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[PMID]:28807118
[Au] Autor:Hersant B; SidAhmed-Mezi M; Niddam J; La Padula S; Noel W; Ezzedine K; Rodriguez AM; Meningaud JP
[Ad] Endereço:Department of Maxillofacial and Plastic, Reconstructive, and Aesthetic Surgery, Henri Mondor Hospital, Créteil, France. Electronic address: barbara.hersant@gmail.com.
[Ti] Título:Efficacy of autologous platelet-rich plasma combined with hyaluronic acid on skin facial rejuvenation: A prospective study.
[So] Source:J Am Acad Dermatol;77(3):584-586, 2017 09.
[Is] ISSN:1097-6787
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Adjuvantes Imunológicos/uso terapêutico
Ácido Hialurônico/uso terapêutico
Plasma Rico em Plaquetas
Rejuvenescimento
Fenômenos Fisiológicos da Pele
[Mh] Termos MeSH secundário: Adulto
Transfusão de Sangue Autóloga
Terapia Combinada
Elasticidade
Face
Seres Humanos
Mesoterapia
Meia-Idade
Estudos Prospectivos
[Pt] Tipo de publicação:CLINICAL TRIAL; LETTER
[Nm] Nome de substância:
0 (Adjuvants, Immunologic); 9004-61-9 (Hyaluronic Acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170816
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE


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[PMID]:28121477
[Au] Autor:Berguiga M; Galatoire O
[Ad] Endereço:a Department of Oculoplastic Surgery , Fondation Rothschild , Paris , France.
[Ti] Título:Tear trough rejuvenation: A safety evaluation of the treatment by a semi-cross-linked hyaluronic acid filler.
[So] Source:Orbit;36(1):22-26, 2017 Feb.
[Is] ISSN:1744-5108
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this study is to describe the experience of 33 physicians, dermatologists and surgeons, with the use of a semi-cross-linked hyaluronic acid (HA) gel as a tear trough deformity filler within one month following injection, and to assess patient satisfaction with the procedure. This study is a case series conducted between February 2012 and December 2012 with the use of semi-cross-linked HA to correct tear trough deformity. The filler was administered in the preperiosteal tissues. The study involved case note review and a patient satisfaction survey. A total of 302 eyes of 151 patients were treated by 33 physicians, with a mean follow-up of 3 weeks. Patients were mainly female (86%), and middle-aged (mean age 48 years old). The gel was placed preperiosteally, deep to the orbicularis, anterior to the inferior orbital rim, with a mean volume of 0.48 ml per eye to achieve correction. The injection procedure was performed without local anesthetic for 79% of the patients. No serious adverse event was recorded. Side effects reported by investigators immediately after injection included bruising (11%), swelling (12%), and redness (inflammation 12%). Very few transitional blue discolorations (2.6%) were observed. No patient required dissolution with hyaluronidase. According to our satisfaction survey, all patients had cosmetic improvement. Most patients (97%) described marked or moderate satisfaction with the treatment. At one month, 18% requested additional hyaluronic acid gel for a touch-up injection. This case series confirms the effective use of a semi-cross-linked HA gel in tear trough rejuvenation. It has excellent patient tolerability, minimal complications, and excellent patient satisfaction.
[Mh] Termos MeSH primário: Preenchedores Dérmicos/administração & dosagem
Ácido Hialurônico/administração & dosagem
Aparelho Lacrimal/efeitos dos fármacos
Rejuvenescimento
Envelhecimento da Pele/efeitos dos fármacos
Viscossuplementos/administração & dosagem
[Mh] Termos MeSH secundário: Técnicas Cosméticas
Preenchedores Dérmicos/efeitos adversos
Feminino
Seres Humanos
Ácido Hialurônico/efeitos adversos
Injeções Subcutâneas
Masculino
Mesoterapia
Meia-Idade
Satisfação do Paciente/estatística & dados numéricos
Estudos Prospectivos
Viscossuplementos/efeitos adversos
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Dermal Fillers); 0 (Teosyal 27G Deep Lines); 0 (Viscosupplements); 9004-61-9 (Hyaluronic Acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170126
[St] Status:MEDLINE
[do] DOI:10.1080/01676830.2017.1279641


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[PMID]:27646760
[Au] Autor:Brackeen A
[Ad] Endereço:Lubbock Dermatology and Skin Cancer Center, Lubbock, Texas.
[Ti] Título:A template for estimating doses of deoxycholic acid for submental fat fullness.
[So] Source:J Am Acad Dermatol;75(4):e151-e152, 2016 Oct.
[Is] ISSN:1097-6787
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Ácido Desoxicólico/administração & dosagem
Mesoterapia/instrumentação
Tatuagem/instrumentação
[Mh] Termos MeSH secundário: Adipócitos/efeitos dos fármacos
Queixo
Ácido Desoxicólico/farmacologia
Seres Humanos
Injeções Subcutâneas
Mesoterapia/métodos
Microinjeções
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
005990WHZZ (Deoxycholic Acid)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160921
[St] Status:MEDLINE


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[PMID]:27363773
[Au] Autor:Lee JC; Daniels MA; Roth MZ
[Ad] Endereço:Private Practice, Enhance Medical Center, 462 North Linden Drive, Suite 333, Beverly Hills, CA 90212, USA. Electronic address: Johnsonlee1@gmail.com.
[Ti] Título:Mesotherapy, Microneedling, and Chemical Peels.
[So] Source:Clin Plast Surg;43(3):583-95, 2016 Jul.
[Is] ISSN:1558-0504
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mesotherapy, microneedling, and chemical peels are minimally invasive techniques used to combat facial aging. Chemical peeling is one of the oldest methods of facial rejuvenation. By using different chemicals in various combinations, strengths, and application techniques, plastic surgeons can tailor a patient's treatment for optimal, safe, and consistent results. Mesotherapy and microneedling have emerged in the plastic surgery literature with increasingly complex indications. Both techniques have increased in popularity although research into efficacy and long-term results is lagging. With a thorough understanding of patients and the modalities available, plastic surgeons can use the appropriate minimally invasive technique to provide patients with desired skin changes.
[Mh] Termos MeSH primário: Abrasão Química
Mesoterapia
Rejuvenescimento
Envelhecimento da Pele
[Mh] Termos MeSH secundário: Face
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170107
[Lr] Data última revisão:
170107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160702
[St] Status:MEDLINE


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[PMID]:26614529
[Au] Autor:Buz A; Görgülü T; Olgun A; Kargi E
[Ad] Endereço:Department of Plastic, Reconstructive and Aesthetic Surgery, Bulent Ecevit University Medical Faculty, A blok Kat:3, Kozlu, Zonguldak, Turkey.
[Ti] Título:Efficacy of glutathione mesotherapy in burns: an experimental study.
[So] Source:Eur J Trauma Emerg Surg;42(6):775-783, 2016 Dec.
[Is] ISSN:1863-9941
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Thermal burns are the leading cause of trauma worldwide. Currently, no consensus on optimal treatment of deep partial-thickness (second-degree) burns has emerged, as reflected by the wide variability in available wound-care materials. The relative efficacies of products used for treatment of partial-thickness thermal burns remain unclear. Mesotherapy features intradermal administration of various agents, depending on burn location. In the present experimental study, we explored the efficacy of mesotherapy used to treat partial-thickness thermal burns in 50 male Wistar rats divided into five groups of equal number. No procedure was performed after infliction of thermal burns in control group (Group 1). Mesotherapy was applied with physiological saline in sham group (Group 2), glutathione, taurine, and L-carnitine were separately applied in Group 3, Group 4, and Group 5, respectively. MATERIALS AND METHODS: Mesotherapeutic agents were injected intradermally into the reticular layer of the dermis using the point technique. The first course of mesotherapy was given within the first 2 h after infliction of thermal burns, and therapy was continued to day 10. On day 22, unhealed thermal burn areas were measured prior to sacrifice, and biopsies covering the total areas of burns were performed to allow of pathological evaluation. RESULTS: Group 3 (the glutathione group) showed the best extent of healing, followed by Group 4 (the taurine group) and Group 5 (the L-carnitine group). The healed thermal burn areas in these groups were significantly greater than those in the control and sham groups (P = 0.001). All of healing, acute and chronic inflammation, the amount of granulation tissue, the level of fibroblast maturation, the amount of collagen, the extent of re-epithelization and neovascularization, and ulcer depth were scored upon pathological examination of tissue cross-sections. The best outcomes were evident in the glutathione group, with statistical significance. Although wound healing in the L-carnitine and taurine groups was better than in the control and sham groups, the differences were not statistically significant. CONCLUSION: Thus, glutathione mesotherapy was effective when used to treat partial-thickness thermal burns and may be a useful treatment option for various human burns.
[Mh] Termos MeSH primário: Queimaduras/terapia
Glutationa/farmacologia
Mesoterapia/métodos
[Mh] Termos MeSH secundário: Animais
Biópsia
Carnitina/farmacologia
Injeções Intralesionais
Masculino
Ratos
Ratos Wistar
Taurina/farmacologia
Cicatrização/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
1EQV5MLY3D (Taurine); GAN16C9B8O (Glutathione); S7UI8SM58A (Carnitine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170916
[Lr] Data última revisão:
170916
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151129
[St] Status:MEDLINE


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[PMID]:26179555
[Au] Autor:Kim S; Kye J; Lee M; Park B
[Ad] Endereço:Biomedical Engineering, College of Medicine, Dankook University, Cheonan, Chungnam, Republic of Korea.
[Ti] Título:Evaluation of mesotherapy as a transdermal drug delivery tool.
[So] Source:Skin Res Technol;22(2):158-63, 2016 May.
[Is] ISSN:1600-0846
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: There has been no research about the exact mechanism of transdermal drug delivery during mesotherapy. OBJECTIVE: We aimed to evaluate whether the commercial mesogun can be an appropriate technique for a transdermal drug delivery. MATERIALS AND METHODS: We injected blue ink into the polyurethane foam or pig skin with three types of mesotherapy using a commercial mesogun, or local made intradermal injector, or a manual injection of syringe. To assess the internal pressure of the cylinder and drug delivery time, we designed the evaluation setup using a needle tip pressure transducer. RESULT: All types of injectors induced adequate penetration of blue ink into the polyurethane foam without backflow. In the pig skin, blue ink leaked out rapidly with the backward movement of the needle in the commercial mesogun in contrast to the local made injector or the manual injection of syringe. When the time for backward movement of the syringe approaches 1000 ms, the cylinder pressure of the syringe is saturated at around 25 mmHg which can be translated into the dermal pressure of the pig skin. CONCLUSION: There should be sufficient time between the insertion and withdrawal of the needle of injector for the adequate transdermal drug delivery and it must be considered for mesotherapy.
[Mh] Termos MeSH primário: Administração Cutânea
Injeções Subcutâneas/instrumentação
Tinta
Mesoterapia/instrumentação
Absorção Cutânea/fisiologia
Pele/química
[Mh] Termos MeSH secundário: Animais
Desenho de Equipamento
Análise de Falha de Equipamento
Injeções Subcutâneas/métodos
Mesoterapia/métodos
Pressão
Suínos
[Pt] Tipo de publicação:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170107
[Lr] Data última revisão:
170107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150717
[St] Status:MEDLINE
[do] DOI:10.1111/srt.12243


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[PMID]:25970226
[Au] Autor:Polat M; Üstün H
[Ad] Endereço:a Department of Dermatology , Gazi University School of Medicine , Ankara , Turkey and.
[Ti] Título:A case of mesotherapy-induced panniculitis.
[So] Source:Cutan Ocul Toxicol;35(2):163-4, 2016.
[Is] ISSN:1556-9535
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Mesotherapy was first introduced in Europe for the treatment of localized pain. It is currently used mainly for aesthetical purposes and gradually getting widely used for body contouring, cellulite reduction, and skin rejuvenation. The reports concerning about mesotherapy is increasing in number in the literature. There are reported systemic and local side effects of mesotherapy. Panniculitis is a rare side effect of mesotherapy. In this article, we report a case of mesotherapy-induced panniculitis who responded to dapsone therapy.
[Mh] Termos MeSH primário: Mesoterapia/efeitos adversos
Paniculite/etiologia
[Mh] Termos MeSH secundário: Adulto
Anti-Infecciosos/uso terapêutico
Dapsona/uso terapêutico
Feminino
Seres Humanos
Injeções
Paniculite/tratamento farmacológico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 8W5C518302 (Dapsone)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150514
[St] Status:MEDLINE
[do] DOI:10.3109/15569527.2015.1042110


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[PMID]:25502538
[Au] Autor:Gualdi G; Monari P; Crotti S; Calzavara-Pinton P
[Ad] Endereço:Department of Dermatology, Spedali Civili di Brescia, Brescia, Italy - crotti.silvia@virgilio.it.
[Ti] Título:Acute siliconomas of the face triggered by skin rejuvenation mesotherapy with low weight hyaluronic acid: surgical treatment and pathogenetic hypothesis.
[So] Source:G Ital Dermatol Venereol;151(3):319-21, 2016 Jun.
[Is] ISSN:1827-1820
[Cp] País de publicação:Italy
[La] Idioma:eng
[Mh] Termos MeSH primário: Técnicas Cosméticas/efeitos adversos
Ácido Hialurônico/efeitos adversos
Mesoterapia/efeitos adversos
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Ácido Hialurônico/administração & dosagem
Meia-Idade
Rejuvenescimento
Silicones/efeitos adversos
Envelhecimento da Pele
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Silicones); 9004-61-9 (Hyaluronic Acid)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141216
[St] Status:MEDLINE


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[PMID]:26566569
[Au] Autor:Chen DL; Cohen JL; Green JB
[Ad] Endereço:Department of Dermatology, University of Colorado, Aurora, USA.
[Ti] Título:Injectable agents affecting subcutaneous fats.
[So] Source:Semin Cutan Med Surg;34(3):134-7, 2015 Sep.
[Is] ISSN:1085-5629
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mesotherapy is an intradermal or subcutaneous injection of therapeutic agents to induce local effects, and was pioneered in Europe during the 1950s. For the past 2 decades, there has been significant interest in the use of mesotherapy for minimally invasive local fat contouring. Based on the theorized lipolytic effects of the agent phosphatidylcholine, initial attempts involved its injection into subcutaneous tissue. With further studies, however, it became apparent that the activity attributed to phosphatidylcholine mesotherapy was due to the adipolytic effects of deoxycholate, a detergent used to solubilize phosphatidylcholine. Since then, clinical trials have surfaced that demonstrate the efficacy of a proprietary formulation of deoxycholate for local fat contouring. Current trials on mesotherapy with salmeterol, a b-adrenergic agonist and lipolysis stimulator, are underway-with promising preliminary results as well.
[Mh] Termos MeSH primário: Ácido Desoxicólico/farmacologia
Mesoterapia
Gordura Subcutânea/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adipócitos/efeitos dos fármacos
Seres Humanos
Injeções Subcutâneas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
005990WHZZ (Deoxycholic Acid)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:151114
[Lr] Data última revisão:
151114
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151114
[St] Status:MEDLINE
[do] DOI:10.12788/j.sder.2015.0166


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[PMID]:26083769
[Au] Autor:Saggini R; Di Stefano A; Dodaj I; Scarcello L; Bellomo RG
[Ad] Endereço:1 Department of Medical Science Oral and Biotechnology, G. D'Annunzio University , Chieti, Italy .
[Ti] Título:Pes Anserine Bursitis in Symptomatic Osteoarthritis Patients: A Mesotherapy Treatment Study.
[So] Source:J Altern Complement Med;21(8):480-4, 2015 Aug.
[Is] ISSN:1557-7708
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Pes anserine bursitis strongly affects quality of life in patients with osteoarthritis. Treatment includes nonsteroidal anti-inflammatory drugs (NSAIDs), physiotherapy, and injections of corticosteroid, with highly variable responses; recovery can take 10 days to 36 months. Mesotherapy is a minimally invasive technique consisting of subcutaneous injections of bioactive substances. The goal is to modulate the pharmacokinetics of the injected substance and prolong the effects at a local level. OBJECTIVE: To evaluate the effects of mesotherapy with diclofenac for anserine bursitis associated with knee osteoarthritis. METHODS: One hundred and seventeen patients with anserine bursitis associated with grade II Kellgren-Lawrence knee osteoarthritis, assessed by clinical, radiographic, and ultrasonographic examination, were evaluated and treated. They were randomly divided into two groups (A, mesotherapy; B, control). Group A completed nine sessions of mesotherapy with sodium diclofenac (25 mg/1 mL; Akis®, IBSA, Lugano, Switzerland), 1 mL for each session, three times per week. Group B received 21 oral administrations of sodium diclofenac (50 mg; Voltaren®, Novartis, Parsippany, NJ), once a day for 3 weeks. Primary outcome measures were pain intensity assessed by visual analogue scale (VAS), along with ability to perform activities of daily living, ability to participate in sports, level of pain, symptoms, and quality of life, as assessed by the Knee injury and Osteoarthritis Outcome Score. These measures were performed before and after the treatment period and at 30 and 90 days' follow up. RESULTS: In both groups pain level decreased significantly after the treatment period. Ultrasonography showed a reduction of the hypoechoic area related to anserine bursitis only in group A. CONCLUSION: Administration of conventional NSAIDs (diclofenac) by mesotherapy is effective in managing anserine bursitis in knee osteoarthritis in the short term and mid-term. These observations could be of interest for efforts to reduce the adverse effects of oral administration of anti-inflammatory drugs.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/administração & dosagem
Anti-Inflamatórios não Esteroides/uso terapêutico
Bursite/etiologia
Bursite/terapia
Mesoterapia
Osteoartrite do Joelho/complicações
[Mh] Termos MeSH secundário: Adolescente
Adulto
Análise de Variância
Diclofenaco/administração & dosagem
Diclofenaco/uso terapêutico
Feminino
Seres Humanos
Injeções Subcutâneas
Masculino
Meia-Idade
Medição da Dor
Qualidade de Vida
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 144O8QL0L1 (Diclofenac)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150618
[St] Status:MEDLINE
[do] DOI:10.1089/acm.2015.0007



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