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[PMID]:29465559
[Au] Autor:Zhang Y; Cao H; Jiang P; Tang H
[Ad] Endereço:Department of Geriatrics Cardiology.
[Ti] Título:Cardiac rehabilitation in acute myocardial infarction patients after percutaneous coronary intervention: A community-based study.
[So] Source:Medicine (Baltimore);97(8):e9785, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Acute myocardial infarction (AMI) is one of the leading causes of death and physical disability worldwide. However, the development of community- based cardiac rehabilitation (CR) in AMI patients is hysteretic. Here, we aimed to evaluate the safety and efficacy of CR applied in the community in AMI patients who underwent percutaneous coronary intervention (PCI). METHODS: A total of 130 ST-segment elevated myocardial infarction (STEMI) patients after PCI were randomly divided into 2 groups in the community, rehabilitation group (n = 65) and control group (n = 65). Cardiac function, a 6-minute walk distance, exercise time and steps, cardiovascular risk factors were monitored respectively and compared before and after the intervention of 2 groups. The software of EpiData 3.1 was used to input research data and SPSS16.0 was used for statistical analysis. RESULTS: After a planned rehabilitation intervention, the rehabilitation group showed better results than the control group. The rehabilitation group had a significant improvement in recurrence angina and readmission (P < .01). Left ventricular ejection fraction (LVEF) of rehabilitation group showed improvement in phase II (t = 4.963, P < .01) and phase III (t = 11.802, P < .01), and the New York Heart Association (NYHA) classification was recovered within class II. There was a significant difference compared with before (Z = 7.238, P < .01). Six minutes walking distance, aerobic exercise time, and steps all achieved rehabilitation requirements in rehabilitation group in phase II and III, there existed distinct variation between 2 phases. Rehabilitation group had a better result in cardiovascular risk factors than control group (P < .05). CONCLUSION: Community-based CR after PCI through simple but safe exercise methods can improve the AMI patient's living quality, which includes increasing cardiac ejection fraction, exercise tolerance, and physical status. It must be emphasized that the good result should be established by the foundation of close cooperation between cardiologists and general practitioners, also the importance of cooperation of patients and their families should not be ignored. The rehabilitation program we used is feasible, safe, and effective.
[Mh] Termos MeSH primário: Reabilitação Cardíaca/métodos
Serviços de Saúde Comunitária/métodos
Terapia por Exercício/métodos
Infarto do Miocárdio/reabilitação
Intervenção Coronária Percutânea/reabilitação
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Tolerância ao Exercício
Feminino
Seres Humanos
Masculino
Meia-Idade
Infarto do Miocárdio/fisiopatologia
Infarto do Miocárdio/cirurgia
Volume Sistólico
Resultado do Tratamento
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180222
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009785


  2 / 1398 MEDLINE  
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[PMID]:29369178
[Au] Autor:Chen YW; Wang CY; Lai YH; Liao YC; Wen YK; Chang ST; Huang JL; Wu TJ
[Ad] Endereço:Department of Physical Medicine and Rehabilitation.
[Ti] Título:Home-based cardiac rehabilitation improves quality of life, aerobic capacity, and readmission rates in patients with chronic heart failure.
[So] Source:Medicine (Baltimore);97(4):e9629, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Exercise tolerance and cardiac output have a major impact on the quality of life (QOL) of patients experiencing heart failure (HF). Home-based cardiac rehabilitation can significantly improve not only exercise tolerance but also peak oxygen uptake ((Equation is included in full-text article.)peak), and the QOL in patients with HF. The aim of this prospective study was to evaluate the beneficial effects of home-based cardiac rehabilitation on the quality of medical care in patients with chronic HF. METHODS: This study was a randomized prospective trial. HF patients with a left ventricular ejection fraction (LVEF) of less than 50% were included in this study. We randomly assigned patients to the control group (n = 18) and the interventional group (n = 19). Within the interventional group, we arranged individualized rehabilitation programs, including home-based cardiac rehabilitation, diet education, and management of daily activity over a 3-month period. Information such as general data, laboratory data, Cardiopulmonary Exercise Test (CPET) results, Six-minute Walk Test (6MWT) results, and the scores for the Minnesota Living with Heart Failure Questionnaire (MLHFQ) before and after the intervention, was collected from all patients in this study. RESULTS: Patients enrolled in the home-based cardiac rehabilitation programs displayed statistically significant improvement in (Equation is included in full-text article.)peak (18.2 ±â€Š4.1 vs 20.9 ±â€Š6.6 mL/kg/min, P = .02), maximal 6-Minute Walking Distance (6MWD) (421 ±â€Š90 vs 462 ±â€Š74 m, P = .03), anaerobic threshold (12.4 ±â€Š2.5 vs 13.4 ±â€Š2.6 mL/kg/min, P = .005), and QOL. In summary, patients receiving home-based cardiac rehabilitation experienced a 14.2% increase in (Equation is included in full-text article.)peak, a 37% increase in QOL score, and an improvement of 41 m on the 6MWD test. The 90-day readmission rate for patients reduced to 5% from 14% after receiving cardiac rehabilitation. CONCLUSION: Home-based cardiac rehabilitation offered the most improved results in functional capacity, QOL, and a reduced the rate of readmission within 90 days.
[Mh] Termos MeSH primário: Reabilitação Cardíaca/métodos
Insuficiência Cardíaca/reabilitação
Serviços de Assistência Domiciliar
Readmissão do Paciente/estatística & dados numéricos
Qualidade de Vida
[Mh] Termos MeSH secundário: Atividades Cotidianas
Idoso
Débito Cardíaco
Doença Crônica
Tolerância ao Exercício
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Resultado do Tratamento
Função Ventricular Esquerda
Teste de Caminhada
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009629


  3 / 1398 MEDLINE  
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[PMID]:28452558
[Au] Autor:Abreu A
[Ad] Endereço:Department of Cardiology, Santa Marta Hospital, CHLC, Lisbon, Portugal.
[Ti] Título:Cardiac rehabilitation in cardiac valve surgery patients: Beyond cost-effectiveness.
[So] Source:Eur J Prev Cardiol;24(11):1145-1147, 2017 07.
[Is] ISSN:2047-4881
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Reabilitação Cardíaca
Análise Custo-Benefício
[Mh] Termos MeSH secundário: Implante de Prótese de Valva Cardíaca/reabilitação
Valvas Cardíacas/cirurgia
Seres Humanos
Pacientes
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1177/2047487317706180


  4 / 1398 MEDLINE  
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[PMID]:27777324
[Au] Autor:Rauch B; Davos CH; Doherty P; Saure D; Metzendorf MI; Salzwedel A; Völler H; Jensen K; Schmid JP; 'Cardiac Rehabilitation Section', European Association of Preventive Cardiology (EAPC), in cooperation with the Institute of Medical Biometry and Informatics (IMBI), Department of Medical Biometry, University of Heidelberg, and the Cochrane Metabolic and Endocrine Disorders Group, Institute of General Practice, Heinrich-Heine University, Düsseldorf, Germany
[Ad] Endereço:1 Institut für Herzinfarktforschung Ludwigshafen, Germany.
[Ti] Título:The prognostic effect of cardiac rehabilitation in the era of acute revascularisation and statin therapy: A systematic review and meta-analysis of randomized and non-randomized studies - The Cardiac Rehabilitation Outcome Study (CROS).
[So] Source:Eur J Prev Cardiol;23(18):1914-1939, 2016 12.
[Is] ISSN:2047-4881
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Background The prognostic effect of multi-component cardiac rehabilitation (CR) in the modern era of statins and acute revascularisation remains controversial. Focusing on actual clinical practice, the aim was to evaluate the effect of CR on total mortality and other clinical endpoints after an acute coronary event. Design Structured review and meta-analysis. Methods Randomised controlled trials (RCTs), retrospective controlled cohort studies (rCCSs) and prospective controlled cohort studies (pCCSs) evaluating patients after acute coronary syndrome (ACS), coronary artery bypass grafting (CABG) or mixed populations with coronary artery disease (CAD) were included, provided the index event was in 1995 or later. Results Out of n = 18,534 abstracts, 25 studies were identified for final evaluation (RCT: n = 1; pCCS: n = 7; rCCS: n = 17), including n = 219,702 patients (after ACS: n = 46,338; after CABG: n = 14,583; mixed populations: n = 158,781; mean follow-up: 40 months). Heterogeneity in design, biometrical assessment of results and potential confounders was evident. CCSs evaluating ACS patients showed a significantly reduced mortality for CR participants (pCCS: hazard ratio (HR) 0.37, 95% confidence interval (CI) 0.20-0.69; rCCS: HR 0.64, 95% CI 0.49-0.84; odds ratio 0.20, 95% CI 0.08-0.48), but the single RCT fulfilling Cardiac Rehabilitation Outcome Study (CROS) inclusion criteria showed neutral results. CR participation was also associated with reduced mortality after CABG (rCCS: HR 0.62, 95% CI 0.54-0.70) and in mixed CAD populations. Conclusions CR participation after ACS and CABG is associated with reduced mortality even in the modern era of CAD treatment. However, the heterogeneity of study designs and CR programmes highlights the need for defining internationally accepted standards in CR delivery and scientific evaluation.
[Mh] Termos MeSH primário: Reabilitação Cardíaca/métodos
Inibidores de Hidroximetilglutaril-CoA Redutases/uso terapêutico
Isquemia Miocárdica
Revascularização Miocárdica/reabilitação
[Mh] Termos MeSH secundário: Seres Humanos
Isquemia Miocárdica/tratamento farmacológico
Isquemia Miocárdica/reabilitação
Isquemia Miocárdica/cirurgia
Prognóstico
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161101
[St] Status:MEDLINE
[do] DOI:10.1177/2047487316671181


  5 / 1398 MEDLINE  
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[PMID]:29232073
[Au] Autor:Centers for Medicare & Medicaid Services (CMS), HHS.
[Ti] Título:Medicare Program; Cancellation of Advancing Care Coordination Through Episode Payment and Cardiac Rehabilitation Incentive Payment Models; Changes to Comprehensive Care for Joint Replacement Payment Model: Extreme and Uncontrollable Circumstances Policy for the Comprehensive Care for Joint Replacement Payment Model. Final rule; interim final rule with comment period.
[So] Source:Fed Regist;82(230):57066-104, 2017 Dec 01.
[Is] ISSN:0097-6326
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This final rule cancels the Episode Payment Models (EPMs) and Cardiac Rehabilitation (CR) Incentive Payment Model and rescinds the regulations governing these models. It also implements certain revisions to the Comprehensive Care for Joint Replacement (CJR) model, including: Giving certain hospitals selected for participation in the CJR model a one-time option to choose whether to continue their participation in the model; technical refinements and clarifications for certain payment, reconciliation and quality provisions; and a change to increase the pool of eligible clinicians that qualify as affiliated practitioners under the Advanced Alternative Payment Model (Advanced APM) track. An interim final rule with comment period is being issued in conjunction with this final rule in order to address the need for a policy to provide some flexibility in the determination of episode costs for providers located in areas impacted by extreme and uncontrollable circumstances.
[Mh] Termos MeSH primário: Artroplastia de Substituição/economia
Reabilitação Cardíaca/economia
Reembolso de Seguro de Saúde/economia
Medicare/economia
Mecanismo de Reembolso/economia
Reembolso de Incentivo/economia
[Mh] Termos MeSH secundário: Cuidado Periódico
Seres Humanos
Reembolso de Seguro de Saúde/legislação & jurisprudência
Medicare/legislação & jurisprudência
Mecanismo de Reembolso/legislação & jurisprudência
Reembolso de Incentivo/legislação & jurisprudência
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:T
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE


  6 / 1398 MEDLINE  
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[PMID]:29203953
[Au] Autor:Yates BC; Pozehl B; Kupzyk K; Epstein CM; Deka P
[Ad] Endereço:1 College of Nursing, University of Nebraska Medical Center, Omaha, NE, USA2 College of Nursing, University of Nebraska Medical Center, Lincoln, NE, USA.
[Ti] Título:Are Heart Failure and Coronary Artery Bypass Surgery Patients Meeting Physical Activity Guidelines?
[So] Source:Rehabil Nurs;42(3):119-124, 2017 May-Jun.
[Is] ISSN:2048-7940
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: The purpose of this study was to describe subjective and objective physical activity (PA) levels of two groups of cardiovascular patients who were either post-coronary artery bypass graft (CABG) surgery or diagnosed with heart failure (HF). Design: A descriptive comparative design was used for this secondary analysis of data from two prior studies. Methods: A convenience sample of 62 outpatients was used to examine PA objectively (Actiheart accelerometer) and subjectively (PA interview). Findings: Objectively, 33% of CABG patients and no HF patients met PA recommendations of ≥ 150 min/week. Subjectively, 56% of CABG and 38% of HF patients reported meeting PA recommendations. Conclusions: Few patients in the current study met PA recommendations. Clinical Relevance: Innovative rehabilitation nursing practice strategies are needed (e.g., use of activity trackers, making PA a vital sign) to assist patients in gaining the knowledge and skills to be more active and adhere to PA recommendations.
[Mh] Termos MeSH primário: Reabilitação Cardíaca/enfermagem
Ponte de Artéria Coronária/reabilitação
Exercício
Fidelidade a Diretrizes/estatística & dados numéricos
Insuficiência Cardíaca/reabilitação
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Vida Independente
Masculino
Meia-Idade
Guias de Prática Clínica como Assunto
Enfermagem em Reabilitação
Inquéritos e Questionários
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1002/rnj.257


  7 / 1398 MEDLINE  
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[PMID]:29020079
[Au] Autor:Vogel J; Auinger A; Riedl R; Kindermann H; Helfert M; Ocenasek H
[Ad] Endereço:School of Management, University of Applied Sciences Upper Austria, Steyr, Austria.
[Ti] Título:Digitally enhanced recovery: Investigating the use of digital self-tracking for monitoring leisure time physical activity of cardiovascular disease (CVD) patients undergoing cardiac rehabilitation.
[So] Source:PLoS One;12(10):e0186261, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Research has shown that physical activity is essential in the prevention and treatment of chronic diseases like cardiovascular disease (CVD). Smart wearables (e.g., smartwatches) are increasingly used to foster and monitor human behaviour, including physical activity. However, despite this increased usage, little evidence is available on the effects of smart wearables in behaviour change. The little research which is available typically focuses on the behaviour of healthy individuals rather than patients. In this study, we investigate the effects of using smart wearables by patients undergoing cardiac rehabilitation. A field experiment involving 29 patients was designed and participants were either assigned to the study group (N = 13 patients who finished the study and used a self-tracking device) or the control group (N = 16 patients who finished the study and did not use a device). For both groups data about physiological performance during cardiac stress test was collected at the beginning (baseline), in the middle (in week 6, at the end of the rehabilitation in the organized rehabilitation setting), and at the end of the study (after 12 weeks, at the end of the rehabilitation, including the organized rehabilitation plus another 6 weeks of self-organized rehabilitation). Comparing the physiological performance of both groups, the data showed significant differences. The participants in the study group not only maintained the same performance level as during the midterm examination in week 6, they improved performance even further during the six weeks that followed. The results presented in this paper provide evidence for positive effects of digital self-tracking by patients undergoing cardiac rehabilitation on performance of the cardiovascular system. In this way, our study provides novel insight about the effects of the use of smart wearables by CVD patients. Our findings have implications for the design of self-management approaches in a patient rehabilitation setting. In essence, the use of smart wearables can prolong the success of the rehabilitation outside of the organized rehabilitation setting.
[Mh] Termos MeSH primário: Reabilitação Cardíaca/instrumentação
Doenças Cardiovasculares/fisiopatologia
Doenças Cardiovasculares/terapia
Exercício
Atividades de Lazer
Monitorização Fisiológica/instrumentação
[Mh] Termos MeSH secundário: Seres Humanos
Masculino
Meia-Idade
Estilo de Vida Sedentário
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171012
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186261


  8 / 1398 MEDLINE  
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[PMID]:28966333
[Au] Autor:Adachi H
[Ad] Endereço:Department of Cardiology, Gunma Prefectural Cardiovascular Center.
[Ti] Título:Cardiopulmonary Exercise Test.
[So] Source:Int Heart J;58(5):654-665, 2017 Oct 21.
[Is] ISSN:1349-3299
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The cardiopulmonary exercise test (CPX) is an essential examination for detecting pathophysiological derangement and determining treatment policy because it clarifies not only the changes of hemodynamics but also abnormality in the whole body during exercise where heart disease patients often feel symptoms.To utilize CPX effectively, we must understand each parameter, such as peak oxygen uptake (peak VO ), peak VO /HR, and VE/VCO . In addition, comparison of each parameter, for example, peak VO and VE/VCO , and peak VO and peak VO /HR, is useful to detect the pathophysiological abnormalities.In this article, I will describe how CPX should be used in clinical settings.
[Mh] Termos MeSH primário: Reabilitação Cardíaca/métodos
Teste de Esforço/métodos
Cardiopatias
Hemodinâmica/fisiologia
[Mh] Termos MeSH secundário: Cardiopatias/diagnóstico
Cardiopatias/fisiopatologia
Cardiopatias/reabilitação
Seres Humanos
Consumo de Oxigênio
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171003
[St] Status:MEDLINE
[do] DOI:10.1536/ihj.17-264


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[PMID]:28966316
[Au] Autor:Takagawa Y; Yagi S; Ise T; Ishii A; Nishikawa K; Fukuda D; Kusunose K; Matsuura T; Tobiume T; Yamaguchi K; Yamada H; Soeki T; Wakatsuki T; Shimabukuro M; Katoh S; Aihara KI; Akaike M; Sata M
[Ad] Endereço:Department of Cardiovascular Medicine, Tokushima University Graduate School of Biomedical Sciences.
[Ti] Título:Improved Exercise Capacity After Cardiac Rehabilitation Is Associated with Reduced Visceral Fat in Patients with Chronic Heart Failure.
[So] Source:Int Heart J;58(5):746-751, 2017 Oct 21.
[Is] ISSN:1349-3299
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Participation in a comprehensive cardiac rehabilitation (CR) program has been shown to reduce mortality and improve exercise capacity and symptoms in patients with chronic heart failure (CHF). Reduced exercise capacity leads to a concomitant reduction of skeletal muscle mass and accumulation of body fat. However, it is currently unknown whether CR reduces visceral adipose tissue (VAT) and/or subcutaneous abdominal adipose tissue (SAT) in patients with CHF. In addition, the body composition associated with improved exercise capacity after CR in patients with CHF has not been previously studied. Nineteen CHF patients who were categorized as NYHA functional class II or III and had received optimal medical treatment including a CR program for 5 months were enrolled in this study. The CR program significantly increased peak VO and reduced B-type natriuretic peptide. In addition, fat and body composition analysis showed reductions in the visceral fat tissue (VAT) area, subcutaneous abdominal adipose tissue (SAT) area, body weight, and total fat weight after CR. There were no changes in total water weight and total muscle weight. Single regression analysis revealed that the amelioration of reduced exercise capacity seen after CR is associated with reduced VAT area but not with SAT area or body weight. In conclusion, CR reduces VAT and improves exercise capacity in patients with CHF. This suggests that reducing VAT is important for CR to be most effective in the treatment of CHF.
[Mh] Termos MeSH primário: Reabilitação Cardíaca/métodos
Tolerância ao Exercício/fisiologia
Insuficiência Cardíaca/reabilitação
Gordura Intra-Abdominal
Obesidade/fisiopatologia
Perda de Peso/fisiologia
[Mh] Termos MeSH secundário: Composição Corporal
Feminino
Seguimentos
Insuficiência Cardíaca/complicações
Insuficiência Cardíaca/fisiopatologia
Seres Humanos
Masculino
Meia-Idade
Obesidade/complicações
Obesidade/reabilitação
Consumo de Oxigênio
Prognóstico
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171003
[St] Status:MEDLINE
[do] DOI:10.1536/ihj.16-454


  10 / 1398 MEDLINE  
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[PMID]:28875970
[Au] Autor:Kapusta J; Mejer-Barczewska A; Kowalczyk E; Irzmanski R; Kowalski J
[Ad] Endereço:Medical University of Lodz: Department of Internal Medicine and Cardiac Rehabilitation.
[Ti] Título:[Evaluation of selected vascular active factors in patients after myocardial infarction subjected to cardiac rehabilitation].
[Ti] Título:Ocena stezenia wybranych czynników naczyniowo aktywnych u chorych po ostrym zespole wiencowym poddanych rehabilitacji kardiologicznej..
[So] Source:Pol Merkur Lekarski;43(254):56-60, 2017 Aug 21.
[Is] ISSN:1426-9686
[Cp] País de publicação:Poland
[La] Idioma:pol
[Ab] Resumo:Atherosclerosis is an inflammatory process that develops in the coronary arteries. Clinically active agents such as proinflammatory interleukins, TNF-α, tissue inhibitors of metalloproteinases (including TIMP-1), and vascular endothelial growth factor (VEGF), are important factors in the development of acute coronary syndromes. AIM: The aim of the study was to evaluate the effect of cardiac rehabilitation (stage II) on the concentration of selected vascular active factors (IL- 1, IL-6, TIMP-1, VEGF). MATERIALS AND METHODS: The study involved 24 patients after ACS who underwent complex cardiac rehabilitation (stage II) in the Department of Internal Medicine and Cardiac Rehabilitation at the Medical University of Lodz. The study involved 20 men and 4 women aged 42-78 years (average age 58.75 ± 8.45 years). The ELISA method was used in the vascular endothelial cell assay using readymade sets for determining individual molecules: Human Quantum ELISA Kit (DTM100; R & D Systems, BIOKOM, Poland), Human VEGF Quantikine ELISA Kit (DVE00; R & D Systems, BIOKOM, Poland) Human IL-1 beta / IL-1F2 Quantikine ELISA Kit (DLB50; R & D Systems, BIOKOM, Poland), Human IL-6 Quantikine ELISA Kit (D6050, R & D Systems, BIOKOM, Poland). TIMP-1 concentration is expressed in ng / ml, VEGF in pg / ml, IL-1 in pg / ml, IL-6 pg / ml. The results of the study were analyzed statistically at significance level p <0,05. RESULTS: There was no significant effect of cardiac rehabilitation on vascular endothelial factors: TIMP-1, VEGF, IL-6. Significant effect of cardiac rehabilitation was observed on the increase of IL-1 concentration (p=0.016). CONCLUSIONS: The absence of post-cardiac rehabilitation in patients after ACS, significant changes in vascular endothelial activity, confirm the hypothesis that adequate physical effort does not involve changes in blood concentrations and justifies perception of rehabilitation as a safe and risk-free intervention.
[Mh] Termos MeSH primário: Reabilitação Cardíaca
Infarto do Miocárdio/reabilitação
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Interleucina-1/sangue
Interleucina-6/sangue
Masculino
Meia-Idade
Infarto do Miocárdio/sangue
Inibidor Tecidual de Metaloproteinase-1/sangue
Fator A de Crescimento do Endotélio Vascular/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (IL6 protein, human); 0 (Interleukin-1); 0 (Interleukin-6); 0 (TIMP1 protein, human); 0 (Tissue Inhibitor of Metalloproteinase-1); 0 (VEGFA protein, human); 0 (Vascular Endothelial Growth Factor A)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE



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