Base de dados : MEDLINE
Pesquisa : E02.056.110 [Categoria DeCS]
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  1 / 4149 MEDLINE  
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[PMID]:29381914
[Au] Autor:Wang Z; Zheng J; Zhao Y; Xiang Y; Chen X; Zhao F; Jin Y
[Ad] Endereço:Department of Orthopaedics, Henan Provincial People's Hospital.
[Ti] Título:Preoperative bathing with chlorhexidine reduces the incidence of surgical site infections after total knee arthroplasty: A meta-analysis.
[So] Source:Medicine (Baltimore);96(47):e8321, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Surgical site infection is a devastating postoperative complication, and the occurrence ranges from 1% to 2% after total knee arthroplasty (TKA). The efficacy of the preoperative use of chlorhexidine for reducing infection has been debated. This meta-analysis aimed to examine the efficacy of the use of chlorhexidine to prevent surgical site infections after TKA. METHODS: In February 2017, a systematic literature review was conducted using the following electronic databases: PubMed, EMBASE, Web of Science, Cochrane Database of Systematic Reviews, and the Google database. Data from randomized controlled trials (RCTs) and retrospective comparative study (RCS) that compared the use of chlorhexidine versus control washes to prep patients for TKA were retrieved. The primary endpoint was to compare the total incidence of infection with and without the use of chlorhexidine. The secondary outcomes were the incidence of infection in low-risk category patients, moderate-risk category patients, and high-risk category patients. After testing for publication bias and heterogeneity between studies, data were aggregated for random-effects modeling when necessary. RESULTS: Four clinical trials that included 8787 patients (chlorhexidine group: n = 2615, control group: n = 6172) were ultimately included in the meta-analysis. Chlorhexidine was associated with a reduced total incidence of infection, corresponding to a reduction of 1.69% [risk ratio (RR) = 0.22; 95% confidence interval (95% CI) = 0.12-0.40; P = .000]. Similarly, chlorhexidine was associated with a reduction in the incidence of infection among patients in the moderate-risk category (RR, 0.18; 95% CI, 0.05-0.63; P = .007) and the high-risk category (RR, 0.13; 95% CI, 0.03-0.67; P = .014). There was no significant difference between the incidence of infection in low-risk category patients with chlorhexidine use compared with the use of control washes (RR, 0.60; 95% CI, 0.22-1.60; P = .330). CONCLUSION: The preoperative use of chlorhexidine could reduce the total incidence of infection and the incidence of infection in moderate-risk and high-risk category patients. The overall evidence and the number of included studies was limited; thus, a greater number of high-quality RCTs is still needed to further identify the effects of chlorhexidine on reducing the incidence of infection after TKA.
[Mh] Termos MeSH primário: Anti-Infecciosos Locais/administração & dosagem
Artroplastia do Joelho/métodos
Banhos/métodos
Clorexidina/administração & dosagem
Infecção da Ferida Cirúrgica/prevenção & controle
[Mh] Termos MeSH secundário: Seres Humanos
Cuidados Pré-Operatórios
Estudos Retrospectivos
Fatores de Risco
Autocuidado
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Nm] Nome de substância:
0 (Anti-Infective Agents, Local); R4KO0DY52L (Chlorhexidine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008321


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[PMID]:29223208
[Au] Autor:Brogan J; Rapkin G
[Ti] Título:Implementing Evidence-Based Neonatal Skin Care With Parent-Performed, Delayed Immersion Baths.
[So] Source:Nurs Womens Health;21(6):442-450, 2017 Dec.
[Is] ISSN:1751-486X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:There has been a recent trend toward delaying newborn baths because of mounting evidence that delayed bathing promotes breastfeeding, decreases hypothermia, and allows for more parental involvement with newborn care. A multidisciplinary team from a maternal-new-born unit at a military medical center designed and implemented an evidence-based practice change from infant sponge baths shortly after birth to delayed immersion baths. An analysis of newborn temperature data showed that newborns who received delayed immersion baths were less likely to be hypothermic than those who received a sponge bath shortly after birth. Furthermore, parents reported that they liked participating in bathing their newborns and that they felt prepared to bathe them at home.
[Mh] Termos MeSH primário: Banhos/métodos
Saúde do Lactente/normas
Pais/educação
Higiene da Pele/métodos
Fatores de Tempo
[Mh] Termos MeSH secundário: Aleitamento Materno/métodos
Aleitamento Materno/tendências
Feminino
Seres Humanos
Hipotermia/prevenção & controle
Imersão
Cuidado do Lactente/métodos
Cuidado do Lactente/tendências
Recém-Nascido
Estudos Retrospectivos
Higiene da Pele/tendências
Inquéritos e Questionários
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:171211
[St] Status:MEDLINE


  3 / 4149 MEDLINE  
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[PMID]:28771156
[Au] Autor:Karakaya MÇ; Dogru M; Karakaya N; Kuluöztürk F; Nalbantçilar MT
[Ad] Endereço:Selçuk University Engineering Faculty Geological Engineering Department, Konya 42079, Turkey E-mail: mcelik@selcuk.edu.tr.
[Ti] Título:Radioactivity and hydrochemical properties of certain thermal Turkish spa waters.
[So] Source:J Water Health;15(4):591-601, 2017 Aug.
[Is] ISSN:1477-8920
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The study aims to determine the radioactivity levels of thermal waters which have been used seasonally or permanently in spas for therapeutic intentions. Samples were collected from spas in different regions of Turkey. Some radionuclides ( K, Th, Ra, Cs), gross alpha (GA) and gross beta (GB) activities, and physical and some chemical parameters were measured. Gamma radiation measurements for Ra, Th and K radionuclides were performed by using a high purity germanium (HPGe) detector. The results of the gamma spectrometry ranged from 1.385 to 11.025 Bql for Ra,
[Mh] Termos MeSH primário: Águas Minerais/análise
Radioisótopos/análise
Poluentes Radioativos da Água/análise
[Mh] Termos MeSH secundário: Banhos
Monitoramento Ambiental
Monitoramento de Radiação
Espectrometria gama
Turquia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mineral Waters); 0 (Radioisotopes); 0 (Water Pollutants, Radioactive)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.2166/wh.2017.263


  4 / 4149 MEDLINE  
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[PMID]:28762227
[Au] Autor:Lin SC; Lin CH; Yu CC
[Ad] Endereço:Graduate Institute of Nursing, Central Taiwan University of Science and Technology, Taiwan, ROC.
[Ti] Título:[Chlorhexidine Bed-Bath Improves CLABSI: A Meta-Analysis].
[So] Source:Hu Li Za Zhi;64(4):71-78, 2017 Aug.
[Is] ISSN:0047-262X
[Cp] País de publicação:China (Republic : 1949- )
[La] Idioma:chi
[Ab] Resumo:BACKGROUND: Central catheters are used primarily in ICU settings. Bloodstream infections in the central line of central catheters have been shown to cause longer hospital stays for patients and result in higher medical costs. PURPOSE: The present study applies a systematic review and meta-analysis to assess the effect of a 2% chlorhexidine (CHG) bed-bath on the risk of central line-associated bloodstream infections (CLABSI). METHODS: The Public Health Resource Unit of England issued the Critical Appraisal Skills Programme and evaluated the standardized crucial appraisal tools from the Joanna Briggs Institute that are used to assess methodological quality. The present study identified 6 studies that met the criteria from a keyword search that included: CHG and soap-water for bed-bath experiment. The experiment used RevMan 5 software to conduct the meta- analysis. RESULTS: The results support the homogeneity (p = .002, I = 64%) of the sample. Comprehensive effectiveness was 0.45 (95% CI [0.35, 0.58], p < .001). The CHG bed-bath intervention was shown to effectively reduce CLABSI. CONCLUSIONS / IMPLICATIONS FOR PRACTICE: The meta-analysis indicated that bed-bath with CHG reduces the incidence of CLABSI. We recommend that center catheter bundle care be applied in ICUs in combination with CHG bed-bath in order to reduce the risk of CLABSI.
[Mh] Termos MeSH primário: Banhos
Infecções Relacionadas a Cateter/prevenção & controle
Cateterismo Venoso Central/efeitos adversos
Clorexidina/administração & dosagem
Infecção Hospitalar/prevenção & controle
Sepse/prevenção & controle
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Nm] Nome de substância:
R4KO0DY52L (Chlorhexidine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM; N
[Da] Data de entrada para processamento:170802
[St] Status:MEDLINE


  5 / 4149 MEDLINE  
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[PMID]:28691581
[Au] Autor:Whitworth-Turner C; Di Michele R; Muir I; Gregson W; Drust B
[Ad] Endereço:a Football Exchange, Research Institute for Sport and Exercise Sciences , Liverpool John Moores University , Liverpool , UK.
[Ti] Título:A shower before bedtime may improve the sleep onset latency of youth soccer players.
[So] Source:Eur J Sport Sci;17(9):1119-1128, 2017 Oct.
[Is] ISSN:1536-7290
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:During the competitive season, soccer players are likely exposed to numerous factors that may disrupt the process of sleep. The current investigation looked to evaluate a practical sleep hygiene strategy (10-min showering at ∼40°C before lights out), within a group of 11 youth soccer players in comparison to normal sleeping conditions (control). Each condition consisted of three days within a randomised crossover trial design. Sleep information was collected using a commercial wireless bedside sleep monitor. Measures of skin temperature were evaluated using iButton skin thermistors to establish both distal and proximal skin temperatures and distal to proximal gradient. The shower intervention elevated distal skin temperature by 1.1°C (95% CI: 0.1-2.1°C, p = .04) on average prior to lights out. The elevation in distal temperature was also present during the first 30-min following lights out (1.0°C, 95% CI: 0.4-1.6°C, p < .01). The distal to proximal gradient also showed a significant effect between the conditions within the first 30-min after lights out (0.7°C, 95% CI: 0.3-1.2°C, p < .01). On average the sleep latency of the youth soccer players was -7-min lower (95% CI: -13 to -2 min, p < .01) and sleep efficiency +2% higher (95% CI: 1-3%; p < .01) in the shower condition. These findings demonstrate that a warm shower performed before lights out may offer a practical strategy to promote thermoregulatory changes that may advance sleep onset latency and improve sleep efficiency in athletes.
[Mh] Termos MeSH primário: Banhos
Higiene do Sono
Sono/fisiologia
Futebol
[Mh] Termos MeSH secundário: Adolescente
Atletas
Estudos Cross-Over
Seres Humanos
Masculino
Polissonografia
Temperatura Cutânea
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170711
[St] Status:MEDLINE
[do] DOI:10.1080/17461391.2017.1346147


  6 / 4149 MEDLINE  
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[PMID]:28686959
[Au] Autor:Miranda RPR; de Cássia Lopes Chaves É; Silva Lima R; Braga CG; Simões IAR; Fava SMCL; Iunes DH
[Ad] Endereço:Federal University of Alfenas, Alfenas, Minas Gerais, Brazil. Electronic address: renatapr85@gmail.com.
[Ti] Título:The effectiveness of a simulated scenario to teach nursing students how to perform a bed bath: A randomized clinical trial.
[So] Source:Nurse Educ Today;57:17-23, 2017 Oct.
[Is] ISSN:1532-2793
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Simulation allows students to develop several skills during a bed bath that are difficult to teach only in traditional classroom lectures, such as problem-solving, student interactions with the simulator (patient), reasoning in clinical evaluations, evaluation of responses to interventions, teamwork, communication, security and privacy. OBJECTIVES: This study aimed to evaluate the effectiveness of a simulated bed bath scenario on improving cognitive knowledge, practical performance and satisfaction among nursing students. DESIGN: Randomized controlled clinical trial. SETTING: Nursing students that were in the fifth period from two educational institutions in Brazil. PARTICIPANTS: Nursing students (n=58). METHOD: The data were collected using the assessments of cognitive knowledge, practical performance and satisfaction were made through a written test about bed baths, an Objective Structured Clinical Examination (OSCE) and a satisfaction questionnaire. RESULTS: We identified that the acquisition and assimilation of cognitive knowledge was significantly higher in the simulation group (p=0.001). The performance was similar in both groups regardless of the teaching strategy (p=0.435). At follow-up, the simulation group had significantly more satisfaction with the teaching method than the control group (p=0.007). CONCLUSION: The teaching strategy based on a simulated scenario of a bed bath proved to be effective for the acquisition of cognitive knowledge regarding bed baths in clinical practice and improved student satisfaction with the teaching process.
[Mh] Termos MeSH primário: Banhos/métodos
Competência Clínica
Avaliação Educacional/métodos
Estudantes de Enfermagem/psicologia
[Mh] Termos MeSH secundário: Brasil
Bacharelado em Enfermagem
Feminino
Seres Humanos
Masculino
Manequins
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE


  7 / 4149 MEDLINE  
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[PMID]:28654710
[Au] Autor:Stein Gold LF; Eichenfield LF
[Ad] Endereço:Henry Ford Health System, Detroit, Michigan, USA. lstein1@hfhs.org.
[Ti] Título:Nonpharmacologic strategies and topical agents for treating atopic dermatitis: an update.
[So] Source:Semin Cutan Med Surg;36(2 Suppl 2):S42-S44, 2017 Mar.
[Is] ISSN:1085-5629
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The signs and symptoms of atopic dermatitis can be safely and effectively controlled in most patients; in many cases, the disease can be improved to the point that signs and symptoms are absent or minimal. In addition, flares can be effectively controlled and, in some cases, prevented. New topical medications, improved strategies for the use of topical corticosteroids and topical calcineurin inhibitors, and judicious use of nonpharmacologic regimens-including bathing, bleach baths, and early use of emollients-have led to better disease management and improved quality of life for patients and their families.
[Mh] Termos MeSH primário: Dermatite Atópica/terapia
[Mh] Termos MeSH secundário: Administração Tópica
Banhos
Inibidores de Calcineurina/uso terapêutico
Emolientes/uso terapêutico
Glucocorticoides/uso terapêutico
Seres Humanos
Dermatopatias Bacterianas/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Calcineurin Inhibitors); 0 (Emollients); 0 (Glucocorticoids)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170727
[Lr] Data última revisão:
170727
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE
[do] DOI:10.12788/j.sder.2017.011


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[PMID]:28608300
[Au] Autor:Rajsz A; Wojtun B; Bytnerowicz A
[Ad] Endereço:Department of Ecology, Biogeochemistry and Environmental Protection, Wroclaw University, Kanonia 6/8, 50-328, Wroclaw, Poland. adam.rajsz@uwr.edu.pl.
[Ti] Título:In situ assay of nitrate reductase activity using portable water bath.
[So] Source:Environ Monit Assess;189(7):332, 2017 Jul.
[Is] ISSN:1573-2959
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In environmental research (i.e., plant ecophysiology, environmental microbiology, and environmental chemistry), some assays require incubation of samples at controlled temperature and darkness. Until now, due to a lack of equipment providing such possibility in situ, researchers had to move collected samples to the laboratory for incubation. Obviously, a delayed incubation and the ex situ conditions could seriously affect the assays' results. A good example of analysis where water bath use is needed is the nitrate reductase activity (NRA) in vivo assay where plant tissue samples are incubated in buffer solution at a predetermined temperature. We designed a transportable water bath with a temperature control which enables in situ measurements in many types of environmental studies. The presented device is small in size featuring a thermally insulated chamber and an electronically controlled thermostat system powered by a 12-V battery. Due to its modular design, it can be transported comfortably in difficult terrain. The incubation process can be carried out continuously in stable temperature and darkness. In order to examine the field usability of the presented device, we conducted measurements of plant nitrate reductase activity in difficult field conditions. The in situ assays were carried out at high altitudes in the Karkonosze mountains, SW Poland. The NRA was studied in two alpine species (Deschampsia caespitosa and Homogyne alpina). Our results showed low NR activity in H. alpina (mean 0.31 µM NO g DW h ) and higher NRA in D. caespitosa (mean 2.7 µM NO g DW h ). The obtained results were highly reproducible and had small variability (low standard error values).
[Mh] Termos MeSH primário: Bioensaio/instrumentação
Monitoramento Ambiental/instrumentação
Nitrato Redutase/análise
[Mh] Termos MeSH secundário: Banhos
Escuridão
Nitrato Redutase/metabolismo
Nitrato Redutases
Nitratos
Oxirredução
Raízes de Plantas/metabolismo
Poaceae/metabolismo
Polônia
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nitrates); 059QF0KO0R (Water); EC 1.7.- (Nitrate Reductases); EC 1.7.99.4 (Nitrate Reductase)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170718
[Lr] Data última revisão:
170718
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170614
[St] Status:MEDLINE
[do] DOI:10.1007/s10661-017-6045-9


  9 / 4149 MEDLINE  
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[PMID]:28578808
[Au] Autor:Ishikawa M; Tanaka Y; Suzuki R; Kimura K; Tanaka K; Kamiya K; Ito H; Kato S; Kamachi T; Hori K; Nakanishi S
[Ad] Endereço:Department of Biotechnology, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan; Research Center for Solar Energy Chemistry, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan.
[Ti] Título:Real-time monitoring of intracellular redox changes in Methylococcus capsulatus (Bath) for efficient bioconversion of methane to methanol.
[So] Source:Bioresour Technol;241:1157-1161, 2017 Oct.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study aimed to develop a novel method for real-time monitoring of the intracellular redox states in a methanotroph Methylococcus capsulatus, using Peredox as a genetically encoded fluorescent sensor of the NADH:NAD ratio. As expected, the fluorescence derived from the Peredox-expressing M. capsulatus transformant increased by supplementation of electron donor compounds (methane and formate), while it decreased by specifically inhibiting the methanol oxidation reaction. Electrochemical measurements confirmed that the Peredox fluorescence reliably represents the intracellular redox changes. This study is the first to construct a reliable redox-monitoring method for methanotrophs, which will facilitate to develop more efficient methane-to-methanol bioconversion processes.
[Mh] Termos MeSH primário: Metano
Metanol
Methylococcus capsulatus
[Mh] Termos MeSH secundário: Banhos
Reatores Biológicos
Oxirredução
Oxigenases
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 1.13.- (Oxygenases); OP0UW79H66 (Methane); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE


  10 / 4149 MEDLINE  
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[PMID]:28562289
[Au] Autor:Steele DW; Adam GP; Di M; Halladay CW; Balk EM; Trikalinos TA
[Ad] Endereço:Evidence-Based Practice Center, Center for Evidence Synthesis in Health, and dale_steele@brown.edu.
[Ti] Título:Prevention and Treatment of Tympanostomy Tube Otorrhea: A Meta-analysis.
[So] Source:Pediatrics;139(6), 2017 Jun.
[Is] ISSN:1098-4275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Children with tympanostomy tubes often develop ear discharge. OBJECTIVE: Synthesize evidence about the need for water precautions (ear plugs or swimming avoidance) and effectiveness of topical versus oral antibiotic treatment of otorrhea in children with tympanostomy tubes. DATA SOURCES: Searches in Medline, the Cochrane Central Trials Registry and Cochrane Database of Systematic Reviews, Excerpta Medica Database, and the Cumulative Index to Nursing and Allied Health Literature. STUDY SELECTION: Abstracts and full-text articles independently screened by 2 investigators. DATA EXTRACTION: 25 articles were included. RESULTS: One randomized controlled trial (RCT) in children assigned to use ear plugs versus no precautions reported an odds ratio (OR) of 0.68 (95% confidence interval, 0.37-1.25) for >1 episode of otorrhea. Another RCT reported an OR of 0.71 (95% confidence interval, 0.29-1.76) for nonswimmers versus swimmers. Network meta-analyses suggest that, relative to oral antibiotics, topical antibiotic-glucocorticoid drops were more effective: OR 5.3 (95% credible interval, 1.2-27). The OR for antibiotic-only drops was 3.3 (95% credible interval, 0.74-16). Overall, the topical antibiotic-glucocorticoid and antibiotic-only preparations have the highest probabilities, 0.77 and 0.22 respectively, of being the most effective therapies. LIMITATIONS: Sparse randomized evidence (2 RCTs) and high risk of bias for nonrandomized comparative studies evaluating water precautions. Otorrhea treatments include non-US Food and Drug Administration approved, off-label, and potentially ototoxic antibiotics. CONCLUSIONS: No compelling evidence of a need for water precautions exists. Cure rates are higher for topical drops than oral antibiotics.
[Mh] Termos MeSH primário: Otopatias/prevenção & controle
Dispositivos de Proteção das Orelhas
Ventilação da Orelha Média
Natação
[Mh] Termos MeSH secundário: Banhos
Criança
Seres Humanos
Otite Média com Derrame/prevenção & controle
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
059QF0KO0R (Water)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE



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