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[PMID]:27777173
[Au] Autor:Poole DS; Doorenweerd N; Plomp JJ; Mahfouz A; Reinders MJT; van der Weerd L
[Ad] Endereço:Department of Radiology, Leiden University Medical Centre, Leiden, Netherlands. Electronic address: D.Poole@lumc.nl.
[Ti] Título:Continuous infusion of manganese improves contrast and reduces side effects in manganese-enhanced magnetic resonance imaging studies.
[So] Source:Neuroimage;147:1-9, 2017 Feb 15.
[Is] ISSN:1095-9572
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The ability to administer systemically high doses of manganese as contrast agent while circumventing its toxicity is of particular interest for exploratory MRI studies of the brain. Administering low doses either repeatedly or continuously over time has been shown to enable the acquisition of satisfactory MRI images of the mouse brain without apparent side effects. Here we have systematically compared the obtained MRI contrast and recorded potential systemic side effects such as stress response and muscle strength impairment in relation to the achieved contrast. We show in mice that administering MnCl via osmotic infusion pumps allows for a side-effect free delivery of a high cumulative dose of manganese chloride (480mg/kg bodyweight in 8 days). High contrast in MRI was achieved while we did not observe the weight loss or distress seen in other studies where mice received manganese via fractionated intraperitoneal injections of lower doses of manganese. As the normal daily conduct of the mice was not affected, this new manganese delivery method might be of particular use to study brain activity over several days. This may facilitate the phenotyping of new transgenic mouse models, the study of chronic disease models and the monitoring of changes in brain activity in long-term behavioral studies.
[Mh] Termos MeSH primário: Cloretos/administração & dosagem
Cloretos/farmacologia
Meios de Contraste/administração & dosagem
Meios de Contraste/farmacologia
Imagem por Ressonância Magnética/métodos
Compostos de Manganês/administração & dosagem
Compostos de Manganês/farmacologia
[Mh] Termos MeSH secundário: Animais
Cloretos/efeitos adversos
Meios de Contraste/efeitos adversos
Corticosterona/sangue
Aumento da Imagem
Bombas de Infusão
Infusões Intravenosas
Injeções Intraperitoneais
Masculino
Compostos de Manganês/efeitos adversos
Camundongos
Camundongos Endogâmicos C57BL
Força Muscular/efeitos dos fármacos
Estresse Psicológico/induzido quimicamente
Estresse Psicológico/psicologia
Perda de Peso/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorides); 0 (Contrast Media); 0 (Manganese Compounds); QQE170PANO (manganese chloride); W980KJ009P (Corticosterone)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


  2 / 29425 MEDLINE  
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[PMID]:27775689
[Au] Autor:Yang J; Wang T; Li Y; Yao W; Ji X; Wu Q; Han L; Han R; Yan W; Yuan J; Ni C
[Ad] Endereço:Department of Occupational Medicine and Environmental Health and Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China.
[Ti] Título:Earthworm extract attenuates silica-induced pulmonary fibrosis through Nrf2-dependent mechanisms.
[So] Source:Lab Invest;96(12):1279-1300, 2016 12.
[Is] ISSN:1530-0307
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Silicosis is an occupational pulmonary fibrosis caused by inhalation of silica (SiO ) and there are no ideal drugs to treat this disease. Earthworm extract (EE), a natural nutrient, has been reported to have anti-inflammatory, antioxidant, and anti-apoptosis effects. The purpose of the current study was to test the protective effects of EE against SiO -induced pulmonary fibrosis and to explore the underlying mechanisms using both in vivo and in vitro models. We found that treatment with EE significantly reduced lung inflammation and fibrosis and improved lung structure and function in SiO -instilled mice. Further mechanistic investigations revealed that EE administration markedly inhibited SiO -induced oxidative stress, mitochondrial apoptotic pathway, and epithelial-mesenchymal transition in HBE and A549 cells. Furthermore, we demonstrate that Nrf2 activation partly mediates the interventional effects of EE against SiO -induced pulmonary fibrosis. Our study has identified EE to be a potential anti-oxidative, anti-inflammatory, and anti-fibrotic drug for silicosis.
[Mh] Termos MeSH primário: Antioxidantes/uso terapêutico
Modelos Animais de Doenças
Pulmão/efeitos dos fármacos
Materia Medica/uso terapêutico
Oligoquetos/química
Fibrose Pulmonar/prevenção & controle
Silicose/tratamento farmacológico
Extratos de Tecidos/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios não Esteroides/administração & dosagem
Anti-Inflamatórios não Esteroides/farmacologia
Anti-Inflamatórios não Esteroides/uso terapêutico
Antioxidantes/administração & dosagem
Antioxidantes/farmacologia
Apoptose/efeitos dos fármacos
Linhagem Celular
Células Cultivadas
Transição Epitelial-Mesenquimal/efeitos dos fármacos
Injeções Intraperitoneais
Pulmão/metabolismo
Pulmão/patologia
Pulmão/fisiopatologia
Masculino
Materia Medica/administração & dosagem
Materia Medica/farmacologia
Camundongos Endogâmicos C57BL
Fator 2 Relacionado a NF-E2/agonistas
Fator 2 Relacionado a NF-E2/antagonistas & inibidores
Fator 2 Relacionado a NF-E2/genética
Fator 2 Relacionado a NF-E2/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Fibrose Pulmonar/etiologia
Fibrose Pulmonar/imunologia
Interferência de RNA
Distribuição Aleatória
Mucosa Respiratória/citologia
Mucosa Respiratória/efeitos dos fármacos
Mucosa Respiratória/metabolismo
Mucosa Respiratória/patologia
Silicose/metabolismo
Silicose/patologia
Silicose/fisiopatologia
Organismos Livres de Patógenos Específicos
Extratos de Tecidos/administração & dosagem
Extratos de Tecidos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Antioxidants); 0 (Materia Medica); 0 (NF-E2-Related Factor 2); 0 (Tissue Extracts)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1038/labinvest.2016.101


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[PMID]:28460583
[Au] Autor:Nielsen BS; Larsen EH; Ladefoged O; Lam HR
[Ad] Endereço:1 Environment and Toxicology, DHI, Hørsholm, Denmark.
[Ti] Título:Subchronic, Low-Level Intraperitoneal Injections of Manganese (IV) Oxide and Manganese (II) Chloride Affect Rat Brain Neurochemistry.
[So] Source:Int J Toxicol;36(3):239-251, 2017 May/Jun.
[Is] ISSN:1092-874X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Manganese (Mn) is neurotoxic and can induce manganism, a Parkinson-like disease categorized as being a serious central nervous system irreversible neurodegenerative disease. An increased risk of developing symptoms of Parkinson disease has been linked to work-related exposure, for example, for workers in agriculture, horticulture, and people living near areas with frequent use of Mn-containing pesticides. In this study, the focus was placed on neurochemical effects of Mn. Rats were dosed intraperitoneally with 0.9% NaCl (control), 1.22 mg Mn (as MnO )/kg bodyweight (bw)/day, or 2.5 mg Mn (as MnCl )/kg bw/day for 7 d/wk for 8 or 12 weeks. This dosing regimen adds relevant new knowledge about Mn neurotoxicity as a consequence of low-dose subchronic Mn dosing. Manganese concentrations increased in the striatum, the rest of the brain, and in plasma, and regional brain neurotransmitter concentrations, including noradrenaline, dopamine (DA), 5-hydroxytrytamine, glutamate, taurine, and γ-amino butyric acid, and the activity of acetylcholinesterase changed. Importantly, a target parameter for Parkinson disease and manganism, the striatal DA concentration, was reduced after 12 weeks of dosing with MnCl . Plasma prolactin concentration was not significantly affected due to a potentially reduced dopaminergic inhibition of the prolactin release from the anterior hypophysis. No effects on the striatal α-synuclein and synaptophysin protein levels were detected.
[Mh] Termos MeSH primário: Química Encefálica/efeitos dos fármacos
Encéfalo/efeitos dos fármacos
Cloretos/toxicidade
Óxidos/toxicidade
[Mh] Termos MeSH secundário: Acetilcolinesterase/metabolismo
Animais
Encéfalo/metabolismo
Cloretos/sangue
Cloretos/farmacocinética
Dopamina/metabolismo
Ácido Glutâmico/metabolismo
Injeções Intraperitoneais
Masculino
Manganês/sangue
Manganês/metabolismo
Compostos de Manganês/sangue
Compostos de Manganês/farmacocinética
Norepinefrina/metabolismo
Óxidos/sangue
Óxidos/farmacocinética
Ratos Sprague-Dawley
Serotonina/metabolismo
Taurina/metabolismo
Ácido gama-Aminobutírico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorides); 0 (Manganese Compounds); 0 (Oxides); 1EQV5MLY3D (Taurine); 333DO1RDJY (Serotonin); 3KX376GY7L (Glutamic Acid); 42Z2K6ZL8P (Manganese); 56-12-2 (gamma-Aminobutyric Acid); 64J2OA7MH3 (manganese oxide); EC 3.1.1.7 (Acetylcholinesterase); QQE170PANO (manganese chloride); VTD58H1Z2X (Dopamine); X4W3ENH1CV (Norepinephrine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1177/1091581817704378


  4 / 29425 MEDLINE  
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[PMID]:29249626
[Au] Autor:Sekioka R; Honjo E; Honda S; Fuji H; Akashiba H; Mitani Y; Yamasaki S
[Ad] Endereço:Drug Discovery Research, Astellas Pharma Inc., 21, Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan. Electronic address: ryuichi.sekioka@astellas.com.
[Ti] Título:Discovery of novel scaffolds for γ-secretase modulators without an arylimidazole moiety.
[So] Source:Bioorg Med Chem;26(2):435-442, 2018 01 15.
[Is] ISSN:1464-3391
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Gamma-secretase modulators (GSMs) selectively inhibit the production of amyloid-ß 42 (Aß42) and may therefore be useful in the management of Alzheimer's disease. Most heterocyclic GSMs that are not derived from nonsteroidal anti-inflammatory drugs contain an arylimidazole moiety that potentially inhibits cytochrome P450 (CYP) activity. Here, we discovered imidazopyridine derivatives that represent a new class of scaffold for GSMs, which do not have a strongly basic end group such as arylimidazole. High-throughput screening identified 2-methyl-8-[(2-methylbenzyl)oxy]-3-(pyridin-4-yl)imidazo[1,2-a]pyridine (3a), which inhibited the cellular production of Aß42 (IC = 7.1 µM) without changing total production of Aß. Structural optimization of this series of compounds identified 5-[8-(benzyloxy)-2-methylimidazo[1,2-a]pyridin-3-yl]-2-ethylisoindolin-1-one (3m) as a potent inhibitor of Aß42 (IC = 0.39 µM) but not CYP3A4. Further, 3m demonstrated a sustained pharmacokinetic profile in mice and sufficiently penetrated the brain.
[Mh] Termos MeSH primário: Secretases da Proteína Precursora do Amiloide/antagonistas & inibidores
Descoberta de Drogas
Compostos Heterocíclicos/farmacologia
Imidazóis/farmacologia
Piridinas/farmacologia
[Mh] Termos MeSH secundário: Administração Oral
Secretases da Proteína Precursora do Amiloide/metabolismo
Peptídeos beta-Amiloides/antagonistas & inibidores
Peptídeos beta-Amiloides/biossíntese
Animais
Linhagem Celular Tumoral
Citocromo P-450 CYP3A/metabolismo
Relação Dose-Resposta a Droga
Compostos Heterocíclicos/administração & dosagem
Compostos Heterocíclicos/química
Seres Humanos
Imidazóis/administração & dosagem
Imidazóis/química
Injeções Intraperitoneais
Masculino
Camundongos
Camundongos Endogâmicos
Microssomos Hepáticos/química
Microssomos Hepáticos/metabolismo
Modelos Moleculares
Estrutura Molecular
Fragmentos de Peptídeos/antagonistas & inibidores
Fragmentos de Peptídeos/biossíntese
Piridinas/administração & dosagem
Piridinas/química
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amyloid beta-Peptides); 0 (Heterocyclic Compounds); 0 (Imidazoles); 0 (Peptide Fragments); 0 (Pyridines); 0 (amyloid beta-protein (1-42)); 0 (imidazopyridine); EC 1.14.14.1 (Cytochrome P-450 CYP3A); EC 1.14.14.1 (cytochrome P450 3A4, mouse); EC 3.4.- (Amyloid Precursor Protein Secretases)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE


  5 / 29425 MEDLINE  
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[PMID]:29247653
[Au] Autor:Nishigawa T; Nagamachi S; Chowdhury VS; Yasuo S; Furuse M
[Ad] Endereço:Laboratory of Regulation in Metabolism and Behavior, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan.
[Ti] Título:Taurine and ß-alanine intraperitoneal injection in lactating mice modifies the growth and behavior of offspring.
[So] Source:Biochem Biophys Res Commun;495(2):2024-2029, 2018 01 08.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Taurine, one of the sulfur-containing amino acids, has several functions in vivo. It has been reported that taurine acts on γ-aminobutyric acid receptors as an agonist and to promote inhibitory neurotransmission. Milk, especially colostrum, contains taurine and it is known that milk taurine is essential for the normal development of offspring. ß-Alanine is transported via a taurine transporter and a protein-assisted amino acid transporter, the same ones that transport taurine. The present study aimed to investigate whether the growth and behavior of offspring could be altered by modification of the taurine concentration in milk. Pregnant ICR mice were separated into 3 groups: 1) a control group, 2) a taurine group, and 3) a ß-alanine group. During the lactation periods, dams were administered, respectively, with 0.9% saline (10 ml/kg, i.p.), taurine dissolved in 0.9% saline (43 mg/10 ml/kg, i.p.), or ß-alanine dissolved in 0.9% saline (31 mg/10 ml/kg, i.p.). Interestingly, the taurine concentration in milk was significantly decreased by the administration of ß-alanine, but not altered by the taurine treatment. The body weight of offspring was significantly lower in the ß-alanine group. ß-Alanine treatment caused a significant decline in taurine concentration in the brains of offspring, and it was negatively correlated with total distance traveled in the open field test at postnatal day 15. Thus, decreased taurine concentration in the brain induced hyperactivity in offspring. These results suggested that milk taurine may have important role of regulating the growth and behavior of offspring.
[Mh] Termos MeSH primário: Comportamento Animal/efeitos dos fármacos
Peso Corporal/efeitos dos fármacos
Lactação/fisiologia
Troca Materno-Fetal/fisiologia
Taurina/administração & dosagem
beta-Alanina/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Comportamento Animal/fisiologia
Peso Corporal/fisiologia
Relação Dose-Resposta a Droga
Feminino
Injeções Intraperitoneais
Camundongos
Camundongos Endogâmicos ICR
Leite/química
Gravidez
Taurina/química
Resultado do Tratamento
beta-Alanina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
11P2JDE17B (beta-Alanine); 1EQV5MLY3D (Taurine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE


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[PMID]:28458349
[Au] Autor:Matsutani T; Tamura K; Kutsukake M; Matsuda A; Tachikawa E; Uchida E
[Ad] Endereço:Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School.
[Ti] Título:Impact of Pioglitazone on Macrophage Dynamics in Adipose Tissues of Cecal Ligation and Puncture-Treated Mice.
[So] Source:Biol Pharm Bull;40(5):638-644, 2017.
[Is] ISSN:1347-5215
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Pioglitazone improves sepsis-induced organ injury accompanied with anti-inflammatory effects on visceral adipose tissue. However, its action in adipose immune cells remains to be ascertained. We investigated the effects of pioglitazone on visceral adipose macrophage population and polarisation in cecal ligation and puncture (CLP)-induced sepsis mice. Eight-week-old male mice were assigned to 3 groups: 1) sham-operated group, 2) CLP group, or 3) pioglitazone-treated CLP group. Pioglitazone (10 mg/kg) was injected intraperitonally for 7 d and CLP surgery was performed. Visceral adipose tissues were collected 24 h after the surgery. mRNA expression of several macrophage markers (inducible nitric oxide synthase (iNOS) for M1, arginase1 (Arg1) and interleukin (IL)-10 for M2, CD163 and F4/80 for mature macrophages) and inflammatory adipokines (IL-6, monocyte chemoattractant protein-1: MCP-1) was quantified by real-time RT-PCR. Tissue sections were subjected to the immunohistochemical analysis and the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL) assay. CLP significantly enhanced Arg1, IL-10 and iNOS mRNA expressions as compared with the sham group, and pioglitazone significantly increased the mRNA level of CD163 and F4/80 in CLP mice. Expression of IL-6 and MCP-1 stimulated by CLP was reduced by pioglitazone treatment. Increased CD11b/c- and CD163-positive cells as well as apoptotic cells were observed in the CLP group and the pioglitazone-treated group. The data indicate that M1/M2 macrophage activation of visceral adipose tissues is induced in CLP-induced mice, and the function of macrophages recruited from surrounding organs may be modulated by pioglitazone treatment.
[Mh] Termos MeSH primário: Hipoglicemiantes/farmacologia
Gordura Intra-Abdominal/patologia
Macrófagos/efeitos dos fármacos
Sepse/patologia
Tiazolidinedionas/farmacologia
[Mh] Termos MeSH secundário: Adipocinas/metabolismo
Animais
Arginase/análise
Biomarcadores/análise
Ceco
Quimiocina CCL2/metabolismo
Hipoglicemiantes/administração & dosagem
Injeções Intraperitoneais
Interleucina-10/sangue
Ligadura
Masculino
Camundongos
Punções
Tiazolidinedionas/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adipokines); 0 (Biomarkers); 0 (Ccl2 protein, mouse); 0 (Chemokine CCL2); 0 (Hypoglycemic Agents); 0 (IL10 protein, mouse); 0 (Thiazolidinediones); 130068-27-8 (Interleukin-10); EC 3.5.3.1 (Arg1 protein, mouse); EC 3.5.3.1 (Arginase); X4OV71U42S (pioglitazone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1248/bpb.b16-00883


  7 / 29425 MEDLINE  
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[PMID]:29235966
[Au] Autor:Myronovskij SL; Boiko NM; Chumak VV; Shorobura MS; Lootsyk MD; Stoika RS; Kit YY
[Ti] Título:The characteristics of antibodies of mice immunized by human unconventional myosin 1c.
[So] Source:Ukr Biochem J;88(6):63-9, 2016 Nov-Dec.
[Is] ISSN:2409-4943
[Cp] País de publicação:Ukraine
[La] Idioma:eng
[Ab] Resumo:Specific antibodies produced against a protein of interest are invaluable tools for monitoring the protein structure, intracellular location and biological activity. Inoculation of murine lymphoma cells into the peritoneal cavity of immunized mice provides generation of ascitic fluid containing a significant amount of antibody with desired antigen specificity. Here we demonstrated that the intraperitoneal administration of murine lymphoma NK/Ly cells in mice immunized with 48 kDa isoform of human blood serum unconventional myosin 1c leads to generation of ascitic fluid that contained specific IgG-antibodies. These antibodies were capable of binding of the unconventional myosin 1c isolated from blood serum of patients with multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosis, and could be used for diagnostics of several autoimmune diseases, the multiple sclerosis in particular.
[Mh] Termos MeSH primário: Antígenos/administração & dosagem
Líquido Ascítico/imunologia
Imunoglobulina G/isolamento & purificação
Linfoma/imunologia
Miosina Tipo I/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Artrite Reumatoide/sangue
Artrite Reumatoide/diagnóstico
Líquido Ascítico/química
Feminino
Seres Humanos
Imunização
Imunoglobulina G/biossíntese
Imunoglobulina G/química
Injeções Intraperitoneais
Lúpus Eritematoso Sistêmico/sangue
Lúpus Eritematoso Sistêmico/diagnóstico
Linfoma/patologia
Camundongos
Camundongos Endogâmicos BALB C
Esclerose Múltipla/sangue
Esclerose Múltipla/diagnóstico
Transplante de Neoplasias
Células Tumorais Cultivadas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens); 0 (Immunoglobulin G); EC 3.6.1.- (Myosin Type I); EC 3.6.1.3 (MYO1C protein, human)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.15407/ubj88.06.063


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[PMID]:28458506
[Au] Autor:Qi S; Wang C; Song D; Song Y; Dunaief JL
[Ad] Endereço:Department of Ophthalmology, The Second Hospital of Jilin University, Jilin, China.
[Ti] Título:Intraperitoneal injection of (-)-Epigallocatechin-3-gallate protects against light-induced photoreceptor degeneration in the mouse retina.
[So] Source:Mol Vis;23:171-178, 2017.
[Is] ISSN:1090-0535
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: (-)-epigallocatechin-3-gallate (EGCG), a major catechin component of green tea, is reported to delay or prevent certain forms of cancer, arthritis, cardiovascular disease, and neurodegenerative disorders. In this study, we determined if systemically administered EGCG could protect the retina against light damage (LD) in mice. METHODS: BALB/cJ mice were treated with either EGCG or saline via intraperitoneal (IP) injection, and then placed under constant cool white light-emitting diode (LED) light (10,000 lux) for 5 h. Retinal structure and function were evaluated using optical coherence tomography (OCT), histology, and electroretinography (ERG) 7 days after LD. In addition, the mRNAs of several oxidative stress genes were quantified by qPCR before LD and 24 h after LD. RESULTS: OCT and photomicrographs of mouse retinas showed morphologic protection of photoreceptors. Mice in the EGCG group had significantly higher ERG amplitudes for all three wave types compared with mice in the saline control group, which indicated that EGCG protected retinal function. Furthermore, qPCR results showed that EGCG administration can increase the mRNA level of the antioxidant gene before LD and 24 h after LD. CONCLUSIONS: The IP injection of EGCG attenuated the detrimental effects of bright light on the retinas of BALB/cJ mice by protecting the structure and function of the retina.
[Mh] Termos MeSH primário: Antioxidantes/uso terapêutico
Catequina/análogos & derivados
Luz/efeitos adversos
Células Fotorreceptoras de Vertebrados/efeitos da radiação
Lesões Experimentais por Radiação/prevenção & controle
Degeneração Retiniana/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Antioxidantes/administração & dosagem
Catequina/administração & dosagem
Catequina/uso terapêutico
Eletrorretinografia
Injeções Intraperitoneais
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Estresse Oxidativo/genética
RNA Mensageiro/genética
Lesões Experimentais por Radiação/etiologia
Lesões Experimentais por Radiação/fisiopatologia
Reação em Cadeia da Polimerase em Tempo Real
Retina/fisiopatologia
Degeneração Retiniana/etiologia
Degeneração Retiniana/fisiopatologia
Superóxido Dismutase/genética
Tomografia de Coerência Óptica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (RNA, Messenger); 8R1V1STN48 (Catechin); BQM438CTEL (epigallocatechin gallate); EC 1.15.1.1 (Superoxide Dismutase); EC 1.15.1.1 (superoxide dismutase 2)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


  9 / 29425 MEDLINE  
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[PMID]:29202404
[Au] Autor:Zhu W; Liu X; Wang Y; Tong Y; Hu Y
[Ad] Endereço:Zhejiang Academy of Traditional Chinese Medicine, Hangzhou 310007, China; ZJU-ENS Joint Laboratory of Medicinal Chemistry, Zhejiang University, Hangzhou 310058, China.
[Ti] Título:Discovery of a novel series of α-terpineol derivatives as promising anti-asthmatic agents: Their design, synthesis, and biological evaluation.
[So] Source:Eur J Med Chem;143:419-425, 2018 Jan 01.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:A series of novel α-terpineol derivatives were designed and synthesized through structural derivatization of the tertiary hydroxyl moiety or reduction of the double bond. Of the resulting compounds, eight compounds enhanced relaxation of airway smooth muscle (ASM) compared to the α-terpineol precursor, and four compounds (4a, 4d, 4e, and 4i)were superior or comparable to aminophylline at a concentration of 0.75 mmol/L. Assays for 3'-5'-Cyclic adenosine monophpsphate (cAMP) activation revealed that some representative α-terpineol derivatives in this series were capable of upregulating the level of cAMP in ASM cells. Further in vivo investigation using the asthmatic rat model, illustrated that treatment with the compounds 4a and 4e resulted in significantly lowered lung resistance (RL) and enhanced dynamic lung compliance (Cldyn), two important parameters for lung fuction. Moreover, treatment with 4e downregulated the levels of both IL-4 and IL-17. Due to its several favorable physiological functions, including ASM relaxation activity, cAMP activation capability, and in vivo anti-asthmatic efficacy, 4e is a promising remedy for bronchial asthma, meriting extensive development.
[Mh] Termos MeSH primário: Antiasmáticos/uso terapêutico
Asma/tratamento farmacológico
Cicloexenos/uso terapêutico
Descoberta de Drogas
Monoterpenos/uso terapêutico
[Mh] Termos MeSH secundário: Administração Oral
Hidróxido de Alumínio/administração & dosagem
Animais
Antiasmáticos/administração & dosagem
Antiasmáticos/química
Asma/induzido quimicamente
Cicloexenos/administração & dosagem
Cicloexenos/química
Relação Dose-Resposta a Droga
Cobaias
Injeções Intraperitoneais
Masculino
Estrutura Molecular
Monoterpenos/administração & dosagem
Monoterpenos/química
Ovalbumina/administração & dosagem
Ratos
Ratos Sprague-Dawley
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Asthmatic Agents); 0 (Cyclohexenes); 0 (Monoterpenes); 21334LVV8W (alpha-terpineol); 5QB0T2IUN0 (Aluminum Hydroxide); 9006-59-1 (Ovalbumin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180101
[Lr] Data última revisão:
180101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE


  10 / 29425 MEDLINE  
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[PMID]:28453256
[Au] Autor:Cao P; Mooney R; Tirughana R; Abidi W; Aramburo S; Flores L; Gilchrist M; Nwokafor U; Haber T; Tiet P; Annala AJ; Han E; Dellinger T; Aboody KS; Berlin JM
[Ti] Título:Intraperitoneal Administration of Neural Stem Cell-Nanoparticle Conjugates Targets Chemotherapy to Ovarian Tumors.
[So] Source:Bioconjug Chem;28(6):1767-1776, 2017 06 21.
[Is] ISSN:1520-4812
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ovarian cancer is particularly aggressive once it has metastasized to the abdominal cavity (stage III). Intraperitoneal (IP) as compared to intravenous (IV) administration of chemotherapy improves survival for stage III ovarian cancer, demonstrating that concentrating chemotherapy at tumor sites has therapeutic benefit; unfortunately, IP therapy also increases toxic side effects, thus preventing its completion in many patients. The ability to target chemotherapy selectively to ovarian tumors while sparing normal tissue would improve efficacy and decrease toxicities. We have previously shown that tumor-tropic neural stem cells (NSCs) dramatically improve the intratumoral distribution of nanoparticles (NPs) when given intracerebrally near an orthotopic brain tumor or into a flank xenograft tumor. Here, we show that NPs either conjugated to the surface of NSCs or loaded within the cells are selectively delivered to and distributed within ovarian tumors in the abdominal cavity following IP injection, with no evidence of localization to normal tissue. IP administration is significantly more effective than IV administration, and NPs carried by NSCs show substantially deeper penetration into tumors than free NPs. The NSCs and NPs target and localize to ovarian tumors within 1 h of administration. Pt-loaded silica NPs (SiNP[Pt]) were developed that can be transported in NSCs, and it was found that the NSC delivery of SiNP[Pt] (NSC-SiNP[Pt]) results in higher levels of Pt in tumors as compared to free drug or SiNP[Pt]. To the best of our knowledge, this work represents the first demonstration that cells given IP can target the delivery of drug-loaded NPs.
[Mh] Termos MeSH primário: Sistemas de Liberação de Medicamentos/métodos
Nanopartículas/química
Células-Tronco Neurais/transplante
Neoplasias Ovarianas/tratamento farmacológico
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Injeções Intraperitoneais
Nanopartículas/administração & dosagem
Células-Tronco Neurais/química
Compostos de Platina/administração & dosagem
Compostos de Platina/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Platinum Compounds)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1021/acs.bioconjchem.7b00237



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