Base de dados : MEDLINE
Pesquisa : E01.894 [Categoria DeCS]
Referências encontradas : 557 [refinar]
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[PMID]:29231930
[Au] Autor:Jing Y; Cao Q; Hao L; Yang GG; Hu WL; Ji LN; Mao ZW
[Ad] Endereço:MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China. cesmzw@mail.sysu.edu.cn caoqian3@mail.sysu.edu.cn.
[Ti] Título:A self-assessed photosensitizer: inducing and dual-modal phosphorescence imaging of mitochondria oxidative stress.
[So] Source:Chem Commun (Camb);54(3):271-274, 2018 Jan 02.
[Is] ISSN:1364-548X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two novel Ir(iii)-nitroxide conjugates have been synthesized as mitochondria-targeted multi-functional theranostic photosensitizers, capable of simultaneously inducing and dual-modal phosphorescence imaging of mitochondrial oxidative stress under two-photon excitation, thus realizing the photodynamic therapy of cancer and self-assessment of their PDT efficacies.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Complexos de Coordenação/farmacologia
Óxidos N-Cíclicos/farmacologia
Irídio/química
Substâncias Luminescentes/farmacologia
Mitocôndrias/metabolismo
Estresse Oxidativo
Fármacos Fotossensibilizantes/farmacologia
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/química
Apoptose/efeitos dos fármacos
Linhagem Celular Tumoral
Complexos de Coordenação/química
Óxidos N-Cíclicos/química
Seres Humanos
Peróxido de Hidrogênio/farmacologia
Luz
Substâncias Luminescentes/química
Mitocôndrias/ultraestrutura
Fármacos Fotossensibilizantes/química
Acetato de Tetradecanoilforbol/farmacologia
Nanomedicina Teranóstica
Peixe-Zebra
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Coordination Complexes); 0 (Cyclic N-Oxides); 0 (Luminescent Agents); 0 (Photosensitizing Agents); 44448S9773 (Iridium); BBX060AN9V (Hydrogen Peroxide); NI40JAQ945 (Tetradecanoylphorbol Acetate)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.1039/c7cc07797a


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[PMID]:29384618
[Au] Autor:Pitchaimani A; Duong T; Nguyen T; Maurmann L; Key J; Bossmann SH; Aryal S
[Ti] Título:Gd³âº Tethered Gold Nanorods for Combined Magnetic Resonance Imaging and Photo-Thermal Therapy.
[So] Source:J Biomed Nanotechnol;13(4):417-26, 2017 Apr.
[Is] ISSN:1550-7033
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Near infrared (NIR) mediated photothermal therapy and magnetic resonance imaging (MRI) are promising treatment and imaging modalities in the field of cancer theranostics. Gold nanorods are the first choice of materials for NIR-mediated photothermal therapy due to their strong localized surface plasmon resonance (LSPR) at NIR region. Similarly, gadolinium based MRI contrast agents have an ability to increase the ionic and molecular relaxivity, thereby enhancing the solvent proton relaxation rate resulting in contrast enhancement. Herein, the effort has been made to engineer a dual front theranostic agent with combined photothermal and magnetic resonance imaging capacity using gadolinium tethered gold nanorods (Gd3+-AuNR). NIR-responsive gold nanorods were surface fabricated by means of Au-thiol interaction using a thiolated macrocyclic chelator that chelates Gd3+ ions, and further stabilized by thiolated polyethylene glycol (PEG-SH). The magnetic properties of the Gd3+-AuNR displayed an enhanced r 1 relaxivity of 12.1 mM­1s­1, with higher biological stability, and contrast enhancement in both solution state and in cell pellets. In-vitro (cell-free) and ex-vivo (on pig skin) analysis of the Gd3+-AuNR shows enhanced photothermal properties as equivalent to that of the raw AuNR. Furthermore, Gd3+-AuNR showed competent cellular entry and intracellular distribution as revealed by hyperspectral microscopy. In addition, Gd3+-AuNR also exhibits significant thermal ablation of B16­F10 cells in the presence of NIR. Thus, Gd3+-AuNR features a significant theranostic potential with combined photothermal and imaging modality, suggesting a great potential in anticancer therapy.
[Mh] Termos MeSH primário: Gadolínio/química
Ouro/uso terapêutico
Imagem por Ressonância Magnética/métodos
Nanopartículas Metálicas/uso terapêutico
Fotoquimioterapia/métodos
Neoplasias Cutâneas/diagnóstico por imagem
Neoplasias Cutâneas/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Meios de Contraste/química
Ouro/química
Nanopartículas Metálicas/química
Nanopartículas Metálicas/ultraestrutura
Camundongos
Nanocápsulas/administração & dosagem
Nanocápsulas/química
Nanocápsulas/ultraestrutura
Nanotubos/química
Fármacos Fotossensibilizantes/uso terapêutico
Neoplasias Cutâneas/patologia
Nanomedicina Teranóstica/métodos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Contrast Media); 0 (Nanocapsules); 0 (Photosensitizing Agents); 7440-57-5 (Gold); AU0V1LM3JT (Gadolinium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE


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[PMID]:27776285
[Au] Autor:Gao S; Wang G; Qin Z; Wang X; Zhao G; Ma Q; Zhu L
[Ad] Endereço:Department of Nuclear Medicine, China-Japan Union Hospital, Jilin University, Changchun, Jilin, 130033, China.
[Ti] Título:Oxygen-generating hybrid nanoparticles to enhance fluorescent/photoacoustic/ultrasound imaging guided tumor photodynamic therapy.
[So] Source:Biomaterials;112:324-335, 2017 01.
[Is] ISSN:1878-5905
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Photodynamic therapy (PDT) is a promising tumor treatment modality that can convert oxygen into cytotoxic singlet oxygen (SO) via photosensitizer to ablate tumor growth. However, the uncontrolled cancer cell proliferation during tumor development and the oxygen consumption during PDT always result in an insufficient oxygen level in tumors, which can adversely affect the PDT efficiency in turn. We designed an oxygen-generating PDT nanocomplex by encapsulating a manganese dioxide nanoparticle (MnO NP) in an indocyanine green (ICG) modified hyaluronic acid nanoparticle (HANP) to overcome this limitation. Because of the excellent fluorescent and photoacoustic properties, the tumor accumulation of the ICG-HANP/MnO (IHM) nanocomplex was monitored by fluorescent imaging and photoacoustic imaging after intravenous administration into the SCC7 tumor-bearing mouse model. Both high fluorescent and photoacoustic signals were detected and found peak at 6 h post-injection (tumor-muscle ratio: 4.03 ± 0.36 for fluorescent imaging and 2.93 ± 0.13 for photoacoustic imaging). In addition, due to the high reactivity of MnO NP to H O , an unfavorable tumor cell metabolic, the oxygen content in the tumor is elevated 2.25 ± 0.07 times compared to that without IHM treatment as ultrasound imaging confirmed. After laser irradiation, significant tumor growth inhibition was observed in the IHM-treated group compared to the ICG-HANP-treated group, attributed to the beneficial oxygen-generating property of IHM for PDT. It is expected that the design of IHM will provide an alternative way of improving clinical PDT efficacy and will be widely applied in cancer theranostics.
[Mh] Termos MeSH primário: Microscopia de Fluorescência/métodos
Nanocápsulas/administração & dosagem
Neoplasias Experimentais/diagnóstico por imagem
Neoplasias Experimentais/tratamento farmacológico
Oxigênio/administração & dosagem
Fotoquimioterapia/métodos
Ultrassonografia/métodos
[Mh] Termos MeSH secundário: Animais
Feminino
Camundongos
Camundongos Nus
Nanocápsulas/química
Nanocápsulas/ultraestrutura
Nanoconjugados/administração & dosagem
Nanoconjugados/química
Nanoconjugados/ultraestrutura
Oxigênio/química
Técnicas Fotoacústicas/métodos
Fármacos Fotossensibilizantes/administração & dosagem
Fármacos Fotossensibilizantes/química
Nanomedicina Teranóstica/métodos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Nanocapsules); 0 (Nanoconjugates); 0 (Photosensitizing Agents); S88TT14065 (Oxygen)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180106
[Lr] Data última revisão:
180106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:29045226
[Au] Autor:Adam LC; Murali N; Chapiro J; Geschwind JF
[Ad] Endereço:Department of Radiology and Biomedical Imaging Yale University School of Medicine 300 Cedar St New Haven, CT 06520.
[Ti] Título:Science to Practice: Molecular-targeted Drug Delivery in Combination with Radiofrequency Ablation of Liver Cancer: A Magic Bullet?
[So] Source:Radiology;285(2):333-335, 2017 Nov.
[Is] ISSN:1527-1315
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In an effort to improve the technical success rates and clinical outcomes of radiofrequency (RF) ablation, Yan et al validated the use of a tumor-penetrating peptide and thermosensitive doxorubicin (DOX)-loaded nanoparticles in combination with RF ablation in a hepatocellular carcinoma mouse model. By achieving higher chemotherapeutic drug concentrations in target lesions, fewer toxic effects, and improved survival end points in an animal tumor model, the authors conclude that superior tumor treatment with RF ablation is possible when combined with molecular-targeted drug delivery systems.
[Mh] Termos MeSH primário: Antineoplásicos
Ablação por Cateter/métodos
Portadores de Fármacos
Neoplasias Hepáticas Experimentais
Imagem Molecular/métodos
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/química
Antineoplásicos/uso terapêutico
Doxorrubicina/química
Doxorrubicina/uso terapêutico
Portadores de Fármacos/química
Portadores de Fármacos/uso terapêutico
Neoplasias Hepáticas Experimentais/diagnóstico por imagem
Neoplasias Hepáticas Experimentais/tratamento farmacológico
Camundongos
Nanopartículas/química
Nanopartículas/uso terapêutico
Peptídeos/química
Peptídeos/uso terapêutico
Nanomedicina Teranóstica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Drug Carriers); 0 (Peptides); 80168379AG (Doxorubicin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171121
[Lr] Data última revisão:
171121
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171019
[St] Status:MEDLINE
[do] DOI:10.1148/radiol.2017171527


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[PMID]:28994330
[Au] Autor:Yang W; Ma J; Zhou W; Cao B; Zhou X; Yang Z; Zhang H; Zhao Q; Fan D; Hong L
[Ad] Endereço:a State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases , Fourth Military Medical University , Xi'an , China.
[Ti] Título:Molecular mechanisms and theranostic potential of miRNAs in drug resistance of gastric cancer.
[So] Source:Expert Opin Ther Targets;21(11):1063-1075, 2017 Nov.
[Is] ISSN:1744-7631
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Systemic chemotherapy is a curative approach to inhibit gastric cancer cells proliferation. Despite the great progress in anti-cancer treatment achieved during the last decades, drug resistance and treatment refractoriness still extensively persists. Recently, accumulating studies have highlighted the role of miRNAs in drug resistance of gastric cancers by modulating some drug resistance-related proteins and genes expression. Pre-clinical reports indicate that miRNAs might serve as ideal biomarkers and potential targets, thus holding great promise for developing targeted therapy and personalized treatment for the patients with gastric cancer. Areas covered: This review provide a comprehensive overview of the current advances of miRNAs and molecular mechanisms underlying miRNA-mediated drug resistance in gastric cancer. We particularly focus on the potential values of drug resistance-related miRNAs as biomarkers and novel targets in gastric cancer therapy and envisage the future research developments of these miRNAs and challenges in translating the new findings into clinical applications. Expert opinion: Although the concrete mechanisms of miRNAs in drug resistance of gastric cancer have not been fully clarified, miRNA may be a promising theranostic approach. Further studies are still needed to facilitate the clinical applications of miRNAs in drug resistant gastric cancer.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
MicroRNAs/genética
Neoplasias Gástricas/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Desenho de Drogas
Resistência a Medicamentos Antineoplásicos
Regulação Neoplásica da Expressão Gênica
Seres Humanos
Terapia de Alvo Molecular
Neoplasias Gástricas/genética
Neoplasias Gástricas/patologia
Nanomedicina Teranóstica/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (MicroRNAs)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171011
[St] Status:MEDLINE
[do] DOI:10.1080/14728222.2017.1389900


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[PMID]:28800509
[Au] Autor:Nagesetti A; Srinivasan S; McGoron AJ
[Ad] Endereço:Biomedical Engineering Department, 10555 West Flagler Street, EC 2614, Florida International University, Miami, FL 33174, USA.
[Ti] Título:Polyethylene glycol modified ORMOSIL theranostic nanoparticles for triggered doxorubicin release and deep drug delivery into ovarian cancer spheroids.
[So] Source:J Photochem Photobiol B;174:209-216, 2017 Sep.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:A novel pegylated multifunctional probe of Ormosil nanoparticles (PEGCDSIR820) loaded with Near Infrared dye (NIR; IR820) and a chemotherapeutic drug, Doxorubicin (DOX) was developed for cancer theranostic applications. PEGCDSIR820 nanoparticles had an average diameter of 58.2±3.1nm, zeta potential of -6.9±0.1mV in cell culture media and stability against aggregation in physiological buffers. The encapsulation efficiency of DOX was 65.0±3.0%, and that of IR820 was 76.0±2.1%. PEGCDSIR820 showed no cytotoxicity in ovarian cancer cells (Skov-3). The cytotoxicity markedly increased when Skov-3 cells incubated with PEGCDSIR820 particles were exposed to 808nm laser due to the combination of adjuvant hyperthermia (43°C) and enhanced DOX release. Exposure to laser enhanced the release of DOX, 45% of DOX release was observed in 3h compared to 23% without laser exposure. Confocal imaging in Skov-3 cells showed that the combination of hyperthermia due to NIR exposure and release of DOX caused cell necrosis. Furthermore, in spheroids exposed to NIR laser penetration of DOX was deeper compared to the absence of laser exposure. Skov-3 spheroids incubated with pegylated nanoparticles for 24h and exposed to laser showed 94% reduction in cell viability. Encapsulation of IR820 in PEGCDSIR820 increased the in-vivo elimination half-life to 41.0±7.2h from 30.5±0.5h of free IR820.
[Mh] Termos MeSH primário: Doxorrubicina/química
Liberação Controlada de Fármacos
Nanopartículas/química
Neoplasias Ovarianas/patologia
Polietilenoglicóis/química
Siloxanas/química
Esferoides Celulares/metabolismo
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Doxorrubicina/metabolismo
Doxorrubicina/farmacologia
Portadores de Fármacos/química
Portadores de Fármacos/farmacocinética
Feminino
Seres Humanos
Cinética
Tamanho da Partícula
Temperatura Ambiente
Nanomedicina Teranóstica
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drug Carriers); 0 (Siloxanes); 0 (ormosil); 30IQX730WE (Polyethylene Glycols); 80168379AG (Doxorubicin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170812
[St] Status:MEDLINE


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[PMID]:28794626
[Au] Autor:Luo X; Peng X; Hou J; Wu S; Shen J; Wang L
[Ad] Endereço:Department of Gastroenterology.
[Ti] Título:Folic acid-functionalized polyethylenimine superparamagnetic iron oxide nanoparticles as theranostic agents for magnetic resonance imaging and PD-L1 siRNA delivery for gastric cancer.
[So] Source:Int J Nanomedicine;12:5331-5343, 2017.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Programmed death ligand-1 (PD-L1), which is highly expressed in gastric cancers, interacts with programmed death-1 (PD-1) on T cells and is involved in T-cell immune resistance. To increase the therapeutic safety and accuracy of PD-1/PD-L1 blockade, RNA interference through targeted gene delivery was performed in our study. We developed folic acid (FA)- and disulfide (SS)-polyethylene glycol (PEG)-conjugated polyethylenimine (PEI) complexed with superparamagnetic iron oxide Fe O nanoparticles (SPIONs) as a siRNA-delivery system for PD-L1 knockdown. The characterization, binding ability, cytotoxicity, transfection efficiency, and cellular internalization of the polyplex were determined. At nitrogen:phosphate (N:P) ratios of 10 or above, the FA-PEG-SS-PEI-SPIONs bound to PD-L1 siRNA to form a polyplex with a diameter of approximately 120 nm. Cell-viability assays showed that the polyplex had minimal cytotoxicity at low N:P ratios. The FA-conjugated polyplex showed higher transfection efficiency and cellular internalization in the folate receptor-overexpressing gastric cancer cell line SGC-7901 than a non-FA-conjugated polyplex. Subsequently, we adopted the targeted FA-PEG-SS-PEI-SPION/siRNA polyplexes at an N:P ratio of 10 for function studies. Cellular magnetic resonance imaging (MRI) showed that the polyplex could also act as a -weighted contrast agent for cancer MRI. Furthermore, one of four PD-L1 siRNAs exhibited effective PD-L1 knockdown in PD-L1-overexpressing SGC-7901. To determine the effects of the functionalized polyplex on T-cell function, we established a coculture model of activated T cells and SGC-7901 cells and demonstrated changes in secreted cytokines. Our findings highlight the potential of this class of multifunctional theranostic nanoparticles for effective targeted PD-L1-knockdown therapy and MRI diagnosis in gastric cancers.
[Mh] Termos MeSH primário: Antígeno B7-H1/genética
Imagem por Ressonância Magnética/métodos
Nanopartículas de Magnetita/química
RNA Interferente Pequeno/administração & dosagem
Nanomedicina Teranóstica/métodos
[Mh] Termos MeSH secundário: Sobrevivência Celular/efeitos dos fármacos
Técnicas de Cocultura
Meios de Contraste/química
Compostos Férricos/química
Ácido Fólico/química
Técnicas de Transferência de Genes
Seres Humanos
Nanopartículas de Magnetita/administração & dosagem
Polietilenoglicóis/química
Polietilenoimina/química
RNA Interferente Pequeno/genética
Neoplasias Gástricas/diagnóstico por imagem
Neoplasias Gástricas/tratamento farmacológico
Neoplasias Gástricas/terapia
Succinimidas/química
Transfecção
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (B7-H1 Antigen); 0 (CD274 protein, human); 0 (Contrast Media); 0 (Ferric Compounds); 0 (Magnetite Nanoparticles); 0 (RNA, Small Interfering); 0 (Succinimides); 1K09F3G675 (ferric oxide); 30IQX730WE (Polyethylene Glycols); 85419-94-9 (polyethylene glycol bis(succinimidyl succinate)); 9002-98-6 (Polyethyleneimine); 935E97BOY8 (Folic Acid)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170811
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S137245


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[PMID]:28750318
[Au] Autor:Macharia DK; Tian Q; Chen L; Sun Y; Yu N; He C; Wang H; Chen Z
[Ad] Endereço:State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China.
[Ti] Título:PEGylated (NH ) WO nanorods as efficient and stable multifunctional nanoagents for simultaneous CT imaging and photothermal therapy of tumor.
[So] Source:J Photochem Photobiol B;174:10-17, 2017 Sep.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The simultaneous imaging and photothermal therapy of tumors have attracted much attention, and a prerequisite is to obtain multifunctional nanomaterials. Ideally, one kind of nanoparticles with single component can be used as both imaging agent and photothermal agent. Herein, we have developed the PEGylated (NH ) WO (denoted as (NH ) WO -PEG) nanorods as multifunctional nanoparticles with single semiconductor component. (NH ) WO -PEG nanorods with about 30nm diameter and length of several hundred nanometers have been obtained through a solvothermal synthesis-PEGylation two-step route. Under the irradiation of 980-nm laser with intensity of 0.72Wcm , aqueous dispersion of (NH ) WO -PEG nanorods (0.67-5.44mmol/L) displays high elevation (17.6-34.5°C) of temperature in 400s, accompanied by an excellent long-term photothermal stability. Furthermore, (NH ) WO -PEG nanorods exhibit as high as 6 times X-ray attenuation ability compared to that of the clinically used iodine-based X-ray computed tomography (CT) contrast agent (Iopromide). More importantly, after PBS solution of (NH ) WO -PEG nanorods is injected into the tumor of mice, the tumor can be effectively detected by CT imaging. Moreover, cancer cells in vivo can be further destroyed by the photothermal effects of (NH ) WO -PEG nanorods, under the irradiation of 980-nm laser with the safe intensity of 0.72Wcm for 10min. Therefore, (NH ) WO -PEG nanorods can be used as a new kind of stable and efficient multifunctional nanoagent with single component for simultaneous CT imaging and photothermal therapy of tumor.
[Mh] Termos MeSH primário: Adenocarcinoma/diagnóstico por imagem
Adenocarcinoma/terapia
Neoplasias Pulmonares/diagnóstico por imagem
Neoplasias Pulmonares/terapia
Nanotubos
Óxidos/uso terapêutico
Fototerapia/métodos
Polietilenoglicóis/química
Tomografia Computadorizada por Raios X/métodos
Tungstênio/uso terapêutico
[Mh] Termos MeSH secundário: Adenocarcinoma/patologia
Animais
Transformação Celular Neoplásica
Estabilidade de Medicamentos
Células HeLa
Seres Humanos
Neoplasias Pulmonares/patologia
Camundongos
Camundongos Nus
Óxidos/química
Nanomedicina Teranóstica
Tungstênio/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oxides); 30IQX730WE (Polyethylene Glycols); 940E10M08M (tungsten oxide); V9306CXO6G (Tungsten)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE


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[PMID]:28670120
[Au] Autor:Wu B; Wan B; Lu ST; Deng K; Li XQ; Wu BL; Li YS; Liao RF; Huang SW; Xu HB
[Ad] Endereço:Department of Radiology, Zhongnan Hospital of Wuhan University.
[Ti] Título:Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy.
[So] Source:Int J Nanomedicine;12:4467-4478, 2017.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:The major challenge in current clinic contrast agents (CAs) and chemotherapy is the poor tumor selectivity and response. Based on the self-quench property of IR820 at high concentrations, and different contrast effect ability of Gd-DOTA between inner and outer of liposome, we developed "bomb-like" light-triggered CAs (LTCAs) for enhanced CT/MRI/FI multimodal imaging, which can improve the signal-to-noise ratio of tumor tissue specifically. IR820, Iohexol and Gd-chelates were firstly encapsulated into the thermal-sensitive nanocarrier with a high concentration. This will result in protection and fluorescence quenching. Then, the release of CAs was triggered by near-infrared (NIR) light laser irradiation, which will lead to fluorescence and MRI activation and enable imaging of inflammation. In vitro and in vivo experiments demonstrated that LTCAs with 808 nm laser irradiation have shorter T relaxation time in MRI and stronger intensity in FI compared to those without irradiation. Additionally, due to the high photothermal conversion efficiency of IR820, the injection of LTCAs was demonstrated to completely inhibit C6 tumor growth in nude mice up to 17 days after NIR laser irradiation. The results indicate that the LTCAs can serve as a promising platform for NIR-activated multimodal imaging and photothermal therapy.
[Mh] Termos MeSH primário: Meios de Contraste/química
Imagem Multimodal/métodos
Neoplasias Experimentais/diagnóstico por imagem
[Mh] Termos MeSH secundário: Animais
Feminino
Compostos Heterocíclicos/química
Seres Humanos
Verde de Indocianina/análogos & derivados
Verde de Indocianina/química
Raios Infravermelhos
Lipossomos/química
Imagem por Ressonância Magnética/métodos
Camundongos Endogâmicos BALB C
Camundongos Nus
Imagem Multimodal/instrumentação
Neoplasias/patologia
Neoplasias Experimentais/terapia
Compostos Organometálicos/química
Fototerapia/métodos
Razão Sinal-Ruído
Nanomedicina Teranóstica/instrumentação
Nanomedicina Teranóstica/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 0 (Heterocyclic Compounds); 0 (IR 820); 0 (Liposomes); 0 (Organometallic Compounds); 99J2XUF1JT (gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate); IX6J1063HV (Indocyanine Green)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170704
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S137835


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[PMID]:28668475
[Au] Autor:Gharatape A; Salehi R
[Ad] Endereço:Department of Medical Nanotechnology, School of Advanced Medical Science, Tabriz University of Medical Science, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
[Ti] Título:Recent progress in theranostic applications of hybrid gold nanoparticles.
[So] Source:Eur J Med Chem;138:221-233, 2017 Sep 29.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:A significant area of research is theranostic applications of nanoparticles, which involves efforts to improve delivery and reduce side effects. Accordingly, the introduction of a safe, effective, and, most importantly, renewable strategy to target, deliver and image disease cells is important. This state-of-the-art review focuses on studies done from 2013 to 2016 regarding the development of hybrid gold nanoparticles as theranostic agents in the diagnosis and treatment of cancer and infectious disease. Several syntheses (chemical and green) methods of gold nanoparticles and their applications in imaging, targeting, and delivery are reviewed; their photothermal efficiency is discussed as is the toxicity of gold nanoparticles. Owing to the unique characterizations of hybrid gold nanoparticles and their potential to be developed as multifunctional, we predict they will present an undeniable role in clinical studies and provide treatment platforms for various diseases. Thus, their clearance and interactions with extra- and intra-cellular molecules need to be considered in future projects.
[Mh] Termos MeSH primário: Ouro/química
Nanopartículas Metálicas/química
Nanomedicina Teranóstica
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Estrutura Molecular
Fototerapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
7440-57-5 (Gold)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170703
[St] Status:MEDLINE



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