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  1 / 2091 MEDLINE  
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[PMID]:29384305
[Au] Autor:Aké-Tano SOP; Kpebo DO; Konan YE; Tetchi EO; Sable SP; Ekou FK; Attoh TH; Aka LN; Diarassouba B; Dagnan NCS
[Ti] Título:[Abortion practices in high school students in Yamoussoukro, Côte d'Ivoire].
[Ti] Título:Pratiques d?avortement chez des lycéennes à Yamoussoukro, Côte d?Ivoire..
[So] Source:Sante Publique;29(5):711-717, 2017 Dec 05.
[Is] ISSN:0995-3914
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:INTRODUCTION: Induced abortion is illegal in Cote d'Ivoire, except when the mother's life is in danger. The primary objective of this study was to describe abortion practices among Yamoussoukro high school students. More specifically, this study estimated the prevalence of induced abortion, described the pathway and the methods used for abortion and determined any abortion-related complications. MATERIAL AND METHODS: This cross-sectional study was conducted in July 2011 on 312 randomly selected girls attending the Lycée Jeunes Filles in Yamoussoukro. RESULTS: These girls had a mean age (SD) of 16.1 (4.7) years; 258 (82.7%) of them had already had sexual intercourse and 81 (31.4%) had already been pregnant. Fifty (61.7% [56.3-67.1%]) of these 81 girls had already had an abortion. The abortion pathway was as follows: the main method was self-prescribed medication (70%) as first attempt, followed, in case of failure, by traditional healers (56.4%). Healthcare practitioners were usually consulted at the third attempt (85.7%). The most commonly used methods of abortion were drugs (91.9%), ingestion of plants/beverages (68.5%) and introduction of devices into the uterine cavity (62.3%). Twenty-two (44%) out of 50 induced abortions resulted in complications, mostly infectious complications (81.8%), and bleeding (68.2%). Complications were significantly associated with self-induced abortions or abortions performed by traditional healers (p < 0.001). CONCLUSION: More intensive sexual education, access to modern methods of contraception, awareness campaigns concerning the risks related to unwanted pregnancies and abortions performed by non-medical personnel need to be implemented to prevent school abortions. The quality and accessibility of post-abortion services also need to be reinforced.
[Mh] Termos MeSH primário: Aborto Induzido/métodos
Aborto Induzido/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adolescente
Costa do Marfim
Estudos Transversais
Feminino
Seres Humanos
Medicina Tradicional Africana
Gravidez
Gravidez não Desejada
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.3917/spub.175.0711


  2 / 2091 MEDLINE  
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[PMID]:29268027
[Au] Autor:Gouws C; Hamman JH
[Ad] Endereço:a Pharmacen™, Centre of Excellence for Pharmaceutical Sciences , North-West University , Potchefstroom , South Africa.
[Ti] Título:Recent developments in our understanding of the implications of traditional African medicine on drug metabolism.
[So] Source:Expert Opin Drug Metab Toxicol;14(2):161-168, 2018 Feb.
[Is] ISSN:1744-7607
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The use of traditional herbal medicines has become increasingly popular globally, but in some countries, it is the main or sometimes even the only healthcare service available in the most rural areas. This is especially true for Africa where herbal medicines form a key component of traditional medicinal practices and there is access to a diversity of medicinal plants. Although many benefits have been derived from the use of traditional herbal medicines, many concerns are associated with their use of which herb-drug interactions have been identified to have a rising impact on patient treatment outcome. One type of pharmacokinetic interaction involves the modulation of drug metabolizing enzymes, which may result in enhanced or reduced bioavailability of co-administered drugs. Areas covered: This review highlights the current information available on drug metabolism-associated information with regards to traditional African medicines related to some of the most prevalent diseases burdening the African continent. Expert opinion: It is clear from previous studies that enzyme modulation by traditional African medicines plays a significant role in the pharmacokinetics of some co-administered drugs, but more research is needed to provide detailed information on these interactions, specifically for treatment of prevalent diseases such as tuberculosis and hypertension.
[Mh] Termos MeSH primário: Interações Ervas-Drogas
Preparações de Plantas/administração & dosagem
Plantas Medicinais/química
[Mh] Termos MeSH secundário: Animais
Disponibilidade Biológica
Seres Humanos
Medicina Tradicional Africana/métodos
Preparações Farmacêuticas/metabolismo
Preparações de Plantas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Pharmaceutical Preparations); 0 (Plant Preparations)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.1080/17425255.2018.1421171


  3 / 2091 MEDLINE  
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[PMID]:29261705
[Au] Autor:Audet CM; Ngobeni S; Graves E; Wagner RG
[Ad] Endereço:Vanderbilt Institute for Global Health, Vanderbilt University, Nashville, United States of America.
[Ti] Título:Mixed methods inquiry into traditional healers' treatment of mental, neurological and substance abuse disorders in rural South Africa.
[So] Source:PLoS One;12(12):e0188433, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Traditional healers are acceptable and highly accessible health practitioners throughout sub-Saharan Africa. Patients in South Africa often seek concurrent traditional and allopathic treatment leading to medical pluralism. METHODS & FINDINGS: We studied the cause of five traditional illnesses known locally as "Mavabyi ya nhloko" (sickness of the head), by conducting 27 in-depth interviews and 133 surveys with a randomly selected sample of traditional healers living and working in rural, northeastern South Africa. These interviews were carried out to identify treatment practices of mental, neurological, and substance abuse (MNS) disorders. Participating healers were primarily female (77%), older in age (median: 58.0 years; interquartile range [IQR]: 50-67), had very little formal education (median: 3.7 years; IQR: 3.2-4.2), and had practiced traditional medicine for many years (median: 17 years; IQR: 9.5-30). Healers reported having the ability to successfully treat: seizure disorders (47%), patients who have lost touch with reality (47%), paralysis on one side of the body (59%), and substance abuse (21%). Female healers reported a lower odds of treating seizure disorders (Odds Ratio (OR):0.47), patients who had lost touch with reality (OR:0.26; p-value<0.05), paralysis of one side of the body (OR:0.36), and substance abuse (OR:0.36) versus males. Each additional year of education received was found to be associated with lower odds, ranging from 0.13-0.27, of treating these symptoms. Each additional patient seen by healers in the past week was associated with roughly 1.10 higher odds of treating seizure disorders, patients who have lost touch with reality, paralysis of one side of the body, and substance abuse. Healers charged a median of 500 South African Rand (~US$35) to treat substance abuse, 1000 Rand (~US$70) for seizure disorders or paralysis of one side of the body, and 1500 Rand (~US$105) for patients who have lost touch with reality. CONCLUSIONS: While not all healers elect to treat MNS disorders, many continue to do so, delaying allopathic health services to acutely ill patients.
[Mh] Termos MeSH primário: Medicina Tradicional Africana
Transtornos Mentais/terapia
Doenças do Sistema Nervoso/terapia
Transtornos Relacionados ao Uso de Substâncias/terapia
[Mh] Termos MeSH secundário: Idoso
Custos e Análise de Custo
Demografia
Feminino
Seres Humanos
Masculino
Medicina Tradicional Africana/economia
Transtornos Mentais/diagnóstico
Transtornos Mentais/economia
Meia-Idade
Doenças do Sistema Nervoso/diagnóstico
Doenças do Sistema Nervoso/economia
Encaminhamento e Consulta
África do Sul
Transtornos Relacionados ao Uso de Substâncias/diagnóstico
Transtornos Relacionados ao Uso de Substâncias/economia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188433


  4 / 2091 MEDLINE  
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[PMID]:28983391
[Au] Autor:Tegegne AA; Mersha AM
[Ad] Endereço:World Health Organization Country Office, Addis Ababa, Ethiopia.
[Ti] Título:Health care seeking behavior of parents with acute flaccid paralysis child.
[So] Source:Pan Afr Med J;27(Suppl 2):3, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Despite the tremendous increase in the number of modern health institutions, traditional medical practices still remain alternative places of health care service delivery and important sites for disease notification in the disease surveillance system. The objectives of this study are to describe the patterns and factors associated with health care seeking behavior of parents and care takers with acute flaccid paralysis child and see how the traditional practice affect the surveillance system. METHODS: A cross-sectional descriptive study was conducted to assess the health seeking behavior of parents with an acute flaccid paralysis child. Data were collected throughout the country as a routine surveillance program. RESULTS: Of 1299 families analyzed, 907(69.3%) of families with AFP child first went to health institutions to seek medical care, while. 398 (30.7%) of parents took their child first to other traditional sites, including holy water sites (11.8%), traditional healers (9.1%) and prayer places (5.4%). Over half of the parents with AFP child reported practicing home measures before first seeking health service from modern health institutions. Home measures (OR, 0.1202, 95% CI 0.0804-0.1797), decision by relatives (OR, 0.5595, 95% CI 0.3665-0.8540) and More than 10km distance from health facility (OR, 0.5962, 95% CI, 0.4117-0.8634) were significantly associated to first seeking health service from health institutions (p<0.05). CONCLUSION: Program strategies must certainly be developed to expand and capture all traditional sites in the surveillance network, and intensify sensitization and active surveillance visit in these areas.
[Mh] Termos MeSH primário: Assistência à Saúde/métodos
Paralisia/terapia
Aceitação pelo Paciente de Cuidados de Saúde/estatística & dados numéricos
Poliomielite/terapia
[Mh] Termos MeSH secundário: Doença Aguda
Adolescente
Criança
Pré-Escolar
Estudos Transversais
Assistência à Saúde/estatística & dados numéricos
Etiópia
Seres Humanos
Masculino
Medicina Tradicional Africana/utilização
Paralisia/etiologia
Pais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.supp.2017.27.2.11023


  5 / 2091 MEDLINE  
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[PMID]:28910132
[Au] Autor:Vinesett AL; Whaley RR; Woods-Giscombe C; Dennis P; Johnson M; Li Y; Mounzeo P; Baegne M; Wilson KH
[Ad] Endereço:1 Duke Dance Program, Duke University , Durham, NC.
[Ti] Título:Modified African Ngoma Healing Ceremony for Stress Reduction: A Pilot Study.
[So] Source:J Altern Complement Med;23(10):800-804, 2017 Oct.
[Is] ISSN:1557-7708
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Indigenous people's ceremonies using rhythm and dance have been used for countless generations throughout the world for healing, conflict resolution, social bonding, and spiritual experience. A previous study reported that a ceremony based on the Central African ngoma tradition was favorably received by a group of Americans. The present trial compared the effects of the modified ngoma ceremony (Ngoma) with those of mindfulness-based stress reduction (MBSR) in a randomized pilot study. METHODS: Twenty-one women were randomized to either Ngoma or MBSR. Both groups had sessions on a weekly basis for 8 weeks and completed questionnaires at baseline, week 8, and 1 month after the intervention. Participants completed questionnaires, which included self-report of depressive and anxiety symptoms, health status (e.g., quality of life and functioning), social bonding, and perception of the credibility of the two interventions. RESULTS: Both groups showed improvements in depression, anxiety, emotional well being, and social functioning as measured by respective scales. Social bonding also increased in both groups during the study and may be a mechanism for both interventions. Participants found both interventions credible. CONCLUSIONS: In this pilot study, Ngoma showed significant and durable beneficial effects comparable to MBSR. The effects of Ngoma and other indigenous rhythm-dance ceremonies on distress and health status in western culture should be investigated in larger clinical studies.
[Mh] Termos MeSH primário: Terapia através da Dança
Medicina Tradicional Africana
Atenção Plena
Estresse Psicológico/terapia
[Mh] Termos MeSH secundário: Adulto
Ansiedade/terapia
Comportamento Ritualístico
Depressão
Feminino
Seres Humanos
Masculino
Meia-Idade
Projetos Piloto
Distribuição Aleatória
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE
[do] DOI:10.1089/acm.2016.0410


  6 / 2091 MEDLINE  
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[PMID]:28854905
[Au] Autor:Audet CM; Ngobeni S; Wagner RG
[Ad] Endereço:Vanderbilt Institute for Global Health, Vanderbilt University, 2525 West End Avenue, Suite 750, Nashville, TN, 37203-1738, USA. carolyn.m.audet@vanderbilt.edu.
[Ti] Título:Traditional healer treatment of HIV persists in the era of ART: a mixed methods study from rural South Africa.
[So] Source:BMC Complement Altern Med;17(1):434, 2017 Aug 30.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Human immunodeficiency virus (HIV) substantially contributes to the burden of disease and health care provision in sub-Saharan Africa, where traditional healers play a major role in care, due to both their accessibility and acceptability. In rural, northeastern South Africa, people living with HIV often ping-pong between traditional healers and allopathic providers. METHODS: We conducted 27 in-depth interviews and 133 surveys with a random sample of traditional healers living in Bushbuckridge, South Africa, where anti-retroviral therapy (ART) is publicly available, to learn: (1) healer perspectives about which HIV patients they choose to treat; (2) the type of treatment offered; (3) outcomes expected, and; (4) the cost of delivering treatment. RESULTS: Healers were mostly female (77%), older (median: 58.0 years; interquartile range [IQR]: 50-67), with low levels of formal education (median: 3.7 years; IQR: 3.2-4.2). Thirty-nine healers (30%) reported being able to cure HIV in an adult patients whose (CD4) count was >350cells/mm . If an HIV-infected patient preferred traditional treatment, healers differentiated two categories of known HIV-infected patients, CD4+ cell counts <350 or ≥350 cells/mm . Patients with low CD4 counts were routinely referred back to the health facility. Healers who reported offering/performing a traditional cure for HIV had practiced for less time (mean = 16.9 vs. 22.8 years; p = 0.03), treated more patients (mean 8.7 vs. 4.8 per month; p = 0.03), and had lower levels of education (mean = 2.8 vs. 4.1 years; p = 0.017) when compared to healers who reported not treating HIV-infected patients. Healers charged a median of 92 USD to treat patients with HIV. CONCLUSION: Traditional healers referred suspected HIV-infected patients to standard allopathic care, yet continued to treat HIV-infected patients with higher CD4 counts. A greater emphasis on patient education and healer engagement is warranted.
[Mh] Termos MeSH primário: Infecções por HIV/terapia
Medicina Tradicional Africana
Terapias Espirituais
[Mh] Termos MeSH secundário: Idoso
Fármacos Anti-HIV/administração & dosagem
Contagem de Linfócito CD4
Feminino
Infecções por HIV/tratamento farmacológico
Infecções por HIV/imunologia
Infecções por HIV/psicologia
Seres Humanos
Masculino
Medicina Tradicional Africana/psicologia
Meia-Idade
África do Sul
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-HIV Agents)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1934-6


  7 / 2091 MEDLINE  
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[PMID]:28800757
[Au] Autor:Ngouateu Teufack SE; NMbogning Tayo G; Ngangout Alidou M; Yondo J; Djiomene AF; Wabo Poné J; Mbida FM
[Ad] Endereço:Research Unit of Biology and Applied Ecology, Department of Animal Biology, Faculty of Science, University of Dschang, P.O. Box 067, Dschang, Cameroon.
[Ti] Título:Anthelminthic properties of Methylene chloride-methanol (1:1) extracts of two Cameroonians medicinal plants on Heligmosomoides bakeri (Nematoda: Heligmosomatidea).
[So] Source:BMC Complement Altern Med;17(1):400, 2017 Aug 11.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The resistance of some medico-veterinary parasite strains as well as the unavailability and toxicity of synthetic anthelminthics on humans, animals and the impacts of their residues in the environment have pushed scientists to turn to plants with anthelminthic properties. Hence, the aim of this work was to contribute to the fight against helminths of medical and veterinary importance in general, and also to clear the environment of their free living stages. METHODS: Fresh eggs of Heligmosomoides bakeri were obtained from the faeces of experimentally infected mice. L and L larval stages were obtained after 48 and 72 h of coproculture respectively. Methylene Chloride-Methanol (1:1) extracts of Annona senegalensis and Nauclea latifolia were diluted in DMSO or Tween 80 to prepare the following concentrations: 625, 1250, 2500, 3750 and 5000 µg/ml. The effects of extract solutions were evaluated on the embryonation of eggs, egg hatching and on L and L survival after 48, 10 and 24 h of incubation. Negative controls were 1.5% DMSO, 4% Tween 80 and a mixture of these solvents. The TLC was carried out and the profiles of secondary metabolites were made. RESULTS: Negative controls had no effect on the embryonation, eggs hatching and on larval mortality. However, it was found that, the extracts affected the free living stages of H. bakeri in a concentration-dependant manner. At the highest concentration (5000 µg/ml), the rate of inhibition of embryonation obtained were 20.80%, 38.15% and 84.83% for Methylene Chloride-Methanol of Annona senegalensis (MCM As), Nauclea latifolia (MCM Nl) extracts and mixture of Annona senegalensis and Nauclea latifolia (MCM As-Nl) extract respectively. For egg hatch, the inhibition rate was 16.10%, 46.24% and 87.07% for the above three extracts respectively at the same concentration of 5000 µg/ml. On L and L larval stages after 24 h of exposure to extracts, the mortality rates of 100%, 54.76% and 96.77% against 98%, 51.44% and 100% were obtained for MCM As, MCM Nl and MCM As-Nl respectively at the highest concentration. The Methylene Chloride-Methanol of A.senegalensis, N. latifolia extracts showed the presence of alkaloids except in N. latifolia extract, flavonoids, sterols, triterpens, tanins, polyphenols, anthraquinons, saponins and terpenoids. CONCLUSION: These findings suggest that, the mixture of the two plant extracts showed an additive (synergetic effect) ovicidal effect and a slight larval mortality on L as compared to the effect of MCM As extract alone. These effects were due to the presence ao secondary metabolites identifies in the plant extracts. Thus, they may be used as possible «disinfectants¼ for soil transmitted nematodes.
[Mh] Termos MeSH primário: Annona/química
Anti-Helmínticos/farmacologia
Larva/efeitos dos fármacos
Nematoides/efeitos dos fármacos
Infecções por Nematoides/parasitologia
Extratos Vegetais/farmacologia
Rubiaceae/química
[Mh] Termos MeSH secundário: Animais
Camarões
Sinergismo Farmacológico
Estágios do Ciclo de Vida/efeitos dos fármacos
Medicina Tradicional Africana
Camundongos
Nematoides/crescimento & desenvolvimento
Compostos Fitoquímicos/análise
Compostos Fitoquímicos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Phytochemicals); 0 (Plant Extracts)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170813
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1908-8


  8 / 2091 MEDLINE  
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[PMID]:28629407
[Au] Autor:Bisi-Johnson MA; Obi CL; Samuel BB; Eloff JN; Okoh AI
[Ad] Endereço:Department of Microbiology, Obafemi Awolowo University, Ile-Ife, Nigeria. jumokade@yahoo.co.uk.
[Ti] Título:Antibacterial activity of crude extracts of some South African medicinal plants against multidrug resistant etiological agents of diarrhoea.
[So] Source:BMC Complement Altern Med;17(1):321, 2017 Jun 19.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: This study evaluated the antibacterial activity of some plants used in folklore medicine to treat diarrhoea in the Eastern Cape Province, South Africa. METHODS: The acetone extracts of Acacia mearnsii De Wild., Aloe arborescens Mill., A. striata Haw., Cyathula uncinulata (Schrad.) Schinz, Eucomis autumnalis (Mill.) Chitt., E. comosa (Houtt.) Wehrh., Hermbstaedtia odorata (Burch. ex Moq.) T.Cooke, Hydnora africana Thunb, Hypoxis latifolia Wight, Pelargonium sidoides DC, Psidium guajava L and Schizocarphus nervosus (Burch.) van der Merwe were screened against Staphylococcus aureus, Escherichia coli, Enterococcus faecalis, multi-resistant Salmonella enterica serovar Isangi, S. typhi, S. enterica serovar Typhimurium, Shigella flexneri type 1b and Sh. sonnei phase II. A qualitative phytochemical screening of the plants extracts was by thin layer chromatography. Plants extracts were screened for antibacterial activity using serial dilution microplate technique and bioautography. RESULTS: The TLC fingerprint indicated the presence of terpenoids and flavonoids in the herbs. Most of the tested organisms were sensitive to the crude acetone extracts with minimum inhibitory concentration (MIC) values ranging from 0.018-2.5 mg/mâ„“. Extracts of A. striata, C. uncinulata, E. autumnalis and P. guajava were more active against enteropathogens. S. aureus and Sh. flexneri were the most sensitive isolates to the crude extracts but of significance is the antibacterial activity of A. arborescens and P. guajava against a confirmed extended spectrum betalactamase positive S. enterica serovar Typhimurium. CONCLUSION: The presence of bioactive compounds and the antibacterial activity of some of the selected herbs against multidrug resistant enteric agents corroborate assertions by traditional healers on their efficacies.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Bactérias/efeitos dos fármacos
Infecções Bacterianas/tratamento farmacológico
Diarreia/tratamento farmacológico
Diarreia/microbiologia
Farmacorresistência Bacteriana Múltipla
Extratos Vegetais/farmacologia
Plantas Medicinais/química
[Mh] Termos MeSH secundário: Antibacterianos/isolamento & purificação
Bactérias/genética
Bactérias/isolamento & purificação
Infecções Bacterianas/microbiologia
Seres Humanos
Medicina Tradicional Africana
Testes de Sensibilidade Microbiana
África do Sul
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1802-4


  9 / 2091 MEDLINE  
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[PMID]:28586268
[Au] Autor:Morris C
[Ad] Endereço:a Department of Sociology and Anthropology , George Mason University , Fairfax , Virginia , USA.
[Ti] Título:Biopolitics and Boundary Work in South Africa's Sutherlandia Clinical Trial.
[So] Source:Med Anthropol;36(7):685-698, 2017 Oct.
[Is] ISSN:1545-5882
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Between 2008 and 2011, South African and American investigators carried out a randomized controlled trial to assess the safety and efficacy of an African traditional medicine in South Africans who were HIV-seropositive but asymptomatic. The medicine was derived from Sutherlandia frutescens, a plant endemic to and widely used to stimulate immune function by people across southern Africa. In this article, I report on the cross-cultural challenges generated by trial investigators' transformation of Sutherlandia into a clinical trial substance and a potential "treatment gap" therapy for persons with HIV. While Sutherlandia is in many respects an unusual addition to evidence-based medicine, it is also familiar in this context-especially in the manner the therapy was biopolitically imagined by trial investigators, and in terms of the indeterminacy the therapy produced.
[Mh] Termos MeSH primário: Fármacos Anti-HIV/uso terapêutico
Fabaceae/química
Infecções por HIV
Medicina Tradicional Africana
Extratos Vegetais/uso terapêutico
Ensaios Clínicos Controlados Aleatórios como Assunto
[Mh] Termos MeSH secundário: Antropologia Médica
Comparação Transcultural
Infecções por HIV/tratamento farmacológico
Infecções por HIV/etnologia
Seres Humanos
Política
África do Sul/etnologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-HIV Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170607
[St] Status:MEDLINE
[do] DOI:10.1080/01459740.2017.1337117


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[PMID]:28573252
[Au] Autor:Belayachi L; Aceves-Luquero C; Merghoub N; de Mattos SF; Amzazi S; Villalonga P; Bakri Y
[Ad] Endereço:Biochemistry, Immunology Laboratory, Faculty of Sciences, Mohammed V-Agdal University, Rabat, Morocco.
[Ti] Título:INDUCTION OF CELL CYCLE ARREST AND APOPTOSIS BY ORMENIS ERIOLEPIS A MORROCAN ENDEMIC PLANT IN VARIOUS HUMAN CANCER CELL LINES.
[So] Source:Afr J Tradit Complement Altern Med;14(2):356-373, 2017.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: (Asteraceae) is an endemic Moroccan subspecies, traditionally named "Hellala" or "Fergoga". It's usually used for its hypoglycemic effect as well as for the treatment of stomacal pain. As far as we know, there is no scientific exploration of anti tumoral activity of extracts. MATERIALS AND METHODS: In this regard, we performed a screening of organic extracts and fractions in a panel of both hematological and solid cancer cell lines, to evaluate the potential anti tumoral activity and to elucidate the respective mechanisms that may be responsible for growth arrest and cell death induction. The plant was extracted using organic solvents, and four different extracts were screened on Jurkat, Jeko-1, TK-6, LN229, SW620, U2OS, PC-3 and NIH3T3 cells. RESULTS: Cell viability assays revealed that, the IC50 values were (11,63±5,37µg/ml) for Jurkat, (13,33±1,67µg/ml) for Jeko-1, (41,67±1,98µg/ml) for LN229 and (19,31±4,88µg/ml) for PC-3 cells upon treatment with Oe-DF and Oe-HE respectively. Both the fraction and extract exhibited no effects on TK6 and NIH3T3. Cytometry analysis accompanied by DNA damage signaling protein levels monitoring (p-H2A.X), showed that both the Dichloromethane Fraction and Hexanic extract induce DNA double stranded breaks (DSBs) accompanied by cell cycle arrest in G1 (Jurkat, Jeko -1 and LN22) and G2/M (PC-3) phases which is agreed with the caspase activity observed. Additional experiments with selective inhibitors of stress and survival pathways (JNK, MAPK, Rho, p53, and JAK3) indicated that none of these pathways was significantly involved in apoptosis induction. The bioactive compound analysis by CG/MS indicated that the major compounds in Oe-DF were: Linoleic Acid (15,89%), Podophyllotoxin (17,89%) and Quercetin (22,95%). For Oe-HE the major molecules were: Linoleic Acid (9,76%), α-curcumene (7,07%), α-bisabolol (5,49%), Campesterol (4,41%), Stigmasterol (14,08%) and ß-sitosterol (7,49%). CONCLUSION: Our data suggest that bioactive compounds present in show significant anti proliferative activity inducing cell cycle arrest and cell death operating through apoptosis pathway.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/uso terapêutico
Apoptose
Asteraceae/química
Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
Neoplasias/tratamento farmacológico
Fitoterapia
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/farmacologia
Caspases/metabolismo
Ciclo Celular
Linhagem Celular Tumoral
Fragmentação do DNA
Seres Humanos
Células Jurkat
Medicina Tradicional Africana
Camundongos
Marrocos
Células NIH 3T3
Neoplasias/metabolismo
Compostos Fitoquímicos/farmacologia
Compostos Fitoquímicos/uso terapêutico
Extratos Vegetais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Phytochemicals); 0 (Plant Extracts); EC 3.4.22.- (Caspases)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v14i2.37



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