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[PMID]:29394011
[Au] Autor:Saladino R; Chiocchini U; Botta G; Delfino M; Conigliaro R; Mosesso P
[Ti] Título:Free radical scavenging capacity and protective effect of natural substances in peloids from the thermal spring pool Bagnaccio (Viterbo, Italy).
[So] Source:J Cosmet Sci;67(2):71-92, 2016 Mar-Apr.
[Is] ISSN:1525-7886
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Natural peloids from sulfurous thermal springs are largely used in cosmetic and pelotherapy for the treatment of different dermatological conditions, including skin aging, dermatitis, and other eczemas. The beneficial effects are correlated to mineralogical and other thermal properties, as well as to the presence of natural substances with specific antioxidant activity. Few data are available for the comparison between natural peloids and synthetic (i.e., artificially maturated) muds. In this context, the natural substances and antioxidant activity of natural white mud (WM) and dark mud (DM) peloids from the sulfurous thermal spring pool Bagnaccio (Viterbo, Italy) have been studied in detail to evaluate possible relationships between physicochemical properties and therapeutic effect. A large panel of natural substances in WM and DM were characterized for the first time by ³¹P-nuclear magnetic resonance and gas chromatography associated to mass spectrometry analysis. Polar fractions of WM and DM peloids were characterized by the presence of several bioactive natural compounds, showing high antioxidant activity and DNA protective effect, as evaluated by 2,2-diphenyl-1-picrylhydrazyl assay, and hydrogen peroxide­induced DNA breakage in the alkaline comet assay. The antioxidant activity and DNA protective effect could be attributed to radical scavenging rather than a modulatory effect on the induced DNA repair, and are of order of intensity higher than that reported for synthetic muds.
[Mh] Termos MeSH primário: Alcaloides/farmacologia
Depuradores de Radicais Livres/farmacologia
Hidrocarbonetos Aromáticos/farmacologia
Fenóis/farmacologia
Terpenos/farmacologia
[Mh] Termos MeSH secundário: Alcaloides/química
Alcaloides/isolamento & purificação
Alcanos/química
Alcanos/isolamento & purificação
Alcanos/farmacologia
Alcenos/química
Alcenos/isolamento & purificação
Alcenos/farmacologia
Animais
Compostos de Bifenilo/antagonistas & inibidores
Compostos de Bifenilo/química
Células CHO
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Ensaio Cometa
Cricetulus
DNA/efeitos dos fármacos
Depuradores de Radicais Livres/química
Depuradores de Radicais Livres/isolamento & purificação
Fontes Termais
Seres Humanos
Hidrocarbonetos Aromáticos/química
Hidrocarbonetos Aromáticos/isolamento & purificação
Peróxido de Hidrogênio/antagonistas & inibidores
Peróxido de Hidrogênio/química
Itália
Espectroscopia de Ressonância Magnética
Camundongos
Terapia por Lama
Fenóis/química
Fenóis/isolamento & purificação
Picratos/antagonistas & inibidores
Picratos/química
Terpenos/química
Terpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Alkanes); 0 (Alkenes); 0 (Biphenyl Compounds); 0 (Free Radical Scavengers); 0 (Hydrocarbons, Aromatic); 0 (Phenols); 0 (Picrates); 0 (Terpenes); 9007-49-2 (DNA); BBX060AN9V (Hydrogen Peroxide); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE


  2 / 1003 MEDLINE  
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[PMID]:27749217
[Au] Autor:Caso F; Costa L; Del Puente A; Sorbo D; Balestrieri U; Peluso R; Scarpa R
[Ad] Endereço:Rheumatology Unit, Department of Clinical Medicine and Surgery, University Federico II, Naples, Italy.
[Ti] Título:Clinical effects of mud-bath therapy and oral glucosamine sulfate after 6 months of discontinuation in patients with knee osteoarthritis: results from a randomised, controlled, crossover study.
[So] Source:Clin Exp Rheumatol;35(1):169, 2017 Jan-Feb.
[Is] ISSN:0392-856X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Mh] Termos MeSH primário: Glucosamina/uso terapêutico
Terapia por Lama
Osteoartrite do Joelho/terapia
[Mh] Termos MeSH secundário: Estudos Cross-Over
Seguimentos
Seres Humanos
Osteoartrite do Joelho/tratamento farmacológico
Resultado do Tratamento
Suspensão de Tratamento
[Pt] Tipo de publicação:LETTER; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
N08U5BOQ1K (Glucosamine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170923
[Lr] Data última revisão:
170923
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161018
[St] Status:MEDLINE


  3 / 1003 MEDLINE  
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[PMID]:27723261
[Au] Autor:Ciani O; Pascarelli NA; Giannitti C; Galeazzi M; Meregaglia M; Fattore G; Fioravanti A
[Ad] Endereço:CeRGAS, Centre for Research on Health and Social Care Management, Bocconi University, Milan, Italy, and University of Exeter Medical School, Exeter, UK.
[Ti] Título:Mud-Bath Therapy in Addition to Usual Care in Bilateral Knee Osteoarthritis: An Economic Evaluation Alongside a Randomized Controlled Trial.
[So] Source:Arthritis Care Res (Hoboken);69(7):966-972, 2017 Jul.
[Is] ISSN:2151-4658
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To perform a cost-effectiveness analysis of mud-bath therapy (MBT) in addition to usual treatment compared to usual treatment alone in patients with bilateral knee osteoarthritis (OA). METHODS: An economic evaluation alongside a randomized controlled trial was conducted. Patients were randomly assigned to receive either a 2-week cycle of MBT in addition to their usual treatment or to continue routine care alone. The EuroQol 5-domain questionnaire was administered at baseline, 2 weeks, and at 3, 6, 9, and 12 months. Direct health care resource consumption data up until 12 months were derived from a daily diary given to patients and returned at prescheduled followup visits. RESULTS: A total of 103 patients were included (n = 53 for MBT patients; n = 50 for controls). Overall, patients in the MBT group accrued mean ± SD 0.835 ± 0.10 quality-adjusted life years (QALYs) compared to 0.753 ± 0.11 in the control group (P < 0.001). Average direct costs per patient (€303 versus €975; P < 0.001) were higher in the control group, primarily because of hospitalization for total knee replacement and use of intraarticular hyaluronic acid. Bootstrapping replications of costs and QALY sample distributions consistently indicated that the MBT therapy combined with standard therapy represents a dominant strategy as compared with standard therapy alone. The probability of MBT being cost-effective at standard cost-effectiveness thresholds (e.g., €20,000/QALY) is 100%. CONCLUSION: The results of this cost-effectiveness analysis support the use of MBT as midterm complementary therapy in the management of knee OA.
[Mh] Termos MeSH primário: Análise Custo-Benefício
Terapia por Lama/economia
Osteoartrite do Joelho/economia
Osteoartrite do Joelho/terapia
Assistência ao Paciente/economia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Terapia Combinada/economia
Terapia Combinada/métodos
Análise Custo-Benefício/métodos
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Terapia por Lama/métodos
Osteoartrite do Joelho/diagnóstico
Assistência ao Paciente/métodos
Estudos Prospectivos
Método Simples-Cego
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161011
[St] Status:MEDLINE
[do] DOI:10.1002/acr.23116


  4 / 1003 MEDLINE  
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[PMID]:27714506
[Au] Autor:Özkuk K; Gürdal H; Karagülle M; Barut Y; Eröksüz R; Karagülle MZ
[Ad] Endereço:Department of Medical Ecology and Hydroclimatology, Izzet Baysal Physical Medicine and Rehabilitation Training and Research Hospital, 14020, Bolu, Turkey. kagan_64@hotmail.com.
[Ti] Título:Balneological outpatient treatment for patients with knee osteoarthritis; an effective non-drug therapy option in daily routine?
[So] Source:Int J Biometeorol;61(4):719-728, 2017 Apr.
[Is] ISSN:1432-1254
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study aims to compare the effects of balneological treatments applied at consecutive and intermittent sessions without interfering with their daily routine in patients with knee osteoarthritis. This is a randomized, controlled, single-blind clinical trial. Fifty patients diagnosed with knee osteoarthritis were included. The patients were divided into two groups. All patients were given a total of ten sessions of balneological treatment consisting of hydrotherapy and mud pack therapy. Group 1 received consecutive treatment for 2 weeks, while group 2 received intermittent treatment for 5 weeks. Local peloid packs at 45 °C were applied for 20 min, after a tap water (38 °C) bath. Evaluations were conducted before, after treatment, and at 12th week of post-treatment by Pain (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Short Form-36 (SF-36). Both balneological treatment regimens of knee osteoarthritis had statistically significant clinical effects as well as effects on the quality of life. Patients' well-being continued at 3 months, except for joint stiffness (WOMAC), role-emotional (SF-36), and vitality (SF-36) in group 1 and for mental health (SF-36) in both groups. Both patient groups had improved compared to baseline. However, at 3 months after the treatment, the well-being of group 2 was unable to be maintained in terms of role-physical (SF-36) parameter, while the well-being of group 1 was unable to be maintained in terms of pain, WOMAC (pain, physical functions, total), and SF-36 (physical functioning, role-physical, pain, role-emotional, and mental health) variables, compared to data obtained immediately after treatment. Our study suggests that traditional and intermittent balneological therapies have similar efficacy in patients with knee osteoarthritis.
[Mh] Termos MeSH primário: Hidroterapia
Terapia por Lama
Osteoartrite do Joelho/terapia
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Pacientes Ambulatoriais
Qualidade de Vida
Método Simples-Cego
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161008
[St] Status:MEDLINE
[do] DOI:10.1007/s00484-016-1250-8


  5 / 1003 MEDLINE  
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[PMID]:27500681
[Au] Autor:Adilov VB; Lvova NV; Morozova EY
[Ad] Endereço:State autonomous health facility 'Moscow Research and Practical Centre for Medical Rehabilitation, Restorative and Sports Medicine', Moscow Health Department, Moscow, Russia.
[Ti] Título:[The natural therapeutic resources of Russia: the topical problems].
[Ti] Título:Prirodnye lechebnye resursy Rossii: aktual'nye problemy..
[So] Source:Vopr Kurortol Fizioter Lech Fiz Kult;93(4):60-65, 2016.
[Is] ISSN:0042-8787
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Mineral water, therapeutic peloids, favorable landscape and climatic conditions make up the main basis for the creation and development of the health resort business. Mineral water and therapeutic peloids are mineral resources, their prospecting, discovery, exploration and stock assessment of the responsibility of the Geological Survey of the country while the exploration and practical exploitation of the natural medicinal resources is the prerogative of the users of subsurface resources. At present, there are over 1200 deposits of mineral waters as well as more than 260 sources of therapeutic peloids at the territory of the Russian Federation; the include almost all hydrochemical species and types known and exploited in the world's practice The overall picture of the distribution of the potential and developed deposits of mineral waters and therapeutic peloids of the territory of this country is highly non-uniform and depends on the extent of the economic development of different regions, their geographical and climatic conditions as well as the state and availability of the spa and health resort infrastructure. The natural therapeutic resources, territories suitable for the organization and realization of health promoting activities, setting up new spa and health resort facilities are highly vulnerable to any external impact. We possess the scientifically grounded and practice-proven methods for the search, prospecting, practical development, and medical utilization of various natural therapeutic resources as well as technologies for their conservation, restoration, and protection from damages and overexploitation. The rational use and development of the territories promising for the extension of health resort business imply the necessity of the systemic approach in a consistent stage by stage manner based of the reliable prognoses.
[Mh] Termos MeSH primário: Estâncias para Tratamento de Saúde
Reabilitação
[Mh] Termos MeSH secundário: Seres Humanos
Águas Minerais/uso terapêutico
Terapia por Lama
Federação Russa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mineral Waters)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160809
[St] Status:MEDLINE
[do] DOI:10.17116/kurort2016460-65


  6 / 1003 MEDLINE  
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[PMID]:27500680
[Au] Autor:Efimenko NV; Abramtsova AV; Kaysinova AS
[Ad] Endereço:Pyatigorsk state scientific and research institute of balneology of FMBA Russia, Pyatigorsk, Russia.
[Ti] Título:[The investigation of immunological effects of the new balneotherapeutic preparation glinofir used for the treatment of adjuvant arthritis].
[Ti] Título:Izuchenie immunologicheskikh effektov novogo bal'neologicheskogo sredstva glinofir pri ad''yuvantnom artrite..
[So] Source:Vopr Kurortol Fizioter Lech Fiz Kult;93(4):56-59, 2016.
[Is] ISSN:0042-8787
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:AIM: The objective of the present study was to investigate the influence of a course of application of the modified natural factors on the immunological mechanisms of regulation under experimental conditions with special reference to the application of the natural yellow clay, the clay from the Novo-Pyatigorsk quarry (the lake Tambokan) and of the new balneotherapeutic preparation glinofir based on this modified clay and designed for the treatment of adjuvant arthritis (AA). MATERIAL AND METHODS: The study of anti-inflammatory activity of the externally applied balneomedicines was carried out with the use of an animal model of adjuvant arthritis. The course of applications started 3 days prior to the initiation of AA and was terminated on the 24th day of the experimental disease. The action of three balneotherapeutic preparations (Tambukan mud, yellow clay, and modified clay in the form of Glinofir) was compared after they were heated to 42 °C and applied to the animals' limbs for 15-20 minutes every second and third days. The experiments were performed on Wistar rats (n=59) divided into five groups. Group 1 was comprised of 9 healthy animals that served as controls. The animals of group 2 (n=10) presented with untreated experimentally-induced adjuvant arthritis, those of Group 3 (n=10) had model AA treated by a course of application of the Tambukan mud. The animals of group 4 (n=10) had model AA and were treated by the application of the yellow clay and those of Group 5 (n=10) with model of AA received a course of application of the modified clay. RESULTS: On day 37 after the induction of adjuvant arthritis, the animals developed leukocytosis (white blood cell count in the blood was 1.5 times higher than in the control group) and alterations in the composition of the lymphocyte population, viz. B-lymphocytes increased 2-2.5 times (p<0,02) while T-lymphocytes decreased (p<0,05). A course of glinofir application contributed to the restoration of the T-cytotoxic cell population (p<0,2) and influenced the regulation of pathological immune complexes (PIC) as confirmed the negative correlation between the PIC level and the absolute number of T-cytotoxic cells (r=-0,8, p<0,01). The chronic stage of AA was associated with a two-fold increase in the absorptive capacity of neutrophils. The treatment with the Tambukan mud and glinofir restored the phagocytic function of neutrophils and simultaneously reduced the blood leukocyte reaction. CONCLUSION: The anti-inflammatory action of the Tambukan mud and glinofir manifests itself in the unidirectional changes of dynamics of the characteristics of cellular and humoral immunity.
[Mh] Termos MeSH primário: Artrite Experimental/terapia
Produtos Biológicos/uso terapêutico
Terapia por Lama
[Mh] Termos MeSH secundário: Animais
Artrite Experimental/patologia
Artrite Experimental/reabilitação
Seres Humanos
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biological Products)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160809
[St] Status:MEDLINE
[do] DOI:10.17116/kurort2016456-59


  7 / 1003 MEDLINE  
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[PMID]:27228651
[Au] Autor:Pascarelli NA; Cheleschi S; Bacaro G; Guidelli GM; Galeazzi M; Fioravanti A
[Ti] Título:Effect of Mud-Bath Therapy on Serum Biomarkers in Patients with Knee Osteoarthritis: Results from a Randomized Controlled Trial.
[So] Source:Isr Med Assoc J;18(3-4):232-7, 2016 Mar-Apr.
[Is] ISSN:1565-1088
[Cp] País de publicação:Israel
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Balneotherapy is one of the most commonly used non-pharmacological approaches for osteoarthritis (OA). Recent data indicate that some biomarkers could be useful to predict OA progression and to assess therapeutic response. OBJECTIVES: To evaluate the effects of mud-bath therapy on serum biomarkers in patients with knee OA. METHODS: The study group comprised 103 patients with primary symptomatic bilateral knee OA who were randomly assigned to receive a cycle of mud-bath therapy over a period of 2 weeks or to continue their standard therapy alone. Clinical and biochemical parameters were assessed at baseline and after 2 weeks. Clinical assessments included global pain score on a visual analogue scale (VAS) and the Western Ontario and McMaster Universities Index (WOMAC) subscores for knee OA. Cartilage oligomeric matrix protein (COMP), C-terminal cross-linked telopeptide type II collagen (CTX-II), myeloperoxidase (MPO) and high sensitivity C-reactive protein (hsCRP) serum levels were assessed by ELISA. RESULTS: At the end of mud-bath therapy we observed a statistically significant improvement in VAS and WOMAC subscores. Serum levels of COMP, MPO and hsCRP did not show any significant modification in either group, while a significant increase (P < 0.001) in CTX-II serum levels was observed in the mud-bath group after the treatment. CONCLUSIONS: A cycle of mud-bath therapy added to the usual treatment had a beneficial effect on pain and function in patients with knee OA. The evaluation of serum biomarkers showed a significant increase of CTX-II only, perhaps due to an increase of cartilage turnover induced by thermal stress.
[Mh] Termos MeSH primário: Proteína C-Reativa/análise
Proteína de Matriz Oligomérica de Cartilagem/sangue
Terapia por Lama/métodos
Osteoartrite do Joelho
Peroxidase/sangue
[Mh] Termos MeSH secundário: Idoso
Biomarcadores/sangue
Progressão da Doença
Seres Humanos
Masculino
Meia-Idade
Osteoartrite do Joelho/diagnóstico
Osteoartrite do Joelho/imunologia
Osteoartrite do Joelho/terapia
Medição da Dor/métodos
Prognóstico
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biomarkers); 0 (Cartilage Oligomeric Matrix Protein); 9007-41-4 (C-Reactive Protein); EC 1.11.1.7 (Peroxidase)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:160527
[Lr] Data última revisão:
160527
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160528
[St] Status:MEDLINE


  8 / 1003 MEDLINE  
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[PMID]:27050908
[Au] Autor:Peluso R; Caso F; Costa L; Sorbo D; Carraturo N; Di Minno MN; Carraturo F; Oriente A; Balestrieri U; Minicucci A; Del Puente A; Scarpa R
[Ad] Endereço:Rheumatology Unit, Department of Clinical Medicine and Surgery, University Federico II, Naples, Italy.
[Ti] Título:Mud-bath therapy and oral glucosamine sulfate in patients with knee osteoarthritis: a randomized, controlled, crossover study.
[So] Source:Clin Exp Rheumatol;34(4):618-24, 2016 Jul-Aug.
[Is] ISSN:0392-856X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To evaluate the efficacy and safety of combined treatment of mud-bath therapy and glucosamine crystalline sulfate (GlcN-S) in patients with knee osteoarthritis (OA). METHODS: This study was a randomised, controlled, crossover investigation. Patients were randomly assigned (1:1) by the investigators to two groups, named group 1 and 2. Group 1 included twenty-three patients receiving oral GlcN-S treatment from the beginning of the study (T0) to the end of the 3rd month of treatment (T3) and a combined treatment of both mud-bath therapy and GlcN-S from T3 to the end of the study at six months (T6). Group 2 included twenty-two patients receiving a combined treatment of both mud-bath therapy and GlcN-S from T0 to T3 and that discontinued mud-bath therapy, receiving GlcN-S treatment alone, from T3 to T6. Primary endpoints of the study consisted of evaluating OA severity and activity at baseline and at follow-up visits. RESULTS: All 45 patients, eligible for the study, completed the period of the crossover. In group 1, no significant difference was shown in the comparison from T0 to T3, while from T3 to T6 most variables were significantly improved. In group 2, instead, the comparison between T0 and T3 showed a significant difference in different parameters. When comparing T3 and T6, despite an improvement of all the variables, no significant difference was shown. CONCLUSIONS: The association of GlcN-S and mud-bath therapy has a positive and safe role in improving pain, function and quality of life in knee OA patients.
[Mh] Termos MeSH primário: Artralgia/terapia
Glucosamina/administração & dosagem
Articulação do Joelho/efeitos dos fármacos
Terapia por Lama
Osteoartrite do Joelho/terapia
[Mh] Termos MeSH secundário: Administração Oral
Idoso
Idoso de 80 Anos ou mais
Artralgia/diagnóstico
Artralgia/fisiopatologia
Fenômenos Biomecânicos
Terapia Combinada
Estudos Cross-Over
Feminino
Seres Humanos
Itália
Articulação do Joelho/fisiopatologia
Masculino
Meia-Idade
Osteoartrite do Joelho/diagnóstico
Osteoartrite do Joelho/fisiopatologia
Medição da Dor
Qualidade de Vida
Recuperação de Função Fisiológica
Índice de Gravidade de Doença
Inquéritos e Questionários
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
N08U5BOQ1K (Glucosamine)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:170112
[Lr] Data última revisão:
170112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160407
[St] Status:MEDLINE


  9 / 1003 MEDLINE  
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[PMID]:26743034
[Au] Autor:Morrison KD; Misra R; Williams LB
[Ad] Endereço:Biosciences and Biotechnology Division, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
[Ti] Título:Unearthing the Antibacterial Mechanism of Medicinal Clay: A Geochemical Approach to Combating Antibiotic Resistance.
[So] Source:Sci Rep;6:19043, 2016 Jan 08.
[Is] ISSN:2045-2322
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Natural antibacterial clays, when hydrated and applied topically, kill human pathogens including antibiotic resistant strains proliferating worldwide. Only certain clays are bactericidal; those containing soluble reduced metals and expandable clay minerals that absorb cations, providing a capacity for extended metal release and production of toxic hydroxyl radicals. Here we show the critical antibacterial components are soluble Fe(2+) and Al(3+) that synergistically attack multiple cellular systems in pathogens normally growth-limited by Fe supply. This geochemical process is more effective than metal solutions alone and provides an alternative antibacterial strategy to traditional antibiotics. Advanced bioimaging methods and genetic show that Al(3+) misfolds cell membrane proteins, while Fe(2+) evokes membrane oxidation and enters the cytoplasm inflicting hydroxyl radical attack on intracellular proteins and DNA. The lethal reaction precipitates Fe(3+)-oxides as biomolecular damage proceeds. Discovery of this bactericidal mechanism demonstrated by natural clays should guide designs of new mineral-based antibacterial agents.
[Mh] Termos MeSH primário: Silicatos de Alumínio/farmacologia
Alumínio/farmacologia
Antibacterianos/farmacologia
Farmacorresistência Bacteriana/efeitos dos fármacos
Proteínas de Escherichia coli/antagonistas & inibidores
Ferro/farmacologia
[Mh] Termos MeSH secundário: Alumínio/química
Silicatos de Alumínio/química
Antibacterianos/química
Cátions Bivalentes
Farmacorresistência Bacteriana/genética
Escherichia coli/efeitos dos fármacos
Escherichia coli/genética
Escherichia coli/crescimento & desenvolvimento
Proteínas de Escherichia coli/química
Proteínas de Escherichia coli/genética
Expressão Gênica
Seres Humanos
Peróxido de Hidrogênio/química
Peróxido de Hidrogênio/metabolismo
Concentração de Íons de Hidrogênio
Radical Hidroxila/química
Radical Hidroxila/metabolismo
Ferro/química
Proteínas de Membrana/antagonistas & inibidores
Proteínas de Membrana/química
Proteínas de Membrana/genética
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Staphylococcus aureus Resistente à Meticilina/genética
Staphylococcus aureus Resistente à Meticilina/crescimento & desenvolvimento
Testes de Sensibilidade Microbiana
Terapia por Lama/métodos
Oxirredução
Dobramento de Proteína/efeitos dos fármacos
Pseudomonas aeruginosa/efeitos dos fármacos
Pseudomonas aeruginosa/genética
Pseudomonas aeruginosa/crescimento & desenvolvimento
Salmonella typhimurium/efeitos dos fármacos
Salmonella typhimurium/genética
Salmonella typhimurium/crescimento & desenvolvimento
Staphylococcus epidermidis/efeitos dos fármacos
Staphylococcus epidermidis/genética
Staphylococcus epidermidis/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Aluminum Silicates); 0 (Anti-Bacterial Agents); 0 (Cations, Divalent); 0 (Escherichia coli Proteins); 0 (Membrane Proteins); 1302-87-0 (clay); 3352-57-6 (Hydroxyl Radical); BBX060AN9V (Hydrogen Peroxide); CPD4NFA903 (Aluminum); E1UOL152H7 (Iron)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160109
[St] Status:MEDLINE
[do] DOI:10.1038/srep19043


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[PMID]:26675542
[Au] Autor:Karpinska M; Mnich K; Kapala J; Bielawska A; Kulesza G; Mnich S
[Ad] Endereço:Medical University of Bialystok, Department of Biophysics, Mickiewicza 2A, 15-222 Bialystok, Poland. Electronic address: karpm@umb.edu.pl.
[Ti] Título:Radioactivity of peat mud used in therapy.
[So] Source:J Environ Radioact;152:97-100, 2016 Feb.
[Is] ISSN:1879-1700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of the study was to determine the contents of natural and artificial isotopes in peat mud and to estimate the radiation dose absorbed via skin in patients during standard peat mud treatment. The analysis included 37 samples collected from 8 spas in Poland. The measurements of isotope concentration activity were conducted with the use of gamma spectrometry methods. The skin dose in a standard peat mud bath therapy is approximately 300 nSv. The effective dose of such therapy is considered to be 22 nSv. The doses absorbed during peat mud therapy are 5 orders of magnitude lower than effective annual dose absorbed from the natural radiation background by a statistical Pole (3.5 mSv). Neither therapeutic nor harmful effect is probable in case of such a small dose of ionising radiation.
[Mh] Termos MeSH primário: Dose de Radiação
Monitoramento de Radiação
Radioatividade
Absorção Cutânea
Solo/química
[Mh] Termos MeSH secundário: Radiação de Fundo
Sedimentos Geológicos/química
Seres Humanos
Terapia por Lama
Polônia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Soil)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151218
[St] Status:MEDLINE



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