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[PMID]:29447173
[Au] Autor:Diao YF; Lin T; Li X; Oqani RK; Lee JE; Kim SY; Jin DI
[Ad] Endereço:Institute of Special Animal & Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun, China.
[Ti] Título:Dynamic changes of SETD2, a histone H3K36 methyltransferase, in porcine oocytes, IVF and SCNT embryos.
[So] Source:PLoS One;13(2):e0191816, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:SETD2 (SET domain containing protein 2) acts as a histone H3 lysine 36 (H3K36)-specific methyltransferase and may play important roles in active gene transcription in human cells. However, its expression and role in porcine oocytes and preimplantation embryos are not well understood. Here, we used immunofluorescence and laser scanning confocal microscopy to examine SETD2 expression in porcine fetal fibroblasts, oocytes, and preimplantation embryos derived from in vitro fertilization (IVF), parthenogenetic activation (PA), and somatic cell nuclear transfer (SCNT). In porcine fetal fibroblasts, SETD2 expression was detected in interphase cells, but not in M (mitotic)-phase cells. The SETD2 signal was observed in non-surrounded nucleolus (NSN)-stage oocytes, but not in surrounded nucleolus (SN)-, metaphase I (MI)-, or metaphase II (MII)-stage oocytes. The SETD2 signal was detectable in sperm, and undetectable immediately after fertilization, detectable at the 2-cell stage, and peaked at the 4-cell stage of IVF embryos in which porcine embryonic genome is activated. Similar to the pattern found in IVF embryos, the SETD2 signal was absent from PA embryos at the 1-cell stage, but it was detected at the 2-cell stage and thereafter maintained to the blastocyst stage. Interestingly, unlike the IVF and PA embryos, the SETD2 signal was detected throughout the development of SCNT embryos, including at the 1-cell stage. These data suggest that SETD2 may be functional for embryonic gene transcription in porcine preimplantation embryos. It is further speculated that the aberrant expression of SETD2 at the 1-cell stage of porcine SCNT embryos may be a factor in the low efficiency of cloning in pig.
[Mh] Termos MeSH primário: Fertilização In Vitro
Histona-Lisina N-Metiltransferase/metabolismo
Técnicas de Transferência Nuclear
Oócitos/enzimologia
[Mh] Termos MeSH secundário: Animais
Blastocisto
Células Cultivadas
Oócitos/citologia
Partenogênese
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
EC 2.1.1.43 (Histone-Lysine N-Methyltransferase)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180216
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191816


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[PMID]:29256287
[Au] Autor:Suttirojpattana T; Somfai T; Matoba S; Nagai T; Parnpai R; Geshi M
[Ad] Endereço:1 Embryo Technology and Stem Cell Research Center, Suranaree University of Technology , Nakhon Ratchasima , Thailand.
[Ti] Título:Effect of storage tube material and resveratrol during liquid storage of matured bovine oocytes on subsequent development.
[So] Source:Acta Vet Hung;65(4):546-555, 2017 12.
[Is] ISSN:0236-6290
[Cp] País de publicação:Hungary
[La] Idioma:eng
[Ab] Resumo:This study determined the optimum storage vessel and the effects of resveratrol for the storage of in vitro matured (IVM) bovine oocytes. After IVM, the oocytes were kept in a Hepes-buffered medium at 25 °C for 20 h in different containers including Eppendorf tubes (ET) made of polypropylene (PP) and polystyrene (PS), and tissue culture tubes (TCT) made of PP, PS, and glass. Then oocytes were subjected to IVF and subsequent in vitro embryo development was compared among the groups and to that of a control group without storage. The percentage of blastocyst development in the control group was significantly higher than in the stored groups (P < 0.05). Among oocytes stored in TCT, the percentage of blastocyst development of oocytes stored in glass TCT was significantly higher than that of oocytes stored in PP and PS TCT (P < 0.05); however, it did not differ from that of oocytes stored in ET. The quality of blastocysts did not differ among the control and stored groups. Embryo development was not affected when 0.1, 1 or 10 µM resveratrol was added to the medium during oocyte storage. In conclusion, glass tubes were optimal for oocyte storage and resveratrol did not improve the development of stored oocytes.
[Mh] Termos MeSH primário: Bovinos
Fertilização In Vitro/veterinária
Técnicas de Maturação in Vitro de Oócitos/veterinária
Oócitos/efeitos dos fármacos
Oócitos/fisiologia
Estilbenos/farmacologia
[Mh] Termos MeSH secundário: Animais
Antioxidantes/farmacologia
Blastocisto/fisiologia
Preservação de Tecido
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Stilbenes); Q369O8926L (resveratrol)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.1556/004.2017.053


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[PMID]:28455751
[Au] Autor:Hipp H; Crawford S; Kawwass JF; Boulet SL; Grainger DA; Kissin DM; Jamieson D
[Ad] Endereço:Division of Reproductive Endocrinology and Infertility, Emory University School of Medicine, Emory University, 550 Peachtree Street, Suite 1800, Atlanta, GA, 30308, USA. hhipp@emory.edu.
[Ti] Título:National trends and outcomes of autologous in vitro fertilization cycles among women ages 40 years and older.
[So] Source:J Assist Reprod Genet;34(7):885-894, 2017 Jul.
[Is] ISSN:1573-7330
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The purpose of the study was to describe trends in and investigate variables associated with clinical pregnancy and live birth in autologous in vitro fertilization (IVF) cycles among women ≥40 years. METHODS: We used autologous IVF cycle data from the National ART Surveillance System (NASS) for women ≥40 years at cycle start. We assessed trends in fresh and frozen cycles (n = 371,536) from 1996 to 2013. We reported perinatal outcomes and determined variables associated with clinical pregnancy and live birth in fresh cycles between 2007 and 2013. RESULTS: From 1996 to 2013, the total number of cycles in women ≥40 years increased from 8672 to 28,883 (p < 0.0001), with frozen cycles almost tripling in the last 8 years. Cycles in women ≥40 years accounted for 16.0% of all cycles in 1996 and 21.0% in 2013 (p < 0.0001). For fresh cycles from 2007 to 2013 (n = 157,890), the cancelation rate was 17.1%. Among cycles resulting in transfer (n = 112,414), the live birth rate was 16.1%. The following were associated with higher live birth rates: multiparity, fewer prior ART cycles, use of standard agonist or antagonist stimulation, lower gonadotropin dose, ovarian hyperstimulation syndrome, more oocytes retrieved, use of pre-implantation genetic screening/diagnosis, transferring more and/or blastocyst stage embryos, and cryopreserving more supernumerary embryos. Of the singleton infants born (n = 14,992), 86.9% were full term and 88.3% normal birth weight. CONCLUSIONS: The NASS allows for a comprehensive description of IVF cycles in women ≥40 years in the USA. Although live birth rate is less than 20%, identifying factors associated with IVF success can facilitate treatment option counseling.
[Mh] Termos MeSH primário: Fertilização In Vitro/tendências
Taxa de Gravidez
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Centers for Disease Control and Prevention (U.S.)
Feminino
Fertilização In Vitro/estatística & dados numéricos
Seres Humanos
Infertilidade/terapia
Gravidez
Resultado do Tratamento
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1007/s10815-017-0926-2


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[PMID]:29424977
[Au] Autor:Santibáñez-Morales A; Durán-Boullosa E; Colín-Licea EO
[Ti] Título:[Use of growth hormone for in vitro fertilization].
[Ti] Título:Indicación de hormona de crecimiento en ciclos de fertilización in vitro..
[So] Source:Ginecol Obstet Mex;84(9):567-72, 2016 Sep.
[Is] ISSN:0300-9041
[Cp] País de publicação:Mexico
[La] Idioma:spa
[Ab] Resumo:Background: Ovarian stimulation is the cornerstone in fertility treatments, it produces multifolicular development and in consequence, a greater pregnancy rate. Poor responder patients have bad outcomes in IVF, several medical approaches have been proposed in managing these patients, including Growth Hormone. Objetive: To report our results with the use of growth hormone and review published data. Material and method: Case series conducted from January 2013 to May 2015 in patients to Centro de Reproducción PROCREA, Mexico City, poor responders according to the criteria of consensus Bologna cycles in fresh stimulation protocol Flare up, application of growth hormone as adjuvant, complete cycles of stimulation (stimulation, oocyte capture, and embryo transfer pregnancy test) and complete records. For statistical analysis, averages and percentages were used. Results: 40 cases were analyzed. Age and BMI were 39.1 ± 2.1 years and 24.6 ± 2.8 kg/m2, respectively. Total gonadotrophin dose was 2128.6 ± 1078.9 UI, retrieved oocytes and fertilized eggs were 7.1 ± 4.0 y 5.4 ± 2.8 respectively. Fertilization rate was 76.3% and pregnancy rate was 59.5%. Conclusion: There is insufficient evidence for prescribing GH in all patients requiring IVF, nevertheless, in poor responder patients, there seems to be an improvement in egg quality leading to better fertilization and pregnancy rate, with no adverse effects.
[Mh] Termos MeSH primário: Fertilização In Vitro/métodos
Hormônio do Crescimento/administração & dosagem
Indução da Ovulação/métodos
[Mh] Termos MeSH secundário: Adulto
Feminino
Gonadotropinas/administração & dosagem
Seres Humanos
México
Gravidez
Taxa de Gravidez
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gonadotropins); 9002-72-6 (Growth Hormone)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180210
[St] Status:MEDLINE


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Registro de Ensaios Clínicos
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[PMID]:29320655
[Au] Autor:Vuong LN; Dang VQ; Ho TM; Huynh BG; Ha DT; Pham TD; Nguyen LK; Norman RJ; Mol BW
[Ad] Endereço:From the Department of Obstetrics and Gynecology, University of Medicine and Pharmacy at Ho Chi Minh City (L.N.V.), IVFMD, My Duc Hospital (L.N.V., V.Q.D., T.M.H., B.G.H., T.D.P., L.K.N.), and the Research Center for Genetics and Reproductive Health, School of Medicine, Vietnam National University (
[Ti] Título:IVF Transfer of Fresh or Frozen Embryos in Women without Polycystic Ovaries.
[So] Source:N Engl J Med;378(2):137-147, 2018 01 11.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Among women who are undergoing in vitro fertilization (IVF), the transfer of frozen embryos has been shown to result in a higher rate of live birth than the transfer of fresh embryos in those with infertility associated with the polycystic ovary syndrome. It is not known whether frozen-embryo transfer results in similar benefit in women with infertility that is not associated with the polycystic ovary syndrome. METHODS: We randomly assigned 782 infertile women without the polycystic ovary syndrome who were undergoing a first or second IVF cycle to receive either a frozen embryo or a fresh embryo on day 3. In the frozen-embryo group, all grade 1 and 2 embryos had been cryopreserved, and a maximum of two embryos were thawed on the day of transfer in the following cycle. In the fresh-embryo group, a maximum of two fresh embryos were transferred in the stimulated cycle. The primary outcome was ongoing pregnancy after the first embryo transfer. RESULTS: After the first completed cycle, ongoing pregnancy occurred in 142 of 391 women (36.3%) in the frozen-embryo group and in 135 of 391 (34.5%) in the fresh-embryo group (risk ratio in the frozen-embryo group, 1.05; 95% confidence interval [CI], 0.87 to 1.27; P=0.65). Rates of live birth after the first transfer were 33.8% and 31.5%, respectively (risk ratio, 1.07; 95% CI, 0.88 to 1.31). CONCLUSIONS: Among infertile women without the polycystic ovary syndrome who were undergoing IVF, the transfer of frozen embryos did not result in significantly higher rates of ongoing pregnancy or live birth than the transfer of fresh embryos. (Funded by My Duc Hospital; ClinicalTrials.gov number, NCT02471573 .).
[Mh] Termos MeSH primário: Criopreservação
Transferência Embrionária
Fertilização In Vitro
Infertilidade Feminina
Taxa de Gravidez
[Mh] Termos MeSH secundário: Adulto
Transferência Embrionária/métodos
Feminino
Seres Humanos
Recém-Nascido
Análise de Intenção de Tratamento
Nascimento Vivo
Indução da Ovulação
Síndrome do Ovário Policístico
Gravidez
Complicações na Gravidez
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180111
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMoa1703768


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[PMID]:29315321
[Au] Autor:Gu YF; Zhou QW; Zhang SP; Lu CF; Gong F; Tan YQ; Lu GX; Lin G
[Ad] Endereço:Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, China.
[Ti] Título:Inner cell mass incarceration in 8-shaped blastocysts does not increase monozygotic twinning in preimplantation genetic diagnosis and screening patients.
[So] Source:PLoS One;13(1):e0190776, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The use of assisted reproductive technology (ART) has been reported to increase the incidence of monozygotic twinning (MZT) compared with the incidence following natural conception. It has been hypothesized that splitting of the inner cell mass (ICM) through a small zona hole may result in MZT. In this study, using a cohort of patients undergoing preimplantation genetic diagnosis/screening (PGD/PGS), we compared the clinical and neonatal outcomes of human 8-shaped blastocysts hatching with ICM incarceration with partially or fully hatched blastocysts, and attempted to verify whether this phenomenon increases the incidence of MZT pregnancy or negatively impact newborns. METHODS: This retrospective study included 2059 patients undergoing PGD/PGS between March 1, 2013, and December 31, 2015. Clinical and neonatal outcomes were only collected from patients who received a single blastocyst transfer after PGD/PGS (n = 992). A 25- to 30-µm hole was made in the zona of day 3 embryos by laser. The blastocysts were biopsied and vitrified on day 6. The biopsied trophectoderm (TE) cells were analyzed using different genetic methods. One tested blastocyst was thawed and transferred to each patient in the subsequent frozen embryo transfer cycle. All the biopsied blastocysts were divided into three types: 8-shaped with ICM incarceration (type I), partially hatched without ICM incarceration (type II), and fully hatched (type III). ICM/TE grading, clinical and neonatal outcomes were compared between the groups. RESULTS: The percentage of grade A ICMs in type I blastocysts (22.2%) was comparable to that in type III blastocysts (20.1%) but higher than that in type II blastocysts (4.5%). The percentage of grade A TEs in type I blastocysts (4.2%) was comparable to that in type II (3.6%) but lower than that in type III (13.5%). There were no significant differences in clinical pregnancy, MZT pregnancy, miscarriage, live birth, MZT births, and neonatal outcomes between the groups. CONCLUSIONS: Compared to partially and fully hatched blastocysts, 8-shaped blastocysts with ICM incarceration showed relatively higher ICM and lower TE grades. ICM incarceration in 8-shaped blastocysts does not increase the incidence of MZT and has no negative effects on newborns in PGD/PGS patients.
[Mh] Termos MeSH primário: Massa Celular Interna do Blastocisto
Diagnóstico Pré-Implantação/métodos
Gêmeos Monozigóticos
[Mh] Termos MeSH secundário: Feminino
Fertilização In Vitro
Seres Humanos
Recém-Nascido
Inseminação Artificial
Gravidez
Resultado da Gravidez
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190776


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[PMID]:29374883
[Au] Autor:Lyu XD; Qiao J
[Ad] Endereço:Center of Reproductive Medicine, Peking University Third Hospital, Beijing 100191, China.
[Ti] Título:[Analysis of pregnancy outcomes of polycystic ovary syndrome patients after frozen embryo transfer].
[So] Source:Zhonghua Fu Chan Ke Za Zhi;53(1):31-34, 2018 Jan 25.
[Is] ISSN:0529-567X
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To investigate pregnancy outcomes of the patients with polycystic ovary syndrome (PCOS) after frozen embryo transfer (FET) . Data of 2 367 PCOS patients received in vitro fertilization-embryo transfer [including fresh embryo transfer (fET) and FET] from January 2009 to December 2015 in Peking University Third Hospital were evaluated retrospectively. The basal characteristics, pregnancy complications and outcomes were analyzed, then identified the relative factors followed. Totally 2 367 patients received in vitro fertilization-embryo transfer: 1 106 were treated with fET, and the rest 1 261 cases were treated with FET. The incidence of gestational diabetes mellitus (GDM) was lower in FET group [4.04%(51/1 261) versus 6.15%(68/1 106)], the difference was statistically significant ( 0.05). Singletons born after FET had higher birth weight than fET [(3 406±548) versus (3 360±533) g], the difference was statistically significant ( 0.05). There was no difference of other pregnancy complications between the two groups (all 0.05). fET was an independent risk factor for GDM (adjusted 1.570, 95% 1.075-2.294). Compared with fET, FET could decrease the risk of GDM and receive better neonatal outcomes in patients with PCOS.
[Mh] Termos MeSH primário: Criopreservação
Transferência Embrionária/métodos
Fertilização In Vitro/métodos
Infertilidade Feminina/terapia
Síndrome do Ovário Policístico/terapia
Complicações na Gravidez/epidemiologia
Resultado da Gravidez
[Mh] Termos MeSH secundário: Peso ao Nascer
Diabetes Gestacional/epidemiologia
Feminino
Seres Humanos
Incidência
Infertilidade Feminina/etiologia
Síndrome do Ovário Policístico/complicações
Gravidez
Taxa de Gravidez
Estudos Retrospectivos
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180129
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-567X.2018.01.007


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[PMID]:29374882
[Au] Autor:Li Y; Tan JQ; Mai ZY; Yang DZ
[Ad] Endereço:Center for Reproductive Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
[Ti] Título:[Value of anti-Müllerian hormone in predicting pregnant outcomes of polycystic ovary syndrome patients undergone assisted reproductive technology].
[So] Source:Zhonghua Fu Chan Ke Za Zhi;53(1):23-30, 2018 Jan 25.
[Is] ISSN:0529-567X
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:Explore the value of anti-Müllerian hormone (AMH) in predicting pregnant outcomes of polycystic ovary syndrome (PCOS) patients undergone assisted reproductive technology. The study totally recruited 1 697 patients who underwent the first in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycle in Sun Yat-sen Memorial Hospital from the January 2014 to December 2015. The patients were divided into two groups based on the age<35 ( 758) and ≥35 years old ( 939) , compare the basic data and pregnant outcomes of controlled ovarian hyerstimulation. Spearman correlation method was conducted to analyze the relations between AMH and clinical outcomes. The logistic regression method and partial correlation analysis were used to judge the main factors which determine pregnancy outcomes by controlled the confounding factors. The receiver operating characteristic curve (ROC) was used to evaluate the predictive sensitivity and specificity of AMH. In the group of PCOS patient younger than 35 years, AMH were correlated with the number of antral follicles ( 0.388) and retrieved oocytes ( 0.235) . When the effect of total dosage and starting dosage of gonadotropin were controlled, AMH was still significantly associated with the number of retrieved oocytes ( 0.05) . AMH had no predictive value for the clinical pregnancy of PCOS patient younger than 35 years (area under ROC curve=0.481, 0.768) . In the group of PCOS patient≥35 years old, AMH were correlated with the number of antral follicles ( 0.450) , retrieved oocytes ( 0.399) , available embryo ( 0.336) and high quality embryo ( 0.235) . When the effect of total dosage and starting dosage of gonadotropin were controlled, the correlations were still significant between those indexes (all 0.05) . AMH had no predictive value for the clinical pregnancy of PCOS patient ≥35 years old (area under ROC curve=0.535, 0.560) . However, the clinical pregnancy rate of the group of PCOS patient ≥35 years old was slightly higher than the control group ( 0.062) . AMH has no predictive value for the pregnancy outcome of PCOS patient. The pregnancy rate of PCOS patient ≥35 years old is slightly higher than the younger group, because the PCOS patient may have better ovarian reserve.
[Mh] Termos MeSH primário: Hormônio Antimülleriano/sangue
Fertilização In Vitro/métodos
Síndrome do Ovário Policístico/sangue
Síndrome do Ovário Policístico/metabolismo
Síndrome do Ovário Policístico/terapia
Resultado da Gravidez
Técnicas de Reprodução Assistida
[Mh] Termos MeSH secundário: Adolescente
Adulto
Fatores Etários
Hormônio Antimülleriano/metabolismo
Feminino
Seres Humanos
Folículo Ovariano/metabolismo
Gravidez
Taxa de Gravidez
Prognóstico
Curva ROC
Sensibilidade e Especificidade
Injeções de Esperma Intracitoplásmicas
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
80497-65-0 (Anti-Mullerian Hormone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180129
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-567X.2018.01.006


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[PMID]:29374881
[Au] Autor:Wei DM; Zhang ZZ; Wang Z; Li P; Wang JF; Liu YJ; Zhang JT; Shi YH
[Ad] Endereço:Reproductive Endocrinology Department, The Center for Reproductive Medicine, Shandong University, Jinan 250021, China.
[Ti] Título:[Effect of hyperandrogenism on obstetric complications of singleton pregnancy from in vitro fertilization in women with polycystic ovary syndrome].
[So] Source:Zhonghua Fu Chan Ke Za Zhi;53(1):18-22, 2018 Jan 25.
[Is] ISSN:0529-567X
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To compare the difference in risks of obstetric complications of singleton pregnancy between women with hyperandrogenic polycystic ovary syndrome (PCOS) and women with normoandrogenic PCOS. Prospective cohort study. This study was a secondary analysis of data collected during a multicenter randomized controlled clinical trial. Women who got clinical singleton pregnancy were grouped according to whether they were diagnosed with hyperandrogenism at baseline. There were 118 women with hyperandrogenism and 366 women without hyperandrogenism. The incidences of obstetric complications and birth weight were compared between the two groups. Women with hyperandrogenic PCOS had a significantly higher risk of preterm delivery than women with normoandrogenic PCOS [12.7% (15/118) versus 3.6% (13/366); 3.94, 95% 1.82-8.56]. After adjustment of age, duration of infertility, body mass index, and fresh or frozen embryo transfer group, hyperandrogenism was still associated with an increased risk of preterm delivery ( 3.67, 95% 1.67-8.07). Compared with women with normoandrogenic PCOS, women with hyperandrogenic PCOS had similar risks of pregnancy loss, gestational diabetes mellitus, pre-eclampsia, placenta previa, and postpartum hemorrhage (all 0.05). Birth weight as well as the risks of being small for gestational age and large for gestational age were also comparable between the two groups (all 0.05). In women with PCOS and singleton pregnancy, those with preconceptional hyperandrogenism have a higher risk of preterm delivery than those without hyperandrogenism.
[Mh] Termos MeSH primário: Peso ao Nascer
Hiperandrogenismo/epidemiologia
Síndrome do Ovário Policístico/epidemiologia
Nascimento Prematuro/epidemiologia
[Mh] Termos MeSH secundário: Aborto Espontâneo/epidemiologia
Índice de Massa Corporal
Diabetes Gestacional/epidemiologia
Feminino
Fertilização In Vitro
Idade Gestacional
Seres Humanos
Recém-Nascido
Recém-Nascido Pequeno para a Idade Gestacional
Pré-Eclâmpsia/epidemiologia
Gravidez
Complicações na Gravidez/epidemiologia
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180129
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-567X.2018.01.005


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[PMID]:29390463
[Au] Autor:Ng KK; Rozen G; Stewart T; Agresta F; Polyakov A
[Ad] Endereço:Melbourne Medical School, University of Melbourne.
[Ti] Título:A double-blinded, randomized, placebo-controlled trial assessing the effects of nifedipine on embryo transfer: Study protocol.
[So] Source:Medicine (Baltimore);96(51):e9194, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Implantation failure is the main factor affecting the success rate of in vitro fertilization (IVF) procedures. Studies have reported that uterine contractions (UCs) at the time of embryo transfer (ET) were inversely related to implantation and pregnancy rate, hence reducing the success of IVF treatment. Various pharmacological agents, with the exception of calcium channel blocker (CCB), have been investigated to reduce UC. In this regard, we are presenting a proposal for a double-blind randomized placebo-controlled trial. The trial aims to determine whether nifedipine, a CCB with potent smooth muscle relaxing activity and an excellent safety profile, can improve the outcome of ET. METHODS AND ANALYSES: We will recruit 100 infertile women into one of 2 groups: placebo (n = 50) and nifedipine 20 mg (n = 50). Study participants will be admitted 30 minutes prior to ET and given either tablet after their baseline vital signs have been recorded. They will then undergo ET and be observed for adverse events for another 30 minutes post-ET. The primary outcome will be implantation rate and clinical pregnancy rate. Secondary outcomes include adverse events, miscarriage and pregnancy, and neonatal outcomes. Resulting data will then be analyzed using t test, Chi-square test, and multivariate test to compare outcomes between the 2 groups for any statistical significance. This protocol has been designed in accordance with the SPIRIT 2013 Guidelines.
[Mh] Termos MeSH primário: Transferência Embrionária
Fertilização In Vitro/efeitos dos fármacos
Infertilidade Feminina/tratamento farmacológico
Nifedipino/administração & dosagem
Resultado da Gravidez
Taxa de Gravidez
[Mh] Termos MeSH secundário: Distribuição de Qui-Quadrado
Método Duplo-Cego
Feminino
Seres Humanos
Idade Materna
Análise Multivariada
Nifedipino/efeitos adversos
Gravidez
Medição de Risco
Tocolíticos/administração & dosagem
Tocolíticos/efeitos adversos
Vitória
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE I; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Tocolytic Agents); I9ZF7L6G2L (Nifedipine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009194



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