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[PMID]:29283995
[Au] Autor:Rossi M; Caruso F; Kwok L; Lee G; Caruso A; Gionfra F; Candelotti E; Belli SL; Molasky N; Raley-Susman KM; Leone S; Filipský T; Tofani D; Pedersen J; Incerpi S
[Ad] Endereço:Vassar College, Department of Chemistry, Poughkeepsie, NY, United States of America.
[Ti] Título:Protection by extra virgin olive oil against oxidative stress in vitro and in vivo. Chemical and biological studies on the health benefits due to a major component of the Mediterranean diet.
[So] Source:PLoS One;12(12):e0189341, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We report the results of in vivo studies in Caenorhabditis elegans nematodes in which addition of extra virgin olive oil (EVOO) to their diet significantly increased their life span with respect to the control group. Furthermore, when nematodes were exposed to the pesticide paraquat, they started to die after two days, but after the addition of EVOO to their diet, both survival percentage and lifespans of paraquat-exposed nematodes increased. Since paraquat is associated with superoxide radical production, a test for scavenging this radical was performed using cyclovoltammetry and the EVOO efficiently scavenged the superoxide. Thus, a linear correlation (y = -0.0838x +19.73, regression factor = 0.99348) was observed for superoxide presence (y) in the voltaic cell as a function of aliquot (x) additions of EVOO, 10 µL each. The originally generated supoeroxide was approximately halved after 10 aliquots (100 µL total). The superoxide scavenging ability was analyzed, theoretically, using Density Functional Theory for tyrosol and hydroxytyrosol, two components of EVOO and was also confirmed experimentally for the galvinoxyl radical, using Electron Paramagnetic Resonance (EPR) spectroscopy. The galvinoxyl signal disappeared after adding 1 µL of EVOO to the EPR cell in 10 minutes. In addition, EVOO significantly decreased the proliferation of human leukemic THP-1 cells, while it kept the proliferation at about normal levels in rat L6 myoblasts, a non-tumoral skeletal muscle cell line. The protection due to EVOO was also assessed in L6 cells and THP-1 exposed to the radical generator cumene hydroperoxide, in which cell viability was reduced. Also in this case the oxidative stress was ameliorated by EVOO, in line with results obtained with tetrazolium dye reduction assays, cell cycle analysis and reactive oxygen species measurements. We ascribe these beneficial effects to EVOO antioxidant properties and our results are in agreement with a clear health benefit of EVOO use in the Mediterranean diet.
[Mh] Termos MeSH primário: Dieta Mediterrânea
Azeite de Oliva/farmacologia
Estresse Oxidativo/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Caenorhabditis elegans/efeitos dos fármacos
Caenorhabditis elegans/metabolismo
Ciclo Celular/efeitos dos fármacos
Linhagem Celular
Espectroscopia de Ressonância de Spin Eletrônica
Seres Humanos
Técnicas In Vitro
Azeite de Oliva/química
Paraquat/toxicidade
Ratos
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Olive Oil); 0 (Reactive Oxygen Species); PLG39H7695 (Paraquat)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189341


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[PMID]:29084532
[Au] Autor:Alonso-Molero J; González-Donquiles C; Palazuelos C; Fernández-Villa T; Ramos E; Pollán M; Aragonés N; Llorca J; Henar Alonso M; Tardón A; Amiano P; Moleon JJJ; Pérez RP; Capelo R; Molina AJ; Acebo IG; Guevara M; Gómez BP; Lope V; Huerta JM; Castaño-Vinyals G; Kogevinas M; Moreno V; Martín V
[Ad] Endereço:Grupo de Investigación en Interacciones Gen-Ambiente y Salud. Instituto de Biomedicina (IBIOMED), Universidad de León, León, Spain.
[Ti] Título:The RS4939827 polymorphism in the SMAD7 GENE and its association with Mediterranean diet in colorectal carcinogenesis.
[So] Source:BMC Med Genet;18(1):122, 2017 Oct 30.
[Is] ISSN:1471-2350
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The objective of our investigation is to study the relationship between the rs4939827 SNP in the SMAD7 gene, Mediterranean diet pattern and the risk of colorectal cancer. METHODS: We examined 1087 cases of colorectal cancer and 2409 population controls with available DNA samples from the MCC-Spain study, 2008-2012. Descriptive statistical analyses, and multivariate logistic mixed models were performed. The potential synergistic effect of rs4939827 and the Mediterranean diet pattern was evaluated with logistic regression in different strata of of adherence to the Mediterranean diet and the genotype. RESULTS: High adherence to Mediterrenean diet was statistically significantly associated with colorectal cancer risk. A decreased risk for CRC cancer was observed for the CC compared to the TT genotype (OR = 0.65 and 95% CI = 0.51-0.81) of the rs4939827 SNP Also, we could show an association between the Mediterranean diet pattern (protective factor) and rs4939827. Although the decreased risk for the CC genotype was slightly more pronounced in subjects with high adherence to Mediterrenean diet, there was no statistically significant synergistic effect between genotype CC and adherence to the Mediterranean dietary pattern factors. CONCLUSION: The SMAD7 gene and specifically the allele C could be protective for colorectal cancer. An independent protective association was also observed between high adherence Mediterranean diet pattern and CRC risk. Findings form this study indicate that high adherence to Mediterranean diet pattern has a protective role for CRC cancer probably involving the Tumor Growth Factor- ß pathway in this cancer.
[Mh] Termos MeSH primário: Carcinogênese/genética
Neoplasias Colorretais/genética
Neoplasias Colorretais/prevenção & controle
Dieta Mediterrânea
Interação Gene-Ambiente
Polimorfismo de Nucleotídeo Único
Proteína Smad7/genética
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Estudos de Casos e Controles
Neoplasias Colorretais/epidemiologia
Neoplasias Colorretais/patologia
Dieta Mediterrânea/estatística & dados numéricos
Feminino
Estudos de Associação Genética
Predisposição Genética para Doença
Genótipo
Seres Humanos
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (SMAD7 protein, human); 0 (Smad7 Protein)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171101
[St] Status:MEDLINE
[do] DOI:10.1186/s12881-017-0485-5


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[PMID]:29049303
[Au] Autor:Assaf-Balut C; García de la Torre N; Durán A; Fuentes M; Bordiú E; Del Valle L; Familiar C; Ortolá A; Jiménez I; Herraiz MA; Izquierdo N; Perez N; Torrejon MJ; Ortega MI; Illana FJ; Runkle I; de Miguel MP; Montañez C; Barabash A; Cuesta M; Rubio MA; Calle-Pascual AL
[Ad] Endereço:Endocrinology and Nutrition Department, Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.
[Ti] Título:A Mediterranean diet with additional extra virgin olive oil and pistachios reduces the incidence of gestational diabetes mellitus (GDM): A randomized controlled trial: The St. Carlos GDM prevention study.
[So] Source:PLoS One;12(10):e0185873, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Gestational diabetes mellitus (GDM) prevalence is increasing and becoming a major public health concern. Whether a Mediterranean diet can help prevent GDM in unselected pregnant women has yet to be studied. METHODS: We conducted a prospective, randomized controlled trial to evaluate the incidence of GDM with two different dietary models. All consecutive normoglycemic (<92 mg/dL) pregnant women at 8-12 gestational weeks (GW) were assigned to Intervention Group (IG, n = 500): MedDiet supplemented with extra virgin olive oil (EVOO) and pistachios; or Control Group (CG, n = 500): standard diet with limited fat intake. Primary outcome was to assess the effect of the intervention on GDM incidence at 24-28 GW. Gestational weight gain (GWG), pregnancy-induced hypertension, caesarean section (CS), preterm delivery, perineal trauma, small and large for gestational age (SGA and LGA) and admissions to neonatal intensive care unit were also assessed. Analysis was by intention-to-treat. RESULTS: A total of 874 women completed the study (440/434, CG/IG). According to nutritional questionnaires and biomarker analysis, women in the IG had a good adherence to the intervention. 177/874 women were diagnosed with GDM, 103/440 (23.4%) in CG and 74/434(17.1%) in IG, p = 0.012. The crude relative risk (RR) for GDM was 0.73 (95% CI: 0.56-0.95; p = 0.020) IG vs CG and persisted after adjusted multivariable analysis, 0.75(95% CI: 0.57-0.98; p = 0.039). IG had also significantly reduced rates of insulin-treated GDM, prematurity, GWG at 24-28 and 36-38 GW, emergency CS, perineal trauma, and SGA and LGA newborns (all p<0.05). CONCLUSIONS: An early nutritional intervention with a supplemented MedDiet reduces the incidence of GDM and improves several maternal and neonatal outcomes.
[Mh] Termos MeSH primário: Diabetes Gestacional/dietoterapia
Dieta Mediterrânea
Azeite de Oliva/administração & dosagem
Pistacia
[Mh] Termos MeSH secundário: Adulto
Diabetes Gestacional/epidemiologia
Feminino
Seres Humanos
Incidência
Recém-Nascido
Estilo de Vida
Gravidez
Resultado da Gravidez
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Olive Oil)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185873


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[PMID]:28967596
[Au] Autor:Bonaccio M; Ruggiero E; Di Castelnuovo A; Costanzo S; Persichillo M; De Curtis A; Cerletti C; Donati MB; de Gaetano G; Iacoviello L; Moli-sani study Investigators
[Ad] Endereço:Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo NEUROMED, 86077 Pozzilli, IS, Italy. Electronic address: marialaura.bonaccio@neuromed.it.
[Ti] Título:Fish intake is associated with lower cardiovascular risk in a Mediterranean population: Prospective results from the Moli-sani study.
[So] Source:Nutr Metab Cardiovasc Dis;27(10):865-873, 2017 Oct.
[Is] ISSN:1590-3729
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIMS: Fish consumption reportedly reduces the risk of heart disease, but the evidence of cardiovascular advantages associated with fish intake within Mediterranean cohorts is limited. The aim of this study was to test the association between fish intake and risk of composite coronary heart disease (CHD) and stroke in a large population-based cohort adhering to Mediterranean Diet. METHODS AND RESULTS: Prospective analysis on 20,969 subjects free from cardiovascular disease at baseline, enrolled in the Moli-sani study (2005-2010). Food intake was recorded by the Italian version of the EPIC food frequency questionnaire. Hazard ratios were calculated by using multivariable Cox-proportional hazard models. During a median follow-up of 4.3 years, a total of 352 events occurred (n of CHD = 287 and n of stroke = 66). After adjustment for a large panel of covariates, fish intake ≥4 times per week was associated with 40% reduced risk of composite CHD and stroke (HR = 0.60; 95%CI 0.40-0.90), and with 40% lower risk of CHD (HR = 0.60; 95%CI 0.38-0.94) as compared with subjects in the lowest category of intake (<2 times/week). A similar trend of protection was found for stroke risk although results were not significant (HR = 0.62; 95%CI 0.26-1.51). When fish types were considered, protection against the composite outcome and CHD was confined to fatty fish intake. CONCLUSIONS: Fish intake was associated with reduced risk of composite fatal and non-fatal CHD and stroke in a general Mediterranean population. The favourable association was likely to be driven by fatty fish.
[Mh] Termos MeSH primário: Doença das Coronárias/prevenção & controle
Dieta Mediterrânea
Gorduras na Dieta/administração & dosagem
Peixes
Dieta Saudável
Alimentos Marinhos
Acidente Vascular Cerebral/prevenção & controle
[Mh] Termos MeSH secundário: Adulto
Idoso
Animais
Doença das Coronárias/diagnóstico
Doença das Coronárias/epidemiologia
Comportamento Alimentar
Feminino
Seres Humanos
Itália/epidemiologia
Masculino
Meia-Idade
Análise Multivariada
Modelos de Riscos Proporcionais
Estudos Prospectivos
Fatores de Proteção
Fatores de Risco
Acidente Vascular Cerebral/diagnóstico
Acidente Vascular Cerebral/epidemiologia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Fats)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171003
[St] Status:MEDLINE


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[PMID]:28880991
[Au] Autor:Zalvan CH; Hu S; Greenberg B; Geliebter J
[Ad] Endereço:Department of Otolaryngology, New York Medical College, Valhalla.
[Ti] Título:A Comparison of Alkaline Water and Mediterranean Diet vs Proton Pump Inhibition for Treatment of Laryngopharyngeal Reflux.
[So] Source:JAMA Otolaryngol Head Neck Surg;143(10):1023-1029, 2017 Oct 01.
[Is] ISSN:2168-619X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: Laryngopharyngeal reflux (LPR) is a common disorder with protean manifestations in the head and neck. In this retrospective study, we report the efficacy of a wholly dietary approach using alkaline water, a plant-based, Mediterranean-style diet, and standard reflux precautions compared with that of the traditional treatment approach of proton pump inhibition (PPI) and standard reflux precautions. Objective: To determine whether treatment with a diet-based approach with standard reflux precautions alone can improve symptoms of LPR compared with treatment with PPI and standard reflux precautions. Design, Setting, and Participants: This was a retrospective medical chart review of 2 treatment cohorts. From 2010 to 2012, 85 patients with LPR that were treated with PPI and standard reflux precautions (PS) were identified. From 2013 to 2015, 99 patients treated with alkaline water (pH >8.0), 90% plant-based, Mediterranean-style diet, and standard reflux precautions (AMS) were identified. The outcome was based on change in Reflux Symptom Index (RSI). Main Outcomes and Measures: Recorded change in the RSI after 6 weeks of treatment. Results: Of the 184 patients identified in the PS and AMS cohorts, the median age of participants in each cohort was 60 years (95% CI, 18-82) and 57 years (95% CI, 18-93), respectively (47 [56.3%] and 61 [61.7%] were women, respectively). The percentage of patients achieving a clinically meaningful (≥6 points) reduction in RSI was 54.1% in PS-treated patients and 62.6% in AMS-treated patients (difference between the groups, 8.05; 95% CI, -5.74 to 22.76). The mean reduction in RSI was 27.2% for the PS group and 39.8% in the AMS group (difference, 12.10; 95% CI, 1.53 to 22.68). Conclusions and Relevance: Our data suggest that the effect of PPI on the RSI based on proportion reaching a 6-point reduction in RSI is not significantly better than that of alkaline water, a plant-based, Mediterranean-style diet, and standard reflux precautions, although the difference in the 2 treatments could be clinically meaningful in favor of the dietary approach. The percent reduction in RSI was significantly greater with the dietary approach. Because the relationship between percent change and response to treatment has not been studied, the clinical significance of this difference requires further study. Nevertheless, this study suggests that a plant-based diet and alkaline water should be considered in the treatment of LPR. This approach may effectively improve symptoms and could avoid the costs and adverse effects of pharmacological intervention as well as afford the additional health benefits associated with a healthy, plant-based diet.
[Mh] Termos MeSH primário: Antiácidos/uso terapêutico
Dieta Mediterrânea
Refluxo Laringofaríngeo/dietoterapia
Refluxo Laringofaríngeo/tratamento farmacológico
Inibidores da Bomba de Prótons/uso terapêutico
Água
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Refluxo Laringofaríngeo/diagnóstico
Masculino
Meia-Idade
Estudos Retrospectivos
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antacids); 0 (Proton Pump Inhibitors); 059QF0KO0R (Water)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170908
[St] Status:MEDLINE
[do] DOI:10.1001/jamaoto.2017.1454


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[PMID]:28875870
[Au] Autor:Jacobs S; Boushey CJ; Franke AA; Shvetsov YB; Monroe KR; Haiman CA; Kolonel LN; Le Marchand L; Maskarinec G
[Ad] Endereço:1Epidemiology Program,University of Hawaii Cancer Center,Honolulu,HI 96813,USA.
[Ti] Título:A priori-defined diet quality indices, biomarkers and risk for type 2 diabetes in five ethnic groups: the Multiethnic Cohort.
[So] Source:Br J Nutr;118(4):312-320, 2017 Aug.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Dietary indices have been related to risk for type 2 diabetes (T2D) predominantly in white populations. The present study evaluated this association in the ethnically diverse Multiethnic Cohort and examined four diet quality indices in relation to T2D risk, homoeostatic model assessment-estimated insulin resistance (HOMA-IR) and biomarkers of dyslipidaemia, inflammation and adipokines. The T2D analysis included 166 550 white, African American, Native Hawaiian, Japanese American and Latino participants (9200 incident T2D cases). Dietary intake was assessed at baseline using a quantitative FFQ and T2D status was based on three self-reports and confirmed by administrative data. Biomarkers were assessed about 10 years later in a biomarker subcohort (n 10 060). Sex- and ethnicity-specific hazard ratios were calculated for the Healthy Eating Index-2010 (HEI-2010), the alternative HEI-2010 (AHEI-2010), the alternate Mediterranean diet score (aMED) and the Dietary Approaches to Stop Hypertension (DASH). Multivariable-adjusted means of biomarkers were compared across dietary index tertiles in the biomarker subcohort. The AHEI-2010, aMED (in men only) and DASH scores were related to a 10-20 % lower T2D risk, with the strongest associations in whites and the direction of the relationships mostly consistent across ethnic groups. Higher scores on the four indices were related to lower HOMA-IR, TAG and C-reactive protein concentrations, not related to leptin, and the DASH score was directly associated with adiponectin. The AHEI-2010 and DASH were directly related to HDL-cholesterol in women. Potential underlying biological mechanisms linking diet quality and T2D risk are an improved lipid profile and reduced systemic inflammation and, with regards to DASH alone, an improved adiponectin profile.
[Mh] Termos MeSH primário: Afroamericanos
Grupo com Ancestrais do Continente Asiático
Diabetes Mellitus Tipo 2/prevenção & controle
Dieta
Grupo com Ancestrais do Continente Europeu
Hispano-Americanos
Grupo com Ancestrais Oceânicos
[Mh] Termos MeSH secundário: Adiponectina/sangue
Idoso
Proteína C-Reativa/metabolismo
HDL-Colesterol/sangue
Estudos de Coortes
Diabetes Mellitus Tipo 2/sangue
Diabetes Mellitus Tipo 2/etnologia
Dieta/normas
Dieta Mediterrânea
Dislipidemias/sangue
Dislipidemias/prevenção & controle
Grupos Étnicos
Feminino
Seres Humanos
Hipertensão
Inflamação/sangue
Inflamação/prevenção & controle
Resistência à Insulina
Japão
Masculino
Meia-Idade
Triglicerídeos/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adiponectin); 0 (Cholesterol, HDL); 0 (Triglycerides); 9007-41-4 (C-Reactive Protein)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517002033


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[PMID]:28829991
[Au] Autor:May-Wilson S; Sud A; Law PJ; Palin K; Tuupanen S; Gylfe A; Hänninen UA; Cajuso T; Tanskanen T; Kondelin J; Kaasinen E; Sarin AP; Eriksson JG; Rissanen H; Knekt P; Pukkala E; Jousilahti P; Salomaa V; Ripatti S; Palotie A; Renkonen-Sinisalo L; Lepistö A; Böhm J; Mecklin JP; Al-Tassan NA; Palles C; Farrington SM; Timofeeva MN; Meyer BF; Wakil SM; Campbell H; Smith CG; Idziaszczyk S; Maughan TS; Fisher D; Kerr R; Kerr D; Passarelli MN; Figueiredo JC; Buchanan DD; Win AK; Hopper JL; Jenkins MA; Lindor NM; Newcomb PA; Gallinger S; Conti D; Schumacher F; Casey G; Aaltonen LA
[Ad] Endereço:Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
[Ti] Título:Pro-inflammatory fatty acid profile and colorectal cancer risk: A Mendelian randomisation analysis.
[So] Source:Eur J Cancer;84:228-238, 2017 Oct.
[Is] ISSN:1879-0852
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: While dietary fat has been established as a risk factor for colorectal cancer (CRC), associations between fatty acids (FAs) and CRC have been inconsistent. Using Mendelian randomisation (MR), we sought to evaluate associations between polyunsaturated (PUFA), monounsaturated (MUFA) and saturated FAs (SFAs) and CRC risk. METHODS: We analysed genotype data on 9254 CRC cases and 18,386 controls of European ancestry. Externally weighted polygenic risk scores were generated and used to evaluate associations with CRC per one standard deviation increase in genetically defined plasma FA levels. RESULTS: Risk reduction was observed for oleic and palmitoleic MUFAs (OR = 0.77, 95% CI: 0.65-0.92, P = 3.9 × 10 ; OR = 0.36, 95% CI: 0.15-0.84, P = 0.018). PUFAs linoleic and arachidonic acid had negative and positive associations with CRC respectively (OR = 0.95, 95% CI: 0.93-0.98, P = 3.7 × 10 ; OR = 1.05, 95% CI: 1.02-1.07, P = 1.7 × 10 ). The SFA stearic acid was associated with increased CRC risk (OR = 1.17, 95% CI: 1.01-1.35, P = 0.041). CONCLUSION: Results from our analysis are broadly consistent with a pro-inflammatory FA profile having a detrimental effect in terms of CRC risk.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/genética
Neoplasias Colorretais/genética
Dieta/efeitos adversos
Ácidos Graxos/efeitos adversos
Mediadores da Inflamação/efeitos adversos
Polimorfismo de Nucleotídeo Único
[Mh] Termos MeSH secundário: Estudos de Casos e Controles
Neoplasias Colorretais/sangue
Neoplasias Colorretais/etnologia
Neoplasias Colorretais/prevenção & controle
Dieta Mediterrânea
Grupo com Ancestrais do Continente Europeu/genética
Ácidos Graxos/sangue
Interação Gene-Ambiente
Predisposição Genética para Doença
Estudo de Associação Genômica Ampla
Dieta Saudável
Seres Humanos
Mediadores da Inflamação/sangue
Análise da Randomização Mendeliana
Razão de Chances
Fenótipo
Fatores de Proteção
Medição de Risco
Fatores de Risco
Comportamento de Redução do Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Fatty Acids); 0 (Inflammation Mediators)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE


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[PMID]:28814398
[Au] Autor:Toledo E; Wang DD; Ruiz-Canela M; Clish CB; Razquin C; Zheng Y; Guasch-Ferré M; Hruby A; Corella D; Gómez-Gracia E; Fiol M; Estruch R; Ros E; Lapetra J; Fito M; Aros F; Serra-Majem L; Liang L; Salas-Salvadó J; Hu FB; Martínez-González MA
[Ad] Endereço:Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain.
[Ti] Título:Plasma lipidomic profiles and cardiovascular events in a randomized intervention trial with the Mediterranean diet.
[So] Source:Am J Clin Nutr;106(4):973-983, 2017 Oct.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lipid metabolites may partially explain the inverse association between the Mediterranean diet (MedDiet) and cardiovascular disease (CVD). We evaluated the associations between ) lipid species and the risk of CVD (myocardial infarction, stroke, or cardiovascular death); ) a MedDiet intervention [supplemented with extra virgin olive oil (EVOO) or nuts] and 1-y changes in these molecules; and ) 1-y changes in lipid species and subsequent CVD. With the use of a case-cohort design, we profiled 202 lipid species at baseline and after 1 y of intervention in the PREDIMED (PREvención con DIeta MEDiterránea) trial in 983 participants [230 cases and a random subcohort of 790 participants (37 overlapping cases)]. Baseline concentrations of cholesterol esters (CEs) were inversely associated with CVD. A shorter chain length and higher saturation of some lipids were directly associated with CVD. After adjusting for multiple testing, direct associations remained significant for 20 lipids, and inverse associations remained significant for 6 lipids. When lipid species were weighted by the number of carbon atoms and double bonds, the strongest inverse association was found for CEs [HR: 0.39 (95% CI: 0.22, 0.68)] between extreme quintiles ( -trend = 0.002). Participants in the MedDiet + EVOO and MedDiet + nut groups experienced significant ( < 0.05) 1-y changes in 20 and 17 lipids, respectively, compared with the control group. Of these changes, only those in CE(20:3) in the MedDiet + nuts group remained significant after correcting for multiple testing. None of the 1-y changes was significantly associated with CVD risk after correcting for multiple comparisons. Although the MedDiet interventions induced some significant 1-y changes in the lipidome, they were not significantly associated with subsequent CVD risk. Lipid metabolites with a longer acyl chain and higher number of double bonds at baseline were significantly and inversely associated with the risk of CVD.
[Mh] Termos MeSH primário: Doenças Cardiovasculares/sangue
Dieta Mediterrânea
Gorduras na Dieta/sangue
Lipídeos/sangue
Nozes
Azeite de Oliva
[Mh] Termos MeSH secundário: Idoso
Doenças Cardiovasculares/prevenção & controle
Ésteres do Colesterol/sangue
Gorduras na Dieta/análise
Suplementos Nutricionais
Feminino
Seres Humanos
Metabolismo dos Lipídeos
Masculino
Meia-Idade
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Cholesterol Esters); 0 (Dietary Fats); 0 (Lipids); 0 (Olive Oil)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.151159


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[PMID]:28814394
[Au] Autor:Tsaban G; Wolak A; Avni-Hassid H; Gepner Y; Shelef I; Henkin Y; Schwarzfuchs D; Cohen N; Bril N; Rein M; Serfaty D; Kenigsbuch S; Tene L; Zelicha H; Yaskolka-Meir A; Komy O; Bilitzky A; Chassidim Y; Ceglarek U; Stumvoll M; Blüher M; Thiery J; Dicker D; Rudich A; Stampfer MJ; Shai I
[Ad] Endereço:Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
[Ti] Título:Dynamics of intrapericardial and extrapericardial fat tissues during long-term, dietary-induced, moderate weight loss.
[So] Source:Am J Clin Nutr;106(4):984-995, 2017 Oct.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In view of evidence linking pericardial fat accumulation with increased cardiovascular disease risk, strategies to reduce its burden are needed. Data comparing the effects of specific long-term dietary interventions on pericardial fat tissue mobilization are sparse. We sought to evaluate intrapericardial-fat (IPF) and extrapericardial-fat (EPF) changes during weight-loss interventions by different dietary regimens. During 18 mo of a randomized controlled trial, we compared a Mediterranean/low-carbohydrate (MED/LC) diet plus 28 g walnuts/d with a calorically equal low-fat (LF) diet among randomly assigned participants with moderate abdominal obesity. We performed whole-body MRI and volumetrically quantified IPF and EPF among 80 participants to follow the 18-mo changes. The participants [mean age: 48.6 y; mean body mass index (BMI; in kg/m ); 31.7; 90% men] had baseline IPF and EPF (mean ± SD) volumes of 172.4 ± 53.3 mL and 194.9 ± 71.5 mL, respectively. The 18-mo moderate weight loss of 3.7 kg was similar in both groups, but the reduction in waist circumference was higher in the MED/LC group (-6.9 ± 6.6 cm) than in the LF diet group (-2.3 ± 6.5 cm; = 0.01). After 18 mo, the IPF volume had reduced twice as much in the MED/LC group compared with the LF group [-37 ± 26.2 mL (-22% ± 15%) compared with -15.5 ± 26.2 mL (-8% ± 15%), respectively; < 0.05, after adjustment for changes in weight or visceral adipose tissue]. The EPF volume had reduced similarly in both groups [-41.6 ± 30.2 mL (-23% ± 16%) in the MED/LC group compared with -37.9 ± 28.3 mL (-19% ± 14%) in the LF group; > 0.1]. After controlling for weight loss, IPF and EPF volume reduction paralleled changes in lipid profile but not with improved glycemic profile variables: the IPF relative reduction was associated with a decrease in triglycerides (TGs) (ß = 0.090; 95% CI: 0.026, 0.154; = 0.007) and the ratio of TGs to high-density lipoprotein (HDL) cholesterol (ß = 2.689; 95% CI: 0.373, 5.003; = 0.024), and the EPF relative reduction was associated with an increase in HDL cholesterol (ß = -0.452; 95% CI: -0.880, -0.023; = 0.039) and a decrease in total cholesterol and HDL cholesterol (ß = 3.766; 95% CI: 1.092, 6.440; = 0.007). Moderate but persistent dietary-induced weight loss substantially decreased both IPF and EPF volumes. Reduction of pericardial adipose tissues is independently associated with an improved lipid profile. The Mediterranean diet, rich in unsaturated fats and restricted carbohydrates, is superior to an LF diet in terms of the IPF burden reduction. This trial was registered at clinicaltrials.gov as NCT01530724.
[Mh] Termos MeSH primário: Tecido Adiposo/metabolismo
Dieta Redutora/métodos
Carboidratos da Dieta/farmacologia
Gorduras na Dieta/farmacologia
Obesidade/dietoterapia
Pericárdio/metabolismo
Perda de Peso/fisiologia
[Mh] Termos MeSH secundário: Adiposidade
Adulto
Índice de Massa Corporal
Dieta com Restrição de Carboidratos
Dieta com Restrição de Gorduras
Dieta Mediterrânea
Carboidratos da Dieta/administração & dosagem
Gorduras na Dieta/administração & dosagem
Gorduras na Dieta/metabolismo
Feminino
Seres Humanos
Gordura Intra-Abdominal
Lipídeos/sangue
Masculino
Meia-Idade
Nozes
Obesidade/sangue
Obesidade Abdominal/sangue
Obesidade Abdominal/dietoterapia
Circunferência da Cintura
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Carbohydrates); 0 (Dietary Fats); 0 (Lipids)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.117.157115


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[PMID]:28813467
[Au] Autor:Farchi S; De Sario M; Lapucci E; Davoli M; Michelozzi P
[Ad] Endereço:Department of Epidemiology of Regional Health Service, ASL Roma 1, Lazio Region, Rome, Italy.
[Ti] Título:Meat consumption reduction in Italian regions: Health co-benefits and decreases in GHG emissions.
[So] Source:PLoS One;12(8):e0182960, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Animal agriculture has exponentially grown in recent decades in response to the rise in global demand for meat, even in countries like Italy that traditionally eat a Mediterranean, plant-based diet. Globalization related dietary changes are contributing to the epidemic of non-communicable diseases and to the global climate crisis, and are associated with huge carbon and water footprints. The objective of the study is to assess inequalities in health impacts and in attributable greenhouse gases-GHG emissions in Italy by hypothesizing different scenarios of reduction in red and processed meat consumption towards healthier consumption patterns more compliant with the recommendations of the Mediterranean food pyramid. METHODS: We used demographic and food consumption patterns from national surveys and risk relationships between meat intake and cardiovascular and colorectal cancer mortality from IARC and other meta-analyses. From the baseline data (year 2005-2006, average 406 gr/week beef and 245 gr/week processed meat), we considered hypothetical meat reduction scenarios according to international dietary guidelines such as the Mediterranean pyramid targets. For each geographical area (Northwest, Northeast, Centre, and South) and gender, we calculated the number of avoidable deaths from colorectal cancer, and cardiovascular disease among the adult population. Moreover, years of life gained by the adult population from 2012 to 2030 and changes in life expectancy of the 2012 birth cohort were quantified using gender-specific life tables. GHG emission reductions under Mediterranean scenario were estimated only for beef by applying the Global Warming Potential (GWP) coefficient to total consumption and to a low carbon food substitution in adult diet. RESULTS: The deaths avoidable (as percentage change compared to baseline) according to the three reduction scenarios for beef consumption were between 2.3% and 4.5% for colorectal cancer, and between 2.1% and 4.0% for cardiovascular disease; higher benefits would be observed in Northwestern areas and among males. In parallel, 5% and 6.4% of colorectal cancer and CVD deaths would be avoided if the Italian population ate the advised quantity of processed meat. Life table analysis suggests that the scenario that is fully compliant with the Mediterranean diet model would save 5 million years of life lost prematurely among men and women over the next 18 years and would increase average life expectancy of future generations by over 7 months. Considering the environmental impact, emissions associated with the actual total intake of beef range from 12,900 to 21,800 Gg CO2 eq; emissions saved according to the Mediterranean scenario are in the range 8000-14000 Gg CO2 eq per year. The per capita reduction is 263 KgCO2eq/year/person with higher reductions in Northwestern and Central areas. CONCLUSIONS: In Italy, scenarios for reducing beef consumption are consistent with significant health and environmental co-benefits on current and future generations. Results support introducing policies to promote healthier behavior towards red and processed meat in the adult population within an overall balanced and healthy dietary pattern. Interventions should address gender, vulnerable population groups, and geographical differences in order to be more effective.
[Mh] Termos MeSH primário: Dieta/tendências
Efeito Estufa
Carne
[Mh] Termos MeSH secundário: Adolescente
Adulto
Dieta/estatística & dados numéricos
Dieta Mediterrânea
Comportamento Alimentar/fisiologia
Feminino
Promoção da Saúde/estatística & dados numéricos
Nível de Saúde
Seres Humanos
Itália
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170817
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182960



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