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[PMID]:29381759
[Au] Autor:Narayan E; Sawyer G; Parisella S
[Ad] Endereço:School of Science and Health, Western Sydney University, Locked Bag 1797, Penrith, New South Wales, Australia.
[Ti] Título:Faecal glucocorticoid metabolites and body temperature in Australian merino ewes (Ovis aries) during summer artificial insemination (AI) program.
[So] Source:PLoS One;13(1):e0191961, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Reproductive wastage is a key issue for sheep producers, both regionally and globally. The reproductive output of farm animals can be influenced by physiological and environmental factors. Rapid and reliable quantification of physiological stress can provide a useful tool for designing and testing on-farm management interventions to improve farm animal welfare and productivity. In this study, we quantified physiological stress non-invasively using faecal glucocorticoid metabolites-FGMs analysis and body temperature measurements of 15 superovulated donor merino ewes (Ovis aries) during participation in artificial insemination (AI) program conducted during 2015/2016 Australian summer. We hypothesized that low percentage transferable embryos in donor merino ewes will be associated positively with higher body temperature and/or higher FGMs in these ewes. Temperature humidity index (THI) was calculated and found within high thermal stress range during the two AI trials. Overall, results showed none of the factors (ewe ID, AI trial no., THI or FGMs) were significant for reduced percentage transferrable embryos, except ewe body temperature was highly significant (p = 0.014). Within AI trial comparisons showed significant positive associations between higher FGMs and body temperature with reduced transferrable embryos. These results suggest that Australian merino ewes participating in summer AI trials can experience physiological stress. Prolonged activation of the stress endocrine response and high body temperature (e.g. ensued from heat stress) could impact on ewe reproductive output. Therefore, future research should apply minimally invasive physiological tools to gather baseline information on physiological stress in merino sheep to enable the development of new farm-friendly methods of managing stress.
[Mh] Termos MeSH primário: Fezes
Glucocorticoides/metabolismo
Inseminação Artificial
[Mh] Termos MeSH secundário: Animais
Austrália
Clima
Feminino
Técnicas Imunoenzimáticas
Estações do Ano
Ovinos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Glucocorticoids)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180131
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191961


  2 / 8720 MEDLINE  
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[PMID]:29315321
[Au] Autor:Gu YF; Zhou QW; Zhang SP; Lu CF; Gong F; Tan YQ; Lu GX; Lin G
[Ad] Endereço:Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, China.
[Ti] Título:Inner cell mass incarceration in 8-shaped blastocysts does not increase monozygotic twinning in preimplantation genetic diagnosis and screening patients.
[So] Source:PLoS One;13(1):e0190776, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The use of assisted reproductive technology (ART) has been reported to increase the incidence of monozygotic twinning (MZT) compared with the incidence following natural conception. It has been hypothesized that splitting of the inner cell mass (ICM) through a small zona hole may result in MZT. In this study, using a cohort of patients undergoing preimplantation genetic diagnosis/screening (PGD/PGS), we compared the clinical and neonatal outcomes of human 8-shaped blastocysts hatching with ICM incarceration with partially or fully hatched blastocysts, and attempted to verify whether this phenomenon increases the incidence of MZT pregnancy or negatively impact newborns. METHODS: This retrospective study included 2059 patients undergoing PGD/PGS between March 1, 2013, and December 31, 2015. Clinical and neonatal outcomes were only collected from patients who received a single blastocyst transfer after PGD/PGS (n = 992). A 25- to 30-µm hole was made in the zona of day 3 embryos by laser. The blastocysts were biopsied and vitrified on day 6. The biopsied trophectoderm (TE) cells were analyzed using different genetic methods. One tested blastocyst was thawed and transferred to each patient in the subsequent frozen embryo transfer cycle. All the biopsied blastocysts were divided into three types: 8-shaped with ICM incarceration (type I), partially hatched without ICM incarceration (type II), and fully hatched (type III). ICM/TE grading, clinical and neonatal outcomes were compared between the groups. RESULTS: The percentage of grade A ICMs in type I blastocysts (22.2%) was comparable to that in type III blastocysts (20.1%) but higher than that in type II blastocysts (4.5%). The percentage of grade A TEs in type I blastocysts (4.2%) was comparable to that in type II (3.6%) but lower than that in type III (13.5%). There were no significant differences in clinical pregnancy, MZT pregnancy, miscarriage, live birth, MZT births, and neonatal outcomes between the groups. CONCLUSIONS: Compared to partially and fully hatched blastocysts, 8-shaped blastocysts with ICM incarceration showed relatively higher ICM and lower TE grades. ICM incarceration in 8-shaped blastocysts does not increase the incidence of MZT and has no negative effects on newborns in PGD/PGS patients.
[Mh] Termos MeSH primário: Massa Celular Interna do Blastocisto
Diagnóstico Pré-Implantação/métodos
Gêmeos Monozigóticos
[Mh] Termos MeSH secundário: Feminino
Fertilização In Vitro
Seres Humanos
Recém-Nascido
Inseminação Artificial
Gravidez
Resultado da Gravidez
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190776


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[PMID]:27771115
[Au] Autor:Abel JM; Bishop BE; Thomas JM; Ellersieck MR; Poock SE; Smith MF; Patterson DJ
[Ad] Endereço:Division of Animal Sciences, University of Missouri, Columbia, Missouri, USA; College of Veterinary Medicine, University of Missouri, Columbia, Missouri, USA.
[Ti] Título:Comparing strategies to synchronize estrus before fixed-time artificial insemination in primiparous 2-year-old beef cows.
[So] Source:Theriogenology;87:306-315, 2017 Jan 01.
[Is] ISSN:1879-3231
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Two experiments evaluated controlled internal drug release (CIDR)-based protocols to synchronize estrus in primiparous 2-year-old beef cows. In each experiment, treatments were balanced according to body condition score and days postpartum. Experiment 1 compared the 14-day CIDR-PG (14-d) and 7-day CO-Synch + CIDR (7-d) protocols on the basis of estrous response, pregnancy rates after fixed-time artificial insemination (FTAI), and final pregnancy rate. Cows assigned to 14-d (n = 355) received a CIDR insert on Day 0 with removal on Day 14. Cows assigned to 7-d (n = 349) received gonadotropin releasing hormone (GnRH) and a CIDR insert on Day 23. On Day 30, CIDRs were removed from 7-d cows, and PGF was administered to all cows in each treatment. On Day 33, GnRH was administered concurrent with FTAI at 66 and 72 hours after PGF for 7-d and 14-d treated cows, respectively. Estrous response before FTAI was higher for 7-d compared with 14-d cows (74% vs. 43%, respectively; P < 0.0001); however, pregnancy rates resulting from FTAI were similar (14-d 63%; 7-d 64%; P = 0.52). Ovarian follicular dynamics and serum estradiol-17ß concentrations were evaluated among a subset of cows assigned to each protocol. Dominant follicle diameter was smaller at PGF (P = 0.04) and FTAI (P = 0.002) among 14-d cows compared with 7-d cows; however, estradiol-17ß at PGF (P = 0.06) and FTAI (P = 0.001) was greater for 14-d versus 7-d treated cows. Experiment 2 compared estrous response and pregnancy rates in 2-year-old beef cows after FTAI- or split-time artificial insemination (STAI) following synchronization of estrus with the 14-day protocol. Cows assigned to FTAI (n = 266) were inseminated at a fixed time concurrent with GnRH at 72 hours after PGF regardless of estrus expression, whereas cows assigned to STAI (n = 257) were inseminated based on estrus expression as determined by activation of an estrus detection aid. Cows assigned to STAI that exhibited estrus by 72 hours were inseminated; however, AI was delayed until 24 hours after GnRH (96 hours after PGF ) for nonestrous cows. Total estrous response was increased for STAI- versus FTAI-treated cows (STAI 64%; FTAI 42%; P < 0.0001); pregnancy rates resulting from AI were similar (STAI 55%; FTAI 56%; P = 0.60). In summary, the 14-day CIDR-PG and 7-day CO-Synch + CIDR protocols can be used effectively to synchronize estrus before FTAI in primiparous 2-year-old beef cows. Although expression of estrus was increased using STAI in conjunction with the 14-day protocol, this approach did not increase pregnancy rates compared with FTAI.
[Mh] Termos MeSH primário: Bovinos
Sincronização do Estro/métodos
Inseminação Artificial/veterinária
[Mh] Termos MeSH secundário: Administração Intravaginal
Animais
Dinoprosta/administração & dosagem
Dinoprosta/farmacologia
Esquema de Medicação
Estradiol/sangue
Feminino
Folículo Ovariano/diagnóstico por imagem
Folículo Ovariano/efeitos dos fármacos
Paridade
Gravidez
Progesterona/administração & dosagem
Progesterona/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
4G7DS2Q64Y (Progesterone); 4TI98Z838E (Estradiol); B7IN85G1HY (Dinoprost)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171201
[Lr] Data última revisão:
171201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:28923283
[Au] Autor:Jansen CHJR; Elisen MGLM; Leenstra CW; Kaaijk EM; van Stralen KJ; Verhoeve HR
[Ad] Endereço:Department of Obstetrics and Gynaecology, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands. Electronic address: chjr.jansen@gmail.com.
[Ti] Título:Longer time interval between semen processing and intrauterine insemination does not affect pregnancy outcome.
[So] Source:Fertil Steril;108(5):764-769, 2017 Nov.
[Is] ISSN:1556-5653
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To study whether the pregnancy outcome of intrauterine insemination (IUI) is affected by a longer time interval between semen processing and insemination. DESIGN: Retrospective cohort. SETTING: Teaching hospital. PATIENT(S): Couples with subfertility and an indication for IUI over a 10-year period. INTERVENTION (S): Insemination performed the day after but within 24 hours of semen collection and processing (delayed insemination) compared with insemination performed immediately after sperm collection and processing (immediate insemination). MAIN OUTCOME MEASURE(S): Ongoing pregnancy rate, defined as a pregnancy confirmed by ultrasound at 10 to 12 weeks of gestation. RESULT(S): In total, 1,136 cycles were analyzed. In 77 of 547 couples (14%) an ongoing pregnancy occurred after delayed insemination, and in 77 of 589 couples (13%) an ongoing pregnancy occurred after immediate insemination. Both groups had similar baseline characteristics. After adjustment for confounders, there was no difference in the ongoing pregnancy rate between delayed as compared with immediate insemination (odds ratio 0.89; 95% confidence interval, 0.63-1.25). CONCLUSION(S): There is no negative effect on pregnancy rate when IUI of processed sperm is delayed until the next day. This approach allows additional flexibility for couples when the male partner is not available on the day of ovulation, and it allows for a spread of workload in the laboratory.
[Mh] Termos MeSH primário: Infertilidade/terapia
Inseminação Artificial/métodos
Manejo de Espécimes/métodos
Tempo para o Tratamento
Doadores de Tecidos
[Mh] Termos MeSH secundário: Adulto
Feminino
Fertilidade
Seres Humanos
Infertilidade/diagnóstico
Infertilidade/fisiopatologia
Inseminação Artificial/efeitos adversos
Modelos Logísticos
Masculino
Análise Multivariada
Razão de Chances
Gravidez
Resultado da Gravidez
Taxa de Gravidez
Estudos Retrospectivos
Fatores de Risco
Análise do Sêmen
Manejo de Espécimes/efeitos adversos
Fatores de Tempo
Resultado do Tratamento
Ultrassonografia Pré-Natal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170920
[St] Status:MEDLINE


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[PMID]:28863171
[Au] Autor:Mech LD; Asa CS; Callahan M; Christensen BW; Smith F; Young JK
[Ad] Endereço:U. S. Geological Survey, Northern Prairie Wildlife Research Center, Jamestown, North Dakota, United States of America.
[Ti] Título:Studies of wolf x coyote hybridization via artificial insemination.
[So] Source:PLoS One;12(9):e0184342, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Following the production of western gray wolf (Canis lupus) x western coyote (Canis latrans) hybrids via artificial insemination (AI), the present article documents that the hybrids survived in captivity for at least 4 years and successfully bred with each other. It further reports that backcrossing one of the hybrids to a male gray wolf by AI also resulted in the birth of live pups that have survived for at least 10 months. All male hybrids (F1 and F2) produced sperm by about 10 months of age, and sperm quality of the F1 males fell within the fertile range for domestic dogs, but sperm motility and morphology, in particular, were low in F2 males at 10 months but improved in samples taken at 22 months of age. These studies are relevant to a long-standing controversy about the identity of the red wolf (Canis rufus), the existence of a proposed new species (Canis lycaon) of gray wolf, and to the role of hybridization in mammalian evolution.
[Mh] Termos MeSH primário: Coiotes/genética
Hibridização Genética
Inseminação Artificial
Lobos/genética
[Mh] Termos MeSH secundário: Animais
Cruzamentos Genéticos
Feminino
Genética Populacional
Geografia
Masculino
América do Norte
Filogenia
Motilidade Espermática
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170902
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184342


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[PMID]:28771718
[Au] Autor:Maher MA; Abdelaziz A; Shehata YA
[Ad] Endereço:Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, Shebin-Elkom, Egypt.
[Ti] Título:Effect of follicular diameter at the time of ovulation triggering on pregnancy outcomes during intrauterine insemination.
[So] Source:Int J Gynaecol Obstet;139(2):174-179, 2017 Nov.
[Is] ISSN:1879-3479
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To compare pregnancy outcomes when triggering ovulation at different follicle sizes during intrauterine insemination (IUI) cycles. METHODS: A prospective observational study was undertaken at two collaborative fertility centers in Saudi Arabia between January 2014 and May 2016. Women of any age were enrolled if they met inclusion criteria: primary, secondary, or unexplained infertility (≥1 year); day-2 follicle-stimulating hormone less than 12 IU/mL; normal prolactin, thyroid function, and uterine cavity; at least one patent tube; and a male partner with normal semen count and motility. IUI cycles were subdivided by size of dominant follicle (17 to <18 mm, 18 to <19 mm, 19 to <20 mm, and ≥20 mm), and pregnancy outcomes compared. RESULTS: Data from 516 IUI cycles were analyzed. Frequencies of clinical pregnancy, ongoing pregnancy, and live birth for a follicle size of 19-20 mm were 30.2% (39/129), 24.0% (31/129), and 24.0% (31/129), respectively; these rates were significantly higher than those in other groups (all P<0.05). Only endometrial thickness was found to also contribute to outcome: probability of pregnancy increased as thickness rose (odds ratio 1.148, 95% confidence interval 1.065-1.237; P<0.001). CONCLUSION: The optimal follicular diameter associated with increased pregnancy rates in gonadotropin-stimulated IUI cycles was between 19 and 20 mm.
[Mh] Termos MeSH primário: Inseminação Artificial
Folículo Ovariano/diagnóstico por imagem
Indução da Ovulação/métodos
[Mh] Termos MeSH secundário: Adulto
Gonadotropina Coriônica/administração & dosagem
Esquema de Medicação
Feminino
Seres Humanos
Masculino
Folículo Ovariano/efeitos dos fármacos
Gravidez
Resultado da Gravidez
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Chorionic Gonadotropin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.1002/ijgo.12291


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[PMID]:28600104
[Au] Autor:Guo Y; Liu W; Wang Y; Pan J; Liang S; Ruan J; Teng X
[Ad] Endereço:Department of Assisted Reproduction, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China; Department of Cellular and Genetic Medicine, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
[Ti] Título:Polarization microscopy imaging for the identification of unfertilized oocytes after short-term insemination.
[So] Source:Fertil Steril;108(1):78-83, 2017 Jul.
[Is] ISSN:1556-5653
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To develop a unique approach using polarization microscopy (PM) to determine whether the presence of a spindle can be used as an indicator associated with fertilization failure 5 hours after short-term insemination. DESIGN: Observational study. SETTING: Assisted reproduction center. PATIENT(S): Eighty-five patients undergoing short-term insemination. INTERVENTION(S): Oocytes imaged via PM at 4, 5, and 6 hours after standard insemination. MAIN OUTCOME MEASURE(S): Spindle visualization and fertilization rate, with rescue intracytoplasmic sperm injection (ICSI) results determined by rates of normal fertilization, abnormal fertilization, and good-quality embryo formation. RESULT(S): After standard insemination, comparisons of spindle visualization at three time points indicated that the predictive accuracy rates were 84.30% at 5 hours, 86.80% at 6 hours, and 62.20% at 4 hours, with the rates at 5 and 6 hours statistically significantly higher than at 4 hours. A spindle was present in 242 of the 788 metaphase-II oocytes 5 hours after insemination, and there were 204 failed fertilizations on day 1. The positive predictive value was 0.84. After rescue ICSI, the abnormal fertilization rate of the polar body group (assessed using the polar body visualization method) was statistically significantly higher than that of the PM group (assessed using the spindle visualization method) and the regular ICSI group (9.37%, 5.88%, and 4.87%, respectively). CONCLUSION(S): The presence of a spindle 5 hours after insemination in in vitro fertilization is an accurate indicator of unfertilized oocytes. Spindle imaging combined with rescue measures effectively prevents fertilization failure and decreases the polyspermy rate.
[Mh] Termos MeSH primário: Infertilidade/patologia
Infertilidade/terapia
Microscopia de Polarização/métodos
Oócitos/patologia
Resultado da Gravidez
Injeções de Esperma Intracitoplásmicas/métodos
[Mh] Termos MeSH secundário: China/epidemiologia
Feminino
Seres Humanos
Infertilidade/epidemiologia
Inseminação Artificial/métodos
Gravidez
Resultado da Gravidez/epidemiologia
Prevalência
Prognóstico
Reprodutibilidade dos Testes
Medição de Risco
Sensibilidade e Especificidade
Resultado do Tratamento
[Pt] Tipo de publicação:CONTROLLED CLINICAL TRIAL; JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170611
[St] Status:MEDLINE


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[PMID]:28520723
[Au] Autor:Saragusty J; Lemma A; Hildebrandt TB; Göritz F
[Ad] Endereço:Department of Reproduction Management, Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany.
[Ti] Título:Follicular size predicts success in artificial insemination with frozen-thawed sperm in donkeys.
[So] Source:PLoS One;12(5):e0175637, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In asses, semen collection, cryopreservation, and artificial insemination (AI) with frozen-thawed semen have been scarcely described and success rate, particularly following AI, is reportedly low. In the absence of reliable protocols, assisted reproductive technologies cannot support the conservation efforts aimed at endangered wild ass species and domestic donkey breeds. Two experiments were conducted in this study. In experiment 1 we evaluated freezing Abyssinian donkey (N = 5, 4 ejaculates each) spermatozoa using three freezing extenders (Berliner Cryomedium + glycerol, BC+G; BotuCrio, BOTU; INRAFreeze, INRA) and two cryopreservation techniques (liquid nitrogen vapour, LNV; directional freezing, DF). Post-thaw evaluation indicated that BOTU and INRA were similar and both superior to BC+G (P ≤ 0.004 for all motility tests), and that DF was superior to LNV (P < 0.002 for all evaluation parameters). In experiment 2, relying on these results, we used Abyssinian donkey sperm frozen in BOTU and INRA by DF for AI (N = 20). Prior to AI, thawed samples were diluted in corresponding centrifugation media or autologous seminal fluids at 1:1 ratio. No difference was found between BOTU and INRA or between the addition of seminal fluids or media, all resulting in ~50% pregnancy, and no differences were noted between males (N = 4). The size of pre-ovulatory follicle was a significant (P = 0.001) predictor for AI success with 9/10 pregnancies occurring when follicular size ranged between 33.1-37.4 mm, no pregnancy when it was smaller, and only one when larger. A number of ass species face the risk of extinction. Knowledge gained in this study on the Abyssinian donkey can be customised and transferred to its closely related endangered species and breeds.
[Mh] Termos MeSH primário: Criopreservação/métodos
Inseminação Artificial/veterinária
Folículo Ovariano/citologia
Preservação do Sêmen/métodos
[Mh] Termos MeSH secundário: Animais
Criopreservação/veterinária
Equidae/fisiologia
Feminino
Inseminação Artificial/métodos
Masculino
Folículo Ovariano/fisiologia
Preservação do Sêmen/efeitos adversos
Preservação do Sêmen/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170519
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0175637


  9 / 8720 MEDLINE  
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[PMID]:28501361
[Au] Autor:Nandi A; Bhide P; Hooper R; Gudi A; Shah A; Khan K; Homburg R
[Ad] Endereço:Fertility Unit, Homerton University Hospital, London, United Kingdom. Electronic address: anupa.nandi@gmail.com.
[Ti] Título:Intrauterine insemination with gonadotropin stimulation or in vitro fertilization for the treatment of unexplained subfertility: a randomized controlled trial.
[So] Source:Fertil Steril;107(6):1329-1335.e2, 2017 Jun.
[Is] ISSN:1556-5653
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate the best first line management option for the treatment of unexplained subfertility-controlled ovarian hyperstimulation (COH) with gonadotropins and IUI or IVF. DESIGN: Randomized controlled trial. SETTING: Single center trial in a tertiary referral unit. PATIENT(S): Couples with unexplained subfertility. INTERVENTION(S): Couples were randomized to receive either three cycles of IUI + COH or one cycle of IVF. MAIN OUTCOME MEASURE(S): Singleton pregnancy rate (PR) per couple. RESULT(S): A total of 207 couples were randomly assigned to three cycles of IUI + COH (n = 101) or one cycle of IVF (n = 106). There were 25 (24.7%) singleton live births for the IUI + COH group and 33 (31.1%) for the IVF group (relative risk, 1.3; 95% confidence interval [CI] 0.81-1.96) with an absolute risk difference of 6.4% (95% CI -5.8% to 18.6%). The multiple pregnancies per live birth were 4 (13.8%) for the IUI + COH group and 3 (8.3%) for the IVF group (relative risk, 0.6; 95% CI 0.14-2.4). There were no cases of ovarian hyperstimulation syndrome (OHSS) in the IUI group and three cases of OHSS (3.7%) in the IVF group. There were 17 live births from spontaneous conception in between treatment cycles (8.2%). CONCLUSION(S): The singleton live birth rate with one cycle of IVF was not significantly different than three cycles of IUI + COH. CLINICAL TRIAL REGISTRATION NUMBER: ISRCTN43430382.
[Mh] Termos MeSH primário: Fertilização In Vitro/utilização
Gonadotropinas/administração & dosagem
Infertilidade/terapia
Inseminação Artificial/utilização
Indução da Ovulação/utilização
Taxa de Gravidez
[Mh] Termos MeSH secundário: Adulto
Terapia Combinada/métodos
Terapia Combinada/utilização
Comorbidade
Feminino
Seres Humanos
Infertilidade/diagnóstico
Masculino
Síndrome de Hiperestimulação Ovariana/epidemiologia
Síndrome de Hiperestimulação Ovariana/prevenção & controle
Gravidez
Resultado da Gravidez/epidemiologia
Fatores de Risco
Resultado do Tratamento
Reino Unido/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Gonadotropins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170515
[St] Status:MEDLINE


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[PMID]:28499352
[Au] Autor:Wang Y; Bennewitz J; Wellmann R
[Ad] Endereço:Institute of Animal Science, University of Hohenheim, 70593, Stuttgart, Germany. yu.wang@uni-hohenheim.de.
[Ti] Título:Novel optimum contribution selection methods accounting for conflicting objectives in breeding programs for livestock breeds with historical migration.
[So] Source:Genet Sel Evol;49(1):45, 2017 May 12.
[Is] ISSN:1297-9686
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Optimum contribution selection (OCS) is effective for increasing genetic gain, controlling the rate of inbreeding and enables maintenance of genetic diversity. However, this diversity may be caused by high migrant contributions (MC) in the population due to introgression of genetic material from other breeds, which can threaten the conservation of small local populations. Therefore, breeding objectives should not only focus on increasing genetic gains but also on maintaining genetic originality and diversity of native alleles. This study aimed at investigating whether OCS was improved by including MC and modified kinships that account for breed origin of alleles. Three objective functions were considered for minimizing kinship, minimizing MC and maximizing genetic gain in the offspring generation, and we investigated their effects on German Angler and Vorderwald cattle. RESULTS: In most scenarios, the results were similar for Angler and Vorderwald cattle. A significant positive correlation between MC and estimated breeding values of the selection candidates was observed for both breeds, thus traditional OCS would increase MC. Optimization was performed under the condition that the rate of inbreeding did not exceed 1% and at least 30% of the maximum progress was achieved for all other criteria. Although traditional OCS provided the highest breeding values under restriction of classical kinship, the magnitude of MC in the progeny generation was not controlled. When MC were constrained or minimized, the kinship at native alleles increased compared to the reference scenario. Thus, in addition to constraining MC, constraining kinship at native alleles is required to ensure that native genetic diversity is maintained. When kinship at native alleles was constrained, the classical kinship was automatically lowered in most cases and more sires were selected. However, the average breeding value in the next generation was also lower than that obtained with traditional OCS. CONCLUSIONS: For local breeds with historical introgressions, current breeding programs should focus on increasing genetic gain and controlling inbreeding, as well as maintaining the genetic originality of the breeds and the diversity of native alleles via the inclusion of MC and kinship at native alleles in the OCS process.
[Mh] Termos MeSH primário: Bovinos/genética
Seleção Artificial
[Mh] Termos MeSH secundário: Animais
Feminino
Aptidão Genética
Endogamia
Inseminação Artificial/veterinária
Masculino
Polimorfismo Genético
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170514
[St] Status:MEDLINE
[do] DOI:10.1186/s12711-017-0320-7



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