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[PMID]:29376616
[Au] Autor:Apolikhin OI; Moskvin SV
[Ad] Endereço:N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology branch of NMRRC of Minzdrav of Russia, Moscow, Russia.
[Ti] Título:[Laser therapy for mens infertility. Part 2. Systematic review of clinical trials].
[So] Source:Urologiia;(6):164-171, 2017 Dec.
[Is] ISSN:1728-2985
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Male infertility is a multifactorial syndrome associated with a wide range of pathological conditions affecting both the sexual and other body systems: endocrine, nervous, blood, and immune. Laser therapy is a form of modern physiotherapy that applies low-intensity laser irradiation (LILI) in various parts of the body. It is widely used in all areas of modern medicine due to its high efficiency, ease of use, the absence of contraindications and side effects. The authors reviewed the results of 171 studies investigating laser therapy, of which 93 were experimental (20 in Russian and 73 international publications), four clinical and experimental (all in Russian), 74 clinical (73 in Russian and 1 in English).Along with domestic literature, publications in Russian from Belarus, Georgia, Kyrgyzstan, Uzbekistan, and Ukraine were also reviewed. The review suggests that laser therapy should be used as much as possible in the management of male infertility not just due to high effectiveness, but also because of the lack of alternatives. For local application, optimal laser irradiation regimens are pulsed LILI of red (635 nm) and infrared (904 nm) spectra. For intravenous laser blood irradiation, the authors recommend alternating a continuous LILI with a wavelength of 635 nm (red spectrum) and 365 nm (ultraviolet spectrum).
[Mh] Termos MeSH primário: Infertilidade Masculina/radioterapia
Terapia com Luz de Baixa Intensidade/métodos
[Mh] Termos MeSH secundário: Ensaios Clínicos como Assunto
Seres Humanos
Infertilidade Masculina/patologia
Infertilidade Masculina/fisiopatologia
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180130
[St] Status:MEDLINE


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[PMID]:29267668
[Au] Autor:Costa SAP; Florezi GP; Artes GE; Costa JRD; Gallo RT; Freitas PM; Witzel AL
[Ad] Endereço:Universidade de São Paulo, School of Dentistry, Department of Stomatology, São Paulo, SP, Brazil.
[Ti] Título:The analgesic effect of photobiomodulation therapy (830 nm) on the masticatory muscles: a randomized, double-blind study.
[So] Source:Braz Oral Res;31:e107, 2017 Dec 18.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:This study assesses the efficacy of photobiomodulation therapy (830 nm) for myalgia treatment of masticatory muscles. Sixty patients with muscular myalgia were selected and randomly allocated into 2 groups (n=30): Group A comprised patients given a placebo (control), and Group B consisted of those undergoing photobiomodulation therapy (PBMT). PBMT and placebo were applied bilaterally to specific points on the masseter and temporal muscles. Referred pain elicited by palpation and maximum mouth opening were measured before (EV1) and after (EV2) the treatments. The data were analyzed using statistical tests, considering a significance level of 5%. No significant differences in range were observed for active or passive mouth opening (p ≥ 0.05). Comparing the final outcomes (EV1-EV2) of both treatments, statistical significance was verified for total pain in the right masseter muscle (p = 0.001) and total pain (p = 0.005). In EV2, significant differences in pain reported with palpation were found between Groups A and B for the following: left posterior temporal muscle (p = 0.025), left superior masseter muscle (p = 0.036), inferior masseter muscle (p = 0.021), total pain (left side) (p = 0.009), total masseter muscle (left side) (p = 0.014), total temporal (left side) (p = 0.024), and total pain (p = 0.035). We concluded that PBMT (830 nm) reduces pain in algic points, but does not influence the extent of mouth opening in patients with myalgia.
[Mh] Termos MeSH primário: Terapia com Luz de Baixa Intensidade/métodos
Músculo Masseter/efeitos da radiação
Mialgia/radioterapia
Músculo Temporal/efeitos da radiação
Transtornos da Articulação Temporomandibular/radioterapia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Dor Crônica/radioterapia
Método Duplo-Cego
Feminino
Seres Humanos
Masculino
Meia-Idade
Medição da Dor
Dose de Radiação
Valores de Referência
Reprodutibilidade dos Testes
Estatísticas não Paramétricas
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


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[PMID]:29216916
[Au] Autor:Baxter GD; Liu L; Petrich S; Gisselman AS; Chapple C; Anders JJ; Tumilty S
[Ad] Endereço:Centre for Health, Activity and Rehabilitation Research, School of Physiotherapy, University of Otago, Dunedin, New Zealand. david.baxter@otago.ac.nz.
[Ti] Título:Low level laser therapy (Photobiomodulation therapy) for breast cancer-related lymphedema: a systematic review.
[So] Source:BMC Cancer;17(1):833, 2017 12 07.
[Is] ISSN:1471-2407
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Breast cancer related lymphedema (BCRL) is a prevalent complication secondary to cancer treatments which significantly impacts the physical and psychological health of breast cancer survivors. Previous research shows increasing use of low level laser therapy (LLLT), now commonly referred to as photobiomodulation (PBM) therapy, for BCRL. This systematic review evaluated the effectiveness of LLLT (PBM) in the management of BCRL. METHODS: Clinical trials were searched in PubMed, AMED, Web of Science, and China National Knowledge Infrastructure up to November 2016. Two reviewers independently assessed the methodological quality and adequacy of LLLT (PBM) in these clinical trials. Primary outcome measures were limb circumference/volume, and secondary outcomes included pain intensity and range of motion. Because data were clinically heterogeneous, best evidence synthesis was performed. RESULTS: Eleven clinical trials were identified, of which seven randomized controlled trials (RCTs) were chosen for analysis. Overall, the methodological quality of included RCTs was high, whereas the reporting of treatment parameters was poor. Results indicated that there is strong evidence (three high quality trials) showing LLLT (PBM) was more effective than sham treatment for limb circumference/volume reduction at a short-term follow-up. There is moderate evidence (one high quality trial) indicating that LLLT (PBM) was more effective than sham laser for short-term pain relief, and limited evidence (one low quality trial) that LLLT (PBM) was more effective than no treatment for decreasing limb swelling at short-term follow-up. CONCLUSIONS: Based upon the current systematic review, LLLT (PBM) may be considered an effective treatment approach for women with BCRL. Due to the limited numbers of published trials available, there is a clear need for well-designed high-quality trials in this area. The optimal treatment parameters for clinical application have yet to be elucidated.
[Mh] Termos MeSH primário: Linfedema Relacionado a Câncer de Mama/terapia
Terapia com Luz de Baixa Intensidade
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Ensaios Clínicos Controlados Aleatórios como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180217
[Lr] Data última revisão:
180217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE
[do] DOI:10.1186/s12885-017-3852-x


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[PMID]:28468163
[Au] Autor:Abukawa H; Kono M; Hamada H; Okamoto A; Satomi T; Chikazu D
[Ad] Endereço:*Oral and Maxillofacial Surgery Service, Tokyo Medical University Hachioji Medical Center †Department of Oral and Maxillofacial Surgery, Tokyo Medical University Hospital, Tokyo ‡Oral and Maxillofacial Surgery Service, Tokyo Medical University Ibaraki Medical Center, Ibaraki §Department of Oral and Maxillofacial Surgery, Tokyo Medical University, Tokyo, Japan.
[Ti] Título:Indications of Potassium Titanyl Phosphate Laser Therapy for Slow-Flow Vascular Malformations in Oral Region.
[So] Source:J Craniofac Surg;28(3):771-774, 2017 May.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Indications for laser therapy for slow-flow vascular malformations in the oral and maxillofacial regions have not been clearly documented. The authors aimed to estimate the frequency of resolution of slow-flow vascular malformations and to identify risk and prognostic factors associated with resolution in potassium titanyl phosphate (KTP) laser treatment. METHODS: This study was designed as a prospective cohort study. Patients who had diagnosed slow-flow vascular malformations were continuously assigned to receive KTP laser therapy. All patients had intralesional laser photocoagulation performed under local anesthesia. Administered power of the KTP laser was fixed at 2 watts throughout the procedure in all patients. The primary endpoint was to understand the frequency of resolution of slow-flow vascular malformations in KTP laser treatment. Secondary endpoints were: treatment outcomes based on lesion size; treatment outcomes based on location; treatment outcomes based on total energy in joules; types of complications. Treatment outcomes were judged by a clinical assessment as well as reduction in lesion size on magnetic resonance imaging. RESULTS: Data were obtained from 26 patients (9 men, 17 women) with 38 lesions. The average lesion size was 13.5 ±â€Š7.7 mm. Treatment outcomes based on lesion size showed that cure and regression were obtained in lesions less than 30 mm in size. However, lesions larger than 30 mm showed no response. Lesions in the tongue and lips showed higher cure rates than in other areas. Treatment outcomes based on administered total energy in joules showed that 68% of lesions were treated and responded well at less than 400 joules. Complication rate was relatively high in the buccal mucosal lesions. Immediate postoperative complications such as necrosis were more common in high-energy administration than in low-energy administration. CONCLUSION: Our results indicated that KTP laser therapy was effective for slow-flow vascular malformations less than 30 mm in size without significant side effects.
[Mh] Termos MeSH primário: Velocidade do Fluxo Sanguíneo/fisiologia
Terapia a Laser/métodos
Lasers de Estado Sólido/uso terapêutico
Boca/irrigação sanguínea
Fosfatos
Cirurgia Bucal/métodos
Titânio
Malformações Vasculares/cirurgia
[Mh] Termos MeSH secundário: Feminino
Seguimentos
Hemodinâmica
Seres Humanos
Terapia com Luz de Baixa Intensidade/métodos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Estudos Prospectivos
Resultado do Tratamento
Ultrassonografia Doppler em Cores
Malformações Vasculares/diagnóstico
Malformações Vasculares/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phosphates); 12690-20-9 (potassium titanylphosphate); D1JT611TNE (Titanium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003445


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[PMID]:29211392
[Au] Autor:Buck ML; Eckereder G; Amir LH
[Ti] Título:Low level laser therapy for breastfeeding problems.
[So] Source:Breastfeed Rev;24(2):27-31, 2016 Jul.
[Is] ISSN:0729-2759
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Breast and nipple pain, nipple damage and mastitis are common reasons given by women for their early cessation of breastfeeding. There are a limited number of effective therapies available to support healing of damaged nipples during lactation. Low level laser therapy is a painless treatment, which appears to accelerate wound healing and ease pain. We present two case studies, which demonstrate the use of low level laser therapy in clinical practice.
[Mh] Termos MeSH primário: Doenças Mamárias/radioterapia
Aleitamento Materno/efeitos adversos
Terapia com Luz de Baixa Intensidade/métodos
Mamilos/efeitos da radiação
[Mh] Termos MeSH secundário: Adulto
Doenças Mamárias/etiologia
Feminino
Seres Humanos
Manejo da Dor/métodos
Medição da Dor
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:K
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


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[PMID]:28922374
[Au] Autor:Kawakubo M; Demehri S; Manstein D
[Ad] Endereço:Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital Research Institute, Charlestown, MA, United States of America.
[Ti] Título:Fractional laser exposure induces neutrophil infiltration (N1 phenotype) into the tumor and stimulates systemic anti-tumor immune response.
[So] Source:PLoS One;12(9):e0184852, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Ablative fractional photothermolysis (aFP) using a CO2 laser generates multiple small diameter tissue lesions within the irradiation field. aFP is commonly used for a wide variety of dermatological indications, including treatment of photodamaged skin and dyschromia, drug delivery and modification of scars due to acne, surgical procedures and burns. In this study we explore the utility of aFP for treating oncological indications, including induction of local tumor regression and inducing anti-tumor immunity, which is in marked contrast to current indications of aFP. METHODOLOGY/PRINCIPAL FINDINGS: We used a fractional CO2 laser to treat a tumor established by BALB/c colon carcinoma cell line (CT26.CL25), which expressed a tumor antigen, beta-galactosidase (beta-gal). aFP treated tumors grew significantly slower as compared to untreated controls. Complete remission after a single aFP treatment was observed in 47% of the mice. All survival mice from the tumor inoculation rejected re-inoculation of the CT26.CL25 colon carcinoma cells and moreover 80% of the survival mice rejected CT26 wild type colon carcinoma cells, which are parental cells of CT26.CL25 cells. Histologic section of the FP-treated tumors showed infiltrating neutrophil in the tumor early after aFP treatment. Flow cytometric analysis of tumor-infiltrating lymphocytes showed aFP treatment abrogated the increase in regulatory T lymphocyte (Treg), which suppresses anti-tumor immunity and elicited the expansion of epitope-specific CD8+ T lymphocytes, which were required to mediate the tumor-suppressing effect of aFP. CONCLUSION: We have demonstrated that aFP is able to induce a systemic anti-tumor adaptive immunity preventing tumor recurrence in a murine colon carcinoma in a mouse model. This study demonstrates a potential role of aFP treatments in oncology and further studies should be performed.
[Mh] Termos MeSH primário: Neoplasias do Colo
Imunidade Celular
Lasers
Terapia com Luz de Baixa Intensidade/métodos
Infiltração de Neutrófilos
Neutrófilos/imunologia
Linfócitos T Reguladores/metabolismo
[Mh] Termos MeSH secundário: Animais
Linfócitos T CD8-Positivos/imunologia
Linhagem Celular Tumoral
Neoplasias do Colo/imunologia
Neoplasias do Colo/radioterapia
Feminino
Camundongos
Camundongos Endogâmicos BALB C
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184852


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Texto completo SciELO Brasil
[PMID]:28877277
[Au] Autor:Swerts AA; Santos BFE; Bruzadelli SR; Brigagão MRPL; Lima DC; Fernandes LA
[Ad] Endereço:Universidade Federal de Alfenas, Faculdade de Odontologia, Departamento de Clínica e Cirurgia, Alfenas, MG, Brasil.
[Ti] Título:Treatment of experimental periodontal disease by laser therapy in simvastatin-modified rats.
[So] Source:J Appl Oral Sci;25(4):387-395, 2017 Jul-Aug.
[Is] ISSN:1678-7765
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Objective: The aim of this study was to evaluate low-level laser therapy (LLLT) as an adjuvant treatment for scaling and root planing (SRP) for the treatment of induced periodontitis in simvastatin-modified rats. Material and Methods: A total of 180 rats were evenly divided into two groups: Veh - receiving oral administration of polyethylene glycol (vehicle); S - receiving oral administration of Simvastatin. Periodontal disease was induced in both groups at the first mandibular molar. After seven days, the ligature was removed and the animals were divided into subgroups according to the following local treatments: NT - no treatment; SRP - scaling and root planing and irrigation with saline solution; and LLLT ¬- SRP and laser irradiation (660 nm; 0.03 W; 4 J). Ten animals in each subgroup/local treatment were euthanized at 7, 15 and 30 days. Samples of gingival tissue were processed to analyze the tissue oxidative damage and radiographic analysis. Levels of oxidative stress were analyzed by the expressions of Tripeptideglutathione (TG), Malondialdehyde (MDA) and Carbonylated Proteins (CP). Results: The animals in S group had higher levels of TG and lower levels of MDA and CP compared with Veh group (p<0.05). Radiographically, in the intragroup analysis Veh and S, LLLT showed lower bone loss (BL) compared with NT and SRP, in all experimental periods (p<0.01). In addition, a lower BL was observed for the animals of Veh group treated with LLLT compared with treatment SRP in the S group, in all experimental periods. Conclusion: Within the limits of this study, we can conclude that LLLT was effective as adjuvant treatment for SRP protecting against the occurrence of oxidative tissue damages as well as for reducing alveolar bone loss in experimentally induced periodontitis simvastatin-modified rats.
[Mh] Termos MeSH primário: Raspagem Dentária/métodos
Inibidores de Hidroximetilglutaril-CoA Redutases/farmacologia
Lasers Semicondutores/uso terapêutico
Terapia com Luz de Baixa Intensidade/métodos
Periodontite/terapia
Sinvastatina/farmacologia
[Mh] Termos MeSH secundário: Animais
Gengiva/química
Gengiva/efeitos dos fármacos
Glutationa/análise
Masculino
Malondialdeído/análise
Mandíbula/diagnóstico por imagem
Periodontite/diagnóstico por imagem
Carbonilação Proteica
Radioterapia Adjuvante
Distribuição Aleatória
Ratos Wistar
Valores de Referência
Reprodutibilidade dos Testes
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors); 4Y8F71G49Q (Malondialdehyde); AGG2FN16EV (Simvastatin); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE


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[PMID]:28806114
[Au] Autor:Tóbiás Z; Pálinkó D; Sztanó B; Csanády M; Gál P; Rovó L
[Ad] Endereço:Fül-Orr-Gégészeti és Fej-Nyak Sebészeti Klinika, Szegedi Tudományegyetem, Általános Orvostudományi Kar Szeged.
[Ti] Título:[Endoscopic ultra dream pulse laser surgery of laryngomalacia. Our experiences gained during the introduction of the method in Hungary].
[Ti] Título:A laryngomalacia endoszkópos ultrapulzációs-lézeres (ultra dream pulse) sebészete. A módszer hazai bevezetése során szerzett tapasztalataink..
[So] Source:Orv Hetil;158(33):1288-1292, 2017 Aug.
[Is] ISSN:0030-6002
[Cp] País de publicação:Hungary
[La] Idioma:hun
[Ab] Resumo:INTRODUCTION: Congenital stridor and dyspnoe are caused by laryngomalacia in most cases. AIM: In this article we present a new, surgical method for treating severe laryngomalacia in patients under the age of 1, where ultrapulsated (UDP) laser beam is used for supraglottoplasty. Ultra dream pulse laser creates lesser thermical side damage in the tissue, therefore the risk of postoperative laryngeal oedema and scarring is lower. METHOD: We present 10 cases and the endoscopic UDP-laser surgery of patients under the age of 1 with severe laryngomalacia. RESULTS: After the surgery the stridorous symptoms disappeared, and there was no evidence of postoperative laryngeal oedema, there was no need for reoperation or tracheotomy in any of the cases. CONCLUSION: UDP-laser surgery of laryngomalacia is proven to be a safe and effective surgial modality. During the follow up visits we experienced neither recurrence of stridor nor laryngeal scarring. Orv Hetil. 2017; 158(33): 1288-1292.
[Mh] Termos MeSH primário: Endoscopia/métodos
Doenças da Laringe/cirurgia
Terapia com Luz de Baixa Intensidade/métodos
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Lactente
Recém-Nascido
Masculino
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170815
[St] Status:MEDLINE
[do] DOI:10.1556/650.2017.30722


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Bussadori, Sandra Kalil
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[PMID]:28789647
[Au] Autor:Salgueiro MDCC; Bortoletto CC; Horliana ACR; Mota ACC; Motta LJ; Motta PB; MesquitaFerrari RA; Fernandes KPS; Bussadori SK
[Ad] Endereço:Postgraduate program in Biophotonics Applied to Health Sciences, Nove de Julho University, Rua Vergueiro, 249 - Liberdade, São Paulo, SP, CEP 0154001, Brazil.
[Ti] Título:Evaluation of muscle activity, bite force and salivary cortisol in children with bruxism before and after low level laser applied to acupoints: study protocol for a randomised controlled trial.
[So] Source:BMC Complement Altern Med;17(1):391, 2017 Aug 08.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Bruxism is a repetitive activity that causes tooth wear, audible sounds, and discomfort. Preventive measures have been studied for conditions that can exert a negative influence on physiological development in children. Low-level laser therapy administered over acupoints is an effective, painless, low-cost treatment option that has achieved good results. Thus, the aim of the proposed study is to evaluate changes in muscle activity, bite force and salivary cortisol in children with bruxism after the application of low-level laser to accupoints. METHODS: The children will be randomly allocated to four groups of 19 individuals: G1 - low-level laser; G2 - occlusal splint; G3 - placebo laser; and G4 - control (without bruxism). The BTS TMJOINT electromyography will be used to determine muscle activity and a digital gnathodynamometer will be used to measure bite force. Salivary cortisol will be analysed at baseline as well as one and six months after treatment. Two-way ANOVA will be employed and complemented by Tukey's test. DISCUSSION: Bruxism is a repetitive activity of the masticatory muscles that can have negative consequences if not treated, such as tooth wear, noises, discomfort and anxiety. Thus, control and treatment measures should be taken. Although low-level laser therapy over acupoints has been indicated for children, the effects of this treatment modality have not yet been studied. TRIAL REGISTRATION: NCT02757261 on 8 April 2016. This study protocol received a grant from the Brazilian fostering agency São Paulo Research Foundation (FAPESP: #2015/24731-0).
[Mh] Termos MeSH primário: Pontos de Acupuntura
Força de Mordida
Bruxismo/terapia
Hidrocortisona/metabolismo
Terapia com Luz de Baixa Intensidade
Músculos da Mastigação/fisiologia
[Mh] Termos MeSH secundário: Bruxismo/metabolismo
Criança
Eletromiografia
Feminino
Seres Humanos
Masculino
Projetos de Pesquisa
Saliva/metabolismo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170810
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1905-y


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[PMID]:28772237
[Au] Autor:Trawitzki BF; Lilge L; de Figueiredo FAT; Macedo AP; Issa JPM
[Ad] Endereço:School of Dentistry of Ribeirao Preto, University of São Paulo, Brazil; Princess Margaret Cancer Centre, University Health Network, 101 College Street, Toronto, Canada; Department of Medical Biophysics, University of Toronto, 101 College Street, Toronto, Canada.
[Ti] Título:Low-intensity laser therapy efficacy evaluation in mice subjected to acute arthritis condition.
[So] Source:J Photochem Photobiol B;174:126-132, 2017 Sep.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Acute arthritis is an inflammation that affects many joints. The principal treatment options comprise drugs (corticosteroids), invasive and painful surgery. The objective of this study was to evaluate the efficacy of low intensity laser therapy (LILT), a non-invasive treatment, in a murine model of acute inflammation model. 48 mice received a synovial injection of Zymosan A into one knee. Mice were treated with LILT by three different wavelengths, either as a single (S) or dual (D) application immediately after the injury or after 24h following initiation of an inflammatory response. The histological analysis aimed at identifying inflammatory infiltrate and the structure of the articular surfaces as an indicator of a long-term damage due to inflammation. Statistical analysis (Kruskal-Wallis test), did not allow to reject the null hypothesis. However, LILT promoted histological alterations in some treatment groups. Histological evidence (Median and confidence interval) of anti-inflammatory effects was especially noticeable in knees of mice irradiated with lasers emitting moderate intensity and continuous 660nm (S=18.5 (11.4; 27.6); D=16.0 (6.93; 27.0)) and high intensity and pulsed 905nm (S=17.5 (10.2; 24.79), with decrease of the resorbed region. However, the 905nm pulsed laser was responsible for exacerbation of inflammation for multiple LILT sessions with a short delay (D=45.0 (22.84; 63.83)), tending to aggravate the resorption of the articular surface (p<0.05). LILT showed signs of an anti-inflammatory effect when applied once, but promoted increased resorptive area when used for two sessions, indicating the importance of a controlled LILT protocol to reach therapeutic effects.
[Mh] Termos MeSH primário: Artrite/radioterapia
Terapia com Luz de Baixa Intensidade
[Mh] Termos MeSH secundário: Doença Aguda
Animais
Artrite/induzido quimicamente
Artrite/metabolismo
Artrite/patologia
Lipopolissacarídeos/farmacologia
Masculino
Camundongos
Osteocalcina/metabolismo
Osteoprotegerina/metabolismo
Ligante RANK/metabolismo
Fosfatase Ácida Resistente a Tartarato/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lipopolysaccharides); 0 (Osteoprotegerin); 0 (RANK Ligand); 104982-03-8 (Osteocalcin); EC 3.1.3.2 (Acp5 protein, mouse); EC 3.1.3.2 (Tartrate-Resistant Acid Phosphatase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE



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