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[PMID]:29466163
[Au] Autor:Lembke A; Papac J; Humphreys K
[Ad] Endereço:From the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford (A.L., J.P., K.H.), and the Veterans Affairs Palo Alto Health Care System (K.H.) - both in California.
[Ti] Título:Our Other Prescription Drug Problem.
[So] Source:N Engl J Med;378(8):693-695, 2018 Feb 22.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Benzodiazepinas/uso terapêutico
Uso Excessivo de Produtos e Serviços de Saúde/tendências
Uso Indevido de Medicamentos sob Prescrição/tendências
Transtornos Relacionados ao Uso de Substâncias
[Mh] Termos MeSH secundário: Seres Humanos
Uso Excessivo de Produtos e Serviços de Saúde/prevenção & controle
Transtornos Relacionados ao Uso de Substâncias/mortalidade
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
12794-10-4 (Benzodiazepines)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180222
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMp1715050


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[PMID]:29183062
[Au] Autor:Rudman W; Corcoran P; Elliott K
[Ad] Endereço:University of Aberdeen, Aberdeen, Scotland.
[Ti] Título:Prescription Drug Monitoring Programs and Opioid Death Rates.
[So] Source:JAMA;318(20):2044, 2017 11 28.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Analgésicos Opioides
Programas de Monitoramento de Prescrição de Medicamentos
[Mh] Termos MeSH secundário: Monitoramento de Medicamentos
Seres Humanos
Uso Indevido de Medicamentos sob Prescrição
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
0 (Analgesics, Opioid)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.16300


  3 / 1114 MEDLINE  
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[PMID]:29369866
[Au] Autor:Guy GP; Shults RA
[Ad] Endereço:Gery P. Guy Jr. is a health economist in the Division of Unintentional Injury Prevention, National Center for Injury Prevention and Control, at the Centers for Disease Control and Prevention in Atlanta, where Ruth A. Shults is an epidemiologist. Contact author: Gery P. Guy Jr., irm2@cdc.gov. The authors have disclosed no potential conflicts of interest, financial or otherwise. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.
[Ti] Título:Opioid Prescribing in the United States.
[So] Source:Am J Nurs;118(2):19-20, 2018 Feb.
[Is] ISSN:1538-7488
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Evidence-based information for nurses on the risks and benefits of prescription opioids.
[Mh] Termos MeSH primário: Analgésicos Opioides/efeitos adversos
Prescrições de Medicamentos/estatística & dados numéricos
Uso Indevido de Medicamentos sob Prescrição/prevenção & controle
[Mh] Termos MeSH secundário: Centers for Disease Control and Prevention (U.S.)
Seres Humanos
Transtornos Relacionados ao Uso de Opioides/epidemiologia
Padrões de Prática Médica
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Opioid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM; N
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.1097/01.NAJ.0000530238.99144.e8


  4 / 1114 MEDLINE  
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Registro de Ensaios Clínicos
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[PMID]:29198186
[Au] Autor:Brown R; Deyo B; Riley C; Quanbeck A; Glass JE; Turpin R; Hetzel S; Nicholas C; Cruz M; Agarwal S
[Ad] Endereço:Department of Family Medicine and Community Health, University of Wisconsin, 1100 Delaplaine Ct, Madison, WI, 53715, USA. Randy.Brown@fammed.wisc.edu.
[Ti] Título:Screening in Trauma for Opioid Misuse Prevention (STOMP): study protocol for the development of an opioid risk screening tool for victims of injury.
[So] Source:Addict Sci Clin Pract;12(1):28, 2017 Dec 04.
[Is] ISSN:1940-0640
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Opioid addiction and overdose are epidemic in the U.S. Victims of traumatic injury are at greater than average risk for opioid misuse and related complications. Potential risk screens and preventive interventions in this clinical population remain under-investigated. The current project seeks to develop and pilot the implementation of a screening tool for opioid risk at American College of Surgeons (ACS) Level I and Level II trauma centers. METHODS: The project began with an online survey, which was sent to Wisconsin trauma center medical directors and trauma coordinators for the purpose of gathering information on current substance use screening practices. Next, a focus group of trauma center staff was convened to discuss barriers and facilitators to screening, resources available and needed to support trauma patients with opioid use disorders, and measurable clinical observations that could indicate a patient's potential risk for opioid misuse. Data from the surveys and focus group were combined to inform the data collection instruments that are currently being administered to patients recruited from the University of Wisconsin Hospital Trauma Inpatient and Orthopedic Surgery Services. Eligible and consenting patients complete standardized measures of socio-demographics, substance use history, opioid misuse risk, mental health, medical history, and injury and pain severity. Follow up visits at weeks 4, 12, and 24 after hospital discharge assess hypothesized risk factors for opioid addiction and opioid use disorder diagnosis. At the completion of patient data collection, a forward stepwise regression will identify factors of most significant risk of the development of opioid use disorder after traumatic injury. This modeling will inform the development of a novel opioid risk screening tool, which will undergo pilot implementation at 4 Wisconsin ACS Level I and Level II trauma centers, using an evidence-based implementation strategy with roots in systems engineering. DISCUSSION: Positive findings from the proposed work would lead to improved, standardized opioid risk screening practices among victims of traumatic injury. The ultimate goal of this and future work is to reduce the likelihood of opioid misuse, addiction, and related complications, such as overdose and death. Trial registration Clinicaltrials.gov registration number: NCT02861976. Date of registration: Feb 9, 2016.
[Mh] Termos MeSH primário: Analgésicos Opioides/efeitos adversos
Transtornos Relacionados ao Uso de Opioides/diagnóstico
Detecção do Abuso de Substâncias/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Masculino
Saúde Mental
Meia-Idade
Manejo da Dor/métodos
Uso Indevido de Medicamentos sob Prescrição/prevenção & controle
Medição de Risco/métodos
Inquéritos e Questionários
Ferimentos e Lesões/dietoterapia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Opioid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1186/s13722-017-0097-6


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[PMID]:29210868
[Au] Autor:Chiappini S; Schifano F
[Ti] Título:Is There a Potential of Misuse for Quetiapine?: Literature Review and Analysis of the European Medicines Agency/European Medicines Agency Adverse Drug Reactions' Database.
[So] Source:J Clin Psychopharmacol;38(1):72-79, 2018 Feb.
[Is] ISSN:1533-712X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE/BACKGROUND: A recent years' increase in both prescribing and availability of second-generation antipsychotics (SGAs) has been observed. According to the literature, typically made up by case studies/series, quetiapine seems to be the most commonly misused SGA, with both intranasal and intravenous intake modalities having been described. Another SGA that has been anecdotally reported to be misused is olanzapine. For these molecules, both a previous history of drug misuse and being an inmate have been described as factors associated with misuse. Hence, while providing here an updated literature review of the topic, we aimed at assessing all cases of quetiapine misuse/abuse/dependence/withdrawal as reported to the European Medicines Agency's EudraVigilance (EV) database; this was carried out in comparison with the reference drug olanzapine. METHODS: All spontaneous, European Medicines Agency database reports relating to both quetiapine (2005-2016) and olanzapine (2004-2016) misuse/abuse/dependence/withdrawal issues were retrieved, and a descriptive analysis was performed. RESULTS: From the EV database, 18,112 (8.64% of 209,571) and 4178 (7.58% of 55,100) adverse drug reaction reports of misuse/abuse/dependence/withdrawal were associated with quetiapine and olanzapine, respectively. The resulting proportional reporting ratio values suggested that the misuse/abuse-, dependence-, and withdrawal-related adverse drug reactions were more frequently reported for quetiapine (1.07, 1.01, and 5.25, respectively) in comparison with olanzapine. CONCLUSIONS: Despite data collection limitations, present EV data may suggest that, at least in comparison with olanzapine, quetiapine misuse may be a cause for concern.
[Mh] Termos MeSH primário: Antipsicóticos/efeitos adversos
Uso Indevido de Medicamentos sob Prescrição/estatística & dados numéricos
Fumarato de Quetiapina/efeitos adversos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Sistemas de Notificação de Reações Adversas a Medicamentos/estatística & dados numéricos
Antipsicóticos/administração & dosagem
Benzodiazepinas/administração & dosagem
Benzodiazepinas/efeitos adversos
Criança
Bases de Dados Factuais/estatística & dados numéricos
União Europeia
Feminino
Seres Humanos
Masculino
Meia-Idade
Fumarato de Quetiapina/administração & dosagem
Síndrome de Abstinência a Substâncias/epidemiologia
Transtornos Relacionados ao Uso de Substâncias/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antipsychotic Agents); 12794-10-4 (Benzodiazepines); 2S3PL1B6UJ (Quetiapine Fumarate); N7U69T4SZR (olanzapine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE
[do] DOI:10.1097/JCP.0000000000000814


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[PMID]:27776247
[Au] Autor:Karakula SL; Weiss RD; Griffin ML; Borges AM; Bailey AJ; McHugh RK
[Ad] Endereço:Division of Alcohol and Drug Abuse, McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States. Electronic address: skarakula@harvard.mclean.edu.
[Ti] Título:Delay discounting in opioid use disorder: Differences between heroin and prescription opioid users.
[So] Source:Drug Alcohol Depend;169:68-72, 2016 12 01.
[Is] ISSN:1879-0046
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Among those with opioid use disorder, heroin use is associated with poorer prognosis relative to use of prescription opioids alone. However, relatively little is known about distinguishing features between those who use heroin relative to those who use prescription opioids. In the present study we evaluated differences in delay discounting in those with opioid use disorder based on primary opioid of use. Delay discounting is associated with a range of negative outcomes and is an important therapeutic target in this population. METHODS: Treatment-seeking adults with opioid dependence completed self-report measures including past-month opioid use and the Monetary Choice Questionnaire (Kirby and Marakovic, 1996; Kirby et al., 1999), a measure of delay discounting. Participants were divided into two groups based on whether they used any heroin in the past 30days or only prescription opioids, and delay discounting scores were compared between the groups. Group differences in sociodemographic or clinical variables were included in the analysis as covariates. RESULTS: Results from a forward stepwise linear regression indicated that heroin use was associated with significantly higher delay discounting (B=-0.99, SE =0.34, t=-2.88, p=0.005), even when considering covariates. CONCLUSIONS: Adults with opioid dependence who exclusively used prescription opioids had lower delay discounting relative to those who used heroin. This finding contributes further to the literature suggesting that heroin use is associated with greater clinical severity among those with opioid use disorder.
[Mh] Termos MeSH primário: Analgésicos Opioides/efeitos adversos
Desvalorização pelo Atraso
Heroína/efeitos adversos
Transtornos Relacionados ao Uso de Opioides/psicologia
Uso Indevido de Medicamentos sob Prescrição/psicologia
[Mh] Termos MeSH secundário: Adulto
Estudos Transversais
Desvalorização pelo Atraso/efeitos dos fármacos
Desvalorização pelo Atraso/fisiologia
Feminino
Dependência de Heroína/diagnóstico
Dependência de Heroína/psicologia
Seres Humanos
Masculino
Meia-Idade
Transtornos Relacionados ao Uso de Opioides/diagnóstico
Uso Indevido de Medicamentos sob Prescrição/efeitos adversos
Autorrelato
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Analgesics, Opioid); 70D95007SX (Heroin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  7 / 1114 MEDLINE  
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[PMID]:29214309
[Au] Autor:Abbasi J
[Ti] Título:Emergency Department Opioid Misuse Diagnoses Increasing in Adolescents and Young Adults.
[So] Source:JAMA;318(24):2416-2417, 2017 Dec 26.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Analgésicos Opioides
Transtornos Relacionados ao Uso de Opioides/epidemiologia
Uso Indevido de Medicamentos sob Prescrição/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adolescente
Serviço Hospitalar de Emergência
Seres Humanos
Uso Indevido de Medicamentos sob Prescrição/tendências
Estados Unidos/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Opioid)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.16586


  8 / 1114 MEDLINE  
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[PMID]:28742770
[Au] Autor:Vetter TR; Kain ZN
[Ad] Endereço:From the *Department of Surgery and Perioperative Care, Dell Medical School at the University of Texas at Austin, Austin, Texas; and †Center for Stress & Health, University of California, Irvine, Irvine, California.
[Ti] Título:Role of the Perioperative Surgical Home in Optimizing the Perioperative Use of Opioids.
[So] Source:Anesth Analg;125(5):1653-1657, 2017 11.
[Is] ISSN:1526-7598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Several federal agencies have recently noted that the United States is in the midst of an unprecedented "opioid epidemic," with an increasing number of opioid-related overdoses and deaths. Providers currently face 3 population-level, public health challenges in providing optimal perioperative pain care: (1) the continued lack of overall improvement in the excessive incidence of inadequately treated postoperative pain, (2) minimizing or preventing postoperative opioid-related side effects, and (3) addressing current opioid prescribing patterns, and the accompanying problematic surge in prescription opioid diversion, misuse, abuse, addiction, and overdose. In the Perioperative Surgical Home model, anesthesiologists and other pain medicine specialists are uniquely qualified and positioned to develop, implement, and coordinate a comprehensive perioperative analgesic plan, which begins with the formal preoperative patient assessment and continues throughout the postdischarge, convalescence period. The scope and practice of pain management within the Perioperative Surgical Home should thus (a) expand to include routine preoperative patient-level pain-risk stratification (including the chronic use of opioid and nonopioid analgesics), (b) address the multitude of biopsychosocial factors that contribute to interpatient pain variability, and (c) extend and be well coordinated across all 4 phases of the surgical pain experience (preoperative, intraoperative, postoperative, and postdischarge). Specifically, safe and effective perioperative pain management should include a plan of care that is tailored to the individual patient's underlying disease(s), presence of a chronic pain condition and preoperative use of opioids, and the specific surgical procedure-with evidence-based, multimodal analgesic regimens being applied in the vast majority of cases. An iteratively evolutionary component of an existing institutional Perioperative Surgical Home program can be an integrated Transitional Pain Service, which is modeled directly after the well-established prototype at the Toronto General Hospital in Ontario, Canada. This multidisciplinary, perioperative Transitional Pain Service seeks to modify the pain trajectories of patients who are at increased risk of (a) long-term, increasing, excessive opioid consumption and/or (b) developing chronic postsurgical pain. Like the Perioperative Surgical Home program in which it can be logically integrated, such a Transitional Pain Service can serve as the needed but missing linkage to improve the continuum of care and perioperative pain management for elective, urgent, and emergent surgery. Even if successfully and cost-efficiently embedded within an existing Perioperative Surgical Home, a new perioperative Transitional Pain Service will require additional resources.
[Mh] Termos MeSH primário: Analgésicos Opioides/administração & dosagem
Prestação Integrada de Cuidados de Saúde/normas
Transtornos Relacionados ao Uso de Opioides/prevenção & controle
Dor Pós-Operatória/prevenção & controle
Assistência Centrada no Paciente/organização & administração
Uso Indevido de Medicamentos sob Prescrição/prevenção & controle
[Mh] Termos MeSH secundário: Analgésicos Opioides/efeitos adversos
Terapia Combinada
Esquema de Medicação
Prescrições de Medicamentos/normas
Seres Humanos
Transtornos Relacionados ao Uso de Opioides/diagnóstico
Transtornos Relacionados ao Uso de Opioides/epidemiologia
Dor Pós-Operatória/diagnóstico
Dor Pós-Operatória/epidemiologia
Equipe de Assistência ao Paciente/normas
Seleção de Pacientes
Assistência Perioperatória/normas
Padrões de Prática Médica/normas
Medição de Risco
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Analgesics, Opioid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1213/ANE.0000000000002280


  9 / 1114 MEDLINE  
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[PMID]:28456473
[Au] Autor:Deren S; Naegle M; Hagan H; Ompad DC
[Ti] Título:Continuing Links Between Substance Use and HIV Highlight the Importance of Nursing Roles.
[So] Source:J Assoc Nurses AIDS Care;28(4):622-632, 2017 Jul - Aug.
[Is] ISSN:1552-6917
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Links between HIV and substance use were identified early in the U.S. HIV epidemic. People who use drugs are at risk of HIV infection through shared injection equipment and risky sexual behaviors. In addition, substance use has negative health consequences for people living with HIV. The prescription opioid misuse epidemic, linked to injection drug use, hepatitis C infection, and HIV, poses a new threat to declining HIV rates. We reviewed evidence-based interventions that decrease HIV risk in people who use drugs (needle/syringe programs, medication-assisted treatment, engagement in HIV care, and preexposure prophylaxis/postexposure prophylaxis). The critical roles of nurses in HIV prevention/care for this population are described, including applying the principles of harm reduction, screening for substance use, and undertaking implementation and research efforts. As the nation's largest health care profession, nurses are positioned to contribute to the quality of HIV-related prevention/care for people who use drugs and to lead practice initiatives.
[Mh] Termos MeSH primário: Medicina Baseada em Evidências
Infecções por HIV/prevenção & controle
Uso Comum de Agulhas e Seringas/efeitos adversos
Papel do Profissional de Enfermagem
Transtornos Relacionados ao Uso de Opioides/psicologia
Abuso de Substâncias por Via Intravenosa/psicologia
[Mh] Termos MeSH secundário: Adulto
Redução do Dano
Seres Humanos
Programas de Troca de Agulhas
Uso Indevido de Medicamentos sob Prescrição
Assunção de Riscos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171214
[Lr] Data última revisão:
171214
[Sb] Subgrupo de revista:IM; N; X
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


  10 / 1114 MEDLINE  
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[PMID]:29196326
[Au] Autor:Keith DA; Kulich RJ; Bharel M; Boose RE; Brownstein J; Da Silva JD; D'Innocenzo R; Donoff RB; Factor E; Hutter JW; Shaefer JR; Karimbux NY; Jack H; Thomas HF
[Ad] Endereço:Dr. Keith is Professor of Oral and Maxillofacial Surgery, Harvard School of Dental Medicine and Visiting Oral and Maxillofacial Surgeon, Massachusetts General Hospital; Dr. Kulich is Professor, Tufts University School of Dental Medicine and the Pain Center, Massachusetts General Hospital; Dr. Bharel
[Ti] Título:Massachusetts Dental Schools Respond to the Prescription Opioid Crisis: A Statewide Collaboration.
[So] Source:J Dent Educ;81(12):1388-1394, 2017 Dec.
[Is] ISSN:1930-7837
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The prescription opioid crisis has involved all sectors of U.S. society, affecting every community, socioeconomic group, and age group. While federal and state agencies are actively working to deal with the epidemic, medical and dental providers have been tasked to increase their awareness of the issues and consider ways to safely prescribe opioids and, at the same time, effectively treat their patients' pain. The Commonwealth of Massachusetts, under the leadership of Governor Charles D. Baker and his administration, challenged the state's four medical schools and three dental schools to improve their curricula to prepare the next generation of clinicians to deal with this crisis in an evidence-based, effective, and sympathetic way. This Perspectives article outlines the national prescription opioid crisis, details its effects in Massachusetts, and describes the interdisciplinary collaboration among the Commonwealth, the three dental schools, the Massachusetts Dental Society, and a concerned student group. The article also describes the efforts each dental school is undertaking as well as an assessment of the challenges and limitations in implementing the initiative. The authors hope that the Massachusetts model will be a useful resource for dental schools in other states.
[Mh] Termos MeSH primário: Analgésicos Opioides/uso terapêutico
Transtornos Relacionados ao Uso de Opioides/prevenção & controle
Uso Indevido de Medicamentos sob Prescrição/prevenção & controle
Faculdades de Odontologia
[Mh] Termos MeSH secundário: Analgésicos Opioides/efeitos adversos
Currículo
Educação em Odontologia
Seres Humanos
Comunicação Interdisciplinar
Relações Interinstitucionais
Massachusetts
Faculdades de Odontologia/organização & administração
Sociedades Odontológicas/organização & administração
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Opioid)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171211
[Lr] Data última revisão:
171211
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:171203
[St] Status:MEDLINE
[do] DOI:10.21815/JDE.017.098



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