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Pesquisa : E02.642.249.300.500 [Categoria DeCS]
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[PMID]:28285645
[Au] Autor:Soare A; Khazrai YM; Fontana L; Del Toro R; Lazzaro MC; Di Rosa C; Buldo A; Fioriti E; Maddaloni E; Angeletti S; Di Mauro A; Gesuita R; Skrami E; Tuccinardi D; Fallucca S; Pianesi M; Pozzilli P
[Ad] Endereço:Unit of Endocrinology and Diabetes, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
[Ti] Título:Treatment of reactive hypoglycemia with the macrobiotic Ma-pi 2 diet as assessed by continuous glucose monitoring: The MAHYP randomized crossover trial.
[So] Source:Metabolism;69:148-156, 2017 Apr.
[Is] ISSN:1532-8600
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIMS: Nutritional therapy is recommended for management of reactive hypoglycemia (RH), a condition characterized by hypoglycemia that occurs within four hours after a meal. The macrobiotic Ma-Pi 2 diet improves glycemic control in subjects with type 2 diabetes. We explored the effect of this diet on outcomes in non-diabetic individuals with RH. MATERIALS AND METHODS: Twelve subjects with RH were randomized to the Ma-Pi 2 diet for three days and a control diet for three days in a randomized crossover design. Subjects received snacks on two days out of each three-day period only, and were monitored using continuous glucose monitoring. The 24-h period was divided into daytime (08:00-22:30h [subdivided into 'daytime without snacks' and 'daytime with snacks']) and night-time (22:31-07:59h). The effects of the two diets on the number of RH events (blood glucose <70mg/dL [3.9mmol/L]) and the percentage distribution of glucose readings within each of 16 glycemic intervals from <40mg/dL (2.2mmol/L) to >180mg/dL (4.4mmol/L) were determined. RESULTS: There were significantly fewer RH events on the Ma-Pi 2 diet than the control diet during daytime without snacks (-2.5 events; 95% CI: -7.5, 0.0; P=0.022) and daytime with snacks (-4.25 events; 95% CI: -7.5; -2.0; P=0.013) but no difference at night. The percentage of glucose readings in the interval 71-80mg/dL (3.9-4.4mmol/L) was significantly higher on the control diet during daytime with and without snacks (P=0.03 for both), while the percentage of glucose readings in the interval 91-100mg/dL (5.1-5.6mmol/L) was significantly higher on the Ma-Pi 2 diet during daytime without snacks (P=0.02). CONCLUSIONS: The macrobiotic Ma-Pi 2 diet reduced blood glucose excursions during the day, thereby facilitating glycemic control in subjects with RH. The Ma-Pi 2 diet represents an effective nutritional tool for management of RH.
[Mh] Termos MeSH primário: Glicemia/análise
Dieta Macrobiótica
Hipoglicemia/dietoterapia
[Mh] Termos MeSH secundário: Adulto
Automonitorização da Glicemia
Índice de Massa Corporal
Peso Corporal
Estudos Cross-Over
Feminino
Seres Humanos
Masculino
Meia-Idade
Lanches
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Blood Glucose)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170314
[St] Status:MEDLINE


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[PMID]:27151248
[Au] Autor:Candela M; Biagi E; Soverini M; Consolandi C; Quercia S; Severgnini M; Peano C; Turroni S; Rampelli S; Pozzilli P; Pianesi M; Fallucca F; Brigidi P
[Ad] Endereço:1Department of Pharmacy and Biotechnology,University of Bologna,40126 Bologna,Italy.
[Ti] Título:Modulation of gut microbiota dysbioses in type 2 diabetic patients by macrobiotic Ma-Pi 2 diet.
[So] Source:Br J Nutr;116(1):80-93, 2016 Jul.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The gut microbiota exerts a role in type 2 diabetes (T2D), and deviations from a mutualistic ecosystem layout are considered a key environmental factor contributing to the disease. Thus, the possibility of improving metabolic control in T2D by correcting gut microbiome dysbioses through diet has been evaluated. Here, we explore the potential of two different energy-restricted dietary approaches - the fibre-rich macrobiotic Ma-Pi 2 diet or a control diet recommended by Italian professional societies for T2D treatment - to correct gut microbiota dysbioses in T2D patients. In a previous 21-d open-label MADIAB trial, fifty-six overweight T2D patients were randomised to the Ma-Pi 2 or the control diet. For the present study, stools were collected before and after intervention from a subset of forty MADIAB participants, allowing us to characterise the gut microbiota by 16S rRNA sequencing and imputed metagenomics. To highlight microbiota dysbioses in T2D, the gut microbiota of thirteen normal-weight healthy controls were characterised. According to our findings, both diets were effective in modulating gut microbiome dysbioses in T2D, resulting in an increase of the ecosystem diversity and supporting the recovery of a balanced community of health-promoting SCFA producers, such as Faecalibacterium, Roseburia, Lachnospira, Bacteroides and Akkermansia. The Ma-Pi 2 diet, but not the control diet, was also effective in counteracting the increase of possible pro-inflammatory groups, such as Collinsella and Streptococcus, in the gut ecosystem, showing the potential to reverse pro-inflammatory dysbioses in T2D, and possibly explaining the greater efficacy in improving the metabolic control.
[Mh] Termos MeSH primário: Bactérias/classificação
Diabetes Mellitus Tipo 2/microbiologia
Dieta Macrobiótica
Intestinos/microbiologia
Microbiota
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Sobrepeso
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170508
[Lr] Data última revisão:
170508
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160507
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114516001045


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[PMID]:27071584
[Au] Autor:Lechner K; Parhofer KG
[Ad] Endereço:Klinikum der Universität München Medizinische Klinik und Poliklinik II - Großhadern, Marchioninistraße 15, D-81377, München, Deutschland.
[Ti] Título:[Dietary advice for preventing and treating T2DM: A shift of paradigm].
[Ti] Título:So steuern Sie das Essverhalten Ihrer Patienten in die richtige Richtung..
[So] Source:MMW Fortschr Med;158(7):41-4, 2016 Apr 14.
[Is] ISSN:1438-3276
[Cp] País de publicação:Germany
[La] Idioma:ger
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/dietoterapia
Diabetes Mellitus Tipo 2/prevenção & controle
Dieta para Diabéticos
Dieta Macrobiótica
Gorduras na Dieta/administração & dosagem
[Mh] Termos MeSH secundário: Colesterol na Dieta/administração & dosagem
Dieta com Restrição de Carboidratos
Seres Humanos
Síndrome Metabólica/dietoterapia
Síndrome Metabólica/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cholesterol, Dietary); 0 (Dietary Fats)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160414
[St] Status:MEDLINE
[do] DOI:10.1007/s15006-016-8060-0


  4 / 55 MEDLINE  
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[PMID]:26212923
[Au] Autor:Harmon BE; Carter M; Hurley TG; Shivappa N; Teas J; Hébert JR
[Ad] Endereço:a Division of Social and Behavioral Sciences, School of Public Health, University of Memphis , Memphis , Tennessee , USA.
[Ti] Título:Nutrient Composition and Anti-inflammatory Potential of a Prescribed Macrobiotic Diet.
[So] Source:Nutr Cancer;67(6):933-40, 2015.
[Is] ISSN:1532-7914
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite nutrient adequacy concerns, macrobiotic diets are practiced by many individuals with cancer and other life-threatening illnesses. This study compared the nutrient composition and inflammatory potential of a macrobiotic diet plan with national dietary recommendations and intakes from a nationally representative sample. Nutrient comparisons were made using the 1) macrobiotic diet plan outlined in the Kushi Institute's Way to Health; 2) recommended dietary allowances (RDA); and 3) National Health and Nutrition Examination Survey (NHANES) 2009-2010 data. Comparisons included application of the recently developed dietary inflammatory index (DII). Analyses focused on total calories, macronutrients, 28 micronutrients, and DII scores. Compared to NHANES data, the macrobiotic diet plan had a lower percentage of energy from fat, higher total dietary fiber, and higher amounts of most micronutrients. Nutrients often met or exceeded RDA recommendations, except for vitamin D, vitamin B12, and calcium. Based on DII scores, the macrobiotic diet was more anti-inflammatory compared to NHANES data (average scores of -1.88 and 1.00, respectively). Findings from this analysis of a macrobiotic diet plan indicate the potential for disease prevention and suggest the need for studies of real-world consumption as well as designing, implementing, and testing interventions based on the macrobiotic approach.
[Mh] Termos MeSH primário: Dieta Macrobiótica
Valor Nutritivo
[Mh] Termos MeSH secundário: Adulto
Biomarcadores/sangue
Dieta Ocidental
Fibras na Dieta/administração & dosagem
Ingestão de Energia
Feminino
Seres Humanos
Masculino
Micronutrientes/administração & dosagem
Meia-Idade
Inquéritos Nutricionais
Recomendações Nutricionais
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Biomarkers); 0 (Dietary Fiber); 0 (Micronutrients)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150728
[St] Status:MEDLINE
[do] DOI:10.1080/01635581.2015.1055369


  5 / 55 MEDLINE  
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[PMID]:25400068
[Au] Autor:Fallucca F; Fallucca S; Pianesi M
[Ad] Endereço:'In Unam Sapientiam' Foundation, University La Sapienza, Rome, Italy.
[Ti] Título:The effects of the MA-PI 2 macrobiotic diet in the treatment of type 2 diabetes and diet-induced metabolic acidosis.
[So] Source:Diabetes Metab Res Rev;30(8):659-60, 2014 Nov.
[Is] ISSN:1520-7560
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/dietoterapia
Dieta Macrobiótica
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:COMMENT; LETTER
[Em] Mês de entrada:1505
[Cu] Atualização por classe:141117
[Lr] Data última revisão:
141117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141118
[St] Status:MEDLINE
[do] DOI:10.1002/dmrr.2602


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[PMID]:24532293
[Au] Autor:Porrata-Maury C; Hernández-Triana M; Ruiz-Álvarez V; Díaz-Sánchez ME; Fallucca F; Bin W; Baba-Abubakari B; Pianesi M
[Ad] Endereço:Finlay Institute, Havana, Cuba.
[Ti] Título:Ma-Pi 2 macrobiotic diet and type 2 diabetes mellitus: pooled analysis of short-term intervention studies.
[So] Source:Diabetes Metab Res Rev;30 Suppl 1:55-66, 2014 Mar.
[Is] ISSN:1520-7560
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The macrobiotic, Ma-Pi 2 diet (12% protein, 18% fat and 70% carbohydrate), has shown benefit in adults with type 2 diabetes mellitus (T2DM). This pooled analysis aims to confirm results from four, 21-day intervention studies with the Ma-Pi 2 diet, carried out in Cuba, China, Ghana and Italy. Baseline and end of study biochemical, body composition and blood pressure data, were compared using multivariate statistical methods and assessment of the Cohen effect size (d). Results showed that all measured indicators demonstrated significant changes (p < 0.001); most of them with a very high (d ≥ 1.30), or high (d = 0.80-1.29) effect size. The global effect size of the diet was Italy (1.96), China (1.79), Cuba (1.38) and Ghana (0.98). The magnitude of the individual effect on each variable by country, and the global effect by country, was independent of the sample size (p > 0.05). Similarly, glycemia and glycemic profiles in all four studies were independent of the sample size (p = 0.237). The Ma-Pi diet 2 significantly reduced glycemia, serum lipids, uremia and cardiovascular risk in adults with T2DM. These results suggest that the Ma-Pi 2 diet could be a valid alternative treatment for patients with T2DM and point to the need for further clinical studies. Mechanisms related to its benefits as a functional diet are discussed.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/dietoterapia
Dieta Macrobiótica
[Mh] Termos MeSH secundário: Glicemia/metabolismo
Doenças Cardiovasculares/prevenção & controle
China
Cuba
Carboidratos da Dieta
Gorduras na Dieta
Gana
Seres Humanos
Itália
Lipídeos/sangue
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Dietary Carbohydrates); 0 (Dietary Fats); 0 (Lipids)
[Em] Mês de entrada:1410
[Cu] Atualização por classe:150102
[Lr] Data última revisão:
150102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140218
[St] Status:MEDLINE
[do] DOI:10.1002/dmrr.2519


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[PMID]:24532292
[Au] Autor:Fallucca F; Porrata C; Fallucca S; Pianesi M
[Ad] Endereço:University La Sapienza, Rome, Italy.
[Ti] Título:Influence of diet on gut microbiota, inflammation and type 2 diabetes mellitus. First experience with macrobiotic Ma-Pi 2 diet.
[So] Source:Diabetes Metab Res Rev;30 Suppl 1:48-54, 2014 Mar.
[Is] ISSN:1520-7560
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Type 2 diabetes mellitus (T2DM) is a complex disorder influenced by both genetic and environmental factors. Recent studies have suggested that an imbalance of the intestinal microbiota may be involved in the development of several human diseases, including obesity and T2DM. The main regulators of the intestinal microbiota are age, ethnicity, the immune system and diet. A high-fat diet may induce dysbiosis, which can result in a low-grade inflammatory state, obesity and other metabolic disorders. Adding prebiotics to the diet may reduce inflammation, endotoxaemia and cytokine levels as well as improving insulin resistance and glucose tolerance. The administration of prebiotics such as fermentable dietary fibres, promotes glucagon-like peptide 1 and peptide YY (anorexigenic) and decreases ghrelin (orexigenic). In a recent 21-day, intervention study in patients with T2DM, the effect of using the macrobiotic Ma-Pi 2 diet was investigated. Results suggested that it could induce a significant improvement in fasting blood glucose, plasma lipid fractions, plasma insulin and homeostasis. It is therefore possible that a diet rich in prebiotics and probiotics can play a role in T2DM management, probably due to positive intestinal microbiota modulation. However, this must be demonstrated by larger studies including randomized controlled trials that measure indicators of inflammation.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/dietoterapia
Dieta Macrobiótica
Trato Gastrointestinal/microbiologia
[Mh] Termos MeSH secundário: Dieta
Dieta Hiperlipídica
Disbiose/fisiopatologia
Endotoxemia/complicações
Seres Humanos
Inflamação/etiologia
Microbiota
Obesidade/dietoterapia
Prebióticos/microbiologia
Probióticos/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Prebiotics)
[Em] Mês de entrada:1410
[Cu] Atualização por classe:140217
[Lr] Data última revisão:
140217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140218
[St] Status:MEDLINE
[do] DOI:10.1002/dmrr.2518


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[PMID]:24575630
[Au] Autor:Milankov O
[Ti] Título:[Macrobiotics-life in harmony with the universe].
[Ti] Título:Makrobiotika - Zvot u skladu sa univerzumom..
[So] Source:Med Pregl;66(11-12):443-7, 2013 Nov-Dec.
[Is] ISSN:0025-8105
[Cp] País de publicação:Serbia
[La] Idioma:hrv
[Mh] Termos MeSH primário: Dieta Macrobiótica
[Mh] Termos MeSH secundário: Pré-Escolar
Grãos Comestíveis
Frutas
Seres Humanos
Verduras
[Pt] Tipo de publicação:EDITORIAL
[Em] Mês de entrada:1508
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140301
[St] Status:MEDLINE


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[PMID]:22869285
[Au] Autor:Villarini A; Pasanisi P; Raimondi M; Gargano G; Bruno E; Morelli D; Evangelista A; Curtosi P; Berrino F
[Ad] Endereço:Department of Predictive & Preventive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Via Venezian, 1, 20133 Milano, Italy.
[Ti] Título:Preventing weight gain during adjuvant chemotherapy for breast cancer: a dietary intervention study.
[So] Source:Breast Cancer Res Treat;135(2):581-9, 2012 Sep.
[Is] ISSN:1573-7217
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Adjuvant chemotherapy significantly decreases recurrences and improves survival in women with early breast cancer (BC). However, the side effects of chemotherapy include weight gain, which is associated with poorer prognosis. We have previously demonstrated that by means of a comprehensive dietary modification which aims at lowering insulin levels it is possible to reduce body weight and decrease the bioavailability of insulin, sex hormones and the growth factors linked to BC risk and prognosis. We are now going to present a randomized controlled study of adjuvant diet in BC patients undergoing chemotherapy. The diet was designed to prevent weight gain during chemotherapy treatment. Women of any age, operated for invasive BC, scheduled for adjuvant chemotherapy and without evidence of distant metastases, were randomized into a dietary intervention group and a control group. The intervention implied changing their usual diet for the whole duration of chemotherapy, following cooking classes and having lunch or dinner at the study centre at least twice per week. 96 BC patients were included in the study. The women in the intervention group showed a significant reduction in their body weight (2.9 kg on average), compared with the controls. They also significantly reduced body fat mass, waist and hip circumferences, biceps, underscapular and suprailiac skinfolds, compared with the women in the control group. Our results support the hypothesis that dietary intervention during adjuvant chemotherapy for BC is feasible and may prevent weight gain.
[Mh] Termos MeSH primário: Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos
Neoplasias da Mama/terapia
Carcinoma Ductal de Mama/terapia
Sobrepeso/dietoterapia
Ganho de Peso/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adulto
Antraciclinas/administração & dosagem
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Quimioterapia Adjuvante/efeitos adversos
Ciclofosfamida/administração & dosagem
Dieta Macrobiótica
Dieta Mediterrânea
Feminino
Fluoruracila/administração & dosagem
Seres Humanos
Metotrexato/administração & dosagem
Meia-Idade
Sobrepeso/induzido quimicamente
Sobrepeso/prevenção & controle
Taxoides/administração & dosagem
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anthracyclines); 0 (Taxoids); 8N3DW7272P (Cyclophosphamide); U3P01618RT (Fluorouracil); YL5FZ2Y5U1 (Methotrexate)
[Em] Mês de entrada:1301
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120808
[St] Status:MEDLINE
[do] DOI:10.1007/s10549-012-2184-4


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[PMID]:21199264
[Au] Autor:Gallen IW; Hume C; Lumb A
[Ad] Endereço:Diabetes Centre, Wycombe Hospital, High Wycombe, Buckinghamshire HP11 2TT, UK. ian.gallen@buckshosp.nhs.uk
[Ti] Título:Fuelling the athlete with type 1 diabetes.
[So] Source:Diabetes Obes Metab;13(2):130-6, 2011 Feb.
[Is] ISSN:1463-1326
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:People with type 1 diabetes (T1DM) want to enjoy the benefits of sport and exercise, but management of diabetes in this context is complex. An understanding of the physiology of exercise in health, and particularly the control of fuel mobilization and metabolism, gives an idea of problems which may arise in managing diabetes for sport and exercise. Athletes with diabetes need to be advised on appropriate diet to maximize performance and reduce fatigue. Exercise in diabetes is complicated both by hypoglycaemia and hyperglycaemia in particular circumstances and explanations are advanced which can provide a theoretical underpinning for possible management strategies. Management strategies are proposed to improve glycaemic control and performance.
[Mh] Termos MeSH primário: Atletas
Diabetes Mellitus Tipo 1/dietoterapia
Hiperglicemia/prevenção & controle
Hipoglicemia/prevenção & controle
Insulina/uso terapêutico
[Mh] Termos MeSH secundário: Diabetes Mellitus Tipo 1/tratamento farmacológico
Dieta para Diabéticos
Dieta Macrobiótica
Feminino
Seres Humanos
Hiperglicemia/complicações
Hipoglicemia/complicações
Masculino
Atividade Motora/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Insulin)
[Em] Mês de entrada:1105
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110105
[St] Status:MEDLINE
[do] DOI:10.1111/j.1463-1326.2010.01319.x



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