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[PMID]:28459281
[Au] Autor:Hides JA; Walsh JC; Smith MMF; Mendis MD
[Ad] Endereço:Centre for Musculoskeletal Research, Mary MacKillop Institute for Health Research, Australian Catholic University, Brisbane, Australia.
[Ti] Título:Self-Managed Exercises, Fitness and Strength Training, and Multifidus Muscle Size in Elite Footballers.
[So] Source:J Athl Train;52(7):649-655, 2017 Jul.
[Is] ISSN:1938-162X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Low back pain (LBP) and lower limb injuries are common among Australian Football League (AFL) players. Smaller size of 1 key trunk muscle, the lumbar multifidus (MF), has been associated with LBP and injuries in footballers. The size of the MF muscle has been shown to be modifiable with supervised motor-control training programs. Among AFL players, supervised motor-control training has also been shown to reduce the incidence of lower limb injuries and was associated with increased player availability for games. However, the effectiveness of a self-managed MF exercise program is unknown. OBJECTIVE: To investigate the effect of self-managed exercises and fitness and strength training on MF muscle size in AFL players with or without current LBP. DESIGN: Cross-sectional study. SETTING: Professional AFL context. PATIENTS OR OTHER PARTICIPANTS: Complete data were available for 242 players from 6 elite AFL clubs. INTERVENTION(S): Information related to the presence of LBP and history of injury was collected at the start of the preseason. At the end of the preseason, data were collected regarding performance of MF exercises as well as fitness and strength training. Ultrasound imaging of the MF muscle was conducted at the start and end of the preseason. MAIN OUTCOME MEASURE(S): Size of the MF muscles. RESULTS: An interaction effect was found between performance of MF exercises and time (F = 13.89, P ≤ .001). Retention of MF muscle size was greatest in players who practiced the MF exercises during the preseason (F = 4.77, P = .03). Increased adherence to fitness and strength training was associated with retained MF muscle size over the preseason (F = 5.35, P = .02). CONCLUSIONS: Increased adherence to a self-administered MF exercise program and to fitness and strength training was effective in maintaining the size of the MF muscle in the preseason.
[Mh] Termos MeSH primário: Traumatismos em Atletas/prevenção & controle
Terapia por Exercício/métodos
Futebol Americano/fisiologia
Região Lombossacral/fisiologia
Músculos Paraespinais/fisiologia
Treinamento de Resistência/métodos
[Mh] Termos MeSH secundário: Adulto
Austrália
Estudos Transversais
Feminino
Futebol Americano/lesões
Seres Humanos
Dor Lombar/prevenção & controle
Masculino
Ultrassonografia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.4085/1062-6050-52.3.13


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[PMID]:28453780
[Au] Autor:Billings LK; Jablonski KA; Warner AS; Cheng YC; McAteer JB; Tipton L; Shuldiner AR; Ehrmann DA; Manning AK; Dabelea D; Franks PW; Kahn SE; Pollin TI; Knowler WC; Altshuler D; Florez JC; Diabetes Prevention Program Research Group
[Ad] Endereço:Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114.
[Ti] Título:Variation in Maturity-Onset Diabetes of the Young Genes Influence Response to Interventions for Diabetes Prevention.
[So] Source:J Clin Endocrinol Metab;102(8):2678-2689, 2017 Aug 01.
[Is] ISSN:1945-7197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Context: Variation in genes that cause maturity-onset diabetes of the young (MODY) has been associated with diabetes incidence and glycemic traits. Objectives: This study aimed to determine whether genetic variation in MODY genes leads to differential responses to insulin-sensitizing interventions. Design and Setting: This was a secondary analysis of a multicenter, randomized clinical trial, the Diabetes Prevention Program (DPP), involving 27 US academic institutions. We genotyped 22 missense and 221 common variants in the MODY-causing genes in the participants in the DPP. Participants and Interventions: The study included 2806 genotyped DPP participants randomized to receive intensive lifestyle intervention (n = 935), metformin (n = 927), or placebo (n = 944). Main Outcome Measures: Association of MODY genetic variants with diabetes incidence at a median of 3 years and measures of 1-year ß-cell function, insulinogenic index, and oral disposition index. Analyses were stratified by treatment group for significant single-nucleotide polymorphism × treatment interaction (Pint < 0.05). Sequence kernel association tests examined the association between an aggregate of rare missense variants and insulinogenic traits. Results: After 1 year, the minor allele of rs3212185 (HNF4A) was associated with improved ß-cell function in the metformin and lifestyle groups but not the placebo group; the minor allele of rs6719578 (NEUROD1) was associated with an increase in insulin secretion in the metformin group but not in the placebo and lifestyle groups. Conclusions: These results provide evidence that genetic variation among MODY genes may influence response to insulin-sensitizing interventions.
[Mh] Termos MeSH primário: Fatores de Transcrição Hélice-Alça-Hélice Básicos/genética
Diabetes Mellitus Tipo 2/genética
Terapia por Exercício
Fator 4 Nuclear de Hepatócito/genética
Programas de Redução de Peso
[Mh] Termos MeSH secundário: Diabetes Mellitus Tipo 2/prevenção & controle
Variação Genética
Glucoquinase/genética
Fator 1-alfa Nuclear de Hepatócito/genética
Fator 1-beta Nuclear de Hepatócito/genética
Proteínas de Homeodomínio/genética
Seres Humanos
Metformina/uso terapêutico
Mutação de Sentido Incorreto
Polimorfismo de Nucleotídeo Único
Comportamento de Redução do Risco
Transativadores/genética
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Basic Helix-Loop-Helix Transcription Factors); 0 (HNF1A protein, human); 0 (HNF1B protein, human); 0 (HNF4A protein, human); 0 (Hepatocyte Nuclear Factor 1-alpha); 0 (Hepatocyte Nuclear Factor 4); 0 (Homeodomain Proteins); 0 (NEUROD1 protein, human); 0 (Trans-Activators); 0 (pancreatic and duodenal homeobox 1 protein); 138674-15-4 (Hepatocyte Nuclear Factor 1-beta); 9100L32L2N (Metformin); EC 2.7.1.2 (Glucokinase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1210/jc.2016-3429


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[PMID]:29179818
[Au] Autor:Gür F; Can Gür G; Okanli A
[Ad] Endereço:University of Karadeniz Technical, Faculty of Sport Science, Trabzon 61000, Turkey. Electronic address: fatihgur@ktu.edu.tr.
[Ti] Título:The Effect of the Cognitive-behavioral Model-based Psychoeducation and Exercise Intervention on Quality of Life in Alcohol Use Disorder.
[So] Source:Arch Psychiatr Nurs;31(6):541-548, 2017 12.
[Is] ISSN:1532-8228
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The aim of the study was to assess the effect of the cognitive behavior model (CBM)-based psychoeducation and exercise intervention on quality of life (QoL) in alcohol use disorder (AUD). DESIGN: This study was a non-randomized controlled trial. METHODS: CBM-based psychoeducation and exercise intervention was applied to the experimental group four times a week for 6weeks; no intervention was applied to the control group. FINDINGS: No difference was seen between the points of pretest QoL of the experimental and control groups (p>0.05). However, according to the posttest, the experimental group's mean score of QoL was higher than the control groups (p<0.05). CONCLUSION: It was found that CBM-based psychoeducation and exercise intervention applied to individuals with AUD affected the QoL positively. CLINICAL RELEVANCE: CBM-based psychoeducation and exercise intervention can be used by nurses to improve AUD individuals' quality of life.
[Mh] Termos MeSH primário: Transtornos Relacionados ao Uso de Álcool/psicologia
Terapia Cognitiva
Terapia por Exercício
Qualidade de Vida/psicologia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Masculino
Meia-Idade
Educação de Pacientes como Assunto/métodos
Enfermagem Psiquiátrica
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM; N
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE


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[PMID]:29465559
[Au] Autor:Zhang Y; Cao H; Jiang P; Tang H
[Ad] Endereço:Department of Geriatrics Cardiology.
[Ti] Título:Cardiac rehabilitation in acute myocardial infarction patients after percutaneous coronary intervention: A community-based study.
[So] Source:Medicine (Baltimore);97(8):e9785, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Acute myocardial infarction (AMI) is one of the leading causes of death and physical disability worldwide. However, the development of community- based cardiac rehabilitation (CR) in AMI patients is hysteretic. Here, we aimed to evaluate the safety and efficacy of CR applied in the community in AMI patients who underwent percutaneous coronary intervention (PCI). METHODS: A total of 130 ST-segment elevated myocardial infarction (STEMI) patients after PCI were randomly divided into 2 groups in the community, rehabilitation group (n = 65) and control group (n = 65). Cardiac function, a 6-minute walk distance, exercise time and steps, cardiovascular risk factors were monitored respectively and compared before and after the intervention of 2 groups. The software of EpiData 3.1 was used to input research data and SPSS16.0 was used for statistical analysis. RESULTS: After a planned rehabilitation intervention, the rehabilitation group showed better results than the control group. The rehabilitation group had a significant improvement in recurrence angina and readmission (P < .01). Left ventricular ejection fraction (LVEF) of rehabilitation group showed improvement in phase II (t = 4.963, P < .01) and phase III (t = 11.802, P < .01), and the New York Heart Association (NYHA) classification was recovered within class II. There was a significant difference compared with before (Z = 7.238, P < .01). Six minutes walking distance, aerobic exercise time, and steps all achieved rehabilitation requirements in rehabilitation group in phase II and III, there existed distinct variation between 2 phases. Rehabilitation group had a better result in cardiovascular risk factors than control group (P < .05). CONCLUSION: Community-based CR after PCI through simple but safe exercise methods can improve the AMI patient's living quality, which includes increasing cardiac ejection fraction, exercise tolerance, and physical status. It must be emphasized that the good result should be established by the foundation of close cooperation between cardiologists and general practitioners, also the importance of cooperation of patients and their families should not be ignored. The rehabilitation program we used is feasible, safe, and effective.
[Mh] Termos MeSH primário: Reabilitação Cardíaca/métodos
Serviços de Saúde Comunitária/métodos
Terapia por Exercício/métodos
Infarto do Miocárdio/reabilitação
Intervenção Coronária Percutânea/reabilitação
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Tolerância ao Exercício
Feminino
Seres Humanos
Masculino
Meia-Idade
Infarto do Miocárdio/fisiopatologia
Infarto do Miocárdio/cirurgia
Volume Sistólico
Resultado do Tratamento
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180222
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009785


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[PMID]:29368480
[Au] Autor:Mohammed Y; Qazi ZN; Shuler FD; Garabekyan T
[Ti] Título:Hip Pain in the Pre-Arthritic Patient: A Guide for the Primary Care Physician.
[So] Source:W V Med J;112(5):48-53, 2016 Sep-Oct.
[Is] ISSN:0043-3284
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Adolescents and young adults (less than 30 years of age) with pre-arthritic hip pain constitute a diagnostic dilemma for the primary care physician. The most common underlying diagnoses range from benign muscle strains/joint sprains to stress reactions, insufficiency fractures, and tears involving the articular cartilage/labrum in the setting of femoroacetabular impingement, a hip shape abnormality that is present in up to 90% of this age group. Undetected or left untreated these seemingly innocuous disorders can result in significant loss of function and, in some cases, irreversible joint damage. Despite sharing common predisposing factors, many of the above diagnoses can be identified with a focused history and physical examination. Conservative management may be safely initiated without advanced imaging, reserving orthopaedic consultation for refractory cases or more serious diagnoses. The presented focused hip clinical examination has 98% sensitivity in localizing intra-articular hip pathology and will be helpful to direct appropriate referrals. This article will serve as a guide for primary care physicians undertaking the difficult task of evaluating and treating a young patient with hip pain.
[Mh] Termos MeSH primário: Artralgia/terapia
Terapia por Exercício
Articulação do Quadril/patologia
Exame Físico
Médicos de Atenção Primária
Encaminhamento e Consulta
[Mh] Termos MeSH secundário: Adolescente
Artralgia/diagnóstico por imagem
Artralgia/etiologia
Terapia por Exercício/métodos
Impacto Femoroacetabular/complicações
Guias como Assunto
Seres Humanos
Medição da Dor
Satisfação do Paciente
Exame Físico/métodos
Modalidades de Fisioterapia
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE


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[PMID]:28458486
[Au] Autor:Adepoju F; Hamzat T; Akinyinka O
[Ad] Endereço:Department of Physiotherapy, University College Hospital, Ibadan, Nigeria.
[Ti] Título:Comparative Efficacy of Progressive Resistance Exercise and Biomechanical Ankle Platform System on Functional Indices of Children with Cerebral Palsy.
[So] Source:Ethiop J Health Sci;27(1):11-16, 2017 Jan.
[Is] ISSN:2413-7170
[Cp] País de publicação:Ethiopia
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Progressive Resistance Exercise (PRE) and Biomechanical Ankle Platform System (BAPS) are two of the protocols available in managing children with Cerebral Palsy (CP). The comparative effects of these modalities on selected functional indices of ambulatory type CP were the focus of this study. METHODS: Twenty-eight children with hemiplegic or diplegic CP receiving care at a tertiary health facility in Ibadan were consecutively recruited. They were systematically assigned into two intervention groups. Namely PRE, BAPS. Both groups received intervention twice weekly for 16 weeks. At baseline, 8 and 16 weeks of intervention balance and functional mobility were assessed using Berg Balance Scale (BBS) and modified timed-up-and-go test (TUG) respectively. Chi-square, Fisher's Exact tests, One way and repeated measures ANOVA were carried out. Level of significance (p) was set at 0.05. RESULTS: There were significant differences in the functional indices of participants in the BAPS group at the end of the intervention (p < 0.05). The two groups (BAPS and PRE) were not significantly different at baseline and 8 and 16 weeks (p > 0.05). All outcome measures increased in both groups from baseline to the end of the intervention period. CONCLUSION: The two intervention protocols demonstrated improvements in the areas assessed. Comparatively, both PRE and BAPS could be used to promote function in CP.
[Mh] Termos MeSH primário: Paralisia Cerebral/terapia
Terapia por Exercício/instrumentação
Terapia por Exercício/métodos
Treinamento de Resistência/instrumentação
Treinamento de Resistência/métodos
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Feminino
Seres Humanos
Masculino
Nigéria
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:29377893
[Au] Autor:Dor-Haim H; Barak S; Horowitz M; Yaakobi E; Katzburg S; Swissa M; Lotan C
[Ad] Endereço:Hadassah Hebrew University Hospital Heart Institute, Jerusalem, Israel.
[Ti] Título:Improvement in cardiac dysfunction with a novel circuit training method combining simultaneous aerobic-resistance exercises. A randomized trial.
[So] Source:PLoS One;13(1):e0188551, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Exercise is considered a valuable nonpharmacological intervention modality in cardiac rehabilitation (CR) programs in patients with ischemic heart disease. The effect of aerobic interval exercise combined with alternating sets of resistance training (super-circuit training, SCT) on cardiac patients' with reduced left ventricular function, post-myocardial infarction (MI) has not been thoroughly investigated. AIM OF STUDY: to improve cardiac function with a novel method of combined aerobic-resistance circuit training in a randomized control trial by way of comparing the effectiveness of continuous aerobic training (CAT) to SCT on mechanical cardiac function. Secondary to compare their effect on aerobic fitness, manual strength, and quality of life in men post MI. Finally, to evaluate the safety and feasibility of SCT. METHODS: 29 men post-MI participants were randomly assigned to either 12-weeks of CAT (n = 15) or SCT (n = 14). Both groups, CAT and SCT exercised at 60%-70% and 75-85% of their heart rate reserve, respectively. The SCT group also engaged in intermittently combined resistance training. Primary outcome measure was echocardiography. Secondary outcome measures were aerobic fitness, strength, and quality of life (QoL). The effectiveness of the two training programs was examined via paired t-tests and Cohen's d effect size (ES). RESULTS: Post-training, only the SCT group presented significant changes in echocardiography (a reduction in E/e' and an increase in ejection fraction, P<0.05). Similarly, only the SCT group presented significant changes in aerobic fitness (an increase in maximal metabolic equivalent, P<0.05). In addition, SCT improvement in the physical component of QoL was greater than this observed in the CAT group. In both training programs, no adverse events were observed. CONCLUSION: Men post-MI stand to benefit from both CAT and SCT. However, in comparison to CAT, as assessed by echocardiography, SCT may yield greater benefits to the left ventricle mechanical function as well as to the patient's aerobic fitness and physical QoL. Moreover, the SCT program was found to be feasible as well as safe.
[Mh] Termos MeSH primário: Exercícios em Circuitos/métodos
Terapia por Exercício/métodos
Infarto do Miocárdio/reabilitação
[Mh] Termos MeSH secundário: Idoso
Exercício/fisiologia
Testes de Função Cardíaca/métodos
Seres Humanos
Masculino
Meia-Idade
Consumo de Oxigênio
Qualidade de Vida
Treinamento de Resistência/métodos
Função Ventricular Esquerda/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180130
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188551


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[PMID]:29366748
[Au] Autor:Teixeira RB; Zimmer A; de Castro AL; Carraro CC; Casali KR; Dias IGM; Godoy AEG; Litvin IE; Belló-Klein A; da Rosa Araujo AS
[Ad] Endereço:Laboratório de Fisiologia Cardiovascular, Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
[Ti] Título:Exercise training versus T3 and T4 hormones treatment: The differential benefits of thyroid hormones on the parasympathetic drive of infarcted rats.
[So] Source:Life Sci;196:93-101, 2018 Mar 01.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:AIMS: This study aimed to investigate whether beneficial effects of thyroid hormones are comparable to those provided by the aerobic exercise training, to verify its applicability as a therapeutic alternative to reverse the pathological cardiac remodeling post-infarction. MATERIALS AND METHODS: Male rats were divided into SHAM-operated (SHAM), myocardial infarction (MI), MI subjected to exercise training (MIE), and MI who received T3 and T4 treatment (MIH) (n = 8/group). MI, MIE and MIH groups underwent an infarction surgery while SHAM was SHAM-operated. One-week post-surgery, MIE and MIH groups started the exercise training protocol (moderate intensity on treadmill), or the T3 (1.2 µg/100 g/day) and T4 (4.8 µg/100 g/day) hormones treatment by gavage, respectively, meanwhile SHAM and MI had no intervention for 9 weeks. The groups were accompanied until 74 days after surgery, when all animals were anesthetized, left ventricle echocardiography and femoral catheterization were performed, followed by euthanasia and left ventricle collection for morphological, oxidative stress, and intracellular kinases expression analysis. KEY FINDINGS: Thyroid hormones treatment was more effective in cardiac dilation and infarction area reduction, while exercise training provided more protection against fibrosis. Thyroid hormones treatment increased the lipoperoxidation and decreased GSHPx activity as compared to MI group, increased the t-Akt2 expression as compared to SHAM group, and increased the vascular parasympathetic drive. SIGNIFICANCE: Thyroid hormones treatment provided differential benefits on the LV function and autonomic modulation as compared to the exercise training. Nevertheless, the redox unbalance induced by thyroid hormones highlights the importance of more studies targeting the ideal duration of this treatment.
[Mh] Termos MeSH primário: Terapia por Exercício
Infarto do Miocárdio/tratamento farmacológico
Infarto do Miocárdio/terapia
Sistema Nervoso Parassimpático/efeitos dos fármacos
Condicionamento Físico Animal
Tiroxina/uso terapêutico
Tri-Iodotironina/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Ecocardiografia
Fibrose
Hipertrofia Ventricular Esquerda/diagnóstico por imagem
Hipertrofia Ventricular Esquerda/etiologia
Hipertrofia Ventricular Esquerda/patologia
Masculino
Infarto do Miocárdio/diagnóstico por imagem
Estresse Oxidativo/efeitos dos fármacos
Sistema Nervoso Parassimpático/fisiopatologia
Proteínas Proto-Oncogênicas c-akt/biossíntese
Proteínas Proto-Oncogênicas c-akt/genética
Ratos
Ratos Wistar
Sistema Nervoso Simpático/efeitos dos fármacos
Sistema Nervoso Simpático/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
06LU7C9H1V (Triiodothyronine); EC 2.7.11.1 (Akt2 protein, rat); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); Q51BO43MG4 (Thyroxine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE


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[PMID]:29305709
[Au] Autor:Schmidt T; Jonat W; Wesch D; Oberg HH; Adam-Klages S; Keller L; Röcken C; Mundhenke C
[Ad] Endereço:Comprehensive Cancer Center North, University of Kiel, Arnold-Heller Straße 3, Haus 14, 24105, Kiel, Germany. Thorsten.schmidt@uksh.de.
[Ti] Título:Influence of physical activity on the immune system in breast cancer patients during chemotherapy.
[So] Source:J Cancer Res Clin Oncol;144(3):579-586, 2018 Mar.
[Is] ISSN:1432-1335
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Physical activity can impact the immune system in different ways, e.g. by alteration of the humoral and cellular immune response. Physical activity at medium intensity enhances numbers of cytotoxic T cells, NK cells and macrophages in healthy people. The aim of this study was to compare the effects of endurance and resistance training on the immune system in breast cancer patients during adjuvant chemotherapy. METHODS: In a prospective, controlled and randomized intervention exploratory trial, 12-week supervised endurance or resistance training were compared with usual care twice a week. Endpoints were the absolute numbers of the immune cells such as CD3 T lymphocytes including CD4 - and CD8 , αß T cells, γδT cells, CD3 /CD16 /56 NK cells and CD19 B cells, before and after 12 weeks of treatment. Cell numbers were analyzed using fluorescence-activated cell sorting. RESULTS: Despite different physical interventions in all groups immune cell count decreased in CD3 T cells including TCR αß and CD4 T cells, NK cells and CD19 B cells 12 weeks after initiation of chemotherapy and start of the physical intervention program, while the reduction of γδ T cells and CD8 T cells is less prominent in the RT and UC group. CONCLUSION: Chemotherapy led to a decrease in nearly all measured immune cells. In this study, physical intervention with endurance or resistance training did not suppress cellular immunity any further. Larger multicenter trials are needed to evaluate the exact impact of sports intervention on immune cell subpopulations.
[Mh] Termos MeSH primário: Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Neoplasias da Mama/terapia
Terapia por Exercício/métodos
Exercício/fisiologia
Imunidade Celular/fisiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Linfócitos B/patologia
Neoplasias da Mama/tratamento farmacológico
Neoplasias da Mama/imunologia
Quimioterapia Adjuvante
Terapia Combinada
Feminino
Seres Humanos
Células Matadoras Naturais/patologia
Contagem de Linfócitos
Meia-Idade
Resistência Física
Treinamento de Resistência
Linfócitos T Citotóxicos/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180107
[St] Status:MEDLINE
[do] DOI:10.1007/s00432-017-2573-5


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[PMID]:28143359
[Au] Autor:Patterson SD; Brandner CR
[Ad] Endereço:a School of Sport, Health & Applied Science , St Marys University , London , UK.
[Ti] Título:The role of blood flow restriction training for applied practitioners: A questionnaire-based survey.
[So] Source:J Sports Sci;36(2):123-130, 2018 Jan.
[Is] ISSN:1466-447X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The purpose of the study was to investigate the current use of blood flow restriction (BFR) by practitioners during exercise/training. A questionnaire was developed and data were obtained from 250 participants, with 115 stating that they had prescribed BFR as an intervention. The most common exercise intervention used in combination with BFR was resistance exercise (99/115), followed by during passive (30/115) conditions, and during aerobic exercise (22/115). The main outcome measure for using the technique was to increase muscle mass (32.6%) followed by rehabilitation from injury (24.2%). Over half of respondents (57.4%) reported that they did not use the same cuff widths for the lower body and upper body, with varying final restriction pressures also being utilised during each different exercise modality. Most practitioners performed the technique for ~10 min each training session, 1-4 times per week. Eighty percent of practitioners rated the use of BFR as very good-excellent. The incidence rate of side effects was largest for delayed onset muscle soreness (39.2%), numbness (18.5%), fainting/dizziness (14.6%) and bruising (13.1%). These results indicate that the use of BFR training is widespread amongst practitioners; however, care should be taken to ensure that practice matches current research to ensure the safety of this technique.
[Mh] Termos MeSH primário: Músculo Esquelético/irrigação sanguínea
Fluxo Sanguíneo Regional/fisiologia
Treinamento de Resistência/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Traumatismos em Atletas/reabilitação
Estudos Transversais
Exercício/fisiologia
Terapia por Exercício/efeitos adversos
Terapia por Exercício/métodos
Feminino
Seres Humanos
Masculino
Meia-Idade
Força Muscular/fisiologia
Músculo Esquelético/anatomia & histologia
Treinamento de Resistência/efeitos adversos
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170202
[St] Status:MEDLINE
[do] DOI:10.1080/02640414.2017.1284341



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