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  1 / 196 MEDLINE  
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[PMID]:28288330
[Au] Autor:Lu NH; Zhao HQ; Jing M; Liu X; Ren CZ; Liu XF; Liu JJ; Zhang YX
[Ad] Endereço:Gansu University of Chinese Medicine, Lanzhou 730000, People's Republic of China.
[Ti] Título:The pharmacodynamic active components study of Tibetan medicine Gentianopsis paludosa on ulcerative colitis fibrosis.
[So] Source:Int Immunopharmacol;46:163-169, 2017 May.
[Is] ISSN:1878-1705
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The current study focused on the pharmacodynamic activity components of Gentianopsis paludosa against ulcerative colitis (UC) fibrosis including symptoms of intestinal diarrhea and inflammatory. Trinitro-benzene-sulfonic acid induced UC model rats were gavaged with gradient polarity extracts respectively from ethanol-extract of Gentianopsis paludosa. Masson staining and qRT-PCR methods were respectively used to assess the degree of UC fibrosis and detect the mRNA expressions of collagen I, collagen III, a-smooth muscle actin (α-SMA) and E-cadherin in colon tissue. Separated by silica gel column chromatography, further screening was conducted until active components appeared. Infrared, nuclear magnetic resonance, mass spectroscopy and ultraviolet methods were applied to confirm active components' structures. The results indicated that the expression of collagen I, collagen III and α-SMA mRNA in the colon tissues of acetidin group rats was obviously depressed compared with control groups while E-cadherin displayed just opposite. Dyed in blue indicating UC fibrosis degree, the area of acetidin group was less than that other experimental groups. Four components: (1,8-Dihydroxy-3,7-Dimethoxyxanthones, 1-hydroxy-3,7,8-Trimethoxyxanthones, 1,7-Dihydroxy-3,8-Dimethoxyxanthones and 1-hydroxy-3,7-Dimethoxyxanthones), were obtained from acetidin group and all of which have a significant equivalence to Gentianopsis paludosa on the therapeutic effect of UC fibrosis. Our findings revealed the activity components for clinical application history of Gentianopsis paludosa and provided a preliminary foundation for further new drug research and exploitation.
[Mh] Termos MeSH primário: Colite Ulcerativa/tratamento farmacológico
Colo/efeitos dos fármacos
Medicina Tradicional Tibetana
Extratos Vegetais/farmacologia
Xantonas/farmacologia
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
China
Colite Ulcerativa/induzido quimicamente
Colo/patologia
Etanol/química
Fibrose
Gentianaceae/imunologia
Seres Humanos
Extratos Vegetais/química
Ratos
Ratos Wistar
Ácido Trinitrobenzenossulfônico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Xanthones); 3K9958V90M (Ethanol); 8T3HQG2ZC4 (Trinitrobenzenesulfonic Acid)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170620
[Lr] Data última revisão:
170620
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170314
[St] Status:MEDLINE


  2 / 196 MEDLINE  
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[PMID]:28065777
[Au] Autor:Cao WR; Ge JQ; Xie X; Fan ML; Fan XD; Wang H; Dong ZY; Liao ZH; Lan XZ; Chen M
[Ad] Endereço:College of Pharmaceutical Sciences, Key Laboratory on Luminescence and Real-Time Analysis (Ministry of Education), Southwest University, Chongqing 400715, PR China; TAAHC-SWU Medicinal Plant R&D Center, XiZang Agriculture and Animal Husbandry College, Nyingchi, Tibet 860000, PR China.
[Ti] Título:Protective effects of petroleum ether extracts of Herpetospermum caudigerum against α-naphthylisothiocyanate-induced acute cholestasis of rats.
[So] Source:J Ethnopharmacol;198:139-147, 2017 Feb 23.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: The ripe seeds of Herpetospermum caudigerum have been used in Tibetan folk medicine for treatment of bile or liver diseases including jaundice, hepatitis, intumescences or inflammation. Previously reports suggested that the seed oil and some lignans from H. caudigerum exhibited protective effects against carbon tetrachloride (CCl )-induced hepatic damage in rats, which may be related to their free radical scavenging effect. However, the protective effect of H. caudigerum against cholestasis is still not revealed. The aim of the present study was to investigate the pharmacological effect and the chemical constituents of the petroleum ether extract (PEE) derived from H. caudigerum against α-naphthylisothiocyanate (ANIT)-induced acute cholestasis in rats. MATERIALS AND METHODS: Male cholestatic Sprague-Dawley (SD) rats induced by ANIT (60mg/kg) were orally administered with PEE (350, 700 and 1400mg/kg). Levels of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), γ-Glutamyl transpeptidase (γ-GTP), total bilirubin (TBIL), direct bilirubin (DBIL) and total bile acid (TBA), as well as bile flow, and histopathological assay were evaluated. Hepatic malondialdehyde (MDA), myeloperoxidase (MPO), superoxide dismutase (SOD), glutathione S-transferase (GST), and nitric monoxide (NO) in liver were measured to explore the possible protective mechanisms. Phytochemical analysis of PEE was performed by gas chromatography-mass spectrometer (GC-MS). RESULTS: PEE have exhibited significant and dose-dependent protective effect on ANIT-induced liver injury by reduce the increases in serum levels of ALT, AST, ALP, γ-GTP, TBIL, DBIL and TBA, restore the bile flow in cholestatic rats, and reduce the severity of the pathological tissue damage induced by ANIT. Hepatic MDA, MPO and NO contents in liver tissue were reduced, while SOD and GST activities were elevated in liver tissue. 49 compounds were detected and 39 of them were identified by GC-MS analysis, in which long-chain fatty acids were the main constituents. CONCLUSIONS: PEE exhibited a dose-dependently protective effect on ANIT-induced liver injury in cholestatic rats with the potential mechanism of attenuated oxidative stress in the liver tissue, and the possible active compounds were long-chain fatty acids.
[Mh] Termos MeSH primário: 1-Naftilisotiocianato/toxicidade
Colestase/tratamento farmacológico
Cucurbitaceae
Medicina Tradicional Tibetana
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Doença Aguda
Animais
Colestase/induzido quimicamente
Colestase/metabolismo
Cucurbitaceae/química
Relação Dose-Resposta a Droga
Fígado/efeitos dos fármacos
Fígado/patologia
Masculino
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/análise
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 551-06-4 (1-Naphthylisothiocyanate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170110
[St] Status:MEDLINE


  3 / 196 MEDLINE  
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[PMID]:27937009
[Au] Autor:Shen XF; Zeng Y; Li JC; Tang C; Zhang Y; Meng XL
[Ad] Endereço:a College of Pharmacy , Chengdu University of Traditional Chinese Medicine , Chengdu , Sichuan , China.
[Ti] Título:The anti-arthritic activity of total glycosides from Pterocephalus hookeri, a traditional Tibetan herbal medicine.
[So] Source:Pharm Biol;55(1):560-570, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Pterocephalus hookeri (C. B. Clarke) Hock., a traditional Tibetan herbal medicine rich in glycosides, has been used to treat several diseases including rheumatoid arthritis. OBJECTIVE: To evaluate the anti-arthritic activity of total glycosides from P. hookeri, and its possible mechanisms of action. MATERIALS AND METHODS: Anti-arthritic activity of total glycosides from P. hookeri (oral administration for 30 days at 14-56 mg/kg) was evaluated using paw swelling, arthritis scores and histopathological measurement in adjuvant-induced arthritis (AA) Sprague-Dawley rats. The NF-κB p65 expression in synovial tissues, and serum superoxide dismutase (SOD) activity, malondialdehyde (MDA) and nitric oxide (NO) levels was measured in AA rats, respectively. Further assessment of anti-inflammatory and analgesic activities of these glycosides were carried out using inflammation and hyperalgesia models induced by xylene, carrageenan, agar and acetic acid, respectively. RESULTS: Total glycosides (56 mg/kg) decreased the paw swelling (38.0%, p < 0.01), arthritis scores (25.3%, p < 0.01) and synovial inflammation in AA rats. The glycosides significantly (p < 0.05-0.01) attenuated the inflammation induced by xylene, carrageenan, acetic acid and agar, increased the pain threshold in acetic acid-induced writhing in mice and mechanical stimuli-induced hyperalgia in AA rats. The glycosides (14, 28, 56 mg/kg) also suppressed the NF-κB p65 expression (33.1-78.2%, p < 0.05-0.01), reduced MDA (21.3-35.9%, p < 0.01) and NO (20.3-32.4%, p < 0.05-0.01) levels, respectively, enhanced the SOD activity (7.8%, p < 0.05) at 56 mg/kg in AA rats. DISCUSSION AND CONCLUSION: Our findings confirmed the anti-arthritic property of the total glycosides from P. hookeri, which may be attributed to its inhibition on NF-κB signalling and oxidative stress.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Artrite Experimental/tratamento farmacológico
Caprifoliaceae/química
Glicosídeos/farmacologia
Articulações/efeitos dos fármacos
Preparações de Plantas/farmacologia
[Mh] Termos MeSH secundário: Analgésicos/isolamento & purificação
Analgésicos/farmacologia
Animais
Anti-Inflamatórios/isolamento & purificação
Antioxidantes/isolamento & purificação
Antioxidantes/farmacologia
Artrite Experimental/induzido quimicamente
Artrite Experimental/metabolismo
Artrite Experimental/patologia
Comportamento Animal/efeitos dos fármacos
Biomarcadores/sangue
Relação Dose-Resposta a Droga
Edema/induzido quimicamente
Edema/prevenção & controle
Feminino
Adjuvante de Freund
Glicosídeos/isolamento & purificação
Hiperalgesia/induzido quimicamente
Hiperalgesia/fisiopatologia
Hiperalgesia/prevenção & controle
Mediadores da Inflamação/sangue
Articulações/metabolismo
Articulações/patologia
Masculino
Malondialdeído/sangue
Medicina Tradicional Tibetana
Camundongos
Óxido Nítrico/sangue
Limiar da Dor/efeitos dos fármacos
Fitoterapia
Preparações de Plantas/isolamento & purificação
Plantas Medicinais
Ratos Sprague-Dawley
Superóxido Dismutase/sangue
Fatores de Tempo
Fator de Transcrição RelA/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Biomarkers); 0 (Glycosides); 0 (Inflammation Mediators); 0 (Plant Preparations); 0 (Rela protein, rat); 0 (Transcription Factor RelA); 31C4KY9ESH (Nitric Oxide); 4Y8F71G49Q (Malondialdehyde); 9007-81-2 (Freund's Adjuvant); EC 1.15.1.1 (Superoxide Dismutase)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE


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[PMID]:27738246
[Au] Autor:Sallon S; Dory Y; Barghouthy Y; Tamdin T; Sangmo R; Tashi J; Yangdon S; Yeshi T; Sadutshang T; Rotenberg M; Cohen E; Harlavan Y; Sharabi G; Bdolah-Abram T
[Ad] Endereço:1 The Louis L Borick Natural Medicine Research Center, Hadassah Medical Organization, Jerusalem 91120, Israel.
[Ti] Título:Is mercury in Tibetan Medicine toxic? Clinical, neurocognitive and biochemical results of an initial cross-sectional study.
[So] Source:Exp Biol Med (Maywood);242(3):316-332, 2017 Feb.
[Is] ISSN:1535-3699
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Mercury an important therapeutic substance in Tibetan Medicine undergoes complex "detoxification" prior to inclusion in multi-ingredient formulas. In an initial cross-sectional study, patients taking Tibetan Medicine for various conditions were evaluated for mercury toxicity. Two groups were identified: Group 1, patients taking " Tsothel" the most important detoxified mercury preparation and Group 2, patients taking other mercury preparations or mercury free Tibetan Medicine. Atomic fluorescence spectrometry of Tibetan Medicine showed mercury consumption 130 µg/kg/day (Group 1) and 30 µg/kg/day (Group 2) ( P ≤ 0.001), levels above EPA (RfDs) suggested threshold (0.3 µg/kg /day) for oral chronic exposure. Mean duration of Tibetan Medicine treatment was 9 ± 17 months (range 3-116) (Group 1) and 5 ± 1.96 months (range 1-114) (Group 2) (NS) with cumulative days of mercury containing Tibetan Medicine, 764 days ± 1214 (range 135-7330) vs. 103 days ± 111 (range 0-426), respectively ( P ≤ 0.001). Comparison of treatment groups with healthy referents (Group 3) not taking Tibetan Medicine showed no significant differences in prevalence of 23 non-specific symptoms of mercury toxicity, abnormal neurological, cardiovascular and dental findings and no correlation with mercury exposure variables; consumption, cumulative treatment days, blood/ urine Hg. Liver and renal function tests in treatment groups were not significantly increased compared to referents, with mean urine Beta Microglobulin within the normal range and not significantly associated with Hg exposure variables after correcting for confounding variables. Neurocognitive testing showed no significant intergroup differences for Wechsler Memory Scale, Grooved Pegboard, Visual Retention, but Group1 scores were better for Mini-Mental, Brief Word Learning, Verbal Fluency after correcting for confounding variables. These results suggest mercury containing Tibetan Medicine does not have appreciable adverse effects and may exert a possible beneficial effect on neurocognitive function. Since evidence of mercury as a toxic heavy metal, however, is well known, further analysis of literature on mercury use in other Asian traditional systems is highly suggested prior to further studies.
[Mh] Termos MeSH primário: Cognição/efeitos dos fármacos
Medicina Tradicional Tibetana/efeitos adversos
Intoxicação do Sistema Nervoso por Mercúrio/diagnóstico
Mercúrio/toxicidade
Mercúrio/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Estudos Transversais
Feminino
Seres Humanos
Índia
Masculino
Mercúrio/sangue
Mercúrio/urina
Intoxicação do Sistema Nervoso por Mercúrio/sangue
Intoxicação do Sistema Nervoso por Mercúrio/urina
Espectrometria de Fluorescência
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
FXS1BY2PGL (Mercury)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170801
[Lr] Data última revisão:
170801
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161015
[St] Status:MEDLINE
[do] DOI:10.1177/1535370216672748


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[PMID]:27481300
[Au] Autor:Pradhan BK
[Ad] Endereço:Sikkim Biodiversity Board, Forests, Environment and Wildlife Management Department, Government of Sikkim, Forest Secretariat, Deorali, Sikkim, India.
[Ti] Título:Caterpillar Mushroom, Ophiocordyceps sinensis (Ascomycetes): A Potential Bioresource for Commercialization in Sikkim Himalaya, India.
[So] Source:Int J Med Mushrooms;18(4):337-46, 2016.
[Is] ISSN:1940-4344
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ophiocordyceps sinensis has a long history of use in Tibetan traditional medicine and traditional Chinese medicine as a powerful tonic and aphrodisiac. The species is inextricably linked to the trade of medicinal and aromatic plants in East Asia. Its demand has increased substantially in the international market, and its collection and trade have significantly improved the socioeconomic status of the people in some regions. Nonetheless, in Sikkim this resource is still untapped formally, but it is traded illegally. Formal legalization and the community's involvement will ensure the conservation and sustainability of the species, as well as proper management of harvesting areas and monitoring of pressure on Yartsa Gunbu to exploit it.
[Mh] Termos MeSH primário: Conservação dos Recursos Naturais
Hypocreales/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Conservação dos Recursos Naturais/economia
Conservação dos Recursos Naturais/legislação & jurisprudência
Geografia
Hypocreales/isolamento & purificação
Medicina Tradicional Chinesa
Medicina Tradicional Tibetana
Siquim
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160803
[St] Status:MEDLINE
[do] DOI:10.1615/IntJMedMushrooms.v18.i4.70


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[PMID]:27400475
[Au] Autor:Kou Y; Li Y; Ma H; Li W; Li R; Dang Z
[Ti] Título:Uric acid lowering effect of Tibetan Medicine RuPeng15 powder in animal models of hyperuricemia.
[So] Source:J Tradit Chin Med;36(2):205-10, 2016 Apr.
[Is] ISSN:0255-2922
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate the influence of the Tibetan medicine RuPeng15 powder (RPP15) on uric acid levels, and explore its possible mechanisms of action in hyperuricemic animal models. METHODS: Hyperuricemic mice were generated by orally administering yeast extract paste twice daily (30 g/kg) for 8 days, to mimic human hyperuricemia induced by high-protein diets. Hyperuricemic rats were generated by intraperitoneal injection of 250 mg/kg potassium oxonate to each animal 1 h before the last oral administration of test compounds, which raised the serum uric acid level by inhibiting the decomposition of uric acid. Levels of uric acid and creatinine in serum and urine were detected by the phosphotungstic acid and picric acid methods respectively, and the activity of xanthine oxidase (XOD) was assayed using a commercial test kit. RESULTS: RPP15 (0.4, 0.8, 1.2 g/kg) significantly decreased the level of serum uric acid in healthy rats (P < 0.05). Furthermore, hyperuricemic rats treated with RPP15 (0.4, 0.8, 1.2 g/kg) had lower serum uric acid levels (P < 0.05), accompanied by lower urine uric acid (P < 0.05). For the hyperuricemic mice, the levels of uric acid in the serum decreased significantly (P < 0.05) and the activity of XOD in the liver was restored to normal levels after treatment with RPP15 (P < 0.05). CONCLUSION: RPP15 (0.4, 0.8, 1.2 g/kg) demonstrated an anti-hyperuricemic effect on both healthy and hyperuricemic animals, and the mechanism is most likely associated with inhibiting the activity of XOD.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/administração & dosagem
Hiperuricemia/tratamento farmacológico
Ácido Úrico/sangue
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Hiperuricemia/sangue
Hiperuricemia/metabolismo
Fígado/enzimologia
Masculino
Medicina Tradicional Tibetana
Ratos
Xantina Oxidase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 268B43MJ25 (Uric Acid); EC 1.17.3.2 (Xanthine Oxidase)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:161020
[Lr] Data última revisão:
161020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160713
[St] Status:MEDLINE


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[PMID]:27279447
[Au] Autor:Lei W; Zhang G; Wu G; Liu X
[Ad] Endereço:Laboratory of Cardiovascular Diseases, Guangdong Medical College, Zhanjiang, China; Food and Health Engineering Research Center of State Education Ministry, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
[Ti] Título:Cytological Characterization of Anamorphic Fungus Lecanicillium pui and Its Relationship with Chinese Caterpillar Mushroom, Ophiocordyceps sinensis (Ascomycetes).
[So] Source:Int J Med Mushrooms;18(1):75-81, 2016.
[Is] ISSN:1940-4344
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ophiocordyceps sinensis (syn. Cordyceps sinensis), one of the most valuable medicinal mushrooms, has great economic importance on the Tibetan Plateau. We isolated an anamorphic fungus Lecanicillium pui from natural O. sinensis specimens and found that the optimal temperature for its culture on potato dextrose agar media was 25°C. Cell ultrastructure in L. pui hyphae and spores was characterized by transmission electron microscopy, and it was observed that some primary organelles showed the typical fungal features. Five chemical elements were determined in this fungus and niobium was discovered for the first time even with trace amounts. A species-specific method, nested polymerase chain reaction, was established to investigate the colonization of this fungus. Thus, the extensive distribution of L. pui on O. sinensis, in the shape of hyphae or mycelia, suggested that it may have subtle and chronic effects on the growth of the O. sinensis teleomorphic stage. These findings provide a potential reference, in the view of microbial ecology, for the study on the occurrence and mechanism of development of O. sinensis.
[Mh] Termos MeSH primário: Cordyceps/classificação
Hypocreales/classificação
[Mh] Termos MeSH secundário: Cordyceps/genética
Cordyceps/crescimento & desenvolvimento
Cordyceps/ultraestrutura
DNA Fúngico/genética
Hifas
Hypocreales/genética
Hypocreales/crescimento & desenvolvimento
Hypocreales/ultraestrutura
Medicina Tradicional Tibetana
Microscopia Eletrônica de Transmissão
Reação em Cadeia da Polimerase
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Fungal)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160610
[St] Status:MEDLINE
[do] DOI:10.1615/IntJMedMushrooms.v18.i1.90


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[PMID]:27118685
[Au] Autor:Guo Q; Bai R; Zhao B; Feng X; Zhao Y; Tu P; Chai X
[Ad] Endereço:* Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, P.R. China.
[Ti] Título:An Ethnopharmacological, Phytochemical and Pharmacological Review of the Genus Meconopsis.
[So] Source:Am J Chin Med;44(3):439-62, 2016.
[Is] ISSN:0192-415X
[Cp] País de publicação:Singapore
[La] Idioma:eng
[Ab] Resumo:The Meconopsis plants (Chinese: ), belonging to the family Papaveraceae, have been used as traditional Tibetan medicine (TTM) for thousands of years. Meconopsis has the effects of clearing heat, reducing swelling, and easing pain, and is mainly prescribed for heat syndromes, hepatitis, pneumonia, and pain in joints. Phytochemical studies have revealed the presence of major isoquinoline alkaloids and flavonoids. Modern pharmacological research has demonstrated its antitumor, hepatoprotective, analgestic, antimicrobial, anti-oxidant, antitussive, and anti-inflammatory activities. However, resource availability, in-depth in vivo pharmacological study and qualitative and quantitative analysis are still insufficient and deserve further efforts. This paper provides a comprehensive advance on the ethnopharmacological, phytochemical, and pharmacological studies of the genus, in hopes of promoting a better understanding of their medicinal values.
[Mh] Termos MeSH primário: Alcaloides/isolamento & purificação
Alcaloides/farmacologia
Flavonoides/isolamento & purificação
Flavonoides/farmacologia
Isoquinolinas/isolamento & purificação
Isoquinolinas/farmacologia
Papaveraceae/química
Fitoterapia
[Mh] Termos MeSH secundário: Alcaloides/uso terapêutico
Analgésicos
Animais
Anti-Infecciosos
Anti-Inflamatórios
Antineoplásicos Fitogênicos
Antioxidantes
Antitussígenos
Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico
Flavonoides/uso terapêutico
Seres Humanos
Isoquinolinas/uso terapêutico
Medicina Tradicional Tibetana
Ratos
Terpenos/isolamento & purificação
Terpenos/farmacologia
Terpenos/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Alkaloids); 0 (Analgesics); 0 (Anti-Infective Agents); 0 (Anti-Inflammatory Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Antitussive Agents); 0 (Flavonoids); 0 (Isoquinolines); 0 (Terpenes)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170113
[Lr] Data última revisão:
170113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160428
[St] Status:MEDLINE
[do] DOI:10.1142/S0192415X16500257


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[PMID]:27039830
[Au] Autor:Li T; He X
[Ad] Endereço:West China School of Pharmacy, Sichuan University.
[Ti] Título:Quantitative Analysis of Salidroside and p-Tyrosol in the Traditional Tibetan Medicine Rhodiola crenulata by Fourier Transform Near-Infrared Spectroscopy.
[So] Source:Chem Pharm Bull (Tokyo);64(4):289-96, 2016.
[Is] ISSN:1347-5223
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:A nondestructive, efficient, and rapid method for quantitative analysis of two bioactive components (salidroside and p-tyrosol) in Rhodiola crenulata, a traditional Tibetan medicine, by Fourier transform near-infrared (FT-NIR) spectroscopy was developed. Near-infrared diffuse reflectance spectra in the range of 4000 to 10000 cm(-1) of 50 samples of Rhodiola crenulata with different sources were measured. To get a satisfying result, partial least squares regression (PLSR) was used to establish NIR models for salidroside and p-tyrosol content determination. Different preprocessing methods, including smoothing, taking a second derivative, standard normal variate (SNV) transformation, and multiplicative scatter correction (MSC), were investigated to improve the model accuracy of PLSR. The performance of the two final models (salidroside model and p-tyrosol model) was evaluated by factors such as the values of correlation coefficient (R(2)), root mean square error of prediction (RMSEP), and root mean square error of calibration (RMSEC). The optimal results of the PLSR model of salidroside showed that R(2), RMSEP and RMSEC were 0.99572, 0.0294 and 0.0309, respectively. Meanwhile, in the optimization model of p-tyrosol, the R(2), RMSEP and RMSEC were 0.99714, 0.0154 and 0.0168, respectively. These results demonstrate that FT-NIR spectroscopy not only provides a precise, rapid method for quantitative analysis of major effective constituents in Rhodiola crenulata, but can also be applied to the quality control of Rhodiola crenulata.
[Mh] Termos MeSH primário: Glucosídeos/análise
Medicina Tradicional Tibetana
Fenóis/análise
Álcool Feniletílico/análogos & derivados
Rhodiola/química
Espectroscopia de Luz Próxima ao Infravermelho/métodos
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Análise de Fourier
Limite de Detecção
Álcool Feniletílico/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Glucosides); 0 (Phenols); 1AK4MU3SNX (4-hydroxyphenylethanol); M983H6N1S9 (rhodioloside); ML9LGA7468 (Phenylethyl Alcohol)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160405
[St] Status:MEDLINE
[do] DOI:10.1248/cpb.c15-00558


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[PMID]:27032305
[Au] Autor:Wu Q; Li WK; Zhou ZP; Li YY; Xiong TW; Du YZ; Wei LX; Liu J
[Ad] Endereço:Key Laboratory for Basic Pharmacology of Ministry of Health, Zunyi Medical College, China.
[Ti] Título:The Tibetan medicine Zuotai differs from HgCl2 and MeHg in producing liver injury in mice.
[So] Source:Regul Toxicol Pharmacol;78:1-7, 2016 Jul.
[Is] ISSN:1096-0295
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: Zuotai is composed mainly of ß-HgS, while cinnabar mainly contains α-HgS. Both forms of HgS are used in traditional medicines and their safety is of concern. This study aimed to compare the hepatotoxicity potential of Zuotai and α-HgS with mercury chloride (HgCl2) and methylmercury (MeHg) in mice. Mice were orally administrated with Zuotai (30 mg/kg), α-HgS (HgS, 30 mg/kg), HgCl2 (33.6 mg/kg), or CH3HgCl (3.1 mg/kg) for 7 days, and liver injury and gene expressions related to toxicity, inflammation and Nrf2 were examined. Animal body weights were decreased by HgCl2 and to a less extent by MeHg. HgCl2 and MeHg produced spotted hepatocyte swelling and inflammation, while such lesions are mild in Zuotai and HgS-treated mice. Liver Hg contents reached 45-70 ng/mg in HgCl2 and MeHg groups; but only 1-2 ng/mg in Zuotai and HgS groups. HgCl2 and MeHg increased the expression of liver injury biomarker genes metallothionein-1 (MT-1) and heme oxygenase-1 (HO-1); the inflammation biomarkers early growth response gene (Egr1), glutathione S-transferase (Gst-mu), chemokine (mKC) and microphage inflammatory protein (MIP-2), while these changes were insignificant in Zuotai and HgS groups. However, all mercury compounds were able to increase the Nrf2 pathway genes NAD(P)H: quinone oxidoreductase 1 (Nqo1) and Glutamate-cysteine ligase, catalytic subunit (Gclc). In conclusion, the Tibetan medicine Zuotai and HgS are less hepatotoxic than HgCl2 and MeHg, and differ from HgCl2 and MeHg in hepatic Hg accumulation and toxicological responses.
[Mh] Termos MeSH primário: Doença Hepática Induzida por Substâncias e Drogas/etiologia
Hepatócitos/efeitos dos fármacos
Fígado/efeitos dos fármacos
Medicina Tradicional Tibetana
Cloreto de Mercúrio/toxicidade
Compostos de Mercúrio/toxicidade
Compostos de Metilmercúrio/toxicidade
[Mh] Termos MeSH secundário: Animais
Biomarcadores/metabolismo
Doença Hepática Induzida por Substâncias e Drogas/genética
Doença Hepática Induzida por Substâncias e Drogas/metabolismo
Doença Hepática Induzida por Substâncias e Drogas/patologia
Regulação da Expressão Gênica/efeitos dos fármacos
Hepatócitos/metabolismo
Hepatócitos/ultraestrutura
Mediadores da Inflamação/metabolismo
Fígado/metabolismo
Fígado/ultraestrutura
Masculino
Cloreto de Mercúrio/metabolismo
Compostos de Mercúrio/metabolismo
Compostos de Metilmercúrio/metabolismo
Camundongos
Fator 2 Relacionado a NF-E2/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Fatores de Tempo
Perda de Peso/efeitos dos fármacos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Inflammation Mediators); 0 (Mercury Compounds); 0 (Methylmercury Compounds); 0 (NF-E2-Related Factor 2); 0 (Nfe2l2 protein, mouse); 0 (zuotai); 53GH7MZT1R (Mercuric Chloride); ZI0T668SF1 (cinnabar)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160402
[St] Status:MEDLINE



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