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[PMID]:29360867
[Au] Autor:Mücke D; Hermes A; Roettger TB; Becker J; Niemann H; Dembek TA; Timmermann L; Visser-Vandewalle V; Fink GR; Grice M; Barbe MT
[Ad] Endereço:IfL-Phonetics, University of Cologne, Cologne, Germany.
[Ti] Título:The effects of Thalamic Deep Brain Stimulation on speech dynamics in patients with Essential Tremor: An articulographic study.
[So] Source:PLoS One;13(1):e0191359, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Acoustic studies have revealed that patients with Essential Tremor treated with thalamic Deep Brain Stimulation (DBS) may suffer from speech deterioration in terms of imprecise oral articulation and reduced voicing control. Based on the acoustic signal one cannot infer, however, whether this deterioration is due to a general slowing down of the speech motor system (e.g., a target undershoot of a desired articulatory goal resulting from being too slow) or disturbed coordination (e.g., a target undershoot caused by problems with the relative phasing of articulatory movements). To elucidate this issue further, we here investigated both acoustics and articulatory patterns of the labial and lingual system using Electromagnetic Articulography (EMA) in twelve Essential Tremor patients treated with thalamic DBS and twelve age- and sex-matched controls. By comparing patients with activated (DBS-ON) and inactivated stimulation (DBS-OFF) with control speakers, we show that critical changes in speech dynamics occur on two levels: With inactivated stimulation (DBS-OFF), patients showed coordination problems of the labial and lingual system in terms of articulatory imprecision and slowness. These effects of articulatory discoordination worsened under activated stimulation, accompanied by an additional overall slowing down of the speech motor system. This leads to a poor performance of syllables on the acoustic surface, reflecting an aggravation either of pre-existing cerebellar deficits and/or the affection of the upper motor fibers of the internal capsule.
[Mh] Termos MeSH primário: Transtornos da Articulação/etiologia
Estimulação Encefálica Profunda/efeitos adversos
Tremor Essencial/terapia
Tálamo/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Transtornos da Articulação/fisiopatologia
Transtornos da Articulação/psicologia
Estudos de Casos e Controles
Tremor Essencial/fisiopatologia
Tremor Essencial/psicologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Fala/fisiologia
Acústica da Fala
Testes de Articulação da Fala
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180124
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191359


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[PMID]:28876369
[Au] Autor:Silva LMD; Vassoler AMO; Marino VCC; Berti LC
[Ad] Endereço:Universidade Estadual Paulista - UNESP - Marília (SP), Brasil.
[Ti] Título:Quantitative analysis of tongue movement in 14 phonemes of Brazilian Portuguese.
[Ti] Título:Análise ultrassonográfica quantitativa do movimento da língua em 14 fonemas do Português Brasileiro..
[So] Source:Codas;29(4):e20160211, 2017 Sep 04.
[Is] ISSN:2317-1782
[Cp] País de publicação:Brazil
[La] Idioma:por; eng
[Ab] Resumo:Purpose: The aim of this study was to characterize the ultrasonographic pattern of tongue movement in 14 consonant phonemes of Brazilian Portuguese (BP), seeking to identify and describe ultrasonographic parameters that could grasp the difference of manner and place of articulation among these phonemes. Methods: We selected 20 individuals with typical speech production, aged between 20-30 years of both genders. The selected stimuli included the 14 lingual consonant BP phonemes in the intervocalic context of [a]. Data were collected and analyzed with the use of ultrasound, and the AAA (Articulate Assistant Advanced) and the Ultra-CATS (The Ultrasonographic Contour Analyzer for Tongue Surfaces) softwares. Three ultrasound parameters were used for data analysis: anteriority index (AI), global average of tongue height (GA) and relative anteriority index (RAI). Data were statistically analyzed. Results: ANOVA showed a significant effect on the parameters and the RAI differentiated phonemes as the place (alveolar, pre-palatal, palatal and velar) and manner of articulation (fricative, nasal and occlusive); GA differentiate phonemes only as the place of articulation (alveolar, pre-palatal and velar). Conclusion: There was no single US parameter that could differentiate place and manner of articulation simultaneously. The clinical application for analysis of speech production disorders require the use of at least two ultrasound parameters: one to distinguish the place and another to distinguish the articulation manner.
[Mh] Termos MeSH primário: Fonética
Testes de Articulação da Fala/métodos
Língua/diagnóstico por imagem
Língua/fisiologia
[Mh] Termos MeSH secundário: Adulto
Brasil
Feminino
Seres Humanos
Linguagem
Masculino
Fala
Ultrassonografia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE


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[PMID]:28384803
[Au] Autor:Shriberg LD; Strand EA; Fourakis M; Jakielski KJ; Hall SD; Karlsson HB; Mabie HL; McSweeny JL; Tilkens CM; Wilson DL
[Ad] Endereço:Waisman Center, University of Wisconsin-Madison.
[Ti] Título:A Diagnostic Marker to Discriminate Childhood Apraxia of Speech From Speech Delay: II. Validity Studies of the Pause Marker.
[So] Source:J Speech Lang Hear Res;60(4):S1118-S1134, 2017 04 14.
[Is] ISSN:1558-9102
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: The purpose of this 2nd article in this supplement is to report validity support findings for the Pause Marker (PM), a proposed single-sign diagnostic marker of childhood apraxia of speech (CAS). Method: PM scores and additional perceptual and acoustic measures were obtained from 296 participants in cohorts with idiopathic and neurogenetic CAS, adult-onset apraxia of speech and primary progressive apraxia of speech, and idiopathic speech delay. Results: Adjusted for questionable specificity disagreements with a pediatric Mayo Clinic diagnostic standard, the estimated sensitivity and specificity, respectively, of the PM were 86.8% and 100% for the CAS cohort, yielding positive and negative likelihood ratios of 56.45 (95% confidence interval [CI]: [1.15, 2763.31]) and 0.13 (95% CI [0.06, 0.30]). Specificity of the PM for 4 cohorts totaling 205 participants with speech delay was 98.5%. Conclusion: These findings are interpreted as providing support for the PM as a near-conclusive diagnostic marker of CAS.
[Mh] Termos MeSH primário: Apraxias/diagnóstico
Transtornos do Desenvolvimento da Linguagem/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Idade de Início
Idoso
Idoso de 80 Anos ou mais
Apraxias/classificação
Apraxias/etiologia
Criança
Pré-Escolar
Estudos de Coortes
Diagnóstico Diferencial
Feminino
Seres Humanos
Transtornos do Desenvolvimento da Linguagem/classificação
Testes de Linguagem
Masculino
Meia-Idade
Sensibilidade e Especificidade
Acústica da Fala
Testes de Articulação da Fala
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.1044/2016_JSLHR-S-15-0297


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[PMID]:28384779
[Au] Autor:Shriberg LD; Strand EA; Fourakis M; Jakielski KJ; Hall SD; Karlsson HB; Mabie HL; McSweeny JL; Tilkens CM; Wilson DL
[Ad] Endereço:Waisman Center, University of Wisconsin-Madison.
[Ti] Título:A Diagnostic Marker to Discriminate Childhood Apraxia of Speech From Speech Delay: I. Development and Description of the Pause Marker.
[So] Source:J Speech Lang Hear Res;60(4):S1096-S1117, 2017 04 14.
[Is] ISSN:1558-9102
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: The goal of this article (PM I) is to describe the rationale for and development of the Pause Marker (PM), a single-sign diagnostic marker proposed to discriminate early or persistent childhood apraxia of speech from speech delay. Method: The authors describe and prioritize 7 criteria with which to evaluate the research and clinical utility of a diagnostic marker for childhood apraxia of speech, including evaluation of the present proposal. An overview is given of the Speech Disorders Classification System, including extensions completed in the same approximately 3-year period in which the PM was developed. Results: The finalized Speech Disorders Classification System includes a nosology and cross-classification procedures for childhood and persistent speech disorders and motor speech disorders (Shriberg, Strand, & Mabie, 2017). A PM is developed that provides procedural and scoring information, and citations to papers and technical reports that include audio exemplars of the PM and reference data used to standardize PM scores are provided. Conclusions: The PM described here is an acoustic-aided perceptual sign that quantifies one aspect of speech precision in the linguistic domain of phrasing. This diagnostic marker can be used to discriminate early or persistent childhood apraxia of speech from speech delay.
[Mh] Termos MeSH primário: Apraxias/diagnóstico
Transtornos do Desenvolvimento da Linguagem/diagnóstico
[Mh] Termos MeSH secundário: Apraxias/classificação
Criança
Diagnóstico Diferencial
Seres Humanos
Transtornos do Desenvolvimento da Linguagem/classificação
Linguística
Reprodutibilidade dos Testes
Acústica da Fala
Testes de Articulação da Fala
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.1044/2016_JSLHR-S-15-0296


  5 / 926 MEDLINE  
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[PMID]:28384751
[Au] Autor:Shriberg LD; Strand EA; Fourakis M; Jakielski KJ; Hall SD; Karlsson HB; Mabie HL; McSweeny JL; Tilkens CM; Wilson DL
[Ad] Endereço:Waisman Center, University of Wisconsin-Madison.
[Ti] Título:A Diagnostic Marker to Discriminate Childhood Apraxia of Speech From Speech Delay: III. Theoretical Coherence of the Pause Marker with Speech Processing Deficits in Childhood Apraxia of Speech.
[So] Source:J Speech Lang Hear Res;60(4):S1135-S1152, 2017 04 14.
[Is] ISSN:1558-9102
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: Previous articles in this supplement described rationale for and development of the pause marker (PM), a diagnostic marker of childhood apraxia of speech (CAS), and studies supporting its validity and reliability. The present article assesses the theoretical coherence of the PM with speech processing deficits in CAS. Method: PM and other scores were obtained for 264 participants in 6 groups: CAS in idiopathic, neurogenetic, and complex neurodevelopmental disorders; adult-onset apraxia of speech (AAS) consequent to stroke and primary progressive apraxia of speech; and idiopathic speech delay. Results: Participants with CAS and AAS had significantly lower scores than typically speaking reference participants and speech delay controls on measures posited to assess representational and transcoding processes. Representational deficits differed between CAS and AAS groups, with support for both underspecified linguistic representations and memory/access deficits in CAS, but for only the latter in AAS. CAS-AAS similarities in the age-sex standardized percentages of occurrence of the most frequent type of inappropriate pauses (abrupt) and significant differences in the standardized occurrence of appropriate pauses were consistent with speech processing findings. Conclusions: Results support the hypotheses of core representational and transcoding speech processing deficits in CAS and theoretical coherence of the PM's pause-speech elements with these deficits.
[Mh] Termos MeSH primário: Apraxias/diagnóstico
Transtornos do Desenvolvimento da Linguagem/diagnóstico
Modelos Teóricos
Percepção da Fala
Fala
[Mh] Termos MeSH secundário: Adolescente
Idoso
Idoso de 80 Anos ou mais
Apraxias/etiologia
Criança
Pré-Escolar
Diagnóstico Diferencial
Feminino
Seres Humanos
Testes de Linguagem
Masculino
Meia-Idade
Testes de Articulação da Fala
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.1044/2016_JSLHR-S-15-0298


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[PMID]:28222332
[Au] Autor:Oohashi H; Watanabe H; Taga G
[Ad] Endereço:Graduate School of Education, The University of Tokyo, Bunkyo-ku 7-3-1, 113-0033 Tokyo, Japan. Electronic address: hiro084@gmail.com.
[Ti] Título:Acquisition of vowel articulation in childhood investigated by acoustic-to-articulatory inversion.
[So] Source:Infant Behav Dev;46:178-193, 2017 02.
[Is] ISSN:1934-8800
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:While the acoustical features of speech sounds in children have been extensively studied, limited information is available as to their articulation during speech production. Instead of directly measuring articulatory movements, this study used an acoustic-to-articulatory inversion model with scalable vocal tract size to estimate developmental changes in articulatory state during vowel production. Using a pseudo-inverse Jacobian matrix of a model mapping seven articulatory parameters to acoustic ones, the formant frequencies of each vowel produced by three Japanese children over time at ages between 6 and 60 months were transformed into articulatory parameters. We conducted the discriminant analysis to reveal differences in articulatory states for production of each vowel. The analysis suggested that development of vowel production went through gradual functionalization of articulatory parameters. At 6-9 months, the coordination of position of tongue body and lip aperture forms three vowels: front, back, and central. At 10-17 months, recruitments of jaw and tongue apex enable differentiation of these three vowels into five. At 18 months and older, recruitment of tongue shape produces more distinct vowels specific to Japanese. These results suggest that the jaw and tongue apex contributed to speech production by young children regardless of kinds of vowel. Moreover, initial articulatory states for each vowel could be distinguished by the manner of coordination between lip and tongue, and these initial states are differentiated and refined into articulations adjusted to the native language over the course of development.
[Mh] Termos MeSH primário: Desenvolvimento da Linguagem
Fonética
Acústica da Fala
Testes de Articulação da Fala/métodos
[Mh] Termos MeSH secundário: Pré-Escolar
Feminino
Seres Humanos
Lactente
Linguagem
Masculino
Fala/fisiologia
Testes de Articulação da Fala/tendências
Percepção da Fala/fisiologia
Língua/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171119
[Lr] Data última revisão:
171119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170222
[St] Status:MEDLINE


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[PMID]:28207800
[Au] Autor:McAllister Byun T; Tiede M
[Ad] Endereço:Department of Communicative Sciences and Disorders, New York University, New York, New York, United States of America.
[Ti] Título:Perception-production relations in later development of American English rhotics.
[So] Source:PLoS One;12(2):e0172022, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:It is known that some adult listeners have more sharply defined perceptual categories than others, and listeners with more precise auditory targets are also more precise in their production of contrasts. There is additionally evidence that children who have not yet mastered production of a contrast show diminished performance on perceptual measures of the same contrast. To date, however, few studies have investigated developmental perception-production relations using the fine-grained measures typical of adult studies. Existing evidence suggests that perception and production can be closely connected in development, but this relationship may break down as perception and articulation mature at different rates. This study evaluated perception and production of the English /r-w/ contrast in 40 typically-developing children aged 9-14. Perceptual sensitivity was measured with a logistic function fitted over responses in a forced-choice identification task using two synthetic 10-step continua from rake to wake. Participants also produced rhotic and non-rhotic words. Across participants, there was a significant correlation between perceptual acuity and rhoticity in production, although this effect was only observed for one of two continua tested. These results provide preliminary evidence compatible with the hypothesis that children with a more refined auditory target for a sound also produce that sound more accurately.
[Mh] Termos MeSH primário: Percepção Auditiva/fisiologia
Linguagem
Fonética
Testes de Articulação da Fala
Percepção da Fala/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Criança
Feminino
Seres Humanos
Masculino
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170217
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0172022


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[PMID]:28127863
[Au] Autor:Persson C; Laakso K; Edwardsson H; Lindblom J; Hartelius L
[Ad] Endereço:Institute of Neuroscience and Physiology, Speech and Language Pathology Unit, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
[Ti] Título:Signs of dysarthria in adults with 22q11.2 deletion syndrome.
[So] Source:Am J Med Genet A;173(3):618-626, 2017 Mar.
[Is] ISSN:1552-4833
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of the study was to investigate how adults with 22q11.2 deletion syndrome (22q11DS) performed on dysarthria and intelligibility tests compared with a control group. Ten participants with confirmed 22q11.2 deletion, five males and five females with a mean age of 31 years (range: 19-49), were compared with a control group matched for gender and age (five males and five females, mean age: 32 years, range: 19-49). Assessment of non-verbal and verbal tasks reflecting respiration, phonation, oral motor function, velopharyngeal function, articulation, and prosody was performed as well as the Swedish Test of Intelligibility (STI). All assessments were made by two raters; inter-rater and intra-rater reliability was acceptable. The participants with 22q11DS had significantly more problems than the control group on all investigated dimensions except the STI. Overall, the severity of their speech deviation was rated as mild to moderate. The largest difficulties were found regarding speech respiration, phonation, oral motor function, and velopharyngeal function. The results of the present study suggest that a neurological etiology could be added to the previously described structural etiology explaining the speech difficulties found in 22q11DS. Signs of difficulties in both speech motor planning and speech motor programming were found. Further studies are needed to confirm the results, as are studies of the association between structural brain abnormalities and neurological speech symptoms. For clinical purposes, it is important that clinicians have knowledge about the variable speech symptoms that may occur in individuals with 22q11DS and that they be aware of the complexity of the etiology of such speech symptoms. © 2017 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Síndrome de DiGeorge/diagnóstico
Síndrome de DiGeorge/genética
Disartria/diagnóstico
Disartria/genética
Estudos de Associação Genética
Fenótipo
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Feminino
Seres Humanos
Hibridização in Situ Fluorescente
Testes de Inteligência
Masculino
Meia-Idade
Reprodutibilidade dos Testes
Testes de Articulação da Fala
Comportamento Verbal
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170128
[St] Status:MEDLINE
[do] DOI:10.1002/ajmg.a.38038


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[PMID]:28103278
[Au] Autor:Vainio L; Rantala A; Tiainen M; Tiippana K; Komeilipoor N; Vainio M
[Ad] Endereço:Institute of Behavioural Sciences, Division of Cognitive and Neuropsychology, University of Helsinki, Helsinki, Finland.
[Ti] Título:Systematic Influence of Perceived Grasp Shape on Speech Production.
[So] Source:PLoS One;12(1):e0170221, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Previous research has shown that precision and power grip performance is consistently influenced by simultaneous articulation. For example, power grip responses are performed relatively fast with the open-back vowel [a], whereas precision grip responses are performed relatively fast with the close-front vowel [i]. In the present study, the participants were presented with a picture of a hand shaped to the precision or power grip. They were required to pronounce speech sounds according to the front/above perspective of the hand. The results showed that not only the grip performance is affected by simultaneously pronouncing the speech sound but also the production of speech sound can be affected by viewing an image of a grip. The precision grip stimulus triggered relatively rapid production of the front-close vowel [i]. In contrast, the effect related to the power grip stimulus was mostly linked to the vertical dimension of the pronounced vowel since this stimulus triggered relatively rapid production of the back-open vowel [a] and back-mid-open vowel [o] while production of the back-close vowel [u] was not influenced by it. The fact that production of the dorsal consonant [k] or coronal consonant [t] were not influenced by these stimuli suggests that the effect was not associated with a relative front-back tongue shape of the articulation in the absence of changes in any vertical articulatory components. These findings provide evidence for an intimate interaction between certain articulatory gestures and grip types, suggesting that an overlapping visuomotor network operates for planning articulatory gestures and grasp actions.
[Mh] Termos MeSH primário: Força da Mão/fisiologia
Fala/fisiologia
[Mh] Termos MeSH secundário: Estimulação Acústica
Adulto
Feminino
Gestos
Mãos
Seres Humanos
Masculino
Fonética
Estimulação Luminosa
Desempenho Psicomotor/fisiologia
Tempo de Reação/fisiologia
Testes de Articulação da Fala
Percepção da Fala/fisiologia
Medida da Produção da Fala
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170120
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0170221


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[PMID]:27491321
[Au] Autor:Wolf AE; Mourão L; França MC; Machado Júnior AJ; Crespo AN
[Ad] Endereço:School of Medicine Ribeirão Preto, USP Ribeirão Preto, Ribeirão Preto, Brazil.
[Ti] Título:Phonoarticulation in spinocerebellar ataxia type 3.
[So] Source:Eur Arch Otorhinolaryngol;274(2):1139-1145, 2017 02.
[Is] ISSN:1434-4726
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Phonoarticulation is characterized by changes in resonance, diadochokinesis, prosody, sound frequency, vocal quality, and intraoral pressure. The main aim of this study was to characterize the phonoarticulation in spinocerebellar ataxia type 3 (SCA3) and correlate it with clinical and genetic factors. Thirty-one patients with SCA3 who were subjected to spontaneous speech recordings and phonoarticulatory diadochokinesis (DDK) participated in the study. Speech analyses were performed starting after 10 s of spontaneous speech, by three experienced speech therapists, using a protocol for dysarthria adapted from the Mayo Clinic. The intra-evaluator reliability was analyzed. The lower the patient's age at disease onset was, the more frequent the occurrences of monofrequency and altered speech rhythm were. Articulation, DDK, resonance, and prosody showed a moderate correlation with the number of "CAG" triplet repeats. We conclude that the phonoarticulation of patients with Machado-Joseph disease (MJD) is characterized by mixed dysarthrophonia with cerebellar and hypokinetic components, and that there is a tendency toward higher frequency of dysarthrophonia symptoms with lower age of disease onset, longer time since onset and higher number of "CAG" triplet repeats.
[Mh] Termos MeSH primário: Disartria/etiologia
Doença de Machado-Joseph/complicações
Transtorno Fonológico/etiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idade de Início
Idoso
Disartria/diagnóstico
Disartria/genética
Feminino
Seres Humanos
Doença de Machado-Joseph/genética
Masculino
Meia-Idade
Variações Dependentes do Observador
Reprodutibilidade dos Testes
Testes de Articulação da Fala
Transtorno Fonológico/diagnóstico
Transtorno Fonológico/genética
Repetições de Trinucleotídeos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160806
[St] Status:MEDLINE
[do] DOI:10.1007/s00405-016-4240-x



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