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Pesquisa : E02.319 [Categoria DeCS]
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[PMID]:29441974
[Au] Autor:Gudienè V
[Ti] Título:The medical treatment of Maria, Dowager Empress of the Russian Empire: an analysis of her prescription book from 1807 and 1808.
[So] Source:Pharmazie;71(11):670-679, 2016 Nov 02.
[Is] ISSN:0031-7144
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:This study analyzes the medicines that were used to treat the Dowager Russian Empress Maria, widow of Tsar Paul I, and describes the doctors who cared for her health in 1807 and 1808. The source for this research was the imperial court pharmacy prescription book 1807-1811. Hypotheses about the diseases and medical problems of the Empress and how treatment for her differed according to circumstances, particularly after the loss of her granddaughter Princess Elizabeth, have been made based on the prescriptions recorded in the book. The content of the prescriptions suggests that the Empress suffered from gastrointestinal tract disorders, skin and eye diseases, neuralgic pains and insomnia. Foreign physicians educated in European universities worked at the imperial court and implemented European medical traditions. They took high positions in the administration and the medical education system, and gradually spread their experience and modern knowledge to Tsarist Russian society.
[Mh] Termos MeSH primário: Prescrições de Medicamentos/história
Tratamento Farmacológico/história
[Mh] Termos MeSH secundário: Livros
Quimioterapia Combinada
História do Século XIX
Farmácias
Médicos
Federação Russa
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1691/ph.2016.6067


  2 / 16653 MEDLINE  
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[PMID]:29258977
[Au] Autor:Low CA; Dey AK; Ferreira D; Kamarck T; Sun W; Bae S; Doryab A
[Ad] Endereço:Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.
[Ti] Título:Estimation of Symptom Severity During Chemotherapy From Passively Sensed Data: Exploratory Study.
[So] Source:J Med Internet Res;19(12):e420, 2017 Dec 19.
[Is] ISSN:1438-8871
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Physical and psychological symptoms are common during chemotherapy in cancer patients, and real-time monitoring of these symptoms can improve patient outcomes. Sensors embedded in mobile phones and wearable activity trackers could be potentially useful in monitoring symptoms passively, with minimal patient burden. OBJECTIVE: The aim of this study was to explore whether passively sensed mobile phone and Fitbit data could be used to estimate daily symptom burden during chemotherapy. METHODS: A total of 14 patients undergoing chemotherapy for gastrointestinal cancer participated in the 4-week study. Participants carried an Android phone and wore a Fitbit device for the duration of the study and also completed daily severity ratings of 12 common symptoms. Symptom severity ratings were summed to create a total symptom burden score for each day, and ratings were centered on individual patient means and categorized into low, average, and high symptom burden days. Day-level features were extracted from raw mobile phone sensor and Fitbit data and included features reflecting mobility and activity, sleep, phone usage (eg, duration of interaction with phone and apps), and communication (eg, number of incoming and outgoing calls and messages). We used a rotation random forests classifier with cross-validation and resampling with replacement to evaluate population and individual model performance and correlation-based feature subset selection to select nonredundant features with the best predictive ability. RESULTS: Across 295 days of data with both symptom and sensor data, a number of mobile phone and Fitbit features were correlated with patient-reported symptom burden scores. We achieved an accuracy of 88.1% for our population model. The subset of features with the best accuracy included sedentary behavior as the most frequent activity, fewer minutes in light physical activity, less variable and average acceleration of the phone, and longer screen-on time and interactions with apps on the phone. Mobile phone features had better predictive ability than Fitbit features. Accuracy of individual models ranged from 78.1% to 100% (mean 88.4%), and subsets of relevant features varied across participants. CONCLUSIONS: Passive sensor data, including mobile phone accelerometer and usage and Fitbit-assessed activity and sleep, were related to daily symptom burden during chemotherapy. These findings highlight opportunities for long-term monitoring of cancer patients during chemotherapy with minimal patient burden as well as real-time adaptive interventions aimed at early management of worsening or severe symptoms.
[Mh] Termos MeSH primário: Tratamento Farmacológico/métodos
Neoplasias/tratamento farmacológico
Neoplasias/terapia
Medidas de Resultados Relatados pelo Paciente
Telemedicina/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.2196/jmir.9046


  3 / 16653 MEDLINE  
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[PMID]:27776289
[Au] Autor:Medeiros BC; Gale RP
[Ad] Endereço:Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: brunom@stanford.edu.
[Ti] Título:Why do subjects on clinical trials discontinue therapy? Do we really know?
[So] Source:Leuk Res;51:19-21, 2016 12.
[Is] ISSN:1873-5835
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Ensaios Clínicos como Assunto/estatística & dados numéricos
Tratamento Farmacológico/estatística & dados numéricos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/etiologia
Sujeitos da Pesquisa/estatística & dados numéricos
Recusa do Paciente ao Tratamento/estatística & dados numéricos
[Mh] Termos MeSH secundário: Ensaios Clínicos como Assunto/métodos
Tratamento Farmacológico/métodos
Seres Humanos
Avaliação de Resultados (Cuidados de Saúde)/métodos
Avaliação de Resultados (Cuidados de Saúde)/estatística & dados numéricos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:29369280
[Au] Autor:Smith DMR; Kautz DD
[Ad] Endereço:Debbie Montgomery R. Smith is an emergency nurse at W. G. (Bill) Hefner VA Medical Center in Salisbury, N.C., and float pool nurse at Wake Forest Baptist Health-Lexington Medical Center in Lexington, N.C. Donald Kautz is retired, Associate Professor Emeritus, in the School of Nursing at the University of North Carolina Greensboro.
[Ti] Título:Protect older adults from polypharmacy hazards.
[So] Source:Nursing;48(2):56-59, 2018 Feb.
[Is] ISSN:1538-8689
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Tratamento Farmacológico/enfermagem
Enfermagem Geriátrica
Polimedicação
[Mh] Termos MeSH secundário: Idoso
Comorbidade
Seres Humanos
Adesão à Medicação
Relações Enfermeiro-Paciente
Avaliação em Enfermagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.1097/01.NURSE.0000527602.17216.6d


  5 / 16653 MEDLINE  
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[PMID]:29300785
[Au] Autor:Ayele AA; Mekuria AB; Tegegn HG; Gebresillassie BM; Mekonnen AB; Erku DA
[Ad] Endereço:Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
[Ti] Título:Management of minor ailments in a community pharmacy setting: Findings from simulated visits and qualitative study in Gondar town, Ethiopia.
[So] Source:PLoS One;13(1):e0190583, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Community pharmacy professionals are being widely accepted as sources of treatment and advice for managing minor ailments, largely owing to their location at the heart of the community. The aim of the present study was, therefore, to document the involvement of community pharmacy professionals in the management of minor ailments and perceived barriers that limit their provision of such services. Simulated patient (SP) visits combined with a qualitative study using in-depth interviews was conducted among community pharmacy professionals in Gondar town, Northwest Ethiopia. Scenarios of three different minor ailments (uncomplicated upper respiratory tract infection, back pain and acute diarrhea) were selected and results were reported as percentages. Pharmacy professionals were also interviewed about the barriers in the management of minor ailments. Out of 66 simulated visits, 61 cases (92.4%) provided one or more medications to the SPs. Pharmacy professionals in 16 visits asked SPs information on details of symptoms and past medical and medication history. Ibuprofen alone or in combination with paracetamol was the most commonly dispensed analgesics for back pain. Oral rehydration fluid (ORS) with zinc was the most frequently dispensed medication (33.3%) for the management of acute diarrhea followed by mebendazole (23.9%). Moreover, amoxicillin-clavulanic acid capsule (35%) followed by Amoxicillin (25%) were the most commonly dispensed antibiotics for uncomplicated upper respiratory tract infection. Lack of clinical training and poor community awareness towards the role of community pharmacists in the management of minor ailments were the main barriers for the provision of minor ailment management by community pharmacy professionals. Overall, community pharmacists provided inadequate therapy for the simulated minor ailments. Lack of access to clinical training and poor community awareness were the most commonly cited barriers for providing such services. So as to improve community pharmacists' involvement in managing minor ailments and optimize the contribution of pharmacists, interventions should focus on overcoming the identified barriers.
[Mh] Termos MeSH primário: Serviços Comunitários de Farmácia/organização & administração
[Mh] Termos MeSH secundário: Doença/classificação
Tratamento Farmacológico
Etiópia
Pesquisa Qualitativa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180105
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190583


  6 / 16653 MEDLINE  
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[PMID]:29233285
[Au] Autor:Mead T; Pilla D
[Ad] Endereço:Research Family Medicine Residency Program, 450, Kansas City, MO 64131, USA; University of Missouri-Kansas City School of Pharmacy, St., Kansas City, MO 64108, USA. Electronic address: meadt@umkc.edu.
[Ti] Título:Assessment of clinical and educational interventions that Advanced Pharmacy Practice Experience (APPE) students contributed to a family medicine residency program.
[So] Source:Curr Pharm Teach Learn;9(3):460-467, 2017 May.
[Is] ISSN:1877-1300
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: The literature firmly establishes that clinical interventions made by pharmacy students on Advanced Pharmacy Practice Experience (APPE) rotations contribute significantly to cost-savings realized by the hosting practice sites. The Accreditation Council for Pharmacy Education (ACPE) specifies the experiential curricula include opportunities for students to learn about, from, and with other members of the healthcare team through interprofessional education activities. EDUCATIONAL ACTIVITY: This study assesses clinical and educational interventions contributed by APPE students at a family medicine residency program to determine the extent students were engaged in the interprofessional team and physicians' receptiveness to the recommendations. FINDINGS: Student interventions made from January 2009 to September 2012 were recorded in a Microsoft Excel Spreadsheet. Data was evaluated to determine 1) the most common types of clinical and educational interventions, 2) potential associated cost-savings/avoidance, and 3) provider receptiveness to recommendations based upon acceptance rates. A standardized scheme was utilized to assign a cost savings value according to Midwest America Division of Hospital Corporation of America (HCA) clinical savings standards. Pharmacy students contributed 2868 interventions in 3.5 years. A total of 59.2% of interventions were clinical and accounted for an estimated cost savings of $55,892. The remaining 40.8% of interventions were pharmacy care activities, none were associated with a cost savings and three-fourths were considered educational. Intervention acceptance rate was over 80%, showing providers were very receptive to pharmacy students. SUMMARY: This study lends support that APPE students provide substantial clinical and educational contributions to healthcare providers and patients affiliated with family medicine residency programs. Additionally, healthcare providers and patients are very receptive to pharmacy students as members of the interprofessional team.
[Mh] Termos MeSH primário: Atitude do Pessoal de Saúde
Estágio Clínico
Redução de Custos
Medicina de Família e Comunidade/educação
Custos de Cuidados de Saúde
Estudantes de Farmácia
[Mh] Termos MeSH secundário: Tratamento Farmacológico/economia
Educação em Farmácia
Seres Humanos
Comunicação Interdisciplinar
Internato e Residência
Equipe de Assistência ao Paciente
Preparações Farmacêuticas/administração & dosagem
Preparações Farmacêuticas/economia
Administração Farmacêutica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pharmaceutical Preparations)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE


  7 / 16653 MEDLINE  
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[PMID]:27776546
[Au] Autor:Fisher D; Wicks P; Babar ZU
[Ad] Endereço:Infectious Disease Division, Department of Medicine, National University Hospital; National University Health Systems, 1E Kent Ridge Rd, Singapore, 119228, Singapore. mdcfda@nus.edu.sg.
[Ti] Título:Medicine and the future of health: reflecting on the past to forge ahead.
[So] Source:BMC Med;14(1):169, 2016 10 25.
[Is] ISSN:1741-7015
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The development of new therapies has a rich history, evolves quickly with societal trends, and will have an exciting future. The last century has seen an exponential increase in complex interactions between medical practitioners, pharmaceutical companies, governments and patients. We believe technology and societal expectations will open up the opportunity for more individuals to participate as information becomes more freely available and inequality less acceptable. Corporations must recognize that usual market forces do not function ideally in a setting where health is regarded as a human right, and as modern consumers, patients will increasingly take control of their own data, wellbeing, and even the means of production for developing their own treatments. Ethics and legislation will increasingly impact the processes that facilitate drug development, distribution and administration. This article collection is a cross-journal collaboration, between the Journal of Pharmaceutical Policy and Practice (JoPPP) and BMC Medicine that seeks to cover recent advances in drug development, medicines use, policy and access with high clinical and public health relevance in the future.The Medicine and the Future of Health article collection is a joint collection between BMC Medicine and Journal of Pharmaceutical Policy and Practice. Therefore, this Editorial by the guest editors has been published in both journals.
[Mh] Termos MeSH primário: Tratamento Farmacológico/tendências
Farmacologia/tendências
[Mh] Termos MeSH secundário: Indústria Farmacêutica/tendências
Saúde Global
Política de Saúde/tendências
Acesso aos Serviços de Saúde
Seres Humanos
Publicações/tendências
[Pt] Tipo de publicação:EDITORIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180127
[Lr] Data última revisão:
180127
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


  8 / 16653 MEDLINE  
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[PMID]:29243475
[Au] Autor:Keränen T; Pasternack A; Halkoaho A
[Ti] Título:Hope for better treatment in participating clinical drug trials.
[So] Source:Duodecim;133(6):587-91, 2017.
[Is] ISSN:0012-7183
[Cp] País de publicação:Finland
[La] Idioma:eng
[Ab] Resumo:An informed consent is a prerequisite for participating in medical trials, whereby the person asked to take part in the trial shall understand what he is committing himself to, and that the consent is given voluntarily. Voluntariness can be undermined by so-called therapeutic optimism, i.e. belief in personal benefit brought about by the trial, as well as the difficulty of understanding how conventional treatment and the trial differ from each other, i.e. the so-called therapeutic misconception. The investigator, especially if he is also the attending physician, may influence the development of therapeutic misconception, because the participant may assume that the physician works as an investigator for the best benefit of the patients. It is important to recognize unrealistic optimism and therapeutic misconception of the trial, because for the participant they may result in disappointment and loss of confidence during the trial.
[Mh] Termos MeSH primário: Ensaios Clínicos como Assunto/ética
Tratamento Farmacológico
Ética em Pesquisa
Consentimento Livre e Esclarecido
Mal-Entendido Terapêutico
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180115
[Lr] Data última revisão:
180115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE


  9 / 16653 MEDLINE  
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[PMID]:29199252
[Au] Autor:Imai T
[Ad] Endereço:Department of Pharmacy, Nihon University Itabashi Hospital.
[Ti] Título:[Evaluation of Pharmacotherapy on Emergency and Intensive Care Medicine: The Influence of Intensity and Duration of Invasion].
[So] Source:Yakugaku Zasshi;137(12):1427-1430, 2017.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Critically ill patients who receive high-level invasion show physiological changes different from those under more normal conditions, along with variable therapeutic effects and pharmacokinetics. The concept of systemic inflammatory response syndrome (SIRS) has been introduced to describe the clinical state resulting from invasive actions taken under acute circumstances, resulting in an acute-phase systemic response. In particular, dosages of vancomycin (VCM) and phenytoin (PHT) need to be adjusted by therapeutic drug monitoring (TDM) because of their narrow therapeutic concentration windows. However, there are few reports on the pharmacokinetics of VCM and PHT in patients with SIRS. We performed a retrospective cohort study of patients treated with VCM and PHT. These studies suggest that the pharmacokinetics of VCM are affected by SIRS score and duration. Furthermore, the concentration of PHT was also shown to be higher in SIRS patients compared with non-SIRS patients. These findings suggest that the pharmacokinetics of VCM and PHT may be affected by the pathology of SIRS, rather than by other patient characteristics. Modifying dosing according to SIRS will improve the prediction accuracy of drug concentration based on TDM. In this review, I introduce work conducted by pharmacists in the clinical study of critically ill patients, and will be discussing the evaluation of pharmacotherapy in emergency and intensive care medicine.
[Mh] Termos MeSH primário: Cuidados Críticos
Estado Terminal/terapia
Tratamento Farmacológico
Serviços Médicos de Emergência
[Mh] Termos MeSH secundário: Monitoramento de Medicamentos
Seres Humanos
Fenitoína/administração & dosagem
Fenitoína/farmacocinética
Síndrome de Resposta Inflamatória Sistêmica/tratamento farmacológico
Vancomicina/administração & dosagem
Vancomicina/farmacocinética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
6158TKW0C5 (Phenytoin); 6Q205EH1VU (Vancomycin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.17-00139-1


  10 / 16653 MEDLINE  
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[PMID]:29220129
[Au] Autor:Selde W
[Ti] Título:Damage Control: Resuscitation.
[So] Source:JEMS;42(4):34-9, 2017 04.
[Is] ISSN:0197-2510
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Serviços Médicos de Emergência
Tratamento de Emergência
Medicina Militar
Ressuscitação/métodos
Ferimentos e Lesões/terapia
[Mh] Termos MeSH secundário: Transfusão de Componentes Sanguíneos
Tratamento Farmacológico
Hidratação
Hemorragia/prevenção & controle
Seres Humanos
Hipotermia/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:H
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE



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