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[PMID]:29172937
[Au] Autor:Reddy SV; Husain D
[Ad] Endereço:a Retina Service , Massachusetts Eye and Ear, Harvard Medical School , Boston , MA , USA.
[Ti] Título:Panretinal Photocoagulation: A Review of Complications.
[So] Source:Semin Ophthalmol;33(1):83-88, 2018.
[Is] ISSN:1744-5205
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Panretinal photocoagulation (PRP) is a mainstay of therapy for retinal ischemic disease. The procedure involves creating thermal burns in the peripheral retina leading to tissue coagulation, the overall consequence of which is improved retinal oxygenation. While highly effective, there have been concerns historically regarding the anatomic effects and visual complications following PRP, the most common of which include choroidal effusions, exudative retinal detachments, macular edema, visual field deficits, and night vision defects. The occurrence of these complications is closely tied to laser parameters such as increased duration and power and intensive treatment in a single sitting, all of which cause increased dispersion of thermal energy within the retina and choroid. The advent of newer laser delivery systems, such as the multispot pattern laser, has greatly mitigated but not eliminated these issues. The following article reviews the most common complications following PRP treatment, including reported occurrences, inciting factors, and underlying pathophysiology.
[Mh] Termos MeSH primário: Fotocoagulação/efeitos adversos
Procedimentos Cirúrgicos Oftalmológicos/efeitos adversos
Complicações Pós-Operatórias
Doenças Retinianas/cirurgia
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1080/08820538.2017.1353820


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[PMID]:28467586
[Au] Autor:Yazgan S; Ayar O; Akdemir O; Koban Y
[Ti] Título:An excellent anatomical and visual recovery after surgical repair of an open eye injury with poor baseline prognostic factors.
[So] Source:Ulus Travma Acil Cerrahi Derg;23(2):167-169, 2017 Mar.
[Is] ISSN:1306-696X
[Cp] País de publicação:Turkey
[La] Idioma:eng
[Ab] Resumo:Presently described is case of a 42-year-old woman with eye injury that was result of gunshot fired by a man at a wedding celebration. Bullet penetrated inferior quadrant of nasal sclera of left eye 7-12 mm behind limbus. Choroid and vitreous were prolapsed around bullet. Hemorrhage, vitreous prolapse and lens subluxation were present in anterior chamber. Presenting visual acuity (VA) was hand motion. Bullet 14x5 mm in size was carefully extracted from the eye. Fifteen days later, argon laser photocoagulation was performed on retina in area of bullet entry point. VA was 20/25 (Snellen) at final visit. In this case, although foreign body was large, area of penetration was Zone III, and initial VA was poor, early and appropriate surgical repair achieved integrity of the globe and good vision prognosis.
[Mh] Termos MeSH primário: Ferimentos Oculares Penetrantes
Ferimentos por Arma de Fogo
[Mh] Termos MeSH secundário: Adulto
Ferimentos Oculares Penetrantes/diagnóstico
Ferimentos Oculares Penetrantes/fisiopatologia
Ferimentos Oculares Penetrantes/cirurgia
Feminino
Seres Humanos
Fotocoagulação
Prognóstico
Acuidade Visual
Ferimentos por Arma de Fogo/diagnóstico
Ferimentos por Arma de Fogo/fisiopatologia
Ferimentos por Arma de Fogo/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.5505/tjtes.2016.23790


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[PMID]:28984756
[Au] Autor:Zhong J; Jia J; Yu J; Zhang L; Xiang Y
[Ad] Endereço:Department of Ophthalmology, Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
[Ti] Título:Preoperative photocoagulation reduces corneal endothelial cell damage after vitrectomy in patients with proliferative diabetic retinopathy.
[So] Source:Medicine (Baltimore);96(40):e7971, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Proliferative diabetic retinopathy (PDR) is a severe complication of diabetes and is a leading cause of visual decline and irreversible blindness. So we designed this study to investigate retrospectively the effect of preoperative photocoagulation on corneal endothelial cells after vitrectomy in patients with PDR.The study included 52 eyes of 46 patients with PDR complicated with vitreous hemorrhage, who underwent vitrectomy. Patients were apportioned to a photocoagulation group (26 eyes/23 patients) or nonphotocoagulation group (26/23 patients), according to their history of preoperative photocoagulation. A specular microscope was used to assess the corneal endothelial cell density and percentage of hexagonal cells (PHC) before surgery, and at 1 week, 1 month, and 3 months after surgery.The cell density was lower 3 months after surgery in the photocoagulation group, but at 1 month in the nonphotocoagulation group, all cases were significantly different from the preoperative value (P < .05 or P < .01). One week after surgery, the mean cell densities between the photocoagulation and nonphotocoagulation groups were not statistically different (P > .05). However, the mean cell densities at 1 and 3 months after surgery in the photocoagulation group were significantly higher than those in the nonphotocoagulation group (P < .05). The PHC values in the photocoagulation group at 1 week and in the nonphotocoagulation group at 1 week, 1 month, and 3 months were much lower than their respective preoperative values (P < .05 or P < .01). More importantly, at 1 and 3 months, the PHC had recovered to preoperative values in the photocoagulation group, but not in the nonphotocoagulation group. As for cell density and PHC, they were both significantly higher 1 and 3 months after surgery in the photocoagulation group than in the nonphotocoagulation group (P < .05).Photocoagulation before vitrectomy reduces subsequent corneal endothelial cell damage in PDR patients.
[Mh] Termos MeSH primário: Perda de Células Endoteliais da Córnea/prevenção & controle
Retinopatia Diabética/cirurgia
Fotocoagulação/métodos
Complicações Pós-Operatórias/prevenção & controle
Cuidados Pré-Operatórios/métodos
Vitrectomia/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Perda de Células Endoteliais da Córnea/etiologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Complicações Pós-Operatórias/etiologia
Estudos Retrospectivos
Resultado do Tratamento
Vitrectomia/efeitos adversos
Adulto Jovem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007971


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[PMID]:28932922
[Au] Autor:Matsumoto T; Itokawa T; Shiba T; Tomita M; Hine K; Mizukaki N; Yoda H; Hori Y
[Ad] Endereço:Department of Ophthalmology, School of Medicine, Toho University, 6-11-1 Omori-Nishi, Ota-ku, Tokyo, 143-8541, Japan. matsu-t@med.toho-u.ac.jp.
[Ti] Título:Decreased ocular blood flow after photocoagulation therapy in neonatal retinopathy of prematurity.
[So] Source:Jpn J Ophthalmol;61(6):484-493, 2017 Nov.
[Is] ISSN:1613-2246
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To evaluate the relationships between optic nerve head blood flow, expressed as mean blur rate (MBR) measured by laser speckle flowgraphy (LSFG), and photocoagulation therapy in neonates with retinopathy of prematurity (ROP). STUDY DESIGN: Case series study. METHODS: We studied 5 ROP neonates either during sleep or under sedation both before and after photocoagulation, and evaluated 8 eyes in which the circulation could be measured three times consecutively. Correlations between the MBR-A (mean of all values), MBR-V (vessel mean) and MBR-T (tissue mean) and postmenstrual age were evaluated using Spearman's rank correlation coefficient. In addition, correlations between the relative MBR (-A, -V, -T) value and number of photocoagulation burns and the NV score were evaluated. Differences between post-treatment MBR in ROP subjects and normal neonates' MBR were estimated using analysis of covariance (ANCoVA), with adjustment for postmenstrual age. RESULTS: The relative MBR (-A, -V, -T) values after photocoagulation were 69.6 ± 16.0%, 66.7 ± 17.0% and 74.3 ± 14.6%, respectively. Postmenstrual age was significantly correlated with post-treatment MBR-A (r = 0.83, p = 0.0101), MBR-V (r = 0.85, p = 0.007) and MBR-T (r = 0.76, p = 0.0282). The relative MBR-T value was significantly correlated with the number of photocoagulation burns (r = -0.75, p = 0.033) and NV score (r = -0.72, p = 0.0437). The ANCoVA results showed no significant difference between post-treatment MBR and normal neonates' MBR. CONCLUSIONS: Photocoagulation improved the dilation of veins and tortuosity of arteries and reduced ocular blood flow in ROP subjects. Since the post-treatment MBR was not different from a normal neonate's MBR, it is suggested that the pre-treatment MBR was higher in severe ROP cases.
[Mh] Termos MeSH primário: Velocidade do Fluxo Sanguíneo/fisiologia
Fotocoagulação/métodos
Microcirculação/fisiologia
Disco Óptico/irrigação sanguínea
Fluxo Sanguíneo Regional/fisiologia
Retinopatia da Prematuridade/fisiopatologia
[Mh] Termos MeSH secundário: Feminino
Seguimentos
Seres Humanos
Lactente
Fluxometria por Laser-Doppler/métodos
Masculino
Período Pós-Operatório
Retinopatia da Prematuridade/diagnóstico
Retinopatia da Prematuridade/cirurgia
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE
[do] DOI:10.1007/s10384-017-0536-7


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[PMID]:28880961
[Au] Autor:Shiraya T; Kato S; Araki F; Ueta T; Abe H; Asai N
[Ad] Endereço:Department of Ophthalmology, Graduate School of Medicine, Tokyo, Japan.
[Ti] Título:Experimental verification of subthreshold laser therapy using conventional pattern scan laser.
[So] Source:PLoS One;12(9):e0184392, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Leading-edge therapeutic laser technologies are not available at every medical facility; therefore, alternative approaches incorporating novel advances in digital and laser technology into more readily available conventional methods have generated significant research interest. Using a rabbit model, this study investigated whether the algorithm used in the Endpoint Management (EM) software system of the latest devices could enable subthreshold laser treatment in conventional retinal tissue laser therapy systems. MATERIALS AND METHODS: Two types of devices were used, the PASCAL Streamline 577 and the MC 500-Vixi™, and the laser method was classified into three categories: EM; single-shot using PASCAL with arbitrary energy settings (PSS-SDM); and MC500-VixiTM (VX-SDM), which were performed in eight eyes from four Dutch-Belted rabbits. In EM, 100 mW (100%) was set as a landmark, and the laser energy parameters were gradually decreased to 80%, 60%, 50%, 40%, 30%, 20%, and 10%, using a 2 × 3 square pattern. In PSS-SDM and VX-SDM, as control, the laser energy was gradually decreased to 100, 80, 60, 50, 40, 30, 20, and 10 mW. The laser settings were fixed at 200 µm, 20 ms, and a wavelength of 577 µm. To identify and compare the extent of tissue damage at each spot size, optical coherence tomography (OCT) and histological findings were used to construct a three-dimensional histopathology image using a confocal laser scanning fluorescence microscope. RESULTS: The spot size at 50% setting on EM was 7183 µm2; PSS-SDM required 50 mW (5503 µm2) to 60 mW (10279 µm2) and VX-SDM required 50 mW (7423 µm2) to create the approximate spot size. Furthermore, at 50 mW of PSS-SDM and VX-SDM, the extent of tissue damage in all three methods was generally in accord with the outer nuclear layer by OCT and inner nuclear layer by histopathological imaging. CONCLUSION: These findings suggest that it may be possible to perform subthreshold laser therapy using approximations from the EM algorithm.
[Mh] Termos MeSH primário: Edema Macular/terapia
Software
[Mh] Termos MeSH secundário: Algoritmos
Animais
Seres Humanos
Fotocoagulação a Laser
Fotocoagulação
Microscopia Confocal
Coelhos
Tomografia de Coerência Óptica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170908
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184392


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[PMID]:28763561
[Au] Autor:Zhang L; Li G; Shi M; Liu HH; Ge S; Ou Y; Flanagan JG; Chen L
[Ad] Endereço:Center for Eye Disease and Development, Vision Science Graduate Program, University of California, Berkeley, California, United States 2School of Optometry and Vision Science, University of California, Berkeley, California, United States 3Department of Ophthalmology, Second Xiangya Hospital, Central
[Ti] Título:Establishment and Characterization of an Acute Model of Ocular Hypertension by Laser-Induced Occlusion of Episcleral Veins.
[So] Source:Invest Ophthalmol Vis Sci;58(10):3879-3886, 2017 Aug 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: This study was designed to develop and characterize a laser-induced model of acute intraocular hypertension that permits the study of the anterior segment of the eye. Methods: CD1 mice aged 5 and 8 weeks were examined for elevation of IOP induced by laser photocoagulation. We compared between occlusion of episcleral veins alone and when combined with 270° limbal vessel occlusion. Anterior chamber angle, corneal thickness, and retinal nerve fiber layer (RNFL) thickness were evaluated by anterior- and posterior-segment optical coherence tomography (OCT). Additionally, at day 7 post-procedure, the anterior segment was evaluated for inflammatory cellular presentation by histologic analysis and OCT, and limbal vessels and whole-mount retina were immunostained for CD31 and Brn3a, respectively. Brn3a-positive retinal ganglion cells (RGCs) were quantified with ImageJ software. Results: After single or combined laser treatment in mice aged 5 or 8 weeks, IOP was significantly elevated for 5 to 6 days before returning to the baseline by day 7 post-procedure. Anterior segment assessment indicated less synechiae in the anterior chamber angle and better preserved limbal vessels with single versus combined laser treatment. Corneal thickness was significantly increased after single or combined treatment. No inflammatory cells were detected in the anterior chamber. The thickness of the RNFL and the density of RGCs were both significantly reduced after single or combined treatment. Conclusions: Laser photocoagulation of episcleral veins alone in CD1 mice aged 5 to 8 weeks may be used to induce ocular hypertension resulting in RNFL thinning and ganglion cell loss. This model permits the study of the anterior as well as the posterior segment of the eye.
[Mh] Termos MeSH primário: Pressão Intraocular/efeitos da radiação
Fotocoagulação/efeitos adversos
Hipertensão Ocular/patologia
Hipertensão Ocular/fisiopatologia
Oclusão da Veia Retiniana/patologia
[Mh] Termos MeSH secundário: Doença Aguda
Animais
Modelos Animais de Doenças
Limbo da Córnea/irrigação sanguínea
Limbo da Córnea/patologia
Disco Óptico/patologia
Retina/patologia
Células Ganglionares da Retina/patologia
Esclera/irrigação sanguínea
Tomografia de Coerência Óptica
Veias
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170803
[Lr] Data última revisão:
170803
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170802
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.16-20807


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[PMID]:28640115
[Au] Autor:Zhao X; Wang Z; Yang X
[Ad] Endereço:Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
[Ti] Título:Management of neovascular glaucoma with intravitreal ranibizumab, panretinal photocoagulation, and subsequent 5-fluorouracil augmented trabeculectomy: A case report.
[So] Source:Medicine (Baltimore);96(25):e7221, 2017 Jun.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Neovascular glaucoma (NVG) is one of the most refractory types of glaucoma caused by high ischemic retinal disorders, resulting in severe visual loss. Intravitreal injections of ranibizumab have been reported to have anatomical and functional success in treating NVG. PATIENT CONCERNS-DIAGNOSES-INTERVENTIONS: We report a case with neovascular glaucoma due to central retinal vein occlusion who received combination therapy with intravitreal ranibizumab (IVR) injection, panretinal photocoagulation (PRP) and subsequent 5-fluorouracil (5-FU) augmented trabeculectomy. OUTCOMES: One week after IVR injection, the intraocular pressure (IOP) had partially decreased to 33 mmHg, and there was a complete regression of neovascularization of the iris (NVI) and the angle (NVA). PRP was feasible after IVR due to improvement of corneal edema which made an adequate view of the posterior pole of fundus. The surgery of trabeculectomy with 5-FU was performed 2 weeks after IVR to control the IOP. The intraoperative and postoperative courses were uneventful without any adverse complication. Post trabeculectomy, his vision remained stable and the IOP was in the range of 4-15 mmHg without topical antiglaucoma medications. A functioning bleb was maintained and there was no recurrence of NVI and NVA during the complete follow-up period of 6 months. LESSONS: Combined treatment of IVR, PRP, and subsequent 5-FU augmented trabeculectomy is demonstrated to be a possible new paradigm for the management of advanced NVG with angle closure and intractable elevation of IOP.
[Mh] Termos MeSH primário: Glaucoma Neovascular/terapia
[Mh] Termos MeSH secundário: Inibidores da Angiogênese/administração & dosagem
Terapia Combinada
Fluoruracila/uso terapêutico
Glaucoma Neovascular/patologia
Seres Humanos
Imunossupressores/uso terapêutico
Injeções Intravítreas
Fotocoagulação
Masculino
Meia-Idade
Ranibizumab/administração & dosagem
Trabeculectomia
[Pt] Tipo de publicação:CLASSICAL ARTICLE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiogenesis Inhibitors); 0 (Immunosuppressive Agents); U3P01618RT (Fluorouracil); ZL1R02VT79 (Ranibizumab)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007221


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[PMID]:28609419
[Au] Autor:Kumar V; Agarwal R; Chandra P
[Ad] Endereço:*MS, DNB †MBBS ‡MD Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India (all authors).
[Ti] Título:Retinal Macroaneurysm Associated with Congenital Anomalous Retinal Artery.
[So] Source:Optom Vis Sci;94(7):781-785, 2017 Jul.
[Is] ISSN:1538-9235
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Retinal arteriolar macroaneurysms are a common cause of vision loss in elderly patients with hypertension and cardiovascular disease. Their occurrence in the young, however, is not well known. The purpose of this article is to describe an unusual cause of retinal arteriolar macroaneurysm in a healthy young man. CASE REPORT: A 30-year-old man presented with preretinal hemorrhage and macular exudation due to ruptured retinal artery macroaneurysm. The patient was treated with intravitreal bevacizumab and laser photocoagulation to the macroaneurysm. The exudation and preretinal hemorrhage resolved over several months. Fluorescein angiogram at this stage revealed a congenital anomalous retinal artery. CONCLUSIONS: Congenital anomalous retinal artery may be associated with retinal artery macroaneurysm even in the young age in the absence of any other predisposing factors. The presentation and treatment of such retinal artery macroaneurysm, however, may remain the same to those that occur in older patients.
[Mh] Termos MeSH primário: Aneurisma Roto/etiologia
Anormalidades do Olho/complicações
Artéria Retiniana/anormalidades
Doenças Retinianas/etiologia
[Mh] Termos MeSH secundário: Adulto
Inibidores da Angiogênese/uso terapêutico
Bevacizumab/uso terapêutico
Terapia Combinada
Anormalidades do Olho/diagnóstico
Anormalidades do Olho/terapia
Angiofluoresceinografia
Seres Humanos
Injeções Intravítreas
Fotocoagulação
Masculino
Hemorragia Retiniana/etiologia
Fator A de Crescimento do Endotélio Vascular/antagonistas & inibidores
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiogenesis Inhibitors); 0 (VEGFA protein, human); 0 (Vascular Endothelial Growth Factor A); 2S9ZZM9Q9V (Bevacizumab)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170614
[St] Status:MEDLINE
[do] DOI:10.1097/OPX.0000000000001095


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[PMID]:28442697
[Au] Autor:Masis Solano M; Huang G; Lin SC
[Ti] Título:When Should We Give Up Filtration Surgery: Indications, Techniques and Results of Cyclodestruction.
[So] Source:Dev Ophthalmol;59:179-190, 2017.
[Is] ISSN:1662-2790
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Cyclodestructive procedures are traditionally used in cases of glaucoma that are refractory to medical and surgical therapy. The goal of this chapter is to describe the indications, contraindications, techniques, and pitfalls of cyclodestructive procedures, including transscleral cyclophotocoagulation (TCP), micropulse TCP (MP-TCP), endoscopic cyclophotocoagulation (ECP), and ultrasound cilioplasty. METHODS: A literature search for cyclodestructive techniques was performed, and relevant studies were included for evaluation and review. RESULTS: It is encouraging that TCP seems relatively efficacious even for patients who have been refractory to other treatments, depending on the energy setting, follow-up period, and definition of success. Repeated TCP is often required. TCP was more often used in eyes with limited visual potential caused by severe forms of glaucoma than in eyes with good visual potential. Serious complications were significant vision loss, inflammation, hypotony, and phthisis. ECP came later into clinical use for the treatment of refractory glaucoma. ECP is able to specifically target the ciliary epithelium under direct viewing as compared to TCP, which is an indirect cyclodestructive procedure. In the literature, it has been demonstrated that ECP has overall good success with relatively low complication rates when used for adult forms of glaucoma. A new technology using MP-TCP is a promising alternative to conventional cyclophotocoagulation. Early evidence shows that MP-TCP has clinical utility and a good safety profile. Ultrasound cilioplasty is a possible alternative to laser cyclodestruction that is already being commercialized and is currently under investigation. CONCLUSIONS: Both TCP and ECP are effective cyclodestructive procedures and alternatives for the treatment of glaucoma refractory to medical and surgical therapy, though potential for serious complications exists. TCP, ECP, and ultrasound cilioplasty are being used increasingly as the primary surgery for various kinds and stages of glaucoma.
[Mh] Termos MeSH primário: Corpo Ciliar/cirurgia
Cirurgia Filtrante/métodos
Glaucoma/cirurgia
Pressão Intraocular
Fotocoagulação/métodos
Esclera/cirurgia
[Mh] Termos MeSH secundário: Glaucoma/fisiopatologia
Seres Humanos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE
[do] DOI:10.1159/000458496


  10 / 4628 MEDLINE  
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[PMID]:28353121
[Au] Autor:Bak J; Kang HW
[Ad] Endereço:Department of Biomedical Engineering, Pukyong National University, 45 Yongso-ro Nam-gu, Busan, 48513, Republic of Korea.
[Ti] Título:Temperature-monitored optical treatment for radial tissue expansion.
[So] Source:Lasers Med Sci;32(5):993-999, 2017 Jul.
[Is] ISSN:1435-604X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Esophageal stricture occurs in 7-23% of patients with gastroesophageal reflux disease. However, the current treatments including stent therapy, balloon dilation, and bougienage involve limitations such as stent migration, formation of the new strictures, and snowplow effect. The purpose of the current study was to investigate the feasibility of structural expansion in tubular tissue ex vivo during temperature-monitored photothermal treatment with a diffusing applicator for esophageal stricture. Porcine liver was used as an ex vivo tissue sample for the current study. A glass tube was used to maintain a constant distance between the diffuser and tissue surface and to evaluate any variations in the luminal area after 10-W 1470-nm laser irradiation for potential stricture treatment. The 3D goniometer measurements confirmed roughly isotropic distribution with less than 10% deviation from the average angular intensity over 2π (i.e., 0.86 ± 0.09 in arbitrary unit) from the diffusing applicator. The 30-s irradiation increased the tissue temperature up to 72.5 °C, but due to temperature feedback, the interstitial tissue temperature became saturated at 70 °C (i.e., steady-state error = ±0.4 °C). The irradiation times longer than 5 s presented area expansion index of 1.00 ± 0.04, signifying that irreversible tissue denaturation permanently deformed the lumen in a circular shape and secured the equivalent luminal area to that of the glass tube. Application of a temperature feedback controller for photothermal treatment with the diffusing applicator can regulate the degree of thermal denaturation to feasibly treat esophageal stricture in a tubular tissue.
[Mh] Termos MeSH primário: Esôfago/efeitos da radiação
Fenômenos Ópticos
Temperatura Ambiente
Expansão de Tecido
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Lasers
Fotocoagulação
Masculino
Sus scrofa
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170330
[St] Status:MEDLINE
[do] DOI:10.1007/s10103-017-2199-5



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