Termos MeSH secundário: Lesão Renal Aguda/sangue
Adulto
Idoso
Dióxido de Carbono
Feminino
Frequência Cardíaca
Seres Humanos
Ácido Láctico
Masculino
Meia-Idade
Norepinefrina
Troca Gasosa Pulmonar
Curva ROC
Respiração Artificial
Ressuscitação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
142M471B3J (Carbon Dioxide); 33X04XA5AT (Lactic Acid); S88TT14065 (Oxygen); X4W3ENH1CV (Norepinephrine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180206
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0578-1426.2018.02.008


  6 / 149617 MEDLINE  
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[PMID]:29237522
[Au] Autor:Yi LF; Wen HX; Qiu M; Cao XX
[Ad] Endereço:Department of Electrocardiogram, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China. 380947312@qq.com.
[Ti] Título:[An analysis of cardiac autonomic nerve function in girls with idiopathic central precocious puberty].
[So] Source:Zhongguo Dang Dai Er Ke Za Zhi;19(12):1239-1242, 2017 Dec.
[Is] ISSN:1008-8830
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To investigate the cardiac autonomic nerve function in girls with idiopathic central precocious puberty (ICPP). METHODS: A total of 66 girls with ICPP were enrolled, among whom 36 were obese and 30 were not obese. A total of 68 age-matched healthy girls (normal controls) and 51 girls with simple obesity were enrolled as controls. All the subjects underwent 24-hour ambulatory electrocardiography, and deceleration capacity of heart rate (DC), acceleration capacity of heart rate (AC), and heart rate variability (HRV), and body mass index (BMI) were compared between groups. RESULTS: Compared with the normal control group, the ICPP group had significantly lower DC, standard deviation of normal-to-normal R-R intervals (SDNN), standard deviation of the average normal-to-normal intervals (SDANN), root mean square of successive differences (RMSSD), and high-frequency power (HF) and significantly higher AC and BMI. The ICPP group had significantly lower RMSSD and BMI than the simple obesity group (P<0.05). Compared with the ICPP girls without obesity, those with obesity had significantly lower DC, RMSSD, and HF and significantly higher AC and BMI (P<0.05). CONCLUSIONS: Cardiac autonomic dysfunction is seen in girls with ICPP, especially those with obesity, mainly presenting with reduced vagal tone.
[Mh] Termos MeSH primário: Sistema Nervoso Autônomo/fisiopatologia
Coração/inervação
Puberdade Precoce/fisiopatologia
[Mh] Termos MeSH secundário: Índice de Massa Corporal
Criança
Pré-Escolar
Feminino
Frequência Cardíaca/fisiologia
Seres Humanos
Obesidade/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE


  7 / 149617 MEDLINE  
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[PMID]:29216963
[Au] Autor:Hassan A; Chen QB; Jiang T; Lyu BY; Li N; Li S; Shangguan ZY; Li YT; Jun ZL; Luo Q; Chen XY; Wang YY; Zeng CC; Yang J; Tahir MS
[Ad] Endereço:College of Landscape Architecture, Sichuan Agricultural University, Chengdu 611130, Sichuan, China.
[Ti] Título:Psychophysiological Effects of Bamboo Plants on Adults.
[So] Source:Biomed Environ Sci;30(11):846-850, 2017 Nov.
[Is] ISSN:0895-3988
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The present study was conducted to clarify the psychophysiological relaxation effects of viewing bamboo on university students. Forty healthy Chinese participants enrolled in this study to clarify the psychophysiological relaxation effects of viewing bamboo. The effects of visual stimulation using a pot both with and without a bamboo were recorded by measuring the student's blood pressure, EEG and STAI. We observed that viewing bamboo plants resulted in significantly lower systolic (female, P < 0.001; male, P < 0.001; P < 0.05) and diastolic (female, P < 0.001; male, P < 0.001; P < 0.05) blood pressures, but no changes in the pulse rate (female, P = 0.09; male, P = 0.07; P > 0.05) were observed. The results of the EEG analysis indicated brainwave variation (all P < 0.05) and lower anxiety scores (P < 0.01) after 3 min of viewing bamboo compared with the control. These findings indicate that visual stimulation with bamboo plants induced psychophysiological relaxation effects on adults.
[Mh] Termos MeSH primário: Bambusa
Pressão Sanguínea/fisiologia
Frequência Cardíaca/fisiologia
Relaxamento
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE
[do] DOI:10.3967/bes2017.114


  8 / 149617 MEDLINE  
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[PMID]:28465299
[Au] Autor:Jacobs L; Efremov L; Ferreira JP; Thijs L; Yang WY; Zhang ZY; Latini R; Masson S; Agabiti N; Sever P; Delles C; Sattar N; Butler J; Cleland JGF; Kuznetsova T; Staessen JA; Zannad F; Heart "OMics" in AGEing (HOMAGE) investigators
[Ad] Endereço:Research Unit of Hypertension and Cardiovascular Epidemiology, Studies Coordinating Centre, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium.
[Ti] Título:Risk for Incident Heart Failure: A Subject-Level Meta-Analysis From the Heart "OMics" in AGEing (HOMAGE) Study.
[So] Source:J Am Heart Assoc;6(5), 2017 May 02.
[Is] ISSN:2047-9980
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To address the need for personalized prevention, we conducted a subject-level meta-analysis within the framework of the Heart "OMics" in AGEing (HOMAGE) study to develop a risk prediction model for heart failure (HF) based on routinely available clinical measurements. METHODS AND RESULTS: Three studies with elderly persons (Health Aging and Body Composition [Health ABC], [PREDICTOR], and Prospective Study of Pravastatin in the Elderly at Risk [PROSPER]) were included to develop the HF risk function, while a fourth study (Anglo-Scandinavian Cardiac Outcomes Trial [ASCOT]) was used as a validation cohort. Time-to-event analysis was conducted using the Cox proportional hazard model. Incident HF was defined as HF hospitalization. The Cox regression model was evaluated for its discriminatory performance (area under the receiver operating characteristic curve) and calibration (Grønnesby-Borgan χ statistic). During a follow-up of 3.5 years, 470 of 10 236 elderly persons (mean age, 74.5 years; 51.3% women) developed HF. Higher age, BMI, systolic blood pressure, heart rate, serum creatinine, smoking, diabetes mellitus, history of coronary artery disease, and use of antihypertensive medication were associated with increased HF risk. The area under the receiver operating characteristic curve of the model was 0.71, with a good calibration (χ 7.9, =0.54). A web-based calculator was developed to allow easy calculations of the HF risk. CONCLUSIONS: Simple measurements allow reliable estimation of the short-term HF risk in populations and patients. The risk model may aid in risk stratification and future HF prevention strategies.
[Mh] Termos MeSH primário: Envelhecimento
Técnicas de Apoio para a Decisão
Insuficiência Cardíaca/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Idoso
Idoso de 80 Anos ou mais
Envelhecimento/sangue
Área Sob a Curva
Biomarcadores/sangue
Pressão Sanguínea
Distribuição de Qui-Quadrado
Comorbidade
Feminino
Avaliação Geriátrica
Insuficiência Cardíaca/sangue
Insuficiência Cardíaca/diagnóstico
Insuficiência Cardíaca/fisiopatologia
Frequência Cardíaca
Hospitalização
Seres Humanos
Incidência
Estilo de Vida
Modelos Lineares
Masculino
Meia-Idade
Análise Multivariada
Valor Preditivo dos Testes
Prognóstico
Modelos de Riscos Proporcionais
Curva ROC
Medição de Risco
Fatores de Risco
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


  9 / 149617 MEDLINE  
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[PMID]:29465596
[Au] Autor:Chen B; Wang Y; He Z; Wang D; Yan X; Xie P
[Ad] Endereço:The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine.
[Ti] Título:Tianma Gouteng decoction for essential hypertension: Protocol for a systematic review and meta-analysis.
[So] Source:Medicine (Baltimore);97(8):e9972, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Essential hypertension is one of the most common chronic diseases, as well as one of the leading risk factors for cardio-cerebrovascular diseases. Tianma Gouteng decoction has been commonly used in clinical practice for patients with essential hypertension. It is important to update the search and evaluation to provide the best available evidence for essential hypertension. Here, we provide a protocol to evaluate the efficacy and safety of Tianma Gouteng decoction (TGD) for essential hypertension. METHODS: Retrieve literature on the TGD treatment for essential hypertension in the databases including PubMed, Cochrane Library, EMBASE, Chinese Biomedical database (CBM), Chinese National Knowledge Infrastructure (CNKI), Wanfang database, and Chinese Science and Technology Periodical database (VIP) on computer. The literature to be collected will be those published from the time when the respective databases were established to January 2018. The therapeutic effects according to the blood pressure (BP) will be accepted as the primary outcomes. We will use RevMan V.5.3 software as well to compute the data synthesis carefully when a meta-analysis is allowed. RESULTS: This study will provide a high-quality synthesis of current evidence of TGD for essential hypertension from several aspects including BP, life quality, heart rate, and adverse events. CONCLUSION: The conclusion of our systematic review will provide evidence to judge whether TGD is an effective intervention for patient with essential hypertension. PROSPERO REGISTRATION NUMBER: PROSPERO CRD 42018082319.
[Mh] Termos MeSH primário: Anti-Hipertensivos/uso terapêutico
Medicamentos de Ervas Chinesas/uso terapêutico
Hipertensão Essencial/tratamento farmacológico
[Mh] Termos MeSH secundário: Pressão Sanguínea/efeitos dos fármacos
Protocolos Clínicos
Frequência Cardíaca/efeitos dos fármacos
Seres Humanos
Qualidade de Vida
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (Antihypertensive Agents); 0 (Drugs, Chinese Herbal); 0 (tianma gouteng)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180222
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009972


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[PMID]:29465549
[Au] Autor:Marques NDSF; Abreu LC; Santos BVD; Neto CFR; Silva JRCD; Braga KKS; Uchôa KDS; Moraes LMS; Ferreira LCP; Ribeiro NG; Santos SLD; Silva TAD; Andrade PE; Raimundo RD
[Ad] Endereço:Laboratory of Study Design and Scientific Writing of the Faculty of Medicine of ABC, Prince of Wales, Santo André/SP-CEP, Brazil.
[Ti] Título:Cardiorespiratory parameters and glycated hemoglobin of patients with type 2 diabetes after a rehabilitation program.
[So] Source:Medicine (Baltimore);97(8):e9321, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Cardiovascular autonomic dysfunction reflex of the pathophysiology of diabetes mellitus (DM) favors an increase in morbidity and mortality related to cardiovascular events, and for this reason has been one of the most studied clinical entities. METHOD: An experimental study of a randomized clinical trial type was therefore proposed to analyze the hemodynamic and glycemic response after the practice of a rehabilitation program in patients with type 2 diabetes mellitus (T2DM). In this clinical trial the patients will initially be submitted to an evaluation protocol that consists of assessing blood pressure, heart rate, Borg scale, respiratory rate, oxygen saturation, distance traveled through the 6-minute walk test, quality of life questionnaire, Pittsburgh sleep quality questionnaire, and still glycated hemoglobin and heart rate variability through the cardiofrequency meter. After careful evaluation of the patients, they will be submitted to a metabolic rehabilitation program composed of aerobic and resisted exercises, performed for 12 weeks, in 3 weekly meetings of 60 minutes each. With such evaluations, it will be possible to construct with evidence that it is possible to work safer metabolic rehabilitation programs in patients with T2DM or other diseases that generate cardiovascular risks, guaranteeing them an improvement in cardiorespiratory fitness, hemodynamic and glycemic variables, allowing improvement of the quality of life. ETHICS AND DISSEMINATION: The protocol is approved by the host institution's ethics committee under the number 1.616.721. Results will be disseminated via peer-reviewed journal articles and conferences. This clinical trial is registered at ClinicalTrials.gov identifier: NCT3094767.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2
Exercício/fisiologia
Hemoglobina A Glicada/análise
Treinamento de Resistência/métodos
[Mh] Termos MeSH secundário: Adulto
Glicemia/análise
Pressão Sanguínea
Protocolos Clínicos
Diabetes Mellitus Tipo 2/sangue
Diabetes Mellitus Tipo 2/fisiopatologia
Diabetes Mellitus Tipo 2/reabilitação
Feminino
Frequência Cardíaca
Seres Humanos
Masculino
Consumo de Oxigênio
Qualidade de Vida
Sono
Inquéritos e Questionários
Resultado do Tratamento
Teste de Caminhada
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Glycated Hemoglobin A); 0 (hemoglobin A1c protein, human)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180222
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009321



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