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[PMID]: 29452655 [Au] Autor: Amici JM; Chaussade V [Ad] Endereço: Service de dermatologie, hôpital Saint-André, Bordeaux, France. Electronic address: jmamici@gmail.com. [Ti] Título: [How to optimize scarring in dermatologic surgery?] [Ti] Título: Optimisation de la cicatrisation en chirurgie dermatologique et gestions des aléas.. [So] Source: Ann Dermatol Venereol;143 Suppl 2:S20-S25, 2016 Dec. [Is] ISSN: 0151-9638 [Cp] País de publicação: France [La] Idioma: fre [Ab] Resumo: Scarring is the response elicited by the skin surface to injury and loss of tissue material. Wound healing takes place through a complex natural repair system consisting of vascular, inflammatory and proliferative phenomena, followed by a remodelling and cell apoptosis phase. This incredible repair system is inevitable, but sometimes unpredictable due to individual differences based on multiple factors. The scar is the objective criterion of a skin surgery, both for the patient and the dermsurgeon. It is therefore crucial to establish with the patient during the preoperative consultation, the size and positioning of the expected scar, taking into account the oncologic, anatomic and surgical constraints. Scars can ideally blend into normal skin, but may also give rise to various abnormalities. We can manage and prevent these abnormalities by mastering initial inflammation, that may induce hyperpigmentation and hypertrophy. Early massage using cortocosteroid topic or anti-inflammatory moisturizers may be effective. Random individual scarring may be minimized by a dynamic personalized accompanying scarring. [Mh] Termos MeSH primário: Cicatriz/fisiopatologia Procedimentos Cirúrgicos Dermatológicos/efeitos adversos [Mh] Termos MeSH secundário: Corticosteroides/administração & dosagem Anti-Inflamatórios/administração & dosagem Cicatriz/prevenção & controle Cicatriz Hipertrófica/fisiopatologia Cicatriz Hipertrófica/prevenção & controle Terapia Combinada Eritema/fisiopatologia Eritema/prevenção & controle Hiperpigmentação/fisiopatologia Hiperpigmentação/prevenção & controle Queloide/fisiopatologia Massagem Educação de Pacientes como Assunto Fatores de Risco Pele/fisiopatologia Transplante de Pele Protetores Solares/administração & dosagem Telangiectasia/fisiopatologia Telangiectasia/prevenção & controle Cicatrização/fisiologia [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Adrenal Cortex Hormones); 0 (Anti-Inflammatory Agents); 0 (Sunscreening Agents) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180302 [Lr] Data última revisão: 180302 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180218 [St] Status: MEDLINE

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[PMID]: 29443757 [Au] Autor: Deng C; Li H; Wei Z; Jin W; Nie K; Li S; Wu B; Wang D [Ad] Endereço: Department of Plastic Surgery, Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou, People's Republic of China. [Ti] Título: Various surgical techniques to create an aesthetic appearance at the donor site of anterolateral thigh free flaps based on the oblique branch: Twenty-one clinical case reports. [So] Source: Medicine (Baltimore);97(7):e9885, 2018 Feb. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: RATIONALE: Reducing the morbidity associated with anterolateral thigh (ALT) donor sites by performing aesthetic restoration has become a popular research topic. Various surgical techniques have been developed allowing for direct closure of the donor site. However, closure techniques for ALT donor sites based on the oblique branch have not been systematically reported. PATIENT CONCERNS: Data from 21 patients (18 males, 3 females) undergoing operative reconstruction with an ALT free flap between January 2016 and December 2016. The mean age of the participants was 42 years (range, 18-60 years). DIAGNOSES: The soft-tissue defects resulted from a traffic accident in 9 patients, a fall injury in 7 patients, a machinery injury in 3 patients, an electrical injury in 1 patient, and a burn scar in 1 patient. The wound areas ranged from 6 × 3.5 to 28 cm × 10 cm. INTERVENTIONS: Several surgical techniques, including the split skin paddle technique and utilization of an adjacent perforator flap or an ipsilateral groin flap, were utilized to facilitate direct closure of the ALT flap donor site. OUTCOMES: Of the 21 patients included in the study, the donor sites were directly sutured in 14 patients (8 of which required a split skin paddle technique). Four patients required an adjacent perforator flap, and 3 patients received an ipsilateral groin flap. The size of the adjacent perforator flaps ranged from 15 × 5 to 17 × 6 cm. The groin flaps ranged from 18 × 6 to 28 × 6 cm. All the flaps had excellent appearance and texture. A linear scar in the donor area was not conspicuous and achieved an aesthetic appearance. LESSONS: The ALT flap donor site based on the oblique branch pedicle can be directly closed without skin grafts through the use of several surgical techniques. [Mh] Termos MeSH primário: Retalhos de Tecido Biológico Procedimentos Cirúrgicos Reconstrutivos/métodos Transplante de Pele/métodos Lesões dos Tecidos Moles/cirurgia Coxa da Perna/cirurgia Sítio Doador de Transplante/cirurgia [Mh] Termos MeSH secundário: Adulto Feminino Seres Humanos Masculino Meia-Idade Retalho Perfurante Cirurgia Plástica/métodos Resultado do Tratamento Técnicas de Fechamento de Ferimentos [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180222 [Lr] Data última revisão: 180222 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180215 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000009885

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[PMID]: 29291276 [Au] Autor: Shields BE; Moye MS; Bayon R; Sperry SM; Wanat KA [Ad] Endereço: 1 Department of Dermatology, University of Wisconsin, Madison, Wisconsin, USA. [Ti] Título: A Hairy Situation: Laser Hair Removal after Oral Reconstruction. [So] Source: Ann Otol Rhinol Laryngol;127(3):205-208, 2018 Mar. [Is] ISSN: 1943-572X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: OBJECTIVES: To present a case series of 4 patients who underwent postoperative hair removal using the long-pulsed Alexandrite or Nd:YAG laser following intraoral cutaneous flap reconstruction. METHODS: Patients underwent epilation in dermatology clinic with long-pulsed Alexandrite or Nd:YAG lasers, spaced 8 weeks apart, until hair removal was achieved. RESULTS: All patients achieved improvement in hair removal regardless of initial flap donor site with significant improvement in quality of life and minimal side effects. CONCLUSIONS: The long-pulsed Alexandrite and Nd:YAG represent safe and effective treatment options to improve patient quality of life following intraoral flap repair following excision of malignancy. [Mh] Termos MeSH primário: Remoção de Cabelo/métodos Terapia a Laser Complicações Pós-Operatórias Qualidade de Vida Transplante de Pele/efeitos adversos Retalhos Cirúrgicos/efeitos adversos [Mh] Termos MeSH secundário: Adulto Idoso Berílio/uso terapêutico Carcinoma de Células Escamosas/patologia Carcinoma de Células Escamosas/cirurgia Feminino Seres Humanos Terapia a Laser/instrumentação Terapia a Laser/métodos Lasers Masculino Meia-Idade Neoplasias Bucais/patologia Neoplasias Bucais/cirurgia Procedimentos Cirúrgicos Bucais/efeitos adversos Procedimentos Cirúrgicos Bucais/métodos Complicações Pós-Operatórias/psicologia Complicações Pós-Operatórias/terapia Transplante de Pele/métodos Resultado do Tratamento [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Nm] Nome de substância: 0 (alexandrite); OW5102UV6N (Beryllium) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180221 [Lr] Data última revisão: 180221 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180102 [St] Status: MEDLINE [do] DOI: 10.1177/0003489417750930

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[PMID]: 28746254 [Au] Autor: Powell MR; Davies BW [Ad] Endereço: Department of Ophthalmology and Oculofacial Plastic and Reconstructive Surgery, Department of Ophthalmology, San Antonio Uniformed Services Health Education Consortium, San Antonio, Texas, U.S.A. [Ti] Título: Cicatricial Ectropion Secondary to Graft-Versus-Host Disease. [So] Source: Ophthal Plast Reconstr Surg;34(1):e22-e23, 2018 Jan/Feb. [Is] ISSN: 1537-2677 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Ocular complications of graft-versus-host disease are well documented. While skin changes due to graft-versus-host disease have been mentioned in the literature, cicatricial ectropion has not been previous reported. The authors present a case of a 31-year-old male with cicatricial ectropion secondary to graft-versus-host disease requiring treatment with a full thickness skin graft. [Mh] Termos MeSH primário: Cicatriz/complicações Ectrópio/etiologia Pálpebras/cirurgia Doença Enxerto-Hospedeiro/complicações [Mh] Termos MeSH secundário: Adulto Blefaroplastia Cicatriz/diagnóstico Cicatriz/cirurgia Ectrópio/diagnóstico Ectrópio/cirurgia Pálpebras/patologia Seres Humanos Masculino Transplante de Pele/métodos Transplante de Células-Tronco/efeitos adversos [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180219 [Lr] Data última revisão: 180219 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170727 [St] Status: MEDLINE [do] DOI: 10.1097/IOP.0000000000000973

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[PMID]: 29390534 [Au] Autor: Liu H; Song K; Zhang M; Dong X; Liu S; Wang Y [Ad] Endereço: Department of Plastic Surgery, Peking Union Medical College Hospital. [Ti] Título: Toe keloid after nail extraction treated with surgical excision: A case report. [So] Source: Medicine (Baltimore);96(51):e9373, 2017 Dec. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: RATIONALE: In this study, a case of toe keloid after nail extraction is presented, in which the keloids on both toes were resected by surgical excision. Keloids (from the Greek word meaning "crab's claw") are fibrous growths that extend beyond the original area of injury to involve the adjacent normal skin. In general, keloid tendencies appear to be regionally isolated to keloid-prone areas, such as the chest, ears, and deltoid regions, whereas the hands and feet are usually spared, which is why this case is meaningful. PATIENT CONCERNS: A 20-year-old Chinese man had paronychia on both halluxes when he was 16 years old. He underwent a nail extraction at the age of 17. The nails of both halluxes were removed by nail extraction. This operation was successful, and the postoperative course was uneventful. After 6 months, the scars of the nail extraction on both sides began to exhibit hyperplasia and became red and swollen with itching. Later, the scar expanded and eroded the tissue beyond the matrix unguis. The whole matrix unguis was destroyed, and the nails were distorted. The scars began to ulcerate after 2 years. The patient used potassium permanganate to clean his wounds, but the keloid scars did not improve. DIAGNOSES: The patient was diagnosed as toe keloid based on his history and symptoms. The biopsy result supported our diagnoses. INTERVENTIONS: The toe keloids were effectively cured by surgical excision and skin flap transplantation combined with postoperative irradiation and hyperbaric oxygen (HBO) treatment. OUTCOMES: No recurrence was detected during the period from 6 to 24 months of follow-up after the surgery. LESSONS: In this case, the trauma of the nail extraction was likely the key cause of the keloid. However, the patient was also predisposed to keloids, as we observed keloids on his chest. In general, keloid tendencies appear to be regionally isolated to keloid-prone areas such as the chest, ears, and deltoid regions, whereas the hands and feet are usually spared, which is why this case is meaningful. [Mh] Termos MeSH primário: Queloide/cirurgia Paroniquia/cirurgia Complicações Pós-Operatórias/cirurgia Dedos do Pé/cirurgia [Mh] Termos MeSH secundário: Seres Humanos Queloide/etiologia Masculino Transplante de Pele Adulto Jovem [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180214 [Lr] Data última revisão: 180214 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180203 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000009373

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[PMID]: 29328583 [Au] Autor: Jovic MS; Dimitrijevic MM; Dimitrijevic AM; Stojkovic GG [Ti] Título: Analysis of reconstructive methods in surgical treatment of nasal skin defects. [So] Source: Vojnosanit Pregl;73(8):723-7, 2016 Aug. [Is] ISSN: 0042-8450 [Cp] País de publicação: Serbia [La] Idioma: eng [Ab] Resumo: Background/Aim: Surgeons often face with the problem when selecting a reconstructive method for nasal skin defects. The aim of this study was to determine functional and aesthetic character-istics of different reconstructive methods used for skin defects in different regions of the nose. Methods: The study involved 44 patients with basocellular carcinoma in nasal area. The nasal skin was divided into four subunits: the tip, the alar lobules, the side-walls and the dorsum. The average skin defect size was 10 mm in diameter. Local flaps and full thickness skin grafts were used in the study. We analyzed the functional and esthetic results of dif-ferent reconstructive methods used for nasal defects in different regions of the nose 12 months after the surgery. Results: The study shows that different reconstructive methods produce dif-ferent functional and esthetic results in the same nasal subunits and that the same reconstructive method produces different re-sults in different nasal subunits. Conclusions: Estimation the postoperative functional and esthetic characteristics of different reconstructive methods is one of the basic preconditions of suc-cessful reconstruction. [Mh] Termos MeSH primário: Carcinoma Basocelular/cirurgia Neoplasias Nasais/cirurgia Rinoplastia/métodos [Mh] Termos MeSH secundário: Idoso Idoso de 80 Anos ou mais Estética Feminino Seres Humanos Masculino Meia-Idade Neoplasias Cutâneas/cirurgia Transplante de Pele Retalhos Cirúrgicos Resultado do Tratamento [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180213 [Lr] Data última revisão: 180213 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180113 [St] Status: MEDLINE [do] DOI: 10.2298/VSP140829052J

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[PMID]: 29288671 [Au] Autor: Zhang Y; Wang Y; Wu G; Zhang W; Wang X; Cai W; Zhang J; Han S; Li Y; Bai X; Shi J; Su L; Hu D [Ad] Endereço: Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, 710032, China. [Ti] Título: Prolonged skin grafts survival time by IFN-γ in allogeneic skin transplantation model during acute rejection through IFN-γ/STAT3/IDO pathway in epidermal layer. [So] Source: Biochem Biophys Res Commun;496(2):436-442, 2018 02 05. [Is] ISSN: 1090-2104 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Allogeneic skin transplantation is the life-saving therapy for multiple diseases, including extensive burn, large-scale trauma and certain post-surgical complications. However, acute rejection impedes clinical application of allogeneic skin transplantation. Although a lot of novel immunosuppressant drugs have been developed, there is still great need for ideal therapy with less complication and more therapeutic effects. Here, we found interferon gamma (IFN-γ) as an immunomodulatory cytokine prolonged the survival time of allografts from (8.50 ±â€¯1.517) days to (14.83 ±â€¯2.714) days at best. Indoleamine-2, 3-dioxygenase (IDO) has been proposed to play key roles in induction of immune tolerance. Using in vitro tissue culture and primary keratinocytes and fibroblasts, we investigated the regulatory effects of IFN-γ on the IDO expression. IFN-γ upregulated IDO expression through STAT3 phosphorylation and this upregulation was reduced by abolition of STAT3 phosphorylation through a STAT3 phosphorylation inhibitor. Interestingly, IFN-γ induced IDO expression predominately in epidermis rather than dermis. In consistent with these results, IFN-γ significantly triggered IDO expression in keratinocytes but not fibroblasts. Taken together, this suggests that IFN-γ might be a potential immunomodulatory drug in acute rejection and keratinocytes in epidermis may play a main role in immune tolerance after allogeneic skin transplantation. [Mh] Termos MeSH primário: Rejeição de Enxerto/prevenção & controle Sobrevivência de Enxerto Fatores Imunológicos/farmacologia Indolamina-Pirrol 2,3,-Dioxigenase/genética Interferon gama/farmacologia Fator de Transcrição STAT3/genética Transplante de Pele [Mh] Termos MeSH secundário: Doença Aguda Animais Derme/citologia Derme/efeitos dos fármacos Derme/imunologia Epiderme/citologia Epiderme/efeitos dos fármacos Epiderme/imunologia Fibroblastos/citologia Fibroblastos/efeitos dos fármacos Fibroblastos/imunologia Regulação da Expressão Gênica Rejeição de Enxerto/imunologia Rejeição de Enxerto/patologia Tolerância Imunológica/efeitos dos fármacos Indolamina-Pirrol 2,3,-Dioxigenase/imunologia Queratinócitos/citologia Queratinócitos/efeitos dos fármacos Queratinócitos/imunologia Masculino Camundongos Camundongos Endogâmicos BALB C Camundongos Endogâmicos C57BL Especificidade de Órgãos Fosforilação Fator de Transcrição STAT3/imunologia Transplante Homólogo [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (IDO1 protein, mouse); 0 (Immunologic Factors); 0 (Indoleamine-Pyrrole 2,3,-Dioxygenase); 0 (STAT3 Transcription Factor); 0 (Stat3 protein, mouse); 82115-62-6 (Interferon-gamma) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180213 [Lr] Data última revisão: 180213 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171231 [St] Status: MEDLINE

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[PMID]: 29201303 [Au] Autor: Rhee SM; Oh JH [Ad] Endereço: Department of Orthopedic Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea. [Ti] Título: Bridging Graft in Irreparable Massive Rotator Cuff Tears: Autogenic Biceps Graft versus Allogenic Dermal Patch Graft. [So] Source: Clin Orthop Surg;9(4):497-505, 2017 Dec. [Is] ISSN: 2005-4408 [Cp] País de publicação: Korea (South) [La] Idioma: eng [Ab] Resumo: Background: Few comparative studies have reported on the use of biologic grafts for irreparable massive rotator cuff tears. The purpose of this study was to assess the results of arthroscopic bridging graft in irreparable massive rotator cuff tears using an autogenic long head of biceps tendon (LHBT) or an allogenic dermal patch (ADP). Methods: We retrospectively reviewed 24 patients treated using the LHBT (group I) and eight patients with complete rupture of the LHBT treated using an ADP (group II) since 2011. Preoperative Goutallier's fatty degeneration, range of motion (ROM), visual analogue scale (VAS) for pain, American Shoulder and Elbow Surgeons (ASES) score, and Quick Disabilities of the Arm, Shoulder, and Hand (DASH) score were assessed and healing failure was evaluated at 1 year after surgery by ultrasonography or magnetic resonance imaging. Results: The mean fatty degeneration in groups I and II was 3.9 and 3.6 for the supraspinatus ( = 0.288), 2.7 and 2.9 for the infraspinatus ( = 0.685), 0.9 and 1.3 for the subscapularis ( = 0.314), and 1.3 and 3.0 for the teres minor ( = 0.005), respectively. Subscapularis tears were found in 8 patients (33.3%) in group I and in 7 patients (87.5%) in group II ( = 0.023). Mean ROMs and functional scores improved significantly in group I (forward flexion: 121.7° to 153.3°, = 0.010; external rotation: 32.7° to 52.7°, = 0.001; external rotation at 90°: 63.3° to 74.5°, = 0.031; internal rotation: T10.5 to T9.3, = 0.045; VAS: 7.0 to 1.1, p < 0.001; ASES score: 45.4 to 81.6, = 0.028; and Quick DASH score: 50.0 to 14.2, = 0.017), whereas only VAS showed significant improvement in group II (from 5.9 to 2.0, = 0.025) and ROMs and other functional scores increased without statistical significance in the group. Healing failure was found in 13 patients (54.2%) in group I and in 6 patients (75.0%) in group II ( = 0.404). Conclusions: The surgeon should prudently choose surgical options for irreparable massive rotator cuff tears, especially in patients with severe fatty degeneration in the teres minor or combined biceps and subscapularis tears. [Mh] Termos MeSH primário: Tecido Adiposo/patologia Lesões do Manguito Rotador/fisiopatologia Lesões do Manguito Rotador/cirurgia Articulação do Ombro/fisiopatologia Transplante de Pele Tendões/transplante [Mh] Termos MeSH secundário: Idoso Artroscopia Feminino Seres Humanos Imagem por Ressonância Magnética Masculino Meia-Idade Dor Musculoesquelética/etiologia Amplitude de Movimento Articular Estudos Retrospectivos Rotação Lesões do Manguito Rotador/complicações Lesões do Manguito Rotador/diagnóstico por imagem Articulação do Ombro/diagnóstico por imagem Transplante Autólogo Transplante Homólogo Ultrassonografia Cicatrização [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180207 [Lr] Data última revisão: 180207 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171205 [St] Status: MEDLINE [do] DOI: 10.4055/cios.2017.9.4.497

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[PMID]: 27779491 [Au] Autor: Sen H; Oruç M; Isik VM; Sadiç M; Sayar H; Çitil R; Korkmaz M; Koçer U [Ad] Endereço: From the *Adiyaman University Training and Research Hospital, Plastic, Reconstructive and Aesthetic Surgery Clinic, Adiyaman; †Ankara Training and Research Hospital Plastic, Reconstructive and Aesthetic Surgery Clinic, ‡Ankara Training and Research Hospital Nuclear Medicine Clinic, Ankara; §Faculty of Medicine, Pathology Department, Mersin University, Mersin; and ∥Kahramanmaras Necip Fazil City Hospital Pathology Clinic, Kahramanmaras, Turkey. [Ti] Título: The Effect of Omeprazole Usage on the Viability of Random Pattern Skin Flaps in Rats. [So] Source: Ann Plast Surg;78(6):e5-e9, 2017 Jun. [Is] ISSN: 1536-3708 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Necrosis of random pattern flaps caused by inadequate blood flow, especially in the distal part of the flap is one of the biggest challenges in reconstructive surgery. Various agents have been used to prevent flap ischemia. In this study, we used omeprazole, which is a potent inhibitor of gastric acidity to increase flap viability. METHODS: In this study, 35 Wistar-Albino type rats which were divided into 5 equal groups were used. Random-pattern dorsal skin flaps were raised in all groups at seventh day of the study. Group 1 was accepted as control group, and the rats in this group was only given distilled water intraperitoneally for 14 days. Group 2 and group 3 received 10 and 40 mg/kg omeprazole daily for 14 days, respectively. Group 4 and group 5 were given distilled water for the first 7 days and then after the operations they received 10 and 40 mg/kg omeprazole daily for 7 days, respectively. Survival rates of the flaps were examined seventh day after elevation of the flaps by digital imaging and scintigraphy. After assessment of the amount of necrosis, number of vascular structures were counted histopathologically. RESULTS: Percentage of flap necrosis was found to be less in all omeprazole received groups. On digital imaging, percentages of flap necrosis in the study groups were statistically significantly lower than that of the control group (P < 0.001), but there was no significant difference between the study groups (P > 0.05).In the histopathologic specimens, it was detected that the mean number of vessels in proximal (a) and distal (c) portions of the flap in the study groups showed a significant increase when compared with the control group (P < 0.01 for groups 2, 4 and 5, and P < 0.05 for group 3). CONCLUSIONS: In conclusion, possible clinical usage of medications increasing gastrin during flap surgeries can be thought as a positive contributor. In this sense, this study showed that parenteral administration of omeprazole in skin flap surgery increases flap viability possibly by increasing gastrin levels. [Mh] Termos MeSH primário: Sobrevivência de Enxerto/efeitos dos fármacos Omeprazol/farmacologia Retalhos Cirúrgicos/irrigação sanguínea [Mh] Termos MeSH secundário: Animais Feminino Interpretação de Imagem Assistida por Computador Necrose/diagnóstico por imagem Necrose/prevenção & controle Omeprazol/administração & dosagem Complicações Pós-Operatórias/diagnóstico por imagem Complicações Pós-Operatórias/prevenção & controle Ratos Ratos Wistar Transplante de Pele [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: KG60484QX9 (Omeprazole) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180129 [Lr] Data última revisão: 180129 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161026 [St] Status: MEDLINE [do] DOI: 10.1097/SAP.0000000000000922

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[PMID]: 29318258 [Au] Autor: Abbasi J [Ti] Título: Clinical Advances in Human Gene Therapies. [So] Source: JAMA;319(2):113, 2018 Jan 09. [Is] ISSN: 1538-3598 [Cp] País de publicação: United States [La] Idioma: eng [Mh] Termos MeSH primário: Epidermólise Bolhosa Juncional/terapia Edição de Genes Terapia Genética Mucopolissacaridose II/terapia Transplante de Pele [Mh] Termos MeSH secundário: Criança Vetores Genéticos Seres Humanos Masculino Mucopolissacaridose II/genética Transplante de Células-Tronco [Pt] Tipo de publicação: NEWS [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180123 [Lr] Data última revisão: 180123 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180111 [St] Status: MEDLINE [do] DOI: 10.1001/jama.2017.20692

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1			PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
2	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

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