Base de dados : MEDLINE
Pesquisa : E02.642.249.220 [Categoria DeCS]
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[PMID]:28899845
[Au] Autor:Fuentes EN; Zuloaga R; Almarza O; Mendez K; Valdés JA; Molina A; Pulgar J
[Ad] Endereço:Interdisciplinary Center for Aquaculture Research (INCAR), Víctor Lamas 1290, PO Box 160-C, Concepción 4030000, Chile.
[Ti] Título:Upwelling-derived oceanographic conditions impact growth performance and growth-related gene expression in intertidal fish.
[So] Source:Comp Biochem Physiol B Biochem Mol Biol;214:12-18, 2017 Dec.
[Is] ISSN:1879-1107
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Growth is one of the main biological processes in aquatic organisms that is affected by environmental fluctuations such as upwelling (characterized by food-rich waters). In fish, growth is directly related with skeletal muscle increase; which represents the largest tissue of body mass. However, the effects of upwelling on growth, at the physiological and molecular level, are unknown. This study used Girella laevifrons (one of the most abundant intertidal fish in Eastern South Pacific) as a biological model, considering animals from upwelling (U) and non-upwelling (NU) areas. Here, we evaluated the effect of nutritional composition and food availability on growth performance and expression of key growth-related genes (insulin-kike growth factor 1 (igf1) and myosin heavy-chain (myhc)) and atrophy-related genes (muscle ring-finger 1 (murf1), F-box only protein 32 (atrogin-1) and BCL2/adenovirus E1B 19kDa-interacting protein 3 (bnip3)). We reported that, among zones, U fish displayed higher growth performance in response to nutritional composition, specifically between protein- and fiber-rich diets (~1g). We also found in NU fish that atrophy-related genes were upregulated with fiber-rich diet and during fasting (~2-fold at minimum respect U). In conclusion, our results suggest that the growth potential of upwelling fish may be a consequence of differential muscle gene expression. Our data provide a preliminary approach contributing on how upwelling influence fish growth at the physiological and molecular levels. Future studies are required to gain further knowledge about molecular differences between U and NU animals, as well as the possible applications of this knowledge in the aquaculture industry.
[Mh] Termos MeSH primário: Regulação da Expressão Gênica no Desenvolvimento
Proteínas Musculares/genética
Músculo Esquelético/metabolismo
Perciformes/crescimento & desenvolvimento
Perciformes/genética
[Mh] Termos MeSH secundário: Animais
Dieta da Carga de Carboidratos
Ecossistema
Cadeia Alimentar
Fator de Crescimento Insulin-Like I/genética
Fator de Crescimento Insulin-Like I/metabolismo
Proteínas Musculares/metabolismo
Músculo Esquelético/crescimento & desenvolvimento
Perciformes/metabolismo
Proteínas Proto-Oncogênicas/genética
Proteínas Proto-Oncogênicas/metabolismo
Rios/química
Proteínas Ligases SKP Culina F-Box/genética
Proteínas Ligases SKP Culina F-Box/metabolismo
Água do Mar/química
Proteínas com Motivo Tripartido/genética
Proteínas com Motivo Tripartido/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Muscle Proteins); 0 (Proto-Oncogene Proteins); 0 (Tripartite Motif Proteins); 67763-96-6 (Insulin-Like Growth Factor I); EC 2.3.2.27 (SKP Cullin F-Box Protein Ligases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170914
[St] Status:MEDLINE


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[PMID]:28571740
[Au] Autor:Wang J; Hu X; Ai W; Zhang F; Yang K; Wang L; Zhu X; Gao P; Shu G; Jiang Q; Wang S
[Ad] Endereço:Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, PR China; National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, PR China.
[Ti] Título:Phytol increases adipocyte number and glucose tolerance through activation of PI3K/Akt signaling pathway in mice fed high-fat and high-fructose diet.
[So] Source:Biochem Biophys Res Commun;489(4):432-438, 2017 Aug 05.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:It has been shown that adipose tissue hyperplasia (increased adipocyte number or adipogenesis) has beneficial effects on metabolic health. The aim of the present study was to determine whether phytol could modulate hyperplasia/adipogenesis and glucose homeostasis, and to explore the underlying mechanisms in mice fed high-fat and high fructose diet (HFFD). Our results demonstrated that phytol administration decreased body weight gain and inguinal subcutaneous white adipose tissue (iWAT) weight. However, phytol significantly increased the adipocyte number in iWAT, with the smaller average adipocyte diameter. Meanwhile, OGTT result showed that phytol improved glucose tolerance. In accord, phytol administration markedly increased expression of marker genes associated with adipogenesis (PPARγ and C/EBPα) and glucose uptake (AS160 and GLUT4) and activated PI3K/Akt signaling pathway in mice iWAT. In agreement with the in vivo findings, the in vitro results indicated that 100 µM phytol significantly enhanced 3T3-L1 adipogenesis and glucose uptake, and activated PI3K/Akt signaling pathway. However, phytol-induced enhancement of 3T3-L1 adipognesis and glucose uptake, activation of PI3K/Akt signaling pathway, elevation of marker genes involved in adipogensis and glucose uptake, as well as translocation of GLUT4 from cytoplasm to membrane were abolished by Wortmannin, a specific PI3K/Akt inhibitor. Taken together, phytol increased adipocyte number in iWAT and improved glucose tolerance in mice fed HFFD, which was coincident with the enhanced adipogenesis and glucose uptake in 3T3-L1, and was associated with activation of PI3K/Akt signaling pathway. These data suggested the application of phytol as a potential nutritional agent to combat obesity and type 2 diabetes.
[Mh] Termos MeSH primário: Adipócitos/efeitos dos fármacos
Dieta Hiperlipídica
Frutose/administração & dosagem
Fosfatidilinositol 3-Quinases/metabolismo
Fitol/farmacologia
Proteínas Proto-Oncogênicas c-akt/metabolismo
Transdução de Sinais/efeitos dos fármacos
[Mh] Termos MeSH secundário: Células 3T3-L1
Adipócitos/citologia
Androstadienos/farmacologia
Animais
Contagem de Células
Diferenciação Celular/efeitos dos fármacos
Células Cultivadas
Diabetes Mellitus Experimental
Dieta da Carga de Carboidratos/efeitos adversos
Dieta Hiperlipídica/efeitos adversos
Frutose/efeitos adversos
Teste de Tolerância a Glucose
Camundongos
Camundongos Endogâmicos C57BL
Fosfatidilinositol 3-Quinases/antagonistas & inibidores
Proteínas Proto-Oncogênicas c-akt/antagonistas & inibidores
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Androstadienes); 150-86-7 (Phytol); 30237-26-4 (Fructose); EC 2.7.1.- (Phosphatidylinositol 3-Kinases); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); XVA4O219QW (wortmannin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE


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[PMID]:28566287
[Au] Autor:Nakatsu Y; Mori K; Matsunaga Y; Yamamotoya T; Ueda K; Inoue Y; Mitsuzaki-Miyoshi K; Sakoda H; Fujishiro M; Yamaguchi S; Kushiyama A; Ono H; Ishihara H; Asano T
[Ad] Endereço:From the Department of Medical Science, Graduate School of Medicine, University of Hiroshima, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima 734-8551.
[Ti] Título:The prolyl isomerase Pin1 increases ß-cell proliferation and enhances insulin secretion.
[So] Source:J Biol Chem;292(28):11886-11895, 2017 Jul 14.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The prolyl isomerase Pin1 binds to the phosphorylated Ser/Thr-Pro motif of target proteins and enhances their cis-trans conversion. This report is the first to show that Pin1 expression in pancreatic ß cells is markedly elevated by high-fat diet feeding and in ob/ob mice. To elucidate the role of Pin1 in pancreatic ß cells, we generated ß-cell-specific Pin1 KO (ßPin1 KO) mice. These mutant mice showed exacerbation of glucose intolerance but had normal insulin sensitivity. We identified two independent factors underlying impaired insulin secretion in the ßPin1 KO mice. Pin1 enhanced pancreatic ß-cell proliferation, as indicated by a reduced ß-cell mass in ßPin1 KO mice compared with control mice. Moreover, a diet high in fat and sucrose failed to increase pancreatic ß-cell growth in the ßPin1 KO mice, an observation to which up-regulation of the cell cycle protein cyclin D appeared to contribute. The other role of Pin1 was to activate the insulin-secretory step: Pin1 KO ß cells showed impairments in glucose- and KCl-induced elevation of the intracellular Ca concentration and insulin secretion. We also identified salt-inducible kinase 2 (SIK2) as a Pin1-binding protein that affected the regulation of Ca influx and found Pin1 to enhance SIK2 kinase activity, resulting in a decrease in p35 protein, a negative regulator of Ca influx. Taken together, our observations demonstrate critical roles of Pin1 in pancreatic ß cells and that Pin1 both promotes ß-cell proliferation and activates insulin secretion.
[Mh] Termos MeSH primário: Indução Enzimática
Células Secretoras de Insulina/enzimologia
Insulina/secreção
Peptidilprolil Isomerase de Interação com NIMA/metabolismo
Obesidade/metabolismo
Proteínas Serina-Treonina Quinases/metabolismo
[Mh] Termos MeSH secundário: Substituição de Aminoácidos
Animais
Sítios de Ligação
Sinalização do Cálcio
Linhagem Celular
Proliferação Celular
Dieta da Carga de Carboidratos/efeitos adversos
Dieta Hiperlipídica/efeitos adversos
Seres Humanos
Células Secretoras de Insulina/citologia
Células Secretoras de Insulina/secreção
Camundongos Knockout
Camundongos Mutantes
Camundongos Transgênicos
Mutação
Peptidilprolil Isomerase de Interação com NIMA/antagonistas & inibidores
Peptidilprolil Isomerase de Interação com NIMA/química
Peptidilprolil Isomerase de Interação com NIMA/genética
Obesidade/etiologia
Obesidade/patologia
Proteínas Serina-Treonina Quinases/química
Proteínas Serina-Treonina Quinases/genética
Interferência de RNA
Proteínas Recombinantes de Fusão/química
Proteínas Recombinantes de Fusão/genética
Proteínas Recombinantes de Fusão/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insulin); 0 (NIMA-Interacting Peptidylprolyl Isomerase); 0 (Recombinant Fusion Proteins); EC 2.7.1.- (salt-inducible kinase-2, mouse); EC 2.7.11.1 (Protein-Serine-Threonine Kinases); EC 5.2.1.8 (PIN1 protein, human); EC 5.2.1.8 (Pin1 protein, mouse)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170803
[Lr] Data última revisão:
170803
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M117.780726


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[PMID]:28406435
[Au] Autor:Biggelaar LJ; Eussen SJ; Sep SJ; Mari A; Ferrannini E; Dongen MC; Denissen KF; Wijckmans NE; Schram MT; Kallen CJ; Koster A; Schaper N; Henry RM; Stehouwer CD; Dagnelie PC
[Ad] Endereço:Department of Epidemiology, Maastricht University, Maastricht MD 6200, The Netherlands. louise.denbiggelaar@maastrichtuniversity.nl.
[Ti] Título:Associations of Dietary Glucose, Fructose, and Sucrose with ß-Cell Function, Insulin Sensitivity, and Type 2 Diabetes in the Maastricht Study.
[So] Source:Nutrients;9(4), 2017 Apr 13.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The associations of glucose, fructose, and sucrose intake with type 2 diabetes mellitus (T2DM) have been inconsistent. Furthermore, there is a lack of studies focusing on early markers of T2DM that provide insight into the process of T2DM progression: impaired pancreatic ß-cell function (BCF) and insulin sensitivity. This study evaluated associations cross-sectionally in a population-based cohort consisting of 2818 individuals (mean ± SD age 59.7 ± 8.18, 49.5% male, = 120 newly diagnosed T2DM). Glucose, fructose, and sucrose intake were assessed by a food frequency questionnaire. Glucose metabolism status, insulin sensitivity, and BCF were measured by a seven-points oral glucose tolerance test. Linear regression analysis revealed a positive association of glucose intake with insulin sensitivity in the fully adjusted model (standardized beta (95% CI) 0.07 (0.05, 0.14) SD for ≥23 g vs. <10 g of glucose). Fructose and sucrose intake were not associated with insulin sensitivity after full adjustments. In addition, no associations of dietary glucose, fructose, and sucrose with BCF were detected. In conclusion, higher intake of glucose, not fructose and sucrose, was associated with higher insulin sensitivity, independent of dietary fibre. No convincing evidence was found for associations of dietary glucose, fructose, and sucrose with BCF in this middle-aged population.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/etiologia
Dieta da Carga de Carboidratos/efeitos adversos
Glucose/efeitos adversos
Resistência à Insulina
Células Secretoras de Insulina/secreção
Insulina/secreção
Estado Pré-Diabético/etiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Biomarcadores/sangue
Estudos de Coortes
Estudos Transversais
Diabetes Mellitus Tipo 2/epidemiologia
Diabetes Mellitus Tipo 2/etnologia
Diabetes Mellitus Tipo 2/metabolismo
Dieta da Carga de Carboidratos/etnologia
Sacarose na Dieta/efeitos adversos
Feminino
Frutose/efeitos adversos
Seres Humanos
Insulina/sangue
Resistência à Insulina/etnologia
Masculino
Meia-Idade
Países Baixos/epidemiologia
Inquéritos Nutricionais
Estado Pré-Diabético/epidemiologia
Estado Pré-Diabético/etnologia
Estado Pré-Diabético/metabolismo
Prevalência
Estudos Prospectivos
Autorrelato
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Biomarkers); 0 (Dietary Sucrose); 0 (Insulin); 30237-26-4 (Fructose); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE


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[PMID]:28398243
[Au] Autor:Tran NT; Alexandre-Gouabau MC; Pagniez A; Ouguerram K; Boquien CY; Winer N; Darmaun D
[Ad] Endereço:INRA, UMR 1280, Physiology of Nutritional Adaptations, University of Nantes, IMAD and CRNH-Ouest, Nantes 44000, France. thang.tranobs@gmail.com.
[Ti] Título:Neonatal Citrulline Supplementation and Later Exposure to a High Fructose Diet in Rats Born with a Low Birth Weight: A Preliminary Report.
[So] Source:Nutrients;9(4), 2017 Apr 11.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:A low birth weight (LBW) leads to a higher risk of metabolic syndrome in adulthood. Literature suggests that citrulline supplementation in adulthood prevents the effect of a high fructose diet on energy metabolism. Whether neonatal citrulline supplementation would alter early growth or energy metabolism in the long-term in rats with LBW is unknown. LBW pups born from dams fed a low (4%) protein diet, were nursed by normally-fed dams and received isonitrogenous supplements of either l-citrulline or l-alanine by gavage from the sixth day of life until weaning, and were subsequently exposed to 10%-fructose in drinking water from weaning to 90 days of age. The oral glucose tolerance was tested (OGTT) at 70 days of age, and rats were sacrificed at 90 days of age. Pre-weaning citrulline supplementation failed to alter the growth trajectory, OGTT, plasma triglycerides, or fat mass accretion in adulthood; yet, it was associated with increased liver triglycerides, decreased liver total cholesterol, and a distinct liver lipidomic profile that may result in a predisposition to liver disease. We conclude that pre-weaning supplementation with citrulline does not impact early growth, but might impact liver fat metabolism in adulthood upon exposure to a high fructose diet.
[Mh] Termos MeSH primário: Citrulina/efeitos adversos
Suplementos Nutricionais
Retardo do Crescimento Fetal/fisiopatologia
Insuficiência Hepática/etiologia
Metabolismo dos Lipídeos
Fígado/metabolismo
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Peso ao Nascer
Citrulina/uso terapêutico
Dieta da Carga de Carboidratos/efeitos adversos
Dieta com Restrição de Proteínas/efeitos adversos
Suplementos Nutricionais/efeitos adversos
Feminino
Retardo do Crescimento Fetal/etiologia
Retardo do Crescimento Fetal/metabolismo
Frutose/efeitos adversos
Insuficiência Hepática/metabolismo
Insuficiência Hepática/fisiopatologia
Lactação
Fígado/fisiopatologia
Masculino
Fenômenos Fisiológicos da Nutrição Materna
Síndrome Metabólica/etiologia
Síndrome Metabólica/prevenção & controle
Projetos Piloto
Gravidez
Distribuição Aleatória
Ratos Sprague-Dawley
Desmame
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
29VT07BGDA (Citrulline); 30237-26-4 (Fructose)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE


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[PMID]:28393204
[Au] Autor:Takahashi M; Inoue T; Huang M; Numakura K; Tsuruta H; Saito M; Maeno A; Nakamura E; Narita S; Tsuchiya N; Habuchi T
[Ad] Endereço:Department of Urology, Akita University Graduate School of Medicine, Akita, Japan.
[Ti] Título:Inverse relationship between insulin receptor expression and progression in renal cell carcinoma.
[So] Source:Oncol Rep;37(5):2929-2941, 2017 May.
[Is] ISSN:1791-2431
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:We investigated the relationship among serum insulin level, insulin receptor (IR) expression in renal cell carcinoma (RCC), and outcomes in patients with RCC who underwent nephrectomy. We also explored the role of insulin signaling in RCC progression in a murine RCC allograft RENCA model using metformin to treat hyperinsulinemia induced by a high-carbohydrate diet. Clinically, the IR expression level in RCC tissue was significantly lower in patients with tumor stage pT2-4 and/or distant metastases. The IR expression level in RCC tissue was significantly lower in patients with preoperative serum C-peptide levels greater than or equal to the median than in patients with levels less than the median. High IR expression level was significantly associated with better disease-free and overall survival after nephrectomy. The IR expression level was significantly higher in murine subcutaneous flank tumors of the low-carbohydrate diet group and high-carbohydrate diet plus metformin group than of the high­carbohydrate diet group. In vivo progression of murine tumors was not significantly enhanced by hyperinsulinemia induced by a high-carbohydrate diet and was significantly inhibited by metformin in both the low- and high­carbohydrate diet groups. IR expression in RCC tissue was inversely associated with cancer progression in the clinical and murine experimental model studies. The clinical and murine allograft model study results suggested that hyperinsulinemia does not promote RCC progression. Decreased IR expression in high­stage RCC tumors with poor prognosis may be the result of downregulation induced by the host's hyperinsulinemia.
[Mh] Termos MeSH primário: Antígenos CD/metabolismo
Carcinoma de Células Renais/cirurgia
Dieta da Carga de Carboidratos/efeitos adversos
Hiperinsulinismo/tratamento farmacológico
Insulina/sangue
Neoplasias Renais/cirurgia
Metformina/administração & dosagem
Receptor de Insulina/metabolismo
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Animais
Carcinoma de Células Renais/tratamento farmacológico
Carcinoma de Células Renais/metabolismo
Progressão da Doença
Feminino
Seres Humanos
Hiperinsulinismo/induzido quimicamente
Hiperinsulinismo/metabolismo
Neoplasias Renais/tratamento farmacológico
Neoplasias Renais/metabolismo
Masculino
Metformina/uso terapêutico
Camundongos
Meia-Idade
Transplante de Neoplasias
Análise de Sobrevida
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD); 0 (Insulin); 9100L32L2N (Metformin); EC 2.7.10.1 (INSR protein, human); EC 2.7.10.1 (Receptor, Insulin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170411
[St] Status:MEDLINE
[do] DOI:10.3892/or.2017.5552


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[PMID]:28338608
[Au] Autor:Jung CH; Choi KM
[Ad] Endereço:Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University School of Medicine, Bucheon Hospital, 170 Jomaru-Ro, Wonmi-Gu, Bucheon-Si, Gyeonggi-Do 420-767, Korea. chanh@schmc.ac.kr.
[Ti] Título:Impact of High-Carbohydrate Diet on Metabolic Parameters in Patients with Type 2 Diabetes.
[So] Source:Nutrients;9(4), 2017 Mar 24.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:In patients with type 2 diabetes mellitus (T2DM), whether dietary carbohydrates have beneficial or detrimental effects on cardiometabolic risk factors has drawn attention. Although a high-carbohydrate (HC) diet and a low-carbohydrate (LC) diet have gained popularity for several decades, there is scarce review focusing on the effects of HC diet on glucose, lipids and body weight in patients with T2DM. In this review, we examined recently-published literature on the effects of HC diets on metabolic parameters in T2DM. HC diets are at least as effective as LC diets, leading to significant weight loss and a reduction in plasma glucose, HbA1c and low density lipoprotein-cholesterol (LDL-C) levels. The major concern is that HC diets may raise serum triglyceride levels and reduce high density lipoprotein-cholesterol (HDL-C) levels, increasing the risk of cardiovascular disease. However, these untoward effects were not a persistent consequence and may be ameliorated with the consumption of a low glycemic index (GI)/low glycemic load (GL) and high fiber. Carbohydrate intake should be individualized, and low caloric intake remains a crucial factor to improve insulin sensitivity and reduce body weight; however, an HC diet, rich in fiber and with a low GI/GL, may be recommendable in patients with T2DM.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/dietoterapia
Dieta da Carga de Carboidratos
Carboidratos da Dieta/administração & dosagem
[Mh] Termos MeSH secundário: Glicemia/metabolismo
Peso Corporal
HDL-Colesterol/sangue
LDL-Colesterol/sangue
Dieta com Restrição de Carboidratos
Fibras na Dieta/administração & dosagem
Hemoglobina A Glicada/metabolismo
Índice Glicêmico
Carga Glicêmica
Seres Humanos
Resistência à Insulina
Ensaios Clínicos Controlados Aleatórios como Assunto
Triglicerídeos/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Cholesterol, HDL); 0 (Cholesterol, LDL); 0 (Dietary Carbohydrates); 0 (Dietary Fiber); 0 (Glycated Hemoglobin A); 0 (Triglycerides)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE


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[PMID]:28199417
[Au] Autor:Barbosa de Queiroz K; Honorato-Sampaio K; Rossoni Júnior JV; Andrade Leal D; Pinto AB; Kappes-Becker L; Evangelista EA; Guerra-Sá R
[Ad] Endereço:Laboratório de Bioquímica e Biologia Molecular, Núcleo de Pesquisas em Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brasil.
[Ti] Título:Physical activity prevents alterations in mitochondrial ultrastructure and glucometabolic parameters in a high-sugar diet model.
[So] Source:PLoS One;12(2):e0172103, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Endurance exercise is a remarkable intervention for the treatment of many diseases. Mitochondrial changes on skeletal muscle are likely important for many of the benefits provided by exercise. In this study, we aimed to evaluate the effects that a regular physical activity (swimming without workload) has on mitochondrial morphological alterations and glucometabolic parameters induced by a high-sugar diet (HSD). Weaned male Wistar rats fed with a standard diet or a HSD (68% carbohydrate) were subjected to 60 minutes of regular physical activity by swimming (without workload) for four- (20 sessions) or eight-week (40 sessions) periods. After training, animals were euthanized and the sera, adipose tissues, and skeletal muscles were collected for further analysis. The HSD increased body weight after an 8-week period; it also increased the fat pads and the adipose index, resulting in glucose intolerance and insulin resistance (IR). Transmission electron microscopy showed an increase in alterations of mitochondrial ultrastructure in the gastrocnemius muscle, as well as a decrease in superoxide dismutase (SOD) activity, and an increase in protein carbonylation. Regular physical activity partially reverted these alterations in rats fed a HSD, preventing mitochondrial morphological alterations and IR. Moreover, we observed a decrease in Pgc1α expression (qPCR analysis) in STD-EXE group and a less pronounced reduction in HSD-EXE group after an 8-week period. Thus, regular physical activity (swimming without workload) in rats fed a HSD can prevent mitochondrial dysfunction and IR, highlighting the crucial role for physical activity on metabolic homeostasis.
[Mh] Termos MeSH primário: Dieta da Carga de Carboidratos
Glucose/metabolismo
Mitocôndrias/ultraestrutura
[Mh] Termos MeSH secundário: Tecido Adiposo/metabolismo
Animais
Glicemia/análise
Citrato (si)-Sintase/metabolismo
Teste de Tolerância a Glucose
Insulina/sangue
Resistência à Insulina
Masculino
Microscopia Eletrônica de Transmissão
Mitocôndrias/metabolismo
Músculo Esquelético/metabolismo
Estresse Oxidativo
Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/genética
Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/metabolismo
Condicionamento Físico Animal
Carbonilação Proteica
Ratos
Ratos Wistar
Superóxido Dismutase/metabolismo
Natação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Insulin); 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha); 0 (Ppargc1a protein, rat); EC 1.15.1.1 (Superoxide Dismutase); EC 2.3.3.1 (Citrate (si)-Synthase); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170216
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0172103


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[PMID]:28157387
[Au] Autor:Afifi NA; Ramadan A; Erian EY; Saleh DO; Sedik AA; Badawi M; El Hotaby W
[Ad] Endereço:a Pharmacology Department, Faculty of Veterinary Medicine, Cairo University.
[Ti] Título:Trigonelline attenuates hepatic complications and molecular alterations in high-fat high-fructose diet-induced insulin resistance in rats.
[So] Source:Can J Physiol Pharmacol;95(4):427-436, 2017 Apr.
[Is] ISSN:1205-7541
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:The present study aimed to evaluate the effect of trigonelline (TRG) on the hepatic complications associated with high-fat high-fructose (HFHF) diet-induced insulin resistance (IR) in rats. IR was induced by giving a saturated fat diet and 10% fructose in drinking water to rats for 8 weeks. Insulin-resistant rats were orally treated with TRG (50 and 100 mg/kg), sitagliptin (SIT; 5 mg/kg), or a combination of TRG (50 mg/kg) and SIT (5 mg/kg) for 14 days. Liver homogenates were used for assessment of hepatic lipids, oxidative stress biomarkers, and inflammatory cytokines. Histopathological and DNA cytometry examinations were carried out for hepatic and pancreatic tissues. Hepatic tissues were examined using Fourier-transform infrared spectroscopy for assessment of any molecular changes. Results of the present study revealed that oral treatment of insulin-resistant rats with TRG or TRG in combination with SIT significantly decreased homeostatic model assessment of IR, hepatic lipids, oxidative stress biomarkers, and the inflammatory cytokines. TRG or TRG in combination with SIT ameliorated the histopathological, DNA cytometry, and molecular alterations induced by a HFHF diet. Finally, it can be concluded that TRG has beneficial effects on the hepatic complications associated with IR due to its hypoglycemic effect and antioxidant potential.
[Mh] Termos MeSH primário: Alcaloides/uso terapêutico
Antioxidantes/uso terapêutico
Hipoglicemiantes/uso terapêutico
Síndrome Metabólica/complicações
Hepatopatia Gordurosa não Alcoólica/tratamento farmacológico
Fosfato de Sitagliptina/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Biomarcadores/análise
Glicemia/análise
Citocinas/análise
Dieta da Carga de Carboidratos/efeitos adversos
Dieta Hiperlipídica/efeitos adversos
Inibidores da Dipeptidil Peptidase IV/uso terapêutico
Modelos Animais de Doenças
Avaliação Pré-Clínica de Medicamentos
Quimioterapia Combinada
Seres Humanos
Lipídeos/análise
Fígado/efeitos dos fármacos
Fígado/metabolismo
Fígado/patologia
Masculino
Síndrome Metabólica/etiologia
Hepatopatia Gordurosa não Alcoólica/etiologia
Estresse Oxidativo/efeitos dos fármacos
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Antioxidants); 0 (Biomarkers); 0 (Blood Glucose); 0 (Cytokines); 0 (Dipeptidyl-Peptidase IV Inhibitors); 0 (Hypoglycemic Agents); 0 (Lipids); 3NQ9N60I00 (trigonelline); TS63EW8X6F (Sitagliptin Phosphate)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170204
[St] Status:MEDLINE
[do] DOI:10.1139/cjpp-2016-0269


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[PMID]:28067763
[Au] Autor:Tierney M; Gallagher AM; Giotis ES; Pentieva K
[Ad] Endereço:School of Biomedical Sciences, Ulster University, Coleraine BT52 1SA, UK. tierney_mary@hotmail.com.
[Ti] Título:An Online Survey on Consumer Knowledge and Understanding of Added Sugars.
[So] Source:Nutrients;9(1), 2017 Jan 05.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Evidence of an association between added sugars (AS) and the risk of obesity has triggered public health bodies to develop strategies enabling consumers to manage their AS intake. The World Health Organisation (WHO) has strongly recommended a reduction of free sugars to 10% of total dietary energy (TE) and conditionally recommended a reduction to 5% TE to achieve health benefits. Despite food labelling being a policy tool of choice in many countries, there is no consensus on the mandatory addition of AS to the nutrition panel of food labels. An online survey was conducted to explore consumer ability to identify AS on food labels and to investigate consumer awareness of the WHO guidelines in relation to sugar intakes. The questionnaire was tested for participant comprehension using face-to-face interviews prior to conducting the online study. The online survey was conducted in Northern Ireland during May 2015 and was completed by a convenient sample of 445 subjects. Results showed that just 4% of respondents correctly classified 10 or more ingredients from a presented list of 13 items, while 65% of participants were unaware of the WHO guidelines for sugar intake. It may be timely to reopen dialogue on inclusion of AS on food product nutrition panels.
[Mh] Termos MeSH primário: Dieta da Carga de Carboidratos/efeitos adversos
Conhecimentos, Atitudes e Prática em Saúde
Adoçantes não Calóricos/efeitos adversos
Adoçantes Calóricos/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Comportamento do Consumidor
Informação de Saúde ao Consumidor
Cárie Dentária/epidemiologia
Cárie Dentária/etiologia
Cárie Dentária/prevenção & controle
Dieta com Restrição de Carboidratos
Feminino
Rotulagem de Alimentos
Seres Humanos
Internet
Masculino
Irlanda do Norte/epidemiologia
Política Nutricional
Inquéritos Nutricionais
Obesidade/epidemiologia
Obesidade/etiologia
Obesidade/prevenção & controle
Cooperação do Paciente
Risco
Reino Unido/epidemiologia
Organização Mundial da Saúde
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Non-Nutritive Sweeteners); 0 (Nutritive Sweeteners)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170110
[St] Status:MEDLINE



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