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[PMID]:28877115
[Au] Autor:Wickett RR; Damjanovic B
[Ad] Endereço:R. Randall Wickett, PhD, James L. Winkle College of Pharmacy, Cincinnati, Ohio. Bronson Damjanovic, BS, Coloplast Corporation, Mankato, Minnesota.
[Ti] Título:Quantitation of 24-Hour Moisturization by Electrical Measurements of Skin Hydration.
[So] Source:J Wound Ostomy Continence Nurs;44(5):487-491, 2017 Sep/Oct.
[Is] ISSN:1528-3976
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The purpose of this study was to quantify the effects of several moisturizers on hydration of the stratum corneum by measuring their effect on electrical conductance over a 24-hour period. DESIGN: Double-blind, randomized controlled trial. SUBJECTS AND SETTING: Twenty-five healthy female volunteers aged 18 to 65 years with dry skin on the lower legs and no other known dermatologic pathology participated in the study. Additional exclusion criteria were pregnant or taking anti-inflammatory steroids. The study was carried out in a clinical research facility in Winnipeg, Manitoba, Canada. METHODS: Subjects underwent a 3-day conditioning period using a natural soap bar on the lower legs and no application of moisturizer to the skin. Participants then came to the test site and equilibrated for at least 30 minutes under controlled conditions of temperature and humidity. After baseline hydration measurements on test sites on the lower legs of each subject, a single application of each of 5 test products at a dose of 2 mg/cm was made. Skin hydration was assessed by electrical conductance measurements with a specialized probe. The probe was briefly placed on the skin surface with light pressure, and the measurement recorded in units of microsiemens (µS). Conductance was measured at 2, 4, 6, 8, and 24 hours after product applications. RESULTS: Although all but 1 of the test products increased conductance at 2 hours, only 2 moisturizers containing high levels of glycerin (products C and E) maintained increased conductance relative to baseline at 24 hours, +37.8 (P < .001) and +103.5 (P < .001), respectively. CONCLUSIONS: Moisturizers containing high levels of glycerin can provide a measurable moisturization benefit as determined by skin conductance for at least 24 hours after a single application.
[Mh] Termos MeSH primário: Condutividade Elétrica/classificação
Hipodermóclise/classificação
Creme para a Pele/normas
[Mh] Termos MeSH secundário: Adulto
Canadá
Método Duplo-Cego
Feminino
Glicerol/farmacologia
Glicerol/uso terapêutico
Seres Humanos
Creme para a Pele/farmacologia
Creme para a Pele/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
PDC6A3C0OX (Glycerol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE
[do] DOI:10.1097/WON.0000000000000363


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[PMID]:28601540
[Au] Autor:Rojas-Perez-Ezquerra P; Noguerado-Mellado B; Morales-Cabeza C; Zambrano Ibarra G; Datino Romaniega T
[Ad] Endereço:Allergy Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain. Electronic address: patricia.rojas@salud.madrid.org.
[Ti] Título:Atrial Fibrillation in Anaphylaxis.
[So] Source:Am J Med;130(9):1114-1116, 2017 Sep.
[Is] ISSN:1555-7162
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The relationship between anaphylaxis and cardiovascular events has been reported in the past. While skin and respiratory symptoms are usually the most common and the first to appear, cardiovascular complications play a key role and represent the leading cause of death in anaphylaxis. METHODS: We report 3 episodes of atrial fibrillation triggered by anaphylaxis. Allergy and cardiology studies were performed. In both patients, the etiological agent was identified: Anisakis simplex hypersensitivity and food allergy. RESULTS: The heart is the source and target of chemical mediators released during an allergic reaction. In the heart, there are plenty of mast cells, and they are predominantly located around the coronary adventitia and in close contact with small vessels in the muscle wall. The release of mediators can influence ventricular function, heart rate, and coronary artery tone. Anaphylaxis can trigger any kind of arrhythmia. In these cases, the very interesting point of discussion was: which should be first, treating anaphylaxis or cardiac events? The other controversial point was the use of epinephrine, the first line of treatment for anaphylaxis. Recommendations about epinephrine in cardiac patients during an anaphylactic event are still a major dilemma. CONCLUSIONS: We emphasize the importance of the priority of establishing protocols between cardiologist and allergist in treatment of cardiac complications during anaphylaxis, and we warn about the correct diagnosis of arrhythmias in anaphylaxis in order to treat them as soon as possible, to prevent other consequences and complications.
[Mh] Termos MeSH primário: Anafilaxia/complicações
Atenolol/administração & dosagem
Fibrilação Atrial/etiologia
Clorfeniramina/administração & dosagem
Epinefrina/uso terapêutico
Hipersensibilidade Alimentar/complicações
Metilprednisolona/uso terapêutico
Urticária/complicações
[Mh] Termos MeSH secundário: Actinidia/efeitos adversos
Actinidia/imunologia
Administração Intravenosa
Adulto
Idoso de 80 Anos ou mais
Anafilaxia/tratamento farmacológico
Anafilaxia/etiologia
Animais
Anisakis/imunologia
Anisakis/parasitologia
Antiarrítmicos/administração & dosagem
Antiarrítmicos/imunologia
Antiarrítmicos/uso terapêutico
Anti-Inflamatórios/administração & dosagem
Anti-Inflamatórios/uso terapêutico
Arachis/efeitos adversos
Arachis/imunologia
Atenolol/imunologia
Atenolol/uso terapêutico
Fibrilação Atrial/tratamento farmacológico
Broncodilatadores/administração & dosagem
Broncodilatadores/uso terapêutico
Clorfeniramina/uso terapêutico
Quimioterapia Combinada
Epinefrina/administração & dosagem
Hipersensibilidade Alimentar/diagnóstico
Hipersensibilidade Alimentar/tratamento farmacológico
Hipersensibilidade Alimentar/etiologia
Gadiformes/imunologia
Gadiformes/parasitologia
Antagonistas dos Receptores Histamínicos H1/administração & dosagem
Antagonistas dos Receptores Histamínicos H1/uso terapêutico
Seres Humanos
Hipodermóclise
Masculino
Metilprednisolona/administração & dosagem
Urticária/etiologia
Urticária/imunologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Arrhythmia Agents); 0 (Anti-Inflammatory Agents); 0 (Bronchodilator Agents); 0 (Histamine H1 Antagonists); 3Q9Q0B929N (dexchlorpheniramine); 3U6IO1965U (Chlorpheniramine); 50VV3VW0TI (Atenolol); X4W7ZR7023 (Methylprednisolone); YKH834O4BH (Epinephrine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170612
[St] Status:MEDLINE


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[PMID]:28538505
[Au] Autor:Öz S; Küpeli S; Sezgin G; Bayram I
[Ad] Endereço:Department of Pediatric Oncology and Bone Marrow Transplantation Unit, Cukurova University Faculty of Medicine, Adana, Turkey.
[Ti] Título:Thalassemia Major and Priapism: A Case Report of an Adolescent.
[So] Source:J Pediatr Hematol Oncol;39(6):e336-e337, 2017 Aug.
[Is] ISSN:1536-3678
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Priapism is defined as a prolonged pathologic penile erection without sexual stimulation. In children, priapism secondary to sickle cell disease or hematological malignancy is a frequent condition. Appropriate treatment of priapism varies; the treatment is primarily etiological, conservative management. In the present report, we aimed to present a case of asplenic thalassemia major who developed priapism, improved with hydration and ibuprofen treatment. Clinicians should take into account that priapism can be encountered in patients with thalassemia major. To our knowledge this is the second publication reporting the association between thalassemia major and priapism in childhood.
[Mh] Termos MeSH primário: Priapismo/etiologia
Talassemia beta/complicações
[Mh] Termos MeSH secundário: Adolescente
Seres Humanos
Hipodermóclise
Ibuprofeno/uso terapêutico
Masculino
Doenças do Pênis
Priapismo/terapia
Talassemia beta/terapia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
WK2XYI10QM (Ibuprofen)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170525
[St] Status:MEDLINE
[do] DOI:10.1097/MPH.0000000000000846


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[PMID]:28087221
[Au] Autor:Ohmura Y; Sasamori H; Tsutsui-Kimura I; Izumi T; Yoshida T; Yoshioka M
[Ad] Endereço:Department of Neuropharmacology, Hokkaido University, Graduate School of Medicine, Japan. Electronic address: gwd0701@yahoo.co.jp.
[Ti] Título:Varenicline provokes impulsive action by stimulating α4ß2 nicotinic acetylcholine receptors in the infralimbic cortex in a nicotine exposure status-dependent manner.
[So] Source:Pharmacol Biochem Behav;154:1-10, 2017 Mar.
[Is] ISSN:1873-5177
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Higher impulsivity is a risk factor for criminal involvement and drug addiction. Because nicotine administration enhances impulsivity, the effects of stop-smoking aids stimulating nicotinic acetylcholine receptors (nAChRs) on impulsivity must be determined in different conditions. Our goals were 1) to confirm the relationship between varenicline, a stop-smoking aid and α4ß2 nAChR partial agonist, and impulsivity, 2) to elucidate the mechanisms underlying the effects of varenicline, 3) to examine whether a low dose of varenicline that does not evoke impulsive action could block the stimulating effects of nicotine on impulsive action, 4) to determine whether the route of administration could modulate the effects of varenicline on impulsive action, and 5) to determine whether the effects of varenicline on impulsivity could be altered by smoking status. We used a 3-choice serial reaction time task to assess impulsivity and other cognitive functions in rats. Our findings are as follows: 1) acute subcutaneous (s.c.) injection of varenicline evoked impulsive action in a dose-dependent manner; 2) the effects of varenicline on impulsivity were blocked by the microinjection of dihydro-ß-erythroidine, a α4ß2 nAChR antagonist, into the infralimbic cortex; 3) the low dose of varenicline did not attenuate the effects of nicotine on impulsive action at all; 4) oral administration of varenicline evoked impulsive action in a similar manner to s.c. injection; and 5) the stimulating effects of varenicline on impulsive action were not observed in rats that received nicotine infusion for 8days or nicotine-abstinent rats after discontinuing infusion. Additionally, we found that oral varenicline administration enhanced attentional function whether nicotine was infused or not. Thus, although varenicline administration could be harmless to heavy smokers or ex-smokers, it could be difficult for non-smokers with respect to impulsivity, whereas it may be beneficial with respect to attentional function.
[Mh] Termos MeSH primário: Comportamento Impulsivo/efeitos dos fármacos
Lobo Límbico/efeitos dos fármacos
Nicotina/farmacologia
Receptores Nicotínicos/efeitos dos fármacos
Vareniclina/farmacologia
[Mh] Termos MeSH secundário: Administração Oral
Animais
Apetite/efeitos dos fármacos
Di-Hidro-beta-Eritroidina/farmacologia
Relação Dose-Resposta a Droga
Interações Medicamentosas
Hipodermóclise
Masculino
Microinjeções
Agonistas Nicotínicos/farmacologia
Ratos
Vareniclina/administração & dosagem
Vareniclina/antagonistas & inibidores
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nicotinic Agonists); 0 (Receptors, Nicotinic); 0 (nicotinic receptor alpha4beta2); 23255-54-1 (Dihydro-beta-Erythroidine); 6M3C89ZY6R (Nicotine); W6HS99O8ZO (Varenicline)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170115
[St] Status:MEDLINE


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[PMID]:28060004
[Au] Autor:Borzdynski CJ; McGuiness W; Miller C
[Ad] Endereço:Caroline J. Borzdynski, BN(Hons), RN, Discipline of Nursing, College of Science, Health and Engineering, La Trobe University, Melbourne, Victoria, Australia. William McGuiness, PhD, Nursing and Midwifery, College of Science, Health and Engineering, La Trobe University, Melbourne, Victoria, Australia. Charne Miller, PhD, Nursing and Midwifery, College of Science, Health and Engineering, La Trobe University, Melbourne, Victoria, Australia; and Alfred Clinical School, The Alfred Centre, Prahran, Victoria, Australia.
[Ti] Título:Emerging Technology for Enhanced Assessment of Skin Status.
[So] Source:J Wound Ostomy Continence Nurs;44(1):48-54, 2017 Jan/Feb.
[Is] ISSN:1528-3976
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pressure injury (PI) prevention has become a key nursing priority that requires clear identification of visual cues representative of PI risk. There is generalized agreement that erythema and skin wetness and/or maceration should be routinely examined by the clinician as part of PI risk assessment. Such an assessment is largely qualitative, deeply reliant on the perception and interpretation of the clinician. Consequently, skin parameters may be misinterpreted, underestimated, or even missed completely. Objective techniques are needed to augment accurate assessment of erythema and skin wetness and/or maceration. Biophysical skin analysis devices have been widely used in the cosmetic industry and clinical research to measure certain skin parameters for the purpose of skin health evaluation. This article describes 3 devices that enable noninvasive digital measurements of epidermal hydration, erythema, and epidermal lipids, respectively. The clinical application of biophysical skin analysis instruments in the assessment PI-related skin parameters could provide a feasible alternative to subjective assessment.
[Mh] Termos MeSH primário: Avaliação em Enfermagem/métodos
Literatura de Revisão como Assunto
Dermatopatias/diagnóstico
[Mh] Termos MeSH secundário: Seres Humanos
Hipodermóclise/enfermagem
Lesão por Pressão/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:170107
[St] Status:MEDLINE
[do] DOI:10.1097/WON.0000000000000293


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[PMID]:27988893
[Au] Autor:Fernández JR; Webb C; Rouzard K; Voronkov M; Huber KL; Stock JB; Stock M; Gordon JS; Perez E
[Ad] Endereço:Signum Dermalogix, 133 Wall Street, Princeton, NJ, 08540, USA.
[Ti] Título:N-Acetylglutaminoyl-S-farnesyl-L-cysteine (SIG-1191): an anti-inflammatory molecule that increases the expression of the aquaglyceroporin, aquaporin-3, in human keratinocytes.
[So] Source:Arch Dermatol Res;309(2):103-110, 2017 Mar.
[Is] ISSN:1432-069X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Isoprenylcysteine (IPC) small molecules were discovered as signal transduction modulating compounds ~25 years ago. More recently, IPC molecules have demonstrated antioxidant and anti-inflammatory properties in a variety of dermal cells as well as antimicrobial activity, representing a novel class of compounds to ameliorate skin conditions and disease. Here, we demonstrate a new IPC compound, N-acetylglutaminoyl-S-farnesyl-L-cysteine (SIG-1191), which inhibits UVB-induced inflammation blocking pro-inflammatory cytokine interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) production. To investigate further the previously reported hydrating potential of IPC compounds, SIG-1191 was tested for its ability to modulate aquaporin expression. Specifically, aquaporin 3 (AQP3) the most abundant aquaporin found in skin has been reported to play a key role in skin hydration, elasticity and barrier repair. Results show here for the first time that SIG-1191 increases AQP3 expression in both cultured normal human epidermal keratinocytes as well as when applied topically in a three-dimensional (3D) reconstructed human skin equivalent. Additionally, SIG-1191 dose dependently increased AQP3 protein levels, as determined by specific antibody staining, in the epidermis of the 3D skin equivalents. To begin to elucidate which signaling pathways SIG-1191 may be modulating to increase AQP3 levels, we used several pharmacological pathway inhibitors and determined that AQP3 expression is mediated by the Mitogen-activated protein kinase/Extracellular signal-regulated kinase kinase (MEK) pathway. Altogether, these data suggest SIG-1191 represents a new IPC derivative with anti-inflammatory activity that may also promote increased skin hydration based on its ability to increase AQP3 levels.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Aquaporina 3/metabolismo
Dipeptídeos/farmacologia
Interleucina-6/biossíntese
Queratinócitos/metabolismo
Lipopeptídeos/farmacologia
Fator de Necrose Tumoral alfa/biossíntese
Raios Ultravioleta/efeitos adversos
[Mh] Termos MeSH secundário: Aquaporina 3/biossíntese
MAP Quinases Reguladas por Sinal Extracelular/metabolismo
Seres Humanos
Hipodermóclise/métodos
Inflamação/tratamento farmacológico
Transdução de Sinais/efeitos dos fármacos
Pele/citologia
Pele/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Dipeptides); 0 (IL6 protein, human); 0 (Interleukin-6); 0 (Lipopeptides); 0 (N-acetylglutaminoyl-S-farnesylcysteine); 0 (Tumor Necrosis Factor-alpha); 158801-98-0 (Aquaporin 3); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161219
[St] Status:MEDLINE
[do] DOI:10.1007/s00403-016-1708-x


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[PMID]:27933463
[Au] Autor:Ahmeda AF; Rae MG; Al Otaibi MF; Anweigi LM; Johns EJ
[Ad] Endereço:Department of Physiology, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia. aahmeda@ksu.edu.sa.
[Ti] Título:Effect of tempol and tempol plus catalase on intra-renal haemodynamics in spontaneously hypertensive stroke-prone (SHSP) and Wistar rats.
[So] Source:J Physiol Biochem;73(2):207-214, 2017 May.
[Is] ISSN:1877-8755
[Cp] País de publicação:Spain
[La] Idioma:eng
[Ab] Resumo:Vasoconstriction within the renal medulla contributes to the development of hypertension. This study investigated the role of reactive oxygen species (ROS) in regulating renal medullary and cortical blood perfusion (MBP and CBP respectively) in both stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar rats. CBP and MBP were measured using a laser-Doppler flow meter before and after intra-renal infusion of tempol, the superoxide dismutase (SOD) mimetic or tempol plus catalase, the hydrogen peroxide-degrading enzyme. Tempol infusion significantly elevated blood perfusion within the renal medulla (MBP) in both SHRSP (by 43 ± 7%, P < 0.001) and Wistar rats (by 17 ± 2%, P < 0.05) but the magnitude of the increase was significantly greater in the SHRSP (P < 0.01). When the enzyme catalase and tempol were co-infused, MBP was again significantly increased in SHRSP (by 57 ± 6%, P < 0.001) and Wistar rats (by 33 ± 6%, P < 0.001), with a significantly greater increase in perfusion being induced in the SHRSP relative to the Wistar rats (P < 0.01). Notably, this increase was significantly greater than in those animals infused with tempol alone (P < 0.01). These results suggest that ROS plays a proportionally greater role in reducing renal vascular compliance, particularly within the renal medulla, in normotensive and hypertensive animals, with effects being greater in the hypertensive animals. This supports the hypothesis that SHRSP renal vasculature might be subjected to elevated level of oxidative stress relative to normotensive animals.
[Mh] Termos MeSH primário: Anti-Hipertensivos/uso terapêutico
Antioxidantes/uso terapêutico
Catalase/uso terapêutico
Óxidos N-Cíclicos/uso terapêutico
Hipertensão/tratamento farmacológico
Rim/efeitos dos fármacos
Circulação Renal/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Anti-Hipertensivos/administração & dosagem
Anti-Hipertensivos/efeitos adversos
Antioxidantes/administração & dosagem
Antioxidantes/efeitos adversos
Catalase/administração & dosagem
Catalase/efeitos adversos
Bovinos
Óxidos N-Cíclicos/administração & dosagem
Óxidos N-Cíclicos/efeitos adversos
Quimioterapia Combinada/efeitos adversos
Hipertensão/metabolismo
Hipertensão/fisiopatologia
Hipodermóclise
Rim/irrigação sanguínea
Rim/metabolismo
Rim/fisiopatologia
Medula Renal/irrigação sanguínea
Medula Renal/efeitos dos fármacos
Medula Renal/metabolismo
Medula Renal/fisiopatologia
Masculino
Estresse Oxidativo/efeitos dos fármacos
Ratos Endogâmicos SHR
Ratos Wistar
Espécies Reativas de Oxigênio/metabolismo
Marcadores de Spin
Acidente Vascular Cerebral/etiologia
Acidente Vascular Cerebral/prevenção & controle
Resistência Vascular/efeitos dos fármacos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antihypertensive Agents); 0 (Antioxidants); 0 (Cyclic N-Oxides); 0 (Reactive Oxygen Species); 0 (Spin Labels); EC 1.11.1.6 (Catalase); U78ZX2F65X (tempol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171111
[Lr] Data última revisão:
171111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161210
[St] Status:MEDLINE
[do] DOI:10.1007/s13105-016-0541-1


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[PMID]:27998296
[Au] Autor:Vera L; Oddo S; Di Iorgi N; Bentivoglio G; Giusti M
[Ad] Endereço:Department of Internal Medicine, Genoa University, Viale Benedetto XV 6, 16132, Genoa, Italy.
[Ti] Título:Primary hyperparathyroidism in pregnancy treated with cinacalcet: a case report and review of the literature.
[So] Source:J Med Case Rep;10(1):361, 2016 Dec 20.
[Is] ISSN:1752-1947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The efficacy and safety of various modes of medical treatment for primary hyperparathyroidism in pregnancy are largely unknown. CASE PRESENTATION: We report the case of a 34-year-old white woman with primary hyperparathyroidism symptomatic for nephrolithiasis. Her serum calcium was 3.15 mmol/l and parathyroid hormone was 109.0 ng/L. Neck imaging found no pathological parathyroid tissue. Cinacalcet and cholecalciferol were started. She became pregnant 17 months later. The calcimimetic was stopped. During pregnancy, she was admitted for hydration administered intravenously two to three times per week. In her 24 week of pregnancy, cinacalcet was restarted. In her 32nd week, a cesarean section was carried out as planned. CONCLUSIONS: Only three cases of primary hyperparathyroidism in women on cinacalcet therapy in pregnancy have been published in the literature. In the present case, hydration was useful in controlling serum calcium. Cinacalcet therapy helped to control serum calcium.
[Mh] Termos MeSH primário: Calcimiméticos/uso terapêutico
Cloridrato de Cinacalcete/uso terapêutico
Hiperparatireoidismo Primário/tratamento farmacológico
Hipodermóclise/métodos
Complicações na Gravidez/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Cesárea
Feminino
Seres Humanos
Hiperparatireoidismo Primário/sangue
Hiperparatireoidismo Primário/complicações
Recém-Nascido
Masculino
Gravidez
Complicações na Gravidez/sangue
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Calcimimetic Agents); 1K860WSG25 (Cinacalcet Hydrochloride)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161222
[St] Status:MEDLINE
[do] DOI:10.1186/s13256-016-1093-2


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[PMID]:27595109
[Au] Autor:Carrick MM; Leonard J; Slone DS; Mains CW; Bar-Or D
[Ad] Endereço:Trauma Services Department, The Medical Center of Plano, 3901 W. 15th Street, Plano, TX 75075, USA.
[Ti] Título:Hypotensive Resuscitation among Trauma Patients.
[So] Source:Biomed Res Int;2016:8901938, 2016.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hemorrhagic shock is a principal cause of death among trauma patients within the first 24 hours after injury. Optimal fluid resuscitation strategies have been examined for nearly a century, more recently with several randomized controlled trials. Hypotensive resuscitation, also called permissive hypotension, is a resuscitation strategy that uses limited fluids and blood products during the early stages of treatment for hemorrhagic shock. A lower-than-normal blood pressure is maintained until operative control of the bleeding can occur. The randomized controlled trials examining restricted fluid resuscitation have demonstrated that aggressive fluid resuscitation in the prehospital and hospital setting leads to more complications than hypotensive resuscitation, with disparate findings on the survival benefit. Since the populations studied in each randomized controlled trial are slightly different, as is the timing of intervention and targeted vitals, there is still a need for a large, multicenter trial that can examine the benefit of hypotensive resuscitation in both blunt and penetrating trauma patients.
[Mh] Termos MeSH primário: Hipotensão/complicações
Hipotensão/terapia
Ressuscitação
Ferimentos e Lesões/complicações
Ferimentos e Lesões/terapia
[Mh] Termos MeSH secundário: Seres Humanos
Hipodermóclise
Guias de Prática Clínica como Assunto
Ensaios Clínicos Controlados Aleatórios como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160906
[St] Status:MEDLINE
[do] DOI:10.1155/2016/8901938


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[PMID]:27444408
[Au] Autor:Smeets XJ; da Costa DW; Besselink MG; Bruno MJ; Fockens P; Mulder CJ; van der Hulst RW; Vleggaar FP; Timmer R; Drenth JP; van Geenen EJ
[Ad] Endereço:Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, Gelderland, The Netherlands.
[Ti] Título:Systematic review: periprocedural hydration in the prevention of post-ERCP pancreatitis.
[So] Source:Aliment Pharmacol Ther;44(6):541-53, 2016 Sep.
[Is] ISSN:1365-2036
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: With an overall incidence of 3.5%, pancreatitis is the most frequent complication of endoscopic retrograde cholangiopancreatography (ERCP). Periprocedural hydration may prevent post-ERCP pancreatitis by maintaining pancreatic microperfusion, thereby inhibiting the pancreatic inflammatory response. However, the evidence for periprocedural hydration as a preventive measure is unclear. AIM: To conduct a systematic review to assess the evidence regarding periprocedural hydration as a preventive measure for post-ERCP pancreatitis. METHODS: We searched PubMed and EMBASE databases and adhered to the PRISMA guidelines. We included studies addressing periprocedural hydration as a preventive measure to reduce frequency and severity of post-ERCP pancreatitis. Study quality was assessed by using the MINORS and Cochrane Collaboration's tool. RESULTS: Six studies with a total of 1102 patients were included. Two randomised controlled trials reported a decreased incidence of post-ERCP pancreatitis after hydration: 0% vs. 17% (P = 0.016) and 5.3% vs. 22.7% (P = 0.002). A third trial and two case-controls studies did not report significant differences. Two retrospective studies found that patients with mild post-ERCP pancreatitis had received significantly more fluids during (mean 940 mL vs. 810 mL; P = 0.031) or after ERCP (median 2834 mL vs. 2044 mL; P < 0.02) compared to patients with moderate/severe disease. Adverse events of periprocedural hydration were not reported in any of the included studies. The different methodologies of the included studies precluded a formal data synthesis. CONCLUSIONS: There is some evidence to suggest that hydration affords protection against post-ERCP pancreatitis, but study heterogeneity precludes firm conclusions. Adequately powered randomised trials are needed to evaluate the preventive effect of periprocedural hydration.
[Mh] Termos MeSH primário: Colangiopancreatografia Retrógrada Endoscópica/efeitos adversos
Hipodermóclise
Pancreatite/etiologia
Pancreatite/prevenção & controle
Assistência Perioperatória/métodos
Complicações Pós-Operatórias/prevenção & controle
[Mh] Termos MeSH secundário: Bases de Dados Factuais
Feminino
Seres Humanos
Hipodermóclise/métodos
Incidência
Masculino
Pancreatite/epidemiologia
Complicações Pós-Operatórias/epidemiologia
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160723
[St] Status:MEDLINE
[do] DOI:10.1111/apt.13744



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