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[PMID]:28462759
[Au] Autor:Madeira MS; Lopes PA; Costa P; Coelho D; Alfaia CM; Prates JAM
[Ad] Endereço:CIISA,Faculdade de Medicina Veterinária,Universidade de Lisboa,1300-477 Lisboa,Portugal.
[Ti] Título:Reduced protein diets increase intramuscular fat of psoas major, a red muscle, in lean and fatty pig genotypes.
[So] Source:Animal;11(11):2094-2102, 2017 Nov.
[Is] ISSN:1751-732X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The present study aims to assess the effects of pig's genotype (lean v. fatty) and dietary protein level (control v. reduced) on intramuscular fat (IMF) content, fatty acid composition and fibre profile of psoas major, a representative red muscle in pig's carcass scarcely studied relative to white longissimus lumborum. The experiment was conducted on 40 intact male pigs (20 Alentejana purebred and 20 Large White×Landrace×Pietrain crossbred) from 60 to 93 kg of live weight. Pigs were divided and allocated to four dietary groups: control protein diet equilibrated for lysine (17.5% of CP and 0.7% of lysine) and reduced protein diet (RPD) not equilibrated for lysine (13.1% of crude protein and 0.4% of lysine) within a 2×2 factorial arrangement (two genotypes and two diets). Alentejana purebred had higher IMF content (15.7%) and monounsaturated fatty acids (MUFA) (8.9%), whereas crossbred pigs had higher PM weight (46.3%) and polyunsaturated fatty acids (PUFA) (20.1%). The genotype also affected colour with higher lightness (15.1%) and yellowness (33.8%) and lower redness (9.9%) scores in crossbred pigs. In line with this, fatty pigs displayed more oxidative fibres (29.5%), whilst lean pigs had more glycolytic (54.4%). Relative to fatty acids, RPD increased MUFA (5.2%) and SFA (3.2%) but decreased PUFA (14.8%). Ultimately, RPD increased IMF content (15.7%) in the red muscle under study, with no impact on glycolytic to oxidative fibre type transformation.
[Mh] Termos MeSH primário: Tecido Adiposo/metabolismo
Criação de Animais Domésticos
Dieta com Restrição de Proteínas/veterinária
Músculos Psoas/metabolismo
Sus scrofa/metabolismo
[Mh] Termos MeSH secundário: Animais
Genótipo
Masculino
Distribuição Aleatória
Sus scrofa/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180126
[Lr] Data última revisão:
180126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1017/S1751731117000921


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[PMID]:29237116
[Au] Autor:Inglis J
[Ti] Título:HOPE FOR PKU. FUTURE.
[So] Source:Aust Nurs Midwifery J;24(1):35, 2016 07.
[Is] ISSN:2202-7114
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:I have been living with Phenylketonuria (PKU) for 45 years. My journey has been challenging for many reasons but mostly related to how the disease is viewed and the lack of awareness.
[Mh] Termos MeSH primário: Fenilcetonúrias/dietoterapia
Autocuidado
[Mh] Termos MeSH secundário: Dieta com Restrição de Proteínas
Feminino
Seres Humanos
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE; PERSONAL NARRATIVES
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE


  3 / 2334 MEDLINE  
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[PMID]:29227606
[Au] Autor:Kopylchuk GP; Voloshchuk OM
[Ti] Título:Peculiarities of the free radical processes in rat liver mitochondria under toxic hepatitis on the background of alimentary protein deficiency.
[So] Source:Ukr Biochem J;88(2):66-72, 2016 Mar-Apr.
[Is] ISSN:2409-4943
[Cp] País de publicação:Ukraine
[La] Idioma:eng
[Ab] Resumo:The rate of superoxide anion radical, hydroxyl radical and hydrogen peroxide generation, the level of oxidative modification of mitochondrial proteins in the liver of rats with toxic hepatitis was investigated on the background of alimentary protein deficiency. We did not find significant increases of the intensity of free radical processes in liver mitochondria of rats maintained on the protein-deficient ration. The most significant intensification of free radical processes in liver mitochondria is observed under the conditions of toxic hepatitis, induced on the background of alimentary protein deprivation. Under these conditions the aggravation of all studied forms of reactive oxygen species generation was observed in liver mitochondria. The generation rates were increased as follows: O2 ­ by 1.7 times, Н2О2 ­ by 1.5 times, •ОН ­ practically double on the background of accumulation of oxidized mitochondria-derived proteins. The established changes in thiol groups' redox status of respiratory chain proteins insoluble in 0.05 M sodium-phosphate buffer (pH 11.5), and changes of their carbonyl derivatives content may be considered as one of the regulatory factors of mitochondrial energy-generating function.
[Mh] Termos MeSH primário: Doença Hepática Induzida por Substâncias e Drogas/metabolismo
Peróxido de Hidrogênio/metabolismo
Radical Hidroxila/metabolismo
Mitocôndrias Hepáticas/metabolismo
Deficiência de Proteína/metabolismo
Superóxidos/metabolismo
[Mh] Termos MeSH secundário: Acetaminofen/toxicidade
Animais
Animais não Endogâmicos
Doença Hepática Induzida por Substâncias e Drogas/complicações
Doença Hepática Induzida por Substâncias e Drogas/patologia
Dieta com Restrição de Proteínas/efeitos adversos
Peróxido de Hidrogênio/agonistas
Radical Hidroxila/agonistas
Fígado/efeitos dos fármacos
Fígado/metabolismo
Fígado/patologia
Mitocôndrias Hepáticas/efeitos dos fármacos
Oxirredução
Estresse Oxidativo
Carbonilação Proteica
Deficiência de Proteína/complicações
Deficiência de Proteína/etiologia
Deficiência de Proteína/patologia
Ratos
Superóxidos/agonistas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
11062-77-4 (Superoxides); 3352-57-6 (Hydroxyl Radical); 362O9ITL9D (Acetaminophen); BBX060AN9V (Hydrogen Peroxide)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE
[do] DOI:10.15407/ubj88.02.066


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[PMID]:28747486
[Au] Autor:Chalvon-Demersay T; Even PC; Chaumontet C; Piedcoq J; Viollet B; Gaudichon C; Tomé D; Foretz M; Azzout-Marniche D
[Ad] Endereço:UMR Nutrition Physiology and Ingestive Behavior, AgroParisTech, INRA, Paris-Saclay University, Paris, France.
[Ti] Título:Modifying the Dietary Carbohydrate-to-Protein Ratio Alters the Postprandial Macronutrient Oxidation Pattern in Liver of AMPK-Deficient Mice.
[So] Source:J Nutr;147(9):1669-1676, 2017 09.
[Is] ISSN:1541-6100
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hepatic AMP-activated kinase (AMPK) activity is sensitive to the dietary carbohydrate-to-protein ratio. However, the role of AMPK in metabolic adaptations to variations in dietary macronutrients remains poorly understood. The objective of this study was to determine the role of hepatic AMPK in the adaptation of energy metabolism in response to modulation of the dietary carbohydrate-to-protein ratio. Male 7-wk-old wild-type (WT) and liver AMPK-deficient (knockout) mice were fed either a normal-protein and normal-carbohydrate diet (NP-NC; 14% protein, 76% carbohydrate on an energy basis), a low-protein and high-carbohydrate diet (LP-HC; 5% protein, 85% carbohydrate), or a high-protein and low-carbohydrate diet (HP-LC; 55% protein, 35% carbohydrate) for 3 wk. During this period, after an overnight fast, metabolic parameters were measured and indirect calorimetry was performed in mice during the first hours after refeeding a 1-g calibrated meal of their own diet in order to investigate lipid and carbohydrate metabolism. Knockout mice fed an LP-HC or HP-LC meal exhibited 24% and 8% lower amplitudes in meal-induced carbohydrate and lipid oxidation changes. By contrast, knockout mice fed an NP-NC meal displayed normal carbohydrate and lipid oxidation profiles. These mice exhibited a transient increase in hepatic triglycerides and a decrease in hepatic glycogen. These changes were associated with a 650% higher secretion of fibroblast growth factor 21 (FGF21) 2 h after refeeding. The consequences of hepatic AMPK deletion depend on the dietary carbohydrate-to-protein ratio. In mice fed the NP-NC diet, deletion of AMPK in the liver led to an adaptation of liver metabolism resulting in increased secretion of FGF21. These changes possibly compensated for the absence of hepatic AMPK, as these mice exhibited normal postprandial changes in carbohydrate and lipid oxidation. By contrast, in mice fed the LP-HC and HP-LC diets, the lack of adjustment in liver metabolism in knockout mice resulted in a metabolic inflexibility, leading to a reduced amplitude of meal-induced changes in carbohydrate and lipid oxidation.
[Mh] Termos MeSH primário: Proteínas Quinases Ativadas por AMP/metabolismo
Metabolismo dos Carboidratos
Carboidratos da Dieta/administração & dosagem
Proteínas na Dieta/administração & dosagem
Metabolismo dos Lipídeos
Fígado/efeitos dos fármacos
Período Pós-Prandial
[Mh] Termos MeSH secundário: Proteínas Quinases Ativadas por AMP/deficiência
Adaptação Fisiológica
Animais
Dieta
Dieta com Restrição de Carboidratos
Dieta com Restrição de Proteínas
Carboidratos da Dieta/metabolismo
Carboidratos da Dieta/farmacologia
Gorduras na Dieta/metabolismo
Proteínas na Dieta/metabolismo
Proteínas na Dieta/farmacologia
Metabolismo Energético/efeitos dos fármacos
Jejum
Fatores de Crescimento de Fibroblastos/metabolismo
Glicogênio/metabolismo
Fígado/metabolismo
Masculino
Refeições
Camundongos Knockout
Oxirredução
Triglicerídeos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Dietary Carbohydrates); 0 (Dietary Fats); 0 (Dietary Proteins); 0 (Triglycerides); 0 (fibroblast growth factor 22, mouse); 62031-54-3 (Fibroblast Growth Factors); 9005-79-2 (Glycogen); EC 2.7.11.31 (AMP-Activated Protein Kinases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171215
[Lr] Data última revisão:
171215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.3945/jn.117.250803


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[PMID]:28745686
[Au] Autor:Milovanova SY; Milovanov YS; Taranova MV; Dobrosmyslov IA
[Ad] Endereço:I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.
[Ti] Título:[Effects of keto/amino acids and a low-protein diet on the nutritional status of patients with Stages 3B-4 chronic kidney disease].
[Ti] Título:Vliianie keto/aminokislot i ogranicheniia belka na status pitaniia bol'nykh khronicheskoi bolezn'iu pochek IIIB-IV stadii..
[So] Source:Ter Arkh;89(6):30-33, 2017.
[Is] ISSN:0040-3660
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:AIM: To evaluate the efficacy of keto/amino acids in maintaining protein balance and preventing mineral metabolic disturbances and the development of uremic hyperparathyroidism in the long-term use of a low-protein diet (LPD) in patients with Stages 3B-4 chronic kidney disease (CKD). SUBJECTS AND METHODS: Ninety patients with CKD caused by chronic latent glomerulonephritis in 65 patients and chronic tubulointerstitial nephritis of various etiologies (gout, drug-induced, and infection) in 25 were examined. The investigators conducted clinical, laboratory, and instrumental examinations, including bioelectrical impedance analysis (body mass index (BMI), the percentages of lean and fat mass), echocardiography and radiography of the abdominal aorta in the lateral projection (the presence of cardiac valvular and aortic calcification), and pulse wave velocity measurements using a Sphygmocor apparatus (vessel stiffness estimation). The stages of CKD were defined according to the 2012 Kidney Disease: Improving Global Outcomes (KDIGO) criteria; glomerular filtration rate was calculated using the CKD EPI equation. According to the diet used, all the patients were divided into 3 groups: 1) 30 patients who took LPD (0.6 g of protein per kg of body weight/day) in combination with the keto/amino acid ketosteril (1 tablet per 5 kg of body weight/day; Diet One); 2) 30 patients who used LPD in combination with the other keto/amino acid ketoaminol at the same dose (Diet Two); 3) 30 patients had LPD without using the keto/amino acids (Diet Three) (a control group). RESULTS: During a follow-up, there were no signs of malnutrition in Groups 1 and 2 patients receiving LPD (0.6 g protein per kg/day) in combination with the keto/amino acids ketosteril and ketaminol, respectively. At the same time, 11 (36.6%) patients in Group 3 (a control group) who did not take the keto/amino acids showed a BMI decrease from 24 (23; 26) kg/m2 to 18.5 (17; 19.2) kg/m2 (p < 0.05), including that of lean body mass from 37.4 (36; 38.8) to 30 (29.1; 34.7)% in the men (p<0.05) and from 29.8 (26.8; 31) to 23.9 (22; 25.7)% in the women (p<0.01). In addition, at the end of the study, there were elevated serum phosphorus levels (p<0.05) and mainly higher parathyroid hormone concentrations in Group 3 patients who received LPD without using the amino/keto acids than in Groups 1 and 2. As compared to Group 3, Groups 1 and 2 displayed no differences in the quantity of cardiac and aortic calcification and in the augmentation index (arterial stiffness). The ketosteril and ketaminol groups versus the control group had also higher s-Klotho levels (p<0.01) that were inversely correlated with glomerular filtration rate (r =-0.467; p<0.01). CONCLUSION: The keto/amino acids ketosteril or ketoaminol are an important component of LPD, which prevents malnutrition and an additional source of calcium that inhibits hyperphosphatemia and slows the development of uremic hyperparathyroidism. Incorporation of keto/amino acids into LPD leads to a less pronounced reduction in s-Klotho protein in relation to the degree of renal failure than does LPD without keto/amino acids.
[Mh] Termos MeSH primário: Aminoácidos Essenciais/farmacologia
Aminoácidos/farmacologia
Dieta com Restrição de Proteínas/métodos
Glucuronidase/sangue
Cetoácidos/farmacologia
Avaliação de Resultados (Cuidados de Saúde)
Insuficiência Renal Crônica
[Mh] Termos MeSH secundário: Adulto
Idoso
Aminoácidos/administração & dosagem
Aminoácidos Essenciais/administração & dosagem
Terapia Combinada
Dieta com Restrição de Proteínas/efeitos adversos
Feminino
Seguimentos
Seres Humanos
Cetoácidos/administração & dosagem
Masculino
Meia-Idade
Insuficiência Renal Crônica/sangue
Insuficiência Renal Crônica/diagnóstico
Insuficiência Renal Crônica/dietoterapia
[Pt] Tipo de publicação:CONTROLLED CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids); 0 (Amino Acids, Essential); 0 (Keto Acids); 68934-50-9 (ketosteril); EC 3.2.1.31 (Glucuronidase); EC 3.2.1.31 (klotho protein)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171129
[Lr] Data última revisão:
171129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.17116/terarkh201789630-33


  6 / 2334 MEDLINE  
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[PMID]:29091561
[Au] Autor:Kalantar-Zadeh K; Fouque D
[Ad] Endereço:From the Harold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California, Irvine, School of Medicine, Orange, the Long Beach Veterans Affairs Healthcare System, Long Beach, the Department of Epidemiology, University of California, Los Angeles (UCLA), and the Los Angeles Biomedical Research Institute at Harbor-UCLA, Torrance - all in California (K.K.-Z.); and the Department of Nephrology, Université Claude Bernard Lyon, Centre Hospitalier Lyon Sud, Cardiometabolism and Nutrition (CarMeN), Lyon, France (D.F.).
[Ti] Título:Nutritional Management of Chronic Kidney Disease.
[So] Source:N Engl J Med;377(18):1765-1776, 2017 Nov 02.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Dieta com Restrição de Proteínas
Dieta Hipossódica
Insuficiência Renal Crônica/dietoterapia
[Mh] Termos MeSH secundário: Acidose/etiologia
Acidose/prevenção & controle
Adulto
Seres Humanos
Necessidades Nutricionais
Insuficiência Renal Crônica/complicações
Insuficiência Renal Crônica/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171102
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMra1700312


  7 / 2334 MEDLINE  
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[PMID]:28938440
[Au] Autor:Larson KR; Russo KA; Fang Y; Mohajerani N; Goodson ML; Ryan KK
[Ad] Endereço:Department of Neurobiology, Physiology, and Behavior, College of Biological Sciences, University of California, Davis, Davis, California 95616.
[Ti] Título:Sex Differences in the Hormonal and Metabolic Response to Dietary Protein Dilution.
[So] Source:Endocrinology;158(10):3477-3487, 2017 Oct 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Consumption of a low-protein, high-carbohydrate diet induces a striking increase in circulating fibroblast growth factor-21 (FGF21), which is associated with improved cardiometabolic health and increased longevity. Increased lifespan during this dietary protein "dilution" has been explained by resource-mediated trade-offs between reproduction and survival, such that fecundity is optimized at a greater relative intake of proteins/carbohydrates. The magnitude of this trade-off is thought to be sex-dependent. In this study, we tested the hypothesis that metabolic responses to dietary protein dilution are likewise dependent on sex. We maintained age-matched adult male and female C57BL/6J mice on isocaloric diets containing 22% fat and differing in the ratio of protein/carbohydrate. The normal protein (NP) control diet contained 18% protein and 60% carbohydrate by kcal. The protein diluted (PD) diet contained 4% protein and 74% carbohydrate. Consistent with previous reports, PD males gained less weight and less fat than did normal protein controls and exhibited both improved glucose tolerance and decreased plasma lipids. In contrast, these metabolic benefits were absent among age-matched females maintained on the same diets. Likewise, whereas circulating FGF21 was increased up to 66-fold among PD male mice, this was substantially blunted among female counterparts. Sex differences in energy balance, glucose control, and plasma FGF21 were reversed upon ovariectomy. Collectively, our findings support that female mice are relatively less sensitive to the metabolic improvements observed following dietary protein dilution. This is accompanied by blunted circulating levels of FGF21 and requires an intact female reproductive system.
[Mh] Termos MeSH primário: Glicemia/metabolismo
Dieta com Restrição de Proteínas
Carboidratos da Dieta
Proteínas na Dieta
Fatores de Crescimento de Fibroblastos/metabolismo
Metabolismo dos Lipídeos
Ganho de Peso
[Mh] Termos MeSH secundário: Animais
Composição Corporal
Ingestão de Energia
Metabolismo Energético
Feminino
Teste de Tolerância a Glucose
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Ovariectomia
Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/genética
RNA Mensageiro/metabolismo
Receptor Tipo 1 de Fator de Crescimento de Fibroblastos/genética
Fatores Sexuais
Transcriptoma
Proteína Desacopladora 1/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Dietary Carbohydrates); 0 (Dietary Proteins); 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha); 0 (Ppargc1a protein, mouse); 0 (RNA, Messenger); 0 (Ucp1 protein, mouse); 0 (Uncoupling Protein 1); 0 (fibroblast growth factor 21); 62031-54-3 (Fibroblast Growth Factors); EC 2.7.10.1 (Fgfr1 protein, mouse); EC 2.7.10.1 (Receptor, Fibroblast Growth Factor, Type 1)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170923
[St] Status:MEDLINE
[do] DOI:10.1210/en.2017-00331


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[PMID]:28934453
[Au] Autor:Jones EN; Amoah S; Cao W; Sambhara S; Gangappa S
[Ad] Endereço:Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
[Ti] Título:An Adjuvanted A(H5N1) Subvirion Vaccine Elicits Virus-Specific Antibody Response and Improves Protection Against Lethal Influenza Viral Challenge in Mouse Model of Protein Energy Malnutrition.
[So] Source:J Infect Dis;216(suppl_4):S560-S565, 2017 Sep 15.
[Is] ISSN:1537-6613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background: Protein energy malnutrition (PEM) increases susceptibility to infectious diseases, including influenza infection, but no studies have addressed the potential influences of PEM on the immunogenicity and protective efficacy of avian influenza A(H5N1) vaccine. Methods: We investigated the role of PEM on vaccine-mediated protection after a lethal challenge with recombinant A(H5N1) virus using isocaloric diets providing either adequate protein (AP; 18% protein) or very low protein (VLP; 2% protein) in an established murine model of influenza vaccination. Results: We demonstrated that mice maintained on a VLP diet succumb to lethal challenge at greater rates than mice maintained on an AP diet, despite comparable immunization regimens. Importantly, there was no virus-induced mortality in both VLP and AP groups of mice when either group was immunized with adjuvanted low-dose A(H5N1) subvirion vaccine. Conclusions: Our results suggest that adjuvanted vaccination in populations where PEM is endemic may be one strategy to boost vaccination-promoted immunity and improve outcomes associated with highly pathogenic A(H5N1).
[Mh] Termos MeSH primário: Adjuvantes Imunológicos/administração & dosagem
Formação de Anticorpos
Vacinas contra Influenza/administração & dosagem
Infecções por Orthomyxoviridae/prevenção & controle
Desnutrição Proteico-Calórica/imunologia
[Mh] Termos MeSH secundário: Animais
Dieta com Restrição de Proteínas/efeitos adversos
Proteínas na Dieta/administração & dosagem
Proteínas na Dieta/sangue
Modelos Animais de Doenças
Feminino
Testes de Inibição da Hemaglutinação
Vírus da Influenza A Subtipo H5N1/imunologia
Camundongos
Camundongos Endogâmicos C57BL
Desnutrição Proteico-Calórica/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adjuvants, Immunologic); 0 (Dietary Proteins); 0 (Influenza Vaccines)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jiw585


  9 / 2334 MEDLINE  
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[PMID]:28715436
[Au] Autor:Sevrin T; Alexandre-Gouabau MC; Darmaun D; Palvadeau A; André A; Nguyen P; Ouguerram K; Boquien CY
[Ad] Endereço:UMR PhAN, INRA, CRNH Ouest, Université de Nantes, Nantes, France.
[Ti] Título:Use of water turnover method to measure mother's milk flow in a rat model: Application to dams receiving a low protein diet during gestation and lactation.
[So] Source:PLoS One;12(7):e0180550, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Assessment of milk production is of utmost relevance for pediatricians and scientists interested in early life nutrition. The weight-suckle-weight (WSW) method, which consists of weighing babies before and after they suckle their mother, uses the difference in body weight as an estimate of milk intake. However, this is prone to many sources of error. In the current study, we used for the first time the water turnover method and compartmental analysis with deuterated water (D2O) as a non-toxic tracer to quantify in vivo milk production in a rat model. We assessed the effect of a nutritional intervention presumed to affect milk production, a maternal dietary protein restriction during gestation and lactation, which results in the birth of pups with intrauterine growth restriction. The specific aim of this study was to determine milk production with the body water turnover method in rat dams receiving during gestation and lactation, either a control diet (NP) or an iso-caloric low-protein diet (LP). In NP dams, mass of dam's total body water, output flow constant from dam to litter (K21) and median milk flow, calculated between days 11 to 14 after pup birth, were 282.1 g, 0.0122 h-1 and 3.30 g/h for NP dams, respectively. Maternal dietary protein restriction (-59%) during perinatal period led to a 34% reduction in milk flow (NP versus LP). With the WSW method, milk flow varied from 1.96 g/h to 2.37 g/h between days 11 to 14 for NP dams. The main advantage of the D20 method compared to the WSW method stems from its higher precision, as attested by the narrowest range of measured values of milk flow ([2.90; 3.75] and [0.98; 6.85] g/h, respectively) for NP group. This method could be suitable for testing the effectiveness of candidate galactologue molecules presumed to enhance milk production in the lactating rat model.
[Mh] Termos MeSH primário: Água Corporal/metabolismo
Dieta com Restrição de Proteínas
Lactação
Leite/metabolismo
Mães
[Mh] Termos MeSH secundário: Animais
Água Corporal/química
Óxido de Deutério/química
Feminino
Gravidez
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
J65BV539M3 (Deuterium Oxide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170718
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180550


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[PMID]:28701315
[Au] Autor:Yoshida T; Kakizawa S; Totsuka Y; Sugimoto M; Miura S; Kumagai H
[Ad] Endereço:Department of Clinical Nutrition, School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan; and t-yoshida@u-shizuoka-ken.ac.jp.
[Ti] Título:Effect of endurance training and branched-chain amino acids on the signaling for muscle protein synthesis in CKD model rats fed a low-protein diet.
[So] Source:Am J Physiol Renal Physiol;313(3):F805-F814, 2017 Sep 01.
[Is] ISSN:1522-1466
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A low-protein diet (LPD) protects against the progression of renal injury in patients with chronic kidney disease (CKD). However, LPD may accelerate muscle wasting in these patients. Both exercise and branched-chain amino acids (BCAA) are known to increase muscle protein synthesis by activating the mammalian target of rapamycin (mTOR) pathway. The aim of this study was to investigate whether endurance exercise and BCAA play a role for increasing muscle protein synthesis in LPD-fed CKD (5/6 nephrectomized) rats. Both CKD and sham rats were pair-fed on LPD or LPD fortified with a BCAA diet (BD), and approximately one-half of the animals in each group was subjected to treadmill exercise (15 m/min, 1 h/day, 5 days/wk). After 7 wk, renal function was measured, and soleus muscles were collected to evaluate muscle protein synthesis. Renal function did not differ between LPD- and BD-fed CKD rats, and the treadmill exercise did not accelerate renal damage in either group. The treadmill exercise slightly increased the phosphorylation of p70s6 kinase, a marker of mTOR activity, in the soleus muscle of LPD-fed CKD rats compared with the sham group. Furthermore, BCAA supplementation of the LPD-fed, exercise-trained CKD rats restored the phosphorylation of p70s6 kinase to the same level observed in the sham group; however, the corresponding induced increase in muscle protein synthesis and muscle mass was marginal. These results indicate that the combination of treadmill exercise and BCAA stimulates cell signaling to promote muscle protein synthesis; however, the implications of this effect for muscle growth remain to be clarified.
[Mh] Termos MeSH primário: Aminoácidos de Cadeia Ramificada/administração & dosagem
Dieta com Restrição de Proteínas
Terapia por Exercício/métodos
Proteínas Musculares/biossíntese
Músculo Esquelético/metabolismo
Atrofia Muscular/prevenção & controle
Resistência Física
Insuficiência Renal Crônica/dietoterapia
[Mh] Termos MeSH secundário: Ração Animal
Animais
Dieta com Restrição de Proteínas/efeitos adversos
Modelos Animais de Doenças
Interleucina-6/biossíntese
Interleucina-6/genética
Rim/fisiopatologia
Masculino
Músculo Esquelético/fisiopatologia
Atrofia Muscular/etiologia
Atrofia Muscular/metabolismo
Atrofia Muscular/fisiopatologia
Fosforilação
Proteólise
Ratos Wistar
Insuficiência Renal Crônica/metabolismo
Insuficiência Renal Crônica/fisiopatologia
Proteínas Quinases S6 Ribossômicas 70-kDa/biossíntese
Transdução de Sinais
Serina-Treonina Quinases TOR/biossíntese
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids, Branched-Chain); 0 (Interleukin-6); 0 (Muscle Proteins); EC 2.7.1.1 (TOR Serine-Threonine Kinases); EC 2.7.1.1 (mTOR protein, rat); EC 2.7.11.1 (Ribosomal Protein S6 Kinases, 70-kDa)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.1152/ajprenal.00592.2015



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