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Pesquisa : E02.190.525.217.771 [Categoria DeCS]
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[PMID]:28910291
[Au] Autor:Bartels DJP; van Laarhoven AIM; Stroo M; Hijne K; Peerdeman KJ; Donders ART; van de Kerkhof PCM; Evers AWM
[Ad] Endereço:Unit Health, Medical and Neuropsychology, Institute of Psychology, Leiden University, Leiden, the Netherlands.
[Ti] Título:Minimizing nocebo effects by conditioning with verbal suggestion: A randomized clinical trial in healthy humans.
[So] Source:PLoS One;12(9):e0182959, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nocebo effects, i.e., adverse treatment effects which are induced by patients' expectations, are known to contribute to the experience of physical symptoms such as pain and itch. A better understanding of how to minimize nocebo responses might eventually contribute to enhanced treatment effects. However, little is known about how to reduce nocebo effects. In the current randomized controlled study, we tested whether nocebo effects can be minimized by positive expectation induction with respect to electrical and histaminic itch stimuli. First, negative expectations about electrical itch stimuli were induced by verbal suggestion and conditioning (part 1: induction of nocebo effect). Second, participants were randomized to either the experimental group or one of the control groups (part 2: reversing nocebo effect). In the experimental group, positive expectations were induced by conditioning with verbal suggestion. In the control groups either the negative expectation induction was continued or an extinction procedure was applied. Afterwards, a histamine application test was conducted. Positive expectation induction resulted in a significantly smaller nocebo effect in comparison with both control groups. Mean change itch NRS scores showed that the nocebo effect was even reversed, indicating a placebo effect. Comparable effects were also found for histamine application. This study is the first to demonstrate that nocebo effects can be minimized and even reversed by conditioning with verbal suggestion. The results of the current study indicate that learning via counterconditioning and verbal suggestion represents a promising strategy for diminishing nocebo responses.
[Mh] Termos MeSH primário: Condicionamento (Psicologia)
Estimulação Elétrica/efeitos adversos
Histamina/efeitos adversos
Prurido/psicologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Voluntários Saudáveis
Seres Humanos
Masculino
Efeito Nocebo
Prurido/etiologia
Fala
Sugestão
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
820484N8I3 (Histamine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182959


  2 / 2726 MEDLINE  
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[PMID]:28846696
[Au] Autor:Cardeña E; Nordhjem B; Marcusson-Clavertz D; Holmqvist K
[Ad] Endereço:Center for Research on Consciousness and Anomalous Psychology (CERCAP), Department of Psychology, Lund University, Lund, Sweden.
[Ti] Título:The "hypnotic state" and eye movements: Less there than meets the eye?
[So] Source:PLoS One;12(8):e0182546, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Responsiveness to hypnotic procedures has been related to unusual eye behaviors for centuries. Kallio and collaborators claimed recently that they had found a reliable index for "the hypnotic state" through eye-tracking methods. Whether or not hypnotic responding involves a special state of consciousness has been part of a contentious debate in the field, so the potential validity of their claim would constitute a landmark. However, their conclusion was based on 1 highly hypnotizable individual compared with 14 controls who were not measured on hypnotizability. We sought to replicate their results with a sample screened for High (n = 16) or Low (n = 13) hypnotizability. We used a factorial 2 (high vs. low hypnotizability) x 2 (hypnosis vs. resting conditions) counterbalanced order design with these eye-tracking tasks: Fixation, Saccade, Optokinetic nystagmus (OKN), Smooth pursuit, and Antisaccade (the first three tasks has been used in Kallio et al.'s experiment). Highs reported being more deeply in hypnosis than Lows but only in the hypnotic condition, as expected. There were no significant main or interaction effects for the Fixation, OKN, or Smooth pursuit tasks. For the Saccade task both Highs and Lows had smaller saccades during hypnosis, and in the Antisaccade task both groups had slower Antisaccades during hypnosis. Although a couple of results suggest that a hypnotic condition may produce reduced eye motility, the lack of significant interactions (e.g., showing only Highs expressing a particular eye behavior during hypnosis) does not support the claim that eye behaviors (at least as measured with the techniques used) are an indicator of a "hypnotic state." Our results do not preclude the possibility that in a more spontaneous or different setting the experience of being hypnotized might relate to specific eye behaviors.
[Mh] Termos MeSH primário: Atenção/fisiologia
Estado de Consciência/fisiologia
Movimentos Oculares/fisiologia
Hipnose/métodos
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Sugestão
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170829
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182546


  3 / 2726 MEDLINE  
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[PMID]:28300521
[Au] Autor:Mohl JC; Schutkofsky MJ
[Ad] Endereço:a Bucks County Community College , Newtown , Pennsylvania, USA.
[Ti] Título:Volitional and Nonvolitional Responses to Hypnotic Suggestions: Predictors and Subjective Experience.
[So] Source:Am J Clin Hypn;59(4):393-413, 2017 Apr.
[Is] ISSN:2160-0562
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This investigation combined the data from two studies that used modified scoring of the Harvard Group Scale of Hypnotic Susceptibility (Shor & Orne, 1962) to evaluate deliberate, volitional responses to suggestions. One study also employed subjective ratings of each item of the Harvard Scale, with comparisons of nonvolitional, volitional, and non-responses. Based on the assumption that participants would have marked volitional responses as positive responses using the traditional scale, the traditional scoring method was found to inflate mean hypnotic responsiveness by nearly one point. Two hypothesized correlates of hypnotic performance, rapport with the hypnotist and a phenomenological measure of hypnosis, increased significantly when volitional responses were taken into account. The way in which participants were recruited did not predict volitional responses, but individuals who reported deliberate responses to suggestions from the Harvard Scale were less likely to express willingness to participate in future studies. Some of the volitional responses to the items were rated as subjectively more real compared to no responses, though nonvolitional responses were rated as the most real compared with compliance responses and no responses for all items. More difficult items were more likely to be performed volitionally than easier items. It is suggested that future studies using hypnotic inventories account for volitional responses. The nature of deliberately produced responses should also be examined using qualitative and quantitative data, especially with respect to how a given suggestion may affect the execution of the volitional behavior.
[Mh] Termos MeSH primário: Sugestão
Volição/fisiologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170404
[Lr] Data última revisão:
170404
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE
[do] DOI:10.1080/00029157.2016.1236328


  4 / 2726 MEDLINE  
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[PMID]:28300519
[Au] Autor:Lifshitz M; Sheiner EO; Olson JA; Thériault R; Raz A
[Ad] Endereço:a McGill University , Montreal , QC , Canada.
[Ti] Título:On Suggestibility and Placebo: A Follow-Up Study.
[So] Source:Am J Clin Hypn;59(4):385-392, 2017 Apr.
[Is] ISSN:2160-0562
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Identifying what makes some people respond well to placebos remains a major challenge. Here, we attempt to replicate an earlier study in which we found a relationship between hypnotic suggestibility and subjective ratings of relaxation following the ingestion of a placebo sedative (Sheiner, Lifshitz, & Raz, 2016). To assess the reliability of this effect, we tested 34 participants using a similar design. Participants ingested a placebo capsule in one of two conditions: (1) relaxation, wherein we described the capsule as a herbal sedative, or (2) control, wherein we described the capsule as inert. To index placebo response, we collected measures of blood pressure and heart rate, as well as self-report ratings of relaxation and drowsiness. Despite using a similar experimental design as in our earlier study, we were unable to replicate the correlation between hypnotic suggestibility and placebo response. Furthermore, whereas in our former experiment we observed a change in subjective ratings of relaxation but no change in physiological measures, here we found that heart rate dropped in the relaxation condition while subjective ratings remained unchanged. Even within a consistent context of relaxation, therefore, our present results indicate that placebos may induce effects that are fickle, tenuous, and unreliable. Although we had low statistical power, our findings tentatively accord with the notion that placebo response likely involves a complex, multifaceted interaction between traits, expectancies, and contexts.
[Mh] Termos MeSH primário: Personalidade/fisiologia
Efeito Placebo
Sugestão
[Mh] Termos MeSH secundário: Adulto
Feminino
Seguimentos
Seres Humanos
Masculino
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170404
[Lr] Data última revisão:
170404
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE
[do] DOI:10.1080/00029157.2016.1225252


  5 / 2726 MEDLINE  
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[PMID]:28285046
[Au] Autor:Liberman Z; Shaw A
[Ad] Endereço:Department of Psychological & Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA 93106, USA. Electronic address: Liberman@psych.ucsb.edu.
[Ti] Título:Children use partial resource sharing as a cue to friendship.
[So] Source:J Exp Child Psychol;159:96-109, 2017 Jul.
[Is] ISSN:1096-0457
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Resource sharing is an important aspect of human society, and how resources are distributed can provide people with crucial information about social structure. Indeed, a recent partiality account of resource distribution suggested that people may use unequal partial resource distributions to make inferences about a distributor's social affiliations. To empirically test this suggestion derived from the theoretical argument of the partiality account, we presented 4- to 9-year-old children with distributors who gave out resources unequally using either a partial procedure (intentionally choosing which recipient would get more) or an impartial procedure (rolling a die to determine which recipient would get more) and asked children to make judgments about whom the distributor was better friends with. At each age tested, children expected a distributor who gave partially to be better friends with the favored recipient (Studies 1-3). Interestingly, younger children (4- to 6-year-olds) inferred friendship between the distributor and the favored recipient even in cases where the distributor used an impartial procedure, whereas older children (7- to 9-year-olds) did not infer friendship based on impartial distributions (Study 1). These studies demonstrate that children use third-party resource distributions to make important predictions about the social world and add to our knowledge about the developmental trajectory of understanding the importance of partiality in addition to inequity when making social inferences.
[Mh] Termos MeSH primário: Altruísmo
Sinais (Psicologia)
Amigos/psicologia
Fatores Socioeconômicos
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Feminino
Seres Humanos
Intenção
Julgamento
Comportamento Social
Sugestão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170526
[Lr] Data última revisão:
170526
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170313
[St] Status:MEDLINE


  6 / 2726 MEDLINE  
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[PMID]:28264983
[Au] Autor:Koban L; Kross E; Woo CW; Ruzic L; Wager TD
[Ad] Endereço:Institute of Cognitive Science and leonie.koban@colorado.edu.
[Ti] Título:Frontal-Brainstem Pathways Mediating Placebo Effects on Social Rejection.
[So] Source:J Neurosci;37(13):3621-3631, 2017 Mar 29.
[Is] ISSN:1529-2401
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Placebo treatments can strongly affect clinical outcomes, but research on how they shape other life experiences and emotional well-being is in its infancy. We used fMRI in humans to examine placebo effects on a particularly impactful life experience, social pain elicited by a recent romantic rejection. We compared these effects with placebo effects on physical (heat) pain, which are thought to depend on pathways connecting prefrontal cortex and periaqueductal gray (PAG). Placebo treatment, compared with control, reduced both social and physical pain, and increased activity in the dorsolateral prefrontal cortex (dlPFC) in both modalities. Placebo further altered the relationship between affect and both dlPFC and PAG activity during social pain, and effects on behavior were mediated by a pathway connecting dlPFC to the PAG, building on recent work implicating opioidergic PAG activity in the regulation of social pain. These findings suggest that placebo treatments reduce emotional distress by altering affective representations in frontal-brainstem systems. Placebo effects are improvements due to expectations and the socio-medical context in which treatment takes place. Whereas they have been extensively studied in the context of somatic conditions such as pain, much less is known of how treatment expectations shape the emotional experience of other important stressors and life events. Here, we use brain imaging to show that placebo treatment reduces the painful feelings associated with a recent romantic rejection by recruiting a prefrontal-brainstem network and by shifting the relationship between brain activity and affect. Our findings suggest that this brain network may be important for nonspecific treatment effects across a wide range of therapeutic approaches and mental health conditions.
[Mh] Termos MeSH primário: Analgesia/psicologia
Tronco Encefálico/fisiologia
Lobo Frontal/fisiologia
Percepção da Dor/fisiologia
Distância Social
Sugestão
[Mh] Termos MeSH secundário: Adolescente
Adulto
Afeto
Tronco Encefálico/efeitos dos fármacos
Feminino
Lobo Frontal/efeitos dos fármacos
Seres Humanos
Masculino
Rede Nervosa/diagnóstico por imagem
Rede Nervosa/fisiologia
Vias Neurais/efeitos dos fármacos
Vias Neurais/fisiologia
Percepção da Dor/efeitos dos fármacos
Efeito Placebo
Placebos/administração & dosagem
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Placebos)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170930
[Lr] Data última revisão:
170930
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170308
[St] Status:MEDLINE
[do] DOI:10.1523/JNEUROSCI.2658-16.2017


  7 / 2726 MEDLINE  
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[PMID]:28189976
[Au] Autor:Conson M; Salzano S; Frolli A; Mazzarella E
[Ad] Endereço:Department of Psychology, Second University of Naples, Caserta, Italy. Electronic address: massimiliano.conson@unina2.it.
[Ti] Título:The peer's point of view: Observing a peer performing an action enhances third-person perspective in adolescents.
[So] Source:J Adolesc;56:84-90, 2017 Apr.
[Is] ISSN:1095-9254
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Adolescents are particularly prone to peer influence. Since group membership modulates the person's tendency to take someone else's viewpoint, here we decided to investigate whether adolescents are influenced by the presence of a peer when taking another person's perspective. A group of adolescents from upper secondary schools in Naples (Italy) had to observe scenes of an actor (an adolescent or an adult) gazing, grasping, gazing/grasping an object or staying still. When required to judge the spatial location of the object, the adolescent participants adopted the actor's viewpoint (third-person perspective) more frequently when the actor was an adolescent rather than when he was an adult and when the adolescent actor grasped the object. Thus, adolescents seem particularly prone to mentally simulate someone else's actions when the other person is a peer. These findings suggest that modulating motor simulation processes via social environmental factors could influence adolescents' perspective taking.
[Mh] Termos MeSH primário: Comportamento do Adolescente/psicologia
Observação
Grupo Associado
[Mh] Termos MeSH secundário: Adolescente
Adulto
Fatores Etários
Feminino
Seres Humanos
Masculino
Sugestão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170213
[St] Status:MEDLINE


  8 / 2726 MEDLINE  
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[PMID]:28077327
[Au] Autor:Zahedi A; Stuermer B; Hatami J; Rostami R; Sommer W
[Ad] Endereço:University of Tehran, Iran.
[Ti] Título:Eliminating stroop effects with post-hypnotic instructions: Brain mechanisms inferred from EEG.
[So] Source:Neuropsychologia;96:70-77, 2017 Feb.
[Is] ISSN:1873-3514
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The classic Stroop task demonstrates the persistent and automatic effects of the meaning of color words that are very hard to inhibit when the task is to name the word color. Post-hypnotic instructions may enable highly-hypnotizable participants to inhibit the automatic access to word meaning. Here we compared the consequences of hypnosis alone and hypnosis with post-hypnotic instructions on the Stroop effect and its facilitation and inhibition components. Importantly, we studied the mechanisms of the hypnosis effects at the neural level by analyzing EEG frequencies. Highly hypnotizable participants performed the Stroop task in a counterbalanced design following (1) post-hypnotic suggestions that words had lost their meaning, (2) after hypnosis alone, and (3) in a control condition without hypnosis. The overall Stroop effect and both its facilitation and interference components, were not significant after the post-hypnotic suggestion but in both other conditions. Hypnosis alone neither affected the Stroop effect nor - in contrast to some previous reports and claims - overall performance. EEG recorded during the Stroop task showed a significant increase in both frontal theta and frontal beta power when participants were under the impact of post-hypnotic suggestions, in comparison to the two other sessions. Together, these findings indicate that post-hypnotic suggestions - but not hypnosis alone - are powerful tools for eliciting top down processes. Our EEG findings could be interpreted as clue that this is due to the investment of additional cognitive control.
[Mh] Termos MeSH primário: Atenção/fisiologia
Encéfalo/fisiologia
Hipnose/métodos
Teste de Stroop
Sugestão
Ritmo Teta/fisiologia
[Mh] Termos MeSH secundário: Adulto
Eletroencefalografia
Função Executiva/fisiologia
Feminino
Seres Humanos
Inibição (Psicologia)
Masculino
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170113
[St] Status:MEDLINE


  9 / 2726 MEDLINE  
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[PMID]:27490850
[Au] Autor:Derbyshire SW; Whalley MG; Seah ST; Oakley DA
[Ad] Endereço:From the National University of Singapore Department of Psychology and NUS-A*STAR Clinical Imaging Research Centre (Derbyshire, Shea), Berkshire Clinical Health Psychology Service and Berkshire Traumatic Stress Service (Whalley) and University College London, Department of Psychology and Language Sciences (Oakley).
[Ti] Título:Suggestions to Reduce Clinical Fibromyalgia Pain and Experimentally Induced Pain Produce Parallel Effects on Perceived Pain but Divergent Functional MRI-Based Brain Activity.
[So] Source:Psychosom Med;79(2):189-200, 2017 Feb/Mar.
[Is] ISSN:1534-7796
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Hypnotic suggestion is an empirically validated form of pain control; however, the underlying mechanism remains unclear. METHODS: Thirteen fibromyalgia patients received suggestions to alter their clinical pain, and 15 healthy controls received suggestions to alter experimental heat pain. Suggestions were delivered before and after hypnotic induction with blood oxygen level-dependent (BOLD) activity measured concurrently. RESULTS: Across groups, suggestion produced substantial changes in pain report (main effect of suggestion, F2, 312 = 585.8; p < .0001), with marginally larger changes after induction (main effect of induction, F1, 312 = 3.6; p = .060). In patients, BOLD response increased with pain report in regions previously associated with pain, including thalamus and anterior cingulate cortex. In controls, BOLD response decreased with pain report. All changes were greater after induction. Region-of-interest analysis revealed largely linear patient responses with increasing pain report. Control responses, however, were higher after suggestion to increase or decrease pain from baseline. CONCLUSIONS: Based on behavioral report alone, the mechanism of suggestion could be interpreted as largely similar regardless of the induction or type of pain experience. The functional magnetic resonance imaging data, however, demonstrated larger changes in brain activity after induction and a radically different pattern of brain activity for clinical pain compared with experimental pain. These findings imply that induction has an important effect on underlying neural activity mediating the effects of suggestion, and the mechanism of suggestion in patients altering clinical pain differs from that in controls altering experimental pain. Patient responses imply that suggestions altered pain experience via corresponding changes in pain-related brain regions, whereas control responses imply suggestion engaged cognitive control.
[Mh] Termos MeSH primário: Fibromialgia/fisiopatologia
Giro do Cíngulo/fisiopatologia
Manejo da Dor/métodos
Percepção da Dor/fisiologia
Dor/fisiopatologia
Sugestão
Tálamo/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Fibromialgia/psicologia
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Dor/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160805
[St] Status:MEDLINE
[do] DOI:10.1097/PSY.0000000000000370


  10 / 2726 MEDLINE  
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[PMID]:27402432
[Au] Autor:Gudjonsson G
[Ad] Endereço:King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Reykjavik University, Iceland. Electronic address: gisli.gudjonsson@kcl.ac.uk.
[Ti] Título:Memory distrust syndrome, confabulation and false confession.
[So] Source:Cortex;87:156-165, 2017 Feb.
[Is] ISSN:1973-8102
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:There are three types of false confessions: 'voluntary', 'pressured-compliant' and 'pressured-internalized'. On the basis of case studies, in the early 1980s Gudjonsson and MacKeith coined the term 'memory distrust syndrome (MDS)' to describe a condition where people develop profound distrust of their memory and become susceptible to relying on external cues and suggestions from others. Memory distrust can, under certain circumstances, lead to a false confession, particularly of the pressured-internalized type, described as 'confabulation'. This article reviews the evidence for the condition and the psychological mechanism and processes involved. A heuristic model is then presented of a 32 year old man who falsely confessed to murder whilst in police custody. The key elements of the model involve the impact of 'contextual risk factors' (i.e., isolation, long and persistent guilt presumptive interrogation, and high emotional intensity) on 'enduring' vulnerability and 'acute state' factors. The detainee had kept a detailed diary whilst in solitary confinement that provided a unique insight into the gradual development of a MDS, his mental state, and thinking process. This type of false confession is apparently quite rare, but it can occur in intellectually able and educated individuals and involves 'delayed' rather than 'immediate' suggestibility.
[Mh] Termos MeSH primário: Transtornos da Memória/psicologia
Repressão Psicológica
Sugestão
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160713
[St] Status:MEDLINE



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