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[PMID]:28277805
[Au] Autor:Zwiers C; van Kamp I; Oepkes D; Lopriore E
[Ad] Endereço:a Department of Obstetrics , Leiden University Medical Center , Leiden , the Netherlands.
[Ti] Título:Intrauterine transfusion and non-invasive treatment options for hemolytic disease of the fetus and newborn - review on current management and outcome.
[So] Source:Expert Rev Hematol;10(4):337-344, 2017 Apr.
[Is] ISSN:1747-4094
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Hemolytic disease of the fetus and newborn (HDFN) remains a serious pregnancy complication which can lead to severe fetal anemia, hydrops and perinatal death. Areas covered: This review focusses on the current prenatal management, treatment with intrauterine transfusion (IUT) and promising non-invasive treatment options for HDFN. Expert commentary: IUTs are the cornerstone in prenatal management of HDFN and have significantly improved perinatal outcome in the past decades. IUT is now a relatively safe procedure, however the risk of complications is still high when performed early in the second trimester. Non-invasive management using intravenous immunoglobulin may be a safe alternative and requires further investigation.
[Mh] Termos MeSH primário: Anemia Hemolítica/terapia
Transfusão de Sangue Intrauterina
Terapia Combinada
Doenças Fetais/terapia
Terapias Fetais
Hemólise
Doenças do Recém-Nascido/terapia
[Mh] Termos MeSH secundário: Anemia Hemolítica/diagnóstico
Anemia Hemolítica/etiologia
Transfusão de Sangue Intrauterina/efeitos adversos
Transfusão de Sangue Intrauterina/métodos
Terapia Combinada/efeitos adversos
Terapia Combinada/métodos
Gerenciamento Clínico
Feminino
Doenças Fetais/diagnóstico
Doenças Fetais/etiologia
Terapias Fetais/efeitos adversos
Terapias Fetais/métodos
Seres Humanos
Recém-Nascido
Doenças do Recém-Nascido/diagnóstico
Doenças do Recém-Nascido/etiologia
Gravidez
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170518
[Lr] Data última revisão:
170518
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.1080/17474086.2017.1305265


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[PMID]:27914652
[Au] Autor:Nassr AA; Shamshirsaz AA; Belfort MA; Espinoza J
[Ad] Endereço:Department of Obstetrics and Gynecology, Baylor College of Medicine and Texas Children's Fetal Center, Houston, TX, USA; Department of Obstetrics and Gynecology, Women's Health Hospital, Assiut University, Egypt. Electronic address: Ahmed.nassr@bcm.com.
[Ti] Título:Spontaneous resolution of mirror syndrome following fetal interventions for fetal anemia as a consequence of twin to twin transfusion syndrome.
[So] Source:Eur J Obstet Gynecol Reprod Biol;208:110-111, 2017 Jan.
[Is] ISSN:1872-7654
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Mh] Termos MeSH primário: Edema/etiologia
Ruptura Prematura de Membranas Fetais/etiologia
Transfusão Feto-Fetal/fisiopatologia
Hidropisia Fetal/etiologia
Poli-Hidrâmnios/etiologia
Complicações na Gravidez/etiologia
[Mh] Termos MeSH secundário: Adulto
Transfusão de Sangue Intrauterina
Terapia Combinada
Edema/fisiopatologia
Edema/prevenção & controle
Feminino
Transfusão Feto-Fetal/diagnóstico por imagem
Transfusão Feto-Fetal/cirurgia
Transfusão Feto-Fetal/terapia
Hospitais Pediátricos
Seres Humanos
Hidropisia Fetal/diagnóstico por imagem
Lactente Extremamente Prematuro
Recém-Nascido
Unidades de Terapia Intensiva Neonatal
Fotocoagulação
Nascimento Vivo
Masculino
Poli-Hidrâmnios/diagnóstico por imagem
Gravidez
Complicações na Gravidez/fisiopatologia
Complicações na Gravidez/prevenção & controle
Texas
Resultado do Tratamento
Ultrassonografia Pré-Natal
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170419
[Lr] Data última revisão:
170419
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161205
[St] Status:MEDLINE


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[PMID]:27807866
[Au] Autor:Al-Jada NA
[Ad] Endereço:Department of Medical Laboratory and Forensic Medicine, Division of Blood Bank, Jordan University Hospital, Amman, Jordan.
[Ti] Título:A Jordanian family with three sisters apparently homozygous for M and evidence for clinical significance of antibodies produced by M M individuals.
[So] Source:Transfusion;57(2):376-378, 2017 Feb.
[Is] ISSN:1537-2995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The rare M M phenotype is the result of a deletion of the coding regions of both GYPA and GYPB. Red blood cells (RBCs) of individuals homozygous for the rare M gene lack all MNS blood group antigens and have no glycophorin A or glycophorin B. This phenotype is extremely rare and only four families have been reported. CASE REPORT: A 28-year-old woman was referred for assessment of recurrent early neonatal deaths. She was found to be apparently homozygous for M . With the presence of two M M sisters as matched donors, an intrauterine transfusion was performed to treat fetal anemia due to a strong maternal atypical antibody. Twins were delivered and subsequently transfused with RBCs from the proposita and her M M sisters. CONCLUSION: This case reports the fifth family with members apparently homozygous for M and the second example of severe hemolytic disease of the fetus and newborn (HDFN) due to maternal antibodies produced by M M individuals. It also shows the importance of intensive monitoring and management of HDFN caused by alloantibodies to RBC antigens.
[Mh] Termos MeSH primário: Anemia
Transfusão de Sangue Intrauterina
Eritroblastose Fetal
Transfusão de Eritrócitos
Glicoforina/genética
Homozigoto
Sistema do Grupo Sanguíneo MNSs
[Mh] Termos MeSH secundário: Adulto
Anemia/sangue
Anemia/genética
Anemia/terapia
Sequência de Bases
Eritroblastose Fetal/sangue
Eritroblastose Fetal/genética
Eritroblastose Fetal/terapia
Feminino
Seres Humanos
Isoanticorpos/sangue
Jordânia
Sistema do Grupo Sanguíneo MNSs/sangue
Sistema do Grupo Sanguíneo MNSs/genética
Masculino
Gravidez
Deleção de Sequência
[Pt] Tipo de publicação:CASE REPORTS
[Nm] Nome de substância:
0 (GYPA protein, human); 0 (GYPB protein, human); 0 (Glycophorin); 0 (Isoantibodies); 0 (MNSs Blood-Group System)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161104
[St] Status:MEDLINE
[do] DOI:10.1111/trf.13899


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[PMID]:27664264
[Au] Autor:Wallace AH; Dalziel SR; Cowan BR; Young AA; Thornburg KL; Harding JE
[Ad] Endereço:Liggins Institute, University of Auckland, Auckland, New Zealand.
[Ti] Título:Long-term cardiovascular outcome following fetal anaemia and intrauterine transfusion: a cohort study.
[So] Source:Arch Dis Child;102(1):40-45, 2017 Jan.
[Is] ISSN:1468-2044
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To compare long-term cardiovascular outcomes in survivors of fetal anaemia and intrauterine transfusion with those of non-anaemic siblings. DESIGN: Retrospective cohort study. SETTING: Auckland, New Zealand. PARTICIPANTS: Adults who received intrauterine transfusion for anaemia due to rhesus disease (exposed) and their unexposed sibling(s). EXPOSURE: Fetal anaemia requiring intrauterine transfusion. MAIN OUTCOME MEASURES: Anthropometry, blood pressure, lipids, heart rate variability and cardiac MRI, including myocardial perfusion. RESULTS: Exposed participants (n=95) were younger than unexposed (n=92, mean±SD 33.7±9.3 vs 40.1±10.9 years) and born at earlier gestation (34.3±1.7 vs 39.5±2.1 weeks). Exposed participants had smaller left ventricular volumes (end-diastolic volume/body surface area, difference between adjusted means -6.1, 95% CI -9.7 to -2.4 mL/m ), increased relative left ventricular wall thickness (difference between adjusted means 0.007, 95% CI 0.001 to 0.012 mm.m /mL) and decreased myocardial perfusion at rest (ratio of geometric means 0.86, 95% CI 0.80 to 0.94). Exposed participants also had increased low frequency-to-high frequency ratio on assessment of heart rate variability (ratio of geometric means 1.53, 95% CI 1.04 to 2.25) and reduced high-density lipoprotein concentration (difference between adjusted means -0.12, 95% CI -0.24 to 0.00 mmol/L). CONCLUSIONS: This study provides the first evidence in humans that cardiovascular development is altered following exposure to fetal anaemia and intrauterine transfusion, with persistence of these changes into adulthood potentially indicating increased risk of cardiovascular disease. These findings are relevant to the long-term health of intrauterine transfusion recipients, and may potentially also have implications for adults born preterm who were exposed to anaemia at a similar postconceptual age.
[Mh] Termos MeSH primário: Anemia/terapia
Doenças Cardiovasculares/embriologia
Doenças Fetais/terapia
[Mh] Termos MeSH secundário: Adulto
Anemia/embriologia
Transfusão de Sangue Intrauterina
Feminino
Frequência Cardíaca/fisiologia
Seres Humanos
Estudos Longitudinais
Angiografia por Ressonância Magnética
Masculino
Projetos Piloto
Isoimunização Rh/terapia
Fatores de Risco
Volume Sistólico/fisiologia
Função Ventricular Esquerda/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160925
[St] Status:MEDLINE
[do] DOI:10.1136/archdischild-2016-310984


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[PMID]:27573913
[Au] Autor:Pecker LH; Guerrera MF; Loechelt B; Massaro A; Abraham AA; Fasano RM; Meier ER
[Ad] Endereço:Center for Cancer and Blood Disorders, Children's National Medical Center, Washington, District of Columbia.
[Ti] Título:Homozygous α-thalassemia: Challenges surrounding early identification, treatment, and cure.
[So] Source:Pediatr Blood Cancer;64(1):151-155, 2017 Jan.
[Is] ISSN:1545-5017
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The prognosis for homozygous α-thalassemia is changing. Prenatal diagnosis and intrauterine transfusions (IUT) reduce maternofetal morbidity and mortality; hematopoietic stem cell transplant (HSCT) is curative. Empiric evidence to support IUT and HSCT to treat homozygous α-thalassemia is lacking. The first case of curative HSCT for homozygous α-thalassemia was reported in 1997. Nearly 20 years later, five additional reports are published. We review the literature and report an institutional experience with three homozygous α-thalassemia patients. The first died shortly after birth. The second underwent HSCT after years of chronic transfusion therapy. The third benefited from IUT and HSCT. These cases exemplify the varied outcomes associated with this condition.
[Mh] Termos MeSH primário: Transfusão de Sangue
Transplante de Células-Tronco Hematopoéticas
Talassemia alfa/terapia
[Mh] Termos MeSH secundário: Transfusão de Sangue Intrauterina
Feminino
Seres Humanos
Recém-Nascido
Masculino
Gravidez
Prognóstico
Talassemia alfa/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170620
[Lr] Data última revisão:
170620
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160831
[St] Status:MEDLINE
[do] DOI:10.1002/pbc.26163


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[PMID]:27174184
[Au] Autor:Bellussi F; Perolo A; Ghi T; Youssef A; Pilu G; Simonazzi G
[Ad] Endereço:Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
[Ti] Título:Diagnosis of Severe Fetomaternal Hemorrhage with Fetal Cerebral Doppler: Case Series and Systematic Review.
[So] Source:Fetal Diagn Ther;41(1):1-7, 2017.
[Is] ISSN:1421-9964
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To analyze the role of middle cerebral artery (MCA) peak systolic velocity (PSV) in the prediction of severe fetomaternal hemorrhage (FMH) and to compare it with standard biophysical assessment. DATA SOURCES: Retrospective review of cases of FMH seen in our unit and systematic review of the literature. RESULTS: We followed the MOOSE guidelines to review the literature. From 838 articles, 16 were selected. In total, 35 women, including 3 cases from our center and 32 obtained from the literature search were included. Diagnosis of FMH was always confirmed by laboratory tests. Patients were seen at 31 ± 5 weeks' gestation (range 16-39) and the most frequent indication for referral was decreased perception of fetal movements. Cardiotocography (CTG) upon admission was sinusoidal in 18 cases, nonreactive in 6, decelerative in 2 and tachycardic in one. MCA-PSV was abnormal in all cases but one. There were 2 perinatal deaths. The mean hemoglobin concentration at birth or at intrauterine transfusion was 4.8 ± 1.9 g/dl. DISCUSSION: The most accurate predictor of FMH was fetal MCA-PSV. CTG was always abnormal but the pattern was frequently nonspecific. We suggest including fetal cerebral Doppler in the evaluation of patients with decreased fetal movements, particularly in those cases with ambiguous results of biophysical testing.
[Mh] Termos MeSH primário: Transfusão Feto-Materna/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Transfusão de Sangue Intrauterina
Feminino
Citometria de Fluxo
Seres Humanos
Gravidez
Estudos Retrospectivos
Ultrassonografia Doppler
Ultrassonografia Pré-Natal
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170227
[Lr] Data última revisão:
170227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160514
[St] Status:MEDLINE
[do] DOI:10.1159/000446109


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[PMID]:28361594
[Au] Autor:Lee HH; Mak AS; Kou KO; Poon CF; Wong WS; Chiu KH; Au PK; Chan KY; Kan AS; Tang MH; Leung KY
[Ad] Endereço:a Department of Obstetrics and Gynaecology , Queen Elizabeth Hospital , Hong Kong SAR , People's Republic of China.
[Ti] Título:An Unusual Hydrops Fetalis Associated with Compound Heterozygosity for Krüppel-like Factor 1 mutations.
[So] Source:Hemoglobin;40(6):431-434, 2016 Nov.
[Is] ISSN:1532-432X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Hydrops fetalis is commonly due to Hb Bart's (γ4) disease in South East Asia. Here, we report an unusual case of hydrops fetalis due to congenital dyserythropoietic anemia (CDA) associated with compound heterozygosity for Krüppel-like factor 1 (KLF1) gene mutations. Fetal cardiomegaly was first detected on routine mid-trimester scan in a pregnant woman with normal mean corpuscular volume (MCV) and Rhesus positive status. The fetus subsequently developed hydrops fetalis, and cordocentesis showed severe fetal anemia with a hemoglobin (Hb) level of 3.4 g/dL. Common causes of fetal anemia including Hb Bart's disease, parvovirus infection, and red cell antibodies were excluded. In view of the marked increase in erythroblasts at various stages of erythropoiesis, the diagnosis of CDA was suspected. We screened the couple for previously reported KLF1 gene mutations, showing that the mother was heterozygous for the c.525_526insCGGCGCC, p.Gly176Argfs*179 mutation, and her husband heterozygous for c.1012C>A, p.Pro338Thr mutation. The fetus was a compound heterozygote for these two KLF1 mutations. After counseling, repeated intrauterine transfusions were given at 27, 29, and 34 weeks' gestation; the hydrops fetalis was resolved. The baby was delivered at 34 weeks' gestation and required monthly blood transfusions but was otherwise thriving. Bone marrow aspiration at 10 months of age showed the features of ineffective erythropoiesis, compatible with CDA. In conclusion, hydrops fetalis can rarely be due to CDA associated with a compound heterozygous mutation for KLF1 gene mutations, and be managed by repeated intrauterine transfusions. Our present report adds to the wide clinical spectrum of KLF1 mutations.
[Mh] Termos MeSH primário: Anemia Diseritropoética Congênita/diagnóstico
Anemia Diseritropoética Congênita/genética
Heterozigoto
Hidropisia Fetal/genética
Fatores de Transcrição Kruppel-Like/genética
Mutação
[Mh] Termos MeSH secundário: Adulto
Anemia Diseritropoética Congênita/etiologia
Anemia Diseritropoética Congênita/terapia
Transfusão de Sangue Intrauterina
Exame de Medula Óssea
Cordocentese
Feminino
Seres Humanos
Hidropisia Fetal/diagnóstico
Hidropisia Fetal/etiologia
Hidropisia Fetal/terapia
Lactente
Masculino
Gravidez
Diagnóstico Pré-Natal
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Kruppel-Like Transcription Factors); 0 (erythroid Kruppel-like factor)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE
[do] DOI:10.1080/03630269.2016.1267017


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[PMID]:27862048
[Au] Autor:Kreger EM; Singer ST; Witt RG; Sweeters N; Lianoglou B; Lal A; Mackenzie TC; Vichinsky E
[Ad] Endereço:The Department of Surgery, University of California, San Francisco, CA, USA.
[Ti] Título:Favorable outcomes after in utero transfusion in fetuses with alpha thalassemia major: a case series and review of the literature.
[So] Source:Prenat Diagn;36(13):1242-1249, 2016 Dec.
[Is] ISSN:1097-0223
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Alpha thalassemia major (ATM) is often fatal in utero due to severe hydrops fetalis. Although in utero transfusions (IUTs) are increasingly used to allow fetal survival in ATM, prenatal and postnatal outcomes are not well described. METHODS: We retrospectively reviewed cases of ATM at our institution treated with consecutive IUT. Clinical records were reviewed for transfusion history, neurodevelopmental outcomes, anatomic abnormalities, survival to hematopoietic cell transplantation, and transfusion independence. A systematic review was performed, and additional reported cases are discussed. RESULTS: Three patients who underwent IUT for ATM were identified, and review of the literature revealed 17 reported cases. Of patients who received IUT, reported neurodevelopmental deficits occurred in 29% (4/14) and anatomic abnormalities in 55% (11/20). Four patients eventually underwent successful hematopoietic cell transplantation. Transfusion volumes were less than suggested guidelines for other causes of fetal anemia in 91.7% of the transfusions. CONCLUSION: This series demonstrates the potential for achieving full fetal development with normal neurologic outcomes in those affected by ATM. It provides support for continued patient and provider education about current benefits and risks of active prenatal therapy for fetuses with ATM, as well as continued research to optimize therapeutic strategies such as in utero transplantation. © 2016 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Transfusão de Sangue Intrauterina
Doenças Fetais/terapia
Resultado do Tratamento
Talassemia alfa/embriologia
Talassemia alfa/terapia
[Mh] Termos MeSH secundário: Transfusão de Sangue Intrauterina/efeitos adversos
Transfusão de Sangue Intrauterina/métodos
Feminino
Desenvolvimento Fetal
Seguimentos
Idade Gestacional
Transplante de Células-Tronco Hematopoéticas
Seres Humanos
Hidropisia Fetal/etiologia
Masculino
Transtornos do Neurodesenvolvimento/epidemiologia
Transtornos do Neurodesenvolvimento/etiologia
Gravidez
Resultado da Gravidez
Talassemia alfa/complicações
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161119
[St] Status:MEDLINE
[do] DOI:10.1002/pd.4966


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[PMID]:27723391
[Au] Autor:Fillon G; Heaton PA; Paul SP
[Ad] Endereço:Registrar in Paediatrics in the Department of Paediatrics, Yeovil District Hospital, Higher Kingston, Yeovil.
[Ti] Título:Severe late onset anaemia following intrauterine transfusion.
[So] Source:Br J Hosp Med (Lond);77(10):600-601, 2016 Oct.
[Is] ISSN:1750-8460
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Anemia Neonatal/terapia
Transfusão de Sangue Intrauterina
Hemólise
Isoimunização Rh/terapia
[Mh] Termos MeSH secundário: Anemia Neonatal/etiologia
Transfusão de Sangue
Doenças da Medula Óssea/etiologia
Feminino
Seres Humanos
Recém-Nascido
Gravidez
Isoimunização Rh/complicações
Índice de Gravidade de Doença
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161011
[St] Status:MEDLINE


  10 / 1430 MEDLINE  
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[PMID]:27664105
[Au] Autor:Adam S; Lombaard H
[Ad] Endereço:Department of Obstetrics and Gynaecology, University of Pretoria, Pretoria, South Africa.
[Ti] Título:Autologous intrauterine transfusion in a case of anti-U.
[So] Source:Transfusion;56(12):3029-3032, 2016 Dec.
[Is] ISSN:1537-2995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Minor red blood cell antibodies are becoming a more common cause of hemolytic disease of the newborn. Anti-U are a rare alloantibody found almost exclusively in people of black descent. There is limited experience to guide the management of pregnancies complicated by anti-U. Furthermore, there is often no suitable cross-matched blood available for transfusion of a patient with anti-U. CASE REPORT: A 21-year-old P0G1 presented at 25 weeks' gestation with D- disease in pregnancy. She had a significant indirect antiglobulin test titer of 512. Anti-U were identified and no suitable cross-matched blood was available. Maternal blood was prepared for autologous intrauterine fetal transfusion. Two such transfusions were performed. RESULTS: A healthy fetus delivered at 32 weeks that did not require phototherapy or an exchange transfusion. CONCLUSION: Autologous transfusion of prepared maternal blood provides a safe option for intrauterine fetal therapy in pregnancies complicated by rare alloantibodies.
[Mh] Termos MeSH primário: Transfusão de Sangue Intrauterina/métodos
Eritroblastose Fetal/terapia
Isoanticorpos/sangue
[Mh] Termos MeSH secundário: Grupo com Ancestrais do Continente Africano/genética
Eritroblastose Fetal/imunologia
Eritroblastose Fetal/prevenção & controle
Feminino
Idade Gestacional
Seres Humanos
Gravidez
Transplante Autólogo
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS
[Nm] Nome de substância:
0 (Isoantibodies)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160925
[St] Status:MEDLINE
[do] DOI:10.1111/trf.13806



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