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[PMID]:29188952
[Au] Autor:Arkkila P; Nordin A
[Ti] Título:Treatment of ascites and its complications.
[So] Source:Duodecim;132(18):1719-25, 2016.
[Is] ISSN:0012-7183
[Cp] País de publicação:Finland
[La] Idioma:eng
[Ab] Resumo:The underlying cause of ascites should always be treated if possible. Adhering to a low-salt diet is most important in the treatment of ascites. Diuretics are used in the treatment of clinically established and abundant ascites. The first-line drug in diuretic therapy is spironolactone, when necessary in combination with furosemide. The most important complications of ascites are hepatorenal syndrome and spontaneous bacterial peritonitis. The development of ascites lowers the quality of life, and is associated with significant mortality. Although new groundbreaking therapies are not available, prognosis of the patients is expected to be improved through optimization of current therapies.
[Mh] Termos MeSH primário: Ascite/complicações
Ascite/terapia
[Mh] Termos MeSH secundário: Ascite/mortalidade
Dieta Hipossódica
Diuréticos/uso terapêutico
Furosemida/uso terapêutico
Síndrome Hepatorrenal/etiologia
Seres Humanos
Peritonite/etiologia
Prognóstico
Qualidade de Vida
Espironolactona/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Diuretics); 27O7W4T232 (Spironolactone); 7LXU5N7ZO5 (Furosemide)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE


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[PMID]:29220406
[Au] Autor:Okamoto C; Hayakawa Y; Aoyama T; Komaki H; Minatoguchi S; Iwasa M; Yamada Y; Kanamori H; Kawasaki M; Nishigaki K; Mikami A; Minatoguchi S
[Ad] Endereço:Department of Cardiology, Gifu University Graduate School of Medicine, Yanagido, Gifu, Japan.
[Ti] Título:Excessively low salt diet damages the heart through activation of cardiac (pro) renin receptor, renin-angiotensin-aldosterone, and sympatho-adrenal systems in spontaneously hypertensive rats.
[So] Source:PLoS One;12(12):e0189099, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: A high salt intake causes hypertension and leads to cardiovascular disease. Therefore, a low salt diet is now recommended to prevent hypertension and cardiovascular disease. However, it is still unknown whether an excessively low salt diet is beneficial or harmful for the heart. METHODS: Wistar Kyoto rats (WKYs) and spontaneously hypertensive rats (SHRs) received normal salt chow (0.9% salt diet) and excessively low salt chow (0.01% salt diet referred to as saltless diet) for 8 weeks from 8 to 16 weeks of age. The effects of the excessively low salt diet on the cardiac (pro) renin receptor, renin-angiotensin-aldosterone, and sympatho-adrenal systems were investigated. RESULTS: The excessively low salt diet did not affect the systolic blood pressure but significantly increased the heart rate both in WKYs and SHRs. The excessively low salt diet significantly elevated plasma renin activity, plasma angiotensin I, II and aldosterone concentrations, and plasma noradrenaline and adrenaline concentrations both in WKYs and SHRs. Cardiac expressions of renin, prorenin, (P)RR, angiotensinogen, and angiotensin II AT1 receptor and phosphorylated (p)-ERK1/2, p-HSP27, p-38MAPK, and TGF-ß1 were significantly enhanced by the excessively low salt diet in both WKYs and SHRs. The excessively low salt diet accelerated cardiac interstitial and perivascular fibrosis and increased the cardiomyocyte size and interventricular septum thickness in WKYs and SHRs but the extent was greater in SHRs. CONCLUSION: An excessively low salt diet damages the heart through activation of plasma renin-angiotensin-aldosterone and sympatho-adrenal systems and activation of cardiac (P)RR and angiotensin II AT1 receptor and their downstream signals both in WKYs and SHRs.
[Mh] Termos MeSH primário: Aldosterona/metabolismo
Dieta Hipossódica/efeitos adversos
Coração/fisiopatologia
Receptores de Superfície Celular/agonistas
Sistema Renina-Angiotensina/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Ratos
Ratos Endogâmicos SHR
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Cell Surface); 0 (prorenin receptor); 4964P6T9RB (Aldosterone)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189099


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[PMID]:29091561
[Au] Autor:Kalantar-Zadeh K; Fouque D
[Ad] Endereço:From the Harold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California, Irvine, School of Medicine, Orange, the Long Beach Veterans Affairs Healthcare System, Long Beach, the Department of Epidemiology, University of California, Los Angeles (UCLA), and the Los Angeles Biomedical Research Institute at Harbor-UCLA, Torrance - all in California (K.K.-Z.); and the Department of Nephrology, Université Claude Bernard Lyon, Centre Hospitalier Lyon Sud, Cardiometabolism and Nutrition (CarMeN), Lyon, France (D.F.).
[Ti] Título:Nutritional Management of Chronic Kidney Disease.
[So] Source:N Engl J Med;377(18):1765-1776, 2017 Nov 02.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Dieta com Restrição de Proteínas
Dieta Hipossódica
Insuficiência Renal Crônica/dietoterapia
[Mh] Termos MeSH secundário: Acidose/etiologia
Acidose/prevenção & controle
Adulto
Seres Humanos
Necessidades Nutricionais
Insuficiência Renal Crônica/complicações
Insuficiência Renal Crônica/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171102
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMra1700312


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[PMID]:28993451
[Au] Autor:Juraschek SP; Woodward M; Sacks FM; Carey VJ; Miller ER; Appel LJ
[Ad] Endereço:From the Johns Hopkins University School of Medicine, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (S.P.J., M.W., E.R.M., L.J.A.); Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, MD (S.P.J., M.W., E.R.M., L.J.A.); Beth Israel Deaconess Medical Cente
[Ti] Título:Time Course of Change in Blood Pressure From Sodium Reduction and the DASH Diet.
[So] Source:Hypertension;70(5):923-929, 2017 Nov.
[Is] ISSN:1524-4563
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Both sodium reduction and the Dietary Approaches to Stop Hypertension (DASH) diet lower blood pressure (BP); however, the patterns of their effects on BP over time are unknown. In the DASH-Sodium trial, adults with pre-/stage 1 hypertension, not using antihypertensive medications, were randomly assigned to either a typical American diet (control) or DASH. Within their assigned diet, participants randomly ate each of 3 sodium levels (50, 100, and 150 mmol/d, at 2100 kcal) over 4-week periods. BP was measured weekly for 12 weeks; 412 participants enrolled (57% women; 57% black; mean age, 48 years; mean systolic BP [SBP]/diastolic BP [DBP], 135/86 mm Hg). For those assigned control, there was no change in SBP/DBP between weeks 1 and 4 on the high-sodium diet (weekly change, -0.04/0.06 mm Hg/week) versus a progressive decline in BP on the low-sodium diet (-0.94/-0.70 mm Hg/week; interactions between time and sodium <0.001 for SBP and DBP). For those assigned DASH, SBP/DBP changed -0.60/-0.16 mm Hg/week on the high- versus -0.42/-0.54 mm Hg/week on the low-sodium diet ( interactions between time and sodium=0.56 for SBP and 0.10 for DBP). When comparing DASH to control, DASH changed SBP/DBP by -4.36/-1.07 mm Hg after 1 week, which accounted for most of the effect observed, with no significant difference in weekly rates of change for either SBP ( interaction=0.97) or DBP ( interaction=0.70). In the context of a typical American diet, a low-sodium diet reduced BP without plateau, suggesting that the full effects of sodium reduction are not completely achieved by 4 weeks. In contrast, compared with control, DASH lowers BP within a week without further effect thereafter. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00000608.
[Mh] Termos MeSH primário: Pressão Sanguínea
Dieta Hipossódica/métodos
Comportamento Alimentar/fisiologia
Hipertensão
Cloreto de Sódio
[Mh] Termos MeSH secundário: Pressão Sanguínea/efeitos dos fármacos
Pressão Sanguínea/fisiologia
Determinação da Pressão Arterial/métodos
Feminino
Seres Humanos
Hipertensão/diagnóstico
Hipertensão/dietoterapia
Hipertensão/fisiopatologia
Hipertensão/psicologia
Masculino
Meia-Idade
Monitorização Fisiológica/métodos
Avaliação de Resultados (Cuidados de Saúde)
Gravidade do Paciente
Cloreto de Sódio/efeitos adversos
Cloreto de Sódio/farmacocinética
Fatores de Tempo
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
451W47IQ8X (Sodium Chloride)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171029
[Lr] Data última revisão:
171029
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171011
[St] Status:MEDLINE
[do] DOI:10.1161/HYPERTENSIONAHA.117.10017


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[PMID]:28974570
[Au] Autor:Selvarajah V; Mäki-Petäjä KM; Pedro L; Bruggraber SFA; Burling K; Goodhart AK; Brown MJ; McEniery CM; Wilkinson IB
[Ad] Endereço:From the Division of Experimental Medicine and Immunotherapeutics, University of Cambridge, United Kingdom (V.S., K.M.M-P., A.K.G., C.M.M., I.B.W.); MRC Human Nutrition Unit, Cambridge, United Kingdom (L.P., S.F.A.B.); NIHR Cambridge Biomedical Research Centre, Core Biochemical Assay Laboratory, Uni
[Ti] Título:Novel Mechanism for Buffering Dietary Salt in Humans: Effects of Salt Loading on Skin Sodium, Vascular Endothelial Growth Factor C, and Blood Pressure.
[So] Source:Hypertension;70(5):930-937, 2017 Nov.
[Is] ISSN:1524-4563
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:High dietary sodium intake triggers increased blood pressure (BP). Animal studies show that dietary salt loading results in dermal Na accumulation and lymphangiogenesis mediated by VEGF-C (vascular endothelial growth factor C), both attenuating the rise in BP. Our objective was to determine whether these mechanisms function in humans. We assessed skin electrolytes, BP, and plasma VEGF-C in 48 healthy participants randomized to placebo (70 mmol sodium/d) and slow sodium (200 mmol/d) for 7 days. Skin Na and K concentrations were measured in mg/g of wet tissue and expressed as the ratio Na :K to correct for variability in sample hydration. Skin Na :K increased between placebo and slow sodium phases (2.91±0.08 versus 3.12±0.09; =0.01). In post hoc analysis, there was a suggestion of a sex-specific effect, with a significant increase in skin Na :K in men (2.59±0.09 versus 2.88±0.12; =0.008) but not women (3.23±0.10 versus 3.36±0.12; =0.31). Women showed a significant increase in 24-hour mean BP with salt loading (93±1 versus 91±1 mm Hg; <0.001) while men did not (96±2 versus 96±2 mm Hg; =0.91). Skin Na :K correlated with BP, stroke volume, and peripheral vascular resistance in men but not in women. No change was noted in plasma VEGF-C. These findings suggest that the skin may buffer dietary Na , reducing the hemodynamic consequences of increased salt, and this may be influenced by sex.
[Mh] Termos MeSH primário: Dieta Hipossódica/métodos
Hipertensão
Potássio
Pele/metabolismo
Cloreto de Sódio
Sódio
Fator C de Crescimento do Endotélio Vascular/sangue
[Mh] Termos MeSH secundário: Adulto
Pressão Sanguínea/efeitos dos fármacos
Pressão Sanguínea/fisiologia
Método Duplo-Cego
Inglaterra
Feminino
Hemodinâmica/fisiologia
Seres Humanos
Hipertensão/diagnóstico
Hipertensão/dietoterapia
Hipertensão/metabolismo
Masculino
Meia-Idade
Potássio/análise
Potássio/metabolismo
Eliminação Renal/fisiologia
Fatores Sexuais
Sódio/análise
Sódio/metabolismo
Cloreto de Sódio/metabolismo
Cloreto de Sódio/farmacologia
Equilíbrio Hidroeletrolítico/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Vascular Endothelial Growth Factor C); 451W47IQ8X (Sodium Chloride); 9NEZ333N27 (Sodium); RWP5GA015D (Potassium)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171005
[St] Status:MEDLINE
[do] DOI:10.1161/HYPERTENSIONAHA.117.10003


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[PMID]:28855223
[Au] Autor:Derkach A; Sampson J; Joseph J; Playdon MC; Stolzenberg-Solomon RZ
[Ad] Endereço:Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD; and.
[Ti] Título:Effects of dietary sodium on metabolites: the Dietary Approaches to Stop Hypertension (DASH)-Sodium Feeding Study.
[So] Source:Am J Clin Nutr;106(4):1131-1141, 2017 Oct.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:High sodium intake is known to increase blood pressure and is difficult to measure in epidemiologic studies. We examined the effect of sodium intake on metabolites within the DASH (Dietary Approaches to Stop Hypertension Trial)-Sodium Trial to further our understanding of the biological effects of sodium intake beyond blood pressure. The DASH-Sodium Trial randomly assigned individuals to either the DASH diet (low in fat and high in protein, low-fat dairy, and fruits and vegetables) or a control diet for 12 wk. Participants within each diet arm received, in random order, diets containing high (150 nmol or 3450 mg), medium (100 nmol or 2300 mg), and low (50 nmol or 1150 mg) amounts of sodium for 30 d (crossover design). Fasting blood samples were collected at the end of each sodium intervention. We measured 531 identified plasma metabolites in 73 participants at the end of their high- and low-sodium interventions and in 46 participants at the end of their high- and medium-sodium interventions ( = 119). We used linear mixed-effects regression to model the relation between each log-transformed metabolite and sodium intake. We also combined the resulting values with Fisher's method to estimate the association between sodium intake and 38 metabolic pathways or groups. Six pathways were associated with sodium intake at a Bonferroni-corrected threshold of 0.0013 (e.g., fatty acid, food component or plant, benzoate, γ-glutamyl amino acid, methionine, and tryptophan). Although 82 metabolites were associated with sodium intake at a false discovery rate ≤0.10, only 4-ethylphenylsufate, a xenobiotic related to benzoate metabolism, was significant at a Bonferroni-corrected threshold ( < 10 ). Adjustment for coinciding change in blood pressure did not substantively alter the association for the top-ranked metabolites. Sodium intake is associated with changes in circulating metabolites, including gut microbial, tryptophan, plant component, and γ-glutamyl amino acid-related metabolites. This trial was registered at clinicaltrials.gov as NCT00000608.
[Mh] Termos MeSH primário: Dieta
Comportamento Alimentar
Hipertensão/sangue
Metaboloma/efeitos dos fármacos
Cloreto de Sódio na Dieta/farmacologia
Sódio na Dieta/farmacologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Aminoácidos/sangue
Pressão Sanguínea
Estudos Cross-Over
Dieta com Restrição de Carboidratos
Dieta com Restrição de Gorduras
Dieta Hipossódica
Feminino
Frutas
Microbioma Gastrointestinal
Seres Humanos
Hipertensão/dietoterapia
Masculino
Redes e Vias Metabólicas/efeitos dos fármacos
Meia-Idade
Extratos Vegetais/sangue
Cloreto de Sódio na Dieta/administração & dosagem
Sódio na Dieta/administração & dosagem
Verduras
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Amino Acids); 0 (Plant Extracts); 0 (Sodium Chloride, Dietary); 0 (Sodium, Dietary)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.150136


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[PMID]:28800936
[Au] Autor:Ware LJ; Charlton K; Schutte AE; Cockeran M; Naidoo N; Kowal P
[Ad] Endereço:Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa. Electronic address: lisa.jayne.ware@gmail.com.
[Ti] Título:Associations between dietary salt, potassium and blood pressure in South African adults: WHO SAGE Wave 2 Salt & Tobacco.
[So] Source:Nutr Metab Cardiovasc Dis;27(9):784-791, 2017 Sep.
[Is] ISSN:1590-3729
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND & AIMS: In June 2016, South Africa implemented legislation mandating maximum sodium levels in a range of processed foods with a goal of reducing population salt intake and disease burden from hypertension. Our aim was to explore the relationship between salt and blood pressure (BP) in a subsample of the World Health Organization Study on global AGEing and adult health (SAGE) Wave 2 before implementation of legislation in South Africa. METHODS & RESULTS: Blood pressure (BP) was measured in triplicate (n = 2722; median age 56 years; 33% male) and 24-h urine collected in a nested subsample (n = 526) for sodium, potassium and creatinine analysis. Hypertension prevalence was 55% in older adults (50-plus years) and 28% in younger adults (18-49 years). Median salt intake (6.8 g/day) was higher in younger than older adults (8.6 g vs 6.1 g/day; p < 0.001), and in urban compared to rural populations (7.0 g vs 6.0 g/day; p = 0.033). Overall, 69% of participants had salt intakes above 5 g/day. Potassium intakes were generally low (median 35 mmol/day) with significantly lower intakes in rural areas and older adults. Overall, 91% of adults failed to meet the daily potassium recommendation of 90 mmol/d. Salt intakes above 5 g/day, and to a greater extent, a dietary sodium-to-potassium (Na:K) ratio above 2 mmol/mmol, were associated with significantly steeper regression slopes of BP with age. CONCLUSION: These preliminary results indicate that high dietary Na:K ratio may lead to a greater increase in BP and hypertension risk with age. Interventions to increase potassium intakes alongside sodium reduction initiatives may be warranted.
[Mh] Termos MeSH primário: Pressão Sanguínea
Hipertensão/epidemiologia
Deficiência de Potássio/epidemiologia
Potássio na Dieta/administração & dosagem
Sódio na Dieta/efeitos adversos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Distribuição por Idade
Idoso
Dieta Hipossódica
Feminino
Nível de Saúde
Seres Humanos
Hipertensão/diagnóstico
Hipertensão/fisiopatologia
Hipertensão/prevenção & controle
Modelos Lineares
Masculino
Meia-Idade
Deficiência de Potássio/diagnóstico
Deficiência de Potássio/urina
Potássio na Dieta/urina
Prevalência
Fatores de Proteção
Recomendações Nutricionais
Medição de Risco
Fatores de Risco
Comportamento de Redução do Risco
Saúde da População Rural
Sódio na Dieta/urina
África do Sul/epidemiologia
Saúde da População Urbana
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Potassium, Dietary); 0 (Sodium, Dietary)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170813
[St] Status:MEDLINE


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[PMID]:28719636
[Au] Autor:Alshahrani S; Rapoport RM; Zahedi K; Jiang M; Nieman M; Barone S; Meredith AL; Lorenz JN; Rubinstein J; Soleimani M
[Ad] Endereço:Department of Pharmacology and Cell Biophysics, University of Cincinnati, College of Medicine, Cincinnati, OH, United States of America.
[Ti] Título:The non-diuretic hypotensive effects of thiazides are enhanced during volume depletion states.
[So] Source:PLoS One;12(7):e0181376, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Thiazide derivatives including Hydrochlorothiazide (HCTZ) represent the most common treatment of mild to moderate hypertension. Thiazides initially enhance diuresis via inhibition of the kidney Na+-Cl- Cotransporter (NCC). However, chronic volume depletion and diuresis are minimal while lowered blood pressure (BP) is maintained on thiazides. Thus, a vasodilator action of thiazides is proposed, likely via Ca2+-activated K+ (BK) channels in vascular smooth muscles. This study ascertains the role of volume depletion induced by salt restriction or salt wasting in NCC KO mice on the non-diuretic hypotensive action of HCTZ. HCTZ (20mg/kg s.c.) lowered BP in 1) NCC KO on a salt restricted diet but not with normal diet; 2) in volume depleted but not in volume resuscitated pendrin/NCC dKO mice; the BP reduction occurs without any enhancement in salt excretion or reduction in cardiac output. HCTZ still lowered BP following treatment of NCC KO on salt restricted diet with paxilline (8 mg/kg, i.p.), a BK channel blocker, and in BK KO and BK/NCC dKO mice on salt restricted diet. In aortic rings from NCC KO mice on normal and low salt diet, HCTZ did not alter and minimally decreased maximal phenylephrine contraction, respectively, while contractile sensitivity remained unchanged. These results demonstrate 1) the non-diuretic hypotensive effects of thiazides are augmented with volume depletion and 2) that the BP reduction is likely the result of HCTZ inhibition of vasoconstriction through a pathway dependent on factors present in vivo, is unrelated to BK channel activation, and involves processes associated with intravascular volume depletion.
[Mh] Termos MeSH primário: Anti-Hipertensivos/farmacologia
Hidroclorotiazida/farmacologia
Hipovolemia/fisiopatologia
[Mh] Termos MeSH secundário: Antagonistas de Receptores de Angiotensina/farmacologia
Animais
Pressão Sanguínea/efeitos dos fármacos
Débito Cardíaco/efeitos dos fármacos
Dieta Hipossódica
Hipovolemia/metabolismo
Canais de Potássio Ativados por Cálcio de Condutância Alta/metabolismo
Camundongos
Receptores de Angiotensina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiotensin Receptor Antagonists); 0 (Antihypertensive Agents); 0 (Large-Conductance Calcium-Activated Potassium Channels); 0 (Receptors, Angiotensin); 0J48LPH2TH (Hydrochlorothiazide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181376


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[PMID]:28577665
[Au] Autor:Neal B; Tian M; Li N; Elliott P; Yan LL; Labarthe DR; Huang L; Yin X; Hao Z; Stepien S; Shi J; Feng X; Zhang J; Zhang Y; Zhang R; Wu Y
[Ad] Endereço:The George Institute for Global Health and Charles Perkins Centre, University of Sydney, Sydney, Australia; Imperial College London, London, United Kingdom. Electronic address: bneal@georgeinstitute.org.au.
[Ti] Título:Rationale, design, and baseline characteristics of the Salt Substitute and Stroke Study (SSaSS)-A large-scale cluster randomized controlled trial.
[So] Source:Am Heart J;188:109-117, 2017 Jun.
[Is] ISSN:1097-6744
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lowering sodium intake with a reduced-sodium, added potassium salt substitute has been proved to lower blood pressure levels. Whether the same strategy will also reduce the risks of vascular outcomes is uncertain and controversial. The SSaSS has been designed to test whether sodium reduction achieved with a salt substitute can reduce the risk of vascular disease. The study is a large-scale, open, cluster-randomized controlled trial done in 600 villages across 5 provinces in China. Participants have either a history of stroke or an elevated risk of stroke based on age and blood pressure level at entry. Villages were randomized in a 1:1 ratio to intervention or continued usual care. Salt substitute is provided free of charge to participants in villages assigned to the intervention group. Follow-up is scheduled every 6months for 5years, and all potential endpoints are reviewed by a masked adjudication committee. The primary end point is fatal and nonfatal stroke, and the 2 secondary endpoints are total major cardiovascular events and total mortality. The study has been designed to provide 90% statistical power (with 2-sided α = .05) to detect a 13% or greater relative risk reduction for stroke. The power estimate assumes a primary outcome event rate of 3.5% per year and a systolic blood pressure difference of 3.0mm Hg between randomized groups. Recruitment is complete and there are 20,996 participants (about 35 per village) that have been enrolled. Mean age is 65years and 49% are female. There were 73% enrolled on the basis of a history of stroke. The trial is well placed to describe the effects of salt substitution on the risks of vascular disease and death and will provide important policy-relevant data.
[Mh] Termos MeSH primário: Pressão Sanguínea/fisiologia
Dieta Hipossódica/métodos
Hipertensão/dietoterapia
Potássio/administração & dosagem
Medição de Risco/métodos
Acidente Vascular Cerebral/prevenção & controle
[Mh] Termos MeSH secundário: Idoso
Pressão Sanguínea/efeitos dos fármacos
China/epidemiologia
Feminino
Seguimentos
Seres Humanos
Hipertensão/complicações
Hipertensão/fisiopatologia
Incidência
Masculino
Estudos Retrospectivos
Fatores de Risco
Acidente Vascular Cerebral/epidemiologia
Acidente Vascular Cerebral/etiologia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
RWP5GA015D (Potassium)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170605
[St] Status:MEDLINE


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[PMID]:28551253
[Au] Autor:Bernklau I; Neußer C; Moroni AV; Gysler C; Spagnolello A; Chung W; Jekle M; Becker T
[Ad] Endereço:Technical University of Munich, Institute of Brewing and Beverage Technology, Research Group Cereal Technology and Process Engineering, 85354 Freising, Germany.
[Ti] Título:Structural, textural and sensory impact of sodium reduction on long fermented pizza.
[So] Source:Food Chem;234:398-407, 2017 Nov 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to elucidate the microstructural, textural, and sensory impact of sodium reduction and its partial replacement by potassium chloride in pizza dough and crusts prepared by a traditional long fermentation process. For the first time, macrostructural changes in texture were elucidated and quantified by a novel protein network analysis. The fermentation process exerted a strengthening effect in the doughs, allowing to reduce sodium up to 25% without any negative impact on texture. Sodium reduction by 15% did not cause any significant textural changes in pizza crusts and partial replacement by KCl resulted in a strengthened dough and firmer pizza crust. The use of toppings masked the effect of lowering the sodium content, allowing to increase the reduction level from 15% to 35%. A reduction of NaCl by 25% with an addition of KCl achieved high acceptance in the sensory evaluation.
[Mh] Termos MeSH primário: Dieta Hipossódica
Análise de Alimentos
Sódio/análise
[Mh] Termos MeSH secundário: Pão/análise
Fermentação
Preferências Alimentares
Qualidade dos Alimentos
Seres Humanos
Cloreto de Potássio
Cloreto de Sódio
Paladar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
451W47IQ8X (Sodium Chloride); 660YQ98I10 (Potassium Chloride); 9NEZ333N27 (Sodium)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170810
[Lr] Data última revisão:
170810
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170529
[St] Status:MEDLINE



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