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[PMID]:29054981
[Au] Autor:Dorval G; Lion M; Guérin S; Krid S; Galmiche-Rolland L; Salomon R; Boyer O
[Ad] Endereço:Department of Pediatric Nephrology, MARHEA - Necker Hospital - APHP, Imagine Institute, Paris Descartes University, Paris, France; and.
[Ti] Título:Immunoadsorption in Anti-GBM Glomerulonephritis: Case Report in a Child and Literature Review.
[So] Source:Pediatrics;140(5), 2017 Nov.
[Is] ISSN:1098-4275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Antiglomerular basement membrane glomerulonephritis (anti-GBM GN) is a rare autoimmune disease that is characterized by rapidly progressive glomerulonephritis that may be associated with pulmonary hemorrhage. Anti-GBM GN is caused by autoantibodies (classically type G immunoglobulin) directed against the α3 subunit of type IV collagen. Without any appropriate treatment, the disease is generally fulminant, and patient and kidney survival is poor. The current guidelines recommend the use of plasma exchanges and immunosuppressive drugs. Immunoadsorption (IA) can remove pathogenic IgGs from the circulation and do not require plasma infusions, contrary to plasma exchanges. IA has seldom been used in adult patients with good tolerance and efficiency. We report herein the first pediatric case successfully treated with IA combined with immunosuppressive drugs in a 7-year-old girl who presented acute kidney injury (estimated glomerular filtration rate 38 mL/minute/1.73 m ). A kidney biopsy revealed numerous >80% glomerular crescents and linear IgG deposits along the glomerular basement membrane. Ten IA sessions led to rapid and sustained clearance of autoantibodies and improvement of kidney function until 21 months after onset (glomerular filtration rate 87 mL/minute/1.73 m ). No adverse effect was noted. This report adds to the growing body of evidence suggesting IA as a therapeutic alternative to plasma exchanges in anti-GBM GN. The other 27 published pediatric cases of anti-GBM GN are reviewed.
[Mh] Termos MeSH primário: Autoanticorpos/sangue
Remoção de Componentes Sanguíneos/métodos
Glomerulonefrite/sangue
Glomerulonefrite/terapia
Imunossupressores/uso terapêutico
[Mh] Termos MeSH secundário: Adsorção
Criança
Feminino
Glomerulonefrite/diagnóstico
Seres Humanos
Tolerância Imunológica/efeitos dos fármacos
Tolerância Imunológica/fisiologia
Técnicas de Imunoadsorção
Imunossupressores/farmacologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Autoantibodies); 0 (Immunosuppressive Agents); 0 (antiglomerular basement membrane antibody)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171022
[St] Status:MEDLINE


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[PMID]:28912035
[Au] Autor:Lazaridis K; Dalianoudis I; Baltatzidi V; Tzartos SJ
[Ad] Endereço:Hellenic Pasteur Institute, Athens, Greece. Electronic address: klazaridis@pasteur.gr.
[Ti] Título:Specific removal of autoantibodies by extracorporeal immunoadsorption ameliorates experimental autoimmune myasthenia gravis.
[So] Source:J Neuroimmunol;312:24-30, 2017 Nov 15.
[Is] ISSN:1872-8421
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Myasthenia gravis (MG) is caused by autoantibodies, the majority of which target the muscle acetylcholine receptor (AChR). Plasmapheresis and IgG-immunoadsorption are useful therapy options, but are highly non-specific. Antigen-specific immunoadsorption would remove only the pathogenic autoantibodies, reducing the possibility of side effects while maximizing the benefit. We have extensively characterized such adsorbents, but in vivo studies are missing. We used rats with experimental autoimmune MG to perform antigen-specific immunoadsorptions over three weeks, regularly monitoring symptoms and autoantibody titers. Immunoadsorption was effective, resulting in a marked autoantibody titer decrease while the immunoadsorbed, but not the mock-treated, animals showed a dramatic symptom improvement. Overall, the procedure was found to be efficient, suggesting the subsequent initiation of clinical trials.
[Mh] Termos MeSH primário: Autoanticorpos/sangue
Remoção de Componentes Sanguíneos/métodos
Imunoadsorventes/uso terapêutico
Miastenia Gravis Autoimune Experimental/imunologia
Miastenia Gravis Autoimune Experimental/terapia
[Mh] Termos MeSH secundário: Animais
Peso Corporal
Modelos Animais de Doenças
Eletromiografia
Feminino
Miastenia Gravis Autoimune Experimental/metabolismo
Miastenia Gravis Autoimune Experimental/fisiopatologia
Ratos
Ratos Endogâmicos Lew
Receptores Colinérgicos/imunologia
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Autoantibodies); 0 (Immunosorbents); 0 (Receptors, Cholinergic)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170916
[St] Status:MEDLINE


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[PMID]:28815621
[Au] Autor:Lodermeier MA; Byrne KM; Flegel WA
[Ad] Endereço:Department of Transfusion Medicine, National Institutes of Health Clinical Center, National Institutes of Health, Bethesda, Maryland.
[Ti] Título:Red blood cell sedimentation of Apheresis Granulocytes.
[So] Source:Transfusion;57(10):2551-2552, 2017 Oct.
[Is] ISSN:1537-2995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sedimentation of Apheresis Granulocyte components removes red blood cells. It is used to increase the blood donor pool when blood group-compatible donors cannot be recruited for a patient because of a major ABO incompatibility or incompatible red blood cell antibodies in the recipient. Because granulocytes have little ABO and few other red blood cell antigens on their membrane, such incompatibility lies mostly with the contaminating red blood cells. Video Clip S1 shows the process of red blood cell sedimentation of an Apheresis Granulocyte component. This video was filmed with a single smart phone attached to a commercial tripod and was edited on a tablet computer with free software by an amateur videographer without prior video experience.
[Mh] Termos MeSH primário: Sedimentação Sanguínea
Granulócitos/citologia
Gravação em Vídeo/instrumentação
[Mh] Termos MeSH secundário: Remoção de Componentes Sanguíneos
Doadores de Sangue/provisão & distribuição
Incompatibilidade de Grupos Sanguíneos
Seres Humanos
Smartphone
Software
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.1111/trf.14251


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[PMID]:28681364
[Au] Autor:Ichikawa H; Imai J; Mizukami H; Shirai T; Watanabe N
[Ad] Endereço:Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University Hachioji Hospital, 1838 Ishikawa-machi Hachioji, Tokyo 192-0032, Japan. ih0319@tokai.ac.jp.
[Ti] Título:Treatment of a Case of Ulcerative Colitis with Sacroiliitis Using Granulocyte and Monocyte Adsorption Apheresis.
[So] Source:Tokai J Exp Clin Med;42(2):64-66, 2017 Jul 20.
[Is] ISSN:2185-2243
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:In Japan, sacroiliitis is a very rare extraintestinal manifestation in patients with ulcerative colitis (UC), and it typically presents with intestinal symptoms. Radiography is used for diagnosis, and reveals erosions, sclerosis, and ankylosis, but magnetic resonance imaging is more useful for early detection. The treatment of spondyloarthropathy such as sacroiliitis and spondylitis includes physiotherapy, nonsteroidal anti-inflammatory drugs, sulfasalazine, and immunomodulators. In patients intolerant or cases refractory to these treatments, anti-tumor necrosis factor agents are recommended. Granulocyte and monocyte adsorption (GMA) apheresis was developed in Japan in the 1980s, and is currently used widely in clinical practice for UC patients. Unlike conventional medication, GMA apheresis has no serious adverse effects. We present the first report of a UC patient with sacroiliitis, who responded well to GMA therapy. GMA apheresis may be considered a new treatment option for UC-associated spondyloarthropathy that is refractory or tolerant to conventional treatment.
[Mh] Termos MeSH primário: Remoção de Componentes Sanguíneos/métodos
Colite Ulcerativa/complicações
Colite Ulcerativa/terapia
Granulócitos
Monócitos
Sacroileíte/etiologia
Sacroileíte/terapia
[Mh] Termos MeSH secundário: Adulto
Colite Ulcerativa/diagnóstico por imagem
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Sacroileíte/diagnóstico por imagem
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE


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[PMID]:28653370
[Au] Autor:Grommé M; Russcher H; Braakman E; Klinkspoor JH; Dobber JA; de Greef I; de Wit NCJ
[Ad] Endereço:Department of Internal Medicine, Division of Haematology, Erasmus Medical Centre, Rotterdam, the Netherlands.
[Ti] Título:Multicenter study to evaluate a new enumeration method for hematopoietic stem cell collection management.
[So] Source:Transfusion;57(8):1949-1955, 2017 Aug.
[Is] ISSN:1537-2995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: CD34 flow cytometry is the gold standard for stem cell enumeration in peripheral blood at the mobilization stage and in the final apheresis product. The new stem cell mode of the Sysmex XN Series analyzer enumerates an immature cell population in the white progenitor and pathological cell (WPC) channel, based on the cell size, internal cellular complexity, and fluorescence intensity. STUDY DESIGN AND METHODS: In this multicenter study we analyzed 147 peripheral blood samples, 22 samples during collection of stem cells, and 45 samples from the apheresis product of 18 healthy allogeneic donors and 84 autologous patients. RESULTS: In this multicenter study we demonstrate that the XN stem cell enumeration method correlates well with viable CD34+ cells determined by flow cytometry during the stem cell mobilization phase to determine apheresis start time, during apheresis for real-time monitoring and adjustment, and for quality control of the final stem cell harvest. CONCLUSION: Our data show that there is an improvement in the correlation of XN stem cells and CD34+ cells in the peripheral blood during stem cell mobilization as well as in stem cell harvests compared to SE or XE Series analyzers. The XN stem cell enumeration method has a number of advantages compared to CD34 flow cytometry: it is fast, simple, reproducible, and less expensive. CE marking for the European market has been obtained, making the stem cell count on the XN analyzer a reportable clinical variable.
[Mh] Termos MeSH primário: Contagem de Células Sanguíneas/instrumentação
Células-Tronco Hematopoéticas/citologia
[Mh] Termos MeSH secundário: Antígenos CD34/sangue
Contagem de Células Sanguíneas/economia
Contagem de Células Sanguíneas/métodos
Contagem de Células Sanguíneas/normas
Remoção de Componentes Sanguíneos/normas
Custos e Análise de Custo
Mobilização de Células-Tronco Hematopoéticas/normas
Seres Humanos
Reprodutibilidade dos Testes
Fatores de Tempo
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Antigens, CD34)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE
[do] DOI:10.1111/trf.14183


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[PMID]:28592046
[Au] Autor:Liu ZF; Zheng HH; Jiang XL
[Ti] Título:[The application of selectie granulocyte and monocyte apheresis in the treatment of ulcerative colitis].
[So] Source:Zhonghua Nei Ke Za Zhi;56(6):444-446, 2017 Jun 01.
[Is] ISSN:0578-1426
[Cp] País de publicação:China
[La] Idioma:chi
[Mh] Termos MeSH primário: Colite Ulcerativa/terapia
Granulócitos
Leucaférese/métodos
Monócitos
[Mh] Termos MeSH secundário: Adulto
Remoção de Componentes Sanguíneos
Feminino
Seres Humanos
Masculino
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170609
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0578-1426.2017.06.012


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[PMID]:28516871
[Au] Autor:Conti F; Priori R; Alessandri C; Misasi R; Capozzi A; Pendolino M; Truglia S; Frisenda S; Sorice M; Valesini G
[Ad] Endereço:Reumatologia, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Italy.
[Ti] Título:Diagnosis of catastrophic anti-phospholipid syndrome in a patient tested negative for conventional tests.
[So] Source:Clin Exp Rheumatol;35(4):678-680, 2017 Jul-Aug.
[Is] ISSN:0392-856X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Catastrophic antiphospholipid syndrome (CAPS) is a severe variant of APS, characterised by clinical evidence of multiple organ involvement developing over a very short period of time, histopathological evidence of multiple small vessel occlusions and laboratory confirmation of the presence of aPL (lupus anticoagulant and/or anticardiolipin antibodies and/or anti-Beta2-glcyoprotein I antibodies). Here we report a case of a 39-year-old woman patient who developed a CAPS which was negative to the conventional aPL but positive for aPL in thin layer chromatography immunostaining and vimentin/cardiolipin antibodies by ELISA test. The patient was treated with high doses of glucocorticoids, intravenous immunoglobulins plasma exchange and immunoadsorbent apheresis with a significant improvement of the ischaemic lesions of the hands even though the necrosis of the feet progressively worsened. As a result, the patient underwent partial surgical amputation of the feet. To our knowledge, this is the first ever reported case of CAPS diagnosed by means of thin layer chromatography immunostaining and vimentin/cardiolipin antibody ELISA test.
[Mh] Termos MeSH primário: Anticorpos Anticardiolipina/imunologia
Síndrome Antifosfolipídica/imunologia
Arteriopatias Oclusivas/imunologia
Vimentina/imunologia
[Mh] Termos MeSH secundário: Adulto
Amputação
Anticorpos Antifosfolipídeos/imunologia
Síndrome Antifosfolipídica/complicações
Síndrome Antifosfolipídica/diagnóstico
Síndrome Antifosfolipídica/terapia
Arteriopatias Oclusivas/diagnóstico por imagem
Arteriopatias Oclusivas/etiologia
Remoção de Componentes Sanguíneos
Cromatografia em Camada Delgada
Angiografia por Tomografia Computadorizada
Ensaio de Imunoadsorção Enzimática
Feminino
Glucocorticoides/uso terapêutico
Seres Humanos
Imunoglobulinas Intravenosas/uso terapêutico
Fatores Imunológicos/uso terapêutico
Artéria Poplítea/diagnóstico por imagem
Artérias da Tíbia/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Anticardiolipin); 0 (Antibodies, Antiphospholipid); 0 (Glucocorticoids); 0 (Immunoglobulins, Intravenous); 0 (Immunologic Factors); 0 (Vimentin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170519
[St] Status:MEDLINE


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[PMID]:28514773
[Au] Autor:Ruiz-Argüelles GJ; León-Peña AA; León-González M; Nuñez-Cortes AK; Olivares-Gazca JC; Murrieta-Alvarez I; Vargas-Espinosa J; Medina-Ceballos E; Cantero-Fortiz Y; Ruiz-Argüelles A; Ruiz-Delgado MA; Ruiz-Delgado RJ; Ruiz-Reyes G; Priesca-Marín M; Torres-Priego MS; Blumenkron-Marroquin D; Ruiz-Delgado GJ
[Ad] Endereço:Centro de Hematología y Medicina Interna de Puebla, Puebla, Mexico.
[Ti] Título:A Feasibility Study of the Full Outpatient Conduction of Hematopoietic Transplants in Persons with Multiple Sclerosis Employing Autologous Non-Cryopreserved Peripheral Blood Stem Cells.
[So] Source:Acta Haematol;137(4):214-219, 2017.
[Is] ISSN:1421-9662
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: With the goal of achieving immune system reset, autologous hematopoietic stem cell transplantations have been performed in patients with multiple sclerosis (MS). MATERIAL AND METHODS: Two hundred and eighty-six consecutive patients with MS were autografted in a single center using non-frozen peripheral blood stem cells (PBSCs), on an outpatient basis and conditioning with cyclophosphamide and rituximab. The protocol was registered in ClinicalTrials.gov identifier NCT02674217. RESULTS: One hundred and ninety-four females and 92 males were included; the median age was 47. All procedures were started on an outpatient basis and only 8 persons needed to be admitted to the hospital during the procedure. In order to obtain at least 1 × 106/kg viable CD34 cells, 1-4 aphereses were performed (median 1). The total number of viable CD34+ cells infused ranged between 1 and 19.2 × 106/kg (median 4.6). Patients recovered above 0.5 × 109/L absolute granulocytes on median day 8 (range 0-12). Two individuals needed red blood cells but none needed platelet transfusions. There were no transplant-related deaths and the 128-month overall survival of the patients is 100%. In 82 persons followed up for 3 or more months, the Expanded Disability Status Scale diminished from a mean of 5.2-4.9, the best results being obtained in relapsing-remitting and primary progressive MS. CONCLUSIONS: It is possible to conduct autotransplants for patients with MS employing non-frozen PBSCs and outpatient conduction. Additional information is needed to assess the efficacy of these procedures in the treatment of patients with MS.
[Mh] Termos MeSH primário: Esclerose Múltipla/terapia
Transplante de Células-Tronco de Sangue Periférico/métodos
[Mh] Termos MeSH secundário: Adulto
Assistência Ambulatorial
Remoção de Componentes Sanguíneos
Criopreservação
Estudos de Viabilidade
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Condicionamento Pré-Transplante
Transplante Autólogo
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170518
[St] Status:MEDLINE
[do] DOI:10.1159/000469655


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[PMID]:28439898
[Au] Autor:Even-Or E; Di Mola M; Ali M; Courtney S; McDougall E; Alexander S; Schechter T; Whitlock JA; Licht C; Krueger J
[Ad] Endereço:Division of Haematology/Oncology/Bone Marrow Transplantation, The Hospital for Sick Children, Toronto, Ontario, Canada.
[Ti] Título:Optimizing autologous nonmobilized mononuclear cell collections for cellular therapy in pediatric patients with high-risk leukemia.
[So] Source:Transfusion;57(6):1536-1542, 2017 Jun.
[Is] ISSN:1537-2995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The manufacturing of cellular products for immunotherapy, such as chimeric antigen receptor T cells, requires successful collection of mononuclear cells. Collections from children with high-risk leukemia present a challenge, especially because the established COBE Spectra apheresis device is being replaced by the novel Spectra Optia device (Optia) in many institutions. Published experience for mononuclear cell collections in children with Optia is lacking. Our aim was to compare the two collection devices and describe modified settings on the Optia to optimize mononuclear cell collections. STUDY DESIGN AND METHODS: As a quality initiative, we retrospectively collected and compared data from mononuclear cell collections on both devices. Collected data included patient's clinical characteristics; collection parameters, including precollection lymphocyte/CD3 counts, total blood volumes processed, runtimes, and side effects (including complete blood count and electrolyte changes); and product characteristics, including volumes and cell counts. Collection efficiencies and collection ratios were calculated. RESULTS: Twenty-six mononuclear cell collections were performed on 20 pediatric patients: 11 with COBE and 15 with Optia. Adequate mononuclear cell products were successfully collected with a single procedure from all patients except one, with mean calculated mononuclear cell collection efficiency that was significantly higher from Optia collections compared with COBE collections (57.9 ± 4.6% vs 40.3 ± 6.2%, respectively; p = 0.04). CD3-positive yields were comparable on both machines (p = 0.34) with significantly smaller blood volumes processed on Optia. Collected products had larger volumes on Optia. No significant side effects attributed to the procedure were noted. CONCLUSION: Mononuclear cell apheresis using the Optia device in children is more efficient and is as safe as that with the COBE device.
[Mh] Termos MeSH primário: Remoção de Componentes Sanguíneos/métodos
Imunoterapia/métodos
Leucemia/terapia
Leucócitos Mononucleares/citologia
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Leucócitos Mononucleares/transplante
Masculino
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170426
[St] Status:MEDLINE
[do] DOI:10.1111/trf.14094


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[PMID]:28379034
[Au] Autor:Bláha V; Bláha M; Lánská M; Solichová D; Kujovská Krcmová L; Havel E; Vyroubal P; Zadák Z; Zák P; Sobotka L
[Ad] Endereço:Third Department of Internal Medicine, Metabolism and Gerontology, University Hospital Hradec Králové and Charles University Faculty of Medicine in Hradec Králové, Hradec Králové, Czech Republic. blaha@lfhk.cuni.cz.
[Ti] Título:Lipoprotein apheresis in the treatment of dyslipidaemia - the Czech Republic experience.
[So] Source:Physiol Res;66(Supplementum 1):S91-S100, 2017 Apr 05.
[Is] ISSN:1802-9973
[Cp] País de publicação:Czech Republic
[La] Idioma:eng
[Ab] Resumo:In 1984, we started using therapeutic plasmapheresis (plasma exchange) as a method of extracorporeal lipoprotein elimination for the treatment of hypercholesterolemic patients. We evaluated the results of long-term therapy in 14 patients, 8 men and 6 women. The average age was 55.6+/-13.2 (range 28-70), median 59.5 years. 14 patients were diagnosed with familial hypercholesterolemia (FH): 5 homozygous, 9 heterozygous. Ten patients in the group were treated using immunoadsorption lipoprotein apheresis and 4 using hemorheopheresis. Immunoapheretic interventions decreased LDL-cholesterol (82+/-1 %), ApoB (73+/-13 %) and even Lp(a) by 82+/-19 %, respectively. Selected non-invasive methods are important for long-term and repeated follow-up. Carotid intima-media thickness showed improvement or stagnation in 75 % of the patients. Biomarkers of endothelial dysfunction such as endoglin (in the control group: 3.85+/-1.25 microg/l, in lipoprotein apheresis-treated hypercholesterolemic individuals 5.74+/-1.47 microg/l), CD40 ligand (before lipoprotein apheresis: 6498+/-2529 ng/l, after lipoprotein apheresis: 4057+/-2560 ng/l) and neopterin (before lipoprotein apheresis: 5.7+/-1.1 nmol/l, after lipoprotein apheresis: 5.5+/-1.3 nmol/l) related to the course of atherosclerosis, but did not reflect the actual activity of the disease nor facilitate the prediction or planning of therapy. Hemorheopheresis may improve blood flow in microcirculation in familial hypercholesterolemia and also in some other microcirculation disorders via significantly decreased activity of thrombomodulin (p<0.0001), tissue factor (p<0.0001), aggregation of thrombocytes (p<0.0001) and plasma and whole blood viscosity (p<0.0001). In conclusion, lipoprotein apheresis and hemorheopheresis substantially lowered LDL-cholesterol in severe hypercholesterolemia. Our experience with long-term therapy also shows good tolerance and a small number of complications (6.26 % non-serious clinical complications).
[Mh] Termos MeSH primário: Remoção de Componentes Sanguíneos/métodos
LDL-Colesterol/sangue
Dislipidemias/sangue
Dislipidemias/terapia
Lipoproteínas/sangue
[Mh] Termos MeSH secundário: Adulto
Idoso
Espessura Intima-Media Carotídea
República Tcheca/epidemiologia
Dislipidemias/epidemiologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cholesterol, LDL); 0 (Lipoproteins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE



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