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[PMID]:26311000
[Au] Autor:Shahrokh Tehraninejad E; Azimi Nekoo E; Ghaffari F; Hafezi M; Karimian L; Arabipoor A
[Ad] Endereço:Departments of Endocrinology and Female Infertility.
[Ti] Título:Zygote intrafallopian tube transfer versus intrauterine cleavage or blastocyst stage transfer after intracytoplasmic sperm injection cycles in patients with repeated implantation failure: A prospective follow-up study.
[So] Source:J Obstet Gynaecol Res;41(11):1779-84, 2015 Nov.
[Is] ISSN:1447-0756
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:AIM: This study aimed to compare the outcomes between zygote intrafallopian transfer (ZIFT) with intrauterine day-3 (cleavage stage) embryo transfer and intrauterine day-5 (blastocyst stage) embryo transfer in patients undergoing intracytoplasmic sperm injection. MATERIAL AND METHODS: This prospective study was performed at Royan Institute, Tehran, Iran, between January 2012 and January 2014. Two hundred fifty women with more than three unexplained implantation failures were divided non-randomly into three groups according to embryonic age and methods used as follows: (i) intrauterine cleavage-stage embryo transfer (n = 100); (ii) intrauterine blastocyst-stage embryo transfer (n = 50); and (iii) ZIFT (n = 100). Implantation, clinical pregnancy, miscarriage and live birth rates were our main outcomes. RESULTS: Patients' characteristics and ovarian response were comparable among the three groups. Implantation rate (56.1% vs 27.9%) was significantly higher in the blastocyst group as compared to the ZIFT group; however, clinical pregnancy rate (38% vs 23%) was not statistically significantly different between the two groups, but due to the significantly higher miscarriage rate (34.7% vs 5.3%) in the ZIFT group, the live birth rate was significantly higher in the blastocyst group (P = 0.04). No significant differences were found between the cleavage-stage and blastocyst-stage groups in terms of implantation, clinical pregnancy, miscarriage and live birth rates. CONCLUSION: We do not recommend the use of the ZIFT procedure for patients with repeated implantation failures. It seems that replication of cleavage- or blastocyst-stage embryo transfer is more efficient and affordable.
[Mh] Termos MeSH primário: Transferência Embrionária
Injeções de Esperma Intracitoplásmicas
Transferência Intratubária do Zigoto
[Mh] Termos MeSH secundário: Aborto Espontâneo
Adulto
Feminino
Seguimentos
Seres Humanos
Gravidez
Resultado da Gravidez
Taxa de Gravidez
Estudos Prospectivos
Falha de Tratamento
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150828
[St] Status:MEDLINE
[do] DOI:10.1111/jog.12779


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[PMID]:26051461
[Au] Autor:Liu Y; Chapple V; Feenan K; Roberts P; Matson P
[Ad] Endereço:Fertility North, Joondalup Private Hospital, Joondalup, Western Australia, Australia; School of Medical Sciences, Edith Cowan University, Joondalup, Western Australia, Australia. Electronic address: yanhe.liu@fertilitynorth.com.au.
[Ti] Título:Time-lapse videography of human embryos: Using pronuclear fading rather than insemination in IVF and ICSI cycles removes inconsistencies in time to reach early cleavage milestones.
[So] Source:Reprod Biol;15(2):122-5, 2015 Jun.
[Is] ISSN:2300-732X
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Time-lapse videography showed that human early cleavage embryos were quicker following intracytoplasmic sperm injection to reach developmental milestones compared to in vitro fertilization when using insemination as the timing start point (t0), due to differences in the time taken for embryos to reach pronuclear fading (PNF). These differences disappeared when PNF was used as t0. Using a biological rather than procedural t0 will allow a unified assessment strategy to be applied to all cycles irrespective of the insemination method.
[Mh] Termos MeSH primário: Fase de Clivagem do Zigoto/citologia
Desenvolvimento Embrionário
Transferência Intratubária do Zigoto
[Mh] Termos MeSH secundário: Fase de Clivagem do Zigoto/transplante
Estudos de Coortes
Ectogênese
Transferência Embrionária
Embrião de Mamíferos/citologia
Feminino
Fertilização In Vitro
Seres Humanos
Cinética
Gravidez
Estudos Retrospectivos
Injeções de Esperma Intracitoplásmicas
Imagem com Lapso de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150608
[Lr] Data última revisão:
150608
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150609
[St] Status:MEDLINE


  3 / 158 MEDLINE  
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[PMID]:25599823
[Au] Autor:Ménézo Y; Guérin P; Elder K
[Ad] Endereço:Laboratoire CLEMENT, 17 Avenue d'Eylau, 75016 Paris, France. Electronic address: yves.menezo@gmail.com.
[Ti] Título:The oviduct: a neglected organ due for re-assessment in IVF.
[So] Source:Reprod Biomed Online;30(3):233-40, 2015 Mar.
[Is] ISSN:1472-6491
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The oviduct has long been considered a 'pipeline', a tube allowing transit of spermatozoa and embryos; this perspective has been reinforced by the success of human IVF. Evidence accumulated over several decades, however, indicates that embryos can modulate the metabolism of tubal cells in their environment. Human IVF culture media is based on formulations that pass mouse embryo assays as quality control: the requirements of mouse embryos differ from those of human embryos, and therefore conditions for human IVF are far removed from the natural environment of the oviduct. The preimplantation environment, both in vitro and in vivo, is known to affect the health of offspring through mechanisms that influence imprinting. Recent studies also show that male accessory glands act in synergy with the oviduct in providing an optimal environment, and this represents a further perspective on the oviduct's contribution to harmonious embryo development and subsequent long-term health. The metabolism of the human embryo is far from being understood, and a 'return' to in-vivo conditions for preimplantation development is worthy of consideration. Although results obtained in rodents must be interpreted with caution, lessons learned from animal embryo culture must not be neglected.
[Mh] Termos MeSH primário: Ectogênese
Técnicas de Cultura Embrionária/métodos
Transferência Embrionária/efeitos adversos
Tubas Uterinas/fisiologia
Infertilidade Feminina/terapia
Modelos Biológicos
Sêmen/fisiologia
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Técnicas de Cocultura
Desenvolvimento Embrionário
Tubas Uterinas/citologia
Tubas Uterinas/fisiopatologia
Tubas Uterinas/secreção
Feminino
Fertilização In Vitro/efeitos adversos
Transferência Intrafalopiana de Gameta/efeitos adversos
Seres Humanos
Infertilidade Feminina/metabolismo
Infertilidade Feminina/fisiopatologia
Masculino
Gravidez
Transferência Intratubária do Zigoto/efeitos adversos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1512
[Cu] Atualização por classe:150305
[Lr] Data última revisão:
150305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150121
[St] Status:MEDLINE


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[PMID]:25187232
[Au] Autor:Hisamatsu S; Sakaue M; Takizawa A; Kato T; Kamoshita M; Ito J; Kashiwazaki N
[Ad] Endereço:Department of Environmental Sciences, School of Life and Environmental Science, Azabu University, Sagamihara, Japan.
[Ti] Título:Knockout of targeted gene in porcine somatic cells using zinc-finger nuclease.
[So] Source:Anim Sci J;86(2):132-7, 2015 Feb.
[Is] ISSN:1740-0929
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Targeted genome editing is a widely applicable approach for efficiently modifying any sequence of interest in animals. It is very difficult to generate knock-out and knock-in animals except for mice up to now. Very recently, a method of genome editing using zinc-finger nucleases (ZFNs) has been developed to produce knockout rats. Since only injection of ZFNs into the pronuclear (PN) embryo is required, it seems to be useful for generating gene-targeted animals, including domestic species. However, no one has reported the successful production of knockout pigs by direct injection of ZFNs into PN embryos. We examined whether ZFN works on editing the genome of porcine growth hormone receptor in two kinds of cell lines (ST and PT-K75) derived from the pig as a preliminary study. Our data showed that pZFN1/2 vectors were efficiently transfected into both ST and PT-K75 cells. In both cell lines, results from Cel-I assay showed that modification of the targeted gene was confirmed. We injected ZFN1/2 mRNAs into the nucleus of PN stage embryos and then they were transferred to the recipients. However, pups were not delivered. Taken together, ZFN can be an available technology of genome editing even in the pig but further improvement will be required for generating genome-modified pigs.
[Mh] Termos MeSH primário: Endonucleases/administração & dosagem
Técnicas de Inativação de Genes/métodos
Marcação de Genes/métodos
Genoma/genética
Receptores da Somatotropina/genética
Suínos/embriologia
Suínos/genética
Dedos de Zinco
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Núcleo Celular
Endonucleases/química
Endonucleases/genética
Feminino
Vetores Genéticos
Camundongos
Microinjeções/métodos
Ratos
Transfecção
Transferência Intratubária do Zigoto
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Receptors, Somatotropin); EC 3.1.- (Endonucleases)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:150129
[Lr] Data última revisão:
150129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140905
[St] Status:MEDLINE
[do] DOI:10.1111/asj.12259


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[PMID]:25187950
[Au] Autor:Chou CJ; Peng SY; Wu MH; Yang CC; Lin YS; Cheng WT; Wu SC; Lin YP
[Ad] Endereço:Institute of Biotechnology, National Taiwan University, Taipei, Taiwan.
[Ti] Título:Generation and characterization of a transgenic pig carrying a DsRed-monomer reporter gene.
[So] Source:PLoS One;9(9):e106864, 2014.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Pigs are an optimal animal for conducting biomedical research because of their anatomical and physiological resemblance to humans. In contrast to the abundant resources available in the study of mice, few fluorescent protein-harboring porcine models are available for preclinical studies. In this paper, we report the successful generation and characterization of a transgenic DsRed-Monomer porcine model. METHODS: The transgene comprised a CMV enhancer/chicken-beta actin promoter and DsRed monomeric cDNA. Transgenic pigs were produced by using pronuclear microinjection. PCR and Southern blot analyses were applied for identification of the transgene. Histology, blood examinations and computed tomography were performed to study the health conditions. The pig amniotic fluid progenitor/stem cells were also isolated to examine the existence of red fluorescence and differentiation ability. RESULTS: Transgenic pigs were successfully generated and transmitted to offspring at a germ-line transmission rate of 43.59% (17/39). Ubiquitous expression of red fluorescence was detected in the brain, eye, tongue, heart, lung, liver, pancreas, spleen, stomach, small intestine, large intestine, kidney, testis, and muscle; this was confirmed by histology and western blot analyses. In addition, we confirmed the differentiation potential of amniotic fluid progenitor stem cells isolated from the transgenic pig. CONCLUSIONS: This red fluorescent pig can serve as a host for other fluorescent-labeled cells in order to study cell-microenvironment interactions, and can provide optimal red-fluorescent-labeled cells and tissues for research in developmental biology, regenerative medicine, and xenotransplantation.
[Mh] Termos MeSH primário: Animais Geneticamente Modificados
Efeito Fundador
Proteínas Luminescentes/genética
Suínos/genética
Transferência Intratubária do Zigoto/veterinária
[Mh] Termos MeSH secundário: Actinas/genética
Actinas/metabolismo
Líquido Amniótico/citologia
Animais
Diferenciação Celular
Células Cultivadas
Galinhas
Citomegalovirus/química
Citomegalovirus/genética
DNA Complementar/administração & dosagem
Elementos Facilitadores Genéticos
Feminino
Fluorescência
Expressão Gênica
Genes Reporter
Proteínas Luminescentes/metabolismo
Masculino
Microinjeções
Regiões Promotoras Genéticas
Células-Tronco/citologia
Células-Tronco/fisiologia
Suínos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Actins); 0 (DNA, Complementary); 0 (Luminescent Proteins); 0 (fluorescent protein 583)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140905
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0106864


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[PMID]:24966120
[Au] Autor:Nakagawa K; Juen H; Nishi Y; Sugiyama R; Motoyama H; Kuribayashi Y; Inoue M; Akira S; Sugiyama R
[Ad] Endereço:Division of Reproductive Medicine, Sugiyama Clinic, 1-53-1, Ohara, Setagaya-ku, Tokyo, 156-0041, Japan, koji@sugiyama.or.jp.
[Ti] Título:Advanced scheduling for zygote intrafallopian transfer is possible via the use of a hormone replacement cycle for patients who have experienced repeated implantation failures.
[So] Source:Arch Gynecol Obstet;290(5):1031-5, 2014 Nov.
[Is] ISSN:1432-0711
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Zygote intrafallopian transfer (ZIFT) is an effective option for patients who have experienced repeated implantation failures (RIF) in assisted reproductive technology (ART) treatment. However, advance planning for the day of the operation can be problematic. Using a hormone replacement cycle (HRC) makes it possible to plan for the day of ZIFT. In the present study, we evaluated whether HRC-ZIFT is useful for RIF patients who have experienced difficulties obtaining morphologically good embryos in vitro. METHODS: A total of 55 patients with a history of five or more unsuccessful transfers received HRC-ZIFT between June 2008 and June 2013. The oocyte pick-ups were performed and the oocytes showing two pronuclei (2PN) were cryopreserved. After receiving more than five 2PN oocytes, the operation day was scheduled in advance, and as a consequence, a HRC was started and ZIFT was performed. The clinical outcomes were evaluated. RESULTS: The average age of the patients was 39.3 years, and the previous OPU and ET attempts numbered 7.5 and 6.9, respectively. The number of previously transferred embryos was 11.8, and the number of morphologically good embryos (MGEs) was only 1.2. The number of transferred 2PN oocytes was 6.7, and the subsequent pregnancy rate was 23.6 %. No ectopic or multiple pregnancies were observed, but there were 6 cases of miscarriage. CONCLUSION: Among RIF patients, in particular those who have difficulty obtaining MGEs in vitro, ZIFT might be a useful option. The HRC allows patients and medical staff to plan for the operation day in advance.
[Mh] Termos MeSH primário: Implantação do Embrião
Transferência Embrionária/métodos
Terapia de Reposição Hormonal/métodos
Infertilidade Feminina/terapia
Transferência Intratubária do Zigoto/métodos
[Mh] Termos MeSH secundário: Adulto
Criopreservação
Feminino
Seres Humanos
Gravidez
Taxa de Gravidez
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1502
[Cu] Atualização por classe:141006
[Lr] Data última revisão:
141006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140627
[St] Status:MEDLINE
[do] DOI:10.1007/s00404-014-3324-3


  7 / 158 MEDLINE  
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[PMID]:24581992
[Au] Autor:Stecher A; Vanderzwalmen P; Zintz M; Wirleitner B; Schuff M; Spitzer D; Zech NH
[Ad] Endereço:IVF Centers Prof. Zech-Bregenz, Austria. Electronic address: a.stecher@ivf.at.
[Ti] Título:Transfer of blastocysts with deviant morphological and morphokinetic parameters at early stages of in-vitro development: a case series.
[So] Source:Reprod Biomed Online;28(4):424-35, 2014 Apr.
[Is] ISSN:1472-6491
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Time-lapse imaging is increasingly applied as an adjunct to reproductive medicine. The gained information of the morphological and morphokinetic variables before the onset of transcription are supposed to be good predictors for the selection of the best embryo for transfer and are often seen in line with clinical outcomes. This retrospective case series investigated the outcome of transferred blastocysts that did not fulfil the proposed embryo scores at early cleavage or at later stages of development. The observations were made by time-lapse imaging. This study reports the birth of 16 healthy children after day-5 blastocyst transfer, of which at least one of the transferred embryos originated from deviant morphology and/or kinetic cleavage patterns. This case series suggests that some blastocysts derived from embryos with poor conventional morphological score and/or suboptimal morphokinetics can be successfully transferred and might result in live births. Such results might raise awareness that discarding embryos based only on early events is not a suitable approach to give patients the chance to conceive. In conclusion, to date only the transfer of viable embryos after culturing them until day 5 guarantees optimal embryo selection and helps to prevent embryo wastage.
[Mh] Termos MeSH primário: Blastocisto
Transferência Embrionária
Oócitos
[Mh] Termos MeSH secundário: Adulto
Técnicas de Cultura Embrionária
Implantação do Embrião
Retículo Endoplasmático Liso
Feminino
Seres Humanos
Masculino
Oócitos/citologia
Gravidez
Estudos Retrospectivos
Imagem com Lapso de Tempo
Transferência Intratubária do Zigoto
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1411
[Cu] Atualização por classe:140407
[Lr] Data última revisão:
140407
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140304
[St] Status:MEDLINE


  8 / 158 MEDLINE  
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[PMID]:24581983
[Au] Autor:Wissing ML; Bjerge MR; Olesen AI; Hoest T; Mikkelsen AL
[Ad] Endereço:Holbaek Fertility Clinic, Smedelundsgade 60, 4300 Holbaek, Denmark. Electronic address: mlwi@regionsjaelland.dk.
[Ti] Título:Impact of PCOS on early embryo cleavage kinetics.
[So] Source:Reprod Biomed Online;28(4):508-14, 2014 Apr.
[Is] ISSN:1472-6491
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This study investigated whether polycystic ovary syndrome (PCOS) affected early embryo development assessed by time-lapse analysis of embryo kinetics from fertilization to the blastocyst stage. This was a prospective cohort study of two pronuclei (2PN) embryos from 25 hyperandrogenic PCOS patients (110 2PN embryos), 26 normoandrogenic PCOS patients (140 2PN embryos) and 20 healthy, regularly cycling women (controls, 97 2PN embryos). Patients underwent the same baseline evaluation and the same ovarian stimulation from April 2010 to February 2013. Oocytes were fertilized by intracytoplasmic sperm injection and incubated in an EmbryoScope with pictures taken every 20 min in seven focal planes. Time to 2PN breakdown, first cleavage and cleavage to 3, 4, 5, 6, 7 and 8 cells, morula and blastocyst (t2, t3, t4, t5, t6, t7, t8, t(M), t(B)) were annotated. Differences in embryo kinetics between groups were assessed by mixed modelling. Compared with controls, embryos from hyperandrogenic PCOS patients were significantly delayed at 2PN breakdown, t2, t3, t4 and t7 but not at t5, t6, t8, t(M) or t(B). Embryos from hyperandrogenic PCOS women had developed slower from fertilization to the 8-cell stage compared with embryos from controls.
[Mh] Termos MeSH primário: Desenvolvimento Embrionário
Síndrome do Ovário Policístico/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Hiperandrogenismo/fisiopatologia
Gravidez
Estudos Prospectivos
Injeções de Esperma Intracitoplásmicas
Imagem com Lapso de Tempo
Transferência Intratubária do Zigoto
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1411
[Cu] Atualização por classe:140407
[Lr] Data última revisão:
140407
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140304
[St] Status:MEDLINE


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[PMID]:24444039
[Au] Autor:Gat I; Levron J; Yerushalmi G; Dor J; Brengauz M; Orvieto R
[Ti] Título:Should zygote intrafallopian transfer be offered to all patients with unexplained repeated in-vitro fertilization cycle failures?
[So] Source:J Ovarian Res;7:7, 2014 Jan 20.
[Is] ISSN:1757-2215
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: One of the suggest strategy for patients with repeated implantation failure (RIF) is zygote intrafallopian transfer (ZIFT). However, no data exist regarding to the issue of when and under which circumstances should ZIFT be offered to patients with RIF? We therefore aimed to examine whether repeated implantation failure (RIF) patients characteristics or their previous controlled ovarian hyperstimulation (COH) variables may differentiate between those who will conceive following a ZIFT cycle and those who will not. METHODS: Forty seven consecutive women admitted to our IVF unit during a 7 year period, who underwent ZIFT for RIF, were included. Ovarian stimulation characteristics, number of oocytes retrieved and number and quality of zygotes/embryos transferred were assessed and compared between the ZIFT cycle and the previous IVF/ICSI cycle and between those who conceived following the ZIFT cycle and those who did not. RESULTS: Twelve clinical pregnancies (clinical pregnancy rate- 25.5%) were recorded following the ZIFT cycle. Those who benefit from ZIFT were young patients (≤31 yrs), who underwent ≤6 cycle attempts, yielding over eight 2PN embryos with low (≤0.4) ratio of number of top-quality embryos to total 2PN embryos. Moreover, in those destined for a ZIFT cycle, only those with >7 2PN embryo should undergo a transfer of at least five 2PN embryos. CONCLUSIONS: Further large prospective studies are needed to identify the specific characteristics of RIF women who may benefit from ZIFT.
[Mh] Termos MeSH primário: Fertilização In Vitro
Infertilidade/terapia
Transferência Intratubária do Zigoto
[Mh] Termos MeSH secundário: Adulto
Implantação do Embrião
Transferência Embrionária
Feminino
Fertilidade
Seres Humanos
Infertilidade/diagnóstico
Infertilidade/fisiopatologia
Recuperação de Oócitos
Indução da Ovulação
Seleção de Pacientes
Gravidez
Taxa de Gravidez
Falha de Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1510
[Cu] Atualização por classe:140212
[Lr] Data última revisão:
140212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140122
[St] Status:MEDLINE
[do] DOI:10.1186/1757-2215-7-7


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[PMID]:24390678
[Au] Autor:Berger DS; Zapantis A; Merhi Z; Younger J; Polotsky AJ; Jindal SK
[Ad] Endereço:Montefiore's Institute for Reproductive Medicine and Health, 141 South Central Ave, Suite 201, Hartsdale, NY, 10530, USA.
[Ti] Título:Embryo quality but not pronuclear score is associated with clinical pregnancy following IVF.
[So] Source:J Assist Reprod Genet;31(3):279-83, 2014 Mar.
[Is] ISSN:1573-7330
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The association between pronuclear (PN) scoring of embryos from assisted reproductive technology (ART) and clinical pregnancy remains controversial. We hypothesized that embryos with PNs scored on the day of fertilization check offer better embryo selection on day 3 and higher CPR compared to non-PN scored embryos. METHODS: Patients (19-46 years) undergoing IVF/ICSI cycles at Montefiore's Institute for Reproductive Medicine and Health between January 2006 and December 2009 were included in our study. We analyzed fresh day 3 cycles only with autologous oocytes and partner's fresh sperm (n = 344). A total of 1,899 embryos were included. We compared CPR from non-PN scored embryos (Group 1, n = 835) with PN scored embryos (Group 2, n = 1,064). Composite scores by patient were developed based on embryo disposition. We also assessed traditional embryo grading derived from cell number, fragmentation and cell symmetry. Data analysis included chi square and t test to determine if PN scoring was associated with improved CPR, and to compare the additional variables. RESULTS: CPR between Group 1 and Group 2 were not different (p = 0.91). CPR was significantly associated with female age, number of mature oocytes retrieved, number of day 3 embryos and grade of embryos transferred on day 3 (p < 0.05). CONCLUSION: PN scoring was not associated with improved CPR in day 3 embryo transfers. Mean grade of transferred embryos continues to be a well-established, independent predictor of CPR. We conclude that further refinement of embryo grading by PN scoring is not beneficial.
[Mh] Termos MeSH primário: Implantação do Embrião
Transferência Embrionária
Fertilização In Vitro
Injeções de Esperma Intracitoplásmicas
[Mh] Termos MeSH secundário: Adulto
Fase de Clivagem do Zigoto
Destinação do Embrião
Feminino
Seres Humanos
Masculino
Meia-Idade
Gravidez
Técnicas de Reprodução Assistida
Transferência Intratubária do Zigoto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1410
[Cu] Atualização por classe:150515
[Lr] Data última revisão:
150515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140107
[St] Status:MEDLINE
[do] DOI:10.1007/s10815-013-0162-3



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