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[PMID]:28693628
[Au] Autor:Bola S; Rashid M; Hickey S
[Ad] Endereço:Department of Otolaryngology,Torbay and South Devon NHS Foundation Trust,Torquay,UK.
[Ti] Título:Optimising the use of otowicks in otitis externa.
[So] Source:J Laryngol Otol;131(9):809-812, 2017 Sep.
[Is] ISSN:1748-5460
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Otowicks are used to treat otitis externa with significant ear canal oedema. This study investigates how well drops penetrate through to reach the deep canal and whether it is safe to leave otowicks in the canal for more than 2 days. METHODS: Sterile otowicks were inserted into mock ear canals and vertically over pseudomonas-seeded agar plates whilst gentamicin or ciprofloxacin drops were administered. The time taken for drops to penetrate through the otowick was recorded. Separately, pseudomonas-seeded otowicks were treated with saline or antibacterial drops. The penetrating drops were observed for bacterial growth on sterile agar. RESULTS: It took six drops before penetration occurred for both antibiotics. When sterile saline drops were applied to bacterially contaminated otowicks, the penetrating drops displayed bacterial growth on agar, indicating that pseudomonas penetrated through the otowick. However, when antibiotic drops were applied, penetrating drops showed no bacterial growth on the corresponding agar plate. CONCLUSION: Bacteria can penetrate otowicks but this is prevented by continuous application of antibacterial ear drops. Ear wicks need priming with six drops before starting a regimen, so that the initial dose is fully absorbed.
[Mh] Termos MeSH primário: Ciprofloxacino/administração & dosagem
Gentamicinas/administração & dosagem
Otite Externa/tratamento farmacológico
[Mh] Termos MeSH secundário: Portadores de Fármacos
Seres Humanos
Instilação de Medicamentos
Otite Externa/metabolismo
Tampões Cirúrgicos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drug Carriers); 0 (Gentamicins); 5E8K9I0O4U (Ciprofloxacin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170712
[St] Status:MEDLINE
[do] DOI:10.1017/S002221511700144X


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[PMID]:28682023
[Au] Autor:Kang YK; Im JC; Shin JP; Kim IT; Park DH
[Ad] Endereço:Department of Ophthalmology, Kyungpook National University School of Medicine, Daegu, Korea.
[Ti] Título:Short-term Analysis of the Residual Volume of an Eye Drop Following 23-Gauge Microincision Vitrectomy Surgery.
[So] Source:Korean J Ophthalmol;31(5):439-445, 2017 Oct.
[Is] ISSN:2092-9382
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To evaluate the change of residual volume of eye drop after instillation in patients with 23-gauge microincision vitrectomy surgery (MIVS). METHODS: Patient who were treated 23-gauge MIVS from November 2014 to July 2015 were included. The residual volume was defined as the amount of remnant eye drop in patient's eyes after instillation, calculated as the difference between instillation volume and spilled volume of eye drop. Calculation of residual volume of eye drop was performed one day before surgery, and daily from postoperative day 1 to day 5. RESULTS: Forty consecutive patients were included. The residual volume of eye drop decreased from 30.3 ± 1.4 µL at baseline to 13.0 ± 1.5 µL at day 1, 18.3 ± 1.6 µL at day 2, 24.7 ± 1.5 µL at day 3, and 27.9 ± 1.4 µL in day 4, postoperatively (p < 0.001, respectively). The volume at postoperative day 5 was 29.4 ± 1.3 µL, but it was not different from the volume at baseline (p = 0.105). The change of residual volume was significantly correlated with postoperative chemosis (r = 0.672, p < 0.001) and effected by the number of quadrant with postoperative chemosis (p < 0.05). CONCLUSIONS: This study shows that postoperative residual volume of eye drop after instillation decreased until postoperative day 4, and postoperative chemosis affects the change of residual volume. Thus, checking proper use of eye drops and teaching about instillation technique by physician is necessary for patients with 23-gauge MIVS.
[Mh] Termos MeSH primário: Ácido Hialurônico/farmacocinética
Microcirurgia/métodos
Doenças Retinianas/cirurgia
Vitrectomia/métodos
[Mh] Termos MeSH secundário: Feminino
Seguimentos
Seres Humanos
Ácido Hialurônico/administração & dosagem
Instilação de Medicamentos
Masculino
Meia-Idade
Soluções Oftálmicas/administração & dosagem
Soluções Oftálmicas/farmacocinética
Período Pós-Operatório
Estudos Prospectivos
Doenças Retinianas/metabolismo
Viscossuplementos/administração & dosagem
Viscossuplementos/farmacocinética
Acuidade Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ophthalmic Solutions); 0 (Viscosupplements); 9004-61-9 (Hyaluronic Acid)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.3341/kjo.2016.0090


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[PMID]:28496043
[Au] Autor:Ema M; Takehara H; Naya M; Kataura H; Fujita K; Honda K
[Ad] Endereço:Research Institute of Science for Safety and Sustainability, National Institute of Advanced Industrial Science and Technology (AIST).
[Ti] Título:Length effects of single-walled carbon nanotubes on pulmonary toxicity after intratracheal instillation in rats.
[So] Source:J Toxicol Sci;42(3):367-378, 2017.
[Is] ISSN:1880-3989
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:We aimed to evaluate the effects of the length of single-walled carbon nanotubes (SWCNTs) on pulmonary toxicity in rats. Each rat received a single intratracheal instillation of short (S-) (average length of 0.40 µm) or long (L-) (average length of 2.77 µm) SWCNTs at a dose of 1 mg/kg and was observed for the next 6 months. Neither S- nor L-SWCNTs affected clinical signs, body weight, or autopsy findings. An increase in lung weight was observed after instillation of S- or L-SWCNTs; however, lung weights were slightly higher in the rats that were administered the S-SWCNTs. Distinct differences in bronchoalveolar lavage fluid (BALF) composition were observed between the S- and L-SWCNT-treated rats as early as 7 days after the intratracheal instillations of the SWCNTs. The S-SWCNTs caused persistent lung injury and inflammation during the 6-month observational period. However, the L-SWCNTs induced minimal lung injury and inflammation. Although the S- and L-SWCNTs changed BALF parameters and histopathological features of the lung, the magnitudes of the changes observed after the S-SWCNT treatment were greater than the respective changes observed after the L-SWCNT treatment. These findings indicate that the severity of the pulmonary toxicity caused after intratracheal instillation of SWCNT depends on the length of the SWCNTs. It appears that shorter SWCNTs induce greater pulmonary toxicity than longer SWCNTs do.
[Mh] Termos MeSH primário: Pulmão/efeitos dos fármacos
Pulmão/patologia
Nanotubos de Carbono/química
Nanotubos de Carbono/toxicidade
[Mh] Termos MeSH secundário: Animais
Relação Dose-Resposta a Droga
Instilação de Medicamentos
Masculino
Tamanho do Órgão/efeitos dos fármacos
Ratos Sprague-Dawley
Fatores de Tempo
Traqueia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nanotubes, Carbon)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170513
[St] Status:MEDLINE
[do] DOI:10.2131/jts.42.367


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[PMID]:28353632
[Au] Autor:Tsukioka T; Takemura S; Minamiyama Y; Mizuguchi S; Toda M; Okada S
[Ad] Endereço:Department of Thoracic Surgery, Osaka City University Graduate School of Medicine, Osaka 5458585, Japan. m1156870@med.osaka-cu.ac.jp.
[Ti] Título:Attenuation of Bleomycin-Induced Pulmonary Fibrosis in Rats with S-Allyl Cysteine.
[So] Source:Molecules;22(4), 2017 Mar 29.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Pulmonary fibrosis is a complex disease with high mortality and morbidity. As there are currently no effective treatments, development of new strategies is essential for improving therapeutic outcomes. -allyl cysteine (SAC) is a constituent of aged garlic extract that has demonstrated efficacy as an antioxidant and anti-inflammatory agent. The current study examines the effects of SAC on pulmonary fibrosis induced by a single intratracheal instillation of bleomycin (2.5 mg/kg). SAC was administered to rats as 0.15% SAC-containing diet from seven days prior to instillation up until the conclusion of the experiment (14 days post-instillation). SAC significantly reduced collagen mRNA expression and protein deposition (33.3 ± 2.7 µg/mg and 28.2 ± 2.1 µg/mg tissue in vehicle- and SAC-treated rats, respectively), and decreased fibrotic area, as assessed histologically. In the rats' lungs, SAC also attenuated the increased expression of transforming growth factor-ß1 (TGF-ß1), a central regulator of myofibroblast recruitment, activation, and differentiation. While bleomycin instillation increased the number of myofibroblasts within the lung mesenchymal area, this change was significantly reduced by SAC treatment. SAC may exert efficacy as an anti-fibrotic by attenuating myofibroblast differentiation through TGF-ß1-mediated fibroproliferative processes. Thus, our results indicate SAC may be useful for the prevention or treatment of pulmonary fibrosis.
[Mh] Termos MeSH primário: Bleomicina/efeitos adversos
Cisteína/análogos & derivados
Miofibroblastos/efeitos dos fármacos
Fibrose Pulmonar/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Diferenciação Celular/efeitos dos fármacos
Colágeno/genética
Colágeno/metabolismo
Cisteína/administração & dosagem
Cisteína/farmacologia
Modelos Animais de Doenças
Regulação da Expressão Gênica/efeitos dos fármacos
Instilação de Medicamentos
Masculino
Miofibroblastos/citologia
Fibrose Pulmonar/induzido quimicamente
Fibrose Pulmonar/metabolismo
Ratos
Fator de Crescimento Transformador beta1/genética
Fator de Crescimento Transformador beta1/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Tgfb1 protein, rat); 0 (Transforming Growth Factor beta1); 11056-06-7 (Bleomycin); 81R3X99M15 (S-allylcysteine); 9007-34-5 (Collagen); K848JZ4886 (Cysteine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170518
[Lr] Data última revisão:
170518
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170330
[St] Status:MEDLINE


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[PMID]:28030981
[Au] Autor:Lingabathula H; Yellu N
[Ad] Endereço:a Department of Pharmacology and Toxicology , University College of Pharmaceutical Sciences, Kakatiya University , Warangal , Telangana , India.
[Ti] Título:Evaluation of oxidative stress induction in rats following exposure to silver nanorods.
[So] Source:Toxicol Mech Methods;27(4):272-278, 2017 May.
[Is] ISSN:1537-6524
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The study investigated the oxidative stress induction by the 10 and 25 nm silver nanorods (SNRs) following intra-tracheal instillation in rats after 1 day, 1 week, 1 month and 3 months post instillation periods at 1 and 5 mg/kg b.w. doses. The blood was withdrawn by retro orbital plexus method after exposure periods and different oxidative stress markers were estimated. The results showed that the both sizes of SNRs induced increased levels of malondialdehyde (MDA) and depleted glutathione (GSH) levels after 1 day and 1 week post exposure periods. The 10 and 25 nm SNRs at both doses displayed that significantly reduced levels of superoxide dismutase (SOD) and catalase following 1 day and 1 week post exposure periods. Also, the results have shown that decrease in total antioxidant capacity (TAC) of both sizes of SNRs significantly following 1 day and 1 week post exposure periods, indicating the oxidative stress induction by SNRs. In spite, there were no significant changes in oxidative stress markers following 1 month and 3 months post exposure periods may be due to recovery. The increased levels of MDA and decreased levels of GSH, SOD, catalase and TAC activity are strongly associated to ROS production and lipid peroxidation, suggesting the induction of oxidative stress in rats. The 10 nm SNRs at 5 mg/kg b.w. dose exposures in rats have shown greater changes in all oxidative stress parameters, indicating the greater induction of oxidative stress when compared with the 25 nm SNRs, representing the size-dose-dependent induction of oxidative stress of SNRs.
[Mh] Termos MeSH primário: Nanotubos/toxicidade
Estresse Oxidativo/efeitos dos fármacos
Prata/toxicidade
[Mh] Termos MeSH secundário: Animais
Antioxidantes/metabolismo
Biomarcadores/metabolismo
Relação Dose-Resposta a Droga
Instilação de Medicamentos
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Malondialdeído/metabolismo
Nanotubos/química
Tamanho da Partícula
Quartzo/química
Quartzo/toxicidade
Ratos Wistar
Prata/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biomarkers); 14808-60-7 (Quartz); 3M4G523W1G (Silver); 4Y8F71G49Q (Malondialdehyde)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161230
[St] Status:MEDLINE
[do] DOI:10.1080/15376516.2016.1274351


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[PMID]:27993944
[Au] Autor:Rumsey WL; Bolognese B; Davis AB; Flamberg PL; Foley JP; Katchur SR; Kotzer CJ; Osborn RR; Podolin PL
[Ad] Endereço:Respiratory Therapeutic Area, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, PO Box 1539, King of Prussia, PA 19406, USA.
[Ti] Título:Effects of airborne toxicants on pulmonary function and mitochondrial DNA damage in rodent lungs.
[So] Source:Mutagenesis;32(3):343-353, 2017 May 01.
[Is] ISSN:1464-3804
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Inhalation of airborne toxicants such as cigarette smoke and ozone is a shared health risk among the world's populations. The use of toxic herbicides like paraquat (PQ) is restricted by many countries, yet in the developing world PQ has demonstrable ill effects. The present study examined changes in pulmonary function, mitochondrial DNA (mtDNA) integrity and markers of DNA repair induced by acute or repeated exposure of PQ to rats. Similar to cigarette smoke and ozone, PQ promotes oxidative stress, and the impact of PQ on mtDNA was compared with that obtained with these agents. Tracheal instillation (i.t.) of PQ (0.01-0.075 mg/kg) dose dependently increased Penh (dyspnoea) by 48 h while body weight and temperature declined. Lung wet weight and the wet/dry weight ratio rose; for the latter, by as much as 52%. At low doses (0.02 and 0.03 mg/kg), PQ increased Penh by about 7.5-fold at 72 h. It quickly waned to near baseline levels. The lung wet/dry weight ratio remained elevated 7 days after administration coincident with marked inflammatory cell infiltrate. Repeated administration of PQ (1 per week for 8 weeks) resulted in a similar rise in Penh on the first instillation, but the magnitude of this response was markedly attenuated upon subsequent exposures. Pulmonary [lactate] and catalase activity, [8-oxodG] and histone fragmentation (cell death) were significantly increased. Repeated PQ instillation downregulated the expression of the mitochondrial-encoded genes, mtATP8, mtNd2 and mtcyB and nuclear ones for the DNA glycosylases, Ogg1, Neil1, Neil2 and Neil3. Ogg1 protein content decreased after acute and repeated PQ administration. mtDNA damage or changes in mtDNA copy number were evident in lungs of PQ-, cigarette smoke- and ozone-exposed animals. Taken together, these data indicate that loss of pulmonary function and inflammation are coupled to the loss of mtDNA integrity and DNA repair capability following exposure to airborne toxicants.
[Mh] Termos MeSH primário: Dano ao DNA
DNA Glicosilases/efeitos dos fármacos
Reparo do DNA/efeitos dos fármacos
DNA Mitocondrial/efeitos dos fármacos
Pulmão/efeitos dos fármacos
Paraquat/toxicidade
[Mh] Termos MeSH secundário: Animais
DNA Glicosilases/genética
DNA Mitocondrial/metabolismo
Desoxiguanosina/análogos & derivados
Regulação para Baixo
Feminino
Herbicidas/administração & dosagem
Herbicidas/farmacologia
Herbicidas/toxicidade
Instilação de Medicamentos
Pulmão/metabolismo
Pulmão/fisiopatologia
Masculino
Camundongos
Estresse Oxidativo
Paraquat/administração & dosagem
Paraquat/farmacologia
Ratos
Traqueia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Mitochondrial); 0 (Herbicides); 88847-89-6 (8-oxo-7-hydrodeoxyguanosine); EC 3.2.2.- (DNA Glycosylases); G9481N71RO (Deoxyguanosine); PLG39H7695 (Paraquat)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161221
[St] Status:MEDLINE
[do] DOI:10.1093/mutage/gew063


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[PMID]:27993589
[Au] Autor:Barnebey HS; Robin AL
[Ad] Endereço:Specialty Eyecare Centre, Bellevue, Washington. Electronic address: hbarnebey@specialtyeyecarecentre.com.
[Ti] Título:Adherence to Fixed-Combination Versus Unfixed Travoprost 0.004%/Timolol 0.5% for Glaucoma or Ocular Hypertension: A Randomized Trial.
[So] Source:Am J Ophthalmol;176:61-69, 2017 Apr.
[Is] ISSN:1879-1891
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To assess adherence to treatment with fixed-combination travoprost 0.004%/timolol 0.5% (TTFC) compared with separate containers of travoprost 0.004% and timolol 0.5% (TRAV+TIM; unfixed) using electronic dosing aids. DESIGN: Randomized, controlled, observer-masked clinical trial. METHODS: setting: Two US clinical sites. PATIENT POPULATION: Eligible patients were adults diagnosed with open-angle glaucoma or ocular hypertension. Patients (n = 81) were sequentially randomized 1:1 to receive TTFC or TRAV+TIM for 12 months. INTERVENTION: TTFC was administered once daily in the morning or evening with a single dosing aid. Patients randomized to TRAV+TIM administered TRAV once daily in the evening and TIM once daily in the morning using separate dosing aids. MAIN OUTCOME MEASURE: Adherence with administered medication, as recorded by the dosing aids. RESULTS: Mean ± SD patient age was 60 ± 10 years; most patients were male and white. Compared with TRAV+TIM (n = 40), patients receiving TTFC (n = 41) were consistently adherent on a greater percentage of days through month 12 (60% vs 43%). At months 1, 3, 6, and 12, 80% adherence was achieved by 71% vs 38%, 53% vs 30%, 45% vs 16%, and 32% vs 11% of patients receiving TTFC vs TRAV+TIM, respectively. Significantly more patients were adherent on ≥80% of days with TTFC compared with TRAV+TIM (P < .001 to P = .041). Both treatments reduced IOP from baseline, and no safety issues were identified in either group. Ocular hyperemia was the most common treatment-related adverse event (n = 3/group). CONCLUSIONS: Patients receiving TTFC maintained better treatment adherence compared with patients receiving TRAV+TIM through 12 months of on-therapy evaluation. This suggests that, for patients requiring multiple IOP-lowering medications, a fixed combination may provide improved long-term adherence compared with unfixed therapy.
[Mh] Termos MeSH primário: Pressão Intraocular/efeitos dos fármacos
Hipertensão Ocular/tratamento farmacológico
Cooperação do Paciente
Timolol/administração & dosagem
Travoprost/administração & dosagem
[Mh] Termos MeSH secundário: Antagonistas Adrenérgicos beta/administração & dosagem
Adulto
Idoso
Idoso de 80 Anos ou mais
Anti-Hipertensivos/administração & dosagem
Relação Dose-Resposta a Droga
Quimioterapia Combinada
Feminino
Seguimentos
Seres Humanos
Instilação de Medicamentos
Masculino
Meia-Idade
Hipertensão Ocular/diagnóstico
Hipertensão Ocular/fisiopatologia
Método Simples-Cego
Fatores de Tempo
Tonometria Ocular
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Adrenergic beta-Antagonists); 0 (Antihypertensive Agents); 817W3C6175 (Timolol); WJ68R08KX9 (Travoprost)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170508
[Lr] Data última revisão:
170508
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161221
[St] Status:MEDLINE


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[PMID]:27690696
[Au] Autor:Atta HM; Al-Hendy AA; Abdel Raheim SR; Abdel-Ghany H; Nasif KA; Abdellah AM; Zenhom NM; Kamel HS
[Ad] Endereço:a Department of Surgery , Faculty of Medicine, Minia University , El-Minia , Egypt.
[Ti] Título:Modified Adenovirus Reduces De Novo Peritoneal Adhesions in Rats and Limits Off-Target Transfection. Role of EZH2 in Adhesion Formation.
[So] Source:J Invest Surg;30(2):78-87, 2017 Apr.
[Is] ISSN:1521-0553
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIM OF THE STUDY: Adenovector encoding tissue plasminogen activator (tPA) was shown to reduce experimental peritoneal adhesion. We investigated the targeting potential of our modified adenovector, its ability to reduce adhesions and the epigenetic role of histone methyltransferase EZH2 in adhesion formation. MATERIALS AND METHODS: Control lacZ, nonmodified tPA or modified tPA vectors were instilled in the peritoneal cavity after injury in de novo adhesions or after lysis of adhesions in recurrent adhesions. Adhesion severity was scored and adhesions and liver tissues were examined for adenovirus E4 gene and tPA mRNA expression. Levels of tPA, plasminogen activator inhibitor-1 (PAI-1), transforming growth factor-ß1 (TGF-ß1), and EZH2 expression were measured. RESULTS: E4 transcripts were detected in adhesions of nonmodified and modified and in livers of nonmodified but not in livers of modified de novo adhesions. Both nonmodified (p = 0.021) and modified vectors (p = 0.036) reduced the severity of de novo adhesions compared to lacZ vector. Levels of tPA in nonmodified (p = 0.021) and modified adhesions (p = 0.001) were elevated while PAI-1 (p = 0.013 and p = 0.001, respectively) and TGF-ß1 levels (p = 0.002 and p = 0.016, respectively) were reduced compared with lacZ group. All vectors were not expressed in recurrent adhesions and severity score were not different among groups. EZH2 levels were elevated in de novo nontreated (p = 0.001) and was further increased in recurrent (p = 0.001) nontreated adhesions compared with noninjured peritoneum. CONCLUSION: Modified adenovirus successfully targeted de novo adhesions but not liver tissues and reduced the severity of de novo adhesions. EZH2 is involved in the development and progression of peritoneal adhesions.
[Mh] Termos MeSH primário: Adenoviridae/genética
Proteína Potenciadora do Homólogo 2 de Zeste/metabolismo
Vetores Genéticos/efeitos adversos
Fígado/patologia
Doenças Peritoneais/metabolismo
Doenças Peritoneais/patologia
Complicações Pós-Operatórias/metabolismo
[Mh] Termos MeSH secundário: Proteínas E4 de Adenovirus/metabolismo
Animais
Procedimentos Cirúrgicos do Sistema Digestório/efeitos adversos
Modelos Animais de Doenças
Proteína Potenciadora do Homólogo 2 de Zeste/genética
Epigênese Genética
Vetores Genéticos/administração & dosagem
Seres Humanos
Instilação de Medicamentos
Masculino
Doenças Peritoneais/etiologia
Inibidor 1 de Ativador de Plasminogênio/metabolismo
Complicações Pós-Operatórias/etiologia
Complicações Pós-Operatórias/patologia
Ratos
Ratos Wistar
Aderências Teciduais/etiologia
Aderências Teciduais/metabolismo
Aderências Teciduais/patologia
Ativador de Plasminogênio Tecidual/genética
Ativador de Plasminogênio Tecidual/metabolismo
Transfecção/instrumentação
Transfecção/métodos
Fator de Crescimento Transformador beta1/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adenovirus E4 Proteins); 0 (Plasminogen Activator Inhibitor 1); 0 (Serpine1 protein, rat); 0 (Transforming Growth Factor beta1); EC 2.1.1.43 (EZH2 protein, rat); EC 2.1.1.43 (Enhancer of Zeste Homolog 2 Protein); EC 3.4.21.68 (Tissue Plasminogen Activator)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161004
[St] Status:MEDLINE
[do] DOI:10.1080/08941939.2016.1229366


  9 / 1372 MEDLINE  
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[PMID]:27623423
[Au] Autor:Mohan A; Tiwari P; Madan K; Hadda V; Poulose R; Bhalla AS; Khandelwal R; Khilnani GC; Guleria R
[Ad] Endereço:Departments of *Pulmonary Medicine and Sleep Disorders †Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India.
[Ti] Título:Intrabronchial Voriconazole is a Safe and Effective Measure for Hemoptysis Control in Pulmonary Aspergilloma.
[So] Source:J Bronchology Interv Pulmonol;24(1):29-34, 2017 Jan.
[Is] ISSN:1948-8270
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Hemoptysis is common in pulmonary aspergilloma. Current treatment modalities such as surgical resection or bronchial artery embolization (BAE) are limited by lack of technical expertise and risk of recurrence, respectively. We describe our experience of treating aspergilloma and hemoptysis with bronchoscopic instillation of voriconazole. METHODS: We retrospectively reviewed records of patients with symptomatic aspergilloma undergoing bronchoscopic voriconazole instillation. Four sessions were carried out at weekly intervals using 400 mg voriconazole dissolved in 20 mL 0.9% normal saline. RESULTS: A total of 82 subjects were evaluated [66 males; mean (SD) age, 43.2 (14.1) y]. The commonest underlying etiology was posttubercular sequelae (95.1%). Of these, 18 patients (22%) had BAE within the last 1 year. The mean (SD) size of aspergilloma was 4.5 cm (1.5 cm). Following voriconazole instillation, 25 patients (30.5%) had significant resolution of hemoptysis after first session, and 52 patients (68.3%) after the second session. Transient postprocedure cough (n=38; 46.3%) was the commonest procedure-related adverse event. Follow-up CT (n=47) showed reduction in aspergilloma size in 54% and no change in 40.4%. The median (IQR) hemoptysis-free period was 12 months (IQR, 9 to 15.5 mo). Recurrence of significant hemoptysis occurred in 24 (29.3%) patients during a median follow-up of 14.5 months (IQR, 9-18 mo). A history of prior BAE and baseline aspergilloma size were significantly associated with recurrence of significant hemoptysis. CONCLUSION: Intrabronchial voriconazole instillation seems to be a safe and effective modality for hemoptysis control in pulmonary aspergilloma.
[Mh] Termos MeSH primário: Broncoscopia/métodos
Hemoptise/tratamento farmacológico
Aspergilose Pulmonar/tratamento farmacológico
Voriconazol/administração & dosagem
[Mh] Termos MeSH secundário: Adulto
Broncoscopia/efeitos adversos
Feminino
Seres Humanos
Instilação de Medicamentos
Masculino
Meia-Idade
Aspergilose Pulmonar/complicações
Estudos Retrospectivos
Resultado do Tratamento
Voriconazol/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
JFU09I87TR (Voriconazole)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170530
[Lr] Data última revisão:
170530
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160914
[St] Status:MEDLINE


  10 / 1372 MEDLINE  
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[PMID]:26148340
[Au] Autor:Pereira IC; Matayoshi S
[Ad] Endereço:a Department of Ophthalmology , University of São Paulo , São Paulo , Brazil.
[Ti] Título:Quantitative Comparison of the Effect of 10% Phenylephrine Instillation and Manual Elevation in Patients with Involutional Blepharoptosis.
[So] Source:Semin Ophthalmol;32(2):172-176, 2017.
[Is] ISSN:1744-5205
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To compare the effect of 10% phenylephrine (PE) instillation and manual elevation (ME) on the upper eyelid position of the tested eye and the contralateral eye in patients with involutional blepharoptosis (IB). METHODS: IB patients were submitted to two tests followed by observation of the effect on the contralateral eyelid: (1) ME of the more ptotic eyelid; and (2) instillation of two drops of 10% PE (phenylephrine test) in the more ptotic eye. The patients were filmed before and 5, 10, and 15 minutes after instillation. The upper eyelid margin reflex distance (MRD1) was measured using the software Image J, and the results were analyzed with the linear mixed-effects model. RESULTS: The study included 70 patients aged 44-86 years, 64 of whom were female (91.43%), divided into three groups: subjects with unilateral IB, subjects with bilateral IB, and controls. The eye submitted to instillation with 10% PE displayed significant elevation during the first 10 min: from 1.33 ± 0.66 mm to 2.06 ± 0.89 mm (unilateral group), from 1.26 ± 0.63 mm to 2.29 ± 0.86 mm (bilateral group), and from 3.12 ± 0.68 mm to 4.06 ± 0.92 mm (control group). MRD1 decreased in the contralateral eye in IB patients, significantly more so after the phenylephrine test: PE vs. ME = 18.9% versus 17.2% reduction in the unilateral group, and 13.6% versus 10.7% reduction in the bilateral group. The outcome was not influenced by IB severity and the concurrence of IB and eye dominance. CONCLUSION: Both ME and 10% PE affected the contralateral upper eyelid, but the response was significantly better with the latter.
[Mh] Termos MeSH primário: Blefaroptose/terapia
Pálpebras
Fenilefrina/administração & dosagem
[Mh] Termos MeSH secundário: Agonistas de Receptores Adrenérgicos alfa 1/administração & dosagem
Adulto
Idoso
Idoso de 80 Anos ou mais
Relação Dose-Resposta a Droga
Feminino
Seguimentos
Seres Humanos
Instilação de Medicamentos
Masculino
Meia-Idade
Soluções Oftálmicas/administração & dosagem
Estudos Retrospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenergic alpha-1 Receptor Agonists); 0 (Ophthalmic Solutions); 1WS297W6MV (Phenylephrine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150707
[St] Status:MEDLINE
[do] DOI:10.3109/08820538.2015.1045152



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