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[PMID]:27207683
[Au] Autor:Canatan D; Delibas S
[Ad] Endereço:a Mediterranean Blood Diseases Foundation, Hemoglobinopathy Diagnosis Center , Antalya , Turkey.
[Ti] Título:Report on Ten Years' Experience of Premarital Hemoglobinopathy Screening at a Center in Antalya, Southern Turkey.
[So] Source:Hemoglobin;40(4):273-6, 2016 Aug.
[Is] ISSN:1532-432X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Thalassemia and hemoglobinopathies are a major public health problem in Turkey. Hemoglobinopathy prevention programs (HPPs) were started in 33 provinces situated in Thrace, Marmara, Aegean, Mediterranean and South Eastern regions of Turkey in 2003. A premarital hemoglobinopathy test is mandatory and free of charge in this program. According to the Ministry of Health reports, 46 first level hemoglobinopathy diagnostic centers were established for premarital tests. Within the last 10 years, approximately 79.0% of married individuals per year were screened by the centers. While the percentage of premarital screening tests was 30.0% of all couples in 2003, it reached 86.0% in 2013. The number of newborn with thalassemia and hemoglobinopathies were 272 in 2002 and dropped to 25 in 2013. There has been a 90.0% reduction in affected births. Our hemoglobinopathy diagnostic center was established in 2003 and licensed by the Ministry of Health in 2004. We studied a total of 89,981 blood samples from premarital tests for 10 years and the incidence of ß- and α-thalassemia (ß- and α-thal) trait was found to be 6.57 and 3.56%, respectively. The distribution of the most common abnormal hemoglobins (Hbs) was: Hb S (HBB: c.20A > T) (0.31%), Hb D-Los Angeles (HBB: c.364G > C) (0.15%), Hb G-Coushatta (HBB: c.68A > C) (0.06%) and Hb E (HBB: c.79G > A) (0.02%). A total of 60 couples, both carrying ß-thal trait, were directed to the prenatal diagnosis (PND) center in 10 years. The premarital hemoglobinopathy screening program is running successfully at our center and other centers in Turkey.
[Mh] Termos MeSH primário: Hemoglobinopatias/diagnóstico
Programas de Rastreamento/estatística & dados numéricos
Exames Pré-Nupciais
[Mh] Termos MeSH secundário: Testes Genéticos/estatística & dados numéricos
Hemoglobinas Anormais/análise
Seres Humanos
Incidência
Exames Pré-Nupciais/estatística & dados numéricos
Diagnóstico Pré-Natal
Turquia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hemoglobins, Abnormal)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170223
[Lr] Data última revisão:
170223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160522
[St] Status:MEDLINE
[do] DOI:10.3109/03630269.2016.1170030


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[PMID]:26821551
[Au] Autor:Alkhaldi SM; Khatatbeh MM; Berggren VE; Taha HA
[Ad] Endereço:a Department of Family and Community Medicine , Faculty of Medicine, University of Jordan , Amman , Jordan.
[Ti] Título:Knowledge and Attitudes Toward Mandatory Premarital Screening Among University Students in North Jordan.
[So] Source:Hemoglobin;40(2):118-24, 2016.
[Is] ISSN:1532-432X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A mandatory National Premarital Thalassemia Screening Program was implemented in Jordan in 2004. This cross-sectional study aimed to assess the knowledge and attitudes of university students in North Jordan toward this program. Data was collected from 542 students from four universities (two public and two private universities) located in North Jordan, using a structured questionnaire. Results of t-test and analysis of variance (ANOVA) showed that while respondents had adequate knowledge of and positive attitudes toward the premarital screening program, there was still a lack of knowledge about the disease itself. Nearly half the respondents were under the impression that ß-thalassemia (ß-thal) is a disease that can be treated simply. One-third of the respondents believed that if both partners were carriers of ß-thal they should proceed with marriage. Negative attitude was revealed when many respondents believed that diagnosing a family member as a carrier affects other family members' future marriage opportunities. Significant associations were detected between the knowledge scores and gender, urban/rural residence, and the university where the students were enrolled. Students in private universities showed significantly lower attitude scores. Consideration of prenatal diagnostic services as part of a ß-thal prevention program is necessary. It would also be helpful to include information about ß-thal as a preventable inherited illness with a severe debilitating impact on the family in the high school curriculum. There is also a need for social marketing of the program.
[Mh] Termos MeSH primário: Conhecimentos, Atitudes e Prática em Saúde
Exames Pré-Nupciais
Estudantes
Talassemia/epidemiologia
Universidades
[Mh] Termos MeSH secundário: Adolescente
Adulto
Análise de Variância
Estudos Transversais
Feminino
Seres Humanos
Jordânia/epidemiologia
Masculino
Programas de Rastreamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160130
[St] Status:MEDLINE
[do] DOI:10.3109/03630269.2015.1135159


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[PMID]:26633123
[Au] Autor:Fiestas E; García-Fernández L; Benites C
[Ti] Título:[Transgressions to the HIV voluntary counseling and testing in Peru: the case of the requirement for civil marriage].
[Ti] Título:Transgresiones a la voluntariedad de la prueba de VIH en Perú: el caso del requisito para contraer matrimonio civil..
[So] Source:Rev Chilena Infectol;32(5):596, 2015 Oct.
[Is] ISSN:0717-6341
[Cp] País de publicação:Chile
[La] Idioma:spa
[Mh] Termos MeSH primário: Infecções por HIV/prevenção & controle
Testes Obrigatórios/legislação & jurisprudência
Exames Pré-Nupciais
[Mh] Termos MeSH secundário: Aconselhamento
Feminino
Seres Humanos
Masculino
Casamento
Peru
[Pt] Tipo de publicação:LETTER
[Em] Mês de entrada:1606
[Cu] Atualização por classe:151204
[Lr] Data última revisão:
151204
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151204
[St] Status:MEDLINE


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[PMID]:26440830
[Au] Autor:Nosheen A; Ahmad H; Qayum I; Siddiqui N; Abbasi FM; Iqbal MS; Inamullah; Aziz ud Din
[Ad] Endereço:Department of Genetics, Hazara University, Mansehra, Pakistan.
[Ti] Título:Premarital genetic screening for beta thalassemia carrier status of indexed families using HbA2 electrophoresis.
[So] Source:J Pak Med Assoc;65(10):1047-9, 2015 Oct.
[Is] ISSN:0030-9982
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To devise a strategy for prevention of beta thalassemia in newborns through reliable screening of indexed families. METHODS: The cross-sectional study was conducted over six months in 2011 and comprised blood samples collected from subjects belonging to different ethnic groups from families of beta thalassemia major children registered with the Abbottonian Medical Association Blood Care Centre, Abbottabad, in Pakistan's Khyber Pakhtunkhwa province. Electrophoretic separation of human haemoglobin like A, F, S and C was done and then haemoglobin in the gel was immobilised in a fixative solution and the gel was dried to a film. Haemoglobin pattern was visualised by staining the film with a protein-specific stain. The pattern was quantified by densitometry. RESULTS: Of the 98 samples, 57(58.2%) had b-thalassemia trait with elevated haemoglobin alpha 2 level, and 41(41.8%) had normal level. Out of the 57 carriers, 33(57.89%) were males and 24(42.10%) were females. Mean age of carriers was 11.65±6.25 years compared to 10.93±7.75 in normal patients. Mean haemoglobin alpha 2 level of carriers was 5.2±0.56% compared to 2.34±0.57% in normal subjects. CONCLUSIONS: Carrying out mass screening programmes throughout Pakistan for the detection of thalassemia carriers and providing them the benefit of marriage counselling may decrease the incidence of thalassemia Major.
[Mh] Termos MeSH primário: Triagem de Portadores Genéticos
Testes Genéticos
Exames Pré-Nupciais
Talassemia beta/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Estudos Transversais
Eletroforese
Feminino
Heterozigoto
Seres Humanos
Lactente
Masculino
Paquistão
Adulto Jovem
Talassemia beta/genética
Talassemia beta/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151007
[St] Status:MEDLINE


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[PMID]:26080872
[Au] Autor:Zhou YB; Luo SS; Li HT; Gao YQ; Liu JM
[Ad] Endereço:Office for National Maternal & Child Health Statistics of China, Peking University School of Public Health, Beijing 100191, China; Institute of Reproductive & Child Health, Ministry of Health Key Laboratory of Reproductive Health, Beijing 100191, China; Department of Epidemiology & Biost
[Ti] Título:[Secular trends of premarital medical examination in China during 1996 and 2013].
[So] Source:Beijing Da Xue Xue Bao Yi Xue Ban;47(3):437-42, 2015 Jun 18.
[Is] ISSN:1671-167X
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To describe the secular trends of premarital medical examination (PME) in China during 1996 and 2013 and to assess the impacts of national health policies on the PME rate. METHODS: The information on marriage and PME for districts and counties in 31 provinces of China was annually collected by the Office for National Maternal & Child Health Statistics of China, and the information on the health policies was from official governmental websites. According to the main health policies, the calendar years were categorized into 3 periods: 1996 to 2003 was mandatory PME period; 2004 to 2008 was encouraged voluntary PME period; and 2009 to 2013 was free-paid voluntary PME period. RESULTS: During the 18-year period, 284 242 719 people were registered for a marriage in which 107 198 795 were examined, giving the PME rate of 37.7%. During the mandatory PME period, the rate ranged 52.7%-67.7% with an average of 60.9% (urban 71.5%, and rural 51.7%). In 2004, the first year when the PME became voluntary, the rate was abruptly dropped to 2.6%, and thereafter gradually increased to 11.5% in 2008. As the policies of the free-paid voluntary PME were subsequently issued, the rate was quickly increased to 52.3% (urban 49.8%, and rural 54.6%) in 2013. The increasing trend was consistently observed both in urban and rural areas, and across East, Middle, West, and Northeast economical regions. However, the rates differed greatly among provinces. In 2013, 5 provinces had rates of >90% (Guangxi 97.5%, Fujian 96.0%, Ningxia 95.4%, Zhejiang 93.4% and Anhui 90.1%), whereas some provinces were stuck at a low rate, including developed and underdeveloped provinces/cities. The PME rate in 2013 was 27.4% for Shanghai, 25.5% for Guangdong, 12.4% for Chongqing, 5.8% for Beijing and 4.6% for Tianjin. Underdeveloped provinces were Guizhou (6.4%) and Qinghai (1.8%). CONCLUSION: As various national policies to promote voluntary PME were issued, the PME rate was significantly increased after a sharp decline, though it varied greatly by provinces. For provinces with high PME rate, PME-related health benefits need to be evaluated; for provinces with low rate, it is of important practical significance to explore a cost-effective health service model that is likely incorporated with pre-pregnancy examination.
[Mh] Termos MeSH primário: Exames Pré-Nupciais/tendências
[Mh] Termos MeSH secundário: China
Política de Saúde
Seres Humanos
Casamento
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1510
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150618
[St] Status:MEDLINE


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[PMID]:25556384
[Au] Autor:Hayatbakhsh MM; Darvish Moghaddam S; Zahedi MJ; Shafiei M; Khalily Zade M; Assare M
[Ad] Endereço:Internal Medicine Department, Afzalipoor Hospital, Kerman University of Medical Sciences, Kerman, Iran. mahkhalilyzade@gmail.com, mkhalili@kmu.ac.ir.
[Ti] Título:Seroprevalence of hepatitis B before marriage: a study on marriage candidates in the Southeast of Iran; is it worthy of consideration?
[So] Source:Arch Iran Med;18(1):34-8, 2015 Jan.
[Is] ISSN:1735-3947
[Cp] País de publicação:Iran
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Hepatitis B virus infection is one of the most common causes of acute and chronic hepatitis worldwide. Furthermore, since most people with hepatitis B virus are asymptomatic, timely diagnosis is important for prevention. This study has evaluated the prevalence of Hepatitis B seromarkers in marriage candidates. DESIGN: In this Cross-sectional study, 370 marriage volunteers selected by the simple sampling method were investigated in 2011 - 2012. RESULTS: A total of 185 men and 185 women were investigated. Mean Age of participants was 24.7 years. The prevalence rates of hepatitis B surface antigen (HBsAg), anti hepatitis B surface antibody (anti-HBs) and anti-hepatitis B core antibody (anti-HBc) were 1.1%, 47.6% and 8.9% respectively. Frequency of HBsAg was 0.5% and 1.6% in men and women respectively. The prevalence of anti-HBs was 43.8% in men and 51.45% in women. Anti-HBs was more common in young people and those with higher levels of education and positive history of vaccination. The prevalence of anti-HBc was 8.1% and 9.7% in men and women respectively. CONCLUSION: Although Kerman is a low endemic area, due to the high risk of transmission to the spouse and offspring, screening for HBV study before marriage is recommended.
[Mh] Termos MeSH primário: Hepatite B/epidemiologia
Casamento/estatística & dados numéricos
Exames Pré-Nupciais
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Estudos Transversais
Escolaridade
Feminino
Hepatite B/imunologia
Hepatite B/prevenção & controle
Anticorpos Anti-Hepatite B
Antígenos do Núcleo do Vírus da Hepatite B/imunologia
Antígenos de Superfície da Hepatite B/sangue
Antígenos de Superfície da Hepatite B/imunologia
Vacinas contra Hepatite B/uso terapêutico
Seres Humanos
Irã (Geográfico)/epidemiologia
Masculino
Meia-Idade
Estudos Soroepidemiológicos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hepatitis B Antibodies); 0 (Hepatitis B Core Antigens); 0 (Hepatitis B Surface Antigens); 0 (Hepatitis B Vaccines)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:150105
[Lr] Data última revisão:
150105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150106
[St] Status:MEDLINE
[do] DOI:0151801/AIM.009


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[PMID]:22500035
[Au] Autor:Wang P; Fang M; Wang X; VanderWeele TJ
[Ad] Endereço:Wuhan University, Wuhan, China.
[Ti] Título:Levels of satisfaction and factors influencing satisfaction for medical premarital examinations in Hubei, Middle China.
[So] Source:Asia Pac J Public Health;27(2):NP2531-41, 2015 Mar.
[Is] ISSN:1941-2479
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: When the mandatory premarital examination requirement in China was cancelled in 2003, the rate of participation dropped sharply. This study examined the levels of exam satisfaction and the factors influencing satisfaction in the Hubei Province. METHODS: Graduate students administered 650 questionnaires, and 633 questionnaires were returned. Regression analysis was used to analyze satisfaction. RESULTS: The study found high levels of satisfaction, even though the exam participation rate was only 34.8%. A regression model for satisfaction showed that the most important objective factors were female sex (P < .05), specific city (P < .05), and level of education (P < .01); 2 important subjective variables were the level of understanding of the premarital examination (P < .01) and satisfaction with medical services of the premarital examination (P < .01). CONCLUSIONS: Satisfaction with the premarital examination might be increased by efforts to increase the level of understanding of the premarital examination and to improve medical services.
[Mh] Termos MeSH primário: Satisfação do Paciente
Exames Pré-Nupciais/psicologia
[Mh] Termos MeSH secundário: Adulto
China
Feminino
Seres Humanos
Masculino
Análise de Regressão
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1606
[Cu] Atualização por classe:161020
[Lr] Data última revisão:
161020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120414
[St] Status:MEDLINE
[do] DOI:10.1177/1010539512442954


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[PMID]:25150099
[Au] Autor:Shariq M; Moiz B; Zaidi N; Bin Azhar W; Iqbal W; Humaira A; Memon RN
[Ad] Endereço:Section of Haematology, Department of Pathology and Microbiology, Aga Khan University Hospital Karachi, Pakistan.
[Ti] Título:Pre-marital screening for beta thalassaemia in Pakistan: an insight.
[So] Source:J Med Screen;21(3):163-4, 2014 Sep.
[Is] ISSN:1475-5793
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Talassemia beta/diagnóstico
[Mh] Termos MeSH secundário: Feminino
Heterozigoto
Seres Humanos
Masculino
Programas de Rastreamento
Paquistão
Exames Pré-Nupciais
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1411
[Cu] Atualização por classe:140823
[Lr] Data última revisão:
140823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140824
[St] Status:MEDLINE
[do] DOI:10.1177/0969141314541434


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[PMID]:25030194
[Au] Autor:Canatan D
[Ad] Endereço:Mediterranean Blood Diseases Foundation , Antalya , Turkey.
[Ti] Título:Thalassemias and hemoglobinopathies in Turkey.
[So] Source:Hemoglobin;38(5):305-7, 2014.
[Is] ISSN:1532-432X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Thalassemias and hemoglobinopathies are a serious health problem in Turkey. There is a 70-year history of thalassemia in Turkey. The first patient with ß-thalassemia major (ß-TM) was reported in 1941. The first clinical and hematological studies were published by Aksoy in 1958. The overall incidence of ß-thalassemia (ß-thal) was reported by Çavdar and Arcasoy to be 2.1% in 1971. Important steps such as written regulations, education and prevention campaigns, have been taken to prevent thalassemia in Turkey by the Ministry of Health (MOH), the Turkish National Hemoglobinopathy Council (TNHC) and the Thalassemia Federation of Turkey (TFT) since 2000. A national hemoglobinopathy prevention program was started in provinces with a high prevalence by the MOH in 2003. While the percentage of premarital screening test was 30.0% of all couples in 2003, it reached 86.0% in 2013. While the number of newborn with thalassemias and hemoglobinopathies was 272 in 2002, it had dropped to 25 in 2010. There has been a 90.0% reduction of affected births in the last 10 years.
[Mh] Termos MeSH primário: Promoção da Saúde
Hemoglobinopatias/prevenção & controle
Talassemia/prevenção & controle
[Mh] Termos MeSH secundário: Informação de Saúde ao Consumidor
Aconselhamento Genético
Testes Genéticos
Educação em Saúde
Hemoglobinopatias/epidemiologia
Hemoglobinopatias/genética
Hemoglobinopatias/terapia
Seres Humanos
Incidência
Mutação
Exames Pré-Nupciais
Prevalência
Talassemia/epidemiologia
Talassemia/genética
Talassemia/terapia
Turquia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1506
[Cu] Atualização por classe:141002
[Lr] Data última revisão:
141002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140718
[St] Status:MEDLINE
[do] DOI:10.3109/03630269.2014.938163


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[PMID]:25030035
[Au] Autor:Abi Saad M; Haddad AG; Alam ES; Aoun S; Maatouk P; Ajami N; Khairallah T; Koussa S; Musallam KM; Taher AT
[Ad] Endereço:Chronic Care Center , Beirut , Lebanon.
[Ti] Título:Preventing thalassemia in Lebanon: successes and challenges in a developing country.
[So] Source:Hemoglobin;38(5):308-11, 2014.
[Is] ISSN:1532-432X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Thalassemia continues to be a major health burden. The chronicity of the disease and the high cost of life-long treatment make prevention strategies crucial in the management of this disease. In this article, we revisit different successful prevention strategies, and underline the Lebanese model. The Chronic Care Center (CCC), Beirut, is the only specialized center in Lebanon for the treatment and prevention of thalassemia. The current number of patients registered up to August 2013 was 724, representing cases from all over Lebanon. In 1994, the center launched a national prevention program following the World Health Organization (WHO) recommendations. The major activities of the program include awareness campaigns, screening for thalassemia carriers in the general population and high risk groups, registry of new cases and follow-up on the mandatory premarital law (established at the same time). Screening programs showed a carrier rate of around 2.3% in the general population, and 4.0-41.0% in high risk groups. The major pitfall in the law is that only persons with a mean corpuscular volume (MCV) of >70.0 fL are asked to perform further hemoglobin (Hb) testing. A significant decrease in the number of new cases of thalassemia patients in Lebanon reflects the efforts deployed in the prevention of the disease. However, some limitations are faced in reaching a complete eradication of the disease, mainly due to the fact that abortion is illegal and due to pitfalls and incorrect implementation of the premarital law.
[Mh] Termos MeSH primário: Promoção da Saúde
Talassemia/prevenção & controle
[Mh] Termos MeSH secundário: Informação de Saúde ao Consumidor
Países em Desenvolvimento
Triagem de Portadores Genéticos
Aconselhamento Genético
Testes Genéticos/legislação & jurisprudência
Promoção da Saúde/legislação & jurisprudência
Seres Humanos
Incidência
Líbano/epidemiologia
Mutação
Exames Pré-Nupciais
Sistema de Registros
Talassemia/epidemiologia
Talassemia/genética
Talassemia/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1506
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140718
[St] Status:MEDLINE
[do] DOI:10.3109/03630269.2014.939279



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