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[PMID]:28922358
[Au] Autor:Yonucu S; Yιlmaz D; Phipps C; Unlu MB; Kohandel M
[Ad] Endereço:Department of Physics, Bogazici University, Bebek, Istanbul, Turkey.
[Ti] Título:Quantifying the effects of antiangiogenic and chemotherapy drug combinations on drug delivery and treatment efficacy.
[So] Source:PLoS Comput Biol;13(9):e1005724, 2017 Sep.
[Is] ISSN:1553-7358
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tumor-induced angiogenesis leads to the development of leaky tumor vessels devoid of structural and morphological integrity. Due to angiogenesis, elevated interstitial fluid pressure (IFP) and low blood perfusion emerge as common properties of the tumor microenvironment that act as barriers for drug delivery. In order to overcome these barriers, normalization of vasculature is considered to be a viable option. However, insight is needed into the phenomenon of normalization and in which conditions it can realize its promise. In order to explore the effect of microenvironmental conditions and drug scheduling on normalization benefit, we build a mathematical model that incorporates tumor growth, angiogenesis and IFP. We administer various theoretical combinations of antiangiogenic agents and cytotoxic nanoparticles through heterogeneous vasculature that displays a similar morphology to tumor vasculature. We observe differences in drug extravasation that depend on the scheduling of combined therapy; for concurrent therapy, total drug extravasation is increased but in adjuvant therapy, drugs can penetrate into deeper regions of tumor.
[Mh] Termos MeSH primário: Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem
Quimioterapia Assistida por Computador/métodos
Modelos Biológicos
Neoplasias/tratamento farmacológico
Neoplasias/fisiopatologia
Neovascularização Patológica/tratamento farmacológico
Neovascularização Patológica/fisiopatologia
[Mh] Termos MeSH secundário: Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia
Simulação por Computador
Relação Dose-Resposta a Droga
Seres Humanos
Neoplasias/patologia
Neovascularização Patológica/patologia
Resultado do Tratamento
Carga Tumoral/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pcbi.1005724


  2 / 1590 MEDLINE  
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[PMID]:28552935
[Au] Autor:Maronski R
[Ad] Endereço:Warsaw University of Technology, Institute of Aeronautics and Applied Mechanics, Warsaw, Poland.
[Ti] Título:Optimal strategy in chemotherapy for Malthusian model of cancer growth.
[So] Source:Acta Bioeng Biomech;19(1):63-68, 2017.
[Is] ISSN:1509-409X
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The problem of optimal strategy in cancer chemotherapy is reconsidered. Two incompatible goals should be completed: the number of cancer cells in the patient's body should be reduced and the toxic effect of the therapy should be minimized. Such problem may be formulated in optimal control. The control function is the amount of the drug administered in the time unit. METHODS: The Malthusian model of cell population growth is employed where the rate of increase of the number of cancer cells is proportional to the number of cells in population and an intrinsic rate that usually is assumed to be constant. The performance index is the amount of the drug cumulated in the patient's body and it is minimized. A non-standard method of optimal control is used - method of Miele. RESULTS: The optimal solutions are obtained for three cases: constant intrinsic rate, monotonically increasing/decreasing intrinsic rate and for periodic intrinsic rate. The optimal control is ununique for the first case - the result is irrespective of the strategy. Such result has been known earlier. The optimal control is unique for other cases and it is of bang-bang type. CONCLUSIONS: The ununique solution for constant intrinsic rate is surprising, therefore a mechanical analogy is given. The optimal strategy is in accordance with clinical experience for decreasing intrinsic rate. The optimal control is a periodic function of time for the intrinsic rate of sin/cos type - the drug should be administered, as its value is relatively high.
[Mh] Termos MeSH primário: Antineoplásicos/administração & dosagem
Proliferação Celular/efeitos dos fármacos
Quimioterapia Assistida por Computador/métodos
Modelos Biológicos
Neoplasias/tratamento farmacológico
Neoplasias/patologia
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Simulação por Computador
Relação Dose-Resposta a Droga
Seres Humanos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170530
[St] Status:MEDLINE


  3 / 1590 MEDLINE  
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[PMID]:28541188
[Au] Autor:Xie J; Wang Q
[Ti] Título:A Variable State Dimension Approach to Meal Detection and Meal Size Estimation: In Silico Evaluation Through Basal-Bolus Insulin Therapy for Type 1 Diabetes.
[So] Source:IEEE Trans Biomed Eng;64(6):1249-1260, 2017 Jun.
[Is] ISSN:1558-2531
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: This paper aims to develop an algorithm that can detect unannounced meals and estimate meal sizes to achieve a robust glucose control. METHODS: A variable state dimension (VSD) algorithm is developed to detect unannounced meals and estimate meal sizes, where a Kalman filter operates on a quiescent state model when no meal is detected, and switches to a maneuvering state model to estimate meal information once the meal-induced glucose variability is statistically significant. RESULTS: Through evaluation using 30 subjects of the UVa/Padova simulator, a basal-bolus (BB) control using the VSD-estimated meal size for each meal can achieve mean blood glucose (BG) of 142 mg/dl with an average 17.7% of time in hypoglycemia. In terms of 20 Monte-Carlo simulations for each subject over a two-day scenario, where each meal/snack has a probability of 0.5 not to be announced, the BB control using VSD for unannounced meals can achieve an average mean BG of 143 mg/dl with 8% of time in hypoglycemia, in contrast to mean BG of 180 mg/dl with 8% of time in hypoglycemia obtained by BB with missing boluses. Additionally, VSD is able to detect a meal within 45 (±14) min since its start with a 76% success rate and 16% false alarm rate. CONCLUSION: The addition of VSD to the BB control improves glucose control when meal announcements are missed. SIGNIFICANCE: The VSD can be used as a complementary tool to detect meal and estimate meal size in absence of a meal announcement.
[Mh] Termos MeSH primário: Glicemia/metabolismo
Diabetes Mellitus Tipo 1/tratamento farmacológico
Diabetes Mellitus Tipo 1/fisiopatologia
Quimioterapia Assistida por Computador/métodos
Insulina/administração & dosagem
Refeições/classificação
Modelos Biológicos
[Mh] Termos MeSH secundário: Algoritmos
Simulação por Computador
Retroalimentação Fisiológica
Comportamento Alimentar
Análise de Alimentos/métodos
Seres Humanos
Hipoglicemiantes/administração & dosagem
Período Pós-Prandial
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Hypoglycemic Agents); 0 (Insulin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1109/TBME.2016.2599073


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[PMID]:28507230
[Au] Autor:Christodoulides P; Hirata Y; Domínguez-Hüttinger E; Danby SG; Cork MJ; Williams HC; Aihara K; Tanaka RJ
[Ad] Endereço:Department of Bioengineering, Imperial College London, London SW7 2AZ, UK.
[Ti] Título:Computational design of treatment strategies for proactive therapy on atopic dermatitis using optimal control theory.
[So] Source:Philos Trans A Math Phys Eng Sci;375(2096), 2017 Jun 28.
[Is] ISSN:1364-503X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Atopic dermatitis (AD) is a common chronic skin disease characterized by recurrent skin inflammation and a weak skin barrier, and is known to be a precursor to other allergic diseases such as asthma. AD affects up to 25% of children worldwide and the incidence continues to rise. There is still uncertainty about the optimal treatment strategy in terms of choice of treatment, potency, duration and frequency. This study aims to develop a computational method to design optimal treatment strategies for the clinically recommended 'proactive therapy' for AD. Proactive therapy aims to prevent recurrent flares once the disease has been brought under initial control. Typically, this is done by using an anti-inflammatory treatment such as a potent topical corticosteroid intensively for a few weeks to 'get control', followed by intermittent weekly treatment to suppress subclinical inflammation to 'keep control'. Using a hybrid mathematical model of AD pathogenesis that we recently proposed, we computationally derived the optimal treatment strategies for individual virtual patient cohorts, by recursively solving optimal control problems using a differential evolution algorithm. Our simulation results suggest that such an approach can inform the design of optimal individualized treatment schedules that include application of topical corticosteroids and emollients, based on the disease status of patients observed on their weekly hospital visits. We demonstrate the potential and the gaps of our approach to be applied to clinical settings.This article is part of the themed issue 'Mathematical methods in medicine: neuroscience, cardiology and pathology'.
[Mh] Termos MeSH primário: Anti-Inflamatórios/administração & dosagem
Dermatite Atópica/diagnóstico por imagem
Dermatite Atópica/fisiopatologia
Quimioterapia Assistida por Computador/métodos
Modelos Biológicos
Pele/fisiopatologia
[Mh] Termos MeSH secundário: Administração Cutânea
Algoritmos
Simulação por Computador
Dermatite Atópica/patologia
Fármacos Dermatológicos/administração & dosagem
Relação Dose-Resposta a Droga
Esquema de Medicação
Monitoramento de Medicamentos/métodos
Seres Humanos
Pele/efeitos dos fármacos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Dermatologic Agents)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170517
[St] Status:MEDLINE


  5 / 1590 MEDLINE  
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[PMID]:28368937
[Au] Autor:Marques NR; Whitehead WE; Kallu UR; Kinsky MP; Funston JS; Wassar T; Khan MN; Milosch M; Jupiter D; Grigoriadis K; Kramer GC
[Ad] Endereço:From the *Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas; †Department of Mechanical Engineering, University of Houston, Houston, Texas; and ‡Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, Texas.
[Ti] Título:Physician-Directed Versus Computerized Closed-Loop Control of Blood Pressure Using Phenylephrine in a Swine Model.
[So] Source:Anesth Analg;125(1):110-116, 2017 Jul.
[Is] ISSN:1526-7598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Vasopressors provide a rapid and effective approach to correct hypotension in the perioperative setting. Our group developed a closed-loop control (CLC) system that titrates phenylephrine (PHP) based on the mean arterial pressure (MAP) during general anesthesia. As a means of evaluating system competence, we compared the performance of the automated CLC with physicians. We hypothesized that our CLC algorithm more effectively maintains blood pressure at a specified target with less blood pressure variability and reduces the dose of PHP required. METHODS: In a crossover study design, 6 swine under general anesthesia were subjected to a normovolemic hypotensive challenge induced by sodium nitroprusside. The physicians (MD) manually changed the PHP infusion rate, and the CLC system performed this task autonomously, adjusted every 3 seconds to achieve a predetermined MAP. RESULTS: The CLC maintained MAP within 5 mm Hg of the target for (mean ± standard deviation) 93.5% ± 3.9% of the time versus 72.4% ± 26.8% for the MD treatment (P = .054). The mean (standard deviation) percentage of time that the CLC and MD interventions were above target range was 2.1% ± 3.3% and 25.8% ± 27.4% (P = .06), respectively. Control statistics, performance error, median performance error, and median absolute performance error were not different between CLC and MD interventions. PHP infusion rate adjustments by the physician were performed 12 to 80 times in individual studies over a 60-minute period. The total dose of PHP used was not different between the 2 interventions. CONCLUSIONS: The CLC system performed as well as an anesthesiologist totally focused on MAP control by infusing PHP. Computerized CLC infusion of PHP provided tight blood pressure control under conditions of experimental vasodilation.
[Mh] Termos MeSH primário: Anestesia com Circuito Fechado/métodos
Pressão Sanguínea/efeitos dos fármacos
Quimioterapia Assistida por Computador
Fenilefrina/administração & dosagem
Vasoconstritores/administração & dosagem
[Mh] Termos MeSH secundário: Algoritmos
Anestesia Geral
Anestesiologia
Animais
Automação
Computadores
Estudos Cross-Over
Seres Humanos
Hipotensão/tratamento farmacológico
Monitorização Fisiológica
Nitroprussiato/administração & dosagem
Médicos
Reprodutibilidade dos Testes
Suínos
Vasodilatação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Vasoconstrictor Agents); 169D1260KM (Nitroprusside); 1WS297W6MV (Phenylephrine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE
[do] DOI:10.1213/ANE.0000000000001961


  6 / 1590 MEDLINE  
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[PMID]:28368936
[Au] Autor:Ngan Kee WD; Tam YH; Khaw KS; Ng FF; Lee SWY
[Ad] Endereço:From the *Department of Anaesthesia and Intensive Care, the Chinese University of Hong Kong, China; and †Department of Health Technology and Informatics, the Hong Kong Polytechnic University, Hung Hom, Hong Kong.
[Ti] Título:Closed-Loop Feedback Computer-Controlled Phenylephrine for Maintenance of Blood Pressure During Spinal Anesthesia for Cesarean Delivery: A Randomized Trial Comparing Automated Boluses Versus Infusion.
[So] Source:Anesth Analg;125(1):117-123, 2017 Jul.
[Is] ISSN:1526-7598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We previously described the use of closed-loop feedback computer-controlled infusion of phenylephrine for maintaining blood pressure (BP) during spinal anesthesia for cesarean delivery. In this study, we report a modified system in which phenylephrine is delivered by intermittent boluses rather than infusion. We hypothesized that the use of computer-controlled boluses would result in more precise control of BP compared with infusions. METHODS: Two hundred fourteen healthy patients having spinal anesthesia for elective cesarean delivery were randomized to have their systolic BP maintained by phenylephrine administered by computer-controlled continuous infusion or computer-controlled intermittent boluses. From induction of anesthesia until the time of uterine incision, a noninvasive BP monitor was set to cycle at 1-minute intervals. In the infusion group, the infusion rate was automatically adjusted after each BP measurement using a previously described algorithm. In the bolus group, the algorithm was modified so that the mass of drug that would have been delivered over 1 minute was instead injected as a rapid intravenous bolus after each BP measurement. The precision of BP control was assessed using performance error calculations and compared between groups, with the primary outcome defined as median absolute performance error, and the latter being a measure of inaccuracy showing an average of the magnitudes of the differences of measured BP values above or below the target values. RESULTS: The precision of BP control was greater, as shown by smaller values for median absolute performance error, in the bolus group (median 4.38 [quartiles 3.22, 6.25] %) versus the infusion group (5.39 [4.12, 7.04] %, P = .008). In the bolus group, phenylephrine consumption was smaller; this was associated with smaller values for median performance error compared with the continuous infusion group (P < .001), which indicates that values for systolic BP, averaged over time, were slightly lower in the bolus group. There were no differences in cardiac output, nausea or vomiting, or neonatal outcome between groups. CONCLUSIONS: We confirmed the hypothesis that BP control was more precise when computer-controlled phenylephrine was delivered using intermittent boluses rather than continuous infusion. However, the difference between groups was small and was not associated with any difference in clinical outcomes. In the infusion group, greater doses of phenylephrine were delivered, which was related to the time taken for the noninvasive BP monitor to complete measurements. The use of intermittent boluses may be a useful alternative in the design of closed-loop vasopressor systems.
[Mh] Termos MeSH primário: Anestesia Obstétrica/métodos
Raquianestesia/métodos
Pressão Sanguínea/efeitos dos fármacos
Quimioterapia Assistida por Computador
Fenilefrina/administração & dosagem
[Mh] Termos MeSH secundário: Adulto
Anestesia
Determinação da Pressão Arterial
Débito Cardíaco/efeitos dos fármacos
Cesárea
Computadores
Método Duplo-Cego
Sistemas de Liberação de Medicamentos/instrumentação
Retroalimentação
Feminino
Hemodinâmica
Seres Humanos
Hipotensão/tratamento farmacológico
Infusões Intravenosas
Gravidez
Reprodutibilidade dos Testes
Método Simples-Cego
Fatores de Tempo
Vasoconstritores/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Vasoconstrictor Agents); 1WS297W6MV (Phenylephrine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE
[do] DOI:10.1213/ANE.0000000000001974


  7 / 1590 MEDLINE  
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[PMID]:28319511
[Au] Autor:Lin OS; Kozarek RA; Tombs D; La Selva D; Weigel W; Beecher R; Jensen A; Gluck M; Ross A
[Ad] Endereço:From the *Digestive Disease Institute and †Department of Anesthesia, Virginia Mason Medical Center, Seattle, Washington.
[Ti] Título:The First US Clinical Experience With Computer-Assisted Propofol Sedation: A Retrospective Observational Comparative Study on Efficacy, Safety, Efficiency, and Endoscopist and Patient Satisfaction.
[So] Source:Anesth Analg;125(3):804-811, 2017 Sep.
[Is] ISSN:1526-7598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Computer-assisted propofol sedation (CAPS) is now approved for moderate sedation of American Society of Anesthesiologists (ASA) class I and II patients undergoing routine endoscopy. As the first US medical center to adopt CAPS for routine clinical use, we compared patient and endoscopist satisfaction with CAPS versus midazolam and fentanyl (MF) sedation. METHODS: Patients who underwent elective outpatient upper endoscopy and colonoscopy with CAPS were compared with concurrent patients sedated with MF. The primary end points were patient satisfaction (measured by the validated Patient Sedation Satisfaction Index [PSSI]), and endoscopist satisfaction (Clinician Sedation Satisfaction Index [CSSI]). Secondary end points included procedural success rates, polyp detection rates, adverse events, and procedure/recovery times. Multivariable regression was used for comparative analysis. RESULTS: CAPS was utilized to sedate 244 patients, of whom 55 underwent upper endoscopy, 173 colonoscopy, and 16 double procedures. During the same period, 75 upper endoscopies, 223 colonoscopies, and 30 doubles were performed with MF on similar patients. For upper endoscopy, the procedural success rate was 98.2% for CAPS versus 98.7% for MF (P = .96), whereas for colonoscopy, the success rate was 98.9% vs 98.8% (P = .59). Colonoscopic polyp detection rate was 54.5% for CAPS and 59.3% for MF (P = .67). Procedure times were similar between CAPS and MF. For CAPS, the mean recovery time was 26.4 vs 39.1 minutes for MF (P < .001). One CAPS patient required mask ventilation, 4 experienced asymptomatic hypotension or desaturation, and 5 experienced marked agitation resulting from undersedation. For MF, 5 patients had hypotension or desaturation, and 8 experienced undersedation. For colonoscopy, the CAPS group had higher PSSI scores for sedation adequacy, the recovery process and global satisfaction, and higher CSSI scores for ease of sedation administration, the recovery process and global satisfaction. For upper endoscopy and doubles, the CAPS CSSI score was higher for the recovery process only. All P values were adjusted for confounding by using regression analysis. CONCLUSIONS: In low-risk patients, CAPS appears to be effective and efficient. CAPS is associated with higher satisfaction than MF for colonoscopies and, to a lesser extent, upper endoscopies.
[Mh] Termos MeSH primário: Anestesiologistas
Sedação Consciente/métodos
Quimioterapia Assistida por Computador/métodos
Endoscopia/métodos
Satisfação do Paciente
Propofol/administração & dosagem
[Mh] Termos MeSH secundário: Idoso
Anestesiologistas/psicologia
Sedação Consciente/efeitos adversos
Quimioterapia Assistida por Computador/efeitos adversos
Endoscopia/efeitos adversos
Feminino
Seres Humanos
Hipnóticos e Sedativos/administração & dosagem
Hipotensão/etiologia
Masculino
Meia-Idade
Estudos Prospectivos
Estudos Retrospectivos
Resultado do Tratamento
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Hypnotics and Sedatives); YI7VU623SF (Propofol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170321
[St] Status:MEDLINE
[do] DOI:10.1213/ANE.0000000000001898


  8 / 1590 MEDLINE  
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[PMID]:28303793
[Au] Autor:Anelone AJ; Spurgeon SK
[Ad] Endereço:School of Engineering and Digital Arts, The University of Kent, U.K.
[Ti] Título:Prediction of the containment of HIV infection by antiretroviral therapy - a variable structure control approach.
[So] Source:IET Syst Biol;11(1):44-53, 2017 02.
[Is] ISSN:1751-8849
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:It is demonstrated that the reachability paradigm from variable structure control theory is a suitable framework to monitor and predict the progression of the human immunodeficiency virus (HIV) infection following initiation of antiretroviral therapy (ART). A manifold is selected which characterises the infection-free steady-state. A model of HIV infection together with an associated reachability analysis is used to formulate a dynamical condition for the containment of HIV infection on the manifold. This condition is tested using data from two different HIV clinical trials which contain measurements of the CD4+ T cell count and HIV load in the peripheral blood collected from HIV infected individuals for the six month period following initiation of ART. The biological rates of the model are estimated using the multi-point identification method and data points collected in the initial period of the trial. Using the parameter estimates and the numerical solutions of the model, the predictions of the reachability analysis are shown to be consistent with the clinical diagnosis at the conclusion of the trial. The methodology captures the dynamical characteristics of eventual successful, failed and marginal outcomes. The findings evidence that the reachability analysis is an appropriate tool to monitor and develop personalised antiretroviral treatment.
[Mh] Termos MeSH primário: Antirretrovirais/uso terapêutico
Linfócitos T CD4-Positivos/patologia
Quimioterapia Assistida por Computador/métodos
Infecções por HIV/diagnóstico
Infecções por HIV/prevenção & controle
Modelos Biológicos
Carga Viral/efeitos dos fármacos
[Mh] Termos MeSH secundário: Linfócitos T CD4-Positivos/efeitos dos fármacos
Simulação por Computador
Progressão da Doença
Infecções por HIV/sangue
Seres Humanos
Prognóstico
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Retroviral Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170318
[St] Status:MEDLINE
[do] DOI:10.1049/iet-syb.2016.0028


  9 / 1590 MEDLINE  
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[PMID]:28303789
[Au] Autor:Rigatos G; Zervos N; Melkikh A
[Ad] Endereço:Unit of Industrial Automation, Industrial Systems Institute, Rion Patras 26504, Greece. grigat@ieee.org.
[Ti] Título:Flatness-based control approach to drug infusion for cardiac function regulation.
[So] Source:IET Syst Biol;11(1):8-18, 2017 02.
[Is] ISSN:1751-8849
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A new control method based on differential flatness theory is developed in this study, aiming at solving the problem of regulation of haemodynamic parameters. Actually control of the cardiac output (volume of blood pumped out by heart per unit of time) and of the arterial blood pressure is achieved through the administered infusion of cardiovascular drugs such as dopamine and sodium nitroprusside. Time delays between the control inputs and the system's outputs are taken into account. Using the principle of dynamic extension, which means that by considering certain control inputs and their derivatives as additional state variables, a state-space description for the heart's function is obtained. It is proven that the dynamic model of the heart is a differentially flat one. This enables its transformation into a linear canonical and decoupled form, for which the design of a stabilising feedback controller becomes possible. The proposed feedback controller is of proven stability and assures fast and accurate tracking of the reference setpoints by the outputs of the heart's dynamic model. Moreover, by using a Kalman filter-based disturbances' estimator, it becomes possible to estimate in real-time and compensate for the model uncertainty and external perturbation inputs that affect the heart's model.
[Mh] Termos MeSH primário: Pressão Arterial/efeitos dos fármacos
Pressão Arterial/fisiologia
Débito Cardíaco/efeitos dos fármacos
Débito Cardíaco/fisiologia
Fármacos Cardiovasculares/administração & dosagem
Quimioterapia Assistida por Computador/métodos
Modelos Cardiovasculares
[Mh] Termos MeSH secundário: Animais
Simulação por Computador
Relação Dose-Resposta a Droga
Seres Humanos
Infusões Intra-Arteriais
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cardiovascular Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170318
[St] Status:MEDLINE
[do] DOI:10.1049/iet-syb.2016.0012


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[PMID]:28113251
[Au] Autor:Tylcz JB; Bastogne T; Bourguignon A; Frochot C; Barberi-Heyob M
[Ti] Título:Realtime Tracking of the Photobleaching Trajectory During Photodynamic Therapy.
[So] Source:IEEE Trans Biomed Eng;64(8):1742-1749, 2017 Aug.
[Is] ISSN:1558-2531
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Photodynamic therapy (PDT) is an alternative treatment for cancer, which involves the administration of a photosensitizing agent that is activated by light at a specific wavelength. This illumination causes after a sequence of photoreactions, the production of reactive oxygen species responsible for the death of the tumor cells but also the degradation of the photosensitizing agent, which then loose the fluorescence properties. The phenomenon is commonly known as the photobleaching process and can be considered as a therapy efficiency indicator. METHODS: This paper presents the design and validation of a real-time controller able to track a preset photobleaching trajectory by modulating the light impulses width during the treatment sessions. RESULTS: This innovative solution was validated by in vivo experiments that have shown a significantly improvement of reproducibility of the interindividual photobleaching kinetic. CONCLUSION: We believe that this approach could lead to personalized PDT modalities. SIGNIFICANCE: This work may open new perspectives in the control and optimization of photodynamic treatments.
[Mh] Termos MeSH primário: Monitoramento de Medicamentos/métodos
Neoplasias Experimentais/química
Neoplasias Experimentais/tratamento farmacológico
Fotodegradação/efeitos da radiação
Fotoquimioterapia/métodos
Fármacos Fotossensibilizantes/administração & dosagem
Fármacos Fotossensibilizantes/química
[Mh] Termos MeSH secundário: Animais
Sistemas de Computação
Relação Dose-Resposta à Radiação
Quimioterapia Assistida por Computador/métodos
Cinética
Luz
Fármacos Fotossensibilizantes/efeitos da radiação
Dose de Radiação
Radiometria/métodos
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Photosensitizing Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170124
[St] Status:MEDLINE
[do] DOI:10.1109/TBME.2016.2620239



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