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[PMID]:29029618
[Au] Autor:Bajgai J; Fadriquela A; Ara J; Begum R; Ahmed MF; Kim CS; Kim SK; Shim KY; Lee KJ
[Ad] Endereço:Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju, Gangwon, 26426, Republic of Korea.
[Ti] Título:Balneotherapeutic effects of high mineral spring water on the atopic dermatitis-like inflammation in hairless mice via immunomodulation and redox balance.
[So] Source:BMC Complement Altern Med;17(1):481, 2017 Oct 13.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Atopic dermatitis (AD) is a chronic relapsing allergic inflammatory skin disease that currently affects millions of children and adults worldwide. Drugs used to treat these inflammatory diseases include anti-histamines, corticosteroids and calcineurin inhibitors but these drugs have their limitations such as adverse effects with their long-term usage. Thus, researcher's interest in several alternative and complementary therapies are continually growing and balneotherapy is one of these approaches. Therefore, we investigate the bathing effect of high concentration mineral spring water (HMW) on redox balance and immune modulation in 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis like inflammation in hairless mice. METHODS: We induced AD-like inflammation by application of DNCB on the dorsal skin of female skh-1 hairless mice. The mice were treated with 100% pure HMW (PHMW) and 10% diluted HMW (DHMW) through bathing once a day for 4 weeks. Tacrolimus ointment (0.1%) was used as positive control (PC) and only DNCB treatment as negative control (NeC) group. The severity of skin lesion inflammation was assessed through clinical scoring and observing scratching behavior. Levels of immunoglobulin E (IgE) and inflammatory cytokines in serum were detected by ELISA and multiplex bead array system, and the levels of oxidative stress-related biomarkers and antioxidant enzyme were also measured. RESULTS: We found that HMW significantly decreased the scratching behavior in PHMW and DHMW groups at the 2nd week and in PHMW group at 4th week compared to NeC group. Likewise, serum IgE level was significantly decreased in DHMW group as compared to NeC group. In line, the level of inflammatory cytokines in serum such as interleukin (IL)-1ß, IL-13 and tumor necrosis factor-α were significantly inhibited in PHMW and DHMW groups compared to NeC group. In parallel, total reactive oxygen species (ROS) of serum level was significantly decreased in PHMW treatment groups compared to NeC group. Consistently, serum malondialdehyde (MDA) level in PHMW group was lower than in NeC group. By contrast, glutathione peroxidase (GPx) activity was significantly enhanced in PHMW than NeC. CONCLUSION: Collectively, our study indicates a balneotherapeutic effect of HMW on DNCB-induced AD like inflammation in hairless mice via immunomodulation and redox balance.
[Mh] Termos MeSH primário: Balneologia
Dermatite Atópica/terapia
Águas Minerais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Dermatite Atópica/induzido quimicamente
Dermatite Atópica/patologia
Dinitroclorobenzeno/efeitos adversos
Modelos Animais de Doenças
Feminino
Imunomodulação
Camundongos
Camundongos Pelados
Oxirredução
Pele/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mineral Waters); GE3IBT7BMN (Dinitrochlorobenzene)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171015
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1985-8


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[PMID]:28374734
[Au] Autor:Bekhterev VN; Kabina EA
[Ad] Endereço:Research Centre of Balneotherapy and Rehabilitation, the branch of the federal state budgetary institution 'North Caucasian Federal Research and Clinical Centre', Russian Federal Medico-Biological Agency, Sochi, Russia; Federal state budgetary educational institution of higher professional education 'Sochi State University', Sochi, Russia.
[Ti] Título:[The isolation of organic compounds from hydrosulfuric mineral waters with the use of the extractive freezing-out technique with centrifugation].
[Ti] Título:Vydelenie organicheskikh veshchestv iz serovodorodnykh mineral'nykh vod metodom ekstraktsionnogo vymorazhivaniya s tsentrifugirovaniem..
[So] Source:Vopr Kurortol Fizioter Lech Fiz Kult;94(1):56-61, 2017.
[Is] ISSN:0042-8787
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The mineral waters, enriched with organic substances find extensive application in balneotherapy. The fast and efficient methods for the identification and quantitative measurement of organic compounds (in the first place, organic acids) in such waters need to be developed for the estimation of their quality and biological activity. AIM: The objective of the present study was to elaborate a gas chromatographic method for the determination of monobasic carbonic acids in sulfide-containing mineral waters by means of extractive freezing-out in combination with the application of the centrifugal forces for the elucidation of the metrological characteristics of the compounds of interest. The secondary objective was to estimate the prospects for the application of the method of interest for determining the dissolved organic compounds in mineral waters. MATERIAL AND METHODS: The following carbonic acids were used for the purposes of the study: acetic acid (analytical grade), Russia; propionic grade (extra pure), Ferak, Germany; butyric acid (pure), Russia; valeric acid (pure), Russia; caproic acid (pure), Russia; oenanthic acid (pure), Russia; and caprylic acid (pure), Russia). Acetonitrile («O¼ grade), Russia, was used as the extracting agent. The LV-210 analytical balance (Russia) was used to prepare the model and standard solutions of the organic compounds and to determine their mass. The extracts and standard mixture were investigated by the gas chromatographic technique with the use of the Kristallyuks apparatus («Meta-Khrom¼, Russia) equipped with the flame ionization detector and the capillary column. Extractive freezing-out in the combination with centrifugation was performed with the laboratory installation for this purpose. RESULTS: Under the model conditions, a single extractive freezing-out procedure with the centrifugation of the sample made it possible to reach the 22-37-fold concentration of C2-C8 monobasic carbonic acids during their transfer from water into acetonitrile. The metrological parameters of the proposed procedure for gas-chromatographic determination of the aforementioned acids in hydrosulfuric mineral waters were estimated. The limit of detection of acetic and propionic acids has been 0,2 mg/l, that for butyric acid 0,1 mg/l, for valeric, caproic, oenanthic and caprylic acids 0,05 mg/l. We failed to identify C2-C8 carbonic acids in hydrosulfuric water from the 6T well of the field Matsesta fields. The investigation of the extracts obtained by the proposed extraction procedure with the use of the newly developed variant of high performance liquid chromatography (HPLC) with diode-matrix detection revealed the presence of various amounts of unknown organic substances. The UV-spectrum of one of those components was obtained which made it possible to conjecture its molecular structure. The procedure for the sample preparation and the following determination of organic acids in water is simple, carried out in a single stage, and does not impose special requirements to the qualification of the researcher. It allows to describe the newly developed technique as a rapid test method. Along with it, realization of extraction in the negative temperature mode reduces the risk of decomposition of the thermally unstable chemical compounds being extracted and reduces volatility of the organic solvents being used. The technology of the method does not demand a special laboratory glassware and expendables.
[Mh] Termos MeSH primário: Ácidos Carboxílicos/isolamento & purificação
Fracionamento Químico/métodos
Congelamento
Sulfeto de Hidrogênio
Águas Minerais/análise
[Mh] Termos MeSH secundário: Balneologia
Estâncias para Tratamento de Saúde
Águas Minerais/normas
Federação Russa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carboxylic Acids); 0 (Mineral Waters); YY9FVM7NSN (Hydrogen Sulfide)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE
[do] DOI:10.17116/kurort201794156-61


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[PMID]:28374725
[Au] Autor:Apsheva EL; El'garov AA; Kalmykova MA; El'garov MA
[Ad] Endereço:Kh.M. Berbekov Kabardino-Balkarian State University, Nal'chik, Russia.
[Ti] Título:[The spa and health resort-based treatment of the women of various employments presenting with arterial hypertension].
[Ti] Título:Sanatornoe lechenie zhenshchin razlichnykh professii s arterial'noi gipertenziei..
[So] Source:Vopr Kurortol Fizioter Lech Fiz Kult;94(1):9-14, 2017.
[Is] ISSN:0042-8787
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:AIM: The objective of the present study was to evaluate the effectiveness of balneotherapy for the women of various employments presenting with arterial hypertension. MATERIAL AND METHODS: The study included 57 women with stage I (n=29) and II (n=28) hypertension. One study group was comprised of 28 female motor drivers including taxi-drivers (n=12), personal car drivers (n=7), and trolleybus drivers (n=9) at the mean age of 46,2±6,9 years suffering from occupational emotional stress (OES) and systematic psychoemotional tension (PET). Another group consisted of 29 female service system operators and included teachers (n=14), medical professionals (n=8), and social workers (n=7) at the mean age of 46.1±7.0 years whose activities was either associated with PET or involved hard emotional labour (HEL). The severity of the disease, and the age of the members of the two groups exposed to PET or HEL were not significantly different. Both groups were formed by means of random assignment. All the patients were subdivided into two groups: group 1 was comprised of 29 women and included 15 service system operators and 14 those exposed to HEL; the major therapeutic factor chosen for their treatment was taking thermal nitrogen mineral baths (36-37 degrees Celsius during 15 min., 8-10 sessions per treatment course). The patients of group 2 (n=28 including 14 service system operators and 14 those exposed to HEL) underwent treatment with the use of bromiodine mineral baths (36-37 degrees Celsius during 15 min., 8-10 sessions per treatment course). ECG, 24hr arterial blood pressure monitoring (ABPM), and psychophyisiological testing (PPT) were used alongside with the routine general clinical examination and laboratory studies to evaluate the outcome and overall effectiveness of balneotherapy. RESULTS: The clinical and instrumental characteristics of the participants in the study (health status, peripheral and coronary hemodynamics, etc.) gave evidence of the considerable improvement in the general health status of 89.6% and 87.7% of the women suffering from arterial hypertension following their treatment with the use of nitric and bromiodnine thermal baths, respectively. At the same time, the patients of group 1 exhibited the marked improvement in the condition of the fast response system while those of group 2 experienced either the deterioration of the occupationally significant functions and characteristics (in 48.3% cases) or did not show their dynamic whatever (in 51.1% cases). CONCLUSION: The present study has demonstrated the high effectiveness of balneotherapy for the women of various professional employments presenting with stage I and II arterial hypertension making use of bromiodine mineral bath therapy even though such treatment resulted in the deterioration of professional functions and qualities in 48.3% of the cases; in contrast, the nitrogen-thermal therapy improved the working capacity of the patients. Based on these observations, it is recommended that the psychophysiological testing should be practiced following balneotherapy before the women with arterial hypertension resume their occupational activities.
[Mh] Termos MeSH primário: Balneologia/métodos
Esgotamento Profissional/terapia
Estâncias para Tratamento de Saúde
Hipertensão/terapia
Águas Minerais
[Mh] Termos MeSH secundário: Pressão Sanguínea/fisiologia
Eletrocardiografia Ambulatorial
Feminino
Frequência Cardíaca/fisiologia
Seres Humanos
Hipertensão/diagnóstico
Meia-Idade
Federação Russa
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mineral Waters)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE
[do] DOI:10.17116/kurort20179419-14


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[PMID]:27709349
[Au] Autor:Kälsch J; Pott LL; Takeda A; Kumamoto H; Möllmann D; Canbay A; Sitek B; Baba HA
[Ad] Endereço:Institute of Pathology, University Hospital of Essen, University of Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.
[Ti] Título:Bathing in carbon dioxide-enriched water alters protein expression in keratinocytes of skin tissue in rats.
[So] Source:Int J Biometeorol;61(4):739-746, 2017 Apr.
[Is] ISSN:1432-1254
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Beneficial effects of balneotherapy using naturally occurring carbonated water (CO enriched) have been known since the Middle Ages. Although this therapy is clinically applied for peripheral artery disease and skin disorder, the underlying mechanisms are not fully elucidated.Under controlled conditions, rats were bathed in either CO -enriched water (CO content 1200 mg/L) or tap water, both at 37 °C, for 10 min daily over 4 weeks. Proliferation activity was assessed by Ki67 immunohistochemistry of the epidermis of the abdomen. The capillary density was assessed by immunodetection of isolectin-positive cells. Using cryo-fixed abdominal skin epidermis, follicle cells and stroma tissue containing capillaries were separately isolated by means of laser microdissection and subjected to proteomic analysis using label-free technique. Differentially expressed proteins were validated by immunohistochemistry.Proliferation activity of keratinocytes was not significantly different in the epidermis after bathing in CO -enriched water, and also, capillary density did not change. Proteomic analysis revealed up to 36 significantly regulated proteins in the analyzed tissue. Based on the best expression profiles, ten proteins were selected for immunohistochemical validation. Only one protein, far upstream element binding protein 2 (FUBP2), was similarly downregulated in the epidermis after bathing in CO -enriched water with both techniques. Low FUBP2 expression was associated with low c-Myc immune-expression in keratinocytes.Long-term bathing in CO -enriched water showed a cellular protein response of epithelial cells in the epidermis which was detectable by two different methods. However, differences in proliferation activity or capillary density were not detected in the normal skin.
[Mh] Termos MeSH primário: Balneologia
Água Carbonatada
Queratinócitos/metabolismo
[Mh] Termos MeSH secundário: Animais
Proliferação Celular
Masculino
Proteômica
Ratos Wistar
Pele/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbonated Water)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161007
[St] Status:MEDLINE
[do] DOI:10.1007/s00484-016-1252-6


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[PMID]:27689602
[Au] Autor:Kavadar G; Demircioglu DT; Can H; Emre TY; Civelek E; Senyigit A
[Ad] Endereço:Physical Medicine and Rehabilitation Department, Gunesli Medicine Hospital, Istanbul, Turkey.
[Ti] Título:The clinical factors associated with benefit finding of complementary medicine use in patients with back pain: A cross-sectional study with cluster analysis.
[So] Source:J Back Musculoskelet Rehabil;30(2):271-277, 2017.
[Is] ISSN:1878-6324
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Complementary and alternative medicine (CAM) use has been increasing. OBJECTIVE: To identify the factors associated with perceived benefit from CAM methods in back problems. METHODS: The study was conducted on patients who practiced any CAM methods due to complaints of back pain. Social-demographic properties, details of CAM methods employed were questioned. Severity of pain was measured by visual analog scale (VAS); benefits were evaluated by the Likert scale. Hierarchical cluster analysis was used to discover relationships among variables. RESULTS: In total, 500 patients (265 female, 235 male) were included in the study. Mostly used methods were herbal therapy (32%), balneotherapy (31%), cupping (19.4%) and massage-manipulation (19.2%). Of patients, 355 (71%) were satisfied. The variables associated with benefit finding were female gender, age, chronicity and severity of pain, high educational level, upper middle income status, use as a result of recommendation, dissatisfaction with conventional methods, residence in an urban area, non-herbal method use, being married, and social insurance (p < 0.005). CONCLUSION: The majority of patients using CAM perceived benefits; in particular, women living in urban areas, highly educated, aged more than 40, who suffer from severe chronic back pain, may be more inclined to go to CAM therapists.
[Mh] Termos MeSH primário: Terapia por Acupuntura
Dor nas Costas/terapia
Balneologia
Terapias Complementares/métodos
Massagem
Fitoterapia
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Idoso
Idoso de 80 Anos ou mais
Estudos Transversais
Escolaridade
Feminino
Seres Humanos
Masculino
Estado Civil
Meia-Idade
Satisfação do Paciente
Fatores Sexuais
Fatores Socioeconômicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170518
[Lr] Data última revisão:
170518
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161001
[St] Status:MEDLINE
[do] DOI:10.3233/BMR-150470


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[PMID]:27324882
[Au] Autor:Karagülle M; Kardes S; Karagülle O; Disçi R; Avci A; Durak I; Karagülle MZ
[Ad] Endereço:Department of Medical Ecology and Hydroclimatology, Istanbul Faculty of Medicine, Istanbul University, Tibbi Ekoloji ve Hidroklimatoloji A.B.D. Istanbul Tip Fakültesi Fatih, Capa, 34093, Istanbul, Turkey. mkgulle@istanbul.edu.tr.
[Ti] Título:Effect of spa therapy with saline balneotherapy on oxidant/antioxidant status in patients with rheumatoid arthritis: a single-blind randomized controlled trial.
[So] Source:Int J Biometeorol;61(1):169-180, 2017 Jan.
[Is] ISSN:1432-1254
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Oxidative stress has been shown to play a contributory role in the pathogenesis of rheumatoid arthritis (RA). Recent studies have provided evidence for antioxidant properties of spa therapy. The purpose of this study is to investigate whether spa therapy with saline balneotherapy has any influence on the oxidant/antioxidant status in patients with RA and to assess clinical effects of spa therapy. In this investigator-blind randomized controlled trial, we randomly assigned 50 patients in a 1:1 ratio to spa therapy plus standard drug treatment (spa group) or standard drug treatment alone (control group). Spa group followed a 2-week course of spa therapy regimen consisting of a total of 12 balneotherapy sessions in a thermal mineral water pool at 36-37 °C for 20 min every day except Sunday. All clinical and biochemical parameters were assessed at baseline and after spa therapy (2 weeks). The clinical parameters were pain intensity, patient global assessment, physician global assessment, Health Assessment Questionnaire disability index (HAQ-DI), Disease Activity Score for 28-joints based on erythrocyte sedimentation rate (DAS28-4[ESR]). Oxidative status parameters were malondialdehyde (MDA), nonenzymatic superoxide radical scavenger activity (NSSA), antioxidant potential (AOP), and superoxide dismutase (SOD). The NSSA levels were increased significantly in the spa group (p = 0.003) but not in the control group (p = 0.509); and there was a trend in favor of spa therapy for improvements in NSSA levels compared to control (p = 0.091). Significant clinical improvement was found in the spa group compared to the control in terms of patient global assessment (p = 0.011), physician global assessment (p = 0.043), function (HAQ-DI) (p = 0.037), disease activity (DAS28-4[ESR]) (0.044) and swollen joint count (0.009), and a trend toward improvement in pain scores (0.057). Spa therapy with saline balneotherapy exerts antioxidant effect in patients with RA as reflected by the increase in NSSA levels after spa therapy; whether this antioxidant effect contributes to the clinical improvements observed remains to be verified.
[Mh] Termos MeSH primário: Antioxidantes
Artrite Reumatoide/terapia
Balneologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Malondialdeído/sangue
Meia-Idade
Manejo da Dor
Método Simples-Cego
Superóxido Dismutase/sangue
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Antioxidants); 4Y8F71G49Q (Malondialdehyde); EC 1.15.1.1 (Superoxide Dismutase)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160622
[St] Status:MEDLINE
[do] DOI:10.1007/s00484-016-1201-4


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[PMID]:28644605
[Au] Autor:Roques CF; Queneau P
[Ti] Título:[SPA therapy for pain of patients with chronic low back pain, knee osteo-arthritis and fibromyalgia].
[Ti] Título:Médecines thermals et douleurs des lombalgies chroniques, gonarthrose ou fibromyalgia..
[So] Source:Bull Acad Natl Med;200(3):575-86; discussion 586-7, 2016 03.
[Is] ISSN:0001-4079
[Cp] País de publicação:Netherlands
[La] Idioma:fre
[Ab] Resumo:The data of 33 randomized controlled trials suggest that chronic pain of patients with chronic low back pain, knee osteo-arthritis, fibromyalgia is significantly improved by balneotherapy and significantly better improved than by control treatments. For chronic low back pain (10 RCT, 1192 patients) pain was better improved in balneotherapy group and the weighted mean of the differential improvement was 19.66 (95 % CI: 16.6 ; 22.8) and the effect size was 1.1 (95 %CI: 0.82 ; 1.38) favouring balneotherapy. For knee osteo-arthritis pain (17 RCT, 1428 patients) pain was better improved in balneotherapy group and the weighted mean of the differential improvement was 13.24 (95 % CI: 5.52 ; 20.96) and the effect size was 0.72 (95 %CI: 0.51 ; 0.93) favouring balneotherapy. For fibromyalgia (6 RCT, 398 patients) pain was better improved in balneotherapy group and the weighted mean of the differential improvement was 19.32 (95 % CI: 10.62 ; 29.2) and the effect size was 0.79 (95 %CI: 0.27 ; 1.31) favouring balneotherapy. Mineral waters and healing muds appear to have a more powerful analgesic action: 13 RCT (701) patients) compared mineral water bathing to tap water bathing or peloid application to hot-apcks or neutral muds application : the effect size was 0.75 (95 % CI :0.71 ; 0.79) favouring balneotherapy. Balneotherapy is a safe treatment as only 1 % of the patients receiving balneotherapy had to interrupt the treatment. However several methodological biases were observed in many trials, mainly a lack of statistical power due to a limited enrolment of patients, an insufficient duration of follow-up, an inhomogeneity of treatments. The clinical benefit has to be confirmed by stronger data of evidence but these data are sufficient to perform a more complete scientific analysis (meta-analysis) ; but further clinical investigations with a better methodological quality remain necessary.
[Mh] Termos MeSH primário: Balneologia
Fibromialgia/terapia
Dor Lombar/terapia
Osteoartrite do Joelho/terapia
[Mh] Termos MeSH secundário: Balneologia/métodos
Dor Crônica/terapia
Seres Humanos
Metanálise como Assunto
Ensaios Clínicos Controlados Aleatórios como Assunto/estatística & dados numéricos
Literatura de Revisão como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170624
[St] Status:MEDLINE


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[PMID]:28247650
[Au] Autor:Saenko VS; Gazimiev MA; Pesegov SV
[Ad] Endereço:I.M. Sechenov First MSMU, Department of Urology.
[Ti] Título:[The place of mineral water in the metaphylaxis of urolithiasis].
[So] Source:Urologiia;(2 Suppl 2):87-94, 2016 Apr.
[Is] ISSN:1728-2985
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Urinary stone disease is a metabolic disorder tending to recur and having a growing proportion of younger patients. Current methods of surgical treatment do not guarantee the disease non-recurrence without effective subsequent metaphylaxis. At present, the principles of general and special (medical) metaphylaxis of urolithiasis have been developed and widely applied according to underlying metabolic disorders, the type of stone formation and risk factors for recurrence. Oversaturation of the urine with stone forming substances is a major factor in stone formation. Recommendations for using mineral water should not be given without a clear understanding of the expected effect of particular water. Its selection for treating urolithiasis depends on the chemical composition of the stones, underlying metabolic disorders, urine pH, the functional state of the gastrointestinal tract, concomitant diseases, etc.
[Mh] Termos MeSH primário: Balneologia/métodos
Águas Minerais/uso terapêutico
Urolitíase/prevenção & controle
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Mineral Waters)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE


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[PMID]:27964734
[Au] Autor:Trabelsi L; Mnari A; Abdel-Daim MM; Abid-Essafi S; Aleya L
[Ad] Endereço:Laboratory of Marine Biodiversity and Biotechnology, National Institute of Marine Sciences and Technology, BP 59, Monastir, 5000, Tunisia.
[Ti] Título:Therapeutic properties in Tunisian hot springs: first evidence of phenolic compounds in the cyanobacterium Leptolyngbya sp. biomass, capsular polysaccharides and releasing polysaccharides.
[So] Source:BMC Complement Altern Med;16(1):515, 2016 Dec 13.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In Tunisia, the use of hot spring waters for both health and recreation is a tradition dating back to Roman times. In fact, thermal baths, usually called "Hammam" are recommended as a therapeutic and prophylactic measure against many types of illness and toxicity. While the chemical concentration of thermal water is admittedly associated with its therapeutic effects, the inclusion in spa waters of efficient bioproduct additives produced by photosynthetic microorganisms and that act against oxidative stress may comprise a significant supplementary value for thermal centers. The aim of this study was to investigate the antioxidant potential of the Tunisian thermophilic cyanobacterium Leptolyngbya sp. and to determine its phytochemical constituents and phenolic profile. METHODS: BME (Biomass Methanolic Extract), CME (Capsular polysaccharides Methanolic Extract) and RME (Releasing polysaccharides Methanolic Extract) of Leptolyngbya sp. were examined for their antioxidant activities by means of DPPH, hydroxyl radical scavenging and ferrous ion chelating assays. Their total phenols, flavonoids, carotenoids, Mycosporine-like amino acids (MAAs) and vitamin C contents, as well as their phenolic profiles were also determined. RESULTS: BME has the highest content of phenols (139 ± 1.2 mg/g), flavonoids (34.9 ± 0.32 mg CEQ/g), carotenoids (2.03 ± 0.56 mg/g) and vitamin C (15.7 ± 1.55 mg/g), while the highest MAAs content (0.42 ± 0.03 mg/g) was observed in CME. BME presented both the highest DPPH and hydroxyl radical scavenging ability with an IC of 0.07 and 0.38 mg/ml, respectively. The highest ferrous chelating capacity was detected in CME with an IC = 0.59 mg/ml. Phenolic profiles revealed the presence of 25 phenolic compounds with the existence of hydroxytyrosol, oleuropein, resveratrol and pinoresinol. CONCLUSION: The study demonstrated that the cyanobacterium Leptolyngbya sp. possesses abundant natural antioxidant products which may have prophylactic and therapeutic effects on many types of illness and toxicity. The present findings not only explain and reinforce the rationale behind traditional therapeutic practices in Tunisia in the exploitation of the country's hot springs, but support the addition of Leptolyngbya to thermal waters as a means to enhance the value and reputation of the curative nature of Tunisian thermal waters.
[Mh] Termos MeSH primário: Balneologia
Cianobactérias/química
Fontes Termais/química
Fenóis/análise
[Mh] Termos MeSH secundário: Antioxidantes/análise
Biomassa
Carotenoides/análise
Cromatografia Líquida de Alta Pressão
Flavonoides/análise
Polissacarídeos/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flavonoids); 0 (Phenols); 0 (Polysaccharides); 36-88-4 (Carotenoids)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161215
[St] Status:MEDLINE


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[PMID]:27938361
[Au] Autor:Lanhers C; Pereira B; Gay C; Hérisson C; Levyckyj C; Dupeyron A; Coudeyre E
[Ad] Endereço:Physical Medicine and Rehabilitation, University Hospital of Clermont-Ferrand (CHU), 58, rue de Montalembert, 63000, Clermont-Ferrand, France. lanhers.charlotte@gmail.com.
[Ti] Título:Evaluation of the efficacy of a short-course, personalized self-management and intensive spa therapy intervention as active prevention of musculoskeletal disorders of the upper extremities (Muska): a research protocol for a randomized controlled trial.
[So] Source:BMC Musculoskelet Disord;17(1):497, 2016 Dec 09.
[Is] ISSN:1471-2474
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Musculoskeletal disorders (MSDs) constitute a major occupational health problem in the working population, substantially impacting the quality of life of employees. They also cause considerable economic cost to the healthcare system, with, notably, the reimbursement of treatments and compensation for lost income. MSDs manifest as localized pain or functional difficulty in one or more anatomical areas, such as the cervical spine, shoulder, elbow, hand, and wrist. Although prevalence varies depending on the region considered and the method of assessment, a prevalence of 30% is found in different epidemiological studies. The disease needs to be prevented, not only for medical and economic reasons, but also for legal reasons, owing to the requirement of assessing occupational risks. The strategy envisaged may thus revolve around active, multimodal prevention that has employees fully involved at the heart of their care. Although physical exercise is widely recommended, few studies with a good level of evidence have enabled us to base a complete, well-constructed intervention on exercise that can be offered as secondary prevention in these disorders. METHODS: A prospective, multicenter, comparative (intervention arm vs. control arm), randomized (immediate vs. later treatment) study using Zelen's design. This study falls under active prevention of MSDs of the upper extremities (UE-MSDs). Participants are workers aged between 18 and 65 years with latent or symptomatic MSDS, with any type of job or workstation, with or without an history of sick leave. The primary aim is to show the superiority at 3 months of a combination of spa therapy, exercise, and self-management workshops for 6 days over usual care in the management of MSDs in terms of employee functional capacity in personal and professional daily life. Secondary aims are to assess the benefit of the intervention in terms of pain, quality of life, and accumulated duration of sick leave. DISCUSSION: This randomized controlled trial is the first that will aim to evaluate multidisciplinary management of UE-MSDs using nonpharmacological treatment combining exercise, self-management, and spa therapy. The originality of this intervention lies, in its short, intensive format, which is compatible with remaining in work; and in its multidisciplinary approach. This trial has the potential to demonstrate, with a good level of evidence, the benefits of a short course of spa therapy combined with a personalized self-management program on the functional capacity, pain, and quality of life of employees in their daily life. TRIAL REGISTRATION: Clinical trial.gov NCT02702466 retrospectively registered. PROTOCOL: Version 4 of 9/10/2015.
[Mh] Termos MeSH primário: Balneologia/métodos
Terapia por Exercício/métodos
Doenças Musculoesqueléticas/prevenção & controle
Doenças Profissionais/prevenção & controle
Medicina de Precisão/métodos
Autocuidado/métodos
[Mh] Termos MeSH secundário: Seres Humanos
Doenças Musculoesqueléticas/economia
Doenças Musculoesqueléticas/epidemiologia
Doenças Profissionais/economia
Doenças Profissionais/epidemiologia
Saúde do Trabalhador/economia
Prevalência
Estudos Prospectivos
Qualidade de Vida
Projetos de Pesquisa
Licença Médica/estatística & dados numéricos
Fatores de Tempo
Extremidade Superior
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE



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