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[PMID]:28653120
[Au] Autor:Speer S; Klein A; Kober L; Weiss A; Yohannes I; Bert C
[Ad] Endereço:Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsstraße 27, 91054, Erlangen, Germany. stefan.speer@uk-erlangen.de.
[Ti] Título:Automation of radiation treatment planning : Evaluation of head and neck cancer patient plans created by the Pinnacle scripting and Auto-Planning functions.
[Ti] Título:Automatisierte Bestrahlungsplanung : Auswertung von mit Pinnacle via Scripting und Auto-Planning erzeugten Bestrahlungsplänen von Patienten mit Kopf-Hals-Tumor..
[So] Source:Strahlenther Onkol;193(8):656-665, 2017 Aug.
[Is] ISSN:1439-099X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Intensity-modulated radiotherapy (IMRT) techniques are now standard practice. IMRT or volumetric-modulated arc therapy (VMAT) allow treatment of the tumor while simultaneously sparing organs at risk. Nevertheless, treatment plan quality still depends on the physicist's individual skills, experiences, and personal preferences. It would therefore be advantageous to automate the planning process. This possibility is offered by the Pinnacle treatment planning system (Philips Healthcare, Hamburg, Germany) via its scripting language or Auto-Planning (AP) module. MATERIALS AND METHODS: AP module results were compared to in-house scripts and manually optimized treatment plans for standard head and neck cancer plans. Multiple treatment parameters were scored to judge plan quality (100 points = optimum plan). Patients were initially planned manually by different physicists and re-planned using scripts or AP. RESULTS AND DISCUSSION: Script-based head and neck plans achieved a mean of 67.0 points and were, on average, superior to manually created (59.1 points) and AP plans (62.3 points). Moreover, they are characterized by reproducibility and lower standard deviation of treatment parameters. Even less experienced staff are able to create at least a good starting point for further optimization in a short time. However, for particular plans, experienced planners perform even better than scripts or AP. Experienced-user input is needed when setting up scripts or AP templates for the first time. Moreover, some minor drawbacks exist, such as the increase of monitor units (+35.5% for scripted plans). CONCLUSION: On average, automatically created plans are superior to manually created treatment plans. For particular plans, experienced physicists were able to perform better than scripts or AP; thus, the benefit is greatest when time is short or staff inexperienced.
[Mh] Termos MeSH primário: Algoritmos
Neoplasias de Cabeça e Pescoço/radioterapia
Linguagens de Programação
Planejamento da Radioterapia Assistida por Computador
Radioterapia Assistida por Computador
Software
[Mh] Termos MeSH secundário: Seres Humanos
Dosagem Radioterapêutica
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Resultado do Tratamento
Carga Tumoral/efeitos da radiação
[Pt] Tipo de publicação:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE
[do] DOI:10.1007/s00066-017-1150-9


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[PMID]:28410677
[Au] Autor:Hussein M; Clark CH; Nisbet A
[Ad] Endereço:Department of Medical Physics, Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK; Centre for Nuclear and Radiation Physics, University of Surrey, Guildford, UK. Electronic address: mo1310@gmail.com.
[Ti] Título:Challenges in calculation of the gamma index in radiotherapy - Towards good practice.
[So] Source:Phys Med;36:1-11, 2017 Apr.
[Is] ISSN:1724-191X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:The gamma index (γ) is one of the most commonly used metrics for the verification of complex modulated radiotherapy. The mathematical definition of the γ is computationally expensive and various techniques have been reported to speed up the calculation either by mathematically refining the γ or employing various computational techniques. These techniques can cause variation in output with different software implementations. The γ has traditionally been used to compare a 2D measured plane against a 2D or 3D dose distribution. Recently, software algorithm and hardware improvements have led to the possibility of using measured 2D data from commercial detector arrays to reconstruct a 3D-dose distribution and perform a volumetric comparison against the treatment planning system (TPS). A limitation in this approach is that commercial detector arrays have so far been limited by their spatial resolution which may affect the accuracy of the reconstructed 3D volume and subsequently the γ calculation. Additionally, 3D versus 3D γ comparison adds a layer of complication in the calculation of the γ given the increase in the number of calculation points and the result cannot be as easily interpreted in the same way as 2D comparison. This review summarises and highlights the computational challenges of the γ calculation and sheds light on some of these issues by means of a bespoke MATLAB software to demonstrate the impact of interpolation, γ search distance, resolution and 2D and 3D calculations. Finally, a recommendation is made on the minimum information that should be reported when publishing γ results.
[Mh] Termos MeSH primário: Raios gama
Radioterapia Assistida por Computador/métodos
[Mh] Termos MeSH secundário: Seres Humanos
Software
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170427
[Lr] Data última revisão:
170427
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170416
[St] Status:MEDLINE


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[PMID]:28324876
[Au] Autor:Ceylan C; Hamaci A; Ayata H; Berberoglu K; Kiliç A; Güden M; Engin K
[Ti] Título:Re-Irradiation of Locoregional NSCLC Recurrence Using Robotic Stereotactic Body Radiotherapy.
[So] Source:Oncol Res Treat;40(4):207-214, 2017.
[Is] ISSN:2296-5262
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We evaluated the efficacy, toxicity, and dose responses of re-irradiation with stereotactic body radiotherapy (SBRT) in patients with recurrent non- small cell lung cancer (NSCLC) after previous irradiation. PATIENTS AND METHODS: 28 patients were included. Previous median radiation doses were 54 and 66 Gy. The median interval time between previous radiotherapy and SBRT was 14 months. The median follow-up time after SBRT was 9 months (range 3-93 months). To evaluate the effectiveness of SBRT, local control, overall survival, and treatment-related toxicity were reported. RESULTS: SBRT doses and fractionation ranged from 60 to 30 Gy and from 3 to 8, respectively, according to previous doses, location of the recurrence, and interval time. 65% of tumor recurrences overlapped with previous treatment, while 35% of tumors recurred outside of the previous treatment. 4 patients had local progression after SBRT at their first follow-up. The Kaplan-Meier estimates of the 1- and 2-year actuarial overall survival were 71 and 42%, respectively. The mean survival following SBRT was 32.8 months, and the median survival was 21 months. No grade 3 or higher toxicities were observed. CONCLUSION: Robotic SBRT is a tolerable treatment option with manageable toxicity which can be used with radical or palliative intent in carefully selected patients with locally recurrent tumors after previous irradiation.
[Mh] Termos MeSH primário: Carcinoma Pulmonar de Células não Pequenas/mortalidade
Carcinoma Pulmonar de Células não Pequenas/radioterapia
Neoplasias Pulmonares/mortalidade
Neoplasias Pulmonares/radioterapia
Recidiva Local de Neoplasia/mortalidade
Recidiva Local de Neoplasia/radioterapia
Radiocirurgia/mortalidade
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Relação Dose-Resposta à Radiação
Feminino
Seres Humanos
Masculino
Meia-Idade
Prevalência
Lesões por Radiação
Radiocirurgia/estatística & dados numéricos
Dosagem Radioterapêutica
Radioterapia Assistida por Computador/mortalidade
Radioterapia Assistida por Computador/estatística & dados numéricos
Reirradiação/mortalidade
Reirradiação/estatística & dados numéricos
Estudos Retrospectivos
Fatores de Risco
Robótica/estatística & dados numéricos
Taxa de Sobrevida
Resultado do Tratamento
Turquia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1159/000457129


  4 / 2255 MEDLINE  
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[PMID]:28323642
[Au] Autor:Shieh CC; Caillet V; Dunbar M; Keall PJ; Booth JT; Hardcastle N; Haddad C; Eade T; Feain I
[Ad] Endereço:Sydney Medical School, The University of Sydney, NSW 2006, Australia.
[Ti] Título:A Bayesian approach for three-dimensional markerless tumor tracking using kV imaging during lung radiotherapy.
[So] Source:Phys Med Biol;62(8):3065-3080, 2017 Apr 21.
[Is] ISSN:1361-6560
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The ability to monitor tumor motion without implanted markers can potentially enable broad access to more accurate and precise lung radiotherapy. A major challenge is that kilovoltage (kV) imaging based methods are rarely able to continuously track the tumor due to the inferior tumor visibility on 2D kV images. Another challenge is the estimation of 3D tumor position based on only 2D imaging information. The aim of this work is to address both challenges by proposing a Bayesian approach for markerless tumor tracking for the first time. The proposed approach adopts the framework of the extended Kalman filter, which combines a prediction and measurement steps to make the optimal tumor position update. For each imaging frame, the tumor position is first predicted by a respiratory-correlated model. The 2D tumor position on the kV image is then measured by template matching. Finally, the prediction and 2D measurement are combined based on the 3D distribution of tumor positions in the past 10 s and the estimated uncertainty of template matching. To investigate the clinical feasibility of the proposed method, a total of 13 lung cancer patient datasets were used for retrospective validation, including 11 cone-beam CT scan pairs and two stereotactic ablative body radiotherapy cases. The ground truths for tumor motion were generated from the the 3D trajectories of implanted markers or beacons. The mean, standard deviation, and 95th percentile of the 3D tracking error were found to range from 1.6-2.9 mm, 0.6-1.5 mm, and 2.6-5.8 mm, respectively. Markerless tumor tracking always resulted in smaller errors compared to the standard of care. The improvement was the most pronounced in the superior-inferior (SI) direction, with up to 9.5 mm reduction in the 95th-percentile SI error for patients with >10 mm 5th-to-95th percentile SI tumor motion. The percentage of errors with 3D magnitude <5 mm was 96.5% for markerless tumor tracking and 84.1% for the standard of care. The feasibility of 3D markerless tumor tracking has been demonstrated on realistic clinical scenarios for the first time. The clinical implementation of the proposed method will enable more accurate and precise lung radiotherapy using existing hardware and workflow. Future work is focused on the clinical and real-time implementation of this method.
[Mh] Termos MeSH primário: Tomografia Computadorizada de Feixe Cônico/métodos
Imagem Tridimensional/métodos
Neoplasias Pulmonares/radioterapia
Radiocirurgia/métodos
Radioterapia Assistida por Computador/métodos
[Mh] Termos MeSH secundário: Algoritmos
Teorema de Bayes
Tomografia Computadorizada de Feixe Cônico/normas
Seres Humanos
Imagem Tridimensional/normas
Movimento (Física)
Imagens de Fantasmas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1088/1361-6560/aa6393


  5 / 2255 MEDLINE  
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[PMID]:28300382
[Au] Autor:Schopfer M; Thomas SJ; Tudor GS; Bourhis J; Bochud F; Moeckli R
[Ad] Endereço:Institute of Radiation Physics, CHUV and University of Lausanne, CH-1007, Lausanne, Switzerland.
[Ti] Título:Implementation of TomoEDGE in the independent dose calculator CheckTomo.
[So] Source:J Appl Clin Med Phys;18(2):92-99, 2017 Mar.
[Is] ISSN:1526-9914
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: CheckTomo is an independent dose calculation software for tomotherapy. Recently, Accuray (Accuray Inc., Sunnyvale, CA, USA) released an upgrade of its tomotherapy treatment device, called TomoEDGE Dynamic Jaws, which improves the quality of treatment plans by enhancing the dose delivery with the help of jaws motion. This study describes the upgrade of CheckTomo to that new feature. METHODS: To account for the varying width and off-axis shift of dynamic jaws fields, the calculation engine of CheckTomo multiplies the treatment field profile by a penumbral filter and shifts the dose calculation grid. Penumbral filters were obtained by dividing the edge field profiles by that of the corresponding nominal field. They were sampled at widths 1.0, 1.8, and 2.5 cm at isocenter in the edges of the 2.5 and 5 cm treatment field. RESULTS: The upgrade of CheckTomo was tested on 30 patient treatments planned with dynamic jaws. The gamma pass rate averaged over 10 abdomen plans was 95.9%, with tolerances of 3 mm/3%. For 10 head and neck plans, the mean pass rate was 95.9% for tolerances of 4 mm/4%. Finally, misplacement and overdosage errors were simulated. In each tested cases, the 2 mm/3% gamma pass rate fell below 95% when a 4 mm shift or 3% dose difference was applied. CONCLUSIONS: These results are equivalent to what CheckTomo achieves in static jaws cases. So, in terms of dose calculation accuracy and errors detection, the upgraded version of CheckTomo is as reliable for dynamic jaws plans as the former release was for static cases.
[Mh] Termos MeSH primário: Neoplasias Abdominais/radioterapia
Neoplasias da Mama/radioterapia
Neoplasias de Cabeça e Pescoço/radioterapia
Técnicas de Fixação da Arcada Osseodentária/instrumentação
Neoplasias Pélvicas/radioterapia
Planejamento da Radioterapia Assistida por Computador/métodos
Software
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Dosagem Radioterapêutica
Radioterapia Assistida por Computador/métodos
Radioterapia de Intensidade Modulada/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE
[do] DOI:10.1002/acm2.12048


  6 / 2255 MEDLINE  
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[PMID]:28249627
[Au] Autor:Brammer C; Dawson D; Joseph M; Tipper J; Jemmet T; Liew L; Spinou C; Grew N; Pigadas N; Rehman K
[Ad] Endereço:Clatterbridge Cancer Centre,Clatterbridge.
[Ti] Título:Adult Co-morbidity Evaluation 27 scores of head and neck cancer patients using touch-screen technology: patient satisfaction and clinical verification.
[So] Source:J Laryngol Otol;131(5):442-446, 2017 May.
[Is] ISSN:1748-5460
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: This study aimed to assess head and neck cancer patient satisfaction with the use of a touch-screen computer patient-completed questionnaire for assessing Adult Co-morbidity Evaluation 27 co-morbidity scores prior to treatment, along with its clinical reliability. METHODS: A total of 96 head and neck cancer patients were included in the audit. An accurate Adult Co-morbidity Evaluation 27 co-morbidity score was achieved via patient-completed questionnaire assessment for 97 per cent of participants. RESULTS: In all, 96 per cent of patients found the use of a touch-screen computer acceptable and would be willing to use one again, and 62 per cent would be willing to do so without help. Patients were more likely to be willing to use the computer again without help if they were aged 65 years or younger (χ2 test; p = 0.0054) or had a performance status of 0 or 1 (χ2 test; p = 0.00034). CONCLUSION: Use of a touch-screen computer is an acceptable approach for assessing Adult Co-morbidity Evaluation 27 scores at pre-treatment assessment in a multidisciplinary joint surgical-oncology clinic.
[Mh] Termos MeSH primário: Coleta de Dados/instrumentação
Documentação/métodos
Neoplasias de Cabeça e Pescoço/psicologia
Satisfação do Paciente
Inquéritos e Questionários
Interface Usuário-Computador
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Comorbidade
Computadores
Autoavaliação Diagnóstica
Desenho de Equipamento
Feminino
Seres Humanos
Masculino
Meia-Idade
Radioterapia Assistida por Computador
Reprodutibilidade dos Testes
Tato
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170412
[Lr] Data última revisão:
170412
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170303
[St] Status:MEDLINE
[do] DOI:10.1017/S0022215116009397


  7 / 2255 MEDLINE  
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[PMID]:28044346
[Au] Autor:Conroy L; Guebert A; Smith WL
[Ad] Endereço:Department of Medical Physics, Tom Baker Cancer Centre, 1331 29 Street NW, Calgary, AB, Canada, T2N 4N2.
[Ti] Título:Technical Note: Issues related to external marker block placement for deep inspiration breath hold breast radiotherapy.
[So] Source:Med Phys;44(1):37-42, 2017 Jan.
[Is] ISSN:2473-4209
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: It has been suggested that the Real-time Position Management (RPM) marker block should be placed directly on the breast or sternum to verify deep inspiration breath hold (DIBH) level for breast radiotherapy. We explore three potential issues with this practice: (a) surface dose effect of placing the marker block in the primary beam; (b) effect of marker block tilt on the accuracy of the RPM system; and (c) correlation between marker block positions on the patient surface and internal chest wall position. METHODS: (a) The surface dose under the two-, four-, and six-dot marker blocks was measured at incident angles of 0° and 30°; (b) the motion amplitude detected when using the two- and six-dot marker blocks was recorded for block tilts from 0° to 60° about the RPM camera line of sight; (c) the correlation between median displacement of the chest wall and median displacement of the surface contour between breath holds was investigated for superior, middle, and inferior block positions using contours extracted from portal images of eight left-sided breast cancer patients. RESULTS: (a) The marker blocks increased the surface dose for a 6 MV direct field by 48.2-52.2% of D ; (b) at lateral tilts greater than 10°, the two-dot marker block overestimated the motion amplitude; however, the six-dot marker block amplitude remained accurate up to 60°; (c) the whole, superior, and middle surface positions were strongly correlated with chest wall displacement (R = 0.83; R = 0.90; R = 0.83), whereas the inferior position was moderately correlated (R = 0.36). CONCLUSIONS: The RPM marker block can be placed on the breast for DIBH treatments; however, caution should be used regarding surface dose effects. The two-dot marker block should not be used for block tilts beyond 20°. Marker block placement at a middle or superior position on the breast results in the strongest correlation with chest wall position.
[Mh] Termos MeSH primário: Mama/efeitos da radiação
Suspensão da Respiração
Marcadores Fiduciais
Radioterapia Assistida por Computador/normas
Respiração
[Mh] Termos MeSH secundário: Neoplasias da Mama/radioterapia
Dosimetria Fotográfica
Seres Humanos
Dosagem Radioterapêutica
Planejamento da Radioterapia Assistida por Computador
Parede Torácica/efeitos da radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170315
[Lr] Data última revisão:
170315
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170104
[St] Status:MEDLINE
[do] DOI:10.1002/mp.12005


  8 / 2255 MEDLINE  
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[PMID]:28041813
[Au] Autor:Su J; Zhu S; Liu Z; Zhao Y; Song C
[Ad] Endereço:Department of Radiation Oncology, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China. Electronic address: 704057795@qq.com.
[Ti] Título:Target volume delineation for radical radiotherapy of early oesophageal carcinoma in elderly patients.
[So] Source:Cancer Radiother;21(1):34-39, 2017 Feb.
[Is] ISSN:1769-6658
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To compare the prognosis of elderly patients with early oesophageal carcinoma between radical elective nodal prophylactic irradiation and involved-field irradiation and to estimate the failure modes and adverse effects, then to provide the patients the safe and individual therapeutic regimens. MATERIAL AND METHODS: The charts of 96 patients aged 65 and over with early stage oesophageal carcinoma receiving radical radiotherapy in our department were retrospectively analysed. Of all the patients, 49 received elective nodal prophylactic irradiation and the other 47 received involved-field irradiation. After completion of the whole treatment, we analysed short-term effects, tumour local control, overall survival of the patients, failure modes and adverse effects. RESULTS: The 1-, 3-, and 5-year local control rate in elective nodal irradiation and involved-field irradiation groups were 80.6%, 57.4%, 54.0% and 65.4%, 46.5%, 30.5% respectively, and the difference was statistically significant (χ =4.478, P=0.03). The differences of overall survival and progression-free survival were not significant (P>0.05). The difference of 1-, 3-, and 5-years local regional failure rate was statistically significant between elective nodal prophylactic irradiation and involved-field irradiation groups, except for the overall failure and distant metastasis rates. The overall incidence of radiation-induced oesophagitis after elective nodal irradiation or involved-field irradiation was 79.6% and 59.6%, and the difference was statistically significant (χ =4.559, P=0.03). The difference of radiation pneumonitis between elective nodal prophylactic irradiation and involved-field irradiation was not significant (12.2% vs 14.9%; χ =0.144, P=0.7). CONCLUSION: For elderly patients with early stage oesophageal carcinoma receiving radical radiotherapy, although elective nodal prophylactic irradiation could increase the incidence of radiation-induced oesophagitis, patients could tolerate the treatment and benefit from local control.
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/radioterapia
Neoplasias Esofágicas/radioterapia
Metástase Linfática/radioterapia
Radioterapia Assistida por Computador/métodos
Radioterapia Conformacional/métodos
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Carcinoma/tratamento farmacológico
Carcinoma/mortalidade
Carcinoma/radioterapia
Carcinoma de Células Escamosas/tratamento farmacológico
Carcinoma de Células Escamosas/mortalidade
Cisplatino/administração & dosagem
Terapia Combinada
Intervalo Livre de Doença
Neoplasias Esofágicas/tratamento farmacológico
Neoplasias Esofágicas/mortalidade
Feminino
Fluoruracila/administração & dosagem
Seres Humanos
Estimativa de Kaplan-Meier
Metástase Linfática/prevenção & controle
Masculino
Órgãos em Risco
Pneumonite por Radiação/epidemiologia
Pneumonite por Radiação/etiologia
Radioterapia Conformacional/efeitos adversos
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
Q20Q21Q62J (Cisplatin); U3P01618RT (Fluorouracil)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170103
[St] Status:MEDLINE


  9 / 2255 MEDLINE  
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[PMID]:27909957
[Au] Autor:Veresezan O; Troussier I; Lacout A; Kreps S; Maillard S; Toulemonde A; Marcy PY; Huguet F; Thariat J
[Ad] Endereço:Oncology Radiotherapy, Centre Henri Becquerel, Rouen, France.
[Ti] Título:Adaptive radiation therapy in head and neck cancer for clinical practice: state of the art and practical challenges.
[So] Source:Jpn J Radiol;35(2):43-52, 2017 Feb.
[Is] ISSN:1867-108X
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Modern radiation therapy techniques are characterized by high conformality to tumor volumes and steep dose gradients to spare normal organs. These techniques require accurate clinical target volume definitions and rigorous assessment of set up uncertainties using image guidance, a concept called image-guided radiation therapy. Due to alteration of patient anatomy, changes in tissue density/volumes and tumor shrinkage over the course of treatment, treatment accuracy may be challenged. This may result in excessive irradiation of organs at risk/healthy tissues and undercoverage of target volumes with a significant risk of locoregional failure. Adaptive radiation therapy (ART) is a concept allowing the clinician to reconsider the planned dose based on potential changes to accurately delivering the remaining radiation dose to the tumor while optimally minimizing irradiation of healthy tissues. There is little consensus on how to apply this concept in clinical practice. The current review investigates the current ART issues, including patient selection, clinical/dosimetric criteria and timing for re-planning, and practical technical issues. A practical algorithm is proposed for patient management in cases where ART is required.
[Mh] Termos MeSH primário: Neoplasias de Cabeça e Pescoço/radioterapia
Planejamento da Radioterapia Assistida por Computador/métodos
Radioterapia Assistida por Computador/métodos
[Mh] Termos MeSH secundário: Seres Humanos
Dosagem Radioterapêutica
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171104
[Lr] Data última revisão:
171104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161203
[St] Status:MEDLINE
[do] DOI:10.1007/s11604-016-0604-9


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[PMID]:27759420
[Au] Autor:Qureshi BM; Abbasi AN; Ali N; Hafiz A
[Ad] Endereço:Section of Radiation Oncology, Department of Oncology, Aga Khan University, Karachi, Pakistan.
[Ti] Título:Nasopharyngeal carcinoma (NPC)-issues in the inclusion of cervical nodal region in radiation treatment volume.
[So] Source:Br J Radiol;90(1069):20160726, 2017 Jan.
[Is] ISSN:1748-880X
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Neoplasias de Cabeça e Pescoço/radioterapia
Linfonodos/efeitos da radiação
Neoplasias Nasofaríngeas/radioterapia
Radioterapia de Intensidade Modulada
[Mh] Termos MeSH secundário: Carcinoma
Feminino
Neoplasias de Cabeça e Pescoço/diagnóstico
Seres Humanos
Linfonodos/patologia
Metástase Linfática
Masculino
Neoplasias Nasofaríngeas/diagnóstico
Radioterapia Assistida por Computador
Sensibilidade e Especificidade
[Pt] Tipo de publicação:LETTER
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161021
[St] Status:MEDLINE
[do] DOI:10.1259/bjr.20160726



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