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Pesquisa : E02.190.488.585 [Categoria DeCS]
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[PMID]:29202775
[Au] Autor:Nguyen MT; Ho-Huynh TD
[Ad] Endereço:Molecular Genetics and Genomics Research Group, Cancer Research Laboratory, University of Science, VNU-HCM, Building B6.1, Dong Hoa Village, Di An District, Binh Duong Province, Vietnam.
[Ti] Título:Nam Dia long, a Vietnamese folk formula, induces apoptosis in MCF-7 cells through various mechanisms of action.
[So] Source:BMC Complement Altern Med;17(1):522, 2017 Dec 04.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The holistic approach of traditional medicine renders the identification of its mechanisms of action difficult. Microarray technology provides an efficient way to analyze the complex genome-wide gene expression of cells treated with mixtures of medicinal ingredients. We performed transcriptional profiling of MCF-7 cells treated with Nam Dia Long (NDL), a Vietnamese traditional formula, to explore the mechanism of action underlying the apoptosis inducing effect of this formula reported in a previous study. METHODS: MCF-7 cells were treated with aqueous extracts of NDL at the IC concentration for 24, 36 and 48 h. Total RNAs at 24 h and 48 h were subsequently extracted, reverse transcribed and submitted to microarray expression profiling using the Human HT-12 v4.0 Expression Bead Chip (Illumina). Functional analyses were performed using the Database for Annotation, Visualization and Integrated Discovery and the Ingenuity Pathways Analysis. The expression level from selected genes at the three time points were assessed by quantitative real-time RT-PCR and Western blot. RESULTS: Fifty-four and 601 genes were differentially expressed at 24 and 48 h of NDL treatment, respectively. Genes with altered expression at 24 h were mostly involved in cell responses to xenobiotic stress whereas genes differentially expressed at 48 h were related to endoplasmic reticulum stress, DNA damage and cell cycle control. Apoptosis of NDL treated MCF-7 cells resulted from a combination of different mechanisms including the intrinsic and extrinsic pathways, cell cycle arrest- and oxidative stress-related cell death. CONCLUSION: NDL elicited a two-stage response in MCF-7 treated cells with apoptosis as the ultimate result. The various mechanisms inducing apoptosis reflected the complexity of the formula composition.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Apoptose/efeitos dos fármacos
Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos
Medicina Tradicional do Leste Asiático
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Neoplasias da Mama
Feminino
Perfilação da Expressão Gênica
Seres Humanos
Células MCF-7
Análise de Sequência com Séries de Oligonucleotídeos
Transcriptoma/efeitos dos fármacos
Vietnã
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-2027-2


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[PMID]:28480440
[Au] Autor:Kameyama A; Toda K
[Ad] Endereço:Department of Endodontics and Clinical Cariology, Tokyo Dental College, Chiba, JAPAN.
[Ti] Título:SURVEY OF DENTAL STUDENTS' ATTITUDE REGARDING ORIENTAL MEDICINE/COMPLEMENTARY AND ALTERNATIVE MEDICINE: COMPARISON BETWEEN TWO JAPANESE DENTAL SCHOOLS.
[So] Source:Afr J Tradit Complement Altern Med;14(3):287-295, 2017.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The present study aimed to examine the impact of "curricula for undergraduate education in oriental medicine (OM)/complementary and alternative medicine (CAM)" on student awareness of OM. A questionnaire survey was conducted involving the Nagasaki University School of Dentistry (NUSD), a university that implements education in OM as part of its undergraduate curriculum, and Tokyo Dental College (TDC), which does not teach OM. MATERIALS AND METHODS: The third- and fifth-year students of both NUSD and TDC underwent the anonymous questionnaire survey, which included questions regarding their knowledge of OM and CAM, interests in these subjects, and their opinions on the necessity of teaching OM in the undergraduate dental education, and the results were collected for analysis. RESULTS: Whereas 33% of 5 year NUSD students had knowledge of OM/CAM was 33%, only 10% of 5 year TDC students reported knowledge on the subject. 69% of 5 year NUSD students interested in OM/CAM, while 5 year TDC students who interest them were only 45%. Although 77% of 5 year NUSD students were in favor of OM education implemented in the Faculty of Dentistry, the percentages of TDC students of that were smaller (46% in 3 year and 48% in 5 year). Whereas 26% of 5 year TDC students did not recognize the necessity of oriental medicine education, only one 5 year NUSD student (2%) did not so. CONCLUSION: Introduction of education in OM in the undergraduate dental education program helps students to increase their interests in dental clinical applications.
[Mh] Termos MeSH primário: Atitude do Pessoal de Saúde
Terapias Complementares/psicologia
Educação em Odontologia/métodos
Medicina Tradicional do Leste Asiático/psicologia
Estudantes de Odontologia/psicologia
[Mh] Termos MeSH secundário: Terapias Complementares/educação
Currículo
Educação de Graduação em Medicina/métodos
Feminino
Conhecimentos, Atitudes e Prática em Saúde
Seres Humanos
Japão
Masculino
Faculdades de Odontologia
Inquéritos e Questionários
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170815
[Lr] Data última revisão:
170815
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v14i3.30


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[PMID]:28284791
[Au] Autor:Chassagne F; Deharo E; Punley H; Bourdy G
[Ad] Endereço:UMR 152 Pharmadev, Université de Toulouse, IRD, UPS, France. Electronic address: francois.chassagne@ird.fr.
[Ti] Título:Treatment and management of liver diseases by Khmer traditional healers practicing in Phnom Penh area, Cambodia.
[So] Source:J Ethnopharmacol;202:38-53, 2017 Apr 18.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Liver disorders are a major health problem in Cambodia, where some patients prefer to seek treatment from traditional healers. The aim of the study was to document the knowledge and practices of these healers in four Southern Cambodian provinces. MATERIALS AND METHODS: An ethnopharmacological survey was carried out from September 2015 to January 2016 in Cambodian urban and rural areas. Thirty-three Khmer traditional healers (KTH) were interviewed using a semi-structured questionnaire including socio-demographic data, healer's formation and their professional practice conditions, perception of liver diseases (types and causes of liver disorders, diagnostic methods and symptoms of liver problems), dietary recommendations given to patients, and herbal remedies used to treat them. For each medicinal plant mentioned in herbal remedies, the local name, part of the plant, mode of preparation and administration, and their properties, according to the healers, were recorded. The plants mentioned by the traditional therapists were collected and later identified by specialists. RESULTS: Different types of liver disease are identified by the healers, and diagnosis was mostly based on reading medical records, and by observing the yellow discoloration of the skin and eyes. A total of 42 herbal remedies including 83 medicinal plants belonging to 40 families were mentioned for treating liver disorders. The most predominant families were Leguminosae and Poaceae. Among the plants reported, Cananga latifolia, Andrographis paniculata, Smilax aff. glabra, Gomphrena celosioides, Passiflora foetida and Physalis minima were the most cited species. A large part of the herbal remedies used were multi-ingredient recipes, and were prepared mainly by a decoction administered orally. Plants are combined in multi-ingredient recipes, and selected on the basis of their properties (trocheak, psah, somrap mé rok, ktchol) which originate from Khmer medical concepts. Most of the plants used by healers have a wide ethnobotanical use for liver disorders, and have been studied for their hepatoprotective activity and related activities on the liver. CONCLUSION: In the diagnosis and treatment of liver diseases, KTH have incorporated biomedical concepts and new practices, which suggest that they could be defined as neotraditional healers. Medicinal plants constitute the core of traditional medicine practice by these healers, and these plants play a very important role in the health care of people with liver problems in Cambodia. Therefore, more attention should be paid to the integration of healers in national health care programs for the development of combined therapies. Furthermore, two plant species (i.e. Cananga latifolia and Willughbeia edulis) were found to be widely used for treating liver disorders in our survey, and should be studied for their pharmacological potential for liver problems.
[Mh] Termos MeSH primário: Hepatopatias/terapia
Medicina Tradicional do Leste Asiático
[Mh] Termos MeSH secundário: Camboja
Dieta
Gerenciamento Clínico
Etnofarmacologia
Seres Humanos
Hepatopatias/diagnóstico
Fitoterapia
Preparações de Plantas/uso terapêutico
Plantas Medicinais/classificação
Fatores Socioeconômicos
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Preparations)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170824
[Lr] Data última revisão:
170824
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170313
[St] Status:MEDLINE


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[PMID]:28208738
[Au] Autor:Matsubara Y; Matsumoto T; Sekiguchi K; Koseki J; Kaneko A; Yamaguchi T; Kurihara Y; Kobayashi H
[Ad] Endereço:Tsumura Research Laboratories, Tsumura & Co., Ibaraki 300-1192, Japan. matsubara_yousuke@mail.tsumura.co.jp.
[Ti] Título:Oral Administration of the Japanese Traditional Medicine Keishibukuryogan-ka-yokuinin Decreases Reactive Oxygen Metabolites in Rat Plasma: Identification of Chemical Constituents Contributing to Antioxidant Activity.
[So] Source:Molecules;22(2), 2017 Feb 08.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Insufficient detoxification and/or overproduction of reactive oxygen species (ROS) induce cellular and tissue damage, and generated reactive oxygen metabolites become exacerbating factors of dermatitis. Keishibukuryogan-ka-yokuinin (KBGY) is a traditional Japanese medicine prescribed to treat dermatitis such as acne vulgaris. Our aim was to verify the antioxidant properties of KBGY, and identify its active constituents by blood pharmacokinetic techniques. Chemical constituents were quantified in extracts of KBGY, crude components, and the plasma of rats treated with a single oral administration of KBGY. Twenty-three KBGY compounds were detected in plasma, including gallic acid, prunasin, paeoniflorin, and azelaic acid, which have been reported to be effective for inflammation. KBGY decreased level of the diacron-reactive oxygen metabolites (d-ROMs) in plasma. ROS-scavenging and lipid hydroperoxide (LPO) generation assays revealed that gallic acid, 3- -methylgallic acid, (+)-catechin, and lariciresinol possess strong antioxidant activities. Gallic acid was active at a similar concentration to the maximum plasma concentration, therefore, our findings indicate that gallic acid is an important active constituent contributing to the antioxidant effects of KBGY. KBGY and its active constituents may improve redox imbalances induced by oxidative stress as an optional treatment for skin diseases.
[Mh] Termos MeSH primário: Antioxidantes/administração & dosagem
Medicamentos de Ervas Chinesas/administração & dosagem
Medicina Tradicional do Leste Asiático
Espécies Reativas de Oxigênio/sangue
[Mh] Termos MeSH secundário: Administração Oral
Animais
Antioxidantes/química
Antioxidantes/farmacocinética
Cromatografia Líquida
Medicamentos de Ervas Chinesas/química
Medicamentos de Ervas Chinesas/farmacocinética
Cromatografia Gasosa-Espectrometria de Massas
Masculino
Estresse Oxidativo/efeitos dos fármacos
Compostos Fitoquímicos/química
Extratos Vegetais/administração & dosagem
Extratos Vegetais/química
Extratos Vegetais/farmacocinética
Ratos
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Drugs, Chinese Herbal); 0 (Phytochemicals); 0 (Plant Extracts); 0 (Reactive Oxygen Species); 0 (keishibukuryogan)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE


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[PMID]:28198055
[Au] Autor:Bae K; Park JH; Kim J; Cho CK; Oh B; Costa D; Lim S; Deng G; Yoo HS
[Ad] Endereço:East-West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University, Daejeon, Korea.
[Ti] Título:Traditional Oriental Herbal Medicine and Natural Killer Cells for Cancer Patients: A Systematic Review and Meta-analysis.
[So] Source:Phytother Res;31(4):519-532, 2017 Apr.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Traditional oriental herbal medicine (HM) is used by cancer patients to improve immunity. Natural killer (NK) cells are associated with development and progression of tumor and survival of cancer patients. This literature review examined randomized controlled trials (RCTs) in four electronic databases until October 2015 to evaluate the effects of oral HM on NK cells in cancer patients. Data were pooled and computed in a meta-analysis. The methodological quality was assessed according to the Cochrane risk of bias tool. Sixteen RCTs involving 1326 cancer patients were identified. Combination of HM and conventional treatment was associated with significantly higher level of NK cells compared with conventional cancer treatments (standardized mean difference, 1.218; 95% confidence interval 0.719-1.717; p < 0.001). Eight RCTs reported statistically significant improvements in the proportions or activity of NK cells in patient groups who received both HM and conventional treatment compared with patients who received conventional treatment alone, while eight RCTs reported no statistically significant differences between the two groups. Studies (n = 16) included in this review had insufficient quality of evidence with unclear (n = 1) and high (n = 15) values of the risk of bias. Although traditional oriental HM may have the positive effects on preserving the level of NK cells in cancer patients receiving conventional treatments, current evidence is inconclusive because of lack of high-quality evidence. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Imunoterapia/métodos
Células Matadoras Naturais/metabolismo
Medicina Tradicional do Leste Asiático/métodos
Neoplasias/tratamento farmacológico
[Mh] Termos MeSH secundário: Seres Humanos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170503
[Lr] Data última revisão:
170503
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170216
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5781


  6 / 3378 MEDLINE  
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[PMID]:28105862
[Au] Autor:Carrieri R; Manco R; Sapio D; Iannaccone M; Fulgione A; Papaianni M; de Falco B; Grauso L; Tarantino P; Ianniello F; Lanzotti V; Lahoz E; Capparelli R
[Ad] Endereço:a Dipartimento di Colture Industriali , Consiglio per la Ricerca in Agricoltura e l'Analisi dell'Economia Agraria (CREA) , Caserta , Italy.
[Ti] Título:Structural data and immunomodulatory properties of a water-soluble heteroglycan extracted from the mycelium of an Italian isolate of Ganoderma lucidum.
[So] Source:Nat Prod Res;31(18):2119-2125, 2017 Sep.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Mushrooms produce a wide range of bioactive polysaccharides, different from each other in chemical structure and biological effects. In the last years, the idea to develop functional foods or drugs containing fungal polysaccharides is attracting great attention. Fruiting bodies of Basidiomycetes Ganoderma lucidum are commonly used in Oriental medicine to treat several disorders. G. lucidum polysaccharides - mainly ß-glucans and heteroglycans - have numerous biological properties such as antitumour and immunomodulatory activities. This report shows, by gene expression analyses and bioenergetic assays, immunomodulatory properties and capacity to improve glucose metabolism of a water-soluble heteroglycan extracted from mycelium of an Italian isolate of G. lucidum. The findings suggest the use of the heteroglycan as probiotic or ingredient in functional foods, being easy to produce and disperse in a food matrix thanks to its water-solubility. Heteroglycan could exert protective effects in pro-inflammatory conditions and benefits for people characterised by suppressed immune response.
[Mh] Termos MeSH primário: Polissacarídeos Fúngicos/química
Polissacarídeos Fúngicos/farmacologia
Glucanos/farmacologia
Fatores Imunológicos/farmacologia
Reishi/química
[Mh] Termos MeSH secundário: Linhagem Celular
Citocinas/genética
Avaliação Pré-Clínica de Medicamentos/métodos
Regulação da Expressão Gênica/efeitos dos fármacos
Glucanos/química
Glucose/metabolismo
Seres Humanos
Fatores Imunológicos/química
Itália
Espectroscopia de Ressonância Magnética
Medicina Tradicional do Leste Asiático
Micélio/química
Solubilidade
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Fungal Polysaccharides); 0 (Glucans); 0 (Immunologic Factors); 059QF0KO0R (Water); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1278593


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[PMID]:28085113
[Au] Autor:Fung HY; Lang Y; Ho HM; Wong TL; Ma DL; Leung CH; Han QB
[Ad] Endereço:School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. 15485862@life.hkbu.edu.hk.
[Ti] Título:Comprehensive Quantitative Analysis of 32 Chemical Ingredients of a Chinese Patented Drug Sanhuang Tablet.
[So] Source:Molecules;22(1), 2017 Jan 12.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Sanhuang Tablet (SHT) is a Chinese patented drug commonly used for the treatment of inflammations of the respiratory tract, gastrointestinal tract, and skin. It contains a special medicinal composition including the single compound berberine hydrochloride, extracts of Scutellariae Radix and Rhei Radix et Rhizoma, as well as the powder of Rhei Radix et Rhizoma. Despite advances in analytical techniques, quantitative evaluation of a Chinese patented drug like SHT remains a challenge due to the complexity of its chemical profile. In this study, ultra-high performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) was used to simultaneously quantify 29 non-sugar small molecule components of SHT (11 flavonoids, two isoflavonoids, one flavanone, five anthraquinones, two dianthranones, five alkaloids, two organic acids and one stilbene). Three major saccharide components, namely fructose, glucose, and sucrose, were also quantitatively determined using high performance liquid chromatography-charged aerosol detector (HPLC-CAD) on an Asahipak NH2P-50 4E amino column. The established methods were validated in terms of linearity, sensitivity, precision, accuracy, and stability, and then successfully applied to analyze 27 batches of commercial SHT products. A total of up to 57.61% ( / ) of SHT could be quantified, in which the contents of the determined non-saccharide small molecules varied from 5.91% to 16.83% ( / ) and three saccharides accounted for 4.41% to 48.05% ( / ). The results showed that the quality of the commercial products was inconsistent, and only four of those met Chinese Pharmacopoeia criteria.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/química
Inflamação/tratamento farmacológico
Comprimidos/química
[Mh] Termos MeSH secundário: Alcaloides/química
Alcaloides/isolamento & purificação
Cromatografia Líquida de Alta Pressão
Medicamentos de Ervas Chinesas/análise
Flavonoides/química
Flavonoides/isolamento & purificação
Seres Humanos
Inflamação/patologia
Medicina Tradicional do Leste Asiático
Rizoma/química
Scutellaria baicalensis/química
Comprimidos/análise
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Drugs, Chinese Herbal); 0 (Flavonoids); 0 (Tablets); 0 (sanhuang)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170114
[St] Status:MEDLINE


  8 / 3378 MEDLINE  
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[PMID]:28067853
[Au] Autor:Hamuti A; Li J; Zhou F; Aipire A; Ma J; Yang J; Li J
[Ad] Endereço:Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, 666 Shengli Road, Urumqi 830046, China. 13070411128@163.com.
[Ti] Título:Capparis spinosa Fruit Ethanol Extracts Exert Different Effects on the Maturation of Dendritic Cells.
[So] Source:Molecules;22(1), 2017 Jan 07.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:L. ( ) has been used as food and traditional medicine and shows anti-inflammatory and anti-oxidant activities. Here, we prepared the fruit ethanol extracts (CSEs) using different procedures and investigated the effects of CSE on the maturation of mouse bone marrow-derived dendritic cells (DCs) in the absence or presence of lipopolysaccharide (LPS). DC maturation and cytokine production were detected by flow cytometry and ELISA, respectively. We obtained three different CSEs and dissolved in water or DMSO, named CSE2W, CSEMW, CSE3W, CSE2D, CSEMD, and CSE3D, respectively. These CSEs showed different effects on DC maturation. CSEMW and CSEMD significantly increased the expressions of CD40, CD80, and CD86, in a dose-dependent manner. CSE2W and CSE2D also showed a modest effect on DC maturation, which enhanced the expression of CD40. CSE3W and CSE3D did not change DC maturation but suppressed LPS-induced DC maturation characterized by the decreased levels of CD40 and CD80. CSE3W and CSE3D also significantly inhibited the secretions of IL-12p40, IL-6, IL-1ß, and TNF-α induced by LPS. CSE3W further increased the level of IL-10 induced by LPS. Moreover, CSE3D suppressed LPS-induced DC maturation in vivo, which decreased the expressions of CD40 and CD80. These results suggested that CSE3W and CSE3D might be used to treat inflammatory diseases.
[Mh] Termos MeSH primário: Capparis/química
Diferenciação Celular/efeitos dos fármacos
Células Dendríticas/citologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antígeno B7-1/biossíntese
Antígeno B7-2/biossíntese
Células da Medula Óssea/citologia
Antígenos CD40/biossíntese
Células Dendríticas/efeitos dos fármacos
Ensaio de Imunoadsorção Enzimática
Etanol/metabolismo
Citometria de Fluxo
Frutas/metabolismo
Interleucina-10/secreção
Subunidade p40 da Interleucina-12/secreção
Interleucina-1beta/secreção
Interleucina-6/secreção
Lipopolissacarídeos
Medicina Tradicional do Leste Asiático
Camundongos
Camundongos Endogâmicos BALB C
Fator de Necrose Tumoral alfa/secreção
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (B7-1 Antigen); 0 (B7-2 Antigen); 0 (CD40 Antigens); 0 (IL10 protein, mouse); 0 (IL1B protein, mouse); 0 (Interleukin-12 Subunit p40); 0 (Interleukin-1beta); 0 (Interleukin-6); 0 (Lipopolysaccharides); 0 (Plant Extracts); 0 (Tumor Necrosis Factor-alpha); 0 (interleukin-6, mouse); 130068-27-8 (Interleukin-10); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170110
[St] Status:MEDLINE


  9 / 3378 MEDLINE  
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[PMID]:27991830
[Au] Autor:Hamaguchi T; Yoshino T; Horiba Y; Watanabe K
[Ad] Endereço:Center for Kampo Medicine, Keio University School of Medicine , Tokyo, Japan .
[Ti] Título:Goshajinkigan for Low Back Pain: An Observational Study.
[So] Source:J Altern Complement Med;23(3):208-213, 2017 Mar.
[Is] ISSN:1557-7708
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Low back pain (LBP) is a chronic condition. Although Western treatments are available, Kampo (traditional Japanese) medicine is widely prescribed and covered by health insurance in Japan. Goshajinkigan (GJG), a Kampo formula, is commonly used to treat LBP. However, cases we have occasionally been encountered in which GJG did not show the expected effects. Hence, the purpose of this retrospective study was to investigate patient factors important in developing the effects of GJG. METHODS: This was a retrospective observational study based at the Center for Kampo Medicine, Keio University Hospital. Data were retrieved from the medical records of 28 patients who visited our hospital between May 2008 and March 2013 and who received GJG for LBP. The patients were divided into responders and non-responders based on whether their LBP improved post treatment. The groups were compared with respect to daily GJG dose, incidence of spine disease, and side effects. RESULTS: Ten patients (responders) reported an improvement in LBP within 6 months. One patient experienced decreased appetite as a side effect. Nine patients reported no improvement (non-responders). The number of patients prescribed the usual daily dose of GJG (7.5 g) was significantly higher among responders than it was among non-responders (p = 0.023), and the number of patients with spine disease was significantly greater among non-responders than it was among responders (p = 0.020). The number of patients with spinal stenosis was significantly higher among non-responders than it was among responders (p = 0.011). Therefore, the usual daily dose of GJG provided significant relief of LBP, particularly in patients without any spine disease. CONCLUSIONS: Routine daily administration of GJG in patients without spine disease seems to lead to the effects of the product. However, further investigations using the above-mentioned parameters are needed to confirm these findings.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/uso terapêutico
Dor Lombar/tratamento farmacológico
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Japão
Masculino
Medicina Tradicional do Leste Asiático
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (gosha-jinki-gan)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161220
[St] Status:MEDLINE
[do] DOI:10.1089/acm.2016.0276


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[PMID]:27960066
[Au] Autor:Katayama Y; Marumo S; Shima H; Shirata M; Kawashima S; Kitajima T; Inoue D; Itotani R; Sakuramoto M; Fukui M
[Ad] Endereço:Department of Respiratory Medicine, Kitano Hospital, Tazuke Kofukai Medical Research Institute , Osaka, Japan .
[Ti] Título:Effectiveness of Shin'iseihaito in Asthmatic Patients with Upper Airway Diseases: A Retrospective Cohort Study.
[So] Source:J Altern Complement Med;23(2):121-125, 2017 Feb.
[Is] ISSN:1557-7708
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Severe asthma is often associated with sinonasal diseases. Shin'iseihaito is a Japanese traditional herbal medicine, which is used to treat rhinosinusitis. However, its effectiveness in the treatment of asthma has not been elucidated. OBJECTIVE: The aims of this study were to examine the effectiveness of Shin'iseihaito in asthmatic patients with upper airway disease and to identify the characteristics of responders. METHODS: The medical records were retrospectively analyzed of asthmatic patients concomitant with upper airway disease in the outpatient department who had been administered Shin'iseihaito at least once from September 2011 to February 2015. They were classified into responders and non-responders, and the differences in characteristics were compared between the two groups. RESULTS: Shin'iseihaito was effective in 21/40 (52.5%) patients. There was no significant difference between responders and non-responders with regard to age, sex, or age of asthma onset. However, the frequency of aspirin intolerance, the treatment step of asthma, and serum immunoglobulin E levels were significantly higher in responders than they were in non-responders (p = 0.022, p = 0.017, and p = 0.017, respectively). The frequency of occurrence of concomitant eosinophilic chronic rhinosinusitis was not significantly different in both groups. CONCLUSION: Shin'iseihaito could be a potential alternative for the treatment of asthma in patients with upper airway diseases.
[Mh] Termos MeSH primário: Asma/complicações
Asma/tratamento farmacológico
Medicina Tradicional do Leste Asiático/métodos
Pólipos Nasais/complicações
Preparações de Plantas/uso terapêutico
Sinusite/complicações
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Pico do Fluxo Expiratório
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Preparations)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161214
[St] Status:MEDLINE
[do] DOI:10.1089/acm.2016.0181



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